RSC - Chem. Soc. Rev. latest articles

Recent advances in cell-surface glycan engineering and its biological applications

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00007F, Review Article

Chang-Hee Lee, Joo Hee Choi, Eunseo Lee, Na Ryeong Kim, Ji Young Hyun, Hak Joong Kim, Injae Shin
We highlight recent advances in cell-surface glycan engineering and its applications for studying glycan-mediated biological events and developing therapeutics.
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Triad of electrocatalytic strategies for polymer monomer synthesis

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00501B, Review Article

AJing Song, Yuanyuan Ma, Ziyang Wu, Min Kuang, Yuqin Zou, Jianping Yang
Electrocatalysis provides a sustainable route for polymer monomer synthesis from renewable feedstocks, and this review summarizes three representative strategies together with system-level considerations for scalable implementation.
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AI for battery-accelerated discovery of high-voltage electrolytes for advanced lithium batteries

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D4CS01250J, Review Article

Yu Zhan, Nan Chen, Li Li, Feng Wu, Renjie Chen
This review provides a comprehensive overview of the recent advances in the artificial intelligence–assisted design of high-voltage electrolytes, introduces the AI4B paradigm, and outlines the key directions for future research.
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Clinical translation and landscape of stimuli-responsive nanomedicines and microscale therapeutics

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00165C, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dmytro Kobzev, Olesia Kulyk, Roman A. Barmin, Anatoliy Tatarets, Roger M. Pallares, Fabian Kiessling, Twan Lammers, Quim Peña
We present a large-scale scientometric (pre-)clinical landscape analysis of stimuli-responsive therapeutics, highlighting the impact of nano-/micro-scale material platforms, and mapping translational barriers and strategies to overcome them.
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Photografting: a method for surface modification

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00331A, Review Article

Jean Pinson
Photografting enables the covalent modification of a wide variety of surfaces—including polymers, metals, carbons, and oxides—through irradiation of a deposited solution.
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SORS and SESORS: deep Raman spectroscopy in biomedical analysis and disease diagnosis

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00071A, Review Article

Open Access

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Priyanka Dey, Nick Stone, Pavel Matousek
Spatially offset Raman spectroscopy (SORS) and its surface-enhanced variant, SESORS, have emerged as transformative techniques in analytical chemistry and biomedical diagnostics, enabling non-invasive, depth-resolved molecular sensing.
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Direct deaminative functionalization

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01298H, Tutorial Review

Zhangkai Cui, Hongjian Lu
This review presents a unified, bond-centric framework for direct deaminative functionalization, redefining amines as versatile handles for step-economic C–C and C–heteroatom bond construction.
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Indium-based colloidal quantum dots for photocatalytic applications: advances and perspectives

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00515B, Review Article

Yixiao Huang, Jianguo Tang, Zhengquan Li, Dongling Ma, Jin Wang, Zhonglin Du
Eco-friendly indium-based quantum dots (InQDs) provide a new direction for designing novel sustainable heavy-metal-free photocatalysts.
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Correction: From solar cells to memristors: halide perovskites as a platform for neuromorphic electronics

Chem. Soc. Rev., 2026, 55,6008-6008
DOI: 10.1039/D6CS90041K, Correction

Open Access

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Natalia Yantara, Xuechao Xing, Divyam Sharma, Darrell Jun Jie Tay, Shibi Varku, Nripan Mathews
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Correction: Chromium-activated phosphors: from theory to applications

Chem. Soc. Rev., 2026, 55,6004-6007
DOI: 10.1039/D6CS90040B, Correction

Open Access

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Shengqiang Liu, Leipeng Li, Bing Chen, Quanlin Liu, Feng Wang
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Precision graphene nanoribbons: chemical strategies for tailored edge, backbone, and electronic structure

Chem. Soc. Rev., 2026, 55,5590-5641
DOI: 10.1039/D6CS00220J, Tutorial Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xinyu Chen, Yuanhuan Qiu, Jin-Jiang Zhang, Xiangyang Liu, Ji Ma, Xu Wang, Xinliang Feng
Recent advances in bottom-up synthesis strategies have enabled precise control over the edge, backbone, and heterostructure of graphene nanoribbons.
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Organic afterglow probes: mechanisms, chemical design, performance optimization, and biomedical applications

Chem. Soc. Rev., 2026, 55,5949-6003
DOI: 10.1039/D4CS00445K, Review Article

Fengrui Yang, Zhe Li, Lingling Lei, Ying Zhou, Xiaobing Zhang, Guosheng Song
This Review systematically summarizes organic activatable afterglow probes, covering their material categories, luminescence mechanisms, responsive design strategies, performance optimization approaches, and representative biological applications.
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Hollow micro-/nanostructures for enhanced pathogen theranostics

