RSC - Org. Biomol. Chem. latest articles

Enzyme-catalysed synthesis of pyridines from biomass-derived feedstocks

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00839A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Victoria Sodré, Goran M.M. Rashid, Boriana V. Yotzova, Timothy D.H. Bugg
Pyridines are found in many pharmaceuticals and agrochemicals, but are synthesised from fossil fuel conversion. 2,4- and 2,5-Pyridinedicarboxylic acids have been reported as products from bioconversion of renewable lignin feedstocks...
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Catalytic Regioselective Alkylation of Oxindoles Using diaryl Secondary Alcohols under Homogeneous Conditions

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00687F, Paper

Chibisree Elanchezhian, Nandana Mohan, Mrinal Kanti Das, Saikat Chaudhuri
A homogeneous DABCO(TfOH)₂-catalyzed protocol has been developed for the regioselective alkylation of 2-oxindoles using secondary alcohols under mild conditions. The transformation proceeds efficiently in HFIP through effective activation of the...
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Palladium-catalyzed Synthesis of S-Aryl Thiocarbamate via Desulfurative C-S Cross-coupling Reaction of Dithiocarbamates

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00331A, Paper

Rahul Mondal, Manas Mondal, Amit Saha
A new protocol for synthesizing S-aryl thiocarbamate has been demonstrated here by the desulfurative C-S cross coupling of dithiocarbamate esters with arylsilanes in presence of Pd(II)-catalyst and Cu(II)-oxidant. A series...
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Metalloradical and photoredox manifolds in manganese photocatalysis

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00695G, Review Article

Maulik Pethani, Yash Dhaduk, Shivam Vispute, Anilkumar Kommoju, Shreeya Dave, Arpan Patel, Kishor Padala, Togati Naveen
Visible-light-driven manganese catalysis has emerged as a powerful and sustainable alternative to noble-metal-based photoredox systems. Owing to its abundance on Earth, low toxicity, and rich redox flexibility, manganese enables a...
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Synthesis of meta-substituted phenols and 1-estradiol conjugated analogues of suberoylanilide hydroxamic acid (SAHA)

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00599C, Paper

Chanoknun Boonyaratsewee, Kitiya Rujimongkon, Wannarasmi Ketchart, Somsak Pianwanit, Yongsak Sritana-Anant
Estradiol conjugated drugs are one of the prime targets toward developing into new treatments of hormone-responsive types of cancer. Due to the overexpression of estrogen receptor (ER) in breast cancer...
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Distinct Reactivity of Aromatic and Aliphatic Thiols for the Efficient Synthesis of Chromeno[2,3-d]pyrimidine and Chromeno[4,3-b]chromene Derivatives: Mechanistic Investigations and Reaction Scope

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00585C, Communication

Suman Sourabh, Yogesh Bhaskar Singh Tanwer, Raj Rani, Sabyasachi Bhunia, Sanchari Pal, Debjit Das
In this study, an efficient and convenient three/two-component cyclization protocol is presented for the development of synthetically valuable chromeno[2,3‐d]pyrimidine derivatives via pTSA-catalyzed reaction of substituted salicylaldehyde, 1,3-dimethylbarbituric acid, and both...
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Synthesis of aza-β-lactams via B(C6F5)3-catalyzed Wolff rearrangement/[2+2] cascade cyclization of α-diazoketones with diazenes

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00455E, Paper

Weihong Song, Yu-xiao Ye, Jing-dong Wu, Jun-Jie Li, Xiao-Mei Jiang, Rong-bin Zhao, Wei-Guo Yu, Ziwei Xiang
The development of efficient, metal-free routes to aza-β-lactams is a significant pursuit in synthetic and medicinal chemistry. Herein, we report a novel, one-pot cascade strategy for the synthesis of aza-β-lactams...
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Imine bond protection by supramolecular encapsulation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00736H, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Kejia Shi, Bradley D. Smith
In aqueous media, an imine bond is hydrolyzed very rapidly, however, it can be protected and stabilized when encapsulated by a suitable host molecule.
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Synthesis of 3′-deoxy-4′-thionucleosides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00725B, Paper

Yoshihiro Natori, Aya Itoh, Momoko Adachi, Hideaki Wakamatsu, Yukako Saito, Asako Kaise, Yuichi Yoshimura
Synthesis of 3′-deoxy-4′-thionucleosides was accomplished utilizing a key tandem S_N2 reaction.
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Dehydrogenative cycloisomerization–arylation reaction of N-propargyl carboxamides by iodine(III) catalysis using activated sulfoxide

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00564K, Paper

Miwa Shoji, Yuki Umakoshi, Yuto Iwanami, Akira Tsubouchi, Akira Yoshimura, Akio Saito
Hypervalent iodine(III) catalysis using an oxidation system that is less expensive than conventional methods enables cycloisomerization–arylation reactions with a wide range of aromatic compounds.
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Synthesis of uniflorol B, a chromanone metabolite of Calea uniflora, and investigation of novel analogues as anti-leishmanial agents

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00708B, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Luana Budny Niero, Daniela Pagliara Lage, Eduardo Antonio Ferraz Coelho, Ricardo Andrez Machado-de-Avila, James W. Barlow, Patricia de Aguiar Amaral, Nicolas Gouault
In this work, we report the first synthesis of the anti-leishmanial natural product uniflorol B. Uniflorol B is a chromanone metabolite first isolated from the Brazilian medicinal plant Calea uniflora Less. and possesses anti-leishmanial activity.
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Rongalite-mediated hydride-free chemoselective reduction of the CC bond of isatin-derived Michael acceptors

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00572A, Paper

Suryakant S. Chaudhari, Chandrakant B. Nichinde, Baliram R. Patil, Anil K. Kinage
Rongalite promotes a metal-, hydride-, and visible-light-free chemoselective reduction of isatin-derived Michael acceptors to 3-substituted 2-oxindoles under ambient conditions, with excellent scalability and favorable green chemistry metrics.
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C-terminally engineered nucleopeptide-based soft materials exhibiting antibacterial and antifungal efficacy against multi-drug-resistant strains

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00700G, Paper

Swapnendu Deb, Shreya Ghosh, Sudipta Sarkar, Supratim Bose, Sandipan Chatterjee, Arindam Banerjee
Three self-assembled C-terminally modulated thymine containing nucleopeptides show potential antibacterial and antifungal activities with non-significant cytotoxicity to human cells.
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Metal-Ligand Cooperative Ni(II) Catalysis for One-Pot Access of Biologically Relevant Quinolines and Their Transfer Hydrogenation

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00303F, Paper

Virendra Kumar Chaudhary, Keshav Sharma, Prashant Kukreti, Sain Singh, Kaushik Ghosh
Herein, we present a square planar Ni(II) cooperative catalyst affixed by azo- and amido-based ligand that has been effectively employed for accessing highly substituted quinolines utilizing 2-aminoaryl alcohols with 2°-alcohols....
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Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00643D, Paper

Feng Chen, Zhiqin Zhang, Jianwei Wang, Jiaxi Xu, Hongguang Du, Ning Chen
A visible-light-driven, three-component coupling for the synthesis of N-aryl amino acids and unnatural peptides is described, which proceeds under mild, catalyst-and photocatalyst-free conditions-even under natural sunlight. Glyoxylates, anilines, and 4-alkyl...
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Cu-catalyzed oxidative coupling of alkylarenes with tertiary C(sp3)–H bonds via C–H activation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00723F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Gang Hong, Pradip D. Nahide, Wahiduddin G. Patel, Marisa C. Kozlowski
Efficient Cu-catalyzed CDC of alkylarenes with tertiary C(sp³)–H Bonds via C–H activation.
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A Sustainable Photocatalytic Regioselective Halogenation of 1-Alkyl/Benzyl-3-Phenylquinoxalin-2(1H)-ones in Aqueous Media

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00384B, Paper

Monika Monika, Prashant Kumar, Brajendra Kumar Singh
A sustainable and regioselective protocol for mono-halogenation of 3-arylquinoxalin-2(1H)-ones has been developed, utilizing 1,3-dihalo-5,5-dimethylhydantoin derivatives as halogen sources. A dual catalytic system combining Pd(OAc)₂ and water-soluble Eosin Y was employed...
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The Sulfo-Click Reaction: Expanding the Toolbox for Bioconjugation and Medicinal Chemistry

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00609D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Michael Smietana, Romain Amador, Guillaume Clavé
The sulfo-click reaction, which relies on the chemoselective coupling of sulfonyl azides with thioacids to yield Nacylsulfonamides, has emerged as a powerful and versatile transformation in synthetic chemistry and bioconjugation....
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Transition Metal-Free Rongalite-Mediated Geminal C(sp³)–H Functionalization of Fluorenes

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00637J, Paper

Rambabu Kandukuri, Madhu Inapanuri, Nagaraju Naddi, Hari Prasad Kokatla
A transition-metal-free rongalite-mediated strategy has been developed for the geminal difunctionalization of fluorene derivatives, enabling the efficient synthesis of (9-methyl-9H-fluoren-9-yl)methanols derivatives. In this transformation, rongalite plays a dual role as...
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Bioinspired direct diversification of Pinus densiflora resin via an oxa-Diels-Alder reaction and its anti-neuroinflammatory effects in BV2 microglial cells

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00452K, Paper

Van-Hieu Mai, Seri Choi, Yunhui Che, Gi-Hyeon Seong, Jae S Park, Jin-Pyo An, Yun-Sil Lee, Won-Keun Oh
The resin of Pinus densiflora (Pine resin) serves as a natural reservoir rich in abietane-type diterpenoids, a structurally diverse class of secondary metabolites with notable pharmacological potential. To enhance the...
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Synthesis of Enaminones Enabled by Potassium Persulfate Oxidative N-Dealkylation and Addition to Ynones

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00759G, Paper

Yong Xiao, Li-Gang Kou, Bin-Xuan Zou, Qiong Jia, Yong-Qiang Wang
The development of efficient and practical N-dealkylation methods stands as a long-sought goal in synthetic chemistry. Herein, we developed a convenient N-dealkylation reaction of tertiary amines enabled by the oxidation...
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Sortase A-Mediated Hydrazinolysis Generates Homogeneous N-Terminal GL Proteins for OaAEP1-Catalyzed Bioconjugation

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00719H, Paper

Junjiang Li, Tingting Cui, Jian Sun, Yi-Ming Li
OaAEP1-mediated ligation provides an effective platform for site-specific protein modification, but it needs to obtain homogeneous N-terminal Gly-Leu (GL) protein substrates. Here, we describe a Sortase A-mediated hydrazinolysis approach for...
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Efficient and metal-free synthesis of functionalized unsymmetrical pyrrolyl–pyridine boron difluoride fluorophores

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00705H, Paper

Sirimongkon Aryamueang, Panyawut Ranuman, Nutchapong Suwanwong, Watchara Srimontree, Rung-Yi Lai, Anyanee Kamkaew
A rapid, metal-free strategy enables the synthesis of unsymmetrical BOPP fluorophores with tunable emission and large Stokes shifts, offering a versatile platform for next-generation fluorescent materials.
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From one to two CO2 molecules: controllable divergent synthesis of formate esters and carbonates

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00632A, Paper

Qiankai You, Yubing Zhou, Yanwei Ren, Huanfeng Jiang, Chaorong Qi
By precisely modulating reaction conditions, we achieve a controllable reductive functionalization of CO₂, enabling the divergent synthesis of either formate esters or unsymmetrical organic carbonates from CO₂, phenylsilane, and organic halides.
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The enzyme-free regioselective phosphorylation of ribonucleosides is promoted by metal ions

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00404K, Paper

Manick Mistri, Biswarup Jash
We show that transition-metal ions promote the regioselective formation of 2′,3′-cyclic ribonucleotides from nucleosides and phosphate via wet-dry cycle. Our findings offer a potential link to the emergence of RNA chain under early Earth conditions.
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Application of a 1-(2-aryl)dicyclohexylphosphonium tetrafluoroborate ligand in the conjugated synthesis of heteroaryl biphenyls

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00698A, Paper

Yue Hu, Wenjing Fu, Mengyu Zhou, Haoyue Xing, Sixuan Meng, Jian Chen, Qiong Chen, Rui Guo, Guang-Ao Yu
The development of novel indenyl ligands for carbon–carbon coupling reactions is a longstanding challenge, especially those used to obtain more efficient products, reduce the catalytic dosage, and provide greener reaction...
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HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00743K, Communication

Xiaochen Ji, Huawen Huang, Yixi Zhang
Cross-dehydrogenative coupling (CDC) reactions offer high atom economy and simple synthetic routes, and are widely employed for the coupling of heterocyclic rings. Herein, we report a transition-metal-free HBr-catalyzed aerobic CDC...
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A Hydrido-Alkynyl-Prins Cyclization Using Isopropanol as Hydride Donor: Discovery, Scope and Mechanistic Study

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00688D, Paper

Beeraiah Baire, Ramesh Gollachinnamola, Surabhi Mishra
The Alkynyl-Prins cyclization is a very important strategy in organic synthesis for the construction of cyclic frameworks and natural products, via vinyl carbocation intermediate under acid catalysis. Surprisingly, the alternate...
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Direct C4-H Amination of Pyridines and Quinolines under Benign Conditions

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00669H, Paper

Tong Han, Fenlian Xu, Xinqiao Nie, Dong Wang
Existing methods for the para-C-H amination of pyridines and quinolines are scarce and rely exclusively on indirect approaches. These typically involve initial installation of an amine surrogate or an aryl...
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Temperature-Directed in situ Generation of Fluorobenzyl Radicals: Utilization for the Complete Fluorobenzylation of Tri-, and Tetramethylbenzenes

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D5OB01908G, Paper

Dharmveer Bhedi, Ramalingam Thirumoorthi
Organofluorine compounds have been broadly employed in the fields of pharmaceuticals, agrochemicals, and materials. Concurrently, the well-known star-shaped molecules, 1,3,5-trifunctionalized-2,4,6-trialkylbenzene, are of interest in supramolecular chemistry. For the first time,...
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NMM-promoted decarboxylative C(sp3)–C(sp3) coupling of coumarin-3-carboxylic acids and indolin-3-ones

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00593D, Communication

Zhan-Yong Wang, Can Zhang, Xiao-Tian Wang, Xiao-Jin Sun, Yi-Lin Wang, Ting Yang, Chenyang Ma, Ran Xia, Hongxin Liu
A mild, metal-free cascade via Michael addition/decarboxylation affords biologically relevant indolin-3-one-substituted chroman-2-ones with excellent diastereoselectivity, broad scope, and operational simplicity at room temperature.
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Anti-adipogenic cyathane diterpenoids from Onychium japonicum

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00575F, Paper

Zhen-Yu Yang, Wen-Na Fan, Xiu-Qing Song, Yao-Yue Fan
Onychium japonicum, a Zhuang ethnic medicine, has demonstrated promising anti-obesity potential in preliminary pharmacological studies.
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Facile access to thioethers using sodium thiosulfate as the sulfur surrogate under base-mediated conditions

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00749J, Paper

Chu-Yun Wu, Cheng-Syun Yang, Tzu-Ying Sung, Ta-Cheng Chen, Po-Chiao Lin, Chien-Fu Liang
Bunte salts were used as sulfur transfer reagents to produce both symmetric and unsymmetric thioethers.
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Visible-light-driven metal-free iminyl radical cyanation for the synthesis of 3-cyanoindoles

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00711B, Paper

Nikita Gupta, Imtiaz Ahmed, Plaban Jyoti Sarma, Shilpa Neog, Gaurisankar Phukan, Vijay Kumar Das
A visible-light-driven method is presented for converting oximes into cyanoindoles through a mild green radical process. It offers a practical, sustainable approach to construct 3-cynao heterocycles, supported by detailed mechanistic and DFT studies.
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Nicotinic acid-catalyzed synthesis of novel benzothiazoles and benzimidazoles from carbohydrate-derived furfurals: structural, computational, and antimicrobial studies

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00468G, Paper

Prajwal Naik C, Saikat Dutta, Chethan B. S., Chethan Prathap K. N., Lokanath N. K., B. C. Revanasiddappa, Nitha Naveen Dsouza
The work reports the high-yielding synthesis of novel benzothiazoles and benzimidazoles from carbohydrate-derived furfurals using nicotinic acid as an innocuous organocatalyst. The products showed promising antibacterial and antifungal activities.
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Construction of an aptamer-conjuncted molecular artificial enzyme with enhanced activity and selectivity

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00401F, Paper

Yanjing Ke, Xindi Li, Wenhui Shi, Yuze Han, Xin Peng, Mengfan Wang
Although molecular artificial enzymes have displayed tremendous potential in many homogeneous reactions, their low catalytic selectivity is still a challenge. In this study, an aptamer strategy was developed to construct...
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Triphosgene-free solid-phase synthesis of urea-containing PSMA-targeting peptides for radiotheranostics: a comparative study

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00802J, Paper

Gemma E. Douglas, Madhusudan Vyas, Iman Kavianinia
Prostate-specific membrane antigen (PSMA) is a validated target for prostate cancer imaging and radiotherapy, with most high-affinity ligands incorporating the lysine–urea–glutamate (KuE) pharmacophore.
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Mechanochemical tuning of Pd(BIAN-NHC) allyl/cinnamyl complexes for enhanced cross-coupling

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00533K, Paper

Warda Parveen, Farhat Shakeel, Shehzad Muhammad Raffi, Xiangqun Chi, Bo Wang
Air-stable Pd(BIAN-NHC)-cinnamyl/allyl catalysts enable efficient, Suzuki and Buchwald–Hartwig couplings via mechanochemistry with low catalyst loading and highest yield.
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Synthesis, characterization, and impact of a carbon spacer on the geometry and antibacterial activity of a new series of 1,n-bis(5-cycloalkylsulfenyl-1,3,4-thiadiazole-2-sulfenyl) alkanes (n = 4 and 6)

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00750C, Paper

Syarifah Iliya Nor Za'im, Mamduhah Mohamad, Hayedeh Gorjian, Mohd Rafie Johan, Nader Ghaffari Khaligh
Study of the geometry and antibacterial activity of a new series of 1,n-bis(5-cycloalkylsulfenyl-1,3,4-thiadiazole-2-sulfenyl) alkanes.
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One-pot multicomponent synthesis of indole-linked fully substituted fused pyrroles

