RSC - Chem. Sci. latest articles

Salicylhydroxamic acid as an electro-responsive and switchable adhesive molecule

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC07881D, Edge Article

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Kan Wang, Vedika Khare, Abhilash Arjan Das, Fatemeh Razaviamri, Bruce P Lee
ABSTRACT: This study investigated salicylhydroxamic acid (SHAM) as a new electro-responsive, switchable adhesive molecule for wet adhesive contact. SHAM-containing polymer was synthesized and evaluated using a customized Johnson-Kendall-Roberts (JKR) contact...
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Label-Free Optical Detection of Protein Acetylation using UV-Vis Charge Transfer Spectra

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC09293K, Edge Article

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Himanshi M. Devi, Apoorva Badaya, arijit maity, Simangka B Saikia, Ravindra Venkatramani, Rajaram Swaminathan
We report the first spectroscopic detection of protein acetylation in solution using UV-Vis Protein Charge transfer spectra (ProCharTS). Acetylation is an important post-translational modification (PTM) that modulates diverse cellular processes,...
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Orthogonal cation and anion template-directed synthesis of a heteroditopic [3]catenane for ion-pair recognition

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC05942A, Edge Article

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Hui Min Tay, Andrew Docker, Antonio J. Martínez-Martínez, Paul D. Beer
The first orthogonal template strategy for the synthesis of higher order interlocked structures is described. Orthogonal cation and anion templates were employed in a stepwise fashion to construct a hetero[3]catenane...
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Machine learning potential for modelling dynamic hydrogen bond networks in MOF MIL-120

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC09058J, Edge Article

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Xin Jin, Yutao Li, Kelian Dietmar Marc Gaedecke, Xiaoqi Zhang, Berend Smit
Metal-organic frameworks (MOFs) are porous materials with the potential for gas adsorption and separation technologies due to their tunable structural and chemical characteristics. However, simulating gas adsorption isotherms in MOFs...
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Tuneable electronic coupling in linked bis(cubane) cobalt-oxo clusters

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09713D, Edge Article

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Vincent J. P. Maddi, T. Don Tilley
Dimeric complexes of cobalt-oxo cubane clusters relevant to water-oxidation are synthesized and demonstrated to possess inter-cluster electronic coupling via electrochemistry.
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A protein-based model of carbon monoxide dehydrogenase exhibits tunable covalency across cluster oxidation and ligand-bound states

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00023A, Edge Article

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Luke C. Lewis, Prajakta Badve, Itzel P Vaca, Pujan Ajmera, Yuri Lee, Anastassia Alexandrova, Katlyn Meier, Hannah S. Shafaat
The nickel-containing carbon monoxide dehydrogenase (CODH) uses a unique heterometallic [NiFe₄S₄] cluster active site, called the C-cluster, to catalyze the reversible reduction of carbon dioxide (CO₂) to carbon monoxide (CO)...
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Activation Volumes Associated with Excited-State Electron Transfer Across Amidinium‑Carboxylate Bridge

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00291A, Edge Article

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Daniel Langford, Rene Weiss, Marcel Krug, Maxence Urbani, Achim Zahl, Carolin Müller, Tim Clark, Tomás Torres, Dirk M. Guldi
Pressure was used to modulate interactions in an electron donor-acceptor system, composed of a zinc porphyrin (ZnP) and a fullerene (C₆₀), held together by an amidinium-carboxylate salt-bridge (ZnP‑H‧‧‧C₆₀). Two different...
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Conversion of trifluoromethyl into ester along with polyethers upcycling by cation-transfer catalyzed C–O/C–F metathesis

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC10208A, Edge Article

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Zhuojun Li, Xiangqian Shi, Dongke Zhang, Qian Wu
Ester and trifluoromethyl groups play crucial roles in chemistry and drug design. However, the implementation of interconvesion from trifluoromethyl into ester under wide condition is not an easy work because...
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Confined nanopores and hydrogen bonds of polyoxometalates for continuous electricity generation from fluctuating humidity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00287K, Edge Article

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Tuo Ji, WeiLin Chen, Fan Liao, ZhenHui Kang
A continuous humidity power generation strategy based on polyoxometalates (POMs) with confined nanopores and hydrogen bonds for effectively collecting water molecules and maintaining water adsorption gradient in fluctuating environmental humidity.
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How Solvent Activity and Solute Solvation Control Electrode Potentials: Quantitative Insights from Li⁺ Insertion into TiO₂

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00393A, Edge Article

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Ludivine K/Bidi, Tom Rocca, Lucie Chen, Andrea Gutierrez Schindler, B. Limoges, Véronique Balland
Tuning electrolyte salt concentration has emerged as a powerful strategy to enhance the performance of rechargeable batteries by mitigating parasitic side reactions. Here, we introduce a unified and quantitative validation...
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Organic Supramolecular Assemblage Confined Photoluminescence

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC10066F, Review Article

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Hengzhi Zhang, Yu Liu
Organic supramolecular hosts can selectively bond to small organic molecules with chromophores, inhibiting molecular motion and isolating quenching factors through spatial confinement, thereby enhancing fluorescence and phosphorescence emission and expanding...
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Large-scale protein conformational transitions revealed by weighted ensemble simulations and EPR

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC08971A, Edge Article

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Shramana Palit, Darian T. Yang, Xiaowei Bogetti, Anthony T. Bogetti, Olivia Wood, Sunil Saxena, Lillian T. Chong
Conformational exchange pathways of LAO binding protein revealed through an integrated EPR spectroscopy and weighted ensemble simulation approach.
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Resonator-based add-drop filters enabled by flexible polymorphic crystals with TADF-RTP motifs

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC08545D, Edge Article

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Pradip Pattanayak, Ankur Khapre, Shamim Ahmad, Avulu Vinod Kumar, Bishes Ray, Satendra Kumar, Chilla Malla Reddy, Rajadurai Chandrasekar, Pradipta Purkayastha
We demonstrate the use of yellow and green fluorescence (Y-FL and G-FL) obtained from polymorphic crystals as signals in an add-drop filter (P-ADF).
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Retraction: Supramolecular engineering cascade regulates NIR-II J-aggregates to improve photodynamic therapy

