RSC - Lab Chip latest articles

A Microfluidic Approach to Evaluating Surface Protection from Nonspecific Antibody Adsorption

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00197A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yulia Tobolovskaya, M Bustillo-Perez, Yingshan Ma, Nadine Löw, Ophelie Zeyons, Daniel Ashley Richards, Eugenia Kumacheva
Nonspecific antibody adsorption to solid surfaces remains a challenge in the development and use of formulations for immunotherapies, as it can compromise antibody structure and therapeutic function. Here, we introduce...
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Microfluidic Profiling of Suspension Cell-Metal Adhesion at Single-Cell Resolution Under Flow

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01090J, Paper

Eunyoung Park, Seungjin Kang, Jieung Oh, Sangwoo Kim, Ung Hyun Ko
Metallic implants used in vascular applications must maintain functionality under dynamic blood flow conditions. A critical factor affecting their performance is the unintended adhesion of blood cells, including red blood...
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Experimental Diffusiophoresis of Porous and Non-Porous Silica Particles in Dead-End Pore Microchannel Geometry

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01020A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mansoureh Rashidi, Matina Nooryani, Giovanniantonio Natale, Anne Benneker
The movement of colloids in response to a concentration gradient of solutes, known as diffusiophoresis (DP), plays a crucial role in various applications, including separations, sorting and reactant transport. In...
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An AI-enabled tool for quantifying overlapping red blood cell sickling dynamics in microfluidic assays

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00108D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Nikhil Kadivar, guansheng Li, Jianlu Zheng, Ming Dao, George Em Karniadakis, Mengjia Xu
Understanding sickle cell dynamics requires accurate identification of morphological transitions under diverse biophysical conditions, particularly in densely packed and overlapping cell populations. In microfluidic sickling assays, simple dilution to reduce...
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A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00182C, Paper

Shogo Iwai, Daisuke Sasaki, Tetsutaro Kikuchi, Katsuhisa Matsuura, Kenjiro Fukuda, Sunghoon Lee, Tatsuya Shimizu, Takao Someya, Shinjiro Umezu
An ultrathin, stretchable nanomesh-based system enables contractile force measurement of cardiac tissue under mechanical stretch. It demonstrates stretch-dependent increases in contractile force and drug responses.
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Size-based sorting of cancer cells reveals functional heterogeneity among subpopulations

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01042J, Paper

Open Access

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Esra Yilmaz, Zhimeng Fan, Jason P. Beech, Vinay S. Swaminathan, Jonas O. Tegenfeldt
Cancer cells of type MDA-MB-231 were sorted based on size using deterministic lateral displacement. The results reveal differences with respect to size in morphology, adhesion dynamics, and invasion potential.
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Nanomembrane-based microfluidic platform with embedded electrical pressure transducer for on-chip nanoparticle quantification

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00071A, Paper

Open Access

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Zachary Morris, Juliana Chawich, Owen Perreault, Simon Chewchuk, Kate Gragg, Vincent Tabard-Cossa, James L. McGrath, Michel Godin
A microfluidic device with an integrated PDMS pressure transducer and a nanoporous membrane to capture nanoparticles. A predictive algorithm then infers particle concentration in solution from the dynamics of pressure change within the microchannels.
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Dynamic gap structure for high-throughput measurement of cellular mechanical properties

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01162K, Paper

Doudou Ma, Nobutoshi Ota, Masaya Taniguchi, Yu-Hau Ye, Yuri Ito, Kazunori Okano, Naomi Tanga, Yoichiroh Hosokawa, Kazuya Sakai, Yo Tanaka, Koki Yamamoto, Yaxiaer Yalikun
Pressure-tunable dynamic gap in an all-glass microfluidic device enables clog-resistant, high-throughput cell mechanotyping via defined compression, quantifying apparent Young's modulus as a robust alternative to flow-based deformability cytometry.
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Microfluidic compartmentalization reveals that ferrostatin-1 restores directional mitochondrial transport in Aβ-challenged neurons

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00834D, Paper

Open Access

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Nad'a Majerníková, Beatrice Corci, Yuequ Zhang, Tingting Chen, Maaike van Koeveringe, Denice Mensinga, Patty P. M. F. A. Mulder, Elisabeth Verpoorte, Andrea Mattarei, Diana Pendin, Cristina Mammucari, Christoffer Åberg, Wilfred den Dunnen, Amalia M. Dolga
Aβ_1–42 induces increased retrograde transport of axonal mitochondria and deregulation of mitochondrial calcium, which can be prevented by Fer-1.
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On cloud microfluidic experiment platform powered by in situ maskless lithography