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00395H, Paper

Swadhin Swaraj Acharya, Rudranarayan Sutar, Girija Prasad Mishra, Bibhuti Bhusan Parida
Indoles and pyrroles are valued owing to their natural and pharmaceutical abundance and impressive biological profile. In this work a facile route for the synthesis of indole-linked fused pyrroles has been demonstrated.
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Recent advances in allylic and vinylic C–H bond functionalization of simple alkenes via visible-light photocatalysis

Org. Biomol. Chem., 2026, 24,4386-4406
DOI: 10.1039/D6OB00343E, Review Article

Open Access

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Etikala Ashok, Junghwa Woo, Juyoung Yang, Jungwon Kim
This review highlights recent advances in the allylic and vinylic C–H bond functionalization of simple alkenes via visible-light photocatalysis, based on diverse mechanistic pathways.
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Azirine-enabled regioselective synthesis of N-alkyl pyrazoles and indole–pyrazole conjugates via Cu-catalysed N–N bond formation

Org. Biomol. Chem., 2026, 24,4477-4487
DOI: 10.1039/D6OB00123H, Paper

Anjali Chaturvedi, Vishal Sharma, Pankaj Sharma, Manpreet Singh, Chandi C. Malakar, Ravindra Rawal, Virender Singh
An efficient and sustainable strategy for the regioselective synthesis of a new class of aliphatic N-substituted pyrazoles has been developed, using azirine-2H-carbaldehydes as versatile building blocks.
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One-step synthesis of Zolpidem and its analogues via visible light induced coupling of imidazo[1,2-α]pyridines with 2-bromoacetamides

Org. Biomol. Chem., 2026, 24,4529-4535
DOI: 10.1039/D6OB00267F, Paper

Shiyu Zhang, Min Li, Yuanjiu Xiao, Yangjianyun Zhang, Peng Deng, Tao Wu, Chun Xia, Wei Deng, Ze Tan
A highly simple and efficient method for synthesizing the drug Zolpidem and its analogues via the coupling of 2-phenylimidazo[1,2-α]pyridines with 2-bromoacetamides under blue LED irradiation has been developed.
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DFT investigation of the 2-aminothiazole-catalyzed five-component reaction of CO2/amines/aldehydes: multi-species synergistic activation and chemoselective control in N-methylation

Org. Biomol. Chem., 2026, 24,4495-4507
DOI: 10.1039/D6OB00185H, Paper

Xue Zhang, Qin Yu, Ying Zhou, Hua Zhi, Weiwei Gu, Li Li, Jiyang Zhao
The 2-aminothiazole catalyst acts as a synergistic hub coordinating reactive species, modulating reactivity and building a chemoselective methylation network.
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Diverse structural roles of ferrocene in mediating ferroptosis induction by ML162

Org. Biomol. Chem., 2026, 24,4437-4448
DOI: 10.1039/D6OB00389C, Paper

Jing Wang, Wei Li, Zeqi Zhu, Ruicheng Lv, Xuejing Fan, Xiaomin Zhang, Yong Wang
Diversified ferrocene-appended ML162 derivatives as potent ferroptosis inducers.
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Synthesis of spirooxindoles by the catalytic tandem reaction of 2-arylidene-1,3-indanediones with 2-(2-oxoindolin-3-yl)malononitriles

Org. Biomol. Chem., 2026, 24,4523-4528
DOI: 10.1039/D6OB00433D, Paper

Peng-Xin Guo, Da-Ming Du
A facile synthesis of spirooxindoles bearing a 3-oxoisobenzofuran-1(3H)-ylidene motif was developed via a tandem Michael addition/cyclization reaction between 2-arylidene-1,3-indanediones and 2-(2-oxoindolin-3-yl)malononitriles catalyzed by K₂CO₃.
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Electrocyclization of arylvinyl β-hydroxyacetonitrile to substituted cyanomethyl indene derivatives

Org. Biomol. Chem., 2026, 24,4508-4513
DOI: 10.1039/D6OB00526H, Paper

Amit Kumar, Jagadeesh Babu Nanubolu, Gangarajula Sudhakar
An easy method for accessing indene carboxylic acid and its derivatives has been developed from arylvinyl β-hydroxyacetonitriles in the presence of Lewis acids.
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Palladium-catalysed regioselective [4 + 2] annulation to access silatetralin-1-amines

Org. Biomol. Chem., 2026, 24,4417-4421
DOI: 10.1039/D6OB00525J, Communication

Yan Sun, Ruiqiang Lu, Hang Zhou, Liuzhou Gao, Yidong Wang
A palladium-catalysed [4 + 2] annulation is presented that renders previously inaccessible three-dimensional silatetralin-1-amines readily accessible from benzosilacyclobutenes and N-allenamides.
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Construction of P-stereogenic phosphine oxides via Lewis base-catalyzed enantioselective O-Boc protection

Org. Biomol. Chem., 2026, 24,4407-4411
DOI: 10.1039/D6OB00546B, Communication

Yike Wang, Xingkuan Chen, Jianfeng Xu
A Lewis base-catalyzed enantioselective O-Boc protection strategy for the construction of P-stereogenic phosphorus compounds has been developed.
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π-Spacer effects in 2,6-disubstituted BODIPY fluorophores for mitochondrial imaging

Org. Biomol. Chem., 2026, 24,4514-4522
DOI: 10.1039/D6OB00119J, Paper

Charutha Kalarikkal, Poonam Rani, Chinna Ayya Swamy P
Impact of π-spacer modulations coupled with organelle-specific targeting motifs on the optical properties as well as bioimaging applicability of BODIPY-based fluorophores.
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t BuONa/DMSO-mediated C–O bond cleavage of phenethyl ether derivatives

