RSC - Lab Chip latest articles

New ' one-step ' method for the simultaneous synthesis and anchoring of organic monolith inside COC microchip channel

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21211K, Paper

Yoann Ladner, Anthony Bruchet, Gerard Cretier, Vincent Dugas, Jerome Randon, Karine Faure
A new method for monolith synthesis and anchoring inside cyclic olefin copolymer (COC) microchannels in a single step is proposed. It is shown that type I photoinitiators, typically used in...
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A Portable and Integrated Nucleic Acid Amplification Microfluidic Chip for Identifying Bacteria

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40055C, Communication

Xueen Fang, Jilie Kong
In this work, we developed a portable integrated microchip of loop-mediated isothermal nucleic acid amplification (LAMP). This chip with sample-to-answer capability could perform rapid DNA extraction, exponential signal amplification and...
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Controlled Generation of Submicron Emulsion Droplets via Highly Stable Tip-streaming Mode in Microfluidic Devices

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC00018K, Paper

Woong-Chan Jeong, Jong-Min Lim, Jae-Hoon Choi, Jong Hun Kim, Yu-Jin Lee, Seung-Hyun Kim, Gaehang Lee, Jong-Duk Kim, Gi-Ra Yi, Seung-Man Yang
Submicron emulsions could be produced via the tip-streaming process in a flow-focusing microfluidic device. In this article, the stability of liquid cone and thread for tip-streaming mode could be significantly...
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Microfluidic Magnetophoretic Separations of Immunomagnetically Labeled Rare Mammalian Cells

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40113D, Paper

Thomas P Forbes, Samuel P Forry
Immunomagnetic isolation and magnetophoresis in microfluidics have emerged as viable techniques for the separation, fractionation, and enrichment of rare cells. Here, we present the development and characterization of a microfluidic...
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Nebulisation on a disposable array structured with phononic lattices

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20705B, Paper

Julien Reboud, Rab Wilson, Yi Zhang, Mohd H. Ismail, Yannyk Bourquin, Jonathan M. Cooper
Phononic lattices on a disposable chip shape the acoustic field and selectively nebulise liquid drops in an array.
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Cell sorting by deterministic cell rolling

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21225K, Communication

Sungyoung Choi, Jeffrey M. Karp, Rohit Karnik
This paper presents the concept of "deterministic cell rolling", a new label-free, single-step, bioaffinity-based separation that combines transient cell-surface molecular interactions with passive hydrodynamic control to separate cells in a continuous process without requiring separate capture and elution steps.
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Sorting cells by size, shape and deformability

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21083E, Communication

Jason P. Beech, Stefan H. Holm, Karl Adolfsson, Jonas O. Tegenfeldt
While size has been widely used as a parameter in cellular separations, in this communication we show how shape and deformability, a mainly untapped source of specificity in preparative and analytical microfluidic devices can be measured and used to separate cells.
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The application of an optically switched dielectrophoretic (ODEP) force for the manipulation and assembly of cell-encapsulating alginate microbeads in a microfluidic perfusion cell culture system for bottom-up tissue engineering

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21097E, Paper

Yen-Heng Lin, Ya-Wen Yang, Yi-Dao Chen, Shih-Siou Wang, Yu-Han Chang, Min-Hsien Wu
The application of an optically switched dielectrophoretic (ODEP) force in a microfluidic perfusion cell culture system for bottom-up tissue engineering.
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Microfluidic biomechanical assay for red blood cells parasitized by Plasmodium falciparum

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20857A, Paper

Quan Guo, Sarah J. Reiling, Petra Rohrbach, Hongshen Ma
We present a microfluidic device for measuring the deformability of red blood cells parasitized by Plasmodium falciparum, the most prevalent species of parasites that cause malaria. Parasitized cells from ring to schizont stages were shown to be 1.5 to 200 times stiffer than uninfected cells, with clearly distinguishable deformability distributions over their respective populations.
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Droplet microfluidics for high-throughput biological assays