Chem. Soc. Rev., 2026, 55,5908-5948
DOI: 10.1039/D5CS00509D, Review Article

Liang Zhang, Yuechun Li, Yuanyuan Zhao, Sheng Chen, Jing Ke, Iman Zarei, Hao Song, Chengzhong Yu, Lizhi Liu
Hollow micro-/nanostructures enable bacterial biosensing and antibacterial therapy, addressing scalability and clinical translation for post-antibiotic era.
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Recent advances in atomically precise metal nanoclusters for photothermal conversion

Chem. Soc. Rev., 2026, 55,5867-5907
DOI: 10.1039/D5CS01312G, Review Article

Wei-Yang Li, Rakesh Kumar Gupta, Kun Zhou, Yan-Feng Bi, Sukhendu Mandal, Di Sun
Summary of design strategies and synthesis methods of atomically precise metal nanoclusters for photothermal conversion, exemplified by various representative systems.
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The condensation of π-conjugated units: a new paradigm for designing high-performance optical crystals

Chem. Soc. Rev., 2026, 55,5838-5866
DOI: 10.1039/D5CS01327E, Review Article

Hangwei Jia, Bailin Chen, Fangfang Zhang, Xueling Hou, Shilie Pan
π-CUCP provides a new direction for designing novel high-performance optical crystals.
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Synthetic receptors for steroids: from molecular recognition to biomedical functions

Chem. Soc. Rev., 2026, 55,5813-5837
DOI: 10.1039/D5CS01092F, Review Article

Yue Liu, Qing-Yu Zhao, Si-Dan Guo, Kang Cai
Synthetic receptors for steroids have progressed from fundamental molecular recognition to diverse biomedical applications. This review summarizes recent advances and highlights their roles in sensing, imaging, and therapeutic contexts.
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Catalytic strain-release enabled cycloaddition of carbonyl activated bicyclo[1.1.0]butanes

Chem. Soc. Rev., 2026, 55,5776-5812
DOI: 10.1039/D5CS01224D, Review Article

Binghui Wang, Xu Ban, Zhiyong Jiang
Bicyclo[1.1.0]butanes (BCBs), characterized by their compact and highly strained carbocyclic frameworks, have emerged as versatile building blocks in modern synthetic chemistry.
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Intelligent optoelectronics and electronics based on electrospinning technology

Chem. Soc. Rev., 2026, 55,5669-5706
DOI: 10.1039/D5CS01179E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shuwen Xin, You Meng, Li Ni, Aolin Wang, Jinwei Pu, Siyuan Wu, Xin Peng, Yujin Liu, Kun Tang, Zhengxun Lai, He Shao, Johnny C. Ho
Electrospinning offers precise control of nanofiber architectures for multifunctional intelligent (opto)electronic devices. This review highlights structure–property–application relationships in smart sensing, energy, and neuromorphic systems.
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Covalent organic framework membranes for ion separation and ion-driven energy conversion

Chem. Soc. Rev., 2026, 55,5728-5775
DOI: 10.1039/D5CS01237F, Review Article

Qing Guo, Jiaming Yi, Huixia Lv, Zhuozhi Lai, Qi Sun
This review summarizes recent advances in COF membranes for ion separation and their applications in resource recovery, wastewater treatment, and iontronic energy devices. Benchmarking reveals clear structure–property–performance relationships.
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Thermodynamics of metal–organic frameworks: from fundamentals to advanced applications

Chem. Soc. Rev., 2026, 55,5707-5727
DOI: 10.1039/D6CS00060F, Review Article

Open Access

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Grace C. Thaggard, Danielle N. Smith, Buddhima K. P. Maldeni Kankanamalage, Serena M. Jentz, Natalia B. Shustova
The first overview of MOF thermodynamics is presented with respect to current applications, addressing global challenges.
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Recent advances in the strain-release driven reactions of bicyclobutanes: an emerging landscape in organic synthesis

Chem. Soc. Rev., 2026, 55,5572-5589
DOI: 10.1039/D6CS00010J, Tutorial Review

Shiksha Deswal, Rohan Chandra Das, Akkattu T. Biju
This tutorial review provides an overview of the important structural features and reactivity modes of BCBs and delves deep into the recent advances in BCB chemistry for the synthesis of bicyclic scaffolds and functionalized cyclobutanes.
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Cluster-based materials: design and applications

