RSC - Lab Chip latest articles

Direct-Writing Colloidal Photonic Crystal Microfluidic Chips by Inkjet Printing for Label-Free Protein Detection

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40311K, Paper

Weizhi Shen, Mingzhu Li, Changqing Ye, Lei Jiang, Yanlin Song
Integrating photonic crystal (PC) into the microfluidic system has attracted immense interest for its novel functions. However, it is still a great challenge to fabricate PC microfluidic chip rapidly with...
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Programmable large area digital microfluidic array with integrated droplet sensing for bioassays

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40273D, Paper

Hywel Morgan, Ben Hadwen, Graham Broder, Diego Morganti, Adrian Jacobs, Campbell Brown, Yasushi Kubota, Jason Hector
We describe a new device concept for digital microfluidics, based on Active Matrix Electrowetting on Dielectric (AM-EWOD). A conventional EWOD device is limited by the number of electrical connections that...
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Electro-Optical BLM Chips Enabling Dynamic Imaging of Ordered Lipid Domains

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40077D, Paper

Chenren Shao, Eric L Kendall, Don DeVoe
Studies of lipid rafts, ordered microdomains of sphingolipids and cholesterol within cell membranes, are essential in probing the relationships between membrane organization and cellular function. While in vitro studies of...
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Wafer-scale mitochondrial membrane potential assays

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40086C, Paper

Tae-Sun Lim, Antonio Davila Jr, Katayoun Zand, Douglas C. Wallace, Peter J. Burke
We present a novel technique for wafer-scale fabrication of devices to measure mitochondrial membrane potential in a microfluidic environment.
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A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40236J, Paper

Robert Meissner, Pierre Joris, Bilge Eker, Arnaud Bertsch, Philippe Renaud
We present a novel technology for the simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair.
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A microfluidic "baby machine" for cell synchronization

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40277G, Paper

Josephine Shaw, Kristofor Payer, Sungmin Son, William H. Grover, Scott R. Manalis
The microfluidic "baby machine" holds mammalian cells onto a surface solely by pressure differences, and elutes newborn cells in G1.
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Controllable Microfluidic production of Gas-in-Oil-in-Water emulsions for hollow microspheres with thin polymer shells

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40387K, Communication

Ran Chen, Pengfei Dong, Jianhong Xu, Yundong Wang, Guangshen Luo
Here we developed a simple and novel one-step approach to produce G/O/W emulsions with high gas volume fractions in a capillary microfluidic device. The thickness of the oil layer can...
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Electrokinetically tunable optofluidic bi-concave lens

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40406K, Paper

Haiwang Li, Chaolong Song, Trung Dung Luong, Nam-Trung Nguyen, Teck Neng Wong
This paper numerically and experimentally investigates and demonstrates the design of an optofluidic in-plane bi-concave lens to perform both light focusing and diverging using the combined effect of pressure driven...
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Real-time monitoring of strand-displacement DNA amplification by a contactless electrochemical microsystem using interdigitated electrodes

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40384F, Paper

Xinxin Fang, Huanqian Zhang, Feng Zhang, Fengxiang Jing, Hongju Mao, Qing-Hui Jin, Jianlong Zhao
This paper reports the design and implementation of a contactless conductivity detection system which combines a thermal control cell, a data processing system and an electrochemical (EC) cell, for label-free...
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In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40131B, Paper

Noo Li Jeon
This paper describes the in-vitro formation and characterization of perfusable capillary network made of HUVECs in microfluidic devices (MFDs). Using this platform, array of 3D tubular capillary of various dimensions...
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Nanoporous micro-element arrays for particle interception in microfluidic cell separation

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40109F, Paper

Grace D. Chen, Fabio Fachin, Elena Colombini, Brian Wardle, Mehmet Toner
The ability to control cell-surface interactions in order to achieve binding of specific cell types is a major challenge for microfluidic immunoaffinity cell capture systems. In the majority of existing...
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A Minimally Invasive Microchip for Transdermal Injection/Sampling Applications