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21147E, Critical Review

Mira T. Guo, Assaf Rotem, John A. Heyman, David A. Weitz
Droplet microfluidics enables new high-throughput screening applications by using picolitre volumes, kilohertz manipulation and measurement speeds, and high effective concentrations.
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A microfluidic device for high throughput bacterial biofilm studies

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20800H, Paper

Jeongyun Kim, Manjunath Hegde, Sun Ho Kim, Thomas K. Wood, Arul Jayaraman
We describe the development of a microfluidic flow cell ([small mu ]FC) device for investigating bacterial biofilm formation in response to different concentrations of soluble signals, either individually or in combination.
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Application of click chemistry to the production of DNA microarrays

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21096G, Paper

Barbara Uszczynska, Tomasz Ratajczak, Emilia Frydrych, Hieronim Maciejewski, Marek Figlerowicz, Wojciech T. Markiewicz, Marcin K. Chmielewski
The CuAAC reaction was applied as the novel method of DNA immobilization on a modified solid support. The click reaction enables the covalent binding of DNA modified with pentynyl groups at its 50-end to azide-loaded slides.
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Gene-Z: A Device for Point of Care Genetic Testing using a Smartphone

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21226A, Paper

Robert Donald Stedtfeld, Dieter Tourlousse, Gregoire Seyrig, Tiffany Stedtfeld, Maggie Kronlein, Scott Price, Farhan Ahmad, Gulari Erdogan, James Tiedje, Syed Hashsham
By 2012, point of care (POC) testing will constitute roughly one third of the $59 billion in vitro diagnostics market. The ability to carry out multiplexed genetic testing and wireless...
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Rapid screening of antibiotic toxicity in an automated microdroplet system

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21284F, Paper

Krzysztof Churski, Tomasz S Kaminski, Slawomir Jakiela, Wojciech Kamysz, Wioletta Baranska-Rybak, Douglas Weibel, Piotr Garstecki
We report an automated microfluidic platform for 'digitally' screening the composition space of droplets containing cocktails of small molecules and demonstrate the features of this system by studying epistatic interactions...
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A low-cost 2D fluorescence detection system for [small micro]m-sized beads on-chip

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21187D, Technical Innovation

Loes Segerink
In this paper we describe a compact fluorescence detection system for on-chip analysis of beads, comprising a low-cost optical HD-DVD pickup. The complete system consists of a fluorescence detection unit,...
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Three-Dimensional Microfiber Devices that Mimic Physiological Environments to Probe Cell Mechanics and Signaling

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21117C, Technical Innovation

Warren Christopher Ruder, Erica D Pratt, Sasha Bakhru, Metin Sitti, Stefan Zappe, James Antaki , Philip R LeDuc
Many physiological systems are regulated by cells that alter their behavior in response to changes in their biochemical and mechanical environment. These cells experience this dynamic environment through an endogenous...
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Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21145A, Paper

Melissa Li
Thrombosis is the pathological formation of platelet aggregates which occlude blood flow causing stroke and heart attack-the leading causes of death in developed nations. Instrumentation for diagnosing and exploring treatments...
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Digital LAMP in a sample self-digitization (SD) chip

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21247A, Paper

Alexander Gansen, Alison Herrick, Ivan Krastev Dimov, Luke Lee, Daniel T Chiu
This paper describes the realization of digital loop-mediated DNA amplification (dLAMP) in a sample self-digitization (SD) chip. Digital DNA amplification has become an attractive technique to quantify absolute concentrations of...
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Engineers are from PDMS-land, Biologists are from Polystyrenia

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20982A, Critical Review

Erwin Berthier, Edmond W. K. Young, David Beebe
We review the use of PDMS and polystyrene in cell-based microfluidics to provide insight into the central issue of material selection in the emerging interdisciplinary field of bio-microfluidics.
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Single particle analysis using fluidic, optical and electrophoretic force balance in a microfluidic system

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21017G, Paper

Qin Lu, Alex Terray, Greg E. Collins, Sean J. Hart
A unique microfluidic system is developed which enables the interrogation of a single particle by using multiple force balances from a combination of optical force, hydrodynamic drag force, and electrophoretic force.
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Integrated three-dimensional filter separates nanoscale from microscale elements in a microfluidic chip