Org. Biomol. Chem., 2026, 24,4412-4416
DOI: 10.1039/D6OB00427J, Communication

Zhangqiang Yan, Zhen Zhang, Fei Wang, Lihua Ye, Shusheng Yue, Xiaoqing Lei, Jialu Su, Zhong-Ning Chen, Hu Cai
A transition-metal-free, radical-induced C–O cleavage of phenethyl ethers has been developed with a simple ^tBuONa/DMSO system under mild, non-photochemical, and non-electrochemical conditions.
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Stereoselective synthesis of 1′-α-cyano carbocyclic pyrimidine nucleoside analogs via a chelation-controlled 1′-α-hydroxymethylation strategy

Org. Biomol. Chem., 2026, 24,4456-4462
DOI: 10.1039/D6OB00377J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nicolas. G. Biteau, Mahesh Kasthuri, Dharmeshkumar Patel, Ramyani De, Raymond. F. Schinazi, Franck Amblard
Highly diastereoselective chelation-controlled 1′-α-hydroxymethylation strategy for the synthesis of 1′-α-cyano carbocyclic pyrimidine nucleoside analogs.
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Furan-2-carboxamides as dienes in a cascade SN2′/intramolecular Diels–Alder reaction with MBH carbonates

Org. Biomol. Chem., 2026, 24,4449-4455
DOI: 10.1039/D6OB00582A, Paper

Yang Zhang, Yuhan Li, Zhonglin Wei, Zhuoqi Zhang, Jinbao Xiang, Lianyou Zheng
Electron-deficient furan-2-carboxamides serve as competent dienes in a cascade S_N2′/intramolecular Diels–Alder reaction, enabling efficient and highly diastereoselective construction of polycyclic lactams.
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Intramolecular difunctionalization of alkynes involving cascade radical 1,4-heteroaryl migrations and formal total synthesis of a β-imidazolyl-γ-lactam alkaloid: isoanantine

Org. Biomol. Chem., 2026, 24,4488-4494
DOI: 10.1039/D6OB00554C, Paper

Yu-Tong Huang, Che-Chien Chang
Intramolecular difunctionalization of alkynes involving cascade radical 1,4-heteroaryl migrations was developed to complete the formal total synthesis of a β-imidazolyl-γ-lactam alkaloid: isoanantine.
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Energy transfer (EnT)-mediated [2 + 2] photocycloadditions

Org. Biomol. Chem., 2026, 24,4361-4385
DOI: 10.1039/D6OB00557H, Review Article

Suven Das, Arpita Dutta
This review highlights recent (2022–2025) advances in energy-transfer (EnT)-enabled inter-/intramolecular [2 + 2] photocycloadditions as well as [2π + 2σ] cycloadditions for the construction of substituted and fused cyclobutane frameworks.
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Radical bromination/cascade cyclization: a facile approach towards benzimidazole-fused isoquinolinones

Org. Biomol. Chem., 2026, 24,4422-4425
DOI: 10.1039/D6OB00380J, Communication

Hong Zhang, Qi Yue, Zhenyu Yao, Zi Yang, Xiuling Cui
A radical cyclization of 2-arylbenzimidazoles and TBAB mediated by K₂S₂O₈ is developed, providing a new avenue for bromine incorporation.
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Utility of α-halodicyclopentadienones for the synthesis of novel fused heterocycles

Org. Biomol. Chem., 2026, 24,4463-4476
DOI: 10.1039/D6OB00317F, Paper

Sohan Lal, Gangavara L. Tejashree, Dipankar Das, Bishwajit Ganguly, Arindrajit Chowdhury, Irishi N. N. Namboothiri
A Michael addition–cyclization strategy involving α-halodicyclopentadienones with amidines, oxindoles and thio-oxindoles for the construction of fused imidazoles, spirocyclopropyl oxindoles and thienoindoles has been developed.
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Photocaging the C6-carboxylate of β-glucuronide prodrugs enables spatiotemporally controlled release of anticancer agents via a dual activation strategy

Org. Biomol. Chem., 2026, 24,4426-4436
DOI: 10.1039/D6OB00139D, Paper

Junjie Fu, Dianya Yong, Jie Liu, Yunying Tan, Hongyu Yang, Jing Hu, Jian Yin
Carboxylate caging overcomes uptake limitations and permits spatiotemporally controlled activation of β-glucuronide prodrugs in cancer cells.
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2-Substituted oxazolyl and thiazolyl amino acids are suitable P1 surrogates for new SARS-CoV-2 main protease inhibitors

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00697C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Zijie Liu, Tayla J. Van Oers, Conrad Fischer, Anna Nguyen, Johnson Chew, John C. Vederas
Synthesis of enantiopure heteroazole amino acid building blocks from commercially available materials for incorporation into SARS-CoV-2 M^pro inhibitors as alternatives to the cyclic glutamine P1.
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Oxidative trifunctionalization of indoles with 2-aminobenzyl alcohols: access to iodo-indoloquinoline scaffolds

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00682E, Paper

Yaping Zhu, Xinyan Yu, Qinghua Chen, Yong Wang, Liang Zhang, He Zhao, Changjian Zhou, Yong Dai
A facile metal-free synthetic strategy towards indoloquinoline scaffolds via green oxidative functionalization of 2-aminobenzyl alcohols.
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Copper-catalyzed trifluoromethylation of vinyl azides with BrCF2CO2K: synthesis of α-trifluoromethyl ketones without external fluoride sources

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00710D, Communication

Qinhong Wen, Tianhao Zhang, Xinyu Jia, Yu Wang, Yue Zhao, Taichen Liu, Kai Wei, Zhenghui Kang, Jiuling Li
Cu(I)-catalysed trifluoromethylation of vinyl azides with BrCF₂CO₂K/H₂O produces α-trifluoromethyl ketones without external fluoride. Copper–difluorocarbene pathway enables broad scope, advancing metal difluorocarbene synthetic chemistry.
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Copper-catalyzed synthesis of monosubstituted carbodiimides from aromatic amines

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00538A, Communication

Yash Dhaduk, Maulik Pethani, Arti Ramani, Hassan Abdul Basheer K V, Hussain Bhukya, Togati Naveen
An efficient copper-catalysed strategy for mild and selective synthesis of carbodiimides from aromatic amines.
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Photocatalytic radical addition/bicyclization of 1,7-enynes with N-sulfonylaminopyridinium salts/sulfamoyl chlorides: access to sulfonamide-containing benzo[a]fluoren-5-ones

