RSC - Lab Chip latest articles

Improved oxygenation and hemocompatibility for microfluidic artificial lung via membrane microstreaming

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00360E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Anthony Mercader, Sang-Ho Ye, William R. Wagner, Sung Kwon Cho
This article presents a gas-exchange device featuring active mixing in blood via acoustic microstreaming driven by an oscillating membrane, enhancing oxygenation performance and hemocompatibility towards microfluidic artificial lung technology.
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Centrifugal microfluidics for rapid target analyte quantification in airborne bioaerosols

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00061D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Soongwon Cho, Michael Brothers, Ziyu Chen, Samet Şahin, Yirui Xiong, Nicole Schaeublin, Doug Adkins, Charles Call, Anthony Banks, Steve S. Kim, John A. Rogers
The PDMS-based lab-on-a-CD ELISA platform enables rapid on-site detection of airborne bioaerosols with minimal sample volume.
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Direct observation of anomalous CO2 dispersion in multi-scale porous media

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00244G, Paper

Qihui Wu, Yulin Zhang, Yibo Yang, Jun Yao, Yongfei Yang, Hai Sun, Lei Zhang, Junjie Zhong
“Rock-on-a-chip” technology enables direct observation of CO₂ dispersion dynamics in multi-scale porous media.
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Light-guiding capillaries: a robust optofluidic platform for nanoparticle tracking analysis

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00339G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Torsten Wieduwilt, Matthias Zeisberger, Walter Hauswald, Adrian Lorenz, Shayan Vazirieh Lenjani, Christian Rossner, Markus A. Schmidt
A fiber-integrated platform for nanoparticle tracking analysis based on fiber-like capillary structures that achieves high performance comparable to more complex microstructured fibers is presented.
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Large field of view fluorescence imaging of microfluidic devices with a tandem-lens macroscope

Lab Chip, 2026, 26,3662-3669
DOI: 10.1039/D5LC00959F, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Daniel A. Mokhtari, Ali Lashkaripour, Polly M. Fordyce
An automated transfluorescence tandem-macro-lens optomechanical system (macroscope) capable of sensitive, multi-channel fluorescence imaging over a very large field of view (34 mm diameter, 740 square mm) and with low-micron resolution.
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Correction: Rapid pan-cancer detection via label-free impedance profiling of cell-free DNA

Lab Chip, 2026, 26,3905-3905
DOI: 10.1039/D6LC90051H, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tejal Dube, Puja Prasad, Pragya Swami, Ankita Singh, Meenakshi Verma, Parul Tanwar, Shantanu Chowdhury, Shalini Gupta
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Modular microfluidic probe for addressable fluidic landscapes

Lab Chip, 2026, 26,3891-3904
DOI: 10.1039/D6LC00133E, Paper

Ayoub Glia, Muhammedin Deliorman, Mohammad A. Qasaimeh
Plug-and-play IPOF microfluidics converts open-space flows into addressable chemical nodes for programmable reagent delivery, gradient discretization, and multiplexed surface patterning.
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Vacuum-enhanced high-resolution 3D printing yields 11 200 valves and uniform 7 μm isoporous membranes

Lab Chip, 2026, 26,3838-3850
DOI: 10.1039/D6LC00100A, Paper

Dallin S. Miner, Timothy B. Skaggs, Barrett W. Schafer, Heidi E. Hunter, Troy Munro, Adam T. Woolley, Gregory P. Nordin
Vacuum-enhanced high-resolution 3D printing enables scalable, high-density microfluidic fabrication, as demonstrated by the reliable production of 11 200 membrane valves and 198 uniform 7 μm isoporous membranes across the full print area.
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Microfluidic insights into microbial impacts on hydrogen flow in underground hydrogen storage

Lab Chip, 2026, 26,3781-3795
DOI: 10.1039/D6LC00206D, Paper

Yuyi Liu, Diansen Yang
Underground hydrogen storage, involving periodic injection and extraction of hydrogen gas, serves as a crucial approach for achieving energy peak shaving and accommodating large-scale renewable energy.
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Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics