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21116E, Paper

Lorenzo Amato, Yu Gu, Nicola Bellini, Shane M. Eaton, Giulio Cerullo, Roberto Osellame
Integration of a size-based three-dimensional filter, with micrometre-sized pores, in an already sealed commercial microfluidic chip by two-photon polymerization.
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High sensitivity three-dimensional insulator-based dielectrophoresis

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21212A, Paper

William A. Braff, Alexandre Pignier, Cullen R. Buie
A novel device utilizing three dimensional insulator based dielectrophoresis promotes low voltage particle and cell trapping with minimal Joule heating.
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Progress toward multiplexed sample-to-result detection in low resource settings using microfluidic immunoassay cards

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20751F, Paper

Lisa Lafleur, Dean Stevens, Katherine McKenzie, Sujatha Ramachandran, Paolo Spicar-Mihalic, Mitra Singhal, Amit Arjyal, Jennifer Osborn, Peter Kauffman, Paul Yager, Barry Lutz
We describe a platform that detects disease-specific antigens and IgM antibodies. The disposable microfluidic cards are based on a flow-through membrane immunoassay carried out on porous nitrocellulose.
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Hydrodynamic shearing of DNA in a polymeric microfluidic device

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21122J, Communication

Irina V. Nesterova, Mateusz L. Hupert, Malgorzata A. Witek, Steven A. Soper
We report a polymer-based microfluidic device that establishes an efficient and inexpensive platform with performance comparable to a commercially available bench-top system.
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Mechanical disruption of mammalian cells in a microfluidic system and its numerical analysis based on computational fluid dynamics

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20918G, Paper

Matthias Wurm, An-Ping Zeng
We devised a mechanical approach to obtain a quick and reagentless disruption of mammalian cells and developed a mathematical model to predict cell disruption in microfluidic systems based on CFD-analysis.
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Spinning magnetic trap for automated microfluidic assay systems

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21189K, Paper

Jasenka M. Verbarg, Kian Kamgar-Parsi, Adam R. Shields, Peter Howell, Frances Ligler
While sophisticated assays have been developed and analyzed using lab-on-chip devices, in most cases the sample preparation is still performed off chip. The global need for easy-to-use, disposable testing devices...
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Oil-sealed femtoliter fiber-optic arrays for single molecule analysis

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21113K, Paper

Huaibin Zhang, Shuai Nie, Candice M. Etson, Raymond M. Wang, David R. Walt
We present a method for sealing high-density arrays of femtoliter-sized aqueous reaction chambers with a droplet of oil.
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Droplet-based interfacial capacitive sensing

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21168H, Paper

Baoqing Nie, Siyuan Xing, James D. Brandt, Tingrui Pan
We presented a novel droplet-based pressure sensing device, utilizing an elastic electrolyte-electrode contact with large interfacial capacitance, to achieve ultrahigh sensitivity (1.58 [small mu ]F kPa^-1) and resolution (1.8 Pa) with flexible and transparent constructs.
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A Three-Dimensional Microvascular Gas Exchange Unit for Carbon Dioxide Capture

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC00033D, Technical Innovation

Du Thai Nguyen, Y T. Leho, Aaron Palmer Esser-Kahn
For the capture of CO2 from mixed gas streams, materials for increased gas exchange are necessary. Efficient gas exchange systems already exist in the form of vascularized lung-tissue. Herein we...
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Integration of Field effect Transistor-Based Biosensors with Digital Microfluidic Device for a Lab-on-a-chip Application

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21203J, Paper

Kyungyong Choi, Jee-Yeon Kim, Jae-Hyuk Ahn, Ji-Min Choi, Maesoon Im, Yang-Kyu Choi
A new platform for lab-on-a-chip system is suggested that utilizes a biosensor array embedded in a digital microfluidic device. With field-effect transistor (FET)-based biosensors embedded in the middle of droplet-driving...
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Miniaturised technologies for the development of artificial lipid bilayer systems

