RSC - Org. Biomol. Chem. latest articles

Cyclooctadiene-Derived Cage-Divergent Synthesis of Heteroadamantanes and Alternative Polycyclic Systems

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00368K, Communication

Vladyslav Lysenko, Ioann O. Popov, Evgeniy Y. Slobodyanyuk, Eduard Rusanov, Olexandr Ye. Pashenko, Dmitriy M. Volochnyuk, Serhiy V. Ryabukhin
Widely available cycloocta-1,5-diene (COD) serves as a highly versatile and convenient platform for cage-divergent synthesis of diverse three-dimensional frameworks. Here, we demonstrate streamlined, COD-based protocols delivering oxygen- and nitrogen-doped adamantane...
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tert-Butyl hydroperoxide mediated Wacker-type oxidations: taking advantage of hexafluoro-2-propanol for challenging substrates

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D5OB01683E, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Calum Maguire, Qun Cao, Selena C. L. Gilmer, Bill C. Hawkins, Peter C. Knipe, Mark J. Muldoon
HFIP improves Pd-catalysed Wacker-type oxidation reactions using TBHP as the oxidant. The method was applied to a series of substituted O-allylphenols along with some more complex derivatives.
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Substituent Effects Direct Anion Transport in Aryl-Triazole Derivatives

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00449K, Communication

Juejiao Fan, Wei Wu, Xinyi Dou, Jiakai Huo, Xu Tang, Songze Li, Chunyan Bao
A series of aryl triazole derivatives with varying electronic substituents but comparable hydrophobicity were synthesized for chloride transmembrane transport. Their activity decreased as the electron-withdrawing strength weakened (EC₅₀ ranging from...
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A convenient synthesis of 2,4-diarylpyrroles from β-cyanoketones via reductive rearrangement of in situ generated 2-aminofurans

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00423G, Paper

Dmitrii Aksenov, Tatyana S. Galushko, Daniil S. Garkusha, Maria S. Volosovtsova, Nicolai Alexandrovich Aksenov, Nikolai A. Arutiunov, Daria I. Murashkina, Alexander V Aksenov
A new, efficient, and regioselective method for the synthesis of 2,4-diarylpyrroles based on readily available β-cyanoketones has been developed. The cascade reaction proceeds through the in situ formation of 2-aminofurans...
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Dual Strategy Approach for an Aliphatic Nitrile Directing Group Assisted Palladium-Catalyzed meta-C–H Arylation/Acetoxylation of Arenes

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00415F, Communication

Raut Kaustubh, Dasari Srinivas, Ch Subrahamayam, Satyanarayana Gedu
The meta-selective arylation of simple aliphatic nitirile-bearing arylmethanesulfonic acid derivatives under microwave-accelerated conditions has been developed. Also presents the meta-arylation of 3-phenylpropanoic acid esters tethered to a nitrile template under...
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Deoxygenation of carboxylic acids-based radical-polar crossover process for modular access to functionalized cyclopropanes

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00409A, Communication

Haiyan Ding, Yan Li, Li Zhang, Yewen Fang
Herein, a photoredox-catalyzed strategy has been successfully developed for the preparation of arylformylmethyl cyclopropanes via acylative coupling of (hetero)aryl carboxylic acids with homoallyl tosylates. This deoxygenation-based radical-polar crossover process was...
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Visible light-induced synthesis of benzofuro[3,2b]pyridines from aurone-derived azadienes

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00444J, Communication

Jiale Fan, Jianwei Xie, Ping Lu, Yanguang Wang
The visible light-induced regioselective synthesis of benzofuro[3,2b]pyridines from aurone-derived azadienes is achieved through a radical dimerization/aromatization mechanism under catalystfree conditions. In specific instances, spiro[benzofuran-2,2′benzofuro[3,2-b]pyridines] are formed as intermediates, which can...
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Efficient synthesis of quinoline–enone esters via copper-catalyzed coupling with electron-deficient alkynes and exploration of fluorescence in difluoroboron complexes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00213G, Communication

Xiaojiao Wang, Xin Cao, Zhenjiang Li, Jialin Qi, Shuwen Gong
Efficient synthesis of quinolinyl–enaminones and enols and novel BF₂ fluorophores via a copper-catalyzed, 100% atom-economic coupling reaction.
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Metal-free electrochemical decarboxylative cyclization of N-aryl glycines with azobenzenes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00350H, Paper

Wenji Zhu, Xuyuan He, Yujun Gao, Mengqi Liu, Jincheng Ye, Shulin Ning
A highly regioselective decarboxylative cyclization strategy of N-aryl glycines with azobenzenes under mild electrochemical conditions is introduced, which could provide direct access to a diverse set of 1,2,4-triazolidines.
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Access to arylurazoles bearing both central and C-N axial chirality via asymmetric desymmetrization catalyzed by chiral phosphoric acid

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00223D, Communication

Wenhui Wu, Wenkai Li, Yongqiang Xu, Yuhan Zhou, Jingping Qu, Baomin Wang
We report an asymmetric desymmetrization of 4-aryl-1,2,4triazole-3,5-diones (ATADs) through conjugate addition of pyrazolones catalyzed by chiral phosphoric acid. This reaction simultaneously constructs central and C-N axial chirality, affording atropisomeric arylurazoles...
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Dual photoredox and palladium catalysis-enabled cyclization reactions

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00243A, Review Article

Xiangqian Zhao, Qi-Yan Lv, Erqing Li, Kai Sun, Zhong-Yan Cao, Hang Fan, Bing Yu
This review highlights the recent advances in photoinduced palladium-catalyzed cyclization reactions, categorized by distinct mechanistic pathways.
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Practical and robust access to enimides via the DMAPO-catalyzed coupling of carboxylic acids with secondary enamides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00367B, Paper

Xianghe Wu, Feng Yu, Li Zhang, Yewen Fang
Modular access to α-(hetero)aryl N-vinylimides has been realized via the reactions of N-vinylamides with various (hetero)aryl or aliphatic carboxylic acids enabled by a DMAPO/Boc₂O system.
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Synthesis of the conjugation-ready β-D-rhamnose- and β-D-mannose-containing trisaccharide O-antigen from Serratia spp. strains 10.1WK and 1XS

