RSC - Integr. Biol. latest articles

Selectin-mediated adhesion in shear flow using micropatterned substrates: multiple-bond interactions govern the critical length for cell binding

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB20036H, Paper

ZiQiu Tong, Luthur Siu-Lun Cheung, Kathleen J. Stebe, Konstantinos Konstantopoulos
Using an integrated experimental/mathematical approach, we demonstrate that the critical length for cell tethering is dictated by the minimum number of required receptor-ligand bonds and their individual tensile strength.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00165A, Paper

Melissa A. Kinney, Rabbia Saeed, Todd C. McDevitt
Uniform populations of embryoid bodies were formed using micro-wells prior to culture in mixed suspension, to interrogate the morphological and phenotypic responses of embryonic stem cells to hydrodynamic environments.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanism of a flow-gated angiogenesis switch: Early signaling events at cell-matrix and cell-cell junctions

Integr. Biol., 2012, Accepted Manuscript
DOI: 10.1039/C2IB00184E, Paper

Vernella Vickerman, Roger Kamm
A bias towards angiogenesis from the venous circulation has long been known, but its cause remains unclear. Here we explore the possibility that high interstitial pressure in tumors and the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis

Integr. Biol., 2012, Accepted Manuscript
DOI: 10.1039/C2IB20061A, Paper

Jonathan W. Song, Despina Bazou, Lance Munn
Here we describe a microfluidic device that accurately reproduces the dynamics of vascular anastomosis, the process by which vascular sprouts connect to achieve perfusion during angiogenesis. The micro-device features two...
The content of this RSS Feed (c) The Royal Society of Chemistry

A high-throughput imaging system to quantitatively analyze the growth dynamics of plant seedlings

Integr. Biol., 2012, Accepted Manuscript
DOI: 10.1039/C2IB20020A, Technical Innovation

Yongfan Men, Qiang Yu, Zitian Chen, Jianbin Wang, Yanyi Huang, Hongwei Guo
Most current methods for analyzing the growth rate of plant seedlings are limited to low-throughput experimental configurations. We have developed an automatic system to investigate the dynamics of the growth...
The content of this RSS Feed (c) The Royal Society of Chemistry

Monitoring of the prostate tumour cells redox state and real-time proliferation by novel biophysical techniques and fluorescent staining

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00157H, Paper

Michal Masarik, Jaromir Gumulec, Marian Hlavna, Marketa Sztalmachova, Petr Babula, Martina Raudenska, Monika Pavkova-Goldbergova, Natalia Cernei, Jiri Sochor, Ondrej Zitka, Branislav Ruttkay-Nedecky, Sona Krizkova, Vojtech Adam, Rene Kizek
The present paper is focused on zinc(II) treatment effects on prostatic cell lines PC-3 (tumour) and PNT1A (non-tumour).
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Encapsulation of angiogenic monocytes using bio-spraying technology

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB20033C, Paper

Ashish S. Patel, Alberto Smith, Rizwan Q. Attia, Katherine Mattock, Julia Humphries, Oliver Lyons, Prakash Saha, Bijan Modarai, Suwan N. Jayasinghe
Human monocytes were encapsulated using novel bio-spraying technology and their angiogenic potential was assessed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Breast tumor initiating cell fate regulated by microenvironmental cues from extracellular matrix

Integr. Biol., 2012, Accepted Manuscript
DOI: 10.1039/C2IB20034A, Paper

sharmistha saha, Pang-Kuo Lo, xinrui duan, Hexin Chen, Qian Wang
Cancer Stem Cells also known as tumour-initiating cells (TICs) are identified as highly tumourigenic population within tumours and hypothesized to be main regulators in tumour growth, metastasis and relapse. Evidence...
The content of this RSS Feed (c) The Royal Society of Chemistry

Chromatin accessibility at the HIV LTR promoter sets a threshold for NF-[small kappa]B mediated viral gene expression

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB20009K, Paper

Kathryn Miller-Jensen, Siddharth S. Dey, Nhung Pham, Jonathan E. Foley, Adam P. Arkin, David V. Schaffer
The chromatin environment at integrated HIV-1 LTR promoters sets a gene expression induction threshold in response to NF-[small kappa]B RelA.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Spatiotemporal coordinated hierarchical properties of cellular protrusion revealed by multiscale analysis

Integr. Biol., 2012, Accepted Manuscript
DOI: 10.1039/C2IB20013A, Paper

Hiromi Miyoshi, Taiji Adachi
We present a methodology for integrative multiscale analysis to highlight hierarchical properties and mechanochemical interactions in cellular protrusion based on live cell imaging data with high spatiotemporal resolution. As an...
The content of this RSS Feed (c) The Royal Society of Chemistry

Role of regucalcin in brain calcium signaling: Involvement in aging

Integr. Biol., 2012, Accepted Manuscript
DOI: 10.1039/C2IB20042B, Review Article

Masayoshi Yamaguchi
Regucalcin was discovered in 1978 as a calcium-binding protein that does not contain EF-hand motif of calcium-binding domain [Yamaguchi M and Yamamoto T, Chem Pharm Bull, 26: 1915-1918, 1978]. The...
The content of this RSS Feed (c) The Royal Society of Chemistry

RhoA-induced cytoskeletal tension controls adaptive cellular remodeling to mechanical signaling

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB20008B, Paper

Soon-Mi Lim, Jerome P. Trzeciakowski, Harini Sreenivasappa, Lawrence J. Dangott, Andreea Trache
Cells sense and adapt to microenvironmental mechanical signaling by a coordinated response of the actomyosin apparatus which is modulated by the pre-existing cytoskeletal tension.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Diacylglycerol kinase zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB00002D, Paper

Dooyoung Lee, Jiyeon Kim, Michael T. Beste, Gary A. Koretzky, Daniel A. Hammer
We performed computer simulations of the adhesion of T cells on surfaces under flow, with and without the key intracellular enzyme diacylglycerol kinase [small zeta] (DGK[small zeta]) Predictions show deletion of DGK[small zeta] leads to a gain of adhesion which confirmed by experiment.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Resolving brain regions using nanostructure initiator mass spectrometry imaging of phospholipids

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB20043K, Technical Innovation

Do Yup Lee, Virginia Platt, Ben Bowen, Katherine Louie, Christie A. Canaria, Cynthia T. McMurray, Trent Northen
Nanostructure-initiator mass spectrometry based imaging coupled to multivariate statistical analysis is used to determine region-specific, unique molecular identities that discriminate brain regions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Preparation, characterization, and surface immobilization of native vesicles obtained by mechanical extrusion of mammalian cells

Integr. Biol., 2012, Advance Article
DOI: 10.1039/C2IB20022H, Technical Innovation

Huawen Wu, Ann E. Oliver, Viviane N. Ngassam, Chanel K. Yee, Atul N. Parikh, Yin Yeh
Simple mechanical extrusion of whole mammalian cells produces microscopic vesicularized particles enriched in selected plasma membrane components that preserve their local micro-environments and functions, with demonstrated surface immobilization and patternability.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry