RSC - Food Funct. latest articles

Blueberry anthocyanin-pretreated Akkermansia muciniphila enhances probiotic efficacy against metabolic syndrome via gut microbiota remodeling and hepatic signaling modulation

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01106C, Paper

Lanlan Du, Weichen Zhang, Zhen Tang, Shiyu Chu, Xinyu Gu, Xiaoqin Ding, Tunyu Jian, Yanan Gai, Jian Chen, Weilin Li
Targeting the gut microbiota is a promising strategy for treating metabolic syndrome (MetS). Previous studies have shown that dietary components, including polyphenols and dietary fibers, can modulate the abundance of...
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Coffee alleviates anxiety-like behavior and metabolic dysfunction induced by combined high-fat diet and sleep deprivation in mice: a multi-omics analysis of alterations associated with the gut–liver–brain axis

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01189F, Paper

Wenting Li, Hui-Bin Jiang, Wei Fenfen, Zihan Lin, Yan Wu, Ying Wang, Lihua Song
A high-fat diet (HFD) combined with sleep deprivation (SD) (collectively termed HSD) is a common modern lifestyle stressor that induces metabolic dysfunction and neurobehavioral alterations. Here, we investigated whether daily...
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Linkage-dependent effects of procyanidin dimers on TNFα-mediated intestinal epithelial barrier dysfunction, redox homeostasis and inflammation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO02097F, Paper

Wei Zhu, Patricia I. Oteiza
Procyanidin dimers protect intestinal barrier function by restoring redox homeostasis and suppressing inflammation in a linkage-dependent manner.
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Unleash the power of citrus: functional activity and delivery of citrus secondary metabolites

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04960A, Review Article

Aiyang Liu, Ruoyun Zhang, Yunshan Cheng, Ying Wang, Zhangshuang Deng
Citrus secondary metabolites are extracted, quantified, and encapsulated in delivery systems to improve stability, bioavailability, and health benefits for functional food and nutraceutical applications.
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Bifidobacterium longum subsp. infantis CCFM1269 alleviates neonatal maternal separation-induced colic in rats by regulating serotonin metabolism, NGF/TrkA signaling pathway and gut microbiota

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO02711C, Paper

Hongyu Wang, Renqiang Yu, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Wei Chen, Bo Yang
Infantile colic (IC), a common functional gastrointestinal disorder in early life, affects approximately 20% of infants worldwide and is associated with long-term health risks; nevertheless, effective interventions remain limited. This...
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Moderate consumption of a polyphenolic-enriched wine attenuates alcohol-associated alterations in hepatic biomarkers in overweight subjects: a randomized clinical trial

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01211F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

I. Urquiaga, Gerard Casaubon, Druso Pérez, Daniela Sara, Pierre-Louis Teissedre, Felipe Avila
Moderate red wine consumption has been associated with cardioprotective effects, which have been partly attributed to its polyphenolic content. However, human intervention studies remain limited, particularly regarding polyphenol-enriched wines with...
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Oyster-derived peptide DLAGRDLTDYLM attenuates dexamethasone-induced osteoporosis in rats: associations with lipid metabolism and bone remodeling signatures

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00926C, Paper

Wei Yang, Mingtang Tan, Haisheng Lin, Jialong Gao, Zhongqin Chen, Huina Zheng, Xiaoming Qin, Wenhong Cao, Di Wu
An oyster-derived peptide, DLAGRDLTDYLM, was screened via a zebrafish model. Its anti-osteoporotic mechanisms in rats were revealed through integrated multi-omics and targeted proteomics.
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Saturated alginate oligosaccharide as a new functional food: preparation, characterization and alleviation of cognitive impairment through pre-intervention

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01790H, Paper

Youjing Lv, Meng Shao, Zhiliang Fu, Depeng Lv, Qingsen Shang, Yue Yang, Chunlei Wang, Peng Guo, Shuang Lin, Xueyan Zhang, Xia Zhao, Guangli Yu, Quancai Li
SAOS ameliorated scopolamine-induced memory deficits in mice and rats by enhancing acetylcholine, alleviating oxidative stress, restoring Roseburia, and reversing reductions in serum N-arachidonoyl dopamine and cortical linoleoyl ethanolamide.
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Water- and alkali-extracted wheat bran polysaccharides differentially affect antiproliferative and cell death responses in HCT116 and HT29 cells

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01624C, Paper

Candela Paesani, Milena Fronza Broering, Gabriela T. Peréz, João Paulo Fabi
Wheat bran is a major by-product of cereal processing and a rich source of dietary polysaccharides with potential health-promoting properties.
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Unraveling corilagin's absorption and metabolism: a multimodal approach

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05706J, Paper

Shi-Dan Wang, Chen-Huan Qiao, Wen-Bo Feng, Tong Liu, Wei Lu, Ding-Hong Wu, Edidiong Uduak Johnson, Yu-Xin Chen
Corilagin is an ellagitannin, a natural product found in a wide variety of foods, but its absorption and utilization process in the mammalian intestine is still unclear.
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Ultra-processed food consumption and the trajectory of cardio-renal-metabolic multimorbidity: insights from multi-state modelling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00970K, Paper

Shuzhen Zhao, Chengnan Guo, Xin Zhang, Yi Li, Jingkun Hu, Jiayi Huang, Luojia Dai, Zhenqiu Liu, Tiejun Zhang
Higher intake of ultra-processed foods is associated with sequential cardio-renal-metabolic multimorbidity, whereas replacing them with unprocessed or minimally processed foods is linked to a lower risk of progressing to severe multimorbidity.
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Cinnamaldehyde, a major bioactive component of cinnamon bark, enhances social approach behavior associated with a liver–brain FGF21–isotocin axis in zebrafish

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00815A, Paper

Yukiko Nishi, Momoko Kawabe, Seiwa Michihara, Shigeki Chiba, Yuko Kamada-Futagami, Toshiki Hyodo, Akio Inui, Kazuhiro Shiozaki
Cinnamaldehyde, a major compound in cinnamon bark, enhanced heterospecific social interaction in zebrafish. These effects were associated with increased hepatic Fgf21 expression and activation of brain isotocin- and GABA-related signaling pathways.
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Pumpkin (Cucurbita maxima) seed extract ameliorates letrozole and high-fat diet-induced PCOS in rats via SIRT1/AMPK/NF-κB signaling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00600K, Paper

Suhasini Sidrameshwar, Asha Martin
PCOS ameliorative effects of pumpkin seed extract.
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Multi-omics integration reveals that pterostilbene ameliorates cyclophosphamide-induced liver injury via the gut-liver axis by inhibiting inflammation and oxidative stress