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40348J, Paper

Lucanos M Strambini, Angela Longo, Alessandro Diligenti, Giuseppe Barillaro
Design, fabrication, and characterization of minimally invasive silicon microchip for transdermal injection/sampling applications is reported and discussed. The microchip integrates an array of silicon-dioxide hollow microneedles with lateral size of...
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Aptamer-Based Silver Nanosensor for Multiple Protein Detection

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40322F, Paper

Ying Wang, Danke Xu, Hong-Yuan Chen
In the present work, we design a novel aptamer-based silver nanosensor for one-spot simultaneously detection of multiple proteins. SS-DNA modified AgNPs were immobilized on the aldehyde coated glass slide to...
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Controlled Synthesis of Fluorescent Silica Nanoparticles inside Microfluidic Droplets

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40300E, Paper

Josias B. Wacker, Ioannis Lignos, Virendra Kumar Parashar, Martin Gijs
We study the droplet-based synthesis of fluorescent silica nanoparticles (50-350 nm size) in a microfluidic chip. Fluorescein-isothiocyanate (FITC) dye is first chemically linked to aminopropyl triethoxysilane (APTES) in ethanol and...
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Targeted delivery to single cells in precisely controlled microenvironments

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40216E, Paper

John M. Collins, Ruby T.S. Lam, Ziping Yang, Bita Semsarieh, Alexander B. Smetana, Saju Nettikadan
Tip-based lithography for precision, multiplexed patterning. Fabrication of cellular microenvironment arrays used for targeted delivery to single or few cells.
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Single channel layer, single sheath-flow inlet microfluidic flow cytometer with three-dimensional hydrodynamic focusing

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40246G, Paper

Shiang-Chi Lin, Pei-Wen Yen, Chien-Chung Peng, Yi-Chung Tung
Flow cytometry is a technique capable of optically characterizing biological particles in a high-throughput manner. In flow cytometry, three dimensional (3D) hydrodynamic focusing is critical for accurate and consistent measurement....
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Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21285D, Communication

Sewoon Han, Kisuk Yang, Yoojin Shin, Jung Seung Lee, Roger D. Kamm, Seok Chung, Seung-Woo Cho
Here, we report a unique method to quantify the effects of in vivo-like extracellular matrix (ECM) for guiding differentiation of neural stem cells (NSCs) in three-dimensional (3D) microenvironments using quantitative real-time polymerase chain reaction (qRT-PCR).
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Cell-free protein synthesis from a single copy of DNA in a glass microchamber

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40098G, Paper

Taiji Okano, Tomoaki Matsuura, Yasuaki Kazuta, Hiroaki Suzuki, Tetsuya Yomo
Glass and PDMS hybrid microchambers were fabricated to conduct protein synthesis from a single copy of DNA using the in vitro transcription and translation system.
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Microfluidic micropipette aspiration for measuring the deformability of single cells

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40205J, Paper

Quan Guo, Sunyoung Park, Hongshen Ma
Microfluidic device for measuring the deformability of single cells using threshold deformation pressure through micro-scale constrictions similar to micropipette aspiration.
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A multi-shear perfusion bioreactor for investigating shear stress effects in endothelial cell constructs

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40144D, Paper

Menahem Y. Rotenberg, Emil Ruvinov, Anna Armoza, Smadar Cohen
Micro-fabricated multi-shear perfusion bioreactor able to deliver six different levels of shear stresses (1-13 dyne cm^-2) to six constructs simultaneously, during a single run, induces different lengths of HUVEC cell sprouts.
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Research highlights

Lab Chip, 2012, 12,2094-2096
DOI: 10.1039/C2LC90054H, Highlight

Seila Selimovic, Cole A. DeForest, Mehmet R. Dokmeci, Ali Khademhosseini
Predicting localized ligand-based cell signaling - Anisotropic supraparticles generated using microfluidics - Microfluidics for micro-immunohistochemistry.
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Interaction-free, automatic, on-chip fluid routing by surface acoustic waves

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40396J, Communication

Marco Travagliati, Giorgio De Simoni, Carlo Maria Lazzarini, Vincenzo Piazza, Fabio Beltram, Marco Cecchini
By exploiting the resonant coupling between a travelling wave and the stationary modes of a cavity, we present the first scheme for integrated automatic interaction-free surface acoustic wave routing of...
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Engineering and Analysis of Surface Interactions in a Microfluidic Herringbone Micromixer

