RSC - RSC Med. Chem. latest articleshttp://pubs.rsc.org/en/Journals/Journal/MDRSC - RSC Med. Chem. latest articlesCopyright (c) The Royal Society of ChemistryMon, 11 Mar 2024 14:34:31 ZRSC - RSC Med. Chem. latest articleshttp://pubs.rsc.org/content/NewImages/rsc_publishing_logo.gifRSC - RSC Med. Chem. latest articleshttp://pubs.rsc.org/en/Journals/Journal/MDhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00015Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00015CDesign and Synthesis of Meldrum’s acid Based 7-Azaindole Anchored 1,2,3-Triazole Hybrids as Anticancer Agents<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00015C, Research Article</div><div>Muralikrishna Vanga, Rambabu Bhukya, Vishnu Thumma, S S S S Sudha Ambadipudi, Lakshma V. Nayak, SAI BALAJI ANDUGULAPATI, vijjulatha manga<br/>A series of Meldrum’s acid, 7-azaindole and 1,2,3-triazole hybrids were synthesized and evaluated for their anticancer activity in five different cancer cell lines i.e.: MCF-7 (breast cancer), HeLa (cervical cancer),...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-11T00:00:00ZMuralikrishna VangaRambabu BhukyaVishnu ThummaS S S S Sudha AmbadipudiLakshma V. NayakSAI BALAJI ANDUGULAPATIvijjulatha mangahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00674Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00674CThe medicinal chemistry evolution of antibody–drug conjugates<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00674C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00674C, Review Article</div><div>Adrian D. Hobson<br/>For an optimal ADC the symbiotic relationship of the three structurally disparate components requires they all function in unison and medicinal chemistry has a huge role to enable this.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZAdrian D. Hobsonhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00719Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00719GDeconvoluting low yield from weak potency in direct-to-biology workflows with machine learning<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00719G" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00719G, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>William McCorkindale, Mihajlo Filep, Nir London, Alpha A. Lee, Emma King-Smith<br/>Augmenting direct-to-biology workflows with a new machine learning framework.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-15T00:00:00ZWilliam McCorkindaleMihajlo FilepNir LondonAlpha A. LeeEmma King-Smithhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00752Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00752AAptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00752A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00752A, Research Article</div><div>Yuejie Zhu, Xiang Li, Qi Zhang, Xiantao Yang, Xudong Sun, Yi Pan, Xia Yuan, Yuan Ma, Bo Xu, Zhenjun Yang<br/>Encapsulated by cytidinyl lipid, G-quadruplex based aptamer AS1411 <em>etc.</em> entered nucleus and targeted to KRAS promoter/hnRNP A1 complex, showed higher activity against drug-resistant lung cancer.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-04T00:00:00ZYuejie ZhuXiang LiQi ZhangXiantao YangXudong SunYi PanXia YuanYuan MaBo XuZhenjun Yanghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00017Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00017JSynthesis and structure–activity relationship of novel thiazole aminoguanidines against MRSA and Escherichia coli<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00017J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00017J, Research Article</div><div>Ping Yang, Hui-Zhong Liu, Ying-Si Wang, Hong Qi, Ling-Ling Wang, Bei-Bei Wang, Xiao-Bao Xie<br/>Increasing molecular flexibility improves the performance of thiazole aminoguanidines against drug-resistant bacteria and Gram-negative bacteria.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-29T00:00:00ZPing YangHui-Zhong LiuYing-Si WangHong QiLing-Ling WangBei-Bei WangXiao-Bao Xiehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00600Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00600J2,3-Dihydroquinazolin-4(1H)-ones and Quinazolin-4(3H)-ones as Broad-Spectrum Cytotoxic Agents and Impact on Tubulin Polymerisation<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00600J, Research Article</div><div>Nicholas O'Brien, Jayne Gilbert, Adam McCluskey, Jennette Sakoff<br/>Tubulin plays a central role in mitosis and has been the target of multiple anticancer drugs, including paclitaxel. Herein two separate families of 2,3-dihydroquinazoline-4(1<em>H</em>)-ones and quinazoline-4(3<em>H</em>) ones, comprising 57 compounds...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-06T00:00:00ZNicholas O'BrienJayne GilbertAdam McCluskeyJennette Sakoffhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00043Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00043ASynthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D4MD00043A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD00043A, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Marthe Vandevelde, Andreas Simoens, Bavo Vandekerckhove, Christian Stevens<br/>Psilocybin analogues have been synthesized comprising a non-hydrolysable P–C bond to evaluate the biological activity and the selectivity towards 5-HT<small><sub>2A</sub></small>R, 5-HT<small><sub>2B</sub></small>R and the TNAP receptor.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-21T00:00:00ZMarthe VandeveldeAndreas SimoensBavo VandekerckhoveChristian Stevenshttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00633Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00633FChemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00633F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00633F, Research Article</div><div>Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Magdalena M. Szewczyk, Matthew F. Calabrese, Agustin Casimiro-Garcia, Subramanyam Chakrapani, Matthew S. Dowling, Emel Ficici, Jisun Lee, Justin I. Montgomery, Thomas N. O'Connell, Grzegorz J. Skrzypek, Tuan P. Tran, Matthew D. Troutman, Feng Wang, Jennifer A. Young, Jinrong Min, Dalia Barsyte-Lovejoy, Peter J. Brown, Vijayaratnam Santhakumar, Cheryl H. Arrowsmith, Masoud Vedadi, Dafydd R. Owen<br/>A chemical probe (PFI-7) for the Gid4 subunit of the human E3 ligase CTLH degradation complex.