Chem. Sci., 2026, 17,6785-6785
DOI: 10.1039/D6SC90067D, Retraction

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Huizhe Wang, Huijia Liu, Wenqing Li, Shuai Li, Jiaqi Zhang, Jingzhe Zang, Li Liu, Peng Wang
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Symmetry-breaking charge separation in perylene diimide trimers: effects of aggregation and solvent polarity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09357K, Edge Article

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Lie Tian, Guangliu Ran, Shixuan Zheng, Wenkai Zhang
Symmetry-breaking charge separation (SB-CS) of a perylene diimide trimer occurs even in nonpolar solvent. In toluene, intermolecular aggregation enhances π–π interactions and promotes SB-CS, giving efficiency between that in chloroform and acetone.
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Correction: Suppressing nonradiative decay via molecular configuration control in Cu(I)–halide clusters enables the fabrication of highly efficient green and green-sensitized blue OLEDs

Chem. Sci., 2026, 17,6782-6782
DOI: 10.1039/D6SC90060G, Correction

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Xiao Li, Sai Guo, Xin Liu, Yu-Fu Sun, Dong-Hai Zhang, Hui Yang, Jia-Min Lu, Xu-Lin Chen
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Microenvironment regulation in nanomaterial synthesis

Chem. Sci., 2026, 17,6261-6282
DOI: 10.1039/D5SC08395H, Perspective

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Shuyi Pang, Yuanduo Li, Wenxia Xu, Hangkai Shi, Hongdong Li, Jingqi Chi, Jianping Lai, Lei Wang
This study shows that by precisely regulating local physicochemical conditions, spatial confinement, and external field assistance, the synthesis of nanomaterials is transformed from macroscopic mixing to microscopic precise control.
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Engineering manganese-based cathodes for low-cost and high-energy rechargeable batteries

Chem. Sci., 2026, 17,6345-6370
DOI: 10.1039/D5SC09895E, Review Article

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Hongyu Zhang, Tingzhou Yang, Quan Zhou, Xiaoen Wang, Zhongwei Chen
Strategies and advanced characterization techniques to improve the commercial viability of manganese-based cathode materials in lithium/sodium-ion batteries.
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Peptide cages: bioinspired supramolecular architectures for next-generation applications

Chem. Sci., 2026, 17,6301-6323
DOI: 10.1039/D5SC08607H, Review Article

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Simone Adorinni, Houyang Xu, Jonathan R. Nitschke, Silvia Marchesan
This review analyses peptide-based supramolecular cages, their design and applications.
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Architecting NIR-II metal supramolecular dyes—illuminating the path to precision medicine

Chem. Sci., 2026, 17,6283-6300
DOI: 10.1039/D6SC00523C, Perspective

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Fang Zhao, Qiao Song, Panxing Qiu, Xiaoxing Xiong, Youjia Tang, Yao Sun
This perspective outlines the design strategies of NIR-II metal supramolecular dyes. Applications in anticancer, antibacterial, and cardiovascular therapy, as well as bioimaging, are highlighted, along with challenges and future outlooks.
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Correction: Structural and spectroscopic basis of excitation energy transfer in microbial rhodopsins binding xanthophylls

Chem. Sci., 2026, 17,6783-6784
DOI: 10.1039/D6SC90054B, Correction

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Giacomo Salvadori, Piermarco Saraceno, Alisia Santomieri, Chris John, Laura Pedraza-González
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Microfluidic-mass spectrometry analysis of blood–brain barrier transport using engineered microparticle interfaces

Chem. Sci., 2026, 17,6371-6378
DOI: 10.1039/D5SC10112C, Edge Article

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Shiyu Chen, Yingrui Zhang, Zengnan Wu, Tianze Xie, Tong Xu, Yi Zhang, Xianli Meng, Jin-Ming Lin
A barrier-mimetic analytical interface integrating multicellular blood–brain barrier particles with online metabolite detection enables dynamic interrogation of permeability-metabolism coupling for drug screening.
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Recent advances in small-molecule fluorescent probes for simultaneous dual detection of HClO/ClO− and analytes/microenvironment

Chem. Sci., 2026, 17,6324-6344
DOI: 10.1039/D5SC08843G, Review Article

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Yongqing Zhou, Mei Yan, Hosoowi Lee, Juyoung Yoon
This review offers a comprehensive summary of dual-responsive small-molecule fluorescent probes for simultaneous monitoring of HClO/ClO⁻ and analytes/microenvironment in living systems.
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Vibrational snapshots of ultrafast C–H bond photoactivation inside a water-soluble nanocage

Chem. Sci., 2026, 17,6390-6401
DOI: 10.1039/D5SC05247E, Edge Article

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Sunandita Paul, Shashi, Ankita Das, Dooshaye Moonshiram, Jyotishman Dasgupta
Photoactivation of C–H bonds inside enzyme-like nanocavities can enable organic transformations in water. Here we reveal structural dynamics of photoinduced PCET leading to C–H activation in a water-soluble nanocage.
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Active control of forward/backward charge transfer in Z-scheme water splitting: manipulating electrostatic affinity/repulsion between photocatalyst surface and electron mediator

Chem. Sci., 2026, 17,6379-6389
DOI: 10.1039/D5SC10049F, Edge Article

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Ren Itagaki, Akinobu Nakada, Hajime Suzuki, Osamu Tomita, Ryu Abe
A designed cationic/neutral charge-switchable Co complex as an electron mediator enabled much improved Z-scheme overall water splitting via manipulation of electrostatic interaction.
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NaCl interphase enables stable Na2.85Sb0.95W0.05S3.9Cl0.1-based all-solid-state sodium batteries

Chem. Sci., 2026, 17,6773-6781
DOI: 10.1039/D5SC09154C, Edge Article

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Zhanyou Feng, Liang Zhu, Enbo Qin, Ziman Weng, Jinghua Wu, Yong Li, Xiayin Yao
A W–Cl co-doping strategy in Na₃SbS₄ introduces Na⁺ vacancies and forms a NaCl interphase in situ, enabling high ionic conductivity and stable electrolyte–Na metal interfaces for all-solid-state sodium batteries.
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Surface curvature-directed in situ synthesis of ultrathin 2D MOFs on liquid metals for antibacterial applications

Chem. Sci., 2026, 17,6746-6754
DOI: 10.1039/D5SC09934J, Edge Article

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Jie Qi, Yihang Zhu, Chen Hang, Hao Tang, Lingmin Zhang, Xingyu Jiang
Liquid-metal curvature guides in situ growth of ultrathin MOF petals, yielding a composite with synergistic antibacterial activity against drug-resistant bacteria.
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A TADF sensitizer moiety decorated MR emitter for enhancing spin-flip and anti-ACQ