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40356K, Technical Innovation

Thomas P Forbes, Jason Kralj
We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices...
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Engineering the surface properties of microfluidic stickers

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40284J, Technical Innovation

Bertrand Levache, Ammar Azioune, Maurice Bourrel, Vincent Studer, Denis Bartolo
We introduce a simple and effective method to tailor the wetting, and the adhesion, properties of microfluidic stickers. This one-step lithographic scheme combines most of the advantages offered by the...
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Ultra-rapid laser protein micropatterning: screening for directed polarization of single neurons

Lab Chip, 2012, 12,2265-2276
DOI: 10.1039/C2LC21105J, Paper

Mark A. Scott, Zachary D. Wissner-Gross, Mehmet Fatih Yanik
We present a rapid laser protein-micropatterning method using multi-photon photobleaching of fluorophores, and direct the polarization of single neurons using triangle ratchets.
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Integrated rapid-diagnostic-test reader platform on a cellphone

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40235A, Paper

Onur Mudanyali, Stoyan Dimitrov, Uzair Sikora, Swati Padmanabhan, Isa Navruz, Aydogan Ozcan
We demonstrate a cellphone-based rapid-diagnostic-test reader platform that can work with various types of lateral flow immuno-chromatographic assay to sense the presence of a target analyte in a sample.
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Recent progress in the design of nanofiber-based biosensing devices

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21240D, Critical Review

Lauren Matlock-Colangelo, Antje J. Baeumner
This review discusses the nanofiber materials used to increase functional surface area and improve sensitivity of analyte detection within biosensors.
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Ion diode logics for pH control

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40093F, Paper

Erik O. Gabrielsson, Klas Tybrandt, Magnus Berggren
Micro-fabricated ion diodes based on bipolar membranes showing low hysteresis are used as components in a ionic circuit for pH control.
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Polyethyleneimine coating renders polycarbonate resistant to organic solvents

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21297H, Paper

Pawel Jankowski, Dominika Ogonczyk, Wojciech Lisowski, Piotr Garstecki
Polyethyleneimine coating of polycarbonate microfluidic chips allows for handling of organic reactions in toluene, benzene, acetonitrile, tetrahydrofuran, dioxane, acetone, THF, ethyl acetate and ethylene dichloride.
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Contributors to the USA issue

Lab Chip, 2012, 12,2091-2093
DOI: 10.1039/C2LC90053J, Profile

Lab on a Chip profiles the contributors to the USA issue.
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Lab on a Chip: United States of America

Lab Chip, 2012, 12,2089-2090
DOI: 10.1039/C2LC90052A, Editorial

Donald E. Ingber, George M. Whitesides
The Wyss Institute Symposium on "Microfluidics and Medicine: Accelerating the Flow from Lab to the Clinic", which inspired this issue, focused on work in the microfluidics field that promises to have a transformative impact on medicine and clinical care.
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A ternary model for double-emulsion formation in a capillary microfluidic device

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21235H, Paper

Jang Min Park, Patrick D. Anderson
A ternary diffuse-interface model is presented to predict double-emulsion formation in a capillary microfluidic device.
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Induced hydrophobic recovery of oxygen plasma-treated surfaces

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21052E, Technical Innovation

David J. Guckenberger, Erwin Berthier, Edmond W. K. Young, David J. Beebe
We describe a practical and cheap technique to induce hydrophobic recovery of plasma-treated surfaces that can be easily adopted by any lab with access to common lab supplies such as tapes and wipers.
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Isothermal nucleic acid amplification technologies for point-of-care diagnostics: a critical review

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40100B, Critical Review

Pascal Craw, Wamadeva Balachandran
An up-to-date review of existing isothermal nucleic acid amplification technologies and their implementation in point-of-care diagnostic instrumentation.
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High Throughput Method for Prototyping Three-Dimensional, Paper-Based Microfluidic Devices

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40331E, Technical Innovation