Lab Chip, 2026, 26,3617-3661
DOI: 10.1039/D5LC00957J, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ty Naquin, Chloe Naquin, Qian Wu, Ying Chen, Aidan Canning, Kaichun Yang, Yuna Li, Shuaiguo Zhao, Yun Ling, Zhiteng Ma, Ke Jin, Ye He, Shujie Yang, Luke P. Lee, Tony Jun Huang
Integrated microfluidic biosensors have rapidly evolved into powerful platforms to meet the increasing demand for ultrasensitive and high-throughput quantitative analysis.
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Creating an improved workflow for paper-based malaria diagnostics by integrating total lysis of whole blood

Lab Chip, 2026, 26,3762-3769
DOI: 10.1039/D6LC00145A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

J. Prat-Trunas, A. Code, Y. Avalos-Padilla, X. Fernández-Busquets, C. R. Mace, E. Baldrich
Three-dimensional paper-based lysis device fabricated by laser cutting or by wax printing that achieves 100% cellular lysis independent of sample composition, facilitating detection of a malaria biomarker and sample storage for 1 week at RT.
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A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates

Lab Chip, 2026, 26,3825-3837
DOI: 10.1039/D6LC00143B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Avi Gupta, Jacqueline Van Zyl, Collin Bushey, Peter Shankles, Hoseyn A. Amiri, Guillem Pratx, Alexander Alexeev, Todd Sulchek
Narrow, parallelized channels reveal a dynamic loading regime that, when integrated with geometry, flow, single-cell kinematics, and delivery outcomes, defines a mechanistic framework for microfluidic mechanoporation.
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Droplet microfluidic profiling of NK cell cytotoxicity with machine learning-enabled target-cell death analysis

Lab Chip, 2026, 26,3743-3761
DOI: 10.1039/D6LC00301J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Rana S. Ozcan, Fatemeh Vahedi, Shina Namakian, Ali A. Ashkar, Tohid F. Didar
A droplet microfluidic workflow combines ML-based K562 death analysis with manual NK annotation to quantify attachment, killing, serial killing, and killing-time differences across primary, expanded, and tumor-conditioned NK cells.
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3D stamp-integrated open-top microfluidic organ-on-a-chip for high-fidelity and functional reconstruction of vascularized microtissue models

Lab Chip, 2026, 26,3686-3702
DOI: 10.1039/D6LC00096G, Paper

Chenyang Zhou, Feifan Wang, Jiaqi Xu, Aochen Wang, Hanping Song, Luyao Wei, Guoxiang Fu, Xiaolin Wang
A open-top microfluidic organ-on-a-chip that integrates stamp-based patterning with sequential cellular assembly to achieve simultaneous construction of organ-specific topological architectures and perfusable vascular networks.
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Local chemotactic response of Escherichia coli in fluid and near surfaces

Lab Chip, 2026, 26,3865-3876
DOI: 10.1039/D5LC01048A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Adam Gargasson, Julien Bouvard, Carine Douarche, Peter Mergaert, Harold Auradou
Bacteria can adjust their swimming behaviour in response to chemical variations, a phenomenon known as chemotaxis. Their chemotactic sensibility is logarithmic, and greatly reduced on surfaces.
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Exploring paclitaxel–albumin-loaded neutrophil-like cells via microfluidic-based mechanical deformation for enhanced cargo delivery in glioblastoma therapy

Lab Chip, 2026, 26,3796-3809
DOI: 10.1039/D5LC01140J, Paper

Daidi Zhou, Xinghua Gao, Zhiyu Mao, Xiaoling Yang, Jingyun Ma, Ekaterina Andreevna Vorotelyak, Guohui Hu, Fengping Zhu, Jinbo Wu
This study investigated the rapid drug delivery capabilities of neutrophil-like cells using a microfluidic chip-based mechanical deformation approach, with an emphasis on glioblastoma treatment at the cellular level.
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High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