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-05T00:00:00ZAliakbar Khalili YazdiSumera PerveenCheng DongXiaosheng SongAiping DongMagdalena M. SzewczykMatthew F. CalabreseAgustin Casimiro-GarciaSubramanyam ChakrapaniMatthew S. DowlingEmel FiciciJisun LeeJustin I. MontgomeryThomas N. O'ConnellGrzegorz J. SkrzypekTuan P. TranMatthew D. TroutmanFeng WangJennifer A. YoungJinrong MinDalia Barsyte-LovejoyPeter J. BrownVijayaratnam SanthakumarCheryl H. ArrowsmithMasoud VedadiDafydd R. Owenhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00751Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00751KDesign and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00751K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00751K, Research Article</div><div>Norhan A. Abdelrahman, Ahmed A. Al-Karmalawy, Maiy Y. Jaballah, Galal Yahya, Marwa Sharaky, Khaled A. M. Abouzid<br/>Novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-06T00:00:00ZNorhan A. AbdelrahmanAhmed A. Al-KarmalawyMaiy Y. JaballahGalal YahyaMarwa SharakyKhaled A. M. Abouzidhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00655Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00655GProgress on Small-Molecule Inhibitors Targeting PD-L1<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00655G, Review Article</div><div>Jindan Xu, Yuanfang Kong, Pengbo Zhu, Mingyan Du, Xuan Liang, Yan Tong, Xiaofei Li, Chunhong Dong<br/>PD-L1 is a transmembrane protein overexpressed by tumor cells. It binds to PD-1 on the surface of T-cells, suppresses T-cell activity and hinders the immune response against cancer. Clinically, several...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-03-04T00:00:00ZJindan XuYuanfang KongPengbo ZhuMingyan DuXuan LiangYan TongXiaofei LiChunhong Donghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00708Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00708ADesign, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00708A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00708A, Research Article</div><div>Mihaela-Liliana Ţînţaş, Ludovic Peauger, Anaïs Barré, Cyril Papamicaël, Thierry Besson, Jana Sopkovà-de Oliveira Santos, Vincent Gembus, Vincent Levacher<br/>Promising multitargets ligands in Alzheimer's disease: sequential BuChE and DYRK1A/CLK1 kinases inhibition.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-20T00:00:00ZMihaela-Liliana ŢînţaşLudovic PeaugerAnaïs BarréCyril PapamicaëlThierry BessonJana Sopkovà-de Oliveira SantosVincent GembusVincent Levacherhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00602Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00602FApplication of tobramycin benzyl ether as an antibiotic adjuvant capable of sensitizing multidrug-resistant Gram-negative bacteria to rifampicin<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00602F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00602F, Research Article</div><div>Danzel Marie Ramirez, Shiv Dhiman, Ayan Mukherjee, Ruwani Wimalasekara, Frank Schweizer<br/>The emergence of aminoglycoside resistance has prompted the development of amphiphilic aminoglycoside derivatives which target bacterial membranes.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-16T00:00:00ZDanzel Marie RamirezShiv DhimanAyan MukherjeeRuwani WimalasekaraFrank Schweizerhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00713Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00713HA colorimetric assay adapted to fragment screening revealing aurones and chalcones as new arginase inhibitors.<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00713H, Research Article</div><div>Jason Muller, Luca Marchisio, Rym Attia, Andy Zedet, Robin Maradan, Maxence Vallet, Alison Aebischer, Dominique Harakat, François Sénéjoux, Christophe Ramseyer, Sarah Foley, Bruno Cardey, Corine Girard, Marc Pudlo<br/>Arginase, a difficult-to-target metalloenzyme, is implicated in a wide range of diseases, including cancer, infectious, and cardiovascular diseases. Despite the medical need, existing inhibitors have limited structural diversity, consisting predominantly...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZJason MullerLuca MarchisioRym AttiaAndy ZedetRobin MaradanMaxence ValletAlison AebischerDominique HarakatFrançois SénéjouxChristophe RamseyerSarah FoleyBruno CardeyCorine GirardMarc Pudlohttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00038Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00038BDesign, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00038B, Research Article</div><div>Xin-Xin Wang, Runjie Wang Wang, Hua-Long Ji, Xiao-Yu Liu, Nai-Yu Zhang, Kai-Ming Wang, Kai Chen, Ping-Ping Liu, ning meng, Cheng-Shi Jiang<br/>Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated cell death. It has been shown that high glucose (HG) could induce ferroptosis in vascular endothelial cells (VECs), consequently contributing to the...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZXin-Xin WangRunjie Wang WangHua-Long JiXiao-Yu LiuNai-Yu ZhangKai-Ming WangKai ChenPing-Ping Liuning mengCheng-Shi Jianghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00027Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00027GRecognition of arylmetylidene derivatives of imidazothiazolotriazinones as novel tubulin polymerization inhibitors<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00027G, Research Article</div><div>Alexei N. Izmest'ev, Elena Svirshchevskaya, Sergey Akopov, Angelina N. Kravchenko, Galina A. Gazieva<br/>Two series of arylmethylidene derivatives of imidazothiazolotriazinone differing in the structure of imidazothiazolotriazine fragment were synthesized and their antiproliferative activity and effect on tubulin polymerization were evaluated. Some of the...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZAlexei N. Izmest'evElena SvirshchevskayaSergey AkopovAngelina N. KravchenkoGalina A. Gazievahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00021Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD00021HNew azole derivatives linked to indole/indoline moieties com-bined with FLC against drug-resistant C. albicans<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D4MD00021H, Research Article</div><div>Yunhong Shen, Min Pan, Hui Gao, Yi Zhang, Ruirui Wang, Jun Li, Zewei Mao<br/>C. albicans is the most common fungal pathogen associated with human opportunistic infections, and invasive fungal infections caused by C. albicans are becoming increasingly serious. However, with the rising incidence...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-28T00:00:00ZYunhong ShenMin PanHui GaoYi ZhangRuirui WangJun LiZewei Maohttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00648Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00648DMolecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00648D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00648D, Research Article</div><div>Vajja Krishna Rao, Subarno Paul, Mitchell Gulkis, Zhihang Shen, Haritha Nair, Amandeep Singh, Chenglong Li, Arun K. Sharma, Melike Çağlayan, Chinmay Das, Biswajit Das, Chanakya N. Kundu, Satya Narayan, Sankar K. Guchhait<br/>In this study, a unique strategy of scaffold-hopping-based molecular editing of a bioactive agent <strong>NSC-666719</strong> was investigated, which led to the development of new benzodithiazinedioxide-guanidine based anticancer agents with Polβ inhibition.