RSC - Org. Biomol. Chem. latest articles

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB27290G, Paper

P. Horrocks, M. R. Pickard, H. H. Parekh, S. P. Patel, Ravindra B. Pathak
A series of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives were synthesised. These compounds were tested for their in vitro antifungal and antitubercular activity. The title compounds showed potent antitubercular and antifungal activities.
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Successful combination of computationally inexpensive GIAO 13C NMR calculations and artificial neural network pattern recognition: a new strategy for simple and rapid detection of structural misassignments

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40843D, Paper

Ariel M. Sarotti
GIAO NMR chemical shift calculations coupled with trained artificial neural networks provides a new strategy for simple, rapid and reliable identification of structural misassignments of organic compounds.
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Formation of tetrahydrofurans via a 5-endo-tet cyclization of aziridines - synthesis of (-)-pachastrissamine

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40797G, Paper

Chen-Wei Lin, Hsin-Wei Liu, Duen-Ren Hou
The formation of tetrahydrofurans from 2-hydroxyalkyl-oxirane or aziridine is reported. The 5-endo-tet cyclization/ring opening of aziridine went smoothly to give tetrahydrofurans (THFs) under mild conditions. In contrast, the corresponding process...
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Photoswitchable DNA-binding properties of a photochromic spirooxazine derivative

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40930A, Paper

Jochen Mattay, Heiko Ihmels, Florian May, Laura Thomas
A N-methylphenanthrolinium-annelated spirooxazine derivative 2SO was prepared whose DNA-intercalating properties are reversibly changed by a photochromic reaction. Upon irradiation at 350 nm the spirooxazine is transformed to the corresponding photomerocyanine...
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MECHANISMS OF DNA DAMAGE BY PHOTOEXCITED 9-METHYL-[small beta]-CARBOLINES

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40344K, Paper

Franco Martin Cabrerizo, Bernd Epe, Rosa Erra-Balsells, Kathrin Butzbach, Federico Ariel Osvaldo Rasse-Suriani, Mariana Vignoni
It has been well documented that [small beta]-carboline alkaloids, particularly the 9-methyl derivatives, are efficient photosensitizers. However, structure-activity relations are missing and the photochemical mechanisms involved in the DNA photodamage still...
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Electrophilicity: the "Dark-Side" of Indole Chemistry

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40735G, Perspective

Marco Bandini
Indole is by far one of the most popular heterocyclic scaffolds in nature. The intriguing and challenging molecular architectures of polycyclic naturally occurring indolyl compounds constitute a continuous stimulus for...
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Transition metal free hydrolysis / cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB41069B, Communication

Ali Nakhi, Shafiqur Rahman Mohammad, Guru Pavan Kumar Seerapu, Rakesh Kumar Banote, Kummari Lalith Kumar, Pushkar Kulkarni, Devyani Haldar, Manojit Pal
A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines / pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single...
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A divergent approach to the synthesis of simplexides and congeners via a late-stage olefin cross-metathesis reaction

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40552D, Paper

Jiakun Li, Wei Li, Biao Yu
A series of immunosuppressor simplexides and congeners with variations on the lipid chains has been synthesized via a late-stage olefin cross-metathesis reaction.
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Tunable electronic interactions between anions and perylenediimide

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40703A, Paper

Flynt S. Goodson, Dillip K. Panda, Shuvasree Ray, Atanu Mitra, Samit Guha, Sourav Saha
In aprotic solvents, electron deficient perylenediimide (PDI-1) is reduced to PDI-1[radical dot]^- radical anions by strong Lewis basic hydroxide and fluoride anions, but remains silent to less basic chloride, bromide, iodide, and hexafluorophosphate ions.
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Synthetic evaluation of disulphide-bonded sarafotoxin on a poly(oxy ether) grafted dendrimeric poly(alkyl amine) support for polymer assisted organic synthesis

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40178B, Paper

M. A. Siyad, G. S. Vinod Kumar
This paper describes the synthesis, characterization and assessment of a novel class of insoluble polymeric polystyrene supports which combines polar poly(ethylene glycol)dimethacrylate as a cross-linker and poly(ethylene glycol) grafted poly(N,N-bisethylamine) as a dendritic template.
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Development of [small alpha]-glucosidase inhibitors by room temperature C-C cross couplings of quinazolinones

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40636A, Paper

Ramesh Garlapati, Narender Pottabathini, Venkateshwarlu Gurram, Kumara Swamy Kasani, Rambabu Gundla, Chiranjeevi Thulluri, Pavan Kumar Machiraju, Avinash B. Chaudhary, Uma Addepally, Raveendra Dayam, Venkata Rao Chunduri, Balaram Patro
Novel quinazolinone based [small alpha]-glucosidase inhibitors have been developed using a virtual screening model.
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A zinc-salophen/bile-acid conjugate receptor solubilized by CTABr micelles binds phosphate in water

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40724A, Communication

Ondrej Jurcek, Massimo Cametti, Marta Pontini, Erkki Kolehmainen, Kari Rissanen
Receptor 1, composed of two deoxycholic acid moieties appended to a Zn-salophen complex, was prepared, characterized and tested for anion binding by ¹H NMR and UV-vis spectroscopic techniques.
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Orthogonally protected D-galactosamine thioglycoside building blocks via highly regioselective, double serial and double parallel inversions of [small beta]-D-thiomannoside

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40935J, Paper

Madhu Emmadi, Suvarn S. Kulkarni
An efficient route for the synthesis of orthogonally protected D-galactosamine thioglycosides from D-mannose and its application to the synthesis of the rare disaccharide moiety of the zwitterionic polysaccharide of Bacteroides fragilis and Tn antigen is described.
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The origin of enantioselectivity in the L-threonine-derived phosphine-sulfonamide catalyzed aza-Morita-Baylis-Hillman reaction: effects of the intramolecular hydrogen bonding

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40144H, Paper

Richmond Lee, Fangrui Zhong, Bin Zheng, Yuezhong Meng, Yixin Lu, Kuo-Wei Huang
The intramolecular N-HO H-bond was identified to be crucial in inducing a high degree of stereochemical control in both the enolate addition to imine and the subsequent proton transfer step.
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Incorporation of a calixarene-based glucose functionalised bolaamphiphile into lipid bilayers for multivalent lectin recognition

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40732B, Paper

S. Aleandri, A. Casnati, L. Fantuzzi, G. Mancini, G. Rispoli, F. Sansone
The incorporation of a new glucosylated bolaamphiphile into DOPC liposomes rigidifies the lipophilic bilayer, thus reducing leakage from the internal aqueous phase, and allows a multivalent interaction with Concanavalin A.
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C-H[middle dot][middle dot][middle dot]O Non-Classical Hydrogen Bonding in the Stereomechanics of Organic Transformations: Theory and Recognition

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40828K, Perspective

Ryne C. Johnston, Paul Ha-Yeon Cheong
This manuscript describes the role of non-classical hydrogen bonds (NCHBs), specifically C-H[middle dot][middle dot][middle dot]O interactions, in modern synthetic organic transformations. Our goal is to point out the seminal examples where C-H[middle dot][middle dot][middle dot]O interactions...
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Tris(2-aminoethyl)amine based tripodal urea receptors for oxalate: encapsulation of staggered vs. planar conformers

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB41071D, Communication

Purnandhu Bose, Ranjan Dutta, Pradyut Ghosh
Simple tris(2-aminoethyl)amine (TREN) based tripodal urea receptors are investigated for the encapsulation of divalent oxalate (C₂O₄^2-) in a semi-aqueous medium.
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The Cascade Radical Cyclisation Approach to Prenylated Alkaloids: Synthesis of Stephacidin A and Notoamide B

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40979A, Paper

N S Simpkins, Louise Male, Ilias Pavlakos, Michael Weller
A strategy for the synthesis of members of the prenylated indole alkaloid family is described, which involves a radical cascade process of an appropriately substituted diketopiperazine (DKP) core structure. Several...
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Synthesis and reactivity of 5-polyfluoroalkyl-5-deazaalloxazines

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB26837C, Paper

Sergii Dudkin, Viktor Iaroshenko, Vyacheslav Sosnovskikh, Andrey A Tolmachev, Peter Langer
Reaction of 6-arylamino-1,3-dialkyluracils with anhydrides of polyfluorocarboxylic acids in the presence of pyridine and subsequent cyclization with concentrated H2SO4 gave the corresponding 1,3-dialkyl-5-(polyfluoroalkyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-diones (5-polyfluoroalkyl-5-deazaalloxazines). The reactivity of these compounds against...
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Humulane-type sesquiterpenoids from Pilea cavaleriei subsp. crenata

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40872H, Paper

Cang-Song Liao, Chun-Ping Tang, Sheng Yao, Yang Ye
This paper focused on the isolation and structural elucidation of nine new and uncommon humulane-type sesquiterpenoids from Pilea cavaleriei.
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Iridium-catalyzed asymmetric ring-opening of azabicyclic alkenes with alcohols

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40891D, Paper

Dingqiao Yang, Jiuyun Xia, Yuhua Long, Zhongyi Zeng, Xiongjun Zuo, Sanyong Wang, Chunrong Li
A novel asymmetric ring-opening reaction of N-substituted azabenzonorbornadienes with a wide variety of substituted benzyl alcohols and the addition reaction of N-substituted azabenzonorbornadienes with thiols are reported.
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Directed studies towards the total synthesis of (+)-13-deoxytedanolide: simple and convenient synthesis of the C8-C16 fragment

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40674A, Paper

Sebastien Meiries, Alexandra Bartoli, Melanie Decostanzi, Jean-Luc Parrain, Laurent Commeiras
A straightforward synthesis for enantioenriched C8-C16 south part of (+)-13-deoxytedanolide has been reported.
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Chemical synthesis of a masked analogue of the fish antifreeze potentiating protein (AFPP)

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB41066H, Paper

Margaret A Brimble, Sung Hyun Yang, Paul Harris, Joanna Wojnar, Clive Evans, Arthur L de Vries
A recently identified Antarctic fish protein termed antifreeze potentiating protein (AFPP) is thought to act as an adjunct to the previously characterised antifreeze glycoproteins (AFGPs), the two acting together to...
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Extending the range of supercritical fluid chromatography by use of Water-rich Modifiers

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB41121D, Communication

Erik Luis Regalado, Jinchu Liu, Ingrid Mergelsberg, Christopher J Welch
In this study we investigate the recently reported use of water-containing modifiers for separation and purification of hydrophilic compounds by supercritical fluid chromatography. Improved peak shape is obtained for a...
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Quick and reversible photocrosslinking reaction of 3-cyanovinylcarbazole nucleoside in a DNA triplex

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40915E, Communication

Kenzo Fujimoto, Hiroki Yoshinaga, Yasumasa Yoshio, Takashi Sakamoto
3-Cyanovinylcarbazole nucleoside (^CNVK), which can quickly photocrosslink to the pyrimidine base in the DNA double strand, was incorporated into a triplex forming oligonucleotides (TFO(s)) and the photoreactivity of the TFOs were evaluated.
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Stereoselective synthesis of original spirolactams displaying promising folded structures

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40643A, Paper

Guilhem Chaubet, Thibault Coursindel, Xavier Morelli, Stephane Betzi, Philippe Roche, Yannick Guari, Aurelien Lebrun, Loic Toupet, Yves Collette, Isabelle Parrot, Jean Martinez
The synthesis and characterization of unprecedented spirolactam scaffolds are reported, highlighting one particular helical structure that putatively resembles a PolyProline II helix.
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Various cyclization scaffolds by a truly Ugi 4-CR

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40523K, Paper

Mantosh K. Sinha, Kareem Khoury, Eberhardt Herdtweck, Alexander Domling
Utilizing a newly discovered Ugi variation, we present various methods to produce four diverse heterocyclic scaffolds.
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The effect of loop residues in four-stranded dimeric structures stabilized by minor groove tetrads

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40741A, Paper

Nuria Escaja, Irene Gomez-Pinto, Julia Viladoms, Enrique Pedroso, Carlos Gonzalez
Two-residue loops are optimal for the formation of four-stranded dimeric structures stabilized by minor groove tetrads.
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Direct C-H sulfenylation of purines and deazapurines

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40881G, Paper

Martin Klecka, Radek Pohl, Jan Cejka, Michal Hocek
A general method for Cu-catalyzed C-H sulfenylation of purines, 7-deaza- and 9-deazapurines with aryl- or alkyldisulfides has been developed. In purines, the reaction occurs at position 8, in 7-deazapurines at...
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Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes

Org. Biomol. Chem., 2013, 11,4333-4339
DOI: 10.1039/C3OB40438B, Paper

Martin Mattarella, Jaime Garcia-Hartjes, Tom Wennekes, Han Zuilhof, Jay S. Siegel
Corannulene derivatives, functionalized, via copper-catalyzed alkyne-azide cycloaddition (CuAAC) reactions, with galactose and the ganglioside GM1-oligosaccharide (GM1os), were evaluated for their ability to inhibit the binding of cholera toxin to its natural ligand; in this assay, GM1os-sym-corannulenes proved to be nanomolar inhibitors.
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Reaction of benzoxanthene lignans with peroxyl radicals in polar and non-polar media: cooperative behaviour of OH groups

Org. Biomol. Chem., 2013, 11,4291-4294
DOI: 10.1039/C3OB40723C, Communication

Carmela Spatafora, Carmelo Daquino, Corrado Tringali, Riccardo Amorati
Biomimetic oxidative coupling of caffeic acid esters affords new lignan antioxidants having highly reactive guaiacol-like and catechol-like OH groups.
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Development of ratiometric near-infrared fluorescent probes using analyte-specific cleavage of carbamate

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40932E, Communication

Dongjian Zhu, Guoping Li, Lin Xue, Hua Jiang
In terms of analyte-induced carbamate cleavage, two fluorescent probes, CyNB and CyNN₃, exhibit a significant analyte-triggered response with ratiometric fluorescence change in the NIR range and dual-emission ratiometry in living cells.
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Synthesis of 2,6-disubstituted pyridin-3-yl C-2[prime or minute]-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40774H, Paper

Tomas Kubelka, Lenka Slavetinska, Vaclav Eigner, Michal Hocek
Chemoselective cross-coupling reactions of bromo-chloropyridine C-nucleosides followed by another coupling or nucleophilic substitution were used for the synthesis of a library of 2,6-disubstituted pyridin-3-yl C-nucleosides.
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The heterocyclic ring of 4-substituted-1,8-naphthalimides is NOT inert to nucleophilic attack, contrary to earlier reports

Org. Biomol. Chem., 2013, 11,4390-4396
DOI: 10.1039/C3OB40639C, Paper

Ryan K. McKenney, Leah L. Groess, Kyle M. Kopidlansky, Kelsey L. Dunkle, David E. Lewis
The heterocyclic ring of N-aryl-4-chloro-1,8-naphthalimides, reported to be resistant to nucleophilic attack, reacts with primary amine nucleophiles at room temperature to give 4-chloro-N-alkyl-1,8-naphthalimides.
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CuI-catalyzed and air promoted oxidative cyclization for one-pot synthesis of polyarylated oxazoles

Org. Biomol. Chem., 2013, 11,4304-4307
DOI: 10.1039/C3OB40657A, Communication

Ping Hu, Qiang Wang, Yizhe Yan, Shuai Zhang, Baiqun Zhang, Zhiyong Wang
A CuI-catalyzed and air promoted oxidative dehydrogenation domino process of benzylamine and benzil derivatives has been developed. A series of oxazoles are obtained at room temperature.
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Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene

Org. Biomol. Chem., 2013, 11,4340-4349
DOI: 10.1039/C3OB40515J, Paper

Jaime Garcia-Hartjes, Silvia Bernardi, Carel A. G. M. Weijers, Tom Wennekes, Michel Gilbert, Francesco Sansone, Alessandro Casnati, Han Zuilhof
We report one of the most potent known cholera toxin inhibitors. It consists of a calix[5]arene scaffold presenting five GM1 ganglioside oligosaccharides and matches the valency of the toxin binding domain.
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Taming furfuryl cations for the synthesis of privileged structures and novel scaffolds

Org. Biomol. Chem., 2013, 11,4299-4303
DOI: 10.1039/C3OB40814K, Communication

Seema Dhiman, S. S. V. Ramasastry
Furfuryl cations are generated via a highly efficient bismuth-catalyzed reaction of furfuryl alcohols. This systematic study provides insights on the reactivity profile of furfuryl cations in novel C-C, C-N, C-O and C-S bond forming reactions, thus providing access to a diverse array of building blocks for further manipulations.
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Palladium-catalyzed conjugate addition of arylsulfonyl hydrazides to [small alpha],[small beta]-unsaturated ketones

Org. Biomol. Chem., 2013, 11,4295-4298
DOI: 10.1039/C3OB40518D, Communication

Wen Chen, Hui Chen, Fuhong Xiao, Guo-Jun Deng
A palladium-catalyzed desulfitative-denitrogenative conjugate addition of arylsulfonyl hydrazides to [small alpha],[small beta]-unsaturated ketones is described.
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Convenient in situ generation of various dichlorinating agents from oxone and chloride: diastereoselective dichlorination of allylic and homoallylic alcohol derivatives