Lab Chip, 2026, 26,3810-3824
DOI: 10.1039/D5LC01050K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alexander Bevacqua, Do Hyun Park, Sheryar Khan, Qingxuan Li, Mahsa Hadidi, Jianzhu Chen, Jongyoon Han
A 25-layer spiral microfluidic device significantly reduces cell biomass from high-turbidity feedstock using inertial focusing to perform primary clarification and harvest adeno-associated virus (AAV) vectors at 20 mL min⁻¹ with 85% vector recovery.
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Lab-on-a-chip systems for microplastic and nanoplastic sampling, detection, characterization and bioassessment

Lab Chip, 2026, 26,3602-3616
DOI: 10.1039/D6LC00116E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Liyuan Gong, Erfan Eskandari, Md Iftakhar Khan, Yang Lin
Integrated lab-on-a-chip systems enable streamlined sampling, detection, characterization, and bioassessment of micro- and nanoplastics, bridging environmental monitoring with human health risk assessment.
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A microfluidic dermal fibroblast–macrophage co-culture on a chip linking inflammatory signalling to barrier-associated function

Lab Chip, 2026, 26,3877-3890
DOI: 10.1039/D6LC00175K, Paper

Preeda Larpthavee, Thitikorn Chomthong, Pareesa Pormrungruang, Suvimol Surassmo, Sakon Rahong
Immune-responsive microfluidics integrates dermal fibroblast–macrophage co-culture in 3D collagen to model inflammation. LPS induces NO/TNF-α responses, while nanocarriers suppress inflammation and restore ECM, enabling fast, animal-free drug screening.
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A microfluidic approach to evaluating surface protection from nonspecific antibody adsorption

Lab Chip, 2026, 26,3851-3864
DOI: 10.1039/D6LC00197A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yulia Tobolovskaya, Bexi M. Bustillo-Perez, Yingshan Ma, Nadine Löw, Ophélie Zeyons, Daniel A. Richards, Eugenia Kumacheva
A fluorescence assay-based microfluidic approach for real-time studies of the surface adsorption of antibodies and high-throughput screening of anti-biofouling compounds.
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Experimental diffusiophoresis of porous and non-porous silica particles in dead-end pore microchannel geometry

Lab Chip, 2026, 26,3770-3780
DOI: 10.1039/D5LC01020A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mansoureh Rashidi, Matina Nooryani, Giovanniantonio Natale, Anne M. Benneker
The movement of colloids in a solute concentration gradient plays a crucial role in applications, including separations, sorting and reactant transport. We show that porous particles respond different to solute gradients than solid particles.
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A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

Lab Chip, 2026, 26,3703-3713
DOI: 10.1039/D6LC00182C, Paper

Shogo Iwai, Daisuke Sasaki, Tetsutaro Kikuchi, Katsuhisa Matsuura, Kenjiro Fukuda, Sunghoon Lee, Tatsuya Shimizu, Takao Someya, Shinjiro Umezu
An ultrathin, stretchable nanomesh-based system enables contractile force measurement of cardiac tissue under mechanical stretch. It demonstrates stretch-dependent increases in contractile force and drug responses.
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Rapid fabrication of solvent-compatible NOA 81 microfluidic devices for double-emulsion microfluidics

Lab Chip, 2026, 26,3735-3742
DOI: 10.1039/D6LC00045B, Paper

Ryan Garry, Vladimir Sincari, Wentao Xu, Anurag Dhande, David A. Weitz
Rapid, low-cost organic solvent-compatible microfluidic device with localized surface modification for w/o/w emulsion templating of capsules and giant unilamellar vesicles.
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A rapid in situ synthesis of bioinspired nanoflowers on a microfluidic dipstick for point-of-care diagnosis of normoglycemic glycosuria