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01629D, Paper

Huijie Gao, Qi Zhang, Yani Zhu, Yueying Li, Kunzheng Fan, Yuewen Gao, Chao Liu
Cyclophosphamide (CTX) is a commonly used immunosuppressant and chemotherapeutic drug, yet its clinical application is often restricted by drug-induced liver injury (DILI). Pterostilbene (PTS), a dietary polyphenol abundant in blueberries...
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Myofibrillar protein-based matrices are associated with altered intestinal lipid handling and enterohepatic signalling in adolescent female mice

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01317A, Paper

Meng Zhou, Mengzhen Ding, Lili Wu, Kun Yang, Hui He, Chunbao Li
Dietary lipids are typically ingested within complex protein-lipid matrices, where the protein source serves as a primary determinant of lipid digestion and bioavailability. However, the role of myofibrillar proteins, which...
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Genetic Variants Modulate Effects of EGCG on Adiposity and Insulinemia in Diversity Outbred Mice

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00791K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Dragan Milenkovic, Romit Seth, Michael G. Sweet, Lisard Iglesias Carres, Andrew Peter Neilson
Dietary polyphenols have been studied for their potential to mitigate cardiometabolic disease risk; however, their metabolic effects show significant interindividual variability. While factors such as sex, age, health status or...
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Bound polyphenols from carrot dietary fiber delay aging in Caenorhabditis elegans through the IIS pathway and metabolic remodeling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO02372J, Paper

Jinghan Feng, Bing Zheng, Ye Hui, Jianhua Xie, Yi Chen, Xinyi Chen, Xiaobo Hu, Danyang Liu, Ruihong Dong, Qiang Yu
In this study, bound polyphenols from carrot dietary fiber, referred to as CDF-BP, were investigated for their anti-aging activity in Caenorhabditis elegans.
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Dietary 1,3-diacylglycerols rich in γ-linolenic and stearidonic acids improve metabolic parameters and tissue lipid profiles in high-fat diet-induced obese mice

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01924B, Paper

Rodrigo Valenzuela, Camila Farias, Yasna Muñoz, Ignacio Alvear, Alejandra Espinoza, Adriano Costa de Camargo, Sandra López-Arana, Miguel Ángel Rincón-Cervera
Structured lipids (SLs) enriched in γ-linolenic acid (GLA) and stearidonic acid (SDA) were synthesized as 1,3-diacylglycerols (1,3-DAGs) and evaluated in a high-fat diet (HFD)-induced obesity mouse model. Male C57BL/6J mice...
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Fucoxanthin enhances AMPK/mTOR-dependent autophagic flux and attenuates ferroptosis in Alzheimer's disease models

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01264G, Paper

Nayoung Lee, Kumju Youn, Minho Moon, Dong-Seok Lee, Dong Hyun Kim, Chi-Tang Ho, Mira Jun
Fucoxanthin reduced amyloid pathology through autophagy–lysosomal modulation and attenuation of ferroptosis-associated lipid peroxidation.
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Gut microbiota-dependent metabolism of 6-shogaol generates bioactive metabolites that mediate its anti-inflammatory effects

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01722C, Paper

Shuwei Zhang, Yantao Zhao, Rachel C. Newsome, Yingdong Zhu, Christian Jobin, Shengmin Sang
This study provides in vivo evidence that gut microbiota is a central determinant of both the metabolic fate and anti-inflammatory efficacy of 6-shogaol.
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Lactiplantibacillus plantarum KLDS1.0344 ameliorates depressive-like behavior in CUMS mice: integrative multi-omics evidence linking gut microbiota alterations to sphingolipid and glycerophospholipid metabolic pathways

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00143B, Paper

Fangfei Dou, Yuxing Li, Wenqing Lv, Yuqi Sun, Meiqi Li, Bailiang Li, Yupeng Wang, Wei Yu
L. plantarum KLDS1.0344 alleviates CUMS-induced depressive-like behaviors in mice via reduced HPA-axis hormones, restored monoamine neurotransmitters and BDNF, remodeled gut microbiota, and altered sphingolipid/glycerophospholipid metabolism.
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Association between daidzein metabolism to equol and fecal bile acid profiles in young women

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01483F, Paper

Naho Mizuno-Nagata, Hitoshi Ashida, Toshiya Toda
Bile acids are a critical factor influencing equol production in humans.
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Mimicking human milk functions: the human milk oligosaccharide building block GlcNAc in combination with GOS protects the intestinal barrier

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO02196D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sonia Kassai, Paul de Vos
A combination of GlcNAc and GOS has a protective effect on TEER when used to pretreat cells before A23187 exposure.
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Anti-inflammatory activity of orange peel aqueous extract and hesperidin: integrated evidence from neutrophil assays, in vivo models, and in silico analyses

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00864J, Paper

Tinhinane Rekeb, Samia Bedouhene, Nassima Senani, Sahra-Amel Belambri, Meriem-Dehbia Chabane, Riadh Ksouri, Pham My-Chan Dang, Jamel El Benna
Orange peel aqueous extract and its major compound hesperidin inhibit neutrophil oxidative burst, MPO release, and chemotaxis, reducing inflammation in a rat pleurisy model.
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Lactobacillus_rhamnosus GG reverses zearalenone-induced pathological macrophage polarization to restore placental angiogenesis and efficiency

Food Funct., 2026, 17,5425-5438
DOI: 10.1039/D6FO00618C, Paper

Peiqiang Yuan, Bin Feng, Yan Lin, Shengyu Xu, Lun Hua, Yong Zhuo, Lianqiang Che, De Wu, Zhengfeng Fang
Zearalenone (ZEN) induced abnormal M2-type polarization of placental macrophages, impaired placental angiogenesis and efficiency. Lactobacillus rhamnosus GG alleviated ZEN-induced placental damage by altering macrophage polarization.
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Akkermansia muciniphila alleviates diabetic cognitive impairment by inhibiting NLRP3 inflammasome activation and ameliorating hippocampal synaptic defects

Food Funct., 2026, 17,5738-5755
DOI: 10.1039/D5FO03902A, Paper

Yage Du, Yu An, Zhaoming Cao, Guangyi Xu, Ming Chu, Yanhui Lu
This study demonstrates that the probiotic Akkermansia muciniphila alleviates diabetic cognitive impairment by inhibiting NLRP3 inflammasome activation and improving synaptic function in mice, revealing a novel therapeutic strategy.
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Adhering to dietary guidelines does not yield flavanol intake levels associated with beneficial cardiovascular effects