Org. Biomol. Chem., 2013, 11,4312-4315
DOI: 10.1039/C3OB40670A, Communication

Jingyun Ren, Rongbiao Tong
Safe and convenient in situ generation of various chlorinating agents from oxone and chloride for dichlorination of functionalized alkenes.
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Chemical-genetic identification of the biochemical targets of polyalkyl guanidinium biocides

Org. Biomol. Chem., 2013, 11,4359-4366
DOI: 10.1039/C3OB40593A, Paper

Drew Bowie, Paria Parvizi, Dustin Duncan, Christopher J. Nelson, Thomas M. Fyles
Chemical genetic profiling in yeast defines the biochemical processes targeted by guanidinium-based biocides.
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Bu4NI-catalyzed decarboxylative acyloxylation of an sp3 C-H bond adjacent to a heteroatom with [small alpha]-oxocarboxylic acids

Org. Biomol. Chem., 2013, 11,4308-4311
DOI: 10.1039/C3OB40748A, Communication

Shuai Zhang, Li-Na Guo, Hua Wang, Xin-Hua Duan
A novel metal-free decarboxylative acyloxylation of an sp³ C-H bond in formamides and ethers has been explored. A variety of N-acyloxymethylamides and [small alpha]-acyloxy ethers could be easily synthesized using this method.
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The phenacyl group as an efficient thiol protecting group in a peptide condensation reaction by the thioester method

Org. Biomol. Chem., 2013, 11,4405-4413
DOI: 10.1039/C3OB40644J, Paper

Hidekazu Katayama, Hironobu Hojo
We synthesized model peptides by the thioester condensation method using the phenacyl group as a Cys-protecting group.
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Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase: synthesis, biological evaluation and molecular docking

Org. Biomol. Chem., 2013, 11,4367-4378
DOI: 10.1039/C3OB40368H, Paper

Liang Xi, Jian-Qiang Zhang, Zhi-Cheng Liu, Ji-Hong Zhang, Ju-Fang Yan, Yi Jin, Jun Lin
A series of novel 5-anilinoquinazoline derivatives were prepared. Some of them showed significant VEGR-2 kinase inhibition and antiproliferative activity on cancer cells; compound 6f showed the most potent inhibitory activity toward VEGFR-2 kinase and its IC₅₀ value was 0.012 [small mu ]M.
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Global and local reactivity indices for electrophilic/nucleophilic free radicals

Org. Biomol. Chem., 2013, 11,4350-4358
DOI: 10.1039/C3OB40337H, Paper

Luis R. Domingo, Patricia Perez
While the global electrophilicity [small omega][degree] and nucleophilicity N[degree] indices account for polar reactivity of FRs, the radical Parr function P^[degree]_k accounts for the local reactivity.
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AApeptides as a new class of antimicrobial agents

Org. Biomol. Chem., 2013, 11,4283-4290
DOI: 10.1039/C3OB40444G, Perspective

Youhong Niu, Haifan Wu, Yaqiong Li, Yaogang Hu, Shruti Padhee, Qi Li, Chuanhai Cao, Jianfeng Cai
Herein we describe the development of AApeptides as a new class of peptidomimetics that mimic natural antimicrobial peptides.
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Redox control of molecular motions in bipyridinium appended calixarenes

Org. Biomol. Chem., 2013, 11,4383-4389
DOI: 10.1039/C3OB40356D, Paper

Adriana Iordache, Ramu Kannappan, Estelle Metay, Marie-Christine Duclos, Stephane Pellet-Rostaing, Marc Lemaire, Anne Milet, Eric Saint-Aman, Christophe Bucher
The signatures of a series of viologen-based [small pi]-dimers have been shown to be linked to the extent of overlapping between both [small pi]-orbitals.
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Stereoselective direct reductive amination of ketones with electron-deficient amines using Re2O7/NaPF6 catalyst

Org. Biomol. Chem., 2013, 11,4379-4382
DOI: 10.1039/C3OB40918J, Paper

Braja Gopal Das, Prasanta Ghorai
The direct reductive amination (DRA) of ketones with electron-deficient amines (EDA) has been developed using catalytic Re₂O₇/NaPF₆ and stoichiometric silanes as the hydride source. Highly diastereoselective (up to 1 : 99) DRAs were observed from 2-alkyl cyclohexanones.
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Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

Org. Biomol. Chem., 2013, 11,4414-4418
DOI: 10.1039/C3OB40212F, Paper

Nicolaos Avlonitis, Manuelle Debunne, Tashfeen Aslam, Neil McDonald, Chris Haslett, Kevin Dhaliwal, Mark Bradley
A series of highly specific, internally quenched fluorescent reporters were synthesised which allowing the rapid and sensitive analysis of HNE.
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CuO/SiO2 as a simple, effective and recoverable catalyst for alkylation of indole derivatives with diazo compounds

Org. Biomol. Chem., 2013, 11,4327-4332
DOI: 10.1039/C3OB40264A, Paper

Jose M. Fraile, Karel Le Jeune, Jose A. Mayoral, Nicoletta Ravasio, Federica Zaccheria
CuO/SiO₂ efficiently catalyzes the reaction of indoles with diazo compounds, leading to a formal insertion. The catalyst is recoverable at least 4 times.
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In-peptide synthesis of di-oxazolidinone and dehydroamino acid-oxazolidinone motifs as [small beta]-turn inducers

Org. Biomol. Chem., 2013, 11,4316-4326
DOI: 10.1039/C3OB40357B, Paper

Rossella De Marco, Arianna Greco, Sebastiano Rupiani, Alessandra Tolomelli, Claudia Tomasini, Silvia Pieraccini, Luca Gentilucci
Constraining a peptide in a snap: linear peptides 1 give rise in a single step to sequences Oxd²-Oxd³ (2) or [capital Delta]Abu²-Oxd³ (3), characterized by well defined extended or folded conformations.
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Hybrid photoactive fullerene derivative-ruboxyl nanostructures for photodynamic therapy