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00035E, Paper

Ratul Paul, Declan Coster, Yuwen Zhao, Yi Liu, Yaling Liu
Cloud microfluidic platform for remote design, fabrication, and testing via maskless lithography. Integrates microscopy, flow control, and analysis, enabling users to create devices, run experiments, and access data online for research and education.
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Independent parallel production of tunable blood clot analogues in hourglass-profiled circular PDMS fluidic channels

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00190D, Paper

Open Access

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Chun-Hsin Hsu, To-Wen Chen, Wei-Jen Soong, Chihchen Chen
A dual-loop flow system is presented, enabling parallel, independent blood clot analogue production in hourglass-profiled channels, with integrated reagent delivery, real-time imaging, and flow-rate monitoring.
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Stretchable mesoporous electrodes as a versatile platform for minimally invasive surgical devices

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00110F, Paper

Open Access

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Michael Abraham Listyawan, Chi Cong Nguyen, Tran Bach Dang, Nhat Mihn Doan, Quang Anh Nguyen, Yulin Qiu, Eva Tomaskovic-Crook, Mostafa Kamal Masud, Yusuke Yamauchi, Jeremy Micah Crook, Mohit Naresh Shivdasani, Thanh Nho Do, Hoang-Phuong Phan
A scalable fabrication strategy to integrate thin, stretchable mesoporous electrodes onto catheters and soft robotic systems, enabling multifunctionalities including biopotential measurement, electrical stimulation, and bioimpedance sensing.
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A novel 3D-printed tool for in vitro cell interaction studies under flow conditions

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00033A, Paper

Open Access

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Katharina Skoll, Maria Zobl, Elke Heiss, Barbara Braunboeck, Samuel Meerkatz, Franz Radner, Samuel Castonguay, Markus Holzner, Adriana Zbiral, Michael Wirth, Maria Anzengruber
The interaction of drug formulations with cells is a critical factor in the development of effective therapeutics. Conventional in vitro models, such as static horizontal monolayer cultures, often fail to...
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Predicting human pharmacokinetic parameters of drugs using a multi-tissue chip platform integrating liver, kidney, and skeletal muscle microphysiological systems

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00008H, Paper

Jason Sherfey, Shiny Amala Priya Rajan, Lauren M. Nichols, Paarth Parekh, J. Tyler Smith, Lauren Gregory, Frances Clark, Eugene P. Kadar, Shivam Ohri, Billy T. George, David Tess, James R. Gosset, Jennifer Liras, Emily Geishecker, R. Scott Obach, Murat Cirit
A combinatorial NAM approach integrating multi-tissue chip with QSP modeling enables accurate prediction of human exposure for hepatically and renally cleared small molecules.
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Porous microneedle-based electrochemical aptamer biosensor for the collection and quantitative analysis of dry eye disease biomarkers

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00230G, Communication

Open Access

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Eira Beryle Ko, Tianli Hu, Ya Zhang, Xueyan Wang, Yu Song, Chenjie Xu
A porous microneedle-integrated electrochemical aptamer sensor allows for the rapid tear extraction and quantitative biomarker detection in a single device for dry eye disease.
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Ultra-high throughput droplet microfluidics for cultivation and functional screening of environmental microbial strains and consortia

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01115A, Tutorial Review

Luca Potenza, Jozef Krzak, Maciej S. Andrzejewski, Adam Pyzik, Tomasz S. Kaminski
The scheme illustrates a droplet microfluidic workflow for isolating microorganisms using high-throughput screening (HTS), in which individual cells are encapsulated in droplets, cultivated, sorted, and ultimately recovered as selected strains.
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A combinatorial screening platform for in situ gene delivery to adherent cells via digital microfluidics and flexible electrodes

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00124F, Paper

Yi Weng, Xiangyu Ren, Fuqiang Guo, Weichao Wu, Bin Wang, Chaobo Li
The PDES platform solves the bottlenecks of traditional electroporation methods: manual operation, high reagent use, and low throughput. The micro-level automated reaction system allows multidimensional orthogonal screening and fast optimization of electrical parameters and biological components.
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Rapid fabrication of solvent-compatible NOA 81 microfluidic devices for double-emulsion microfluidics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00045B, Paper