Chem. Soc. Rev., 2026, 55,5642-5668
DOI: 10.1039/D5CS00663E, Review Article

Open Access

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Hong Fang, Qiang Sun, Puru Jena
Polyatomic clusters and their derived materials constitute an interdisciplinary field with broad applications, bridging chemistry, physics, biomedicines, and materials sciences.
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Spin polarization and chemical catalysis: what we know, what works, and what's next

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00239G, Review Article

Junxian Liu, Ting Liao, Zhongfang Chen, Liangzhi Kou
Spin polarization offers a powerful lever for catalysis by tuning d-band levels, e_g occupancy, carrier separation, and spin filtering, enabling advances in HER, OER, ORR, CO₂RR, ammonia synthesis, and CO oxidation.
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Intelligent catalysis: on-demand dynamic self-optimization via responsive feedback

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01292A, Tutorial Review

Linbo Jiang, Shichun Mu
This review investigates intelligent self-optimization effects, responsive mechanisms and multimodal intelligent catalysis, associated challenges and solutions, aiming to promote on-demand applications in complex multi-scenario environments.
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Strong exciton coupling: a practical toolbox for computing interaction energies, wavefunctions, and optical spectra

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00157B, Tutorial Review

Open Access

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Rasmus Ringström, S. Rasoul Hashemi, Yuanxin Liang, Nicholas J. Hestand, Karl Börjesson
This review presents a practical toolbox for modelling exciton coupling in molecular aggregates, from Coulombic interactions and vibronic coupling to charge-transfer effects.
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An overview of reaction outcome prediction with physics-based and data-driven methods

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00079G, Review Article

Open Access

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Joonyoung F. Joung, Nicholas Casetti, Priyanka Raghavan, Connor W. Coley
Reaction outcome prediction can be formulated in multiple ways, spanning physics-based exploration of reaction pathways and data-driven prediction of product likelihoods.
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Switchable and biodegradable nanostructures for safe and precise tumor diagnostics

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00925A, Tutorial Review

Rebeka Rita Reszegi, Wenyao Zhen, Xiaoyuan Chen, Jingjing Zhang
This tutorial review outlines design principles for switchable and biodegradable nanostructures in cancer imaging, with emphasis on activation, stability, and clearance.
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How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01387A, Review Article

Open Access

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Douglas B. Kell, Ivayla Roberts
Rugged protein fitness landscapes can be learned from sparse sequence–activity data. Machine learning plus extreme-value theory can guide directed evolution toward rarer, higher-activity variants.
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Single crystal covalent organic frameworks

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00526D, Review Article

Open Access

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Yongzhi Chen, Zhihao Zhang, Donglin Jiang
This review maps strategies to achieve single crystal COFs, outlining methodological developments toward precise crystallization control and linking structure integrity with enhanced properties and advanced functional applications.
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Pore engineering in crystalline frameworks: from MOF “chemistry” to HOF “mechanics” for advanced drug delivery

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00465B, Review Article

Ke Jiang, Zhining Yuan, Ling Zhang, Banglin Chen, Guodong Qian
Pore engineering bridges MOF chemistry and HOF mechanics, enabling chemically and mechanically gated crystalline frameworks for precision drug delivery.
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Emerging porous materials for cell encapsulation

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D4CS00071D, Review Article

Open Access

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Francesco Carraro, Miriam de J. Velásquez-Hernández, Anita Emmerstorfer-Augustin, Daniel Kracher, Qilu Wu, Robert Kourist, Lien-Yang Chou, Ju Ge, Fa-Kuen Shieh, Christian Doonan, Paolo Falcaro
This review summarizes recent advances in cells@MOFs, cells@COFs, and cells@HOFs: synthesis strategies, cell–framework interactions, viability assessment, and advanced biotechnological applications.
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Chemical insights on covalent organic frameworks for ferroptosis and pyroptosis in cancer

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01295C, Tutorial Review

Eunji Kim, Min-Goo Lee, Yoonji Heo, Sumin Kim, Jiwoo Seo, Sungwook Jung, Jong Seung Kim, Min Kim
Covalent organic frameworks (COFs), with their customizable structures and properties, can be employed as comprehensive platforms to induce ferroptosis and pyroptosis.
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Circularly polarized luminescence in chiral hybrid metal halides

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00132G, Tutorial Review

Yi Wei, Huimin Kang, Yuxuan Wang, Yulian Liu, Zewei Quan
Chiral hybrid metal halides are promising circularly polarized luminescence materials with high emission efficiency and large dissymmetry factor. This review summarizes CPL generation, amplification strategies, and emerging applications.
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Correction: The long road to outdoor stability: real-world challenges for controlling perovskite materials for solar cells