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00268D, Paper

Sanajit Maiti, Akash Patra, Balaram Mukhopadhyay
Synthesis of the target trisaccharide O-antigen has been accomplished by following a linear strategy.
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Acid-catalyzed divergent synthesis of 2-substituted 1,3-benzazoles with antioxidant and mitochondrial protective effects

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D5OB01959A, Paper

Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Kalleshappa Sharath, Aishwarya Bharathi H M, Prabitha Prabhakaran, Maralinganadoddi P. Sadashiva
Acid-catalyzed annulation of alkyl/arylmethyl thiooxamates with o-aminoaryl precursors enables metal-free synthesis of 2-substituted 1,3-benzazoles in good yields; compound 4i shows favorable mitochondrial-protective and antioxidant activity.
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Advances in the Synthesis of Symmetric 1,3,5-Triazines: Catalysis and Mechanistic Pathways

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00075D, Review Article

Kamal Kant, Thounaojam A Devi, Ahanthem Sonia, Singamayum Rabia, John Laishram, Chandi C. Malakar
Triazines are nitrogen-containing heterocycles that have a variety of applications as building blocks or catalysts in organic synthesis, material science, analytic chemistry, and also in pharmaceuticals. The 1,3,5-triazines, due to...
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Identification and characterization of three strictosidine synthases in Nauclea orientalis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00144K, Paper

Chentao Wei, Pengzhen Bao, Jianyu Gao, Zhiyin Yu, Jing Yang, Jian-Ping Huang, Sheng-Xiong Huang, Zhengjia Wang, Yin Chen, Yong-Jiang Wang
Enzymes for strictosidine biosynthesis in Nauclea orientalis were identified: NoLAMT1 methylates loganic acid to loganin, NoSLS1 oxidizes loganin to secologanin, and NoSTR1–3 condense secologanin with tryptamine to form strictosidine.
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Stereodivergent Photooxidative Synthesis of Cyclocariols A, B, and E from Ginsenoside Rg1

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00346J, Communication

Jie Yuan, Shaomin Fu, Bo Liu
We report a stereodivergent photooxidative synthesis of the 3,4-seco-dammarane triterpenoids cyclocariols A, B, and E from the commercially available ginsenoside Rg1. This study features a visible-light-induced β-fragmentation/elimination cascade reaction that...
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Iodine-catalyzed isomerization of enamides

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00155F, Communication

Yuntao Yuan, Wenhao Wang, Yong Wang, Daming Feng, Shiyong Peng, Chunhua Ge, Peng Huang
A highly efficient and practical iodine-catalyzed Z-to-E isomerization of enamides under mild conditions is developed. The method exhibits broad substrate scope. Its synthetic utility is demonstrated by gram-scale synthesis and...
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Design and synthesis of thiophene-based C2-symmetric chiral phosphoric acids on a decahydroquinoxaline scaffold for stereoselective transformations

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00309E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Margherita Gazzotti, Vincenzo Mirco Abbinante, Fabrizio Medici, Sara Ghirardi, Sergio Rossi, Tiziana Benincori, Roberto Cirilli, Maurizio Benaglia
In this study, the design and the synthesis of a thiophene-based phosphoric acid based on a chiral decahydroquinoxaline scaffold derived from enantiopure trans-1,2-diaminocyclohexane was reported.
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Investigating tedizolid analogues as a new class of herbicides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00242K, Communication

Caleb Hewlett, Aleksandra W. Debowski, Karen J. Deane, Keith A. Stubbs
Tedizolid, an oxazolidinone antibiotic, is herbicidal. A series of functionalised 1,2,3-triazole analogues were synthesised and evaluated, and showed that separation of antibacterial and herbicidal activities is possible.
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Expediated synthesis of N-acyl-N-alkyl sulfonamide probes for protein proximity labelling

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00339G, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Phathutshedzo Masithi, Laetitia Raynal, Peter O'Brien, Christopher D. Spicer
A streamlined synthetic route to access N-acyl-N-sulfonamide (NASA) probes for protein labelling has been developed.
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Rh(III)-catalyzed cascade C–H activation/amination enables the synthesis of 1,2-disubstituted benzimidazoles from amidines and arynes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00074F, Communication

Fen Xu, Shi-Yu Zhang, Jia-Qi Huo, Fan-Wang Zeng, Fu-Kang Zhou, Luciano Barboni
A novel Rh(III)-catalyzed cascade C–H activation/amination between amidines and arynes has been achieved, enabled by the synergy of transition-metal-catalyzed C–H activation and the high reactivity of aryne intermediates.
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Cycloaddition of benzo[d]thiazoles with imidazol-4-one-activated donor–acceptor cyclopropanes: synthesis of spirocyclic inhibitors of HIV-1

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00180G, Communication

Viktoria A. Ikonnikova, Olga E. Shchigal, Andrey N. Anisenko, Pavel N. Solyev, Grigory A. Krylkov, Alexander R. Romanenko, Alexander A. Korlyukov, Mikhail S. Baranov, Marina B. Gottikh, Andrey A. Mikhaylov
Cycloaddition of imidazole-4-one-activated donor–acceptor cyclopropanes with benzo[d]thiazoles affords spirocyclic scaffolds with potential for inhibiting HIV-1 replication.
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Rapid catalyst-free synthesis of α-selenomethyl ketones from sulfoxonium ylides and selenols

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00428H, Paper

Xuyang Gong, Huaiyu Huang, Taiwen Li, Qichen Liu, Xiaoqiong Fu, Haifeng Wang, Hao Zhou, Shuangxi Gu
This catalyst-free protocol enables direct access to antifungal α-arylselenomethyl ketones via mild and operationally simple coupling of sulfoxonium ylides with benzeneselenol.
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Discovery of artemargyins A–E: rare 9′-nor-dibenzylbutane lignans and a lignan–coumarin hybrid with anti-hepatic fibrosis activities from Artemisia argyi var. gracilis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00214E, Paper

Ying Wu, Ze Ma, Yong-Xiang Huang, Tian-Ze Li, Yong-Cui Wang, Ji-Jun Chen
A rare 9′-nor-dibenzylbutane lignan, artemargyin A (1), was isolated from Artemisia argyi var. gracilis, and it demonstrated marked anti-hepatic fibrosis activity.
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Electrochemical regioselective C-3 amination of imidazo[1,2-a]pyridines with electron-deficient sulfonimides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00273K, Paper