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20991H, Critical Review

Michele Zagnoni
The development of artificial cell membrane microsystems is reviewed, discussing advantages and limitations of classic and unconventional approaches.
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Design considerations for electrostatic microvalves with applications in poly(dimethylsiloxane)-based microfluidics

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21133E, Paper

Amit V. Desai, Joshua D. Tice, Christopher A. Apblett, Paul J. A. Kenis
We present an analytical model to guide the design of electrostatic microvalves that can be integrated into microfluidic chips using standard fabrication processes and can reliably operate at low actuation potentials (<250 V).
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Acoustofluidics 6: Experimental characterization of ultrasonic particle manipulation devices

Lab Chip, 2012, 12,852-862
DOI: 10.1039/C2LC21067C, Focus

Jurg Dual, Philipp Hahn, Ivo Leibacher, Dirk Moller, Thomas Schwarz
This acoustofluidics tutorial describes different measurement techniques used for the experimental characterization of ultrasonic particle manipulation devices.
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Enhanced discrimination of DNA molecules in nanofluidic channels through multiple measurements

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20771K, Paper

Yi-Heng Sen, Tarun Jain, Carlos A. Aguilar, Rohit Karnik
Multiple measurements on the same DNA molecule translocating through a nanochannel enable enhanced discrimination between molecules of different lengths.
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Research highlights

Lab Chip, 2012, 12,849-851
DOI: 10.1039/C2LC90011D, Highlight

Seila Selimovic, Ali Khademhosseini
Self-similar topographies on shrink-film for cell culture - Optically adjustable, dynamic microfluidic chips - Protein profiling with microgels
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Standards for connecting microfluidic devices?

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20937C, Focus

Henne van Heeren
There is much diversity in microfluidics, but serious work on development of standards is being done by several groups, and the first results become visible. This will undoubtedly have a large impact on all working in this field.
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Microfluidic nanoplasmonic-enabled device for multiplex DNA detection

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21114A, Paper

Hsin-I Peng, Christopher M. Strohsahl, Benjamin L. Miller
Uniform coating of Ag nanoparticles leads to a rapid, arrayble and self-labelled microfluidic device able to detect DNA in real time.
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Rational aspect ratio and suitable antibody coverage of gold nanorod for ultra-sensitive detection of a cancer biomarker

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20588B, Paper

Phuoc Long Truong, Byung Woo Kim, Sang Jun Sim
By experimentally determining the optimal sensitivity of Au nanorods for an individual optical nanosensor and optimizing the accessibility between the carboxyl groups of the self-assembled monolayer on the gold nanorod surface and the PSA mAb, the individual Au nanorod sensor was effectively exploited for the detection of a PSA biomarker with 1 aM sensitivity ([similar]6 [times] 10⁵ molecules).
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A vertically aligned carbon nanotube-based impedance sensing biosensor for rapid and high sensitive detection of cancer cells

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21028B, Paper

Mohammad Abdolahad, Mohammad Taghinejad, Hossein Taghinejad, Mohsen Janmaleki, Shams Mohajerzadeh
Great mechanical and electrical interactions between cancer cells and carbon nanotubes were applied for a new cancer cell impedance biosensor.
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A parallel diffusion-based microfluidic device for bacterial chemotaxis analysis

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21219F, Paper

Guangwei Si, Wei Yang, Shuangyu Bi, Chunxiong Luo, Qi Ouyang
We developed a multiple-channel microfluidic device for bacterial chemotaxis detection. Some characters such as easy operation, parallel sample adding design and fast result readout make this device convenient for most...
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On-bead expression of recombinant proteins in an agarose gel matrix coated on a glass slide

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21239K, Paper

Kyung-Ho Lee, Ka-Young Lee, Ju-Young Byun, Byung-Gee Kim, Dong-Myung Kim
A system for expression and in situ display of recombinant proteins on microbead surface is described. Biotinylated PCR products were immobilized on microbead surfaces, which were then embedded in a...
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Field-portable wide-field microscopy of dense samples using multi-height pixel super-resolution based lensfree imaging

