RSC - Chem. Sci. latest articles

Hacking a Brønsted Photoacid to Capture and Directly Release a Lewis Acid: Applied to CO2 Photorelease

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02183B, Edge Article

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Berk Delibas, Sumit Sahu, Dani Cotton, Hayden Harkins, Andrew S. Petit, Joaquin Rodriguez-Lopez, Jahan M. Dawlaty
Controlling reactivity using light remains an important goal in chemistry. Since acid-base reactions are central to nearly all chemical phenomena, photoacids are important molecules for controlling reactivity. Conventional photoacids release...
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Evidence of static quenching in the photoredox activity of perylene diimide radical anion: Implications for consecutive photoinduced electron transfer photocatalysis †

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02462A, Edge Article

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Estefanía Sucre-Rosales, Daniel H. Cruz Neto, Eric Vauthey
The radical anions of perylene diimides (PDI^•-* ) are increasingly used photocatalysts in consecutive photoinduced electron transfer (conPET) for aryl-halide reduction. Despite this, the mechanism behind this reduction by...
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Enhanced interfacial charge transport motivated by Bi2Te3–SbPO4@NC heterointerface for superior Zn2+ and NH4+ storage system

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02844F, Edge Article

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Zhiyuan Zha, Ruinan Chen, Tong Zhou, Daohong Zhang, Qiufan Wang
A heterostructured Bi₂Te₃–SbPO₄ composite anchored on nitrogen-doped carbon frameworks (Bi₂Te₃–SbPO₄@NC) is designed, which exhibits excellent Zn²⁺ and NH⁴⁺ storage ability.
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Advances in Lanthanide Probes for Selective Anion Recognition and Sensing in Water

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00878J, Review Article

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Christy Siu, Stephen Jonathan Butler
Selective anion recognition in aqueous media is an important focus in supramolecular chemistry, driven by both the intrinsic challenges of binding anions in highly competitive environments and the significant potential...
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Molten-Salt Flash Synthesis of P-Doped Iron Oxide with Engineered Oxygen Vacancies for Lattice-Oxygen Water Oxidation

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02442D, Edge Article

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Jiahui Luo, Baoxin Wu, Kejun Yan, Yongbiao Mu, Qing Zhang, Huanxiu Zou, Zhiqing Tang, Guobin Zhang, Wanwisa Limphirat, Wenjia Li, Lin Zeng
Industrial anion exchange membrane water electrolysis (AEMWE) still lacks earth-abundant oxygen evolution reaction (OER) catalysts that simultaneously exhibit high intrinsic activity and long-term durability. This limitation mainly originates from the...
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Boron Buckminsterfullerene

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02674E, Edge Article

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Hyun Wook Choi, Yang-Yang Zhang, Deniz Kahraman, Cong-Qiao Xu, Han-Wen Gao, Jun Li, Lai-Sheng Wang
Fullerenes, spherical molecules made entirely of carbon atoms, have played a foundational role in the birth of nanoscience. Despite extensive research, however, comparable structures composed of other elements have remained...
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A One-Electron Perspective on Dative and Ionic Bonding

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01276K, Edge Article

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Daniel Barrena-Espés, Evelio Francisco, Ángel Martín Pendás
The distinction between electron-sharing and dative bonding remains a matter of continued debate more than a century after Lewis’s foundational contributions to chemical bonding. Here we show that part of...
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Zerovalent transition-metal inverse-sandwich complexes of a diborataanthracene dianion

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02501C, Edge Article

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Alexander Gerstner, Merle Arrowsmith, Maximilian Dietz, Cornelius Mihm, Holger Braunschweig
The 9,10-dihydro-9,10-diboraanthracene (9,10-DHDBA) 2,3,6,7,9,10-Me₆-9,10-DHDBA (2) reacted with 1 equiv. [(MeCN)₃Cr(CO)₃] to yield the unsymmetrical half-sandwich complex [(η⁶-2)Cr(CO)₃] (2-Cr), in which the Cr(CO)₃ unit binds exclusively to one DHDBA benzo ring....
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Mechanochemically assembled organometallic complexes: a mechanistic study

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01038E, Edge Article

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Lama Hamdouna, Gianmarco Pisanò, Andrew G. M. Rankin, Julien