Ryan Garry, Vladimir Sincari, Wentao Xu, Anurag Dhande, David A. Weitz
Rapid, low-cost organic solvent-compatible microfluidic device with localized surface modification for w/o/w emulsion templating of capsules and giant unilamellar vesicles.
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Capillary microsampling enables on-site collection and storage of plant sap

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00201C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ellinor Hedberg, Jaime Sebastián-Azcona, Federico Ribet, Virginia Hernandez-Santana, Göran Stemme, Antonio Diaz Espejo, Niclas Roxhed
Plant sap analysis typically relies on destructive sampling and immediate freezing, limiting field deployment and longitudinal studies. We introduce a minimally invasive microfluidic device that extracts sap from the stem...
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Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00098C, Paper

Open Access

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Wenyang Jing, Heewon Noh, Timothy J. C. Tan, Nicholas C. Wu, Hee-Sun Han
Decoding dewetting dynamics in double emulsions establishes predictive rules for robust, tunable GUV assembly. This physics-based framework provides systematic guidance to optimize GUV production across varied lipid, aqueous, and fluidic parameters.
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Selective on-chip DNA synthesis using electric field-assisted PCR

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01200G, Paper

Doyeon Lim, Youngjun Song
An electric field-assisted PCR platform enables selective on-chip DNA synthesis with precise spatial control using microelectrode arrays. This scalable approach achieves high-efficiency enzymatic synthesis for DNA data storage and diagnostics.
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LEGO®-inspired electrically-actuated microfluidics for on-chip protein crystallization and in situ X-ray crystallography

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00021E, Paper

Sarthak Saha, Logan Chen, Gabrielle R. Budziszewski, Sara Koprek, Kaleb Seifert, Aina Cohen, Silvia Russi, Sarah E. J. Bowman, Sarah L. Perry
Low-voltage valve actuation to facilitate protein crystallization and in situ X-ray structure determination.
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Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery

Lab Chip, 2026, 26,2415-2438
DOI: 10.1039/D5LC01131K, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Doriane Le Manach, Vincent Senez, Matthias Nees
CAF-driven matrix remodeling creates quantifiable transport barriers to drug delivery. Tumor-on-chip platforms enable transport phenotyping to decode and target these stromal barriers.
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A rapid in situ synthesis of bioinspired nanoflowers on a microfluidic dipstick for point-of-care diagnosis of normoglycemic glycosuria

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00086J, Paper

Saminu Abdullahi, Mohamed Ishag Hassan Gama, Mubashir Ali, Zhu Yang, Han Yujia, Jinzhen Li, Yuhang Liu, Xuzhong Wang, Zedong Nie
Rapid in situ growth of enzyme–Cu hybrid nanoflowers on paper enables an ultrasensitive microfluidic dipstick for smartphone-assisted detection of normoglycemic glycosuria.
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Topology-based coordination control for multi-droplet tasks in autonomous digital microfluidics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00147E, Paper

Kunlun Guo, Zerui Song, Boyi Feng, Tiaofen Qiu, Jiale Zhou, Bin Shen, Bingyong Yan, Zhen Gu, Huifeng Wang
An unmanned topology-based digital microfluidics control system is developed that integrates adaptive path planning with semantic segmentation feedback to achieve fully autonomous coordination of multi-unit droplets with dynamic morphologies.
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Correction: Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays

Lab Chip, 2026, 26,2622-2622
DOI: 10.1039/D6LC90032A, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ali Khademhosseini, Judy Yeh, George Eng, Jeffrey Karp, Hirokazu Kaji, Jeffrey Borenstein, Omid C. Farokhzad, Robert Langer
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Cell therapy manufacturing at full clinical scale: enhancing the quality CAR-T cell therapy starting materials through massively parallel automated microfluidic cell sorting

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00072J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alison M. Skelley, Yasna Behmardi, Luke F. Peterson, David W. Inglis, Mabel Shehada, Laurissa Ouaguia, Khushroo Gandhi, Roberto Campos-González, Tony Ward
Over N = 86 full scale apheresis samples, microfluidic DLD processing yielded significantly higher leukocyte recovery (88% vs. 58%), superior platelet and red blood cell depletion, and reduced CD69⁺ T cell activation compared to conventional Ficoll®.
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PDMS aqueous leachates cause acute toxicity in C. elegans