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-30T00:00:00ZVajja Krishna RaoSubarno PaulMitchell GulkisZhihang ShenHaritha NairAmandeep SinghChenglong LiArun K. SharmaMelike ÇağlayanChinmay DasBiswajit DasChanakya N. KunduSatya NarayanSankar K. Guchhaithttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00724Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00724CDesign, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00724C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00724C, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres<br/>The process by which researchers from all over the world can apply for projects using the EFSL poised to the ECBL at the EU-OPENSCREEN screening facilities and optimize the hits identified through our network of chemistry partners.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-12T00:00:00ZXavier JalencasHannes BergLudvik Olai EspelandSridhar SreeramuluFranziska KinnenChristian RichterCharis GeorgiouVladyslav YadrykhinskyEdgar SpeckerKristaps JaudzemsTanja MiletićRobert HarmelPhil GribbonHarald SchwalbeRuth BrenkAigars JirgensonsAndrea ZalianiJordi Mestreshttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00714Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00714FInhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00714F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00714F, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Anjie S. Bispat, Fernanda C. Cardoso, Md. Mahadhi Hasan, Yashad Dongol, Ricki Wilcox, Richard J. Lewis, Peter J. Duggan, Kellie L. Tuck<br/>A detailed SAR study led to two potent Ca<small><sub>V</sub></small>2.2 inhibitors, the sulfonamide derivatives 42 and 45, which showed high plasma stability, low toxicity, favourable CNS MPO scores (4.0–4.4), and strong potency.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-31T00:00:00ZAnjie S. BispatFernanda C. CardosoMd. Mahadhi HasanYashad DongolRicki WilcoxRichard J. LewisPeter J. DugganKellie L. Tuckhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00711Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00711ANitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00711A, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Joana Ribeiro, Nikoletta Szemerédib, Bruno M.F. Gonçalves, Gabriella Spengler, Carlos Alberto Mateus Afonso, Maria-José Umbelino Ferreira<br/>Multidrug resistance (MDR) remains a challenging issue in cancer treatment. Aiming at finding anticancer agents to overcome MDR, the triacetyl derivative (2) of the labdane diterpenoid lactone andrographolide (1) underwent...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-26T00:00:00ZJoana RibeiroNikoletta SzemerédibBruno M.F. GonçalvesGabriella SpenglerCarlos Alberto Mateus AfonsoMaria-José Umbelino Ferreirahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00645Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00645JIn vitro biological evaluation and in silico studies of linear diarylheptanoids from Curcuma aromatica Salisb. as urease inhibitors<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00645J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00645J, Research Article</div><div>Tho Huu Le, Dung Ngoc Phuong Ho, Hai Xuan Nguyen, Truong Nhat Van Do, Mai Thanh Thi Nguyen, Lam K. Huynh, Nhan Trung Nguyen<br/>This study reports nine new diarylheptanoids first isolated from the <em>Curcuma aromatica</em> Salisb., among which three are discovered for the first time, and two significantly inhibit urease, shedding light on its potential in treating gastric ulcers.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-16T00:00:00ZTho Huu LeDung Ngoc Phuong HoHai Xuan NguyenTruong Nhat Van DoMai Thanh Thi NguyenLam K. HuynhNhan Trung Nguyenhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00651Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00651DAiZynth impact on medicinal chemistry practice at AstraZeneca<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00651D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00651D, Opinion</div><div>Jason D. Shields, Rachel Howells, Gillian Lamont, Yin Leilei, Andrew Madin, Christopher E. Reimann, Hadi Rezaei, Tristan Reuillon, Bryony Smith, Clare Thomson, Yuting Zheng, Robert E. Ziegler<br/>The AI retrosynthesis tool AiZynth has made positive impacts on AstraZeneca drug discovery projects. This opinion provides some examples and discusses how AI retrosynthesis fits into pharmaceutical research.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-16T00:00:00ZJason D. ShieldsRachel HowellsGillian LamontYin LeileiAndrew MadinChristopher E. ReimannHadi RezaeiTristan ReuillonBryony SmithClare ThomsonYuting ZhengRobert E. Zieglerhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00604Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00604BDiscovery of a new pyrido[2,3-d]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00604B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00604B, Research Article</div><div>Fernanda A. Rosa, Davana S. Gonçalves, Karlos E. Pianoski, Michael J. V. da Silva, Franciele Q. Ames, Rafael P. Aguiar, Hélito Volpato, Danielle Lazarin-Bidóia, Celso V. Nakamura, Ciomar A. Bersani-Amado<br/>The new pyrido[2,3-<em>d</em>]pyridazine-2,8-dione <strong>7c</strong> showed potential anti-inflammatory activity as a COX-1/COX-2 dual inhibitor.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-08T00:00:00ZFernanda A. RosaDavana S. GonçalvesKarlos E. PianoskiMichael J. V. da SilvaFranciele Q. AmesRafael P. AguiarHélito VolpatoDanielle Lazarin-BidóiaCelso V. NakamuraCiomar A. Bersani-Amadohttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90009Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90009JCorrection: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties<div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D4MD90009J, Correction</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Adrian D. Hobson, Haizhong Zhu, Wei Qiu, Russell A. Judge, Kenton Longenecker<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-22T00:00:00ZAdrian D. HobsonHaizhong ZhuWei QiuRussell A. JudgeKenton Longeneckerhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00746Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00746D1,5-disubstituted Tetrazoles as PD-1/PD-L1 Antagonist<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00746D, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Robin van der Straat, Rosalie Draijer, Ewa Surmiak, Roberto Butera, Lenard Land, Katarzyna Magiera-Mularz, Bogdan Musielak, Jacek Plewka, Tad Holak, Alexander Dömling<br/>The progress in cancer survival and treatment has witnessed a remarkable transformation through the innovative approach of targeting the inhibitory immune checkpoint protein PD-1/PD-L1 complex by mAbs, e.g. pembrolizumab (Keytruda)....