Lab Chip, 2026, 26,3670-3685
DOI: 10.1039/D6LC00086J, Paper

Saminu Abdullahi, Mohamed Ishag Hassan Gama, Mubashir Ali, Zhu Yang, Han Yujia, Jinzhen Li, Yuhang Liu, Xuzhong Wang, Zedong Nie
Rapid in situ growth of enzyme–Cu hybrid nanoflowers on paper enables an ultrasensitive microfluidic dipstick for smartphone-assisted detection of normoglycemic glycosuria.
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Highly sensitive wireless dual-spiral resonant contact lens for continuous intraocular pressure monitoring

Lab Chip, 2026, 26,3714-3724
DOI: 10.1039/D5LC00940E, Paper

Ying Liu, Zhixian Chen, Xiaoyu Zhao, Lin Xu, Shengli Mi
A highly sensitive wireless contact lens featuring an axisymmetric dual-spiral resonator enables continuous, non-invasive intraocular pressure monitoring for glaucoma management.
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Sequential intracellular delivery of genetic coding molecules using an acoustic electric microfluidic platform

Lab Chip, 2026, 26,3725-3734
DOI: 10.1039/D5LC00941C, Paper

Michelle Zhang, Aida Z. Taravatfard, Mohammad Aghaamoo, Abraham P. Lee
Acoustic microstreaming vortices enable high-throughput cell trapping and sequential delivery of plasmid DNA and Cas9 RNP, boosting transfection up to sevenfold by eliminating cargo competition and/or interaction.
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Centrifugal microfluidic automation of the protein aggregation capture workflow for robust mass spectrometry-based proteomics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00211K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Michelle Hinrichs, Johanna Wallner, Johanna Thiery, Carolin Kleber, Manuel Metzger, Stephan A. Sieber, Tobias Hutzenlaub, Oliver Schilling, Nils Paust, Hannes Hahne, Jan Muntel, Jan-Niklas Klatt
The AutoPAC-disk is a centrifugal microfluidic disk for protein aggregation capture-based sample preparation in bottom-up proteomics, enabling automated on-bead proteolysis with pre-stored buffers.
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Review of Nanofluidic Mass Transport Systems: Engineering through Physicochemical Fields and Interfacial Properties

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00329J, Perspective

Dongwoo Seo, Taesung Kim
Nanofluidic transport phenomena are central to both natural and engineered systems, enabling processes such as nutrient delivery and ion exchange in biological organisms, as well as controlled transport in advanced...
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Dynamic biomimicry in skin-on-a-chip: multi-scale construction to translational dermatology, drug screening and cosmetic evaluation

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01173F, Critical Review

Linwei Sang, Ajing Liu, Haochen Wang, Wanyi Li, Qin Tu, Jinyi Wang
This review discusses skin-on-a-chip advances through the lens of dynamic biomimicry. It focuses on engineering dynamic skin microenvironments in vitro and their applications in disease modelling, drug screening, and cosmetic evaluation.
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Machine-Embroidered Textile Electrodes: Parametric Engineering for Lab-on-Glove Electrochemical Pesticide Detection

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00452K, Paper

K. S. Deepak, Arshad Javed, Sanket Goel, Satish Kumar Dubey
Wearable Lab-on-glove systems offer the possibility of in-situ electrochemical analysis for non-destructive detection by enabling direct human-surface interaction. However, scalable fabrication and mechanistic understanding of textile electrode architectures remain underdeveloped....
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Adeno-associated viral vector purification using a centrifugal microfluidic system: towards workflow automation for low-volume sample processing

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00382F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Matthias Geissler, Lidija Malic, Liviu Clime, Dillon Da Fonte, Christina Nassif, Mojra Janta-Polczynski, Caroline Miville-Godin, Daniel Brassard, Nasha Nassoury, Richard Gingras, Nazila Nazemi-Moghaddam, Parminder Singh Chahal, Rénald Gilbert, Teodor Veres
AAV vectors are purified using a polymer-based microfluidic cartridge that features an embedded solid-phase extraction matrix and a layout that is compatible with workflow automation and low-volume sample processing.
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Integrating Microchannels and Flows into 3D Printable Granular Hydrogel Matrices