Wenji Zhang, Kaiye Wu, Changdi Zheng, Guan Wang, Weihui Zhong, Fei Ling
We presented a metal free electrochemically enabled regioselective C-3 amination of imidazo[1,2-a]pyridines with electron-deficient sulfonimides.
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Progress in intermolecular radical umpolung addition to alkenes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00278A, Review Article

Yeming Wang, Chaoqun Zhang, Jian-Quan Liu
Summarizing recent advances in intermolecular umpolung radical (α-carbonyl, α-sulfonyl, and acyl radical) addition to alkenes.
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Alcohol Mediated Isocyanide Domino Reactions Toward 2-Aminofuronaphthoquinones

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D5OB02014J, Paper

Pedro Martin-Acosta, Maksim Bratukhin, Ana Estévez-Braun
An unprecedented alcohol mediated formation of 2-amino-naphtho[2,3-b]furan-4,9-dione derivatives from 2-hydroxy-1,4-naphthoquinones and isocyanides under microwave irradiation in the presence of Yb(OTf)3 is reported. The effect of different alcohol media, isocyanides and...
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Late-Stage Peptide Nitroarylation: Stereoelectronic Tuning and Molecular Recognition

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00394J, Paper

Jenna Cain, Moira C Dowling, Magdalena C DiGiorno, Ashley M Banaszek, Nicholas Sawyer
Aromatic amino acids lie at the center of protein folding and interactions. For the three aromatic amino acids commonly found in proteins–phenylalanine (Phe), tyrosine (Tyr), and tryptophan (Trp)–their large size...
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Harnessing the Magic Methyl Effect: A Rhodium-Catalyzed Switchable Chemoselective Synthesis of Isocoumarins and Isoquinolines

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00258G, Communication

Bedadyuti Vedvyas Pati, Smruti Ranjan Mohanty, Lamphiza O. Najiar, Subhrakant Jena, Tanmayee Nanda, Himansu S. Biswal, Ponneri C. Ravikumar
We report herein a Rh(III)-catalyzed methyl group controlled switchable synthesis of isocoumarin and isoquinoline. The protocol tolerates a wide range of functionality. Various mechanistic studies, including deuterium labeling, KIE, and...
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Photochemical trifluoromethylation of unactivated alkenes with trifluoromethylsulfonyl-pyridinium salt via remote quinazolinones migration under catalyst free conditions

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00251J, Paper

Qianqian Feng, Jie Hu, Yanmei Che, Sibo Zhai, Xia Zhao, Kui Lu
A novel photochemical trifluoromethylation method has been developed for the functionalization of unactivated alkenes. This approach employs trifluoromethylsulfonyl-pyridinium salt as the trifluoromethyl radical precursor, achieved through a photo redox pathway....
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A tetrazine-driven photocatalytic system suitable for the synthesis of unstable 2,3-dihydroisoxazoles

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00259E, Paper

Tiantian Chen, Zijian Yuan, Shuo Wang, Jianchun Wang
A novel visible-light-driven [3 + 2] cycloaddition reaction of nitrones with alkynyl esters, catalyzed by 3,6-di(pyridin-2-yl)-1,2,4,5-tetrazine (pytz), has been investigated. This reaction effectively synthesizes unstable 2,3-dihydroisoxazole derivatives with yields reaching...
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Photocaging the C6 Carboxylate of β-Glucuronide Prodrugs Enables Spatiotemporally Controlled Release of Anticancer Agents via a Dual Activation Strategy

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00139D, Paper

Junjie Fu, Dianya Yong, Jie Liu, Yunying Tan, Hongyu Yang, Jing Hu, Jian Yin
Traditional β-glucuronide prodrugs are limited by high hydrophilicity which hinders cellular uptake, and by insufficient extracellular enzyme levels which restrict effective drug release. To address these bottlenecks, we developed a...
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"Click" Chemistry for the Assembly of Entirely Carbohydrate-based Vaccines

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00208K, Paper

Geraud Valentin, Andhina Satriani, Matthew Lohman, Peter R Andreana
The immunogenicity of conjugate vaccines is affected by the type of linker used. Due to its ease of synthesis, the "click" triazole linker is now widely used, but its impact...
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Late-stage chirality generation strategies for the total synthesis of macrocyclic natural products

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00160B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Haruhiko Fuwa, Mina Tateya
The development of late-stage chirality generation strategies represents an emerging frontier in the total synthesis of complex macrocyclic natural products.
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Macrocyclic oxygen transfer in conversion of fatty acid hydroperoxide to a single species of triol in physiological saline

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00371K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Min Suk Choi, William E. Boeglin, Donald Stec, M. Wade Calcutt, N. A. Porter, Alan R. Brash
We analyzed the autoxidation and non-enzymic reactions of the 17S-hydroperoxide of docosahexaenoic acid 1, a common lipoxygenase product in mammalian cells and with its six double bonds presenting opportunities for...
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Potassium Hydrogen Sulfate Promoted One-pot Synthesis of Bis(indolyl)alkane Esters from α-Keto Carboxylic Acids: In Silico and In Vitro Anticancer Studies

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00318D, Paper

Trinadh Ballanki, Anjali Devi Subramanian, Pravin Chinnappa, Vaishnu Suresh Kumar, Mohit Garg, Haribabu Jebiti, Daniel Moraga, Baby Viswambharan
Sustainable and efficient synthetic strategies for bioactive bis and tris(indolyl) alkane (BIM and TIM) derivatives remain a central challenge because of their acid sensitivity. Herein, we demonstrate an eco-friendly synthesis...
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Palladium-Catalyzed Defluorinative Coupling of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: Direct Access to Functionalized α-Fluoroenones

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00246C, Communication

Chunming Chen, Huixuan Zhu, Zhengli Luo, Jinhui Hu, Zhuang Xiong, Fucheng Zhou, Jiaqiang Wu
A palladium-catalyzed defluorinative coupling of indoles with α,α-difluoro-β,γ-unsaturated ketones is reported.This method provides direct access to a diverse range of functionalized (Z)-α-fluoroenones in moderate to excellent yields under mild conditions....
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Metabolic labeling and imaging of native Saccharomyces cerevisiae glycan by using N-acetylglucosamine-6-phosphate analogs