Lab Chip, 2026, 26,2612-2621
DOI: 10.1039/D6LC00017G, Paper

Open Access

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Kin Gomez, Kirill Efimenko, Jan Genzer, Adriana San-Miguel
Leachates from PDMS networks elicit acute toxicity in C. elegans that is strongly shaped by media composition and stress-response pathways. Cholesterol, salts, and transgenerational history determine organismal resilience to PDMS-derived components.
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In vitro space of Disse model for exploration of drug induced hepatotoxicity

Lab Chip, 2026, 26,2577-2588
DOI: 10.1039/D5LC01139F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ana Mesic, Antonietta Messina, Zoe Tiprez, Benoit Charlot, Safa Mohamed Ismail, Nicolas Huang, Sakina Bensalem, Jean-Charles Duclos-Vallee, Bruno Le Pioufle
A human-cell-derived liver-on-a-chip model integrating tunable alginate hydrogel and LSEC–HepaRG co-culture. Recapitulates sinusoidal architecture, with an emphasis on intercellular communication in the space of Disse.
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Vertical numbering-up microfluidic architecture for scalable and homogeneous lipid nanoparticle production

Lab Chip, 2026, 26,2601-2611
DOI: 10.1039/D5LC01130B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Zhaoyu Zhang, Jaejeung Kim, Jinwoo Hwang, Hyunjo Seo, Geonha Kim, Seoyeon Choi, Kyung-A Hyun, Hyo-ll Jung
A vertically stacked microfluidic chip enables scalable LNP production while preserving particle quality and therapeutic efficacy.
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Tunable squeeze-activated GHz acoustofluidics for stable trapping and separation of sub-100 nm nanoparticles

Lab Chip, 2026, 26,2506-2513
DOI: 10.1039/D6LC00106H, Paper

Yiming Liu, Wei Wei, Hang Qi, Shuaihua Zhang, Yongqi Chen, Yaping Wang, Xuexin Duan
Here we propose a tunable squeeze-activated GHz acoustofluidics (TSGA) platform, which enables continuous enrichment of particles down to 50 nm and high-resolution purification of exosome subpopulations.
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Digitally programmable microfluidic valving for autonomous, high-resolution continuous chromatographic purification

Lab Chip, 2026, 26,2565-2576
DOI: 10.1039/D6LC00015K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yi-Cheng Liao, Chih-Yi Huang, Yu-Chuan Tang, Cheng-Hsian Wu, Yu-Hsuan Chi, I-Wei Chen, Hsuan-Yu Mu, Ya-Hui Lin, Yunching Chen, Fu-Fei Hsu, Jen-Huang Huang
A programmable, single-use protein purification platform enables contamination-free and continuous workflows for sensitive or variable protein targets through digitally coordinating multistep buffer exchange and time-gated fraction collection.
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Integrated microfluidic platform for inertial separation and encapsulation of single cells in droplets

Lab Chip, 2026, 26,2589-2600
DOI: 10.1039/D6LC00085A, Paper

Fariba Malekpour Galogahi, Haotian Cha, Sharda Yadav, Hang Thu Ta, Nam-Trung Nguyen
This study presents an integrated microfluidic device for simultaneous size-based cell separation and on-chip encapsulation into droplets at single-cell resolution, enabling streamlined processing and efficient downstream single-cell analysis.
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Monolithic 3D-printed split-and-recombine micromixer integrated into a microfluidic concentration gradient generator

Lab Chip, 2026, 26,2531-2542
DOI: 10.1039/D5LC01095K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Francisco Navarro Molina, Jitendra Paliwal, Elham Salimi
Monolithic 3D-printed microfluidic device integrating a SAR micromixer and concentration gradient generator, with experimental validation across a broad Reynolds number (Re) range.
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A customizable, low-cost 3D-printed device for live cell confinement imaging

Lab Chip, 2026, 26,2543-2553
DOI: 10.1039/D5LC01146A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Hunter Richman, Jin Ou, Manpreet Khera, Yan Yu
A 3D-printed, light microscopy-compatible cell confinement device that delivers precise, tunable, and uniform confinement heights while enabling live-cell imaging.
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Machine learning-driven single-cell phenotyping in size-controlled microenvironments via parallel deterministic droplet microfluidics