Chem. Sci., 2026, 17,6702-6709
DOI: 10.1039/D5SC08829A, Edge Article

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Xingtian Wang, Jianxing Chen, Songqian Ni, Yu Hu, Haorun Dai, Zezhu Xiao, Weiguo Zhu, Pi-Tai Chou, Xiugang Wu
MR-TADF emitters, mainly constructed from rigid fused polycyclic aromatic hydrocarbon (PAH) frameworks incorporating boron and nitrogen (B/N), have garnered significant attention.
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Unveiling bulk-to-interface electrolyte regulation for ultralong-life Zn-ion batteries

Chem. Sci., 2026, 17,6662-6676
DOI: 10.1039/D5SC09680D, Edge Article

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Yinyan Deng, Shuangtao Xu, Zhiping Peng, Linfeng Fei, Tao Wang
The carboxybetaine oligomer, showing strong interactions with water/Zn²⁺/Zn, achieves overall regulation from the bulk electrolyte to the anode interface, thereby suppressing side reactions and optimizing Zn deposition in aqueous zinc-ion batteries.
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Molecular dynamics of bicyclo[2.2.0]hex-2-ene ring opening and its polar derivative: allowed vs. forbidden pathways

Chem. Sci., 2026, 17,6644-6652
DOI: 10.1039/D5SC07711G, Edge Article

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Zhixin Qin, Qingyang Zhou, Rong-Kai Wu, K. N. Houk
We employed density functional theory, CCSD(T) and CASSCF computations, along with quasi-classical molecular dynamics simulations, to explore the ring opening of bicyclo[2.2.0]hex-2-ene and its 1-amino-4-cyano derivative.
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Synergistic strategy of interfacial ion channels and a cross-linked network in a composite electrolyte for dendrite-free sodium-metal batteries

Chem. Sci., 2026, 17,6593-6604
DOI: 10.1039/D5SC09295G, Edge Article

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Lei Zhai, Hanghang Dong, Haichao Wang, Yijie Duan, Zuo Liu, Shuang Yan, Chenguang You, Hao Yan, Xin Tan, Shuangqiang Chen
PPD-10 is a multi-component composite solid electrolyte featuring an in situ formed polymer network and well-dispersed NZSPO fillers. This design synergistically enhances ionic conductivity, mechanical strength, and interfacial stability.
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Implementing the design cues of dissociation dynamics and transmetalation in gallium(III) complexes to promote the anti-proliferative activity of ligands targeting intracellular iron(II) trafficking

Chem. Sci., 2026, 17,6546-6563
DOI: 10.1039/D5SC06084B, Edge Article

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Mahendiran Dharmasivam, Sadia Faiz, Busra Kaya, Tharushi P. Wijesinghe, Mediha Suleymanoglu, Mahan Gholam Azad, Vera Richardson, Ameer Fawad Zahoor, Danuta Kalinowski, William Lewis, Paul V. Bernhardt, Rukhsana Anjum, Des R. Richardson
Designing ligands for cancer has traditionally overlooked complex dissociation and transmetalation in enhancing efficacy.
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Visible-light-mediated synthesis of 2-oxetanes via Giese addition to α-oxy radicals

Chem. Sci., 2026, 17,6507-6512
DOI: 10.1039/D5SC07764H, Edge Article

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Matthew Liu, Elvis C. McFee, Corinna S. Schindler
A novel protocol for the synthesis of various alkyl and aryl 2-oxetanes leveraging a Giese addition to α-oxy radicals is disclosed, furnishing the desired products in up to 95% yield.
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cShot: spatial dynamic imaging of cell cycle-dependent miRNA heterogeneity using dynamic DNA patterns

Chem. Sci., 2026, 17,6524-6535
DOI: 10.1039/D5SC09638C, Edge Article

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Jie Zhou, Yuwei Sha, Ling'ou Qin, Fengying Yuan, Yu Ouyang, Yaqin Chai, Pu Zhang, Ruo Yuan
The ‘cShot’ DNA network enables real-time imaging of miRNA fluctuations across cell cycles. By integrating signal amplification, it effectively maps molecular heterogeneity in cancer cells, serving as a robust tool for dynamic biological profiling.
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Suppressing nonradiative decay via molecular configuration control in Cu(I)–halide clusters enables the fabrication of highly efficient green and green-sensitized blue OLEDs

Chem. Sci., 2026, 17,6477-6487
DOI: 10.1039/D5SC09307D, Edge Article

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Xiao Li, Sai Guo, Xin Liu, Yu-Fu Sun, Dong-Hai Zhang, Hui Yang, Jia-Min Lu, Xu-Lin Chen
Molecular configuration control in Cu(I)–halide clusters effectively suppresses nonradiative decay arising from excited-state distortions, enabling near-unity PLQY and the fabrication of highly efficient green and green-sensitized blue OLEDs.
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A dual-function molecule enables stable four-electron conversion and Zn deposition for high-capacity aqueous Zn–I2 batteries

Chem. Sci., 2026, 17,6536-6545
DOI: 10.1039/D6SC00182C, Edge Article

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Huiquan Zhang, Xueying Zhang, Dongmin Ma, Xinxin Cai, Mochi Lv, Hongting Yan, Junbo Niu, Weixing Song
L-lysine hydrochloride serves as a multifunctional additive, establishing a reversible four-electron 2I⁻/I₂/2I⁺ redox cycle for a capacity up to 502 mAh g⁻¹. It also prevents corrosion of the zinc anode and enhances cycling stability.
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Reductive desymmetric silylation of biaryl bis(triflates) enabled by a chiral nickel/picolinamide complex

Chem. Sci., 2026, 17,6710-6716
DOI: 10.1039/D5SC09250G, Edge Article

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Zhe Chen, Junjie Zhang, Chuan Wang
Reductive desymmetric silylation of biaryl triflates has been realized by employing a chiral nickel/picolinamide as a catalyst, providing highly enantioenriched axially chiral platform molecules for various downstream derivatizations.
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Photochemical cyclization of α-amino esters to access 3-azetidinones

Chem. Sci., 2026, 17,6766-6772
DOI: 10.1039/D5SC09994C, Edge Article

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Meemie U. Hwang, Achyut Gogoi, Matthew Scurria, Osvaldo Gutierrez, Karl A. Scheidt
A light-driven cyclization of readily available α-amino esters to 3-azetidinones has been developed.
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Identifying phase transitions in zeolitic imidazolate frameworks: microscopic insight from molecular simulations

Chem. Sci., 2026, 17,6734-6745
DOI: 10.1039/D5SC09468B, Edge Article

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Léna Triestram, François-Xavier Coudert
We present a computational methodology for the structural characterization of middle-range order in metal–organic frameworks (MOFs), based on analysis of their supramolecular rings and applicable to both crystalline and amorphous phases.
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Single-crystal-ordered-mesoporous metal nitrides without intrinsic Raman signals for highly sensitive SERS detection

Chem. Sci., 2026, 17,6632-6643
DOI: 10.1039/D5SC09344A, Edge Article

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Linchangqing Yang, Yijing Zong, Meng Yin, Wencai Yi, Junfang Li, Jie Lin, Qinghong Kong, Guangcheng Xi
A molten-salt/template strategy is proposed for the synthesis of transition metal nitrides featuring a single-crystal ordered mesoporous structure, which exhibits outstanding surface-enhanced Raman spectroscopy properties.
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Advanced oxidation processes at water/hydrophobic interfaces: energy-fluctuation mechanism and electron utilization quantification

Chem. Sci., 2026, 17,6564-6575
DOI: 10.1039/D5SC08827E, Edge Article

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Gaobo Xu, Fuling Li, Jin Ye, Shujun Zhang, Haiqin Ma, Guangdong Zhou, Cunyun Xu, Xiaofeng He, Xiude Yang, Qunliang Song
AOPs, traditionally limited to microscopic interfaces, are extended to a macroscopic water/hydrophobic interface without intense energy input. Flexoelectricity couples interfacial energy fluctuations with the energy required for charge transfer.
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Achieving (quasi)-monocoordination in metal complexes with an exceptionally bulky carbene ligand

Chem. Sci., 2026, 17,6500-6506
DOI: 10.1039/D5SC09514J, Edge Article

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Ludwig Zapf, Eric Rivard
A new N-heterocyclic carbene (NHC), ^BnITr, featuring exceptional steric bulk was synthesized and used for the isolation of (quasi-)monocoordinated metal cation complexes.
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Resolving sequential electron–proton transfer kinetics for electrochemical CO2 reduction at the Cu(100)/H2O interface via a quantum-classical framework

Chem. Sci., 2026, 17,6419-6425
DOI: 10.1039/D5SC07385E, Edge Article

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Yun Yang, Gang Fu
Multiscale simulations integrating machine learning and diabatic dynamics uncover the sequential electron transfer–proton transfer pathways in CO₂ electroreduction, highlighting the role of solvent fluctuations and quantum nuclear effects.
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From centrosymmetric (C4H8N5)(SbF4) to polar (C4H7N4O)(SbF4): a new UV nonlinear optical material achieved by functional group modulation

Chem. Sci., 2026, 17,6586-6592
DOI: 10.1039/D5SC09256F, Edge Article

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Zhi-Xiang Wang, Chun-Li Hu, Chuan-Fu Sun, Jiang-Gao Mao, Fang Kong
By functional group modulation strategy, polar (C₄H₇N₄O)SbF₄ was obtained. It demonstrates a strong SHG effect, a wide bandgap and a short phase matchable wavelength.
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3D self-assembly of cyclic peptides into multilayered nanosheets

Chem. Sci., 2026, 17,6727-6733
DOI: 10.1039/D5SC09489E, Edge Article

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Sandra Díaz, Adrian Sanchez-Fernandez, Juan R. Granja, Ignacio Insua, Javier Montenegro
A new cyclic peptide design that undergoes hierarchical one-, two-, and three-dimensional self-assembly to form supramolecular nanosheets made of nanotube layers.
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High brightness in bis(tri-isopropylsilyl)ethynyl-functionalized polycyclic aromatic hydrocarbons: localized representation versus Clar's model

Chem. Sci., 2026, 17,6653-6661
DOI: 10.1039/D5SC09423B, Edge Article

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Kais Dhbaibi, Huong Le Thi, Jérôme Marrot, Masahiro Hayakawa, Masashi Mamada, Michel Frigoli
Peri-fused PAHs converge to a single localized representation: cata-condensation increases aromatic sextets and amplifies brightness while linear extension adds cis-diene units and diminishes it.
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Pd-catalyzed stereoretentive synthesis of reversed C-acyl glycosides: access to rare L-sugars and higher-carbon sugars

Chem. Sci., 2026, 17,6438-6447
DOI: 10.1039/D5SC08224B, Edge Article

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Guoqiang Cheng, Bo Yang, Feng Zhu
The first stereoretentive reversed acyl C-glycosylation of nonclassical anomeric nucleophiles provides efficient access to both D- and L-reversed C-acyl glycosides.
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Catalytic relevance of a quinol anion in biological energy conversion by respiratory complex I

Chem. Sci., 2026, 17,6688-6701
DOI: 10.1039/D5SC07500A, Edge Article

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Oleksii Zdorevskyi, Johannes Laukkanen, Vivek Sharma
Quinol anion in respiratory complex I.
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From two to one: resolving CO binding in acetyl-CoA synthase

Chem. Sci., 2026, 17,6755-6765
DOI: 10.1039/D5SC08875E, Edge Article

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Denise Poire, Cornelius C. M. Bernitzky, Mathesh Vaithiyanathan, Berta M. Martins, Christian Lorent, Tamanna M. Ahamad, Vladimir Pelmenschikov, Igor Sazanovich, Gregory M. Greetham, Ingo Zebger, Holger Dobbek, Maria Andrea Mroginski, Marius Horch
Acetyl-CoA synthase is a key enzyme in biological carbon fixation. Combining ultrafast and two-dimensional infrared spectroscopy with anharmonic frequency calculations, we demonstrate that the enzyme binds a single CO ligand under native conditions.
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Alkaline-adaptive covalent organic framework photocatalysts: synergistic molecular orbital and hydrogen-bond network engineering for H2O2 production

Chem. Sci., 2026, 17,6456-6466
DOI: 10.1039/D5SC08298F, Edge Article

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Zhiwu Yu, Jiayi Zhang, Xiaolong Zhang, Xuwen Sun, Guihong Wu, Zhiyun Zhang, Fengtao Yu, Jianli Hua
A phenazine-based COF was engineered via molecular-orbital modulation and hydrogen-bond network construction, improving charge separation/transfer and OH⁻ adsorption for efficient alkaline H₂O₂ production via the cooperative 2e⁻ ORR/4e⁻ WOR.
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A mechanochemical route to triazatrinaphthylenes: building blocks for π-extended, nitrogen-enriched two-dimensional metal–organic frameworks

Chem. Sci., 2026, 17,6467-6476
DOI: 10.1039/D5SC08373G, Edge Article

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Rohan Mahapatra, Kalipada Koner, Ranajit Maity, Rahul Banerjee
Mechanochemical synthesis of C_3h-symmetric triazatrinaphthylenes enables direct intermediate observation and yields a hexa-hydroxy ligand forming a crystalline Cu(II)-MOF with 821 m² g⁻¹ surface area.
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Wavelength-resolved heterodimer [2 + 2] photocycloadditions for reversible surface grafting

Chem. Sci., 2026, 17,6402-6410
DOI: 10.1039/D5SC07978K, Edge Article

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Dushani Kanchana, Lauren Geurds, Aaron Micallef, Bryan Tuten, Kai Mundsinger, Christopher Barner-Kowollik
We report the first wavelength-dependent quantum yields of a [2 + 2] photocycloaddition generating the heterodimers of 7-hydroxycoumarin (7HCou) and styrene via a photochemical action plot.
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Reactive lithium fluoride revitalizes bulk-interface Na-ion transport in all-solid-state PEO-based sodium batteries

Chem. Sci., 2026, 17,6619-6631
DOI: 10.1039/D5SC08784H, Edge Article

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You Fan, Binghong Zhao, Xin Zou, Wenlong Zhao, Yanyan Zhang, Meizhen Zhu, Hong Zhang, Zige Hong, Xin Cheng, Peiming Chen, Zhengshuai Bai, Yanbin Shen, Yuxin Tang
A reactive lithium fluoride-mediated strategy with in situ formed supramolecular compounds is presented for the revitalization of bulk-interface Na⁺ transport in all-solid-state PEO-based sodium batteries.
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Time-ordered-expression mRNA (TOE mRNA) for melanoma RNA vaccines

Chem. Sci., 2026, 17,6605-6618
DOI: 10.1039/D5SC07482G, Edge Article

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Xiangdong Zhang, Xucong Teng, Yicong Dai, Ningqiang Gong, Qiushuang Zhang, Difei Hu, Yuncong Wu, Hongwei Hou, Jinghong Li
We developed a TOE mRNA system via A-to-I base editing, enabling immediate antigen translation and ∼12 h delayed adjuvant translation. This strategy may advance next-generation mRNA vaccines with robust anti-tumor response and improved efficacy.
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[1H]/[2H] discriminated bianthryl atropisotopomers: enantiospecific syntheses from BINOL and direct multi-spectroscopic analyses of their isotopic chirality

Chem. Sci., 2026, 17,6513-6523
DOI: 10.1039/D5SC09200K, Edge Article

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Florian Rigoulet, Guillaume Dauvergne, Jean-Valère Naubron, Philippe Lesot, Christie Aroulanda, Yoann Coquerel
Solid-state VCD and chiral anisotropic ²H NMR spectroscopies are successfully used in the analysis of highly enantioenriched isotopically chiral atropisomers derived from enantiopure BINOL.
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Diketo[n]CPPs as chiral and shape-adaptive fullerene hosts and precursors to DBP[n]CPPs

Chem. Sci., 2026, 17,6677-6687
DOI: 10.1039/D5SC05305F, Edge Article

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Xiaoshuang Xiang, Mathias Hermann, Lei Ye, Philipp Seitz, Lilian Estaque, Grégory Pieters, Thomas Drewello, Birgit Esser
Diketo[8]CPP and diketo[9]CPP are chiral conjugated nanohoops with high photoluminescence quantum yields and shape-adaptive fullerene binding.
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Deep profiling reveals coordinated remodeling of ganglioside metabolism in MCF-7 breast cancer cell line

Chem. Sci., 2026, 17,6488-6499
DOI: 10.1039/D5SC09445C, Edge Article

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Yichun Wang, Gaoge Sun, Hang Yin, Yu Xia
This study develops a deep profiling workflow that reveals coordinated remodeling of gangliosides at multiple structural levels in breast cancer cells for the first time.
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Planar hexacoordinate chlorine

Chem. Sci., 2026, 17,6411-6418
DOI: 10.1039/D5SC09167E, Edge Article

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Ya-Xuan Cheng, Li-Xia Bai, Fernando Martínez-Villarino, Jin-Chang Guo, Gabriel Merino
This study reports Cl©Zn₆O₆⁻ as a planar hexacoordinate chlorine global minimum and superhalogen anion, stabilized by multicenter ionic interactions within a rigid Zn₆O₆ ligand framework.
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B ← N Lewis pair fusion of [6]helicene: one way to integrate circularly polarized luminescence with two-photon absorption

Chem. Sci., 2026, 17,6426-6437
DOI: 10.1039/D5SC08697C, Edge Article

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Min Wang, Zhi-Qiang Liu, Cui-Hua Zhao
Electron-donor substituted B ← N-fused [6]helicenes display both circularly polarized luminescence (CPL) and two-photon absorption (TPA), which are enhanced by polar-to-quadrupolar structural evolution.
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A carbon nanotube-modified electrode for a highly active and reversible Sn4+/Sn anode

Chem. Sci., 2026, 17,6448-6455
DOI: 10.1039/D5SC08606J, Edge Article

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Yue Ao, Yonggang Wang, Shuo Wang, Chengji Zhao, Congxin Xie, Xianfeng Li
In situ-grown CNTs decorated on carbon felts overcome reversibility issues of Sn⁴⁺/Sn couple, enabling a Sn/Br flow battery with 80% energy efficiency at 40 mA cm⁻², 650 h stability, 373 Ah L⁻¹ discharge capacity and 614 mAh cm⁻² areal capacity.
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Beyond wingtips: backbone alkylation affects the orientation of N-heterocyclic carbenes on gold nanoparticles