Food Funct., 2026, 17,5715-5725
DOI: 10.1039/D6FO00867D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Javier I. Ottaviani, John W. Erdman, Francene M. Steinberg, JoAnn E. Manson, Howard D. Sesso, Hagen Schroeter, Gunter G. C. Kuhnle
Adherence to dietary guidelines does not yield flavanol intakes comparable to those shown to provide cardiovascular benefits in COSMOS. Dietary reference values for flavanols may be necessary to increase the intake of these dietary compounds.
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Polyphenol combinations improve quercetin absorption and inhibit carbohydrate digestion while reducing glucose transport

Food Funct., 2026, 17,5704-5714
DOI: 10.1039/D6FO00569A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

C. G. M. Dohmen, M. M. J. P. E. Sthijns, R. Slotboom, F. J. Troost
High sugar intake promotes obesity and type 2 diabetes. Quercetin potently inhibits α-glucosidase and reduces glucose uptake. Polyphenol mixtures enhance α-amylase inhibition, increase quercetin absorption, without effecting fructose transport.
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The effect of high-protein vs. low-protein diets on CRP, IL-6, TNF-α, and liver enzymes in adult participants: a systematic review and meta-analysis

Food Funct., 2026, 17,5360-5377
DOI: 10.1039/D5FO04706D, Review Article

Xue Ma, Pejman Rohani, Mohammad Hassan Sohouli
High-protein diets (HPDs) are widely recommended for weight management and preservation of lean mass, but their impact on systemic inflammation and liver health remains controversial.
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Chloroplasts as ingredients for food: a review

Food Funct., 2026, 17,5333-5359
DOI: 10.1039/D5FO03797B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

David A. Gray, Poramat Sutcharit, Jutarat Wattanakul, Mohamed A. Gedi, Ruth Price, Ardeshir Farmanfarmaian, Randa Darwish, Syamila Mansor, Chao Chi, Malgorzata Walczak, Rhianna Briars, Joshua E. S. J. Reid, Vincenzo Di Bari, Joanne Gould, Molly Muleya, Robert Rintoul, Lorna Mcausland, Moulay Sahaka, Frédéric Carrière
The chloroplast is best known for its role in photosynthesis, the process by which sunlight energy is converted into chemical energy in the form of sugar. This image is created using Biorender.
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Correction: Genetic risk modifies the effect of exogenous nucleotides on insulin resistance in older adults: insights from multi-omics analyses

Food Funct., 2026, 17,5770-5770
DOI: 10.1039/D6FO90042A, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ruisheng Fu, Shuyue Wang, Yuxiao Wu, Xueying Qin, Tao Huang, Yong Li, Meihong Xu
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Advances in starch-based binary and ternary complexes with lipids and proteins: mechanisms, digestibility, and applications in low-glycemic foods

Food Funct., 2026, 17,5296-5332
DOI: 10.1039/D6FO00809G, Review Article

Feng Mei, Wang Ping-Ping, Fu Xiong, Chen Chun
Multi-scale defense mechanisms of starch–lipid–protein complexes against enzymatic digestion. The ternary complex suppresses starch digestion via a series of multi-level defense mechanisms spanning from the macroscopic to the molecular level.
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Phyllanthus emblica L. polysaccharides attenuate anxiety disorder-like behavior in high-fat diet-fed mice

Food Funct., 2026, 17,5726-5737
DOI: 10.1039/D6FO01214K, Paper

Yu-Tien Huang, Sheng-Yi Chen, Yi-Hsien Hsu, Gow-Chin Yen
Phyllanthus emblica L. polysaccharides (PEP) reduce anxiety disorder-like behavior by inhibiting inflammatory pathways (TLR4, MyD88, NF-κB) and dual-regulating the AMPK/mTOR axis in high-fat diet-fed mice.
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Mediterranean diet adherence and dietary fat intake in relation to lung cancer outcomes: a prospective cohort study

Food Funct., 2026, 17,5650-5661
DOI: 10.1039/D6FO00080K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Qiyun Xue, Huakang Tu, Yan Liu, Shiyu Jiang, Lizhi Zhang, Fang Hu, Qingfeng Hu, Min Yang, Xifeng Wu
Adherence to the Mediterranean diet and higher polyunsaturated fatty acid intake independently relate to lower lung cancer risk and mortality. Their combination may provide additional benefits for lung cancer post-diagnosis survival.
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The importance of oral processing of bean-based wraps with different microstructures on starch digestion: an in vivo and in vitro study

Food Funct., 2026, 17,5634-5649
DOI: 10.1039/D6FO00876C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Esther Staes, Dorine Duijsens, Serafien Lefever, Lieza Theuwissen, Masha Mikhalski, Ann Van Loey, Tara Grauwet
How does oral processing affect starch digestion in bean-based wraps?
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Oleuropein and hydroxytyrosol enhance mitochondrial function and biogenesis in SH-SY5Y cells through estrogen-like mechanisms

Food Funct., 2026, 17,5598-5620
DOI: 10.1039/D6FO00178E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Manuela Leri, Daniele Nosi, Diletta Ami, Federica Bovio, Matilde Forcella, Federica Carnemolla, Paolo Mereghetti, Paola Fusi, Antonino Natalello, Massimo Stefani, Niccolò Taddei, Monica Bucciantini
EVOO-derived OleA and HT activate estrogen-like neuroprotective pathways, enhancing mitochondrial fitness, metabolic efficiency, and neuronal survival against age-related decline.
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3-Fucosyllactose and 3′-sialyllactose combined with Lacticaseibacillus rhamnosus 1.0320 alleviate necrotizing enterocolitis by modulating the gut microbiota and regulating NF-κB/Nrf2 pathways

Food Funct., 2026, 17,5567-5584
DOI: 10.1039/D5FO05215G, Paper

Juncai Hou, Xiaolei Duan, Hao Shi, Jing Zhang, Zhanmei Jiang, Zhongmei Tan, Zihao Tian, Xiangyu Li, Qingyun Wang
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease that primarily affects premature infants.
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Yellow tea extract ameliorates dexamethasone-induced hepatic steatosis by modulating the gut–liver axis and reshaping microbial metabolites: a multi-omics insight

Food Funct., 2026, 17,5410-5424
DOI: 10.1039/D6FO01620K, Paper

Pengfei Ren, Zhipeng Kan, Biqian Wei, Wanting Qin, Shangyun Lu
Multifaceted protection via the gut–liver axis.
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Pomelo-derived exosomes suppress vesicular stomatitis virus infection through GSK3β dependent regulation of innate immune signaling

