RSC - Nat. Prod. Rep. latest articles

Skeleton innovation versus structural diversification in terpenoid discovery: chemoinformatic insights from TeroKit

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00004E, Highlight

Tao Zeng, Jiahao Li, Ruibo Wu
Contrasting skeletal exploration with structural exploitation reveals a clear reality: terpenoid discovery in the past six years is overwhelmingly dominated by the modification-driven exploitation of established skeletons.
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Advancing natural product R&D&I: guide for compliance with responsible research and innovation, ethics, Nagoya and Cartagena Protocols, and intellectual property protection

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00072F, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Susana P. Gaudêncio, Belma Kalamujić Stroil, Lucie Novoveska, Céline Rebours, Xenia T. Schneider
RRI, ethical standards, the Nagoya and Cartagena Protocols, and IP frameworks influence natural products R&D&I and the bioeconomy, providing a foundation for sustainable and equitable resource use while promoting innovation and growth.
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Hot off the Press

Nat. Prod. Rep., 2026, 43,585-589
DOI: 10.1039/D6NP90014C, Hot off the Press Article

Robert A. Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as spectaterpenoid A from Aspergillus spectabilis.
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Microbial natural products activated by plant stress

Nat. Prod. Rep., 2026, 43,590-596
DOI: 10.1039/D5NP00062A, Highlight

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Barbara I. Adaikpoh
Highlighting studies that link plant stress to the activation of antimicrobial biosynthetic gene clusters in beneficial microbes, thereby illustrating chemical interactions in the plant's microenvironment that can inform natural product discovery.
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Structure, bioactivity, biosynthesis, and synthesis of corynanthe alkaloids

Nat. Prod. Rep., 2026, 43,746-778
DOI: 10.1039/D5NP00051C, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chenxu Liu, Mengqi Tong, Kouharu Otsuki, Wei Li, Feng Feng, Jie Zhang
This paper reviews the structure, biosynthesis, synthesis, and activity of corynanthe alkaloids with the aim of providing new perspectives and discoveries for researchers in this field.
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Microbe-derived aromatic polyketides toward MRSA infection: current advances and perspectives

Nat. Prod. Rep., 2026, 43,718-745
DOI: 10.1039/D5NP00061K, Review Article

Fangfang Duan, Jiaying Lai, Linjie Wei, Siran Li, Polina Lopukhina, Zihuan Sang, Chen Chen, Xiaoyi Wei, Hongxin Liu, Haibo Tan
Methicillin-resistant Staphylococcus aureus (MRSA), one of the most common multidrug-resistant (MDR) bacterial strains, has severely threatened global healthcare for decades due to its high morbidity and mortality rates.
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Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects

Nat. Prod. Rep., 2026, 43,685-717
DOI: 10.1039/D5NP00074B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Abdul Bari Shah, Young Jun Kim, Kyeong Seon Lee, Sang Hoon Han, Youngjoo Byun, Ki Yong Lee
The increasing prevalence of allergic diseases and immunological disorders is a significant public health issue requiring the development of novel therapeutic approaches.
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Discovery, bioactivities and biosynthesis of spirooxindole alkaloids

Nat. Prod. Rep., 2026, 43,650-684
DOI: 10.1039/D5NP00046G, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ruijie Chen, Lihan Zhang, Xiaoyang Zhao, Zhuangjie Fang, Liping Zhang, Qingbo Zhang, Changsheng Zhang, Yiguang Zhu
This review provides a comprehensive summary of the origin, activities, and biosynthesis of spirooxindole-containing alkaloids derived from a variety of organisms, including actinomycetes, cyanobacteria, fungi, plants, and invertebrates.
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Green gold of the Pacific: unlocking compounds from terrestrial flora for antitumor and immunomodulatory drug discovery

Nat. Prod. Rep., 2026, 43,627-649
DOI: 10.1039/D5NP00073D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Paul Huchedé, Vincent Dumontet, Mariko Matsui
This review highlights the Pacific region's terrestrial flora and explores its natural products as a source of novel antitumor and immunomodulatory compounds for drug discovery.
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A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids

Nat. Prod. Rep., 2026, 43,597-626
DOI: 10.1039/D5NP00053J, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Marcel Kulike-Koczula, Dominik Heimann, Tobias Eulberg, Daniel Kohnhäuser, Roderich D. Süssmuth, Mark Brönstrup
This article summarizes insights on a new class of antibiotics defined by albicidins and cystobactamids. It presents their biosynthesis, total synthesis and lead optimization, the mechanisms of action and resistance, and the antibiotic properties.
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β-Lactam antibiotics and β-lactamases: historical perspectives and a review of β-lactamase inhibitors derived from natural products

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00081E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Phanankosi Moyo, Ikhane O. Albert, Neo Hlungwani, Thulani Sibanda, Perfoy Lumu, Ndivhuwo Kevin Khorommbi, Gurleen Kaur, Karina Calvopina Tapia, George Siegwart, Nana Kwaku Buabeng, Cynthia A. Danquah, Lyndy J. McGaw, Sekelwa Cosa, Christopher J. Schofield, Vinesh J. Maharaj
From the discovery of natural β-lactam antibiotics to the rise of serine and metallo-β-lactamases, this review traces their co-evolution and highlights microbial and plant-derived natural products as promising sources of new β-lactamase inhibitors.
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A comprehensive review of the structural diversity, biosynthesis and chemical synthesis of Lasiodiplodia spp. natural products

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00090D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Maria Michela Salvatore, Marco Masi, Marina DellaGreca, Anna Andolfi
Lasiodiplodia is a prominent genus within the Botryosphaeriaceae family which is known as a plant pathogen. Species of Lasiodiplodia are prolific sources of bioactive secondary metabolites.
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Syntheses of furan natural products

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00005C, Review Article

Bichu Cheng
This review discusses recent developments in the syntheses of furan natural products. The general methods for furan synthesis are extracted from total syntheses and categorized.
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New secondary metabolites isolated from Streptomyces species

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00069F, Review Article

William J. Price Cunliffe, Peter J. Rutledge
This review highlights novel secondary metabolites – including peptides, terpenoids, polyketides, alkaloids, and others – that were isolated from Streptomyces bacteria and reported for the first time between 2021 and 2024.
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Construction of C(sp3)–C(sp3) attached ring motifs in natural product synthesis

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00024J, Review Article

Søren L. B. Møller, Thomas B. Poulsen
A survey of synthetic approaches to saturated C(sp³)–C(sp³) attached ring systems in natural products, with emphasis on direct fragment couplings that enable efficient assembly of complex polycyclic frameworks.
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Fungal polyketide biosynthesis as a platform for designer natural products

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00092K, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pingxin Lin, Zhenhao Fu, Ye Li, Yeo Joon Yoon, Sang Yup Lee
Programming rules of fungal iterative polyketide synthases enable combinatorial biosynthesis and cell-factory engineering to expand polyketide chemical diversity.
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