Chem. Sci., 2026, 17,6717-6726
DOI: 10.1039/D5SC05986K, Edge Article

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Ahmadreza Nezamzadeh, Shayanta Chowdhury, Gaohe Hu, Nathaniel L. Dominique, Emmett Desroche, Sakiat Hossain, Mark D. Aloisio, Michael Furlan, Ryan R. K. Groome, Kayla Boire, Alastair B. McLean, Lasse Jensen, Jon P. Camden, Cathleen M. Crudden
In addition to the strong effect of wingtip structure, the type and number of backbone groups on N-heterocyclic carbenes (NHCs) is shown to have a significant effect on the orientation of NHCs on gold nanoparticles and flat Au(111) surfaces.
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Precise graphitic nitrogen-incorporation by electrochemical oxidation

Chem. Sci., 2026, 17,6576-6585
DOI: 10.1039/D5SC08053C, Edge Article

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Leilei Xu, Zhibo Zhang, Hong Zhou, Ziqi Wen, Yuxuan Liu, Heng Dong, Wei Xie
Graphitic nitrogen (graphitic-N) plays a very important role in energy conversion and environmental protection.
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Alkali Metal Cation Effects for Rapid C–H Activation by Iron(0) Complexes

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01470D, Edge Article

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Nereida Hidalgo, Kendal W. Southwell, Ryan Donnelly, Brandon Q. Mercado, Sebastian M Krajewski, Xiaoping Wang, Patrick L. Holland
Ion pairing with alkali metal cations offers a novel way to enhance the rate of C–H activation. This strategy is demonstrated here using diketiminate-supported iron(0) complexes, which previously were shown...
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Solvent–Temperature Coupled Hydride Transfer Controls Product Selectivity in the HSiR₃/KOtBu Catalytic System

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00107F, Edge Article

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Guo-Hui Li, Dong Hui Zhang, Ye Liu, Haojiang Yao, Zhenhao Zhou
The HSiR₃/KO^tBu catalytic system affords a notable regioselective C-H silylation reaction using alkaline earth metals, yet its mechanistic origins and the temperature-dependent selectivity inversion remain unresolved. Here, we combine active...
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Dimerisation of aryl-substituted bicyclobutanes (BCBs): Revealing a new mode of 1,3-dipolar background reactivity

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01258B, Edge Article

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Daniel B. Werz, Malini George, Daniil A. Knyazev, Kamil Świątek, Heinrich von Köller
We present a detailed investigation of dimerisation reactions involving bicyclo[1.1.0]butanes (BCBs), catalysed or mediated by Lewis or Brønsted acids. The study is supported by optimisation experiments for distinct dimers and...
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Photocrosslinking chemistry for direct photopatterning of colloidal nanocrystals: Toward pixelated light emitting diodes and beyond

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC10169G, Review Article

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Wenyue Qing, Hao Zhang
Colloidal quantum dots (QDs) exhibit outstanding optoelectronic properties and solution processability, making them promising candidates for devices such as quantum dot light emitting diodes (QLEDs). The realization of integrated QD‑based...
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Electronic structure manipulation in electrocatalysis: mechanisms and design principles

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC08985A, Review Article

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Hangkai Shi, Yuanduo Li, Shuyi Pang, Aixin Ma, Jianping Lai, Lei Wang
This review addresses four critical electronic-level challenges in electrocatalysis. It examines design strategies. Advanced theoretical methods are highlighted.
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Correction: A theoretical framework to understand high electron mobilities in cable bacteria

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC90073A, Correction

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Andrew J. Smith, David N. Beratan
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From alkynes to spiroindole δ-lactams via a copper-nitrenoid intermediate featuring unusual 1,1-addition and high Z-selectivity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09742H, Edge Article

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Zhiqiang Ren, Tianhui Feng, Yeyao Li, Mengyi Chu, Ye Zheng, Tianli Gao, Bo Han, Ruili Guo, Haojie Ma, Ji-Jiang Wang, Yuqi Zhang
NHC-copper-catalyzed strategy has been developed for the synthesis of spiroindole δ-lactams from dioxazolones and alkyne derivatives. The methodology offers high atom economy, excellent yields, broad functional group tolerance, and Z-selectivity.
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Decoding the tactics for coacervate pedestrian crossing the phospholipid membrane

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00655H, Review Article

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Huimin Yang, Minghao Wei, Yan Qiao
We summarize mechanisms of coacervates crossing phospholipid membranes including vesicular engulfment via electrostatic interaction, photoswitchable phospholipids, caveolin and actin polymerization, and direct penetration via lipid rafts and defects.
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Mixed-valence Ru nanoparticles anchored on N-rich metal-phthalocyanine/graphene vdW heterostructures for hydrogen-bond-assisted alkaline hydrogen evolution

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00386A, Edge Article

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Zichong Xiang, Guanping Wei, Aifeng Yang, Shangyu Li, Sitian Xu, Yuelong Zhou, Longbin Li, Yiwang Chen
Ru@NiFe PPc was developed by anchoring Ru nanoparticles on 2D metal-phthalocyanine/graphene vdW heterostructure for HER. The mixed-valence Ru facilitates H desorption, suppresses OH poisoning, synergistically promotes H₂O adsorption/dissociation.
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Spatially directed charge transfer in a polymer framework for efficient photocatalytic overall water splitting

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00631K, Edge Article

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Xin-Yu Meng, Jin-Jin Li, Peng Liu, Tingwei Wang, Ming Pan, Chih-Chun Ching, Yu-Long Men, Xizhong Chen, Yin-Ning Zhou, Yun-Xiang Pan
A porous polymer framework rich in atomically oxygen and nitrogen sites acts as charge-steering relays to enhance spatially directed charge transfer, leading to a photocatalytic overall water splitting efficiency 50-fold higher than benchmarks.
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Time-resolved tracking of hot carrier relaxation in two types of MBenes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC06945A, Edge Article

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Jie Zhao, Qi Zhang, Pan Xiong, Chunli Wang, Liangzhu Zhang, Jiebo Li, Kun Zhao, Ruifeng Lu, Kaijun Yuan, Xueming Yang
Transient absorption experiments were performed on two types of MBenes, revealing that hot carriers in MoB without termination have a longer lifetime than in terminated Mo_4/3B_2−xT_z due to reduced interaction with phonons.
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A thermochromic polyoxovanadate with a 200 000-fold conductivity gain for boosting zinc-ion battery performance