<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-21T00:00:00ZRobin van der StraatRosalie DraijerEwa SurmiakRoberto ButeraLenard LandKatarzyna Magiera-MularzBogdan MusielakJacek PlewkaTad HolakAlexander Dömlinghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90005Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90005GCorrection: Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus<div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,755-755<br/><b>DOI</b>: 10.1039/D4MD90005G, Correction</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Lakshmi Goswami, Lovely Gupta, Sayantan Paul, Maansi Vermani, Pooja Vijayaraghavan, Asish K. Bhattacharya<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-12T00:00:00ZLakshmi GoswamiLovely GuptaSayantan PaulMaansi VermaniPooja VijayaraghavanAsish K. Bhattacharyahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00693Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00693JDesign, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00693J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,733-752<br/><b>DOI</b>: 10.1039/D3MD00693J, Research Article</div><div>Ghada S. Rady, Moshira A. El Deeb, Marwa T. M. Sarg, Azza T. Taher, Amira A. Helwa<br/>In this study, novel morpholinopyrimidine-5-carbonitriles were designed and synthesized as dual PI3K/mTOR inhibitors and apoptosis inducers.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-02T00:00:00ZGhada S. RadyMoshira A. El DeebMarwa T. M. SargAzza T. TaherAmira A. Helwahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00647Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00647FGlucosamine substituted sulfonylureas: IRS–PI3K–PKC–AKT–GLUT4 insulin signalling pathway intriguing agent<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00647F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,695-703<br/><b>DOI</b>: 10.1039/D3MD00647F, Research Article</div><div>Ghadeer A. R. Y. Suaifan, Bayan Alkhawaja, Mayadah B. Shehadeh, Mridula Sharmaa, Chan Hor Kuan, Patrick Nwabueze Okechukwu<br/>Normally, skeletal muscle accounts for 70–80% of insulin-stimulated glucose uptake in the postprandial hyperglycemia state.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-01T00:00:00ZGhadeer A. R. Y. SuaifanBayan AlkhawajaMayadah B. ShehadehMridula SharmaaChan Hor KuanPatrick Nwabueze Okechukwuhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90004Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D4MD90004ACorrection: A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2<div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,753-754<br/><b>DOI</b>: 10.1039/D4MD90004A, Correction</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Shubhendu Palei, Jörn Weisner, Melina Vogt, Rajesh Gontla, Benjamin Buchmuller, Christiane Ehrt, Tobias Grabe, Silke Kleinbölting, Matthias Müller, Guido H. Clever, Daniel Rauh, Daniel Summerer<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-29T00:00:00ZShubhendu PaleiJörn WeisnerMelina VogtRajesh GontlaBenjamin BuchmullerChristiane EhrtTobias GrabeSilke KleinböltingMatthias MüllerGuido H. CleverDaniel RauhDaniel Summererhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00649Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00649BConsensus screening for a challenging target: the quest for P-glycoprotein inhibitors<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00649B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,720-732<br/><b>DOI</b>: 10.1039/D3MD00649B, Research Article</div><div>Paolo Governa, Marco Biagi, Fabrizio Manetti, Stefano Forli<br/>We identified natural compounds with P-glycoprotein inhibitory activity using a consensus virtual screening approach able to differentiate between inhibitors, substrates, and non-binders.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-22T00:00:00ZPaolo GovernaMarco BiagiFabrizio ManettiStefano Forlihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00550Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00550JDesign, synthesis, and antiproliferative evaluation of novel dehydroabietic acid-1,2,3-triazole-oxazolidinone hybrids<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00550J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,561-571<br/><b>DOI</b>: 10.1039/D3MD00550J, Research Article</div><div>Yaju Wu, Lin Huang, Xianli Ma, Xiaoqun Zhou, Qian Li, Fangyao Li<br/>Compound <strong>4p</strong> blocked the cell cycle of MGC-803 cells in G1 phase stage and induced cell apoptosis.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-11T00:00:00ZYaju WuLin HuangXianli MaXiaoqun ZhouQian LiFangyao Lihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00605Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00605KSmall molecule WDR5 inhibitors down-regulate lncRNA expression<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00605K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,636-640<br/><b>DOI</b>: 10.1039/D3MD00605K, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Jen-Yao Chang, Cora Neugebauer, Anne Mues genannt Koers, Peter 't Hart<br/>WDR5 inhibitors selective for either one of its binding sites shed light on its role in regulation of lncRNA expression.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-10T00:00:00ZJen-Yao ChangCora NeugebauerAnne Mues genannt KoersPeter 't Harthttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00652Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00652BDevelopment of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00652B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,607-611<br/><b>DOI</b>: 10.1039/D3MD00652B, Research Article</div><div>Yingpeng Liu, Radosław P. Nowak, Jianwei Che, Katherine A. Donovan, Fidel Huerta, Hu Liu, Rebecca J. Metivier, Eric S. Fischer, Lyn H. Jones<br/>Histidine-targeting covalent chemical probes of the cereblon thalidomide binding domain enabled the discovery of an isoindoline molecular glue degrader.