Lab Chip, 2026, 26,2554-2564
DOI: 10.1039/D5LC00839E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sangmin Lee, Steven O'Donnell, Zhangli Peng, Jae-Won Shin
We present an integrated platform combining deterministic single-cell encapsulation across multiple microgel sizes with machine-learning analysis to identify size-dependent phenotypes and predict microenvironmental confinement.
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Machine learning-augmented lateral flow assays for point-of-care infectious disease diagnostics

Lab Chip, 2026, 26,2394-2414
DOI: 10.1039/D5LC01124H, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Cagla Parmaksizoglu, Isil Cakiroglu, Nazente Atceken, Eden Morales-Narváez, Ali K. Yetisen, Savas Tasoglu
Advances in LFAs for infectious diseases include nanomaterial engineering, CRISPR amplification, and multiplex designs for better sensitivity and quantitation. AI/ML enables smartphone-based objective analysis, despite standardization challenges, paving the way for connected PoC diagnostics.
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Multiphasic droplet microfluidics platform for controlled bacteria and mammalian cell co-culture

Lab Chip, 2026, 26,2473-2485
DOI: 10.1039/D6LC00016A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ibraheem Alshareedah, Anand Kumar
Polymer phase separation combined with microfluidics enables the generation of multiphasic droplets for high-throughput mammalian cell–bacteria co-culture.
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A microfluidic method for controlled generation and trapping of membraneless water-in-water droplets

Lab Chip, 2026, 26,2495-2505
DOI: 10.1039/D5LC01055A, Paper

Open Access

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Chi Li, Hailin Fu, Kalpit J. Bakal, Jaap M. J. den Toonder, E. W. Meijer, Sailing He, Hans M. Wyss
A robust microfluidic platform for liquid–liquid phase separation enables controllable formation, trapping, and reversible compartmentalization of water-in-water droplets in an open system, enabling dynamic studies of multiphase systems.
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Real-time impedance-based cell migration measurements with integrated electrodes on porous membranes for next generation microphysiological systems

Lab Chip, 2026, 26,2463-2472
DOI: 10.1039/D5LC00898K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Karina Torres-Castro, Aditya Rane, Darwin R. Reyes
Integrated sensors on both sides of a track-etched polyester membrane in this next generation microphysiological system enable real-time monitoring of cancer cell migration by simultaneously tracking impedance on both sides of the porous membrane.
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MaGIC-OT: an AI-guided optical tweezers platform for autonomous single-cell isolation in microfluidic devices

Lab Chip, 2026, 26,2451-2462
DOI: 10.1039/D5LC00738K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jan-Philipp Cieslik, Xiaoye Xia, Ali Salehi-Reyhani
MaGIC-OT automates optical tweezer-based single-cell isolation in microfluidic devices, enabling collision-free transport and high-purity delivery of rare cells from crowded biological samples.
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Real-time high-throughput characterisation of the surface elasticity of suspended cells

Lab Chip, 2026, 26,2514-2530
DOI: 10.1039/D5LC00909J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ziyu Guo, Yi Sui, Wen Wang
We integrate microfluidic, machine learning and high-fidelity cell mechanical modelling to build a system to enable real-time high-throughput characterization of the intrinsic surface elasticity of suspended cells.
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A tumor spheroid array chip for high-fidelity evaluation of liposomal drug delivery through the EPR effect

Lab Chip, 2026, 26,2439-2450
DOI: 10.1039/D5LC00893J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yedam Lee, Sujin Kim, Hyeyeon Koh, Yeonwoo Park, Jung Y. Han, Jihoon Ko
A microfluidic tumor–vasculature model enables evaluation of liposome-based anticancer therapies by assessing cancer cell death and anti-angiogenic effects under physiologically relevant conditions.
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Directed dielectrophoretic assembly and separation on microelectrodes patterned via stereolithography 3D-printed shadow masks

Lab Chip, 2026, 26,2486-2494
DOI: 10.1039/D5LC00829H, Paper

Eunhwa Jo, Chanwook Cha, Yeongjun Kim, Jeongjae Seo, Eun Jung Lee, Koohee Han
By employing an SLA-fabricated shadow mask for precise electrode patterning, this work demonstrates that dielectrophoretic separation and assembly can be robustly and reliably controlled.
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Estimating single-cell elastic modulus in a serial microfluidic cytometer from time-of-flight and fluorescence signals analysis