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC00219B, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Emily Ferrarese, Emily Swanekamp, Thuy-Vi Bui, Matthew J. Lazzara, Christopher B. Highley
Microfluidic systems incorporating or contained within hydrogels are important in creating microphysiological systems (MPSs). Often naturally derived hydrogels are used, as their inherent bioactivity supports dynamic cellular behaviors. Hydrogel biomaterials...
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Bridging dimensions: Combining one-and two-photon 3D printing for microfluidic device fabrication

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00261G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Oliver Walker, Robin R Benedix, Julian Fischer, Kai Hirzel, Cosima Stubenrauch, Michael Heymann
Additive manufacturing has been invaluable for 3D microfluidic integration. We combine high-resolution two-photon printed microfluidic features with fast one-photon printing to reduce overall fabrication time by about 20fold without compromising...
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A dual-mode vertical flow assay for species-specific identification and total bacteria load assessment from a single urine sample

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00265J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shu-Yun Sheu, Ching-Fen Shen, Chao-Min Cheng
Rapid urine screening requires simultaneous pathogen identification and clinically relevant bacteria burden assessment, yet most paper-based assays provide only one of these outputs.
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Acoustofluidic trapping of microparticles to axially centered wires in cylindrical microcapillaries

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00047A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ruben J. Trujillo, Phung H. Bui, Andrew P. Shreve, Matthew J. Campen, Menake E. Piyasena, Steven W. Graves
Acoustofluidic trapping in cylindrical microcapillaries concentrates microparticles onto an axially centered micro-wire, demonstrating particle trapping to a suspended microstructure in flowing microfluidic systems.
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Traumatic brain injury-on-a-chip: a microfluidic device for the compression of cortical spheroids

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00058D, Paper

Mauricio Araiza Canizales, Alexander McGhee, Yang Wan, Jing Zhang, Emily Blick, Rafael D. González-Cruz, Diane Hoffman-Kim, Haneesh Kesari, Christian Franck
A three-layer microfluidic platform for in situ compression, staining and monitoring of cortical spheroids to study mild traumatic brain injury.
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Mechanoadaptive root growth in Medicago sativa under controlled microhydrodynamic environments

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00827A, Paper

Doh-Won Yi, Jeongmok Kim, Joong Yull Park
A microfluidic plant-on-a-chip platform reveals a hydrodynamic threshold governing Medicago sativa root and root hair growth, as quantified by CFD simulations.
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3D printing monolithic, multifunctional polymer acoustofluidic devices with tunable mixing and particle focusing

Lab Chip, 2026, 26,3381-3391
DOI: 10.1039/D6LC00107F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Roxanne Kate Balanay, Justin W. Yip, Justin Do, Omair Adil, Keith Johnson, Tyler R. Ray
Acoustic forces offer a powerful, contact-free modality for manipulating particles and fluids within microfluidic lab-on-a-chip systems.
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Point-of-care SERS platforms: integrating microfluidics and machine learning for disease screening

Lab Chip, 2026, 26,3282-3319
DOI: 10.1039/D6LC00202A, Critical Review

Biqing Chen, Xiaohong Qiu, Yang Li
Microfluidic SERS platforms enable ultrasensitive, high-throughput bioanalysis via Raman enhancement and microfluidic control. Plasmonic integration supports multiplexed biomarker detection for biomedical research and clinical translation.
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Multiplexed nanophotonic biosensing and deep learning-driven protein quantification for traumatic brain injury diagnosis at the point of care

Lab Chip, 2026, 26,3555-3581
DOI: 10.1039/D5LC01079A, Paper

Jiayu Liu, Yuxin Wang, Shichao Su, Meng Su, Wenying Lv, Zhao Gao, Congwei Liu, Yanteng Li, Junzhao Sun, Peng Wang, Baorui Guo, Fan Yang, Renke He, Yanlin Song, Zeying Zhang, Jianning Zhang, Gang Cheng
This integrated nanophotonic biosensor platform enables multiplex detection of TBI biomarkers through an end-to-end process, offering a rapid, ultrasensitive, and field-deployable solution for acute brain injury diagnostics.
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A portable modular acoustic streaming vortex platform for flexible and robust fabrication of monodisperse micromaterials