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00192K, Paper

Nianci Li, Jiaxin Feng, Shuhui Ji, Bin Fu, Hui Zhang, Tianyou Jiao, Qichan Yi, Nicholas Gong, Yimei Guo, Huijuan Ji, Yishu Yan, Pan Zhu, Jialin Liu, Yuntao Zhu
Synthetic N-azidoacetylglucosamine-6-phosphate analogs can be metabolically incorporated into N-linked glycans and chitin in native Saccharomyces cerevisiae, highlighting their potential applications in glycan imaging and glycoproteomics research.
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Metal triflimide-mediated acylation of sulfonamides and transacylation of N-acylsulfonamides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00269B, Paper

Shimin Yang, Ying Peng, Shujie Li, Juan Tian, Dayong Sang
A method has been developed for preparing N-acylsulfonamides via a metal triflimide-catalyzed acylation of sulfonamides and transacylation of N-acylsulfonamides.
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tert-Butanol as an isobutene equivalent in the IED-HDA reaction of in situ-generated oxindole-embedded o-QMs

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00274A, Paper

Jia-Cheng Ge, Xiangyun Kong, Yao-Bin Shen, Fangzhi Hu, Li-Jun Peng, Shuai-Shuai Li
An FeCl₃-promoted aerobic IED-HDA reaction of in situ-generated oxindole-embedded o-QMs has been reported, in which tert-butanol serves as an ideal equivalent of gaseous isobutene, enabling efficient access to 2,2-dimethylchromane spirooxindoles.
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KBr-Enabled electrochemical transformation of alkynes into α-bromoketones/1,2-diketones

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00329J, Communication

Yulin Li, Siyu Lei, Yuexia Zhang
In recognition of the crucial role of ketone motifs in significant organic transformations and the synthesis of valuable molecules (e.g., pharmaceuticals, pesticides, and fine chemicals), we herein report an electrochemical...
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Ultrafast fluorescent detection of mercury(II) ions in aqueous and biological systems using a boronic acid-based reaction probe

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00170J, Paper

Open Access

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Kishor Khadka, Sumita Subedi, Eun-Taex Oh, Keun-Hyeung Lee
A phenylboronic acid-based fluorescent probe enables rapid fluorescence detection of Hg²⁺ by an irreversible reaction between Hg²⁺ and a phenylboronic acid moiety via a unique intermolecular self-activation mechanism.
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Pyromellitic dihydrazides as hydrolytically stable analogs of pyromellitic diimide

Org. Biomol. Chem., 2026, 24,2650-2654
DOI: 10.1039/D6OB00281A, Communication

Journey M. Amundson, Ryan B. Brush, Kara M. Jensen, Baela R. Funk, Healeam Jung, Sam K. Mamicha, Victor G. Young, Eryck Garcia L., Liana M. Klivansky, Dennis D. Cao
Pyromellitic dihydrazide is a significant upgrade to pyromellitic diimides, combining ease-of-synthesis, extreme alkaline stability, and thermal and structural features together into a new scaffold that is attractive for robust materials.
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Solvated electron-driven hydroamination of olefins

Org. Biomol. Chem., 2026, 24,2717-2724
DOI: 10.1039/D5OB01936B, Paper

Open Access

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Anietie W. Williams, Kerry M. Gilmore
We report a transition metal-free method for the intermolecular hydroamination of olefins using solvated electrons, generated in situ from granulated lithium under sonication in 2-methyltetrahydrofuran (2-MeTHF).
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Iodine-mediated cascade amination enables one-pot access to antimicrobial indole-embedded dihydropyrazoles

Org. Biomol. Chem., 2026, 24,2676-2682
DOI: 10.1039/D6OB00043F, Communication

M. S. Ajay Krishna, K. T. Ashitha, Meghashyama Prabhakara Bhat, Muthuraj Rudrappa, C. S. Athira, A. L. Lalshikanther Basha, Sunil Varughese, Naveen Vankadari, Sreenivasa Nayaka, Sasidhar B. Somappa
A metal-free, iodine-mediated amination enables a one-pot synthesis of indole-embedded dihydropyrazoles with a broad substrate scope.
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Lewis acid-mediated formamidation employing carbohydrates as synthons

Org. Biomol. Chem., 2026, 24,2669-2675
DOI: 10.1039/D6OB00174B, Communication

Yanyu Li, Wenbin Zhang, Zhichao Zhang, Xiulin Li, Qianqian Liang, Yaru Liu, Guoying Zhang
A Lewis acid-catalyzed method enables oxidative C–C formation via concurrent C–H activation and N-formamidation, using air as the sole oxidant and achieving a high turnover number.
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Glycosyl modified nucleoside motifs for glycoconjugation of oligonucleotides

Org. Biomol. Chem., 2026, 24,2640-2644
DOI: 10.1039/D5OB01901J, Communication

Biju Majumdar, Haythem Abda, Henri Barry, Julien Verget, Lea Mulot, Helene Pereira, Corinne Arpin, Alexandra Gaubert, Patricia Korczak, Brune Vialet, Tina Kauss, Philippe Barthélémy
This study presents a simple phosphoramidite-based strategy using glycosylated nucleoside phosphoramidites to efficiently synthesize a wide diversity of carbohydrate–oligonucleotide conjugates directly during solid-phase oligonucleotide assembly.
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Tunable synthesis of oxindoles and sulfonated oxindoles via photoredox-catalyzed C–H/C–H coupling

Org. Biomol. Chem., 2026, 24,2732-2741
DOI: 10.1039/D6OB00076B, Paper

Qiaomei Zhu, Binjie Liu, Zhihan Hu, Haifeng Hu, Xinlian Huang, Xinyue Jiang, Ping Zhang, Xianwei Sui
A novel photoredox-catalyzed protocol has been developed for the modular construction of 3,3-disubstituted oxindole architectures via one-pot C–H/C–H coupling, enabling efficient arylative and sulfonative transformations in moderate to good yields.
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Efficient one-step synthesis of 3-nitroflavones via cascade nitration-cyclization

