RSC - Nat. Prod. Rep. latest articles

Electrophilic and nucleophilic enzymatic cascade reactions in biosynthesis

Nat. Prod. Rep., 2012, Advance Article
DOI: 10.1039/C2NP00078D, Review

Barbara T. Ueberbacher, Melanie Hall, Kurt Faber
Cyclic terpenoids and polyethers are formed via enzyme-initiated cascade reactions for ring formation, which proceed either via electrophilic (cationic) or nucleophilic (anionic) pathways through (i) triggering of the cascade ('initiation'), (ii) 'proliferation' of the cyclization and (iii) 'termination' of the cascade.
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Didemnins, tamandarins and related natural products

Nat. Prod. Rep., 2012, Advance Article
DOI: 10.1039/C2NP00065B, Review

Jisun Lee, Judith N. Currano, Patrick J. Carroll, Madeleine M. Joullie
This review highlights the long-standing study of didemnins and its critical application towards the understanding of the molecular mechanism of action of tamandarins and their potential use as therapeutic agents.
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Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms

Nat. Prod. Rep., 2012, Advance Article
DOI: 10.1039/C2NP00088A, Review

Zhao-Li Zhou, Ya-Xi Yang, Jian Ding, Yuan-Chao Li, Ze-Hong Miao
This review covers research efforts of the last forty years, focusing on the structural modifications, structure-activity relationships, pharmacology and clinical development of triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F.
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The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus

Nat. Prod. Rep., 2012, Advance Article
DOI: 10.1039/C2NP00073C, Review

Xiao-Long Yang, Jing-Ze Zhang, Du-Qiang Luo
A growing body of evidence indicates that the Pestalotiopsis genus represents a huge and largely untapped resource of bioactive metabolites. This review systematically surveys the taxonomy, biology and chemistry of the Pestalotiopsis genus. It also summarises the biosynthetic relationships and chemical synthesis of secondary metabolites.
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