Food Funct., 2026, 17,5548-5566
DOI: 10.1039/D6FO00968A, Paper

Zhanzhi Ren, Lishan Huang, Dan Guo, Chengyu Li, Jing Zhang, Huaming Tao, Xingang Yao, Wenyu Wu
Pomelo-derived extracellular vesicles, especially after sodium alginate encapsulation, show anti-VSV activity and may regulate GSK3β/STAT1-related innate immune signaling.
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Sulforaphane reprograms the metabolomic landscape of chronic kidney disease: insights from NMR-based metabolomics

Food Funct., 2026, 17,5538-5547
DOI: 10.1039/D6FO00047A, Paper

Marcia Ribeiro, Ludmila F. M. F. Cardozo, Natália A. Borges, Larissa Manhães, Aline D. Pereira, Mauricio Luis Sforça, Gustavo H. Rodrigues da Silva, Denise Mafra
Chronic kidney disease (CKD) promotes metabolic dysregulation. Sulforaphane supplementation modulates metabolic pathways and antioxidant defenses, suggesting a potential therapeutic strategy to improve metabolic alterations in CKD.
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Dietary polyphenols as modulators of the microbiota–gut–brain axis in depression and anxiety: a preclinical perspective

Food Funct., 2026, 17,5254-5295
DOI: 10.1039/D5FO05615B, Review Article

Levi Nascimento Bellinazzi, Iara Lopes Lemos, Agatta Caroline de Souza, Giulianna Genizelli, Angela Giovana Batista, Mario Roberto Marostica Junior
Dietary polyphenols modulate gut microbiota, increasing SCFAs and reducing inflammation. Through the gut–brain axis, they preserve gut barrier integrity, attenuate neuroinflammation, and improve neurotransmission and behavior.
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Effects of different proportions of structural fats on cognitive function and body weight in mice

Food Funct., 2026, 17,5478-5490
DOI: 10.1039/D5FO05678K, Paper

Quanzhang Li, Ting Li, Suqi Wei, Meng Wei, Sufang Duan, Zeyuan Deng, Jing Li
Human milk's unique triglyceride composition modulates lipid metabolism, reducing weight gain and enhancing cognition in mice, offering insights for improved infant formula design.
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Quercetin attenuates neutrophil extracellular trap formation in uveitis through orchestrating the cGAS–STING signaling pathway

Food Funct., 2026, 17,5462-5477
DOI: 10.1039/D6FO00799F, Paper

Congling Wang, Bin Liu, Yuecong Sun, Yuan Peng, Yane Gao, Huixia Wei, Bo Bao, Xuewei Yin, Hongsheng Bi, Dadong Guo
Quercetin attenuates NET formation in uveitis by regulating the cGAS–STING pathway.
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Immunomodulatory effect of rice bran peptides on RAW264.7 cells

Food Funct., 2026, 17,5449-5461
DOI: 10.1039/D6FO01738J, Paper

Wei Lin, Xinlai Sui, Xiaolan Liu, Xiqun Zheng
Rice bran peptides (RBPs) activate macrophages and enhance phagocytosis, demonstrating potential as novel dietary immunomodulators for improving immune function.
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Goal orientation is a key determinant of healthy dietary behaviour change in European adults receiving personalised vs. non-personalised nutrition advice

Food Funct., 2026, 17,5439-5448
DOI: 10.1039/D5FO03197D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mariette Abrahams, Brendan P. Bunting, Lynn J. Frewer, Katherine M. Livingstone, John C. Mathers, Barbara J. Stewart-Knox
Although personalised nutrition is more effective than generic approaches to dietary health promotion, effect sizes tend to be small.
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Microbiota dynamics and their impact on the metabolite in lupin oat yoghurt analogues

Food Funct., 2026, 17,5673-5689
DOI: 10.1039/D5FO05594F, Paper

Damodar Dhakal, Zijian Liang, Pangzhen Zhang, Jeremy J. Barr, Dinesh Subedi, Sushil Dhital
The growing demand for nutritious, flavour-rich plant-based yoghurt analogues calls for innovative fermentation strategies.
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Daily supplementation with egg yolk lipids from two eggs alleviated cognitive impairment in 5 × FAD mice by restoring neuronal and synaptic function and regulating gut microbiota

Food Funct., 2026, 17,5690-5703
DOI: 10.1039/D6FO00928J, Paper

Le Cheng, Yifei Wang, Yumeng Ma, Chenyan Zheng, Zihan Wang, Fang Wu, Bing Fang
DHA-enriched egg yolk lipids (two eggs daily) alleviate 5 × FAD mouse cognitive deficits by promoting neuronal survival, improving synaptic plasticity, suppressing neuroinflammation, and remodeling gut microbiota and neuroprotective metabolites.
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A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of chronic oyster mushroom intervention in healthy older adults

Food Funct., 2026, 17,5621-5633
DOI: 10.1039/D5FO04951B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sara Cha, Lynne Bell, Jessica Eastwood, Derek R. Fisher, Barbara Shukitt-Hale, Zicheng Zhang, Ana Rodriguez-Mateos, Claire M. Williams
Pleurotus ostreatus oyster mushrooms demonstrate potential to maintain mood, improve memory, and reduce inflammation in older adults.
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An innovative germination-driven LAB fermentation strategy for allergenicity reduction in soymilk gels through spatiotemporal protease-mediated epitope disruption

Food Funct., 2026, 17,5756-5769
DOI: 10.1039/D5FO04998A, Paper

Yaqiong Wang, Shijie Fang, Zhihao Fan, Yi Wang, Yue Wu, Xin Rui, Pei Wang, Chong Xie, Runqiang Yang
This study innovatively integrated seed germination (1–3 days) with LAB fermentation to establish a structure–immunomodulation nexus in fermented soymilk gels.
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Impact of tomatoes and tomato-derived products on obesity and cardiometabolic health: a systematic review and meta-analysis

Food Funct., 2026, 17,5213-5232
DOI: 10.1039/D6FO00495D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lea Sani, Lourdes Mounien, Jean-François Landrier
This article provides modest but biologically consistent evidence on the role of tomato and tomato-based product intake on several parameters linked to adiposity and obesity.
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Neochlorogenic acid attenuates endothelial injury in diabetic ApoE−/− mice by suppressing NF-κB mediated NLRP3 inflammasome activation