Lab Chip, 2026, 26,3546-3554
DOI: 10.1039/D6LC00054A, Paper

Xiaoping Miao, Tianao Chen, Jijie Fu, Shilu Zhu, Mei Lan, Huayi Fu, Zhiqiang Zhu, Mingzhai Sun, Ronald X. Xu
A modular acoustic streaming vortex (MASV) platform has been developed for off-chip production of monodisperse microdroplets with broad size tunability and versatile viscoelastic properties.
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Thin stencil membrane-assisted high throughput single-cell to cluster of cells micropatterning and large-size biomolecular transfection in primary and stem cells

Lab Chip, 2026, 26,3508-3527
DOI: 10.1039/D6LC00164E, Paper

Donia Dominic, Srabani Kar, Rajdeep Ojha, Moeto Nagai, Tuhin Subhra Santra
Schematic illustration of high-throughput biomolecular delivery in single-cell patterns. Pulsed laser scanning-activated photoporation mediated through a micropatterned rGO device facilitates intracellular delivery in cell micropatterns.
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Valved microfluidics with Ostemers

Lab Chip, 2026, 26,3473-3484
DOI: 10.1039/D5LC00968E, Paper

Naveen Kumar K. R., Saima Hamid, A. K. Niketa, Ekta Prajapati, Shishir Kumar
Ostemer-based valved microfluidics with NOA 84 as a membrane replace PDMS using a three-layer design enables 200 ms switching time with strong chemical resistance, enabling robust and flexible microfluidic systems.
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Microfluidic profiling of suspension cell–metal adhesion at single-cell resolution under flow

Lab Chip, 2026, 26,3582-3590
DOI: 10.1039/D5LC01090J, Paper

Eunyoung Park, Seungjin Kang, Jieung Oh, Sangwoo Kim, Ung Hyun Ko
High-throughput quantification of cell–metal adhesion using single-cell transit velocity measurements in a microfluidic channel.
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An AI-enabled tool for quantifying overlapping red blood cell sickling dynamics in microfluidic assays

Lab Chip, 2026, 26,3366-3380
DOI: 10.1039/D6LC00108D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Nikhil Kadivar, Guansheng Li, Jianlu Zheng, Ming Dao, George Em Karniadakis, Mengjia Xu
AI-assisted masks train nnU-Net to predict cell masks, followed by optional watershed refinement, labeling, counting, and sickling analysis.
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Nanomembrane-based microfluidic platform with embedded electrical pressure transducer for on-chip nanoparticle quantification

Lab Chip, 2026, 26,3447-3458
DOI: 10.1039/D6LC00071A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Zachary Morris, Juliana Chawich, Owen Perreault, Simon Chewchuk, Kate Gragg, Vincent Tabard-Cossa, James L. McGrath, Michel Godin
A microfluidic device with an integrated PDMS pressure transducer and a nanoporous membrane to capture nanoparticles. A predictive algorithm then infers particle concentration in solution from the dynamics of pressure change within the microchannels.
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On cloud microfluidic experiment platform powered by in situ maskless lithography

Lab Chip, 2026, 26,3413-3424
DOI: 10.1039/D6LC00035E, Paper

Ratul Paul, Declan Coster, Yuwen Zhao, Yi Liu, Yaling Liu
Cloud microfluidic platform for remote design, fabrication, and testing via maskless lithography. Integrates microscopy, flow control, and analysis, enabling users to create devices, run experiments, and access data online for research and education.
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A novel 3D-printed tool for in vitro cell interaction studies under flow conditions