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00641H, Paper

Zhichao Chen, Zhiyong Jiang, Fengjiao Lv, Xiaolan Xie
A visible light-induced bicyclization of 1,7-enynes with N-sulfonylaminopyridinium salts/sulfamoyl chlorides has been developed. This protocol features mild conditions with a broad substrate scope.
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Palladium-catalyzed migratory allylic sulfonylation of allylic alcohols using sulfonyl hydrazides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00512H, Paper

Xianzhi Yang, Dan Zhao, Yu Liu, Can Zhu
Palladium-catalyzed migratory allylic sulfonylation of allylic alcohols with sulfonyl hydrazides has been established with good chemo- and regioselectivity.
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Copper-Catalyzed Synthesis of Xanthine–Chalcogenide Hybrids: Structural Diversity, DNA-Interaction Studies, and Docking Simulation

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00464D, Paper

Clara Holthausen, Isabella Barbosa dos Reis Carlos, Suzane Quintana, Isis J. A. Granja, Suelen Santos Da Silva, Angelica Ceci da Silva, Eduardo Junca, Matheus V.G. Zimmermann, Ismael Raitz, Leonardo B Federico, Antonio Luiz Braga, Jamal Rafique, Sumbal Saba, Tiago Frizon
Copper-catalyzed C(sp²)-H chalcogenylation was employed for the efficient synthesis of a series of xanthine-chalcogenide hybrids using diaryl dichalcogenides as chalcogen sources. The reactions proceeded under mild conditions, providing the desired...
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Steric bulk & solubility provide synthetic access & insight into non-symmetric perylenediimide syntheses

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00321D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Brittany R. Pollok, Aubrey R. Caplin, Meghan T. Blakeslee, Sean T. Roberts, Michael J. Rose
Non-symmetric PDIs achieved via sequential imidization: Tailoring first and second imidization conditions through amine selection and solubility enables synthesis of versatile, high-utility molecular derivatives for further synthetic application.
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Hypervalent iodine-mediated cyclization of N-vinyl amides for the synthesis of 4-functionalized dihydrooxazolines

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00685J, Paper

Jiwoo Lee, Suhui Kim, Chang Sung Hong, Bomcha Park, Yeong-Joon Kim, Sungwook Choi, Ki Bum Hong
A hypervalent iodine-mediated heterofunctionalization of N-vinyl amides has been developed using PhI(OAc)₂/KI under mild conditions.
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Synthesis of masked α,β-unsaturated trifluoromethyl ketones via iodine(III)-mediated double decarboxylative trifluoroacetylation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00763E, Communication

Nan Xia, Ming-Chao Li, Jie Zhou, Jun Xu, Hua-Jian Xu
An iodine(III)-mediated double decarboxylative trifluoroacetylation of α,β-unsaturated carboxylic acids with cyclic CF₃-pyruvate acetals under simple thermal conditions is reported.
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Guanidine-based azines from N-heterocyclic carbene (NHC)-derived selenoureas and diazo compounds: synthesis, structural diversification, and biological evaluation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00548A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dimitrios K. Giannopoulos, Ilias Papantzimas, Spyridon A. Ferikoglou, Efstathios Tonis, Nikolaos V. Tzouras, Athanasios Pseftogas, Fady Nahra, Steven P. Nolan, Aristides G. Eliopoulos, Georgios C. Vougioukalakis
We report a synthetic strategy to guanidine-based azines from NHC-derived selenoureas and functionalized diazo compounds, with broad scope and chromatography-free workup via recyclable PS-PPh₃, showing promising anti-cancer potential.
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Photoenzymatic new-to-nature transformations via electron donor–acceptor complexes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00560H, Review Article

Lei Zhang, Fan Zhou, Jing Wang, Jialuo Zou
This review summarizes recent progress in the development of EDA complex-mediated abiological transformations in photoenzymatic reactions, highlighting their capacity to enable the asymmetric construction of diverse molecular skeletons.
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Azine-fused [6]carbohelicenes: synthesis, crystal structure, stereoisomerism and optical properties

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00620E, Paper

Sergey S. Marchenko, Samita J. Sokha, Oleg P. Demidov, Anatoly V. Chernyshev, Anatoly V. Metelitsa, Sergei S. Brig, Ilya V. Prolomov, Michael G. Medvedev, Anna V. Gulevskaya
Novel azine-fused [6]helicenes were prepared. The X-ray structures, UV-vis absorption and fluorescence spectra of the helicenes were investigated and compared to those of the parent [6]carbohelicene.
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Synthesis of mesoionic carbene-triazole-based Pd(II) complex: promoting C–H activation toward N-aryl carbazoles

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00378H, Paper

Puneet Singh Gahlaut, Bhawana Shekhawat, Prem Lama, Barun Jana
This work presents the synthesis of a novel Pd–MIC complex that enables diverse N-aryl carbazoles. Furthermore, nitration and chalcogenation have been introduced as extensions toward potential post-functionalization pathways.
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Total Synthesis of (+)-Cassiol

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00545D, Paper

Badrodin Ayyub Shaikh, Shoba R Tejesvani
Total synthesis of cassiol was accomplished from geraniol in nine steps. Yamamoto epoxide rearrangement was used to establish the chiral quaternary center, while ring closing metathesis was used to construct...
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Photochemical Reductive Coupling of α-Keto esters for Synthesizing 2,3-Diarylated Tartaric Acid Esters

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00535G, Communication

Yong Qin He, Yuzhen Ye, Qiwei Yao, Guogang Tu, Tiansheng Zhao, Hao Qiu, Jia Song, Wan-Fa Tian, Chunbo Zhang
A metal- and photocatalyst-free method for reductive homocoupling of α-ketoesters using ascorbic acid as a mild hydrogen source is reported. This approach avoids strong stoichiometric reductants or complex photocatalysts, The...
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Propargyl uridine-based synthesis of glycosylated RNA analogues

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00597G, Paper

Jia-Yan Wei, Bo-Xu Gai, Chuan-Shuo Wu, Li Liu, Liang Cheng
We establish a modular click-chemistry platform enabling site-selective synthesis of structurally defined glycosylated RNA mimics at nucleoside and oligonucleotide levels.
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Metal-free N-arylation of sulfoximines using diaryliodonium salts at room temperature