Org. Biomol. Chem., 2026, 24,2645-2649
DOI: 10.1039/D6OB00238B, Communication

Yilin Yang, Chukai Shao, Ruirui Hua, Rui Tian, Ziang Wang, Hongquan Yin, Houhua Zhu, Fu-Xue Chen
A cascade nitration-cyclization of alkynyl aryl ketones using 68% HNO₃ and Zn(OTf)₂ enables direct access to 3-nitroflavones at room temperature with high regioselectivity. The products are readily scalable and converted to 3-aminoflavones.
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Divergent assembly of fused polycyclic scaffolds from iodotriazole-tethered benzaldehydes

Org. Biomol. Chem., 2026, 24,2752-2760
DOI: 10.1039/D6OB00280C, Paper

Anfisa L. Shosheva, Roman S. Tatevosian, Gennadij V. Latyshev, Yury N. Kotovshchikov, Nikolay V. Lukashev, Irina P. Beletskaya
5-Iodo-1,2,3-triazoles with pendant aldehyde groups serve as versatile precursors for diverse fused azaheterocyclic scaffolds via the formation of cyclic (hemi)aminals, followed by facile TM-free C(sp²)–N coupling.
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Cationic [1,2]-aryl shift in the design of poly(hetero)aromatic systems: from structure to functional materials

Org. Biomol. Chem., 2026, 24,2626-2639
DOI: 10.1039/D6OB00064A, Review Article

I. S. Mekeda, R. Yu. Balakhonov, V. Z. Shirinian
The [1,2]-aryl shift is of great interest for the modification of poly(hetero)aromatics and is widely used to obtain functional materials and bioactive compounds.
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Diastereoselective oxidative cyclization of 1,4-dienes for the synthesis of oxetanes

Org. Biomol. Chem., 2026, 24,2660-2664
DOI: 10.1039/D6OB00220J, Communication

Shengxin Wang, Yanhua Zhang, Chao Wang, Lili Zong
Osmium catalyzed diastereoselective oxidative cyclization of 1,4-dienes provides a simple method for synthesizing oxetanes, with 4 C–O bonds and the oxetane ring formed in a single step.
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Base-promoted intermolecular cyclization of substituted 3-aryl-3-chloropropenals with tetrahydro-β-carboline: a method for the synthesis of indolizino[8,7-b]indole compounds

Org. Biomol. Chem., 2026, 24,2655-2659
DOI: 10.1039/D6OB00015K, Communication

Kairong Chen, Miao Yang, Shuang Chen, Yanchuan Gong, Junnan Xu, Meixiang Ye, Jie Zhang, Liang Guo
A series of dihydroindolizino[8,7-b]indole derivatives were synthesized via a TEA-promoted one-pot tandem cyclization. Preliminary cytotoxicity assays showed that some compounds exhibited certain inhibitory activities against two lung cell lines.
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Koser's reagent-promoted synthesis of substituted isoxazoles and their photophysical properties

Org. Biomol. Chem., 2026, 24,2742-2751
DOI: 10.1039/D5OB02000J, Paper

Rajnish Budhwan, Pooja Dahiya, Nikunj Singh, Shivom Chauhan, Rama Krishna Peddinti
A Koser’s reagent [PhI(OH)OTs]-mediated oxidative cyclization of arylaldoximes enables transition-metal-free synthesis of diverse isoxazoles and polycyclic isoxazole–quinone hybrids through intermolecular (3 + 2) cycloaddition.
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Annulation of aliphatic nitro compounds with β-styryl sulfonium salts toward the synthesis of isoxazoline N-oxides

Org. Biomol. Chem., 2026, 24,2725-2731
DOI: 10.1039/D6OB00176A, Paper

Pavel Yu. Ushakov, Stepan N. Chichulin, Alexey Yu. Sukhorukov, Andrey A. Tabolin
Annulation of aliphatic nitro compounds with β-styryl sulfonium salts enables effective assembly of isoxazoline N-oxides with a difficult-to-obtain substitution pattern.
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3H-Phenothiazin-3-one: a photocatalyst for the mild oxidation of boronic acids under green LED irradiation

Org. Biomol. Chem., 2026, 24,2696-2702
DOI: 10.1039/D6OB00133E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Constantinos T. Constantinou, Petros L. Gkizis, Dragos F. Flesariu, Stamatis K. Serviou, Georgia A. Zissimou, Panayiotis A. Koutentis, Christoforos G. Kokotos
3H-Phenothiazin-3-one is reported as an efficient photocatalyst for the photochemical oxidation of boronic acids, using green LED irradiation and atmospheric oxygen as the terminal oxidant.
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Palladium-catalyzed 1,4-migration for the regioselective C–H bond functionalization at C2-position of 3-arylthiophenes

Org. Biomol. Chem., 2026, 24,2703-2716
DOI: 10.1039/D6OB00099A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Bo Lan, Norman Le Floch, Henri Doucet
Bromide acts as a traceless directing group, enabling regioselective thienyl C2 heteroarylation via double C–H bond functionalisation.
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Recent progress on thiocarbamates: synthesis and applications

Org. Biomol. Chem., 2026, 24,2613-2625
DOI: 10.1039/D6OB00255B, Review Article

Ao-Cheng Wang, Si-Yu Hu, Xin-Yu Lin, Ning Li, Yong-Ying Cui, Qing-Xin Li, Zhi-Bing Dong
This mini-review summarizes the representative advances in thiocarbamate synthesis over the past decade, covering diverse strategies from thermochemistry to photochemistry and electrochemistry.
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Photo-induced silylation cyclization of indole-tethered 1,6-enynes to access silylated pyrrolo[1,2-a]indole derivatives

Org. Biomol. Chem., 2026, 24,2665-2668
DOI: 10.1039/D6OB00295A, Communication

Jingyi Chen, Lijun Li, Haoran Feng, Zexuan Liu, Xueli Wang, Qinqin Yan, Zejiang Li
Photo-induced silylation annulation of indole-tethered 1,6-enynes provides access to diverse silylated pyrrolo[1,2-a]indoles with good selectivity/yields.
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Dynamic N→B coordination and anion-selective turn-on fluorescence in oxadiazole-functionalized organoboranes