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-09T00:00:00ZYingpeng LiuRadosław P. NowakJianwei CheKatherine A. DonovanFidel HuertaHu LiuRebecca J. MetivierEric S. FischerLyn H. Joneshttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00500Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00500CDesign, synthesis and biological evaluation of novel pyrimidine derivatives as bone anabolic agents promoting osteogenesis via the BMP2/SMAD1 signaling pathway<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00500C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,677-694<br/><b>DOI</b>: 10.1039/D3MD00500C, Research Article</div><div>Sumit K. Rastogi, Sonu Khanka, Santosh Kumar, Amardeep Lakra, Rajat Rathur, Kriti Sharma, Amol Chhatrapati Bisen, Rabi Sankar Bhatta, Ravindra Kumar, Divya Singh, Arun K. Sinha<br/>Out of thirty-one pyrimidine derivatives, compound <strong>18a</strong> was identified as the most efficacious orally bioavailable bone anabolic agent (1 pM <em>in vitro</em> and 5 mg kg<small><sup>−1</sup></small><em>in vivo</em>). It promoted osteogenesis by upregulating osteogenic gene expression <em>via</em> activation of the BMP2/SMAD1 signaling pathway.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-04T00:00:00ZSumit K. RastogiSonu KhankaSantosh KumarAmardeep LakraRajat RathurKriti SharmaAmol Chhatrapati BisenRabi Sankar BhattaRavindra KumarDivya SinghArun K. Sinhahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00611Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00611ECarbopol 940-based hydrogels loading synergistic combination of quercetin and luteolin from the herb Euphorbia humifusa to promote Staphylococcus aureus infected wound healing<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00611E" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,553-560<br/><b>DOI</b>: 10.1039/D3MD00611E, Research Article</div><div>Xiying Wu, Hao-Wei Chen, Ze-Yu Zhao, Lisha Li, Chi Song, Juan Xiong, Guo-Xun Yang, Quangang Zhu, Jin-Feng Hu<br/>An optimized QU–LU Carbopol 940-based hydrogel significantly promoted <em>S. aureus</em>-infected wound healing through anti-infection, anti-inflammation, collagen deposition and angiogenesis, revealing it as a promising alternative for infected wound repair.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-03T00:00:00ZXiying WuHao-Wei ChenZe-Yu ZhaoLisha LiChi SongJuan XiongGuo-Xun YangQuangang ZhuJin-Feng Huhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00557Ghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00557GFormulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00557G" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,595-606<br/><b>DOI</b>: 10.1039/D3MD00557G, Research Article</div><div>Asli Celebioglu, Kareena Dash, Mahmoud Aboelkheir, Mehmet E. Kilic, Engin Durgun, Tamer Uyar<br/>Naproxen/Cyclodextrin inclusion complex nanofibrous films were generated <em>via</em> electrospinning technique to develop fast-disintegrating oral drug delivery system.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-21T00:00:00ZAsli CelebiogluKareena DashMahmoud AboelkheirMehmet E. KilicEngin DurgunTamer Uyarhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00630Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00630AHighly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00630A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,704-719<br/><b>DOI</b>: 10.1039/D3MD00630A, Research Article</div><div>Avinash G Vishakantegowda, Dasom Hwang, Prashant Chakrasali, Eunhye Jung, Joo-Youn Lee, Jin Soo Shin, Young-Sik Jung<br/>The newly identified compound, <strong>7f</strong>, is a selective inhibitor of PI4KIIIβ, and shows potent and broad-spectrum anti-hRV activity with low toxicity. The compound also shows potent anti-EV activity.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-21T00:00:00ZAvinash G VishakantegowdaDasom HwangPrashant ChakrasaliEunhye JungJoo-Youn LeeJin Soo ShinYoung-Sik Junghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00621Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00621BThe allure of targets for novel drugs<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00621B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,472-484<br/><b>DOI</b>: 10.1039/D3MD00621B, Review Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Colin J. Suckling<br/>There's no single way to find new drugs; multiple targets for new medicines are effective and encourage innovation.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-13T00:00:00ZColin J. Sucklinghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00590Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00590A1-Benzylindoles as inhibitors of cytosolic phospholipase A2α: synthesis, biological activity, aqueous solubility, and cell permeability<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00590A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,641-659<br/><b>DOI</b>: 10.1039/D3MD00590A, Research Article</div><div>Imke Meyer zu Vilsendorf, Judith Einerhand, Dennis Mulac, Klaus Langer, Matthias Lehr<br/>Systematic structural variation of the cytosolic phospholipase A<small><sub>2</sub></small>α (cPLA<small><sub>2</sub></small>α) inhibitor <strong>7</strong>, recently found in a ligand-based virtual screening approach, led to the 1-benzylindole derivative <strong>122</strong>, which was about 300 times more potent than <strong>7</strong>.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-13T00:00:00ZImke Meyer zu VilsendorfJudith EinerhandDennis MulacKlaus LangerMatthias Lehrhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00457Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00457KKinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00457K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,399-415<br/><b>DOI</b>: 10.1039/D3MD00457K, Review Article</div><div>Baku Acharya, Debasmita Saha, Daniel Armstrong, Baha'a Jabali, Maha Hanafi, Alan Herrera-Rueda, Naga Rajiv Lakkaniga, Brendan Frett<br/>The development of macrocycles has emerged as an innovative approach to improve kinase inhibitor selectivity, as well as pharmacokinetic and pharmacodynamic properties.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-12T00:00:00ZBaku AcharyaDebasmita SahaDaniel ArmstrongBaha'a JabaliMaha HanafiAlan Herrera-RuedaNaga Rajiv LakkanigaBrendan Fretthttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00506Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00506BRole of heterocycles in inhibition of VEGFR-2 – a recent update (2019–2022)<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00506B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,416-432<br/><b>DOI</b>: 10.1039/D3MD00506B, Review Article</div><div>Atukuri Dorababu<br/>The review describes anti-VEGFR-2 activity of heterocycles including quinazoles, pyrimidines, isatin and azoles considering SAR for a given set of derivatives. Compounds with potent activity were emphasized with description of structural features.