Org. Biomol. Chem., 2013, 11,4397-4404
DOI: 10.1039/C3OB40136G, Paper

Alexander I. Kotelnikov, Alexander Yu. Rybkin, Ekaterina A. Khakina, Alexey B. Kornev, Alexander V. Barinov, Nikolay S. Goryachev, Anastasiya V. Ivanchikhina, Alexander S. Peregudov, Vyacheslav M. Martynenko, Pavel A. Troshin
Investigation of the photophysical properties and photodynamic action of two novel water soluble hybrid molecular structures based on [60]fullerene dyads bearing covalently attached residues of anthracycline antibiotic "ruboxyl".
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Efficient One-Step Synthesis of Pyrrolo[3,4-c]quinoline-1,3-dione Derivatives by Organocatalytic Cascade Reactions of Isatins and [small beta]-Ketoamides

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40791H, Paper

Yong Rok Lee, Likai Xia
We describe an efficient one-step synthesis of pyrrolo[3,4-c]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and [small beta]-ketoamides. It's the first direct conversion of isatins to pyrrolo[3,4-c]quinolinedione derivatives via...
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Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40536B, Paper

Shinya Kodani, Joanna Bicz, Lijiang Song, Robert J. Deeth, Mayumi Ohnishi-Kameyama, Mitsuru Yoshida, Kozo Ochi, Gregory L. Challis
Scabichelin was identified as the product of a cryptic nonribosomal peptide synthetase, providing new insights into Streptomyces scabies iron acquisition.
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The Mechanism for the Hydrogenation of Ketones Catalyzed by Knolker's Iron-Catalyst

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40936H, Paper

Xi Lu, Yawei Zhang, Peng Yun, Mingtao Zhang, Tonglei Li
Knolker's iron-based catalysts have some value in "green" transformations given the relatively low toxicity of iron compared to more commonly used precious-metal catalysts. Density functional methods have been used to...
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Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40595H, Communication

Kai Liu, Datong Zhang, Jeremy Chojnacki, Yuhong Du, Haian Fu, Steven Grant, Shijun Zhang
In our efforts to develop effective treatment agents for human multiple myeloma (MM), a series of hybrid molecules based on the structures of thalidomide (1) and curcumin (2) were designed,...
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The chemical synthesis of [small beta]-arabinofuranosyl containing oligosaccharides derived from plant cell wall extensins

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40958A, Paper

Sophon Kaeothip, Geert-Jan Boons
Extensins are plant-derived glycoproteins that are densely modified by oligo-arabinofuranosides linked to hydroxyproline residues. These glycoproteins have been implicated in many aspects of plant growth and development. Here, we describe...
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Straightforward Synthesis of Non-Natural L-Chalcogen and L-Dichalcogen N-Boc-Protected-ɣ-Amino Acid Derivatives

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40879E, Paper

Antonio Luiz Braga, Cristiane Y Kawasoko, Oscar E. D. Rodrigues, Patricia Foletto, Luciano Dornelles, Ricardo S Schwab
The synthesis of new chiral seleno-, telluro-, and thio-N-Boc-ɣ-amino acids is described herein. These new compounds were prepared through a simple and short synthetic route, from the inexpensive and commercially-available...
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Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40861B, Paper

Walter Balansa, Robiul Islam, Frank Fontaine, Andrew M. Piggott, Hua Zhang, Xue Xiao, Timothy I. Webb, Daniel F. Gilbert, Joseph W. Lynch, Robert J. Capon
Three Australian sponges (Psammocinia spp.), yielded five new ircinianins including a potent and selective [small alpha]3 GlyR potentiator and a selective [small alpha]1 GlyR potentiator.
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Highly efficient alpha-C-sialylation promoted by (p-Tol)2SO/Tf2O with N-Acetyl-5-N,4-O-oxazolidione protected thiosialoside as donor

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40876K, Paper

Zhen-yuan Gu, Xiao-tai Zhang, Jiaxin Zhang, Guo-wen Xing
Based on preactivation protocol with (p-Tol)2SO/Tf2O, a practical, straightforward, and high-yielding synthesis of alpha-sialyl C-glycoside was accomplished in the coupling of N-Acetal-5-N,4-O-oxazolidione protected thiosialoside with various trimethylsilyl enol ethers and...
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Novel amino acids: synthesis of furoxan and sydnonimine containing amino acids and peptides as potential nitric oxide releasing motifs

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB41047A, Paper

Andrew Nortcliffe, Nigel P. Botting, David O'Hagan
Amino acids are prepared with furoxan and sydnonimine ring systems in their side chains and orthogonal protecting group strategies illustrate that they can be built into peptides. The heterocyclic side chains are known to be metabolised to nitric oxide (NO) offering a strategy for the construction of peptides for the localisation of NO in cells.
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An extreme vertices mixture design approach to the optimisation of 1,2,3-trichlorobenzene specific molecularly imprinted polymers

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB27375J, Paper

Dougal Cleland, Adam McCluskey
Traditional approaches to molecularly imprinted polymer (MIP) design and optimisation typically afford a template (T) : functional monomer (FM) : crosslinker (CL) ratio of 1 : 2 : 20 to 1 : 4 : 20.
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An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40924D, Paper

Sabesan Yoganathan, Ning Yin, Yong He, Michael F. Mesleh, Yu Gui Gu, Scott J. Miller
Herein we report a direct and efficient method for the synthesis of four new carboxylate-isostere analogs of daptomycin.
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Organocatalytic functionalization of heteroaromatic N-oxides with C-nucleophiles using in situ generated onium amide bases