Gregory G Lewis, Matthew J DiTucci, Matthew S Baker, Scott Phillips
This paper describes an efficient and high throughput method for fabricating three-dimensional (3D) paper-based microfluidic devices. The method avoids tedious alignment and assembly steps and eliminates a major bottleneck that...
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Thermoplastic fusion bonding using a pressure-assisted boiling point control system

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40252A, Technical Innovation

Taehyun Park, In-Hyouk Song, Daniel S. Park, Byoung Hee You, Michael C. Murphy
One of critical steps in manufacturing polymer microfluidic devices is the sealing process used to obtain closed structures containing microchannels. A novel thermoplastic fusion bonding method using a pressure-assisted boiling...
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Biocompatible "Click" Wafer Bonding for Microfluidic Devices

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21098C, Technical Innovation

Farizah Saharil, Carl Fredrik Carlborg, Tommy Haraldsson, Wouter Wouter van der Wijngaart
We introduce a novel dry wafer bonding concept designed for permanent attachment of micromolded polymer structures to chemically functionalized silicon substrates. The method, designed for simultaneous fabrication of many lab-on-chip...
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Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40114B, Paper

melania paturzo, andrea finizio, PASQUALE MEMMOLO, Roberto Puglisi, Donatella Balduzzi, Andrea Galli, Pietro Ferraro
We show that sharp imaging and quantitative phase-contrast microcopy is possible in microfluidics in flowing turbid media by digital holography. In fact, in flowing liquids with suspended colloidal particles, clear...
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Lab-in-a-Tube: on-chip integration of glass optofluidic ring resonators for label-free sensing applications

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40275K, Paper

Stefan M Harazim, Vladimir A. Bolanos Quinones, Suwit Kiravittaya, Samuel Sanchez, Oliver Schmidt
The fabrication of tubular rolled-up optofluidic ring resonators (RU-OFRRs) based on glass (SiO2) material with high quality factors is reported. A novel methodology combining lab-on-a-chip fabrication methods and rolled-up nanotech...
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Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40213K, Paper

Javier Ramon, Samad Ahadian, Raquel Obregon, Gulden Camci-Unal, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue
Establishing the 3D microscale organization of cells has numerous practical applications, such as in determining cell fate (e.g., proliferation, migration, differentiation, and apoptosis) and in making functional tissue constructs. One...
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Inverted open microwells for cell trapping, cell aggregate formation and parallel recovery of live cells

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40124J, Paper

Massimo Bocchi, Laura Rambelli, Andrea Faenza, Luca Giulianelli, Nicola Pecorari, Enri Duqi, Jean-Charles Gallois, Roberto Guerrieri
The inverted open microwell is a novel microstructure supporting isolation of single cells, analysis of cell-cell and cell-molecule interactions and functional cell sorting. This work introduces the inverted open microwell...
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Nanowire-integrated microfluidic devices for facile and reagent-free mechanical cell lysis

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40154A, Paper

Jung Kim, Jung Woo Hong, Dong-Pyo Kim, Jennifer H Shin, Inkyu Park
Cell lysis is an essential task for the diagnosis of intracellular components. In this work, we introduce novel microfluidic devices integrated with patterned one-dimensional nanostructure arrays for the facile and...
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Continuous operation of a hybrid solid-liquid state reconfigurable photonic system without resupply of liquids

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40191F, Paper

Erica Eunjung Jung, David Erickson
This paper describes an optofluidically reconfigurable photonic system without the need for continuous resupply of liquids during the operation.
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Microfluidic synthesis of multifunctional Janus particles for biomedical applications

Lab Chip, 2012, 12,2097-2102
DOI: 10.1039/C2LC90046G, Focus

Shikuan Yang, Feng Guo, Brian Kiraly, Xiaole Mao, Mengqian Lu, Kam W. Leong, Tony Jun Huang
Tony Jun Huang and co-workers discuss microfluidic synthesis of multifunctional Janus particles for biomedical applications - Part of a series of Focus articles elucidating bio-related issues that impact on lab on a chip and microfluidic research.
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High-throughput biophysical measurement of human red blood cells