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-12T00:00:00ZAtukuri Dorababuhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00417Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00417ANovel quinolinepiperazinyl-aryltetrazoles targeting the blood stage of Plasmodium falciparum<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00417A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,572-594<br/><b>DOI</b>: 10.1039/D3MD00417A, Research Article</div><div>Mahesh A. Barmade, Prakhar Agrawal, Sweta R. Rajput, Prashant R. Murumkar, Bhavika Rana, Dinkar Sahal, Mange Ram Yadav<br/>This study offers compounds (<strong>66</strong> and <strong>75</strong>) as a new class of antimalarials, which are active against ACT-resistant strains of the <em>Plasmodium</em> and target several proteins of malaria parasite including the <em>Pf</em>GAP50 protein.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-08T00:00:00ZMahesh A. BarmadePrakhar AgrawalSweta R. RajputPrashant R. MurumkarBhavika RanaDinkar SahalMange Ram Yadavhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00597Fhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00597FDiscovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00597F" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,539-552<br/><b>DOI</b>: 10.1039/D3MD00597F, Research Article</div><div>Minjie Deng, Yue Gao, Peipei Wang, Wenjing Du, Gaoya Xu, Jia Li, Yubo Zhou, Tao Liu<br/>Novel FLT3/CHK1 dual agents, the representative compound <strong>30</strong>, with favorable oral PK properties, can overcome multiple FLT3-TKD and FLT3-ITD mutations.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-07T00:00:00ZMinjie DengYue GaoPeipei WangWenjing DuGaoya XuJia LiYubo ZhouTao Liuhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00612Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00612CSynthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00612C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,506-518<br/><b>DOI</b>: 10.1039/D3MD00612C, Research Article</div><div>Fei Cao, Yulong Li, Furong Ma, Zumei Wu, Zheshen Li, Zhe-Sheng Chen, Xiangdong Cheng, Jiang-Jiang Qin, Jinyun Dong<br/>Discovery of a novel P-gp inhibitor with high MDR reversal activity and low intrinsic cytotoxicity.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-07T00:00:00ZFei CaoYulong LiFurong MaZumei WuZheshen LiZhe-Sheng ChenXiangdong ChengJiang-Jiang QinJinyun Donghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00596Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00596HOvercoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00596H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,433-471<br/><b>DOI</b>: 10.1039/D3MD00596H, Review Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Marija Alešković, Marina Šekutor<br/>Supramolecular host–guest systems consisting of adamantanes and cucurbit[<em>n</em>]urils have found medicinal applications in drug delivery, controlled drug release, bioanalytics, sensing assays, bioimaging, diagnostics, hybrid nanostructures and beyond.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-06T00:00:00ZMarija AleškovićMarina Šekutorhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00564Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00564JSynthesis of novel rapanone derivatives via organocatalytic reductive C-alkylation: biological evaluation of antioxidant properties, in vivo zebrafish embryo toxicity, and docking studies<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00564J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,623-635<br/><b>DOI</b>: 10.1039/D3MD00564J, Research Article</div><div>Vaithiyalingam Mariyappan, Ganesh Munuswamy-Ramanujam, Mohankumar Ramasamy<br/>The synthesis of novel rapanone derivatives <em>via</em> organocatalytic reductive C-alkylation, their biological evaluation of antioxidant properties and <em>in vivo</em> zebrafish embryo zero toxicity, and their molecular docking studies binding interactions are crucial for the biological potential.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-04T00:00:00ZVaithiyalingam MariyappanGanesh Munuswamy-RamanujamMohankumar Ramasamyhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00585Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00585BDiscovery of dual-action phenolic 4-arylidene-isoquinolinones with antioxidant and α-glucosidase inhibition activities<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00585B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,519-538<br/><b>DOI</b>: 10.1039/D3MD00585B, Research Article</div><div>Eduardo Hernández-Vázquez, Siseth Martínez-Caballero, Diana Aldana-Torres, Samuel Estrada-Soto, Antonio Nieto-Camacho<br/>A series of phenolic isoquinolinones with dual action (antioxidant and α-glucosidase inhibition) is shown for the first time. <em>In vivo</em> assays also demonstrate the reduction of blood glucose after administration of sucrose.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-04T00:00:00ZEduardo Hernández-VázquezSiseth Martínez-CaballeroDiana Aldana-TorresSamuel Estrada-SotoAntonio Nieto-Camachohttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00467Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00467HColorectal anticancer activity of a novel class of triazolic triarylmethane derivatives<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00467H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,660-676<br/><b>DOI</b>: 10.1039/D3MD00467H, Research Article</div><div>Ameni Hadj Mohamed, Aline Pinon, Nathalie Lagarde, Christophe Ricco, Elizabeth Goya-Jorge, Hadley Mouhsine, Moncef Msaddek, Bertrand Liagre, Maité Sylla-Iyarreta Veitía<br/>Triazolic TAM <strong>9b</strong>, with its pronounced anticancer activity, highlight its potential as a promising drug candidate for the treatment of colorectal cancer.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-04T00:00:00ZAmeni Hadj MohamedAline PinonNathalie LagardeChristophe RiccoElizabeth Goya-JorgeHadley MouhsineMoncef MsaddekBertrand LiagreMaité Sylla-Iyarreta Veitíahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00581Jhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00581JResearch progress of metal–organic framework nanozymes in bacterial sensing, detection, and treatment<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00581J" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,380-398<br/><b>DOI</b>: 10.1039/D3MD00581J, Review Article</div><div>Yiwei An, Xuankun Fang, Jie Cheng, Shuiyuan Yang, Zuanguang Chen, Yanli Tong<br/>In this review, we focus on the application of MOF-based nanozymes with natural enzyme activity in bacterial detection and therapy, and we believe that MOF-based nanozymes will have a broader development space in the biomedical field in the future.