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01000H, Edge Article

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Ze-Xun Zhang, Xiao-Yue Zhang, Ping-Wei Cai, Shou-Tian Zheng, Cai Sun
The performance of zinc-ion batteries is hampered by the cathode's limited Zn²⁺ intercalation capacity and sluggish kinetics.
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Crosslinker nanocarrier-based intratumoral delivery for protein complex mapping in mitochondria of live tumor-bearing mice

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00098C, Edge Article

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Yuwan Chen, Wenxin Fu, Baofu Ma, Xinwei Li, Wen Zhou, Zhen Liang, Kaiguang Yang, Lihua Zhang, Yukui Zhang
Nanocarrier delivery of crosslinkers into the mitochondria of tumor cells for large-scale protein conformation and interaction mapping in live mice.
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A platform to design and optimise fluorogenic scFvs for detection of interleukin 33

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09634K, Edge Article

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Abigail E. Reese, Utsa Karmakar, Margherita Restori, Marcela A. Hermoso, George M. Church, Erkin Kuru, Marc Vendrell
We developed a chemical platform combining protein labelling and fluorophore identification to accelerate the optimisation of fluorogenic scFvs.
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A general and scalable DNA nano-chip with a fully localized architecture enables biocomputing in living cells and precisely induces cell apoptosis

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01897A, Edge Article

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Jintao Yi, Tingting Chen, Jinghong Li
General and scalable nano-chips with fully localized architectures were constructed by reconfiguring basic logic gates into integrated circuits.
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Electrochemically cooperative halogen-cation delivery enables modular electrophilic haloesterification of both activated and unactivated alkenes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00279J, Edge Article

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He-Huan Xu, Duo-Duo Qian, Yi Fan, Jia-Jia Zhang, Chang-Le Guo, Hai-Chao Xu
Modular chemo-, regio-, and diastereoselective electrophilic haloesterification of both activated and unactivated alkenes was achieved through an electrochemically cooperative halogen-cation delivery strategy.
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Quantum Coherence Enhancement Through Control of Metal-Ligand Covalency: Modulating Spin-Orbit coupling in Isostructural Molecular Qubits

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC09844K, Edge Article

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Subrata Ghosh, Paul Oyala, Maksym Fizer, Vsevolod D. Dergachev, Sergey A. Varganov, Natia Frank
Manipulation of quantum systems for sensing and transduction rely on controlling the interactions between a quantum system and the many degrees of freedom of the bath. In molecular spin quantum...
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Enzymatic oxygen reduction dominates overpotential-driven thermogenesis in mitochondria

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC06693J, Edge Article

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Nuning Anugrah Putri Junji Namari, Mo Yan, Junji Nakamura, Kotaro Takeyasu
Understanding how chemical energy dissipates as heat in non-equilibrium redox systems is a fundamental problem in physical chemistry. While this phenomenon is well described in electrochemical systems such as fuel...
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Nickel-catalyzed hydroxymethylation with α-silicon N-methoxyphthalimides via radical Brook rearrangement

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00986G, Edge Article

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Xiao-Bo Liu, Muhammad Bilal, Jiaying Zuo, Ya-Xin Yu, Yu-Juan Wu, Boming Shen, Peng-Hui Shen, Hua-Jian Xu, Yu-Feng Liang
Nickel-catalyzed reductive hydroxymethylation of aryl electrophiles with α-silicon N-methoxyphthalimides via a radical Brook rearrangement enables late-stage, functional-group-tolerant installation of hydroxymethyl groups.
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A (poly)Pro tip for preserving native disulfide connectivity during thiol-maleimide bioconjugation of disulfide-rich peptides

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC08821F, Edge Article

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Lylia Azzoug, Ana Novak, Hervé Meudal, Jean-Baptiste Madinier, Stéphane Charpentier, Karine Loth, Séverine Morisset-Lopez, Carlo Pifferi, Vincent Aucagne
Generation of specific antibodies against peptides by immunization requires their covalent conjugation to protein carriers to override their inherently weak immunogenicity. The vast majority of bioconjugation approaches to achieve peptide-protein...
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Spin Effect Regulation as A Design Principle for M-N-C Catalysts for Oxygen Electrocatalysis

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00439C, Edge Article

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Haiyan Li, Zhanzhao Fu, Yuan Yuan, Di Zhang, Yubo Chen, Hao Li, Ang Cao
Recent advances indicate that regulating the spin state of metal centers can markedly modulate catalytic performance, motivating interest in exploiting spin effects for the design of highly efficient oxygen electrocatalysts....
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Unlocking azobenzene isomerization mechanisms via an LLM agent-driven workflow integrating simulation, experiment, and machine learning

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC08794E, Edge Article

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Yixi Shen, Ledu Wang, Yan Huang, Xiaolong Zhang, Meng Huang, Huirong Li, Jing He, Aoran Cai, Yang Wang, Pieter E. S. Smith, Jun Jiang, Zhuoying Zhu, Linjiang Chen
LLM agent orchestration links theoretical simulation, robotic spectroscopy, and interpretable machine learning to predict azobenzene isomerization state from spectra, achieving transferability across conditions and scalable mechanistic insight.
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Porous organic polymers based on carbon–carbon coupling reaction: synthesis and applications

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01090C, Review Article

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Yifan Li, Jingyuan Zhao, Dongtao Liu, Guangshan Zhu
This review systematically summarizes various methods for constructing porous organic polymers (POPs) via carbon–carbon coupling reactions, and elaborates on their application scenarios and core advantages in diverse fields.
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An experimental perspective on symmetry breaking and the singlet fission mechanism in solid-state materials

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC08452K, Perspective

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Xinyue Xu, Christopher R. Hall, Trevor A. Smith
Singlet fission (SF) materials are attracting great attention in the field of solar energy research, promising increased light-to-electricity conversion efficiency. Unravelling the mechanisms of SF is crucial to advance this endeavour.
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Water self-dissociation in slit pores displays non-monotonic behavior as a function of water filling

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC07909H, Edge Article

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Sergi Ruiz-Barragan, Daniel Muñoz-Santiburcio, Saskia Körning, Dominik Marx
Currently, there is no consensus on how confinement affects water self-dissociation—whether it is enhanced or suppressed. Using water–graphene slit pores, we show the dissociation barrier to depend non-monotonically on confinement and water filling.
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Atomic-Level Engineering of Single-Atom Catalysts for Selective C-C Coupling in CO2 Hydrogenation to Ethanol