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00930H, Paper

Open Access

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Graylen R. Chickering, Leroy L. Jia, Matthew DiSalvo, Megan A. Catterton, Paul N. Patrone, Eric M. Darling, Gregory A. Cooksey
Particles can migrate in flow based on size and deformability, resulting in measurable time-of-flight differences. These same mechanical properties can reflect changes in cellular state, function, and disease.
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A microfluidic skin-on-a-chip enabling in situ construction of full-thickness human skin for modeling inflammatory diseases

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00189K, Paper

Linwei Sang, Ajing Liu, Junjie Zhu, Qian Yang, Zheng Liu, Shu-Wei Chen, Jinyi Wang
This study presents a detachable microfluidic skin-on-a-chip. Using epidermal–dermal co-culture under dynamic perfusion, the chip enables on-chip construction of inflammatory phenotype and drug evaluation.
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Region-specific proteomic profiling of brain interstitial fluid via a micro-invasive sampling platform

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00038J, Paper

Open Access

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Qun Cao, Hannah D. Jackson, Aidan J. Duncan, Yufei Cui, Haley O. Higginbotham, Stella Lesnik, Yunseo Jo, Jiaquan Yu, Forest M. White, Michael J. Cima
This study presents a localized, membrane-free method for sampling brain interstitial fluid, enabling high protein yield from small volumes. It uncovers proteomic differences across brain regions, supporting improved biomarker detection.
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A tunable 50 MHz acoustic vortex tweezer for size-selective manipulation and cell pre-concentration

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00010J, Paper

Xiongwei Wei, Xin Wang, Lili Miao, Yi Quan, Chunlong Fei, Yintang Yang
A tunable 50 MHz silicon metasurface vortex tweezer with M = 1, 3, 5 adjusts capture orbit (50–150 μm), enabling orbital rotation, size-selective manipulation and cell pre-concentration.
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Sequential intracellular delivery of genetic coding molecules using an acoustic electric microfluidic platform

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00941C, Paper

Michelle Zhang, Aida Z. Taravatfard, Mohammad Aghaamoo, Abraham P. Lee
Acoustic microstreaming vortices enable high-throughput cell trapping and sequential delivery of plasmid DNA and Cas9 RNP, boosting transfection up to sevenfold by eliminating cargo competition and/or interaction.
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Centrifuge-free separation of plasma from milliliters of whole blood for point-of-care diagnostics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00135A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Christia M. Victoriano, Bianca Arraiza Carlo, Abigail G. Ayers, Kelia A. Human, Samuel K. Sia
PlasmaLIFT enables automated plasma separation from milliliters of whole blood by integrating immunomagnetic red blood cell depletion with dual-membrane filtration.
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Human hair regeneration using organoids and hair-on-chip technologies

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00095A, Perspective

Imaan A. Ahmed, Abbas Shafiee
Currently, no therapies exist for regenerating appendage bearing skin. New developments in biofabrication, stem cell research, organoids, and other technologies hold promise for skin regeneration with optimal cosmetic and functional outcomes.
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A hypoxic microfluidic organoid-on-a-chip system for studying the efficacy of metronidazole-modified nanomaterials against cholangiocarcinoma established within the chip

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01198A, Paper

Ao Xie, Zipeng Yao, Qijun Du, Mengjiao Xia, Qinrui Lu, Jiashu Wang, Wenqi Hu, Lin Wu, Chenwei Sun, Youlong Yang, Di Wu, Haijie Hu, Guohua Wu, Shuqi Wang
This biomimetic organoid chip recapitulates tumor hypoxia to evaluate specific nanotherapeutics for personalized cholangiocarcinoma treatment.
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A compact low-power valveless piezoelectric micropump with a nested rectification structure

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00060F, Paper

Jie Shan, Aoyu Ma, Cuixue Ren, Yuren Zhao, Lixia Yang, Jingmin Li
A valveless piezoelectric micropump with a novel nested rectification structure achieves high net flow rate and low power consumption in a compact design. It shows promising potential for microfluidic chip systems and biofluid transport.
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High-throughput microfluidic platform for modelling inflammatory responses of human articular chondrocytes under variable fluid shear stress

