RSC - Nat. Prod. Rep. latest articles

Visual cycle-derived bisretinoids as endogenous natural products: enzyme-free formation, photochemical reactivity, and retinal degeneration

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00038J, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Hye Jin Kim, Janet R. Sparrow, Young Pyo Jang
This review reframes retinal bisretinoids as autochthonous natural products, demonstrating how polyene electrophilicity and non-enzymatic aza-electrocyclization dictate their inevitable biogenesis and subsequent photochemical toxicity.
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Non-strigolactone natural products interfering with parasitic weed development

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00077G, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jesús G. Zorrilla, Antonio Cala Peralta, Mónica Fernández-Aparicio, Marco Masi, Francisco A. Macías, Alessio Cimmino
Non-strigolactone compounds regulate parasitic plant germination, growth, and host recognition, often acting synergistically with root signals. They also affect chemotropism and haustorium formation, revealing a complex chemical network.
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Biosynthetic crosstalk in bacteria: routes to chimeric natural products

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00048G, Highlight

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Wen-Chao Yu, Zhiyuan Peng, Yan-Song Ye, Qihao Wu
Distributed biosynthetic pathways can generate chimeric natural products missed by single cluster genome mining; multi-class metabolomics offers a route to identify these overlooked hybrid scaffolds.
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Genomic scale analysis of assembly-line polyketide synthase diversity and evolution

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00052E, Review Article

Seokyoung Lee, Chaitan Khosla
PKSClusterDB provides a curated genomic-scale catalogue of assembly-line PKSs, enabling anchor-window analysis that reveals family-resolved evolutionary patterns and helps interpret orphan pathways and biosynthetic diversity.
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Asymmetric synthesis of 3,3-disubstituted oxindoles: methodologies and applications in natural product synthesis

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00015K, Review Article

Rui Yang, Lihua Wei, Zhiqiang Ma
This review summarizes the diverse asymmetric strategies for constructing 3,3-disubstituted oxindoles and discusses their applications in natural product synthesis, with an emphasis on the construction of the key chiral intermediates.
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Mass spectrometry as the unifying force in natural product sciences

Nat. Prod. Rep., 2026, 43,1070-1072
DOI: 10.1039/D6NP90018F, Editorial

Mehdi A. Beniddir, Nadja B. Cech, Roger Linington, Neha Garg
Mehdi A. Beniddir, Nadja B. Cech, Roger Linington and Neha Garg introduce the Natural Product Reports themed issue on Mass spectrometry metabolomics in natural products research.
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Hot off the Press

Nat. Prod. Rep., 2026, 43,1073-1077
DOI: 10.1039/D6NP90022D, Hot off the Press Article

Robert A. Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as humupulusone A from Humulus lupulus.
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Cultivar to chemotype: characterizing complex botanicals with mass spectrometry metabolomics

Nat. Prod. Rep., 2026, 43,1181-1200
DOI: 10.1039/D5NP00040H, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Joshua J. Kellogg, R. Teal Jordan, Madhusha M. Ranaweera, Kelsey Custer, Savannah G. Anez, Julia Bendlin, Francisco T. Chacon, Xiaoling Chen
To ensure safe and effective botanical products, the identity and integrity of the source material is essential. Mass spectrometry-based metabolomics provides a powerful, sensitive analytical tool to characterize these complicated chemical mixtures.
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Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches

Nat. Prod. Rep., 2026, 43,1130-1180
DOI: 10.1039/D5NP00022J, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Eleni V. Mikropoulou, Aikaterini Basdeki, Maria Halabalaki
This review investigates the journey of metabolite identification and quantification of natural products (NPs), exploiting mass spectrometry approaches from the early 1980s to the current developments in this field.
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Scalability of mass spectrometry-based metabolomics for natural extracts libraries exploration: current status, challenges, and opportunities

Nat. Prod. Rep., 2026, 43,1106-1129
DOI: 10.1039/D5NP00034C, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Adriano Rutz, Wout Bittremieux, Robin Schmid, Olivier Cailloux, Justin J. J. van der Hooft, Mehdi A. Beniddir
This review aims at highlighting how scalability of the mass spectrometry-based discovery pipeline plays a pivotal role in finding novel bioactives in natural extracts libraries.
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Mass spectrometry-based metabolomics approaches to interrogate host–microbiome interactions in mammalian systems

Nat. Prod. Rep., 2026, 43,1078-1105
DOI: 10.1039/D5NP00021A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Atharva S. Kulkarni, Guilherme M. P. Carrara, Jiangpeiyun Jin, Jarrod Laro, Thilini Peramuna, Laura-Isobel McCall, Neha Garg
Chemical crosstalk is universal to all life, niche-specific, and essential to thrive.
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The elansolids: how nature shows chemists how to tame p-quinone methides