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21072J, Communication

Alon Greenbaum, Uzair Sikora, Aydogan Ozcan
We report a field-portable lensfree microscope that can image dense and connected specimens with sub-micron resolution over a large field-of-view of ~30 mm2 (i.e., ~6.4 mm x ~4.6 mm) using...
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Interfacial Organic Synthesis in a Simple Droplet-Based Microfluidic System

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40052A, Paper

Pengyuan Yang, Ji Ji, Liping Guo, Yiqing Zhao, Chang Ji, Baohong Liu
A spherical liquid-liquid interface can be obtained by dispersing one liquid phase into the other to form droplets, which will facilitate the two-phase reactions between the immiscible participating fluids. The...
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A facile in situ microfluidic method for creating multivalent surfaces: Toward functional glycomics

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21217J, Paper

Giuseppina Simone
An in situ method of modifying the chemistry and topology of microfluidic surfaces in order to mimic in vivo cellular mechanisms is described. The binding of functionalised microbeads to microfluidic...
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Bulk- and Surface-Modified Combinable PDMS Capillary Sensor Array as Easy-to-Use Sensing Device with Enhanced Sensitivity to Elevated Concentrations of Multiple Serum Sample Components

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21242K, Paper

Yuji Fujii, Terence G Henares, Kunio Kawamura, Tatsuro Endo, Hideaki Hisamoto
To enhance sensitivity and facilitate easy sample introduction into a combinable poly(dimethylsiloxane) (PDMS) capillary (CPC) sensor array, bulk and surface modifications of PDMS were conducted to prepare "black" PDMS covered...
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Immunosensor towards Low-Cost, Rapid Diagnosis of Tuberculosis

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21131A, Technical Innovation

Jong-Hoon Kim, Woon-Hong Yeo, Zhiquan Shu, Scott D Soelberg, Shinnoske Inoue, Dinesh Kalyanasundaram, John Ludwig, Clement E Furlong, James J Riley, Kris Weigel, Gerard A Cangelosi, Kieseok Oh, Kyong-Hoon Lee, Dayong Gao, Jae-Hyun Chung
A long-sought goal for tuberculosis diagnosis is a rapid, accurate tool that is compatible with the needs of tuberculosis-endemic settings. An immunofluorescence microtip sensor is described that detects Mycobacterium tuberculosis...
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Commercialization of microfluidic point-of-care diagnostic devices

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21204H, Critical Review

Curtis David Chin, Vincent Linder, Samuel K Sia
A large part of the excitement behind microfluidics is in its potential for producing practical devices, but surprisingly few lab-on-a-chip based technologies have been successfully introduced into the market. Here,...
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Rapid microarray processing using a disposable hybridization chamber with an integrated micropump

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21110F, Paper

Jochen Rupp
We present a disposable microarray hybridization chamber with an integrated micropump to speed up diffusion based reaction kinetics by generating convective flow. The time-to-result for the hybridization reaction was reduced...
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Multi-focal multiphoton lithography

Lab Chip, 2012, 12,867-871
DOI: 10.1039/C2LC21271D, Technical Innovation

Eric T. Ritschdorff, Rex Nielson, Jason B. Shear
Scanning a dynamic mask with multiple laser foci provides parallelism for multiphoton lithography of large-scale microstructures.
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Dual-electrode microfluidic cell for characterizing electrocatalysts

Lab Chip, 2012, 12,986-993
DOI: 10.1039/C2LC21181E, Paper

Ioana Dumitrescu, David F. Yancey, Richard M. Crooks
We describe a dual-electrode microelectrochemical device suitable for characterising electrocatalysts.
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DNA molecules descending a nanofluidic staircase by entropophoresis

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21152A, Paper

Samuel M. Stavis, Jon Geist, Michael Gaitan, Laurie E. Locascio, Elizabeth A. Strychalski
Complex nanofluidic confinement established a free energy landscape that enabled passive control over the transport and concentration of DNA molecules.
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A completely in vitro ultrahigh-throughput droplet-based microfluidic screening system for protein engineering and directed evolution