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00638H, Communication

Rajesh K. Marag, Deeksha, Ritesh Singh
A transition-metal-free method for the N-arylation of NH-sulfoximines at room temperature has been developed, offering broad functional-group tolerance and high efficiency.
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Imine-directed Ru(II)-catalyzed ortho-C(sp2)–H amidation of 3-arylquinoxalin-2(1H)-ones via nitrene transfer from acyl/heteroacyl azides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00532B, Paper

Shivani Sapra, Sunil K. Singh, Brajendra K. Singh
Imine-directed Ru(II)-catalyzed regioselective ortho-C(sp²)–H amidation of 3-arylquinoxalin-2(1H)-ones with acyl and heteroacyl azides furnished 36 novel amides with broad substrate scope, late-stage functionalization, and gram-scale applicability.
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Photo-driven synthesis of N-sulfonylformamidines: a catalyst- and sensitiser-free approach

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00595K, Paper

Moitreyee Bhattacharjee, Prodeep Phukan
A sustainable photochemical nitrene-mediated strategy for the sulfonylimination of formamides via white LED-enabled activation of N,N-dibromoarylsulfonamides, yielding a library of N-sulfonylformamidines under mild and operationally simple conditions.
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Correction: Assessment of solvent exposure of native cysteines in human Hsp90 using thiol-reactive functional tags

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB90064J, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ya-Xin Xie, Xi-Wei Wang, Xing Zhang, Jia-Long Zhao, Dan Cheng, Yin Yang, Daniela Goldfarb, Xun-Cheng Su
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Rapidly photocleavable triazene-functionalized nucleotides for DNA sequencing

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00577B, Paper

Pingyang Wang, Yumei Shen
A method for the preparation of triazene-functionalized nucleotides and their fast photocleavable application in DNA sequencing are described.
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Substituent effects on photoresponsive nitric oxide release by N-nitrosoaniline derivatives

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00679E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Haruka Tsuchiya, Osuke Yoshikawa, Mei Harada, Mikako Ogawa, Yuhei Ohta, Hidehiko Nakagawa, Naoya Ieda
The structure–activity relationship of photocontrollable NO releasers was investigated. It was suggested that the differences in photoreactivity originate from differences in the propensity for transition to the charge transfer (CT) excited state.
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Terpenoid-derived β-ketoesters: acid-induced rearrangements in the homocamphor series

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00619A, Paper

Tkachenko Ilya Mikhailovich, Nezamutdinova Kamila Renatovna, Olga A. Lodochnikova, Klimochkin Yuri Nikolaevich
This work describes acid-catalyzed cascade transformations of homocamphor-derived β-ketoesters into [2.2.2]-skeleton fused and embedded lactones.
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Halogen-mediated C2/C3 functionalization of indoles: a concise overview

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00635C, Review Article

Mariyaraj Arockiaraj, Rojalini Nayak, Venkatachalam Rajeshkumar
This review highlights halogen-mediated C2/C3 functionalization of indoles using molecular halogens and N-halosuccinimides for diverse bond-forming transformations, offering an efficient platform for sustainable indole functionalization.
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Cationic imidazolium macrocycles enable array-based, site-selective optical detection of peptide phosphorylation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00562D, Paper

Arman C. Garcia, Ria Lian, Parisa Fasihianifard, Lin He, Ryan R. Julian, Veronica Carta, Chia-en A. Chang, Richard J. Hooley
Polycationic imidazolium macrocycles show strong affinity for anionic and hydrophobic peptides, and can be paired with dyes in an arrayed format to enable site- and state-selective optical detection of serine phosphorylation.
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Ketoreductase domain mutagenesis reprogrammes chain-length control in alternapyrone biosynthesis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00604C, Communication

Inthira Tapeng, Jaiyfungkhong Phakeovilay, Pakorn Wattana-Amorn
Ketoreductase domain mutation in MtAltA produced compounds 1 and 2 instead of alternapyrone, indicating its role in chain-length programming.
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Dual-gated photochromism for both directions of azobenzene isomerization via metal complexation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00702C, Paper

Koji Yamakawa, Masaki Yamamura, Tatsuya Nabeshima
A macrocyclic ligand bearing two azobenzene and terpyridine units forms metal complexes. The trans complex suppresses photoisomerization, whereas the cis complex is completely inert, demonstrating dual-gated photochromism of both azobenzene isomers.
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Bovine serum albumin: an effective and eco-friendly biocatalyst for one-pot, three-component synthesis of valuable imidazole N-oxides in H2O–EtOH medium

Org. Biomol. Chem., 2026, 24,4325-4333
DOI: 10.1039/D5OB01970B, Paper

Koustav Singha, Imran Habib, Pintu Pratihar, Dilip Kumar Maiti, Mossaraf Hossain
A one-pot, three-component reaction procedure for the synthesis of valuable bioactive imidazole N-oxide derivatives, using the biocatalyst BSA with the application of an incubator shaker in a water–ethanol (4:6) solvent mixture, has been developed.
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One-pot click chemistry using hydrazine as an azide surrogate: easy access to 1,2,3-triazole functionalities

Org. Biomol. Chem., 2026, 24,4298-4304
DOI: 10.1039/D6OB00521G, Paper

Muzamil Samad, Mohd Irfan, Riyaz Ahmed, Zaheen Akhter, Vijay Kumar, Parvinder Pal Singh
A green, one-pot CuAAC using phenylhydrazine HCl as azide surrogate in PEG-400/H₂O enables safe, chromatography-free synthesis of 1,2,3-triazoles in high yields with broad scope and late-stage functionalization.
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Base-promoted synthesis of α,β-unsaturated amides via C–N bond formation using α,β-unsaturated acids and isothiocyanates

Org. Biomol. Chem., 2026, 24,4320-4324
DOI: 10.1039/D6OB00514D, Paper

Aditya Rai, Krishna Nand Singh
An efficient metal-free strategy is reported for the synthesis of α,β-unsaturated amides from α,β-unsaturated carboxylic acids with isothiocyanates.
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Scalable mechanochemical synthesis of a cyclic dehydroalanine peptide