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21210B, Paper

Yi Zheng, Ehsan Shojaei-Baghini, Azar Azad, Chen Wang, Yu Sun
This paper describes a microfluidic system for biophysically characterizing and classifying human RBCs at a speed of [similar]120 cells s^-1.
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A facile route for the fabrication of large-scale gate-all-around nanofluidic field-effect transistors with low leakage current

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40112F, Paper

Sangwoo Shin, Beom Seok Kim, Jiwoon Song, Hwanseong Lee, Hyung Hee Cho
We report a rapid, cost-effective route for the fabrication of large-scale nanofluidic field-effect transistors using a simple, lithography-free two-step fabrication process that consists of sputtering and barrier-type anodization.
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Sucrose-based fabrication of 3D-networked, cylindrical microfluidic channel for rapid-prototyping of lab-on-a-chip and vaso-mimetic device

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40267J, Technical Innovation

Jiwon Lee, Jungwook Paek, Jaeyoun Kim
We present a new fabrication scheme for 3D-networked, cylindrical microfluidic (MF) channels based on shaping, bonding, and assembly of sucrose fibers. It is a simple, cleanroom-free, and environment-friendly method ideal...
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Oxygenation by a superhydrophobic slip G/L contactor

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC21296J, Paper

Elif Karatay, Rob Lammertink
The compelling need for efficient supply of gases into liquids or degassing of fluids within confined microchannels triggered our study on membrane assisted microchemical systems. Microporous, hydrophobic, flat/micro-structured polyvinylidene fluoride...
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Heterotypic Cell Pair Co-culturing on Patterned Microarrays

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40349H, Paper

Edward James Felton, Craig R Copeland, Christopher S. Chen, Daniel Henry Reich
We present a pair-wise co-culturing technique that creates large numbers of heterotypic cell pairs in patterned arrays. Lithographic patterning produces arrays with thousands of traps, each designed to accommodate only...
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A Compact Optofluidic Cytometer with Integrated Liquid-core/PDMS-cladding Waveguides

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40329C, Paper

Peng Fei, Zitian Chen, Yongfan Men, Ang Li, Yiran Shen, Yanyi Huang
We developed a simple method to construct liquid-core/PDMS-cladding optical waveguides through pressurized filling of dead-ended micro-channels with optical fluids. The waveguides are in the same layer as microfluidic channels which...
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Microfabricated Ratchet Structure Integrated Concentrator Arrays for Synthetic Bacterial Cell-to-Cell Communication Assays

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40294G, Paper

Taesung Kim
We describe a microfluidic concentrator array device that is integrated with microfabricated ratchet structures to concentrate motile bacterial cells in desired destinations with required cell densities. Since the device consists...
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SSA-MOA: A Novel CTC Isolation Platform Using Selective Size Amplification (SSA) and a Multi-Obstacle Architecture (MOA) Filter

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40065K, Paper

Minseok S Kim, Tae Seok Sim, Yeon Jeong Kim, Sun Soo Kim, Hyoyoung Jeong, Jong-Myeon Park, Hui-Sung Moon, Seung-Il Kim, Ogan Gurel, Soo Suk Lee, Jeong Gun Lee, Jae Chan Park
Circulating tumor cells (CTCs) have gained increasing attention as physicians and scientists learn more about the role of these extraordinarily rare cells in metastatic cancer. In developing CTC technology, the...
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UV epoxy bonding for enhanced SAW transmission and microscale acoustofluidic integration

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40085E, Method

Sean Langelier, Leslie Yeo, James R. Friend
Surface acoustic waves (SAWs) are appealing as a means to manipulate fluids within lab-on-a-chip systems. However, current acoustofluidic devices almost universally rely on elastomeric materials, especially PDMS, that are inherently...
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Digital Microfluidics: A Versatile Tool For Applications in Chemistry, Biology and Medicine

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40318H, Critical Review

Mais J. Jebrail, Michael S. Bartsch, Kamlesh D Patel
Digital microfluidics (DMF) has recently emerged as a popular technology for a wide range of applications. In DMF, nanoliter to microliter droplets containing samples and reagents can be manipulated to...
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On-chip electroporation, membrane repair dynamics and transient in-cell recordings by arrays of gold mushroom-shaped microelectrodes

