RSC - Integr. Biol. latest articles

Emerging methodologies to investigate lipid-protein interactions

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00143H, Critical Review

Jordan L. Scott, Catherine A. Musselman, Emmanuel Adu-Gyamfi, Tatiana G. Kutateladze, Robert V. Stahelin
Coincidence detectors such as the PX domain of p47^phox are able to coordinate two distinct lipids to modulate their cellular localization and activation.
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A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00148A, Perspective

Penney M. Gilbert, Stephane Corbel, Regis Doyonnas, Karen Havenstrite, Klas E. G. Magnusson, Helen M. Blau
Single cell studies reveal the potent regulation of muscle stem cell self-renewal by substrate stiffness.
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Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00175F, Technical Innovation

Juliane Liepe, Harriet Taylor, Chris P. Barnes, Maxime Huvet, Laurence Bugeon, Thomas Thorne, Jonathan R. Lamb, Margaret J. Dallman, Michael P. H. Stumpf
We present a statistical framework to calibrate spatio-temporal models of leukocyte migration during acute injury to live imaging data.
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Statistical platform to discern spatial and temporal coordination of endothelial sprouting

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00057A, Paper

William W. Yuen, Nan R. Du, Dima Shvartsman, Praveen R. Arany, Henry Lam, David J. Mooney
We present the integration of an in vitro angiogenesis platform, quantitative imaging processing algorithm, and statistical models to investigate the temporal synchronization of endothelial sprouts.
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On the trail of EHEC/EAEC-unraveling the gene regulatory networks of human pathogenic Escherichia coli bacteria

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00132B, Paper

Josch Pauling, Richard Rottger, Andreas Neuner, Heladia Salgado, Julio Collado-Vides, Prabhav Kalaghatgi, Vasco Azevedo, Andreas Tauch, Alfred Puhler, Jan Baumbach
An online platform for identifying potential transcriptional regulators of pathogenic EHEC/EAEC genes utilizing evolutionary conservation of transcriptional regulatory systems between E. coli K-12 and 16 human pathogenic EHEC/EAEC strains.
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Epithelial cell guidance by self-generated EGF gradients

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00106C, Paper

Cally Scherber, Alexander J. Aranyosi, Birte Kulemann, Sarah P. Thayer, Mehmet Toner, Othon Iliopoulos, Daniel Irimia
A self-guidance strategy enables normal and malignant epithelial cells to migrate persistently towards spaces with fewer cells, along the shortest path, by balancing the rate of epidermal growth factor (EGF) uptake, the restricted EGF diffusive transport through the surrounding microenvironment, and the chemotaxis towards the resulting EGF gradients.
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High-throughput clonal analysis of neural stem cells in microarrayed artificial niches

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00070A, Paper

Marta Roccio, Samy Gobaa, Matthias P. Lutolf
High-throughput clonal analysis of neural stem cell fate in microarrayed artificial niches.
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Combinatorial cell-3D biomaterials cytocompatibility screening for tissue engineering using bioinspired superhydrophobic substrates

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00170E, Technical Innovation

Christiane L. Salgado, Mariana B. Oliveira, Joao F. Mano
A flat bioinspired platform based on wettability differences of treated superhydrophobic polystyrene is proposed for the high-throughput study of combinatorial cell-3D hydrogels interactions.
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MudPIT analysis of released proteins in Pseudomonas aeruginosa laboratory and clinical strains in relation to pro-inflammatory effects

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00127F, Paper

Gabriella Bergamini, Dario Di Silvestre, Pierluigi Mauri, Cristina Cigana, Alessandra Bragonzi, Antonella De Palma, Louise Benazzi, Gerd Doring, Baroukh Maurice Assael, Paola Melotti, Claudio Sorio
In this work we applied a MudPIT approach combined with cell biology assays to identify putative virulence factors released by clinically relevant Pseudomonas aeruginosa strains.
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CdTe/CdSe quantum dots improve the binding affinities between [small alpha]-amylase and polyphenols

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00152G, Paper

Xiaoling Ni
CdTe/CdSe quantum dots enhance the affinities of polyphenols for [small alpha]-amylase.
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Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00120A, Paper

Ekaterina Kniazeva, John W. Weidling, Rahul Singh, Elliot L. Botvinick, Michelle A. Digman, Enrico Gratton, Andrew J. Putnam
To better understand the reciprocal and dynamic nature of the cell-ECM interface and its effects on capillary morphogenesis, we have employed two relatively sophisticated physics-based methods, STICS and AMR.
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The plant cell uses carbon nanotubes to build tracheary elements

Integr. Biol., 2012, 4,127-131
DOI: 10.1039/C2IB00135G, Paper

Maged F. Serag, Noritada Kaji, Manabu Tokeshi, Alberto Bianco, Yoshinobu Baba
Arabidopsis cells deposit internalized carbon nanotubes (red luminescence) into the lignified walls (green luminescence) of trans-differentiated tracheary cells.
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A progressive approach on zebrafish toward sensitive evaluation of nanoparticles' toxicity

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00130F, Paper

Yang Liu, Bin Liu, Daofu Feng, Chunying Gao, Ming Wu, Ningning He, Xinlin Yang, Lei Li, Xizeng Feng
A progressive approach was put forward to assess the toxicity of nanoparticles sensitively by analyzing the malformation speeds of zebrafish.
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One-step purification of functional human and rat pancreatic alpha cells

Integr. Biol., 2012, 4,209-219
DOI: 10.1039/C2IB00125J, Technical Innovation

Martin Kohler, Elisabetta Dare, Muhammed Yusuf Ali, Subu Surendran Rajasekaran, Tilo Moede, Barbara Leibiger, Ingo B. Leibiger, Annika Tibell, Lisa Juntti-Berggren, Per-Olof Berggren
Novel one-step sorting protocols for separating highly pure and functional human and rat alpha cells using intrinsic cellular properties.
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Quantifying cellular differentiation by physical phenotype using digital holographic microscopy

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00129B, Paper

Kevin J. Chalut, Andrew E. Ekpenyong, Warren L. Clegg, Isabel C. Melhuish, Jochen Guck
Physical changes in differentiating cells-made so they can migrate or squeeze through gaps as necessary-are occurring at a system level; thus they can be observed with marker-free biophotonics. In this work, we measure how biophotonics can be used to quantitatively assess cellular differentiation in a marker-free, non-destructive manner.
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Cell cycle synchronization by nutrient modulation

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00083K, Technical Innovation

Yuan Tian, Chunxiong Luo, Yuheng Lu, Chao Tang, Qi Ouyang
A technical innovation which can be exploited to study the coupling between cell division and metabolism or synchronize the cell cycle.
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