Org. Biomol. Chem., 2026, 24,4242-4247
DOI: 10.1039/D6OB00662K, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jamie C. Thuan, Katelyn M. Barron, Jun Ohata
This work identified liquid-assisted mechanochemistry as a more reliable way to synthesize the dehydroalanine-based diketopiperazine derivative.
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Pd(II)-catalyzed oxidative cyclization of amino alcohols with 1,3-cyclohexadiene: a route to fused morpholine derivatives

Org. Biomol. Chem., 2026, 24,4237-4241
DOI: 10.1039/D6OB00613B, Communication

Mao Ye, Xiaoya Zhuo, Xiangwen Tan, Wanqing Wu, Huanfeng Jiang
A Pd(II)-catalyzed aerobic oxidative cyclization of amino alcohols with 1,3-cyclohexadiene has been developed. This protocol enables efficient synthesis of diverse morpholines from cyclic or acyclic dienes under mild conditions.
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Synthesis of azido-modified enamides via CC isomerisation of functionalised Ugi adducts

Org. Biomol. Chem., 2026, 24,4264-4272
DOI: 10.1039/D6OB00513F, Paper

Vladyslav Vereshchak, Sofia Fadieieva, Yevhen Kasianenko, Viacheslav Saraiev, Olena Shvets, Vladimir Musatov, Svitlana Shishkina, Valentyn Chebanov, Alexander Tsygankov
Combining the Ugi-4CR of α,β-unsaturated aldehydes with late-stage azidation as an efficient and selective access to diverse functionalized dehydropeptidomimetics.
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An adenine-based molecular rotor as a fluorescent nucleobase with high brightness

Org. Biomol. Chem., 2026, 24,4334-4341
DOI: 10.1039/D6OB00486E, Paper

Anna A. Pushkarevskaya, Polina N. Kamzeeva, Evgeny S. Belyaev, Vladimir A. Brylev, Alexander A. Lomzov, Andrey V. Aralov
An approach to increasing fluorescence brightness of nucleobases has been developed, and its applicability was demonstrated by a bright adenine-based molecular rotor oxo-Ade^BZT with uniform hybridizing properties.
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Metal-free, iodine/DMSO-promoted oxidative C(sp2)–H difunctionalization: synthesis of aminochalcogenylated indoles

Org. Biomol. Chem., 2026, 24,4342-4350
DOI: 10.1039/D6OB00362A, Paper

Satyajit Pal, Subhankar Sarkar, Tanmay Pramanik, Anindita Mukherjee, Sougata Santra, Grigory V. Zyryanov, Adinath Majee
A metal-free iodine/DMSO protocol enables oxidative difunctionalization of indoles via C(sp²)–H coupling between amines and diphenyl dichalcogenides under mild conditions, affording C(sp²)–N and C(sp²)–S/Se bonds in good yields.
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Total synthesis of γ-tocopherol via asymmetric 1,4-conjugate addition of alkyl Grignard reagents to 2-methyl chromone

Org. Biomol. Chem., 2026, 24,4248-4252
DOI: 10.1039/D6OB00616G, Communication

Ya-Ling Li, Yue Liu, Dong-Mei Yao, Jing-Dong Zhang, You-Cai Xiao, Fen-Er Chen
Cu^I/(S,R)-rev-Josiphos-catalyzed asymmetric 1,4-addition of alkyl Grignard reagents to 2-methyl chromones enabled access to chiral tetrasubstituted chromanones with broad scope, excellent regioselectivity, and up to 97% ee.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium catalyzed cross-couplings of trans-vinylboranes with alkyl bromides: a reversed-polarity alternative to B-alkyl Suzuki reactions

Org. Biomol. Chem., 2026, 24,4273-4280
DOI: 10.1039/D6OB00314A, Paper

Petros Danielsen Siapkaras, Kristian Sørnes, Jens Mortansson Jelstrup Nolsøe, Filip Ekholm, Eirik Johansson Solum, Marius Aursnes
A variety of trans-alkenyl-9-BBN derivatives have been prepared in situ and then coupled with alkyl bromides by utilizing palladium catalysis with the electron-rich and sterically encumbered tricyclohexylphosphine ligand.
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Metal-coordination-driven self-assembly of 8-hydroxyquinoline–peptide into hybrid nanomaterials for in vitro multimodal synergistic anticancer activity

Org. Biomol. Chem., 2026, 24,4287-4297
DOI: 10.1039/D6OB00498A, Paper

Shengyao Wang, Xin Tian, Xinming Li
Self-assembling hybrid nanomaterials with synergistic chemodynamic, photothermal, and chemotherapy properties were prepared from copper-coordinated conjugates of 8-hydroxyquinoline and a peptide segment.
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Visible light-driven strategies for the synthesis of pyrazole scaffolds: needs, mechanistic insights and sustainable horizons

Org. Biomol. Chem., 2026, 24,4138-4178
DOI: 10.1039/D5OB01676B, Review Article

Nisha, Aman Kumar, Vinod Kumar
Pyrazoles have numerous applications in pharmaceuticals, agrochemicals, and functional materials. This article highlights the developments of visible-light-driven, greener, and sustainable synthetic protocols for pyrazoles.
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NF3 for difluoroamination of tertiary lithium reagents

Org. Biomol. Chem., 2026, 24,4232-4236
DOI: 10.1039/D6OB00301J, Communication

Hong Xu, Jin-Hong Lin, Ji-Chang Xiao
We report a difluoroamination reaction using nitrogen trifluoride (NF₃) as the –NF₂ source, initiated via single-electron reduction by organolithium reagents.
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An imine condensation/1,5-electrocyclization cascade enabled permanent aldehyde–amine coupling through a triazole linkage

Org. Biomol. Chem., 2026, 24,4312-4319
DOI: 10.1039/D6OB00410E, Paper

Yi Li, Cheng-Cheng Wei, Xiao-Jing Tian, Peng Jin, Guo-Juan Song, Licheng Xie, Gong Chen, Mei-Hua Shen, Hua-Dong Xu
Reversible imine condensation is captured by a 1,5-electrocyclization opening and closing cascade to form a robust triazole linkage efficiently and cleanly.
The content of this RSS Feed (c) The Royal Society of Chemistry