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-12-01T00:00:00ZYiwei AnXuankun FangJie ChengShuiyuan YangZuanguang ChenYanli Tonghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00569Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00569KLinker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody–drug conjugates<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00569K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,612-622<br/><b>DOI</b>: 10.1039/D3MD00569K, Research Article</div><div>Lu Wang, Adrian D. Hobson, Paulin L. Salomon, Julia Fitzgibbons, Jianwen Xu, Sean McCarthy, Kan Wu, Ying Jia, Axel Hernandez, Xiang Li, Zhou Xu, Zhongyuan Wang, Yajie Yu, Junxian Li, Lin Tao<br/>Maleimide is used in antibody–drug conjugate (ADC) generation to attach the drug-linker to the antibody. Maleimide linkers with hydrolysis-enabled maleimides were designed. Corresponding ADCs were made and subjected to thermal stress, and succinimide ring hydrolysis and drug release were measured.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-11-27T00:00:00ZLu WangAdrian D. HobsonPaulin L. SalomonJulia FitzgibbonsJianwen XuSean McCarthyKan WuYing JiaAxel HernandezXiang LiZhou XuZhongyuan WangYajie YuJunxian LiLin Taohttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00589Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00589EDesign, synthesis and evaluation of 2-phenylpyrimidine derivatives as novel antifungal agents targeting CYP51<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00589E" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,492-505<br/><b>DOI</b>: 10.1039/D3MD00589E, Research Article</div><div>Zixuan Gao, Jiachen Zhang, Kejian Li, Yixiang Sun, Xudong Wu, Guoqi Zhang, Rongrong Liu, Rui Liu, Dongmei Zhao, Maosheng Cheng<br/>We designed and synthesised a series of novel CYP51 inhibitors. Three rounds of structural optimisation and modification obtained compound <strong>C6</strong> which showed superior antifungal activity.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-11-21T00:00:00ZZixuan GaoJiachen ZhangKejian LiYixiang SunXudong WuGuoqi ZhangRongrong LiuRui LiuDongmei ZhaoMaosheng Chenghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00548Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00548HThiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00548H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, <b>15</b>,485-491<br/><b>DOI</b>: 10.1039/D3MD00548H, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Joseph Hennessy, Piotr Klimkowski, Daniel Singleton, Alex Gibney, Malou Coche, Nicholas P. Farrell, Afaf H. El-Sagheer, Tom Brown, Andrew Kellett<br/>We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne–amine nucleobase monomer called AP-C3-dT that enables dual ‘click’ platinum(<small>II</small>) drug conjugation and thiazole orange fluorophore coupling.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2023-10-31T00:00:00ZJoseph HennessyPiotr KlimkowskiDaniel SingletonAlex GibneyMalou CocheNicholas P. FarrellAfaf H. El-SagheerTom BrownAndrew Kelletthttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00601Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00601HUnusual Ni⋯Ni interaction in Ni(II) complexes as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron drugs<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00601H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00601H, Research Article</div><div>Simranjeet Singh, Mukesh Choudhary<br/>In this study, two nickel(<small>II</small>) coordination complexes [Ni(L)]<small><sub>2</sub></small>(<strong>1</strong>) and [Ni(L)]<small><sub><em>n</em></sub></small>(<strong>2</strong>) of a tetradentate-N<small><sub>2</sub></small>O<small><sub>2</sub></small> donor Schiff base ligand (<strong>H</strong><small><sub><strong>2</strong></sub></small><strong>L</strong>) were synthesized, designed and characterized via spectroscopic and SC-XRD analysis, and molecular docking study.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-20T00:00:00ZSimranjeet SinghMukesh Choudharyhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00529Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00529ADevelopment of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activities<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00529A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00529A, Research Article</div><div>Eva Amatya, Chitra Subramanian, Mark S. Cohen, Brian S. J. Blagg<br/>Inhibition of the Hsp90 C-terminal domain offers a promising opportunity to treat numerous diseases/indications.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-18T00:00:00ZEva AmatyaChitra SubramanianMark S. CohenBrian S. J. Blagghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00730Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00730HDesign, Synthesis, In Vitro and In Silico Evaluation of Indole Based Tetrazole Derivatives as Putative Anti-Breast Cancer Agent<div><i><b>RSC Med. Chem.</b></i>, 2024, Accepted Manuscript<br/><b>DOI</b>: 10.1039/D3MD00730H, Research Article</div><div>Kamalpreet Kaur, Harkomal Verma, Prabhakar Gangwar, Monisha Dhiman, Vikas Jaitak<br/>Abstract A series of new indole-tetrazole derivatives were designed and synthesized to develop potential anti-breast cancer agents. The compounds exhibited in vitro anti-proliferative activity against ER-α positive T-47D (IC50 =...<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-19T00:00:00ZKamalpreet KaurHarkomal VermaPrabhakar GangwarMonisha DhimanVikas Jaitakhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00665Dhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00665DStereoselective synthesis and antiproliferative activity of allo-gibberic acid-based 1,3-aminoalcohol regioisomers<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00665D" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00665D, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Zein Alabdeen Khdar, Tam Minh Le, Zsuzsanna Schelz, István Zupkó, Zsolt Szakonyi<br/>Starting from gibberellic acid (GA3), a library of <em>allo</em>-gibberic acid-based aminoalcohols was synthesised, and their antiproliferative effects were assayed by <em>in vitro</em> MTT method against a panel of human cancer cell lines (HeLa, SiHa, A2780, MCF-7, MDA-MB-231).<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-12T00:00:00ZZein Alabdeen KhdarTam Minh LeZsuzsanna SchelzIstván ZupkóZsolt Szakonyihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00663Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00663HDiscovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00663H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00663H, Research Article</div><div>Lin Tang, Minxiong Li, Changlin Bai, Xuejin Feng, Haiyang Hu, Yufen Yao, Baiqing Li, Hongwei Li, Guohong Qin, Ning Xi, Genpin Lv, Lei Zhang<br/>Three series of benzoheterocyclic-substituted amide derivatives were designed and synthesized in this work, and compound <strong>17a</strong> was discovered to be a novel potent inhibitor of ASK1 with good druggability.