Chem. Soc. Rev., 2026, 55,5561-5561
DOI: 10.1039/D6CS90039A, Correction

Open Access

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Juan José Patiño López, Kelly G. Rivera Botia, Kevin Ballestas, Esteban Velilla, Juan Felipe Montoya, Franklin Jaramillo, Daniel Ramirez
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Harnessing rare earth coordination chemistry for advanced photofunctional materials: from fundamental principles to emerging technologies

Chem. Soc. Rev., 2026, 55,5117-5197
DOI: 10.1039/D5CS00384A, Review Article

Fu-Jia Song, Pingru Su, Xue Li, Chun-Hua Yan, Jun-Long Zhang, Yu Tang
Harnessing RE coordination chemistry, antenna effects, and ligand engineering, this review establishes ligand–RE³⁺ structure–property correlations, outlines photofunctional strategies, and bridges fundamentals to emerging technologies.
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Harnessing biosynthetic logic for next-generation ADC payloads

Chem. Soc. Rev., 2026, 55,5530-5560
DOI: 10.1039/D5CS01487E, Review Article

Miaomiao Cai, Xinyuan Pan, Wei Shen, Sihui Bian, Dongbin Hu, Zhao-Xun Liang, Yu Tang, Xiaohui Fan, Guang-Lei Ma
This review explores how decoding nature's biosynthetic logic is transforming ADC payload innovation, from natural metabolites to clinical candidates, through genome-enabled discovery, scalable manufacturing, and emerging nontraditional modalities.
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Ternary organic solar cells: optimizing the third components

Chem. Soc. Rev., 2026, 55,5005-5038
DOI: 10.1039/D5CS00964B, Tutorial Review

Pachaiyappan Murugan, Yu-Long Peng, Shi-Yong Liu, Hongzheng Chen
This review highlights recent advances in T-OSCs based on NFAs, exploring material design, operational mechanisms, and morphology control to achieve efficiencies of >21%. Critical challenges and pathways toward commercial viability are discussed.
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Non-isocyanate polyurethane foams: where we stand and what comes next?

Chem. Soc. Rev., 2026, 55,4960-5004
DOI: 10.1039/D5CS00144G, Tutorial Review

Open Access

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Bruno Grignard, Maxime Bourguignon, Florent Monie, Thomas Vidil, Henri Cramail, Gabriel Perli, Haritz Sardon, Jean-Marie Raquez, Sylvain Caillol, Christophe Detrembleur
Spotlight on non-isocyanate polyurethane foams: fabrication, utilization and end-of-life. This tutorial review highlights how they differ from traditional PU foams and the key challenges to competitiveness.
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Ferroelectric materials in rechargeable batteries

Chem. Soc. Rev., 2026, 55,5491-5529
DOI: 10.1039/D6CS00069J, Review Article

Weizhong Liang, Yu You, Ziqin Liu, Kunyun Yan, Jialin Lin, Yongheng Wu, Qiwei Yu, Kun Zhao, Xiaowei Huang, Chunxiao Zhang, Jun Liu, Weifeng Wei
Ferroelectric materials introduce internal electric fields that regulate ion transport, interfacial charge distribution and electrochemical reactions. They can mitigate polarization, stabilize interfaces and enhance cycle life of advanced batteries.
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The design and development of glucose probes for sensing and imaging within biological systems

Chem. Soc. Rev., 2026, 55,5403-5490
DOI: 10.1039/D3CS00795B, Review Article

Open Access

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Hao Wang, Chunfang Li, Fangyuan Zhang, Benjamin Kersch-Hunt, Jordan E. Gardiner, Lijuan Ren, Ying Li, Simon E. Lewis, Yanling Mu, Qingqiang Yao, Luling Wu, Robin R. Groleau, Wenhao Zhai, Zhen Liu, Tony D. James, Eric V. Anslyn, Kai Wang
Glucose and its homeostasis are crucial to biological regulation, making the development of probes for glucose sensing and imaging a long-standing priority in biological and chemical research.
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Various energy-driven high-value-added oxidation reactions in CO2 reduction systems

Chem. Soc. Rev., 2026, 55,4939-4959
DOI: 10.1039/D5CS00941C, Tutorial Review

Jinyu Ding, Peijin Du, Mengqian Li, Dongpo He, Qinyuan Hu, Qingxia Chen, Xingchen Jiao, Yi Xie
We summarize a timely and in-depth survey on the development of high-value alternative oxidation reactions to the OER in CO₂ reduction, including photocatalytic, electrocatalytic and multi-energy-driven catalytic CO₂ reduction.
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Catalytic asymmetric [4+2] cycloadditions of unsaturated hydrocarbons by transition metal catalysis and photocatalysis

Chem. Soc. Rev., 2026, 55,5198-5226
DOI: 10.1039/D5CS01218J, Review Article

Open Access

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Jun-Xiong He, Quan Cai
This review highlights recent progress in asymmetric [4+2] cycloadditions of alkenes, alkynes, and allenes by transition-metal catalysis and photocatalysis beyond the conventional Diels–Alder reaction.
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Electrocatalytic amine dehydrogenation as a green route to nitriles: precise construction of efficient catalysts and mechanism

Chem. Soc. Rev., 2026, 55,4911-4938
DOI: 10.1039/D5CS01445J, Tutorial Review

Long Chen, Wen-Ping Zhang, Hao Tan, Yu-Ping Zhang, Shuo Sun, Yan-Cheng Zhu, Zhao-Hua Yin, Hong Liu, Jian-Jun Wang
This review outlines nitrile synthesis methods, highlighting recent progress in electrocatalytic amine dehydrogenation to nitriles, with a focus on catalyst design, mechanistic understanding, system optimization, key challenges and future prospects.
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Emerging deposition–dissolution chemistry for next-generation metal-based hybrid flow batteries: progress and perspectives

Chem. Soc. Rev., 2026, 55,5332-5402
DOI: 10.1039/D5CS01418B, Review Article

Jie Wei, Jingjie Sun, Sijia Bai, Liuxin Ding, Pengbo Zhang, Yixing Wang, Yuzhu Liu, Kang Huang, Zhong Jin, Zhi Xu
This review provides a comprehensive analysis of the family of metal-based hybrid flow batteries based on deposition–dissolution chemistry, including fundamental principles, advancements in core components, and future research directions.
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Advanced high-entropy materials for fuel cells and water electrolysis

Chem. Soc. Rev., 2026, 55,5269-5331
DOI: 10.1039/D5CS01274K, Review Article

Minyuan Liu, Xiaoyan Luo, Guoqing Wang, Gebrehiwot Gebreslassie, Halefom G. Desta, Jianjian Zhang, Bin Lin, Wei Yan, Jiujun Zhang
High-entropy materials (HEMs) represent a paradigm shift in developing efficient components of proton exchange membrane fuel cells/water electrolysis and solid oxide fuel cells/water electrolysis for hydrogen energy conversion and storage.
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Advances in intelligent multi-mode lateral flow assays: from multi-metallic nanomaterials to smart analytical integration

Chem. Soc. Rev., 2026, 55,5039-5079
DOI: 10.1039/D5CS00963D, Review Article

Open Access

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Xinyi Liang, Hayoung Kim, Thanh Mien Nguyen, Kun Wang, Chengcheng Li, Seunghyun Lee, Jingbin Zeng, Jaebum Choo
This review highlights intelligent, multi-metallic nanoparticle-based LFAs integrated with AI. It outlines their potential for data-driven, personalised point-of-care diagnostics.
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Dynamic interfaces in metal–organic frameworks

Chem. Soc. Rev., 2026, 55,5227-5268
DOI: 10.1039/D5CS01236H, Review Article

Yuanjie Cao, Reza Abazari, Qipeng Li, Jinjie Qian
This review deconstructs the dynamic interfaces in MOFs across (i) SBU, (ii) ligand, and (iii) framework interfaces. These interfacial insights establish a structure–dynamics–function paradigm for the design of multifunctional MOFs.
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Advances in heterochromophoric perylene bisimide self-assemblies towards supramolecular electronics

Chem. Soc. Rev., 2026, 55,5080-5116
DOI: 10.1039/D5CS01401H, Review Article

Vidushi Gupta, Samaresh Samanta, Sanchita Sengupta
Perylene bisimide (PBI) dyes owing to their exceptional photophysical features are well-suited for supramolecular electronics. Heterochromophoric PBI assemblies in solution are discussed, focussing on their optical and electronic applications.
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Surface and interface atomic engineering of ultrathin 2D inorganic materials for small molecule photocatalysis

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00318D, Tutorial Review

Juncheng Zhu, Zijia Lin, Yang Wu, Yongfu Sun, Yi Xie
This review categorizes modification strategies into surface and interface atomic engineering and systematically elucidates their impacts on electronic structures and photocatalytic performances.
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Tissue-bioelectronics interfaces

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01422K, Review Article

Jiahong Li, Jin Qu, Wei Gao
A mechanism-driven framework for tissue–bioelectronics interfaces, integrating interfacial mechanisms, materials, structural design and fabrication to enable stable, conformal bioelectronic systems for continuous monitoring and therapy.
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