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40091J, Paper

Aviad Hai, Micha E Spira
The study demonstrates the use of on-chip gold mushroom-shaped microelectrodes (gM[small micro]Es) to generate localized electropores in the plasma membrane of adhering cultured neurons and to electrophysiologically monitor the ensuing membrane...
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Fluorinated liquid-enabled protein handling and surfactant-aided crystallization for fully in situ digital microfluidic MALDI-MS analysis

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21135A, Paper

Andrew P. Aijian, Debalina Chatterjee, Robin L. Garrell
Complete in situ peptide mass fingerprinting is performed on a digital microfluidic device using fluorinated liquid encapsulation to facilitate movement of the protein droplet and a fluorinated surfactant (PFOA) to enhance matrix co-crystallization and MALDI-MS spectral quality.
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Concurrent recordings of bladder afferents from multiple nerves using a microfabricated PDMS microchannel electrode array

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21277C, Paper

Evangelos Delivopoulos, Daniel J. Chew, Ivan R. Minev, James W. Fawcett, Stephanie P. Lacour
We present a compliant neural interface to record bladder afferent activity from L6 and S1 dorsal rootlets of an anaesthitized rat.
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Control of the length of microfibers

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40280G, Communication

Janine K. Nunes, Krzysztof Sadlej, Jee Ian Tam, Howard A. Stone
We developed a simple microfluidic method for synthesizing polymeric microfibers, where the fiber length can be systematically varied as a function of valve frequency.
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In vitro and in vivo testing of glucose-responsive insulin-delivery microdevices in diabetic rats

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40139H, Paper

Michael K. L. Chu, Jian Chen, Claudia R. Gordijo, Simon Chiang, Alexander Ivovic, Khajag Koulajian, Adria Giacca, Xiao Yu Wu, Yu Sun
We have developed an implantable, glucose-responsive microdevice that shows rapid in vitro and in vivo efficacy in a diabetic rat model.
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Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40130D, Technical Innovation

Colette A. Bichsel, Samy Gobaa, Stefan Kobel, Chiara Secondini, George N. Thalmann, Marco G. Cecchini, Matthias P. Lutolf
Microfluidic immunocapture of circulating tumor cells was merged with three-dimensional (3D) cell culture on the same chip to assess clonal 3D spheroid growth potential.
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High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation

Lab Chip, 2012, 12,2190-2198
DOI: 10.1039/C2LC21290K, Paper

Angela R. Wu, Tiara L.A. Kawahara, Nicole A. Rapicavoli, Jan van Riggelen, Emelyn H. Shroff, Liwen Xu, Dean W. Felsher, Howard Y. Chang, Stephen R. Quake
An automated microfluidic-based, high-throughput platform for chromatin immunoprecipitation screening that is sensitive enough to detect cytokine-induced cellular epigenetic changes over a fine temporal resolution.
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Enriching carbonylated proteins inside a microchip through the use of oxalyldihydrazide as a crosslinker

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40103G, Paper

Bryant C. Hollins, Steven A. Soper, June Feng
This report demonstrates the use of oxalyldihydrazide as a novel crosslinker for enrichment of carbonylated proteins inside a disposable, polymeric microfluidic device.
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Single-Step Multiplex Detection of Toxic Metal Ions by Au Nanowires-on-Chip Sensor Using Reporter Elimination

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40185A, Paper

Taejoon Kang, Seung Min Yoo, Mijeong Kang, Hyoban Lee, Hongki Kim, Sang Yup Lee, Bongsoo Kim
We have developed Au nanowires (NWs)-on-chip surface-enhanced Raman scattering (SERS) multiplex sensor that can sensitively detect multiple toxic metal ions. Most importantly, reporter elimination method simplified the detection procedure to...
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Acoustofluidics 12: Biocompatibility and cell viability in microfluidic acoustic resonators

Lab Chip, 2012, 12,2018-2028
DOI: 10.1039/C2LC40201G, Focus

Martin Wiklund
In this focus article we discuss the factors defining the biocompatibility of a micro-device for ultrasonic cell manipulation, and different methods to measure cell viability.
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Microengineered physiological biomimicry: Organs-on-Chips