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-30T00:00:00ZLin TangMinxiong LiChanglin BaiXuejin FengHaiyang HuYufen YaoBaiqing LiHongwei LiGuohong QinNing XiGenpin LvLei Zhanghttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00490Bhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00490BReinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00490B" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00490B, Research Article</div><div>Hari Madhav, G. Srinivas Reddy, Zeba Rizvi, Ehtesham Jameel, Tarosh S. Patel, Abdur Rahman, Vikas Yadav, Sadaf Fatima, Fatima Heyat, Kavita Pal, Amisha Minju-OP, Naidu Subbarao, Souvik Bhattacharjee, Bharat C. Dixit, Puran Singh Sijwali, Nasimul Hoda<br/>The present study unveils a thorough reevaluation of diphenylmethylpiperazine and pyrazine-derived molecular hybrids, introducing them as a new class of antimalarials.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-01T00:00:00ZHari MadhavG. Srinivas ReddyZeba RizviEhtesham JameelTarosh S. PatelAbdur RahmanVikas YadavSadaf FatimaFatima HeyatKavita PalAmisha Minju-OPNaidu SubbaraoSouvik BhattacharjeeBharat C. DixitPuran Singh SijwaliNasimul Hodahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00677Hhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00677HIndole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00677H" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00677H, Review Article</div><div>Wei Zeng, Chi Han, Sarah Mohammed, Shanshan Li, Yixuan Song, Fengxia Sun, Yunfei Du<br/>Over the past few decades indole derived drugs has gained great attention from medicinal chemists. This review provides an overview of all marked drugs containing the indole scaffold and their targets, pharmacological activities and SAR studies.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-30T00:00:00ZWei ZengChi HanSarah MohammedShanshan LiYixuan SongFengxia SunYunfei Duhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00619Khttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00619KDesign, synthesis and biological evaluation of rhein–piperazine–furanone hybrids as potential anticancer agents<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00619K" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00619K, Research Article</div><div>Yu He, Si-Si Zhang, Meng-Xue Wei<br/>Novel rhein–piperazine–furanone hybrids, <strong>5</strong>, were designed and synthesized efficiently. Hybrid <strong>5e</strong>, the most potent compound, was 46- and 35-fold more toxic to human lung cancer A549 cells than rhein and the reference cytarabine (CAR), respectively.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-02-13T00:00:00ZYu HeSi-Si ZhangMeng-Xue Weihttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00737Ehttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00737EN-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00737E" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00737E, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY-NC.png' alt='Creative Commons Licence' border='none'/></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by-nc/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution-NonCommercial 3.0 Unported Licence.</a></div><div>Rostom Ahmed-Belkacem, Joris Troussier, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart<br/>SAH-derived bisubstrates of SARS-CoV-2 cap RNA <em>N</em>7-methyltransferase were synthesized, and two adenosines with an <em>N</em>-arylsulfonamide core attached by an <em>N</em>-ethylthioether linker proved to be effective inhibitors in the submicromolar range.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-26T00:00:00ZRostom Ahmed-BelkacemJoris TroussierAdrien DelpalBruno CanardJean-Jacques VasseurEtienne DecrolyFrançoise Debarthttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00609Chttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00609CA concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00609C" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00609C, Research Article</div><div><img alt='Open Access' src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/open_access_blue.png' /> Open Access</div><div><a rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window'> <img src='http://sod-a.rsc-cdn.org/pubs.rsc-uat.org/content/NewImages/CCBY.png' alt='Creative Commons Licence' border='none' /></a>&nbsp This article is licensed under a <a text-decoration=none rel='license' href='http://creativecommons.org/licenses/by/3.0/' target='_blank' title='This link will open in a new browser window' >Creative Commons Attribution 3.0 Unported Licence.</a></div><div>Insa Klemt, Viktor Reshetnikov, Subrata Dutta, Galyna Bila, Rostyslav Bilyy, Itziar Cossío Cuartero, Andrés Hidalgo, Adrian Wünsche, Maximilian Böhm, Marit Wondrak, Leoni A. Kunz-Schughart, Rainer Tietze, Frank Beierlein, Petra Imhof, Sabrina Gensberger-Reigl, Monika Pischetsrieder, Marlies Körber, Tina Jost, Andriy Mokhir<br/>We introduced a concept of prodrugs activated by H<small><sub>2</sub></small>O<small><sub>2</sub></small> and mitochondrial OH<small><sup>−</sup></small>, which is applicable to camptothecin and its derivatives.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-31T00:00:00ZInsa KlemtViktor ReshetnikovSubrata DuttaGalyna BilaRostyslav BilyyItziar Cossío CuarteroAndrés HidalgoAdrian WünscheMaximilian BöhmMarit WondrakLeoni A. Kunz-SchughartRainer TietzeFrank BeierleinPetra ImhofSabrina Gensberger-ReiglMonika PischetsriederMarlies KörberTina JostAndriy Mokhirhttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00587Ahttp://pubs.rsc.org/en/Content/ArticleLanding/2024/MD/D3MD00587ACytochrome bd oxidase: an emerging anti-tubercular drug target<div><p><img align="center" src="/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=D3MD00587A" /></p></div><div><i><b>RSC Med. Chem.</b></i>, 2024, Advance Article<br/><b>DOI</b>: 10.1039/D3MD00587A, Review Article</div><div>Pallavi Saha, Samarpita Das, Harish K. Indurthi, Rohit Kumar, Arnab Roy, Nitin Pal Kalia, Deepak K. Sharma<br/>Cytochrome bd (cyt-<em>bd</em>) oxidase, one of the two terminal oxidases in the <em>Mycobacterium tuberculosis</em> (<em>Mtb</em>) oxidative phosphorylation pathway, plays an indispensable role in maintaining the functionality of the metabolic pathway under stressful conditions.<br/>To cite this article before page numbers are assigned, use the DOI form of citation above.<br/>The content of this RSS Feed (c) The Royal Society of Chemistry</div>2024-01-27T00:00:00ZPallavi SahaSamarpita DasHarish K. IndurthiRohit KumarArnab RoyNitin Pal KaliaDeepak K. Sharma