Lab Chip, 2026, 26,3528-3545
DOI: 10.1039/D6LC00033A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Katharina Skoll, Maria Zobl, Elke Heiss, Barbara Braunboeck, Samuel Meerkatz, Franz Radner, Samuel Castonguay, Markus Holzner, Adriana Zbiral, Michael Wirth, Maria Anzengruber
Experimental setup, sedimentation and shear stress influence cell interaction exposing the limits of static in vitro assays. The FlowCube emerges as a versatile, accessible platform that enables in vitro evaluation in a dynamic flow setting.
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Capillary microsampling enables on-site collection and storage of plant sap

Lab Chip, 2026, 26,3485-3492
DOI: 10.1039/D6LC00201C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ellinor Hedberg, Jaime Sebastián-Azcona, Federico Ribet, Virginia Hernandez-Santana, Göran Stemme, Antonio Diaz Espejo, Niclas Roxhed
A novel microfluidic plant sap sampling and storage device inspired by the concept of DBS, providing a practical alternative to destructive methods, supporting repeated sampling from the same plant and enabling longitudinal metabolic monitoring.
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Dynamic gap structure for high-throughput measurement of cellular mechanical properties

Lab Chip, 2026, 26,3435-3446
DOI: 10.1039/D5LC01162K, Paper

Doudou Ma, Nobutoshi Ota, Masaya Taniguchi, Yu-Hau Ye, Yuri Ito, Kazunori Okano, Naomi Tanga, Yoichiroh Hosokawa, Kazuya Sakai, Yo Tanaka, Koki Yamamoto, Yaxiaer Yalikun
Pressure-tunable dynamic gap in an all-glass microfluidic device enables clog-resistant, high-throughput cell mechanotyping via defined compression, quantifying apparent Young's modulus as a robust alternative to flow-based deformability cytometry.
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Independent parallel production of tunable blood clot analogues in hourglass-profiled circular PDMS fluidic channels

Lab Chip, 2026, 26,3425-3434
DOI: 10.1039/D6LC00190D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chun-Hsin Hsu, To-Wen Chen, Wei-Jen Soong, Chihchen Chen
A dual-loop flow system is presented, enabling parallel, independent blood clot analogue production in hourglass-profiled channels, with integrated reagent delivery, real-time imaging, and flow-rate monitoring.
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Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood–brain barrier on-chip through pro-inflammatory stimulation of immune cells

Lab Chip, 2026, 26,3327-3344
DOI: 10.1039/D6LC00067C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Louis P. Widom, Panteha Torabian, Michelle A. Trempel, Molly C. McCloskey, Lea V. Michel, James L. McGrath, Thomas R. Gaborski
Conditioned medium from macrophages stimulated with Escherichia coli-derived bacterial extracellular vesicles (BEVs) caused disruption of a human blood–brain barrier lab-on-chip, but direct BEV treatment did not cause a similar disruptive effect.
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Flow-programmable and reversible surface-induced LLPS in nanofluidic channels

Lab Chip, 2026, 26,3493-3507
DOI: 10.1039/D6LC00003G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ryoichi Ohta, Zhixin Zhao, Xuan Yan, Ruying Wang, Kazuma Mawatari
Nanofluidic confinement enables instantaneous formation and hydrodynamic peel-off of surface LLPS films. In the future, this reversible 3D phase is expected to accommodate functional molecules beyond static 2D limits.
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Gut–liver-on-a-chip enables mechanistic study and risk assessment of drug-induced liver injury and drug–drug interactions

Lab Chip, 2026, 26,3345-3365
DOI: 10.1039/D5LC01094B, Paper

Yue Yu, Tian Lin, Xiao Ye, Yupeng Wang, Rongrong Xiao, Baiyang Sun, Manman Zhao, Jie Song, Bo Li, Xiaobing Zhou
A gut–liver-on-chip was established to conduct case studies of the toxicity–exposure relationship, time-dependent hepatotoxicity, enzyme/transporter-mediated drug–drug interaction studies, and first-pass effects.
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Size-based sorting of cancer cells reveals functional heterogeneity among subpopulations