Lab Chip, 2012, 12,2156-2164
DOI: 10.1039/C2LC40089H, Frontier

Dongeun Huh, Yu-suke Torisawa, Geraldine A. Hamilton, Hyun Jung Kim, Donald E. Ingber
Microscale engineering technologies provide unprecedented opportunities to create cell culture microenvironments that go beyond current three-dimensional in vitro models by recapitulating the critical tissue-tissue interfaces, spatiotemporal chemical gradients, and dynamic mechanical microenvironments of living organs.
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Microfluidic Apps for off-the-shelf instruments

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC00043A, Critical Review

Daniel Mark, Felix von Stetten, Roland Zengerle
This article promotes the idea of "Microfluidic Apps"; microfluidic chips that are designed to extend the functionality of existing instruments.
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Thermal analysis of nanofluids in microfluidics using an infrared camera

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40222J, Paper

Pyshar Yi, Aminuddin A. Kayani, Adam F. Chrimes, Kamran Ghorbani, Saeid Nahavandi, Kourosh Kalantar-zadeh, Khashayar Khoshmanesh
We present the thermal analysis of liquid containing Al₂O₃ nanoparticles in a microfluidic platform using an infrared camera.
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Optimized preparation of pDNA/poly(ethylene imine) polyplexes using a microfluidic system

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40176B, Paper

Heiko Debus, Moritz Beck-Broichsitter, Thomas Kissel
A microfluidic method for polyplex formation with poly(ethylene imine) and nucleic acids was compared with the standard pipetting method.
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Proteolysis in microfluidic droplets: an approach to interface protein separation and peptide mass spectrometry

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40206H, Communication

Ji Ji, Lei Nie, Liang Qiao, Yixin Li, Liping Guo, Baohong Liu, Pengyuan Yang, Hubert H Girault
A versatile microreactor protocol based on microfluidic droplets has been developed for on-line protein digestion. Proteins separated by liquid chromatography are fractionated in water-in-oil droplets and digested in sequence. The...
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Microfluidic Very Large Scale Integration (mVLSI) with Integrated Micromechanical Valves

Lab Chip, 2012, Accepted Manuscript
DOI: 10.1039/C2LC40258K, Technical Innovation

Ismail Emre Araci, Stephen Quake
Microfluidic chips with a high density of control elements are required to improve device performance parameters such as throughput, sensitivity and dynamic range. In order to realize robust and accessible...
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Research highlights

Lab Chip, 2012, 12,2015-2017
DOI: 10.1039/C2LC90045A, Highlight

Seila Selimovic, Cole A. DeForest, Mehmet R. Dokmeci, Ali Khademhosseini
Hydrodynamic tweezers - Combinatorial concentration gradients for drug screening - Culturing endothelial cells on micropillars.
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High-throughput immunoassay through in-channel microfluidic patterning

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40145B, Communication

Chunhong Zheng, Jingwen Wang, Yuhong Pang, Jianbin Wang, Wenbin Li, Zigang Ge, Yanyi Huang
Pneumatic button valves enable surface patterning inside microfluidic channels and facilitate highly sensitive and robust immunoassays.
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Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21012F, Paper

Waseem Asghar, Yuan Wan, Azhar Ilyas, Robert Bachoo, Young-tae Kim, Samir M. Iqbal
We present a solid-state micropore based device that can differentiate cancer cells from whole blood with more than 85% detection efficiency.
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Ion channel drug potency assay with an artificial bilayer chip

Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40087A, Paper

Ahmad M. El-Arabi, Carl S. Salazar, Jacob J. Schmidt
We present an automation and array compatible artificial bilayer chip and its use for measurements of drug potency on the TRPM8 ion channel.
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Analytical miniaturization and nanotechnologies

Lab Chip, 2012, 12,1915-1916
DOI: 10.1039/C2LC90040H, Editorial

Arben Merkoci, Jorg P. Kutter
This Lab on a Chip themed issue is in collaboration with the III International Workshop on Analytical Miniaturization and NANOtechnologies, Barcelona, 2012.
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