Lab Chip, 2012, 12,882-891
DOI: 10.1039/C2LC21035E, Paper

Ali Fallah-Araghi, Jean-Christophe Baret, Michael Ryckelynck, Andrew D. Griffiths
A microfluidic system in which droplets containing in vitro translated enzymes are screened at up to 2000 droplets per second.
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An on-chip whole blood/plasma separator using hetero-packed beads at the inlet of a microchannel

Lab Chip, 2012, 12,863-866
DOI: 10.1039/C2LC21009F, Technical Innovation

Joon S. Shim, Chong H. Ahn
An integrated microfilter has been simply implemented at the inlet of a microchannel using hetero-packed beads and applied to realize the on-chip stationary blood/plasma separator.
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Label-free detection of a bacterial pathogen using an immobilized siderophore, deferoxamine

Lab Chip, 2012, 12,971-976
DOI: 10.1039/C2LC20904G, Paper

Youngsoon Kim, David P. Lyvers, Alexander Wei, Ronald G. Reifenberger, Philip S. Low
We present a novel pathogen recognition methodology that involves capture of the desired pathogen by its cognate siderophore onto a chip.
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Simple method to fabricate electrochemical sensor systems with predictable high-redox cycling amplification

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21233A, Paper

Martin Straver, Mathieu Odijk, Wouter Olthuis, Albert van den Berg
In this paper an easy to fabricate SU8/glass-based microfluidic sensor is described with two closely spaced parallel electrodes for highly selective measurements using the redox cycling effect. By varying the...
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Continuous Separation of Microparticles in a Microfluidic Channel via the Elasto-inertial Effect of Non-Newtonian Fluid

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21304D, Paper

Jeonghun Nam, HyunJung Lim, Dookon Kim, Hyun Wook Jung, Sehyun Shin
Pure separation and sorting of microparticles from complex fluids are essential for biochemical analyses and clinical diagnostics. However, conventional techniques require highly complex and expensive labeling processes for high purity...
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A 3D mammalian cell separator biochip

Lab Chip, 2012, 12,948-953
DOI: 10.1039/C2LC20939J, Paper

Debaditya Choudhury, William T. Ramsay, Robert Kiss, Nicholas A. Willoughby, Lynn Paterson, Ajoy K. Kar
An integrated multichannel microfluidic cell separation device enabled using ultrafast laser inscription and selective chemical etching.
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Increasing the detection speed of an all-electronic real-time biosensor

Lab Chip, 2012, 12,954-959
DOI: 10.1039/C2LC21020G, Paper

Matthew R. Leyden, Robert J. Messinger, Canan Schuman, Tal Sharf, Vincent T. Remcho, Todd M. Squires, Ethan D. Minot
We quantify the rate that proteins bind to a nanoelectronic biosensor and increase this rate by blocking upstream binding sites.
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Applying microdroplets as sensors for label-free detection of chemical reactions

Lab Chip, 2012, 12,916-922
DOI: 10.1039/C2LC20971C, Paper

Tobias W. Hofmann, Siegfried Hanselmann, Jan-Wilhelm Janiesch, Anne Rademacher, Christian H. J. Bohm
We present a novel sensor method which exploits changes in the size of microdroplets driven by osmotic pressure differences as a label-free marker for reactions inside the droplets.
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A multifunctional pipette

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20906C, Paper

Alar Ainla, Gavin D. M. Jeffries, Ralf Brune, Owe Orwar, Aldo Jesorka
A multifunctional solution handling and dispensing tool, using hydrodynamically confined flow, to deliver solutions in a contamination free manner within single cell environments.
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Research highlights

Lab Chip, 2012, 12,677-679
DOI: 10.1039/C2LC90006H, Highlight

Seila Selimovic, Ali Khademhosseini
Self-assembled curved microdevices - Immunomagnetic hooks for capturing circulating tumor cells - Microfluidics for geological studies
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