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40782A, Communication

Kiyofumi Inamoto, Yuta Araki, Shoko Kikkawa, Misato Yonemoto, Yoshiyuki Tanaka, Yoshinori Kondo
Organocatalytic functionalization of heteroaromatic N-oxides with C-nucleophiles has been achieved by using in situ generated onium amide bases.
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Copper-catalyzed oxidative condensation of [small alpha]-oxocarboxylic acids with formamides: synthesis of [small alpha]-ketoamides

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40787J, Communication

Hua Wang, Li-Na Guo, Xin-Hua Duan
A copper-catalyzed coupling of [small alpha]-oxocarboxylic acids with formamides is reported. This simple method provides a practical approach toward the synthesis of [small alpha]-ketoamides with a variety of functional groups.
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The use of effective fragment potentials in the design and synthesis of molecularly imprinted polymers for the group recognition of PCBs

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB27168D, Paper

Dougal Cleland, Adam McCluskey
Effective fragment potential (EFP) molecular modeling approaches have been applied for the first time to the rational design of molecularly imprinted polymers for the group recognition of selected polychlorinated biphenyls (PCBs).
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Chemoselective Synthesis of Tetrasubstituted Furans via Intramolecular Wittig Reactions: Mechanism and Theoretical Analysis

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40858B, Paper

Yu-Ting Lee, Yen-Te Lee, Chia-Jui Lee, Chia-Ning Sheu, Bo-Yu Lin, Jeng-Han Wang, Wenwei Lin
An efficient synthesis of tetrasubstituted furans was achieved from the corresponding [small alpha],[small beta]-unsaturated ketone derivatives, acid chlorides, and Bu3P in the presence of Et3N via a chemoselective intramolecular Wittig reaction as...
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Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40809D, Communication

Detcho A. Stoyanovsky, Melanie J. Scott, Timothy R. Billiar
In this study, we present experimental evidence that glutathione acts in concert with human thioredoxin type 1 in the denitrosation of cytosolic S-nitrosoproteins (PSNOs) from HepG2 cells.
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Organocatalytic asymmetric synthesis of [small beta]3-amino acid derivatives

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40917A, Perspective

Sun Min Kim, Jung Woon Yang
[small beta]³-Amino acid derivatives are an essential resource for pharmaceutical production, medicinal chemistry, and biochemistry. In this article, recent developments in versatile organocatalysis for asymmetric synthesis of [small beta]³-amino acid derivatives will be presented.
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A stereoselective approach for the southeast segment (C1-C16) of (+)-sorangicin A

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40985F, Paper

Y. Sridhar, P. Srihari
The stereoselective protective group-free synthesis of the C1-C16 fragment of (+)-sorangicin A consisting of a dihydropyran subunit with a chiral alkyl substituent is achieved.
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NHC-mediated cross-coupling of sugar-derived cyclic nitrones with enals: general and efficient synthesis of polyhydroxylated pyrrolizidines and indolizidines

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40696B, Paper

Wen-Yuan Xu, Ren Iwaki, Yue-Mei Jia, Wei Zhang, Atsushi Kato, Chu-Yi Yu
A general and efficient method for the synthesis of polyhydroxylated pyrrolizidines and indolizidines has been developed based on the NHC-catalyzed cross-coupling of sugar-derived cyclic nitrones with enals.
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Photocycloadditions of substituted oxazoles with isoquinoline-1,3,4-trione-chemo-, regio-, diastereoselectivities and transformation of the photocycloadducts

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40645H, Paper

Chengmei Huang, Heng Jiang, Ru-zhi Wang, Quah-Ching Kheng, Hoong- Kun Fun, Yan Zhang
Photoreactions of isoquinoline-1,3,4-triones and oxazoles with different substitution groups were found to give different chemo-, regio- and diastereoselectivities. The substitution group at the C5 on the oxazole ring showed great...
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Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues - Synthesis and biochemical characterization

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40842F, Paper

Marcel Hollenstein
Modified nucleoside triphosphates (dAHsTP, dUPOHTP, and dCValTP) bearing imidazole, hydroxyl, and carboxylic acid residues connected to the purine and pyrimidine bases through alkyne linkers were prepared. These modified dNTPs were...
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Porphothionolactones: synthesis, structure, physical, and chemical properties of a chemodosimeter for hypochlorite

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40758F, Paper

Yi Yu, Brigitte Czepukojc, Claus Jacob, Yue Jiang, Matthias Zeller, Christian Bruckner, Jun-Long Zhang
Lawesson's reagent converts the highly fluorescent porpholactones to dimly fluorescing thionoporpholactones; this reaction is reversed specifically by hypochlorite.
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Manganese-catalyzed aerobic dehydrogenative cyclization toward ring-fused indole skeletons

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40855H, Communication

Kounosuke Oisaki, Junpei Abe, Motomu Kanai
The first example of manganese(III)-catalyzed aerobic dehydrogenative cyclization producing ring-fused indole skeletons is described.
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Cyclization-Carbonylation-Cyclization Coupling Reaction of [small alpha],[small beta]-Alkynic Hydrazones with Palladium(II)-Bisoxazoline Catalyst

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40913A, Paper

Taichi Kusakabe, Hiroshi Sagae, Keisuke Kato
A cyclization-carbonylation-cyclization coupling reaction (CCC-coupling reaction) of [small alpha],[small beta]-alkynic hydrazones, catalyzed by (box)Pd(II) complexes, afforded symmetrical ketones bearing two pyrazole groups in good to excellent yields. This method is applicable to...
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Tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB40642C, Communication

Ying Fu, Yanshou Yang, Helmut M. Hugel, Zhengyin Du, Kehu Wang, Danfeng Huang, Yulai Hu
Triorganoaluminium reagents are versatile reagents in the tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to ketones.
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Macrocycle synthesis by trimerization of boronic acids around a hexaol template, and recognition of polyols by resulting macrocyclic oligoboronic acids