Org. Biomol. Chem., 2026, 24,2683-2695
DOI: 10.1039/D5OB01979F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jonas D. W. Schepper, Andreas Orthaber, Frank Pammer
The proposed method for facile preparation of structurally diverse organoboranes allows incrementally tailoring their electronic properties and Lewis acidity. We identified compounds that show selective fluorescence in the presence of cyanide.
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Acrylamides from alkynes: a synthetic overview

Org. Biomol. Chem., 2026, 24,2592-2612
DOI: 10.1039/D6OB00053C, Review Article

Shivam Bhargav, Akash Singh, Ashirwad Divedi, Anjul Vilas, Preeti Gupta, Jawahar L. Jat
This review outlines recent metal-catalyzed and metal-free methods for synthesizing acrylamides from alkynes, highlighting reaction diversity and advances in regio- and chemoselectivity.
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Synthesis of oxaprozin analogs from 2H-azirines and cyclic anhydrides

Org. Biomol. Chem., 2026, 24,2761-2767
DOI: 10.1039/D6OB00168H, Paper

Reyhaneh Azimi, Kamran Amiri, S. Sina Hosseini, Robert Stranger, Alireza Ariafard, Frank Rominger, Hamid Reza Bijanzadeh, Saeed Balalaie
The cascade reaction of 2H-azirines with cyclic anhydrides to form oxaprozin analogs is catalyzed by a dicarboxylic acid formed via partial anhydride hydrolysis. DFT calculations support the proposed mechanism.
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Enantioselective synthesis of chiral organoborons via carbene B-H insertion catalyzed by engineered neuroglobin

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00282J, Communication

Xin Shan, Lijuan Sun, Huamin Wang, Shu-Qin Gao, Ying-Wu Lin
The heme-containing globin, neuroglobin (Ngb), was engineered to catalyze enantioselective carbene B-H insertion reaction, affording chiral organoboron compounds up to 66% yield and 97:3 e.r. The rationally designed quadruple mutant,...
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Photocatalytic C–H amination of electron-rich arenes by novel fused quinoline-based photocatalysts

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00270F, Paper

Qian Shu, Dinghao Li, Siyu Zheng, Xue-Lian Lu, Bing Sun, Fang-Lin Zhang
A range of fused quinoline-based photocatalysts were designed via the Povarov reaction. Upon in situ protonation with protic acid, these photocatalysts catalyze the C(sp²)–H amination of electron-rich arenes with azoles.
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Photoinduced FeCl₃-Catalyzed α-C(sp³)-H Azolation of Primary Aliphatic Alcohols via LMCT-Driven HAT

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00200E, Paper

Weikun Zeng, Shuyan Zhan, Rong Huang, Mingquan Yuan, Jianqiang Zhang, Yi Jin
Herein, a visible-light-driven FeCl₃-catalyzed α-C(sp³)-H azolation/coupling reaction of primary aliphatic alcohols has been reported. The reaction achieves activation of the α-C(sp 3 )-H bond in the ether formed by dehydration...
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Design and synthesis of aculeatin oxo-analogues and aculeatin natural products enabled by oxo-carbenium ion cyclization

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00165C, Paper

Manoj Kumar, Shubham Singh, Parthasarathi Subramanian
PIDA-mediated dearomatization of phenols generates a transient spiroacetal oxo carbenium ion that reacts with diols to form aculeatin oxo-analogs. The intramolecular protocol improves efficiency and enables the total synthesis of aculeatins.
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Catalyst-free facile synthesis of 2-(dihydropyridyl)benzothiazoles from (benzothiazol-2-yl)acrylonitriles: green route

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00288A, Communication

Nikunj Singh, Rajnish Budhwan, Megha Rawat, Rama Krishna Peddinti
We report an efficient, metal- and catalyst-free [3 + 3] annulation reaction to synthesize 2-(dihydropyridyl)benzothiazoles and related imidazo-, pyrimidino-, and diazapino[1,2-a]dihydropyridyl benzothiazole analogues.
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Viscosity-responsive styryl benzoxazole probes for lipid droplet visualization

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00086J, Paper

Vijay Sai Krishna Cheerala, Simran, Prateek Sarkar, Deeksha Rajput, Sriram Kanvah
Rapid synthesis of styryl benzoxazole dyes yields bright probes that selectively label lipid droplets in live cells. Sensitivity to viscosity and electronic effects reveals clear structure–property relationships for bioimaging design.
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Electrochemical direct site-selective selenation of carbazoles

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00206D, Paper

Haodong Ma, Wei Xu, Haomin Chen, Bin Wang, Ziren Chen, Yu Xia, Shaofeng Wu, Weiwei Jin, Chenjiang Liu, Yonghong Zhang
An electrochemical direct site-selective selenation of carbazoles has been developed.
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Microwave-assisted, acetic acid-catalyzed, metal-free synthesis of 5H-pyrazino[2,3-b]indoles via sequential C–C and C–N bond formation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00100A, Paper

Tiyasa Dhar, Debasish Bera, Supriyo Halder, Chhanda Mukhopadhyay
This study introduces a synthetic method to obtain 5H-pyrazino[2,3-b]indoles through acetic acid catalyzed sequential C–C and C–N bond formation under microwave irradiation.
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Development of a convenient and useful transesterification reaction using a catalytic amount of strontium alkoxide

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00072J, Communication

Chisato Kamada, Ryosuke Shimoda, Masaharu Ueno, Norikazu Miyoshi
Strontium tert-butoxide is an easily prepared, shelf-stable white solid that efficiently catalyzes solvent-free transesterification of various methyl esters with alcohols, giving excellent yields.
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Palladium-catalyzed enantioselective decarboxylative [3 + 2] cycloaddition of 5-vinyloxazolidine-2,4-diones with sterically encumbered ketoimines toward chiral polycyclic 1,4-imidazolidinones

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00235H, Communication

Juan Liao, Wei Sun, Guo-Yin Sun, Xue-Song Peng, Lei Yang, Yong You, Zhen-Hua Wang, Jian-Qiang Zhao, Ming-Qiang Zhou, Wei-Cheng Yuan
A palladium-catalyzed asymmetric decarboxylative [3 + 2] cycloaddition of 5-vinyloxazolidine-2,4-diones with cyclic N-sulfonyl ketoimines was developed to access polycyclic 1,4-imidazolidinone derivative with good to excellent stereoselectivities.
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Pyridine-boryl radical-mediated reductive homocoupling of para-quinone methides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00078A, Paper

Yan-Zhao Cui, He Li, Huiyi Liu, Hao-Qi Yuan, Hao-Tian Zhou, Xiao-Sai Wang, Yan-Bo Wang
An effective and straightforward metal-free reductive homocoupling of para-quinone methides was developed, affording a broad range of differently substituted tetraarylethanes.
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Catalyst- and additive-free reduction of carboxylic acids and amides using ammonia borane as a hydrogen source

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00293E, Communication

Wanzhen Guo, Xing Lu, Hui Zhou, Nana Wei, Xin Liu, Zhiqiang Ren, Bo Han
We report a cost-effective, safe, sustainable, and environmentally friendly strategy for the efficient and selective reduction of carboxylic acids and amides using ammonia borane as a hydrogen source without the use of catalysts and additives.
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Application of the intramolecular Diels–Alder vinylarene (IMDAV) reaction for the synthesis of benzo- and carbocyclofuroisoindole carboxylic acids and its limitations

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D5OB01918D, Paper

Elizaveta D. Yakovleva, Evgeniya R. Shelukho, Pavel P. Erokhin, Valentina V. Ilyushenkova, Aleksandra S. Guryeva, Nikita A. Logvinenko, Victor N. Khrustalev, Mikhail S. Grigoriev, Fedor I. Zubkov, Vladimir P. Zaytsev
A concise preparative IMDAV strategy for the synthesis of benzo- and carbocyclofuroisoindole carboxylic acids starting from readily available materials was proposed.
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Synthesis of tri-substituted, aliphatic and 13C-labelled α,β-unsaturated carboxylic acids via Wittig CO2 utilisation reactions

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00221H, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Rachel E. Lynch, Amy Lowry, Gerard P. McGlacken, Peter A. Byrne
Wittig CO₂ utilisation reactions enable rapid construction of α,β-unsaturated carboxylic acids, with regioselective installation of both the carboxyl and alkene groups, and out-compete aldol self-condensation reactions for aliphatic aldehydes.
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Recent developments in asymmetric synthesis of cyclohepta[b]indole derivatives

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00275G, Review Article

Reena Jangir, Jyothi Yadav, Eldhose Iype, Sravendra Rana, Indresh Kumar
This review article covers the current state of asymmetric synthetic methods for functionalized cyclohepta[b]indoles, which have attracted significant interest due to their presence in many bioactive compounds.
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Water-soluble squaramide functionalised peptides for sulfate recognition in aqueous media

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00302H, Paper

Nikki A. Tzioumis, Katrina A. Jolliffe
Flexible peptidic receptors selectively bind sulfate ions in highly competitive aqueous mixtures through a combination of side chain and backbone hydrogen bonding interactions.
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Facile synthesis of redox-responsive peptide coacervates for cytosolic protein delivery

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00358C, Paper

Xiaona Han, Ruihui Han, Jiaxin Yang, Xiao Hua, Yi-Ming Li
Backbone disulfide design enables facile synthesis of redox-responsive peptide coacervates for protein delivery.
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Cyclisations and hydrolysis of geranyl and farnesyl halides in water facilitated by ultrasound-induced emulsification

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D5OB01695A, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jan Luca Budde, Andreas Kirschning, Gerald Dräger
How stable are geranyl and farnesyl halides in water?
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Chemoselective transfer hydrogenation of alkynoates enabled by Cu(I)-photosensitizer catalysis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00115G, Paper

Kun Zhang, Ziwen Huang, Yin Xu, Yunkui Liu
A novel strategy for the transfer hydrogenation of alkynes to alkanes catalyzed by a Cu(I) photosensitizer was developed, providing exclusive chemoselectivity for alkynoates in the presence of electron-neutral alkynes and other reactive motifs.
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SEAr-based reductive arylation of indoles with ketones: skeletal metamorphosis of ketones into aryl architectures

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00161K, Paper

Taiki Sakata, Teruhisa Tsuchimoto
We developed the S_EAr-based reductive arylation of indoles with ketones, which uniquely metamorphosed into aromatic skeletons during the reaction.
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Affinity enhancement of polo-like kinase 1 polo-box domain-binding peptides by N-methylation and lipidation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00193A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kohei Tsuji, Kenan Bai, Xueyuan Huang, Hirokazu Tamamura
Synthesized Plk1 PBD-binding peptides with N-methylation exhibited up to 4-fold improved PBD affinities and with lipidation demonstrated up to 260-fold improved PBD affinities as compared with the parent peptide.
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Betaine–ZnO hybrid catalyst: a sustainable bifunctional system for solvent-free Knoevenagel condensation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00300A, Paper

Lema Deme Shumi, Mateusz Pilszek, Magdalena Grabowska, Sebastian Jurczyk, Dariusz Łukowiec, Piotr Latos
A sustainable betaine–ZnO hybrid catalyst was synthesized via a simple mixing approach between betaine hydrochloride and zinc oxide.
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Recent Advances in Organocatalytic Enantioselective Construction of Alkynyl-Containing Tetrasubstituted Carbon Stereocenters

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00306K, Review Article

Jiaying Yin, Yu Li, Junbing Lin
Alkynyl-containing tetrasubstituted carbon stereocenter represents a frequently encountered structural motif in a series of biologically active molecules. Furthermore, the presence of alkyne-containing tetrasubstituted carbon stereocenters in a molecule offers a...
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Recursive Anionic γ'-Spiro-annulation of Cyclic Vinylogous Esters with 2-Vinylbenzoates

Org. Biomol. Chem., 2025, Accepted Manuscript
DOI: 10.1039/D6OB00163G, Communication

Chia-Chen Chien, Grace Victoria Govada, Li-Ching Shen, Yen-Ku Wu
We report a γ'-selective anionic cascade spiroannulation between cyclic vinylogous esters (CVEs) and 2-vinylbenzoates. This transformation proceeds with high γ'-selectivity, enabling CVEs to function as γ',γ'-dianionic equivalents while engaging 2-vinylbenzoates...
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Photocatalytic α-fluoro-β-phosphonoylation of unsaturated amides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00181E, Paper

Fang Wang, Jie Gong, Wan-Yu Shao, Lu-Yao Lin, Yi-Ming Chen, Yan-Biao Kang, Jian-Ping Qu
A redox-neutral photocatalytic strategy enables the α-fluorination and β-phosphonylation of α,β-unsaturated amides via an organic photocatalyst, CBZ6.
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An organocatalytic enantioselective aza-Henry reaction of pyrazolone ketimines

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00412A, Paper

Yakun Wang, Xiaoyu Du, Han Wang, Xu Kong, Jinghao Tian, Yuli Zhang, Jinying Liang, Pengfei Yang, Tao Zhang
We report an organocatalytic enantioselective aza-Henry reaction of pyrazolone ketimines with nitroalkanes.
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An asymmetric tandem reaction of dicyanoalkenes with conjugated sulfinyl imino esters

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00277C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Francesc Ferrer-Pérez, Marcos Escolano, Daniel Gaviña, Santiago Díaz-Oltra, Amparo Sanz-Marco, María Sánchez-Roselló, Carlos del Pozo
The DBU-mediated tandem reaction of dicyanoalkenes with enantiomerically pure conjugated sulfinyl iminoesters give rise to the formation of tetracyclic scaffolds with formation of 3 bonds and 4 stereocenters in good diastereo- and enantioselectivies.
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Structure–activity relationship of neplanocin A analogues for the identification of novel anti-HBV leads

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00227G, Paper

Ramakrishnamraju Samunuri, Masaaki Toyama, Mohan Kasula, Manda Veerababu, Vigneswara Rao Mallipudi, Ravi Teja Achanta, Venkatachalam Rajeshkumar, Ashok Kumar Jha, Masanori Baba, Mika Okamoto, Ashoke Sharon
Carbasugar-modified neplanocin analogues inhibit HBV replication and provide new leads for antiviral development.
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Synthesis and study of meso-phenothiazinyl 3-pyrrolyl BODIPY and its derivatives

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00126B, Paper

Neha Tripathi, Saitali Laha Roy, Shobhna Kapoor, Mangalampalli Ravikanth
A series of fluorescent meso-phenothiazinyl 3-pyrrolyl BODIPY derivatives were synthesized; the oxidized derivative (3·SO₂) showed negligible cytotoxicity and enhanced lipophilicity, indicating potential as a fluorescent imaging probe.
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Correction: Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition

Org. Biomol. Chem., 2026, 24,2580-2580
DOI: 10.1039/D6OB90028C, Correction

Open Access

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Astha M. Dwivedi, Raymond J. Butcher, Ashutosh V. Bedekar
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Peptide-directed solid-phase reductive amination

Org. Biomol. Chem., 2026, 24,2559-2569
DOI: 10.1039/D6OB00034G, Paper

Open Access

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Maria Grigoropoulou, Dimitrios Tolis, Evrydiki Nierri, Angeliki Georgia Mandrapylia, Dimitrios Gatos, Kleomenis Barlos, Spyridon Mourtas
Solid-phase reductive amination of C-terminal peptide α-amino aldehydes enables amide-to-Ψ[CH₂–NH] replacement with controllable racemization.
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Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors

Org. Biomol. Chem., 2026, 24,2542-2558
DOI: 10.1039/D5OB01897H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Arun K. Ghosh, Amlan Bhattacharjee, Uttara Jayashankar, Sydney N. Bogan, Andrew D. Mesecar
Diastereoselective Ugi-multicomponent reactions (Ugi-MCR) are investigated. These reactions provided bis-amides up to 91 : 9 dr and moderate to good yields.
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Decarboxylative Giese additions through electron donor–acceptor complexes under transition metal-free conditions

Org. Biomol. Chem., 2026, 24,2575-2579
DOI: 10.1039/D5OB02007G, Paper

Hao Tian, Cai-Ling Xu, Yi-Fang Li, Yong-Heng Wang, Gen-Long Jiao, Hao Gao, Rong-Rong He
Herein, we describe a metal-free Giese addition reaction method based on RAEs/HEH complexes under thermal conditions. The excellent tolerance to water and oxygen makes this method highly suitable for late-stage modification.
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Environmentally benign esterification and disproportionation using activation of acid anhydrides by molecular sieves 3A

Org. Biomol. Chem., 2026, 24,2570-2574
DOI: 10.1039/D6OB00088F, Paper

Nana Hatayama, Yuna Yoshioka, Nagatoshi Nishiwaki
The carbonyl group of an acid anhydride was activated by molecular sieves 3A, enabling nucleophilic substitution with an O-nucleophile under mild conditions even in the absence of any catalyst and without the formation of detectable byproducts.
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Access to S,C-sulfonium ylides from iodonium ylides via iron catalysis

Org. Biomol. Chem., 2026, 24,2423-2427
DOI: 10.1039/D6OB00230G, Communication

Wanqi Hu, Xingyu Chen, Xiaowei Wu
Iron-catalyzed transylidation enables a mild, sustainable route to S,C-sulfonium ylides from sulfides and iodonium ylides. This efficient, broadly applicable method offers a practical method for constructing valuable sulfur-based building blocks.
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Transaminase-triggered synthesis of 2,5-disubstituted pyrrolidines

Org. Biomol. Chem., 2026, 24,2435-2438
DOI: 10.1039/D6OB00264A, Communication

Open Access

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Aoife Martin, Lisa Kennedy, Ishita Solanki, Patricia Fleming, Julia Bruno, Paul Evans, Marianne Bore Haarr, Elaine O'Reilly
2,5-Disubstituted pyrrolidines were synthesised from ketoenone substrates using a transaminase-triggered intramolecular aza-Michael reaction in moderate to good yields. The dynamic pyrrolidines were stereoselectively resolved by chemical nosylation.
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Facile one-pot synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines

Org. Biomol. Chem., 2026, 24,2522-2531
DOI: 10.1039/D5OB01892G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Esra Korkmaz Yurtoglu, Metin Zora
A new methodology for the synthesis of unknown 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines is reported through the intramolecular cyclization of linear bis-α,β-alkynic ketone precursors via an imidazoline intermediate.
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