Lab Chip, 2026, 26,3459-3472
DOI: 10.1039/D5LC01042J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Esra Yilmaz, Zhimeng Fan, Jason P. Beech, Vinay S. Swaminathan, Jonas O. Tegenfeldt
Cancer cells of type MDA-MB-231 were sorted based on size using deterministic lateral displacement. The results reveal differences with respect to size in morphology, adhesion dynamics, and invasion potential.
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Fluid mechanics of thin blood films to detect anemia and sickle cell disease

Lab Chip, 2026, 26,3401-3412
DOI: 10.1039/D5LC00943J, Paper

Mahrukh A. Mir, Mahesh S. Tirumkudulu, Bhavesh Raicha
We determine the viscosity of blood from the length of blood smears. Viscosity below a threshold indicates anemia, while viscosity increase due to stiffening of red blood cells upon deoxygenation indicates sickle cell disease.
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Development of a nasal airway-on-chip co-culture model to study particulate matter exposure

Lab Chip, 2026, 26,3392-3400
DOI: 10.1039/D5LC00978B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Amanda C. Walls, Adrienne S. Vaughan, Kartik Balachandran
A nasal airway-on-chip designed for culture of nasal epithelial and endothelial cells in co-culture with the epithelial cells in air–liquid interface culture and exposed to physiological breathing airflows.
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Polydiacetylene (PDA) coated paper-based fluorescence sensor for the detection and quantification of bisphenol

Lab Chip, 2026, 26,3320-3326
DOI: 10.1039/D5LC00821B, Communication

Gayathri Loganathan, Shubham Gurav, Khaja Moinuddin Shaik, Pirangi Srikanth, Aman Bhardwaj, Sukhendu Nandi
An innovative portable point-of-care device that rapidly and accurately detects and quantifies bisphenol. This sensor ensures quick results, making it an indispensable tool for health and safety monitoring.
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Deterministic radial displacement: modular, reconfigurable, and reusable

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00348F, Paper

Sean C. McCabe, Shilun Feng, David W. Inglis
By cylindrically revolving a DLD array, devices can be fabricated in segments and simply assembled, delivery modularity and reusability.
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Tunable Self-Assembling Cellular Microarray for Single-Neutrophil Vital and Suicidal Extracellular Traps

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01156F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jacob Doon-Ralls, Sophia Mayone, Xilal Y. Rima, Dharti Shantaram, Kim Truc Nguyen, Ajeet Singh, Bradley J. Needleman, Sabrena Noria, Stacy Brethauer, Kyle A. Perry, David Wood, Anahita D. Jalilvand, Willa A. Hsueh, Eduardo Reátegui
Neutrophils, the innate immune system's first line of defense, function in pathogen removal through diverse cellular responses. One critical response is neutrophil extracellular trap (NET) formation, which, despite its importance...
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Capillary flow-driven paper-based microfluidic sensor for NDMA detection in water

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00165C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Prakash Aryal, Jade Manna-Rubenstein, Tessa Whitaker, Eric Brack, Charles S. Henry
Detection of N-nitrosodimethylamine (NDMA) via on-chip photonitrosation followed by dual colorimetric detection using two complementary metal complexation systems.
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A quantitative rapid test for urine creatinine via Fenton's reaction and a self-driven microfluidic device

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00249H, Paper

Hogi Hartanto, Jiaheng Li, Cheuk Chun Szeto, Ting-Hsuan Chen
A self-driven microfluidic chip converting urine creatinine into a length of a visual bar using creatinine's inhibition to Fenton's reaction, achieving limit of detection of 20.11 mg dL⁻¹ and high compatibility with clinical urine samples.
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Auto-SELEX: a fully automated microfluidic platform for rapid discovery of high-affinity aptamers

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00275G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yang Bu, Yuze Liu, Anni Hu, Yung Ching Lee, Levent Yobas
A fully automated microfluidic SELEX that accelerates weeks-long aptamer discovery to 30 min selection rounds by integrating free-solution electrokinetic partitioning through an artificial sieve with plasmonic bead-based PCR using Au nanorods.
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