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40554K, Paper

Dennis Stoltenberg, Ulrich Luening
2,6-Bis(alkenyloxy) substituted arylboronic acids can be cyclotrimerized with the help of a hexaol as template. First, the boronic acids are assembled by boronic ester formation with hexahydroxy-bicyclo[2.2.2]octane. Next, the resulting...
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Design and evaluation of improved magnetic stir bars for single-mode microwave reactors

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40790J, Paper

David Obermayer, Markus Damm, C Oliver Kappe
Magnetic stirring in sealed cylindrical vessels designed for use in single-mode microwave instruments is typically less than optimal, and not comparable to the efficient agitation that can generally be obtained...
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The water-soluble inclusion complex of Ilexgenin A with [small beta]-cyclodextrin polymer-a novel lipid-lowering drug candidate

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40715B, Paper

Chang Liu, Wang Zhang, Qiang Wang, Yun Sun, Guowang Diao
A new water-soluble inclusion complex of Ilexgenin A (IGA) with [small beta]-cyclodextrin polymer (CDP) was prepared by a facile strategy and characterized by 1H NMR spectroscopy, FT-IR spectra, and UV-vis spectroscopy....
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Radiofluorination of diaryliodonium tosylates under aqueous-organic and cryptand-free conditions

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40742J, Paper

Joong-hyun Chun, Sanjay Telu, Shui-Yu Lu, Victor W Pike
Positron emission tomography (PET) has growing importance as a molecular imaging technique for clinical research and drug development. Methods for producing PET radiotracers utilizing cyclotron-produced [¹⁸F]fluoride ion (t_1/2 = 109.7...
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Chemoselective fragment condensation between peptide and peptidomimetic oligomers

Org. Biomol. Chem., 2013, 11,4142-4146
DOI: 10.1039/C3OB40606G, Communication

Paul M. Levine, Timothy W. Craven, Richard Bonneau, Kent Kirshenbaum
Peptoid oligomers containing C-terminal salicylaldehyde esters can be ligated to peptides bearing N-terminal serine or threonine residues, establishing native amide linkages between unprotected oligomer fragments.
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Efficient catalysts for asymmetric Mannich reactions

Org. Biomol. Chem., 2013, 11,4207-4213
DOI: 10.1039/C3OB40681D, Paper

Michal Rachwalski, Tim Leenders, Sylwia Kaczmarczyk, Piotr Kielbasinski, Stanislaw Lesniak, Floris P. J. T. Rutjes
Efficient chiral catalysts for asymmetric Mannich reactions have been developed. The reaction conditions have been optimized by invoking ultrasonication.
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Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents

Org. Biomol. Chem., 2013, 11,4154-4163
DOI: 10.1039/C3OB40654G, Paper

Kyriacos C. Nicolaou, Roman A. Valiulin
Synthesis and biological evaluation of a series of paclitaxel analogs revealed a number of potent antitumor agents, including 21a, 23, 27, and 29.
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Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

Org. Biomol. Chem., 2013, 11,4147-4153
DOI: 10.1039/C3OB40489G, Communication

Marie-Celine Frantz, Erin M. Skoda, Joshua R. Sacher, Michael W. Epperly, Julie P. Goff, Joel S. Greenberger, Peter Wipf
The SAR of new mitochondrially targeted nitroxide conjugates was investigated and fluorophore-tagged analogs provided the opportunity for visualization in mitochondria.
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Aniline mediated oxidative C-C bond cleavage of [small alpha]-alkoxy aldehydes in air and a model reaction for the synthesis of [small alpha]-(D)-amino acid derivatives

Org. Biomol. Chem., 2013, 11,4138-4141
DOI: 10.1039/C3OB40685G, Communication

Bin Hu, Yunfeng Li, Zhongjun Li, Xiangbao Meng
A clean procedure for C-C cleavage provides a route from amino acid catalysis to amino acid ester!
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Total syntheses of oroidin, hymenidin and clathrodin

Org. Biomol. Chem., 2013, 11,4133-4137
DOI: 10.1039/C3OB40668G, Communication

Sivappa Rasapalli, Venkatreddy Kumbam, Abasaheb N. Dhawane, James A. Golen, Carl J. Lovely, Arnold L. Rheingold
The total syntheses of oroidin, hymenidin and clathrodin are reported via the intermediacy of a novel acyl imidazo[1,2-a]pyrimidine derivative that obviates the need for expensive guanidine reagents and 2-aminoimidazole synthons and offers the opportunity for scale up.
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The water-soluble argentivorous molecule: Ag+-[small pi] interactions in water

Org. Biomol. Chem., 2013, 11,4265-4270
DOI: 10.1039/C3OB40125A, Paper

Yoichi Habata, Yoko Okeda, Mari Ikeda, Shunsuke Kuwahara
Ag⁺-[small pi] interactions between Ag⁺ ions and a water-soluble tetra-armed cyclen bearing aromatic side-arms (tetracesium 4,4[prime or minute],4[prime or minute][prime or minute],4[prime or minute][prime or minute][prime or minute]-((1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(methylene))tetrabenzoate, Cs₄L) are reported.
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The chemical fate of paroxetine metabolites. Dehydration of radicals derived from 4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine

Org. Biomol. Chem., 2013, 11,4232-4239
DOI: 10.1039/C3OB40219C, Paper

Davor Sakic, Florian Achrainer, Valerije Vrcek, Hendrik Zipse
The light-induced dehydration of paroxetine metabolites is a radical-mediated process which can be modeled computationally. Several structures, not considered earlier, are proposed as probable photoproducts in aqueous environments.
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Cross metathesis of allyl alcohols: how to suppress and how to promote double bond isomerization