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01167A, Paper

Open Access

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Aldeliane M. da Silva, Priscila Campioni Rodrigues, Meriem Lamghari, Hoang-Tuan Nguyen, Jere Kettunen, Sebastien Mosser, Prateek Singh, Ali Mobasheri, Gabriela S. Lorite
A scalable, pumpless microfluidic platform applies shear stress gradients and cytokine-driven inflammation to model osteoarthritis physiologically.
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A compact superlattice as a label-free surface-enhanced Raman scattering substrate for noninvasive urine testing for the diagnosis of lung cancer

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01177A, Paper

Kaili Zhang, Yuancai Ge, Yi Xu, Yujie Liu, Chaoyue Cui, Yuxin Liang, Yangxuan Lin, Jungeng Zhang, Qingwen Zhang, Yi Wang, Xiaoming Lin
A self-assembled compact superlattice is fabricated as a surface-enhanced Raman spectroscopy substrate to distinguish between urine samples from lung cancer patients, post-operative patients, and healthy persons with high accuracy and efficiency.
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Gut–liver-on-a-chip enables mechanistic study and risk assessment of drug-induced liver injury and drug–drug interactions

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01094B, Paper

Yue Yu, Tian Lin, Xiao Ye, Yupeng Wang, Rongrong Xiao, Baiyang Sun, Manman Zhao, Jie Song, Bo Li, Xiaobing Zhou
A gut–liver-on-chip was established to conduct case studies of the toxicity–exposure relationship, time-dependent hepatotoxicity, enzyme/transporter-mediated drug–drug interaction studies, and first-pass effects.
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Microfluidic well plates integrated with passive nematode culture chambers for multiplexed chemical toxicity assays in C. elegans

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01165E, Paper

Bushra Rahman, Purushottam Soni, Atiyya P. Saroyia, William Schenkenfelder, Siva A. Vanapalli
PNC well plates enable low-intervention, multiplexable C. elegans assays with translational potential for predictive toxicology.
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Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood–brain barrier on-chip through pro-inflammatory stimulation of immune cells

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00067C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Louis P. Widom, Panteha Torabian, Michelle A. Trempel, Molly C. McCloskey, Lea V. Michel, James L. McGrath, Thomas R. Gaborski
Conditioned medium from macrophages stimulated with Escherichia coli-derived bacterial extracellular vesicles (BEVs) caused disruption of a human blood–brain barrier lab-on-chip, but direct BEV treatment did not cause a similar disruptive effect.
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An automated modular microfluidic platform for end-to-end mRNA synthesis and purification

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00118A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Vikas Sharma, Amirreza Mottafegh, Jeong-Un Joo, Dong-Pyo Kim
Automated end-to-end microfluidic mRNA production integrates oscillatory IVT with biocatalytic DNase membrane assisted μ-TFF and sensor-guided multimodal chromatography, delivering higher yield, reduced dsRNA and rapid synthesis-to-purification.
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Microparticle-enabled single cell multiparameter electronic immunophenotyping for selective electroporation

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00180G, Paper

Madeline Hoyle, Josiah Rudge, Yuvraj Rallipalli, Aniruddh Sarkar
Detection of multifrequency impedance signatures of microparticle labeled single cells in a 3D printed microfluidic channel enables real time selective electroporation of cell subpopulations for cell engineering.
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A 3D-printed electromagnetically actuated microgripper system for precision single-cell manipulation

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00081A, Paper

Xi Chen, Qingying Ren, Wenshuo Zhao, Minhao Wang, Yining Guo, Jing Huang, Xuhui Zhao, Xinyu Lu, Yuan Liu, Haifeng Xu
A 3D-printed electromagnetic microgripper enabling controllable single-cell manipulation with stable actuation and a liquid-retention structure.
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Facile fabrication of high-density two-dimensional micronozzle arrays using twisted thin-wire molds

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00036C, Paper

Koki Takahashi, Kyohei Terao
Rotational skewing of thin-wire arrays enables simple fabrication of dense micronozzle arrays with independently connected channels, allowing localized hydrodynamic flow confinement and microscale liquid processing.
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Highly Sensitive Wireless Dual-Spiral Resonant Contact Lens for Continuous Intraocular Pressure Monitoring