Food Funct., 2026, 17,5506-5520
DOI: 10.1039/D6FO00170J, Paper

Yung-Che Tsai, Kuei-Chuan Chan, I-Ning Tsai, Ping-En Ko, Hui-En Hsu, Meng-Hsun Yu, Chau-Jong Wang
Diabetes mellitus (DM) significantly increases global morbidity and mortality through cardiovascular complications, particularly atherosclerosis, characterized by chronic inflammation, oxidative stress, and endothelial dysfunction.
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Integrated RNA-seq and network pharmacology analyses suggest PI3K–Akt and NF-κB pathway modulation in the protective effects of diosmin against experimental colitis

Food Funct., 2026, 17,5521-5537
DOI: 10.1039/D6FO01388K, Paper

Shuo Wang, Cheng Tan, Haodong He, Xiangyun Li, Miao Xu, Xingzhou Guo, Yafei Liu, Fei Liao, Weiguo Dong
Ulcerative colitis (UC), a chronic inflammatory bowel disease, remains difficult to treat due to incomplete understanding of its mechanisms and limited therapeutic options.
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Association of ultra-processed foods (UPFs) with hypertriglyceridemic waist (HTGW) phenotype, oxidative stress, and inflammation in Iranian adults: a cross-sectional study

Food Funct., 2026, 17,5662-5672
DOI: 10.1039/D5FO05626H, Paper

Reyhane Rostamian, Mahdi Moabedi, Donya Poursalehi, Zahra Moradmand, Farnaz Shahdadian, Parisa Rouhani, Parvane Saneei
In this study, we evaluated the association between UPFs with HTGW in relation to oxidative stress and inflammation in Iranian adults, as no previous study had assessed these altogether.
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Metabolomic insights reveal bioactive enhancement in fermented oat-based beverages via Lactobacillus plantarum

Food Funct., 2026, 17,5585-5597
DOI: 10.1039/D6FO00493H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Aly Castillo, Matteo Capietti, Cristina Megias, Javier Olleros, Fabio Días, Bernardo Ordás, Gerardo Alvarez-Rivera, Marta Lores
This study evaluates the impact of thermal processing and fermentation with Lactobacillus plantarum on the bioactive composition and metabolic profile modulation of an oat-based (Avena sativa) beverage.
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Effects of perilla oil on platelet and inflammatory responses in healthy smokers: a randomized, double-blind, placebo-controlled, parallel trial

Food Funct., 2026, 17,5394-5409
DOI: 10.1039/D6FO01112H, Paper

Sehee Lee, Kyeong Jin Kim, Min Ju Park, Soo-yeon Park, Young-Jun Kim, Hyounggyoon Yoo, Ji Yeon Kim
8-week ALA-rich perilla oil supplementation increases blood omega-3 levels and modulates platelet and inflammatory responses in healthy smokers.
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Dihydromyricetin attenuates platelet hyperactivity in HFD/STZ-induced diabetic mice by inhibiting intraplatelet ROS generation

Food Funct., 2026, 17,5491-5505
DOI: 10.1039/D6FO00232C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Fenglin Song, Huafang Ding, Yun Chen, Xiangzhen Ge, Ruixue Guo, Fangfang Wu, Yu Guo, Ren-You Gan, Zhen-Yu Chen
Dihydromyricetin protects against diabetes-associated platelet hyperactivity and thrombosis through inhibition of intraplatelet ROS generation.
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From food plants to functional ingredients for type 2 diabetes: chemotype markers, digestive fate, exposure-informed specifications and sustainable processing

Food Funct., 2026, 17,5233-5253
DOI: 10.1039/D6FO00752J, Review Article

Ngoc Hong Nguyen, Thuc-Huy Duong, Nhat Thang Thi Nguyen, Huong Thuy Le, Giau Van Vo, Anh Duy Do
Edible plants modulate glycaemic control through coordinated gut and systemic mechanisms. Translation into functional ingredients requires linking of the chemotype, digestive fate, and exposure to mechanism-aligned clinical endpoints.
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Cynarin alleviates apical periodontitis by inhibiting macrophage M1 polarization via the PGC1α/ROS signaling axis

Food Funct., 2026, 17,5378-5393
DOI: 10.1039/D6FO00014B, Paper

Yao Yang, Min Li, Lifei Pan, Tiezhou Hou, Siyu Hou
Schematic representation of the mechanism by which cynarin attenuates the progression of AP.
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Efficacy of different dietary fibers for chronic idiopathic constipation: a systematic review and network meta-analysis

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00286B, Review Article

Jianjiao Mou, Lianlin Zeng, Yangan Li, Meng Sun, Qianlong Li, Kehui Hu, Qiong Wang
Viscous soluble fibers and insoluble fibers rank the highest in efficacy for improving bowel movements in chronic idiopathic constipation, based on a network meta-analysis of multiple fiber types.
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Outstanding Reviewers for Food & Function in 2025

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO90046A, Editorial

We would like to take this opportunity to highlight the Outstanding Reviewers for Food & Function in 2025, as selected by the editorial team for their significant contribution to the journal.
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Dietary purple sweet potato anthocyanin extracts attenuate intestinal barrier decline in naturally aged mice via the microbiota–autophagy–stem cell axis

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00039H, Paper

Yanpei Gu, Lulu Li, Haichao Zhang, Tong Ye, Qing Zhu, Xinru Zhao, Keqin Xie, Rui Ge, Jianzhong Han, Yumei Qin
Age-related deterioration of the intestinal epithelial barrier exacerbates systemic metabolic and functional decline, highlighting the gut as a key target for dietary interventions in healthy aging.
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Traditional fermented camel milk from Xinjiang, China, used as a starter culture exhibits stable fermentation characteristics and anti-colitis effects

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05107J, Paper

Fangnuo Deng, Dashuai He, Guangqing Mu, Xinling Li, Yanfeng Tuo
Xinjiang fermented camel milks' microbiota, amino acids, and peptides were characterized. Their fermentation stability and protective effects against colitis were validated, highlighting their functional potential.
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Marine phlorotannin Trifuhalol A coordinately regulates endothelial nitric oxide signaling and ACE activity to maintain vascular homeostasis

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00790B, Paper

Fengqi Yang, D. S. Dissanayake, Aaron Taehwan Kim, D. P. Nagahawatta, You-Jin Jeon
Trifuhalol A supports vascular homeostasis by enhancing endothelial NO signaling and modulating ACE activity within the renin–angiotensin and kallikrein–kinin pathways.
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Integrating network pharmacology and MALDI-MSI spatial metabolomics revealing ellagic acid as the key anti-pharyngitis agent in Fructus Chebulae and its key metabolic pathways in pharyngeal tissues