Org. Biomol. Chem., 2013, 11,4194-4206
DOI: 10.1039/C3OB40167G, Paper

Bernd Schmidt, Sylvia Hauke
Redox isomerization as a consecutive reaction in the cross metathesis of allyl alcohols can be effectively suppressed or deliberately promoted to obtain [gamma]-hydroxy enoates or [gamma]-oxo-esters selectively.
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Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase

Org. Biomol. Chem., 2013, 11,4214-4219
DOI: 10.1039/C3OB40493E, Paper

Cheng-Hsiang Chang, Hao-Yu Wen, Wen-Shiang Shie, Ching-Ting Lu, Meng-Erh Li, Yuan-Ting Liu, Wen-Hsuan Li, Tung-Kung Wu
An ERG7^H234W/Y510W double mutant generates achilleol A as the sole product, supporting the concept of reverse evolution of triterpene cyclase.
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First studies directed towards the diastereoselective synthesis of the BCD tricyclic core of brownin F

Org. Biomol. Chem., 2013, 11,4178-4185
DOI: 10.1039/C3OB40363G, Paper

Fabien Rodier, Jean-Luc Parrain, Gaelle Chouraqui, Laurent Commeiras
The BCD tricyclic core of brownin F was prepared in eight synthetic operations for the first time. Our synthesis features a diastereo-, chemo- and regioselective intramolecular [3 + 2] cycloaddition between a cyclic carbonyl ylide and a [gamma]-alkylidenebutenolide.
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Peptide-LNA oligonucleotide conjugates

Org. Biomol. Chem., 2013, 11,4240-4249
DOI: 10.1039/C3OB40786A, Paper

I. Kira Astakhova, Lykke Haastrup Hansen, Birte Vester, Jesper Wengel
Herein we reveal how the CuAAC click reaction on a 2[prime or minute]-alkyne-2[prime or minute]-amino-LNA scaffold can be applied for preparation of peptide-oligonucleotide conjugates demonstrating high target binding affinity and selectivity, and remarkable stability in human serum.
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A squaraine-based red emission off-on chemosensor for biothiols and its application in living cells imaging

Org. Biomol. Chem., 2013, 11,4258-4264
DOI: 10.1039/C3OB40502H, Paper

Xiao-Dong Liu, Ru Sun, Jian-Feng Ge, Yu-Jie Xu, Ying Xu, Jian-Mei Lu
A squaraine-based fluorescent turn-on red-emitting probe for cysteine and homocysteine in biological conditions.
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Analysis of designed [small beta]-hairpin peptides: molecular conformation and packing in crystals

Org. Biomol. Chem., 2013, 11,4220-4231
DOI: 10.1039/C3OB25777K, Paper

Subrayashastry Aravinda, Upadhyayula S. Raghavender, Rajkishor Rai, Veldore V. Harini, Narayanaswamy Shamala, Padmanabhan Balaram
Crystal structure determination of several designed [small beta]-hairpin peptides reveal three broad modes of association: parallel packing, antiparallel packing and orthogonal packing..
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Cooperative enhancement of optical nonlinearities in a porphyrin derivative bearing a pyrimidine chromophore at the periphery

Org. Biomol. Chem., 2013, 11,4250-4257
DOI: 10.1039/C3OB40323H, Paper

Aijian Wang, Lingliang Long, Suci Meng, Xiufen Li, Wei Zhao, Yinglin Song, Marie P. Cifuentes, Mark G. Humphrey, Chi Zhang
Enhanced optical nonlinearities were observed for compound 6 due to a combination of different nonlinear mechanisms.
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Aerobic oxidation of indole carbinols using Fe(NO3)3[middle dot]9H2O/TEMPO/NaCl as catalysts

Org. Biomol. Chem., 2013, 11,4186-4193
DOI: 10.1039/C3OB40226F, Paper

Jinxian Liu, Shengming Ma
A practical method for the aerobic oxidation of indole carbinols using Fe(NO₃)₃[middle dot]9H₂O/TEMPO/NaCl as catalysts under mild conditions was developed, affording aldehydes or ketones in good to excellent yields.
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Photoresponsive two-component organogelators based on trisphenylisoxazolylbenzene

Org. Biomol. Chem., 2013, 11,4164-4170
DOI: 10.1039/C3OB00041A, Paper

Takeharu Haino, Yuko Hirai, Toshiaki Ikeda, Hiroshi Saito
New photoresponsive two-component organogels were developed by photochromic tris(phenylisoxazolyl)benzene and bispyridine derivatives.
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Direct amide formation using radiofrequency heating

Org. Biomol. Chem., 2013, 11,4171-4177
DOI: 10.1039/C2OB26930A, Paper

Thomas K. Houlding, Kirill Tchabanenko, Md. Taifur Rahman, Evgeny V. Rebrov
We present a simple method for the direct and solvent-free formation of amides from carboxylic acids and amines using radiofrequency heating.
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Synthesis and properties of T-shaped organic conjugates based on 3,6-diarylpyridazine-fused tetrathiafulvalene

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40704G, Paper

Ningjuan Zheng, Hongda Li, Guangyan Sun, Ke-Li Zhong, Bingzhu Yin
A facile synthetic approach to the [small pi]-expanded tetrathiafulvalene derivatives is described. The Suzuki reaction of 3,6-dichloropyridazine-fused tetrathiafulvalenes with phenyl boronic acid or biphenyl boronic acid gave a series of novel...
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E-factor minimized hydrophosphonylation of aldheydes catalyzed by polystyryl-BEMP under solvent-free conditions

Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40767E, Paper

Luigi Vaccaro, Daniela Lanari, Ferdinando Pizzo, simona bonollo, Tommaso angelini
An efficient protocol for the hydrophosphonylation of aromatic and aliphatic aldheydes catalyzed by PS-BEMP under solvent-free conditions (SolFC) has been reported. Addition reactions were performed by using equimolar amounts of...
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