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC00940E, Paper

Ying Liu, Zhixian Chen, Xiaoyu Zhao, Lin Xu, Shengli Mi
Continuous and non-invasive intraocular pressure (IOP) monitoring is crucial for managing glaucoma, a leading cause of irreversible blindness worldwide. However, existing tonometry methods are intermittent and lack the capability to...
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Numerical microfluidic chip modeling of laminar vortex dynamics induced by biomineralization in evolving porous media

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01002K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yajie Chu, Dianlei Feng
A 3D numerical microfluidic chip reveals the evolution of precipitation, vortices, and mixing during biomineralization. Precipitate alters pore geometry, inducing vortices that impact mixing.
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Bioinspired quality-based sperm sorting in a spiral microfilter-enhanced microfluidic device: enhancing DNA integrity via rheotaxis and boundary dynamics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00427F, Paper

Donya Shahhoseini, Naser Naserifar
A bioinspired spiral microfluidic device leverages rheotaxis and boundary dynamics for label-free sperm sorting, reducing DNA fragmentation and enhancing viability, providing a practical solution for challenging semen in assisted reproduction.
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Band-stop microfluidics for high-purity, label-free enrichment of viable cancer cells from whole blood

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00039H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lewis Krzeczkowski, Georgios Nteliopoulos, Simak Ali, Paul Davey, R. Charles Coombes, Ali Salehi-Reyhani
A microfluidic band-stop filter selectively enriches viable CTC-sized cells from undiluted whole blood while excluding smaller and larger blood cells. Captured cells remain viable, can be drug-tested on-chip, and recovered off-chip.
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Robotic acoustofluidic single-cell picking and placement platform

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01129A, Paper

Wanqi Li, Qiu Yin, Jiahui Wu, Chenfan Zhang, Xiaochen Li, Chenyang Zhou, Xianting Ding, Xiang Chen
Single-cell manipulation is essential for investigating cellular heterogeneity and enabling downstream assays, such as single-cell proteomics and drug screening.
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High-speed liquid switching and on-chip force sensing reveal the transient mechanical response of MscL in Synechocystis sp. PCC 6803

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00004E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xu Du, Masaru Tsujii, Nobuyuki Uozumi, Fumihito Arai
High-speed liquid switching with on-chip force sensing enables millisecond extracellular regulation and quantification of the transient mechanical response of a single cell during osmotic stimulation.
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An automated and portable platform for rapid cell-free DNA isolation and its application in microbial DNA metagenomic sequencing from human blood samples

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00876J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Linda Marriott, Ana Martinez-Lopez, Antonio Liga, Kazuhiro Horiba, Amanda Warr, Jacob N. Phulusa, Radhe Shantha Kumar, Laura Carey, Yoshinori Ito, Benjamin J. Parcell, Nicholas R. Leslie, Nicholas A. Feasey, Shevin T. Jacob, Jamie Rylance, Maïwenn Kersaudy-Kerhoas
CNASafe, a portable automated platform, rapidly isolates plasma cfDNA with yields comparable to standard kits, enabling real-time nanopore sequencing and detection of pathogens missed by blood culture within hours.
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Cap-Sweat: a capillary microfluidic platform for digitized sweat sampling and time-resolved biomarker analysis

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01172H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pezhman Jalali, Amir Sanati Nezhad
Wearable capillary device for time-resolved sweat analysis.
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Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01063B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ling Ding, Huizi Zhang, Yao Li, Jun Kameoka
A stitched lyocell–modal microfluidic platform guides saliva to a microneedle-based electrochemical sensor, providing a simple route for low-concentration lactate detection in human saliva.
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A dual-antibody gold nanoparticle-based lateral flow assay for rapid and selective detection of mesenchymal stem cell stemness

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00037A, Paper

Drishya Prakashan, C. A. Amarnath, Shilpa N. Sawant, G. Taru Sharma, Sonu Gandhi
Smartphone readable AuNPs-LFA enables rapid, visual, and qualitative detection of stemness of MSCs.
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A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01171J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Delaney Gray-Scherr, Terry Ching, Katherine Beran, Sarah C. Adams, Emily Davis, Abraham C. I. van Steen, Trisha Raman, Wilson W. Wong, Jeroen Eyckmans, Christopher S. Chen
A 3D microfluidic platform for studying cross-network transport and trafficking interactions between independently perfusable blood and lymphatic microvascular networks.
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