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00030D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Liang-Liang Wang, Xiao-Qin Zhou, Andreas Kirschning
Using elansolids as a case study, it is demonstrated how nature tames the highly reactive p-quinone methide by controlling its reactivity and conformation in a very efficient manner.
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Challenges and opportunities in the synthesis of biologically relevant flavonoids and their glycosides

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00008H, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Debabrata Giri, Saikat Mondal, M. Carmen Galan, Abhijit Sau
This review provides a current perspective on the recent advancements in flavonoid chemistry and their role in the development of novel therapeutic agents.
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Cinnamoyl-containing non-ribosomal peptides: discovery, bioactivity and biosynthesis

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00084J, Review Article

Yuyang Wang, Yanqing Li, Yingying Chen, Jianhua Ju, Zhuo Shang, Junying Ma
The chemical diversity, biological activities, biosynthesis and expanding chemical diversity of cinnamoyl-containing non-ribosomal peptides.
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Decoding multidimensional regulatory networks in Streptomyces to accelerate natural product discovery and production

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00022C, Review Article

Yongjae Lee, Woori Kim, Chanyoung Joung, Hyeseong Kim, Namil Lee, Byung-Kwan Cho
Advances in genome-scale analytical tools have expanded our knowledge of regulatory networks in Streptomyces, providing a transferable framework for the systematic activation of biosynthetic gene clusters for natural product discovery and production.
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Ecological context for bacterial natural products discovery

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00018E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jonathan Parra, Marla I. Macias-Contreras, Dulce G. Guillén Matus, Katherine R. Duncan
This review highlights recent studies and considerations towards ecological approaches to natural product discovery.
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Emerging technologies for the discovery of biosynthetic genes in plants

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00011H, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Anne Jaczkowski, Arne Bültemeier, Benedikt Seligmann, Boas Pucker, Jakob Franke
Compared to microbial natural product research, elucidating biosynthetic pathways in plants requires distinct methodological approaches. This review describes emerging technologies for discovering biosynthetic genes in plants.
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Microbial biotransformation of plant-derived metabolites: mechanisms, pathways, and multi-omics integration

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00039H, Review Article

Youngse Oh, Jaeyoun Lee, Soohyun Um, Seung Hyun Kim
This review presents a reaction-class atlas of microbial biotransformations of plant-derived metabolites and highlights how enzymatic mechanisms and multi-omics approaches reveal metabolic diversity in complex microbial communities.
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Rare functional groups and unique scaffolds in Streptomyces natural products

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00012F, Review Article

Sanyuan Shi, Xuerui Jin, Gaoli Wang, Xuewei Hao, Jing Xie, Liujie Huo, Yunzi Luo
This review highlights Streptomyces natural products with rare functional groups, unique scaffolds, and atypical modifications, examining the enzymatic mechanisms to link biosynthetic diversity with synthetic biology applications.
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Advances in the discovery and functional analysis of Anti-infective and immunomodulatory natural products from host-associated microbiomes

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00003G, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sebastian Götze, Christine Beemelmanns
This review highlights discoveries from 2018 to 2025 of microbiome-derived natural products with anti-infective and immunomodulatory actvities, and urges to more targeted OMICs approaches to fully harness the encoded biosynthetic capacity.
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Natural products with atypical atoms: unveiling structures, biosynthetic pathways, and bioactivities

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00083A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yeo Jin Lee, Hyeon-Jeong Hwang, Jungro Lee, Hyeon Seung Park, Juwan Son, Mohammad Seyedsayamdost, Munhyung Bae, Seoung Rak Lee, Yun Kwon
Rare elements in natural products unlock new chemical space, biosynthetic logic, and biological activities.
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Inverse stable isotopic labeling for natural product characterization and discovery

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00014B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jose Miguel D. Robes, Aaron W. Puri
This review highlights applications of inverse stable isotope labeling in natural product research, including biosynthesis, structural elucidation, and discovery, spanning 2005 to 2026.
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Unlocking hidden enzymatic chemistry in natural product biosynthesis

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00034G, Highlight

Micah Harris, Asher Paul, Edward Kalkreuter
This highlight reviews many of the existing and emerging strategies for prioritizing and accessing novel enzymology from microbial biosynthesis.
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Synthetic biology as a game-changer for endangered medicinal orchids: biosynthesis, engineering and conservation

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00027D, Review Article

Lin Qiu, Xianghui Chen, Zhan Luo, Min Jiang, Hu Chen, Biyu Hou, Haizheng Yu, Ning Li, Lei Zhang
Synthetic biology acts as a game-changer for endangered medicinal orchids, enabling a transition from resource scarcity and extraction inefficiency to sustainable conservation through pathway decoding, chassis engineering and green biomanufacturing.
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