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05286F, Paper

Yifei Kong, Chao Wang, Ya Zhang, Xingping Luo, Fangdi Hu, Juan Chen, Xinyue Chen
Evaluation of the anti-pharyngitis efficacy of ellagic acid and investigation of its mechanism.
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Preparation and Anti-inflammatory Activity of Specific Selenium Chelated Peptides from Antarctic Krill

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00467A, Paper

Guojing Xu, Hailin Yin, Shuang Du, Zongyu Zhang, Jing Dai, Yunlong Chen, Xiqing Bian, Liangtao Lv
This study has successfully developed selenium-chelated peptides (Se-AKPs) from Antarctic krill for the treatment of inflammatory bowel disease. Antarctic krill peptides (AKPs) were prepared by alkaline protease hydrolysis and then...
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The anti-inflammatory activity of palmitoleic acid from macadamia nuts

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00826G, Paper

Wen-Hui Sun, Ya-Zhuan Li, Wen Dai, Chin-Ping Tan, Xiao-Song Rong, Yong-Jiang Xu
POA intervention may attenuate LPS-induced oxidative stress through the NRF2/TBK1/lysosomal axis, thereby alleviating inflammation.
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Protective efficacy and related mechanism of a new ADH activating peptide YRPG from Lactococcus lactis against acute alcohol-induced injury

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01977C, Paper

Anran Feng, Beijie Li, Sisi Chen, Shiyu Zhao, Zhangning Qiao, Yanling Shi, Laizheng Lu, Juanjuan Yi, Jike Lu
Excessive alcohol intake can cause severe acute alcohol injury (AAI), including gastric and liver injury. YRPG can alleviate this injury by regulating alcohol metabolism, oxidative stress, and the PI3K/AKT/FoxO3a signaling pathway.
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Lactobacillus plantarum ameliorates high-fat-diet-induced dyslipidemia via cholesterol metabolism and gut microbiota modulation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00519E, Paper

Ziyue Zhou, Yin Mao, Jinyang Li, Ju Yang, Yihui Zhang, Yunying Zhao, Yu Deng
Dyslipidemia, a typical metabolic disorder, is predominantly characterized by elevated levels of total cholesterol (TC) and/or triglycerides (TG), with disruption of cholesterol homeostasis serving as a significant contributing factor.
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Sturgeon roe protein hydrolysate alleviates cyclophosphamide-induced ovarian dysfunction in mice with reduced ovarian oxidative–inflammatory injury, granulosa cell apoptosis, and HPO axis-related endocrine imbalance

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO02422J, Paper

Silu Zhang, Hailong Li, Lijia Yang, Penglong Liu, Tingfeng Zhang, Yangyan Dai, Yuchen Pang, Shijing Ma, Mouming Zhao, Tiantian Zhao
Sturgeon roe protein hydrolysate improves CTX-induced ovarian dysfunction in association with reduced ovarian redox–inflammatory stress, granulosa cell apoptosis, and improved HPO axis-related endocrine feedback.
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Animal-based diets and the human gut microbiota: an integrative review combining metagenomic profiling and graphical synthesis of diet–microbiota associations

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00371K, Review Article

Lamia Medouni-Haroune, Sonia Medouni-Adrar, Lynda Messaoudene, Samira Negrichi, Cilia Bouiche, Yasmine Sahraoui-Remini, Ayoub Allam, Zoubeida Meghlaoui, Khokha Mouhoubi, Amina Abbou, Nassim Brahimi, Mohamed Khalil Mellal, Zoubir Sari, Khodir Madani
This review integrates metagenomic profiling of 899 human gut metagenomes with a literature-based graphical synthesis to map associations between animal-based foods and gut microbiota composition in non-diseased individuals.
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Taurine supplementation at the crossroads of metabolism, inflammation and aging: mechanistic and nutritional perspectives

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01808D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Benedikt Justus Beine, Melissa Castellano, Jarlei Fiamoncini, Karsten Hiller
Taurine, the most abundant free amino acid in mammals, supports mitochondrial function and regulates inflammation. Supplementation can improve metabolic health and promote healthy aging, highlighting its potential as a dietary modulator in nutrition.
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The hawthorn (Crataegus pinnatifida) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01304J, Paper

Xue Han, Yuchen Fang, Huanyu Wang, Anni Fu, Jianfeng Sun, Zhiqiang Wang, Lei Ma
Hawthorn procyanidin extract (HPC) is one of natural plant-derived polyphenol with lipid-lowering and liver-protective properties, while its therapeutic mechanisms against nonalcoholic fatty liver disease (NAFLD) require further clarification.
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Alleviating effects of 2′-fucosyllactose combined with Bifidobacterium longum BB536 on loperamide-induced constipation and depressive-like behavior

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00474A, Paper

Zhongmei Tan, Zihao Tian, Xiaolei Duan, He Zhang, Wei Yu, Qinggang Xie, Dong Xu, Yingying Ding, Rongbiao Ying, Jiage Ma, Qiqi Ren
This study evaluated the effects and underlying mechanism of 2′-fucosyllactose and Bifidobacterium longum BB536 on relieving loperamide-induced constipation and depressive-like behavior.
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Aged garlic extract suppressed macrophage-mediated inflammation in acute respiratory distress syndrome

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00337K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Shun Nakazawa, Shinsaku Togo, Chisato Tadokoro, Soichiro Soma, Yuta Arai, Hiroaki Motomura, Yuichi Nagata, Takuto Sueyasu, Haruki Hirakawa, Koichi Kurata, Issei Sumiyoshi, Yusuke Ochi, Junko Watanabe, Hiroaki Ihara, Kazuaki Hoshi, Motoyasu Kato, Kazuhisa Takahashi
Combining aged garlic extract (AGE) with low-dose dexamethasone broadens and enhances the suppression of pulmonary inflammation in ARDS by inhibiting NF-κB signaling, offering a potent therapeutic approach with reduced steroid side effects.
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Effects of microalgae incorporation on nutrient digestibility and antioxidant activity of gluten-free muffins after simulated chewing and digestion in adults and older adults

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01526C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Milagros Arnal, Susana Ribes, Nuria Belenguer, Pau Talens
This study evaluated the effects of microalgae incorporation, chewing conditions, and digestive models on nutrient digestibility, total phenolic content, and antioxidant activity of gluten-free muffins using in vitro boluses produced in a rheometer.
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Integrating sustainability and nutrition: comprehensive valorisation of vegetable by-products for bioactive food applications