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01691J, Review Article

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Wenyu Zhen, Yiming Liu, Xiaohai Zhang, Shengjie Bai, Aobing Li, Kelun Jiang, Feng Wang, Ya Liu, Yubin Chen, Shaohua Shen
The selective hydrogenation of CO2 to ethanol represents a pivotal route for sustainable carbon utilization and renewable fuel production, yet its efficiency is fundamentally constrained by the C–C coupling step,...
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Ultrasmooth and Thin Pheomelanin-like Film as a Metal-Free Electrocatalytic Enhancer

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00776G, Edge Article

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Chan Yeon Kim, Jae Ryeol Jeong, Seong Ah Jo, Jun Seok Park, Joowon choi, Myung Jun Kim, Minho Kim, Kyungtae Kang, Min Hyung Lee
This study explores a bioinspired approach to enhance electrocatalytic oxygen evolution reaction (OER) performance by employing a pheomelanin-like thin film. Inspired by the complex chemistry of natural pigments, we developed...
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Change of the aromatic nature through face-to-face stacking

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC10179D, Edge Article

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Qian Wang, Rinat Nasibullin, Dage Sundholm
We have computationally studied the aromatic nature of molecules built from tetraoxa-isophlorin (TOI) and Ni(II)-norcorrole (NiNc) moieties. Calculations of the magnetically induced current density (MICD) susceptibility and magnetically induced ring...
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Recent Advances of MOF-based single-atom photocatalysts for CO2 to solar fuels conversion under sunlight irradiation

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00691D, Review Article

Open Access

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Adnan Majeed, Minh-Khoa Duong, Van-Duc Nguyen, Trong-On Do
Solar-driven photocatalytic CO2 conversion offers a sustainable route to address energy demand and carbon emissions. Metal-organic frameworks (MOFs) have emerged as promising photocatalyst platforms due to their tunable structures and...
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Constrained shadow tomography for molecular simulation on quantum devices

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09162D, Edge Article

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Irma Avdic, Yuchen Wang, Michael Rose, Lillian I. Payne Torres, Anna O. Schouten, Kevin J. Sung, David A. Mazziotti
Quantum state tomography is a fundamental task in quantum information science, enabling detailed characterization of correlations, entanglement, and electronic structure in quantum systems.
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Asymmetric Hydrogenation of 3H-Azepines via Catalytic Kinetic Resolution: Access to anti-Disubstituted Azepanes

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01819J, Edge Article

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Linda Bui, Dilara Berna Yildiz, Diego García Matesanz, Esteban Matador, Raquel Sanchez, Iuliana Atodiresei, Giovanni Lonardi, Daniele Leonori
Azepanes are increasingly valued scaffolds in drug discovery, yet general asymmetric methods for their synthesis remain elusive. This limitation is particularly evident for polysubstituted derivatives bearing stereocenters remote from the...
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Geometric Orthogonality as a Recipe for Efficient Intramolecular Charge Generation in Core Substituted NDI Derivatives

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00456C, Edge Article

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Hugh C. Britton, Alberto Martin Santa Daria, Chao Lyu, Andras B. Augusztin, Lewis Cowen, Dejan-Kresimir Bucar, Alethea B Tabor, Bob C. Schroeder, Sandra Gómez, Jose Marin Marin-Beloqui
One of the primary drawbacks of organic materials, compared to their inorganic counterparts in various optoelectronic applications, is their lower charge generation efficiency, which stems from their inherently higher exciton...
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Light-emitting polymer semiconductors in flexible electronics: strategies, challenges and future perspective

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00449K, Perspective

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Xiang An, Wenyu Chen, Zhiyang Sun, Hong Ren, Xiao Luan, Shigang He, Man Xu, Jinyi Lin, Wei Huang
This perspective article reviews strategies—intrinsic flexibility engineering, external plasticization, and elastomer blending—to overcome the stretchability-optoelectronic trade-off in light-emitting polymer semiconductors.
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Phosphine-catalyzed β-C(sp3)–H functionalization of cyclic amines via a halogen based frustrated radical pairs approach

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00591H, Edge Article

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Yukun Xie, Xiaodan Meng, Chenrui Liu, Jiaming Tan, Xiaoxiang Zhang, Zhuan Zhang, Shicheng Dong, Taoyuan Liang
A metal-free, phosphine-catalyzed strategy for the β-position C(sp³)–H functionalization of cyclic amines, enabled by a novel frustrated radical pairs (FRPs) mechanism has been developed.
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Tris((4-BMes2)phenyl)methanide: a carbanion with a delocalised triple quinoidal structure

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC10121B, Edge Article

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Yufeng Zhang, Johannes Krebs, Alexandra Friedrich, Shigehiro Yamaguchi, Ivo Krummenacher, Holger Braunschweig, Todd B. Marder, Lei Ji
Incorporation of strongly accepting BMes₂ (Mes = 2,4,6-trimethylphenyl) groups at the para-positions of a trigonal [CPh₃]⁻ framework leads to extensive delocalisation of the negative charge over the three aryl branches and onto the boron centres.
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A Brønsted acid–base approach for the net monoselective C–F substitution of (trifluoromethyl)alkanes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01042C, Edge Article

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Nicholas J. Coradi, Jeffrey S. Bandar
We disclose a method for the net coupling of nucleophiles with a single fluorine of unactivated (trifluoromethyl)alkanes.
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Dock & Design: Engineering specificity for alternative pimaradiene outcome with the ent-kaurene synthase from Bradyrhizobium japonicum

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC09199C, Edge Article

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Mark Schmidt-Dannert, Yue Zhang, Liang Jin, Qiang Wang, Samuel Tufts, Meirong Jia, Dean J Tantillo, Justin B Siegel, Reuben J. Peters
The complexity of the reactions catalyzed by terpene synthases has hindered enzymatic engineering. In most cases such efforts result in non-specific product outcome, with the targeted compound being produced alongside...
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Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01693F, Edge Article

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Maria Cristina Misuraca, Christopher A. Hunter
When a phosphoryl oxygen interacts with two H-bond donors, the strength of the second H-bonding interaction much weaker than the first interaction, due to electrostatic repulsion between the two donors.
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