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00309E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tatiane C De Oliveira, Tayse F.F. da Silveria, Dejan Stojkovic, Javier Cano-Lou, Gema Casado, Susana Machado, Liliana Espírito Santo, Beatriz Oliveira, Eliana Pereira, Lillian Barros
Valorising vegetable by-products is a sustainable and innovative strategy to reduce food waste and develop functional ingredients. This study investigated onion peel (Allium cepa L.), kale (Brassica oleracea L. var....
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Tibetan kefir grain-fermented milk attenuates DSS-induced colitis through coordinated regulation of intestinal barrier function, inflammation, and gut microbiota

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01565D, Paper

Ben Li, Shuai Li, Yihao Pei, Xiaojuan Sun, Chen Ding, Jin Yu, Meiling Zhou, Jianmei Han, Hong Yang, Yafan Wan
This study links the complete kefir-fermented milk matrix to colitis prevention through integrated host, microbiota, metagenomic, and metabolomic analyses.
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Apples and apple-based products in the modulation of cardiometabolic and functional markers: a systematic review of human intervention studies

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05460E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Cristian Del Bo’, Daniela Martini, Anna Giancristofaro, Marco Rendine, Mirko Marino, Maria Cristina Casiraghi, Patrizia Riso
Apple is one of the most widely consumed fruits worldwide, yet its effects on human health remain the subject of ongoing debate.
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Non-ethanol components of Baijiu alleviate ethanol-induced energy metabolism disorder and gut microbiota dysbiosis in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00947F, Paper

Yingrui Gao, Weiman Zhao, Ruonan Tong, Xiaojun Wu, Zhengtao Wang, Longchan Liu, Li Yang
Baijiu non-ethanol components restore ethanol-induced energy metabolism disorder and microbiota dysbiosis, normalize the NADH/NAD⁺ redox balance, and reduce lactate overaccumulation, thereby relieving ethanol-induced oxidative stress.
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Coordinated changes in microbiota features, short-chain fatty acids, and peripheral clocks accompany fructo-oligosaccharide–associated metabolic improvement

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO02286C, Paper

Zhenting Zhao, Junwei Zhang, Pei Du, Xinran Liu, Jin Ye, Renjie Shi, Danna Wang, Bing Xia, Xuebo Liu, Beita Zhao
Metabolic disorders induced by a high-fat diet (HFD) are closely linked to disruptions in the circadian regulation of glucose and lipid metabolism.
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Latilactobacillus sakei ZFM232 alleviates age-related lipid metabolism disorders and enhances antioxidant defense in Caenorhabditis elegans

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01144F, Paper

Gang Wang, Yubin Zhang, Fengxuan Wang, Wanting Xiao, Wan Zhou, Xiangfeng Chen, Qing Gu, Ping Li
Lactic acid bacteria (LAB) are widely recognized as beneficial microorganisms within the human microbiome; however, the mechanisms underlying their health-promoting effects remain largely elusive.
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Dietary chlorogenic acid improves lipid metabolism through modulation of the gut–liver microbiota axis in hyperlipidemic mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00434B, Paper

Abdul Basit, Abdul Mueed, Raheem Shahzad, Wang Rong, Khanizadeh Shahrokh, Adeeb Shehzad, Salman Khan, Tao Shutian
Chlorogenic acid alleviates high-fat diet-induced hyperlipidaemia and glucose dysregulation by modulating gut microbiota, remodeling metabolite networks, reducing hepatic lipid accumulation, and activating IRS1/CD36 signalling pathways.
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Inhibition of the in vitro colonic fermentation of cooked gluten by dietary fibers with individual fermentability

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00694A, Paper

Dan Yuan, Tianyi Li, Ying Li, Xingyu Tao, Zhiming Gao, Yuehan Wu, Wenxin Jiang, Yanlei Li, Xuewen Ni, Mengzhou Zhou
Alginate inhibited gluten fermentation by shielding gut microbiota from degrading gluten due to its durable fermentability. FOS inhibited gluten fermentation only for a short period of time. Cellulose even promoted gluten fermentation.
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Selenium-enriched Tibetan kefir grain-fermented goji juice attenuates patulin-induced liver injury and is associated with gut microbiota modulation in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01305H, Paper

Yifan Cheng, Jinyi Yang, Jinyue Xu, Xuejun Zeng, Kewei Feng, Yahong Yuan, Tianli Yue
Selenium-enriched Tibetan kefir grain-fermented goji juice attenuated patulin-induced liver injury by improving redox balance, reducing inflammation, and modulating gut microbiota-associated responses.
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Nut consumption as a therapeutic strategy to preserve brain function, attenuate neuropathology, and modulate cross-tissue microRNAs in a mouse model of Alzheimer's disease

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00445H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Laura Panisello, Mireia Millet-Sigalat, Nil Novau-Ferré, Javier Mateu-Fabregat, Marina Carrasco, Miren Ettcheto, Elisa Félix-Soriano, antoni camins, M. Bullo
Nutritional modulation of brain metabolism is emerging as a key strategy for preventing Alzheimer’s Disease (AD), with potential to influence key pathologies such as Aβ accumulation, tau phosphorylation, and neuroinflammation....
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Food-derived peptides for senile sarcopenia: mechanisms of action, structural characteristics, and in vivo delivery challenges

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00948D, Review Article

Manqun Wang, Wanlu Liu, Jiulong An, Xinting Luo, Janar Jenis, Xinqi Liu, He Li
Food-derived peptides (FDPs) are attracting increasing research attention for intervention in age-related sarcopenia due to their potential muscle-protective activity.
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Application of artificial intelligence in synbiotic and functional food development for precision nutrition

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00295A, Review Article

Janani B., Samuel Ayofemi Olalekan Adeyeye
Artificial Intelligence enables data-driven design of synbiotic foods by integrating multi-omics data, optimizing formulation, and predicting functional outcomes for precision nutrition.
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Folic acid enhances intestinal stem cell-mediated epithelial regeneration depending on β-adrenergic receptor signaling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01675H, Paper

Yi Zheng, Yu Han, Yuhui Zhang, Yecheng Xu, Shouchuan Jiang, Xin Wen, Xi Qiao, Yuanyuan Zhang, Yunqin Li, Huahua Du
Folic acid, a water-soluble B vitamin, is well known for its critical roles in neural tube development and its contributions to neonatal gut maturation and overall gut health.
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Plant-derived exosome-like nanoparticles ameliorate glycolipid metabolism diseases: molecular mechanism, advances and bottlenecks

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01315E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xue Li, Ran An, Hairong Wang, Shiya Yuan, Xu Shi
Glycolipid metabolism diseases, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), are increasingly becoming a significant global public health burden.
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Chlorella vulgaris as a functional food and nutraceutical: bioactive composition, health-promoting mechanisms, applications, and current challenges

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00663A, Review Article

Muhammad Abdur Rehman Shah, Fengzheng Gao, Feifei Zhu, Xinjuan Hu, Sadaf-Ilyas Kayani, Ammar AL-Farga, Sirasit Srinuanpan, Shuhao Huo
The increasing demand for sustainable and nutrient-dense food sources has intensified interest in microalgae like Chlorella vulgaris (C. vulgaris).
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Diphlorethohydroxycarmalol isolated from Ishige okamurae improves age-related muscle dysfunction by Ca2+-dependent response via the SirT1/PGC-1α pathway in vitro and in vivo

Food Funct., 2026, 17,5185-5196
DOI: 10.1039/D5FO05213K, Paper

Xueyu Wang, Chan-Young Kim, Jun-Geon Je, Yu-Jin Roh, Fengqi Yang, Hye-Won Yang, You-Jin Jeon
DPHC from brown algae Ishige okamurae stimulates the release of Ca²⁺ from the sarcoplasmic reticulum, activates the AMPK/SirT1/PGC-1α signaling pathway, and reduces ROS production, thereby resisting age-related muscle dysfunction.
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Xylitol ameliorates ASD-like behavior in Chd8+/− mice via modulations of the gut microbiome, neurotransmitters, and dendritic spine morphology

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01006G, Paper

Meng Sun, Xin Wang, Qian Zhang, Ziyi Wang, Jianhong Luo, Junyu Xu, Xiaoqiong Li
Autism spectrum disorder (ASD) is a neurodevelopmental condition with complex etiology involving gut–brain axis interactions.
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Cyanidin and delphinidin inhibit transglutaminase 2 and mitigate inflammatory effects of IFN-γ and TNF-α by molecular interaction

Food Funct., 2026, 17,4865-4879
DOI: 10.1039/D6FO00704J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Andrea Diers, Silvia Rudloff, Heike Hausmann, Anika E. Wagner, Sebastian Stricker
Enzymatic modification of gliadin peptides by calcium-dependent transglutaminase 2 (TG2) plays a central role in the pathogenesis of celiac disease (CD) and is considered a potential therapeutic target.
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Associations of dietary diversity with type 2 diabetes in two Chinese cohorts: a multi-omics study

Food Funct., 2026, 17,5142-5151
DOI: 10.1039/D6FO01294A, Paper

Boya Zhao, Yuwei Li, Siyu Li, Nuo Xu, Yuwei Shi, Yuji Yu, Weifang Zheng, Yi-Hsuan Wu, Emily Hu, Po-Kai Huang, Eunhye Lee, Chi Chang, Ying Lu, Esther M. John, Ann W. Hsing, Wei He, Shankuan Zhu
The role of overall dietary diversity in type 2 diabetes (T2D) risk remains uncertain, and the potential associations involving the gut microbiota and metabolism are poorly understood.
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Correction: Water-soluble tomato concentrate alleviates neuron apoptosis through activating ERK/CREB/BDNF signaling pathway in ischemic stroke

Food Funct., 2026, 17,5197-5197
DOI: 10.1039/D6FO90038K, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Liang Zhou, Miao Yu, Yunqi Zhang, Ruikun He, Xiao Sun, Yun Luo, Xiaobo Sun
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Oatmeal-based fiber diet outperforms resistant starch-based fiber diet in lowering serum uric acid via gut microbiota–metabolite interactions: a randomized controlled trial

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Soluble dietary fiber outperforms insoluble fiber in lowering serum uric acid: a randomized controlled trial.
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Effects of live and heat-treated Limosilactobacillus fermentum PS150 on circadian rhythms and GABAergic signaling in a caffeine-induced insomnia mouse model

Food Funct., 2026, 17,5095-5105
DOI: 10.1039/D6FO00048G, Paper

Chin-Lin Huang, Ting-Yang Hsieh, Ching-Ting Lin, Chien-Chen Wu, Ying-Chieh Tsai
PS150 and HT-PS150 may alleviate caffeine-induced sleep disturbances by modulating circadian signaling, GABAergic neurotransmission, and gut microbiota.
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Digestion characteristics of yeast protein and identification of bioactive peptides with cytoprotective effects against LPS-induced injury in C2C12 myoblasts

Food Funct., 2026, 17,5152-5169
DOI: 10.1039/D6FO01092J, Paper

Xin Cao, Hongjuan Liu, Miao Yang, Zhixian Chen, Qian Cheng, Jialin Sun, Xudong Wu, Yan Zhang, Liping Hao
Yeast protein (YP) exhibited sustained amino acid release during INFOGEST digestion and generated diverse bioactive peptides. Selected peptides showed potential bioactivity and alleviated LPS-induced injury in C2C12 myoblasts.
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(Poly)phenol profiles of plant-based diets assessed through dietary intake and urinary biomarkers

Food Funct., 2026, 17,5047-5063
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Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

E. Casas-Albertos, N. M. Rodriguez-Martín, A. Alcalá-Santiago, M. Reina-Borrego, P. Keski-Rahkonen, J. Marchiandi, B. Sarriá, E. Ruiz-Moreno, C. Piernas, M. D. Ruiz-López, B. García-Villanova, E. J. Guerra-Hernández, A. Castelló-Pastor, R. Zamora-Ros, E. Molina-Montes
(Poly)phenol profiles of plant-based diets assessed through dietary intake and urinary biomarkers in the OMIVECA study.
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Evaluation of in vitro fermentation characteristics and tolerance of lactose-free milk powder for lactose intolerant subjects

Food Funct., 2026, 17,5170-5184
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Sisi Xiong, Weixin Xu, Jiale Si, Yanlong Wen, Wenyi Zhang, Sufang Duan, Ziyi Wang, Jia Li, Yadong Zhong, Lian Yang, Yanyan Zhao, Yuqin Xi, Dongyue Ouyang, Yang Liu, Zhijian He, Tianle Feng, Yuanyuan Tang, Jian He, Ming Li, Jielun Hu
The global prevalence of lactose malabsorption (LM) ranges from 65% to 70%, even reaching 100% in some Asian regions, while that of lactose intolerance (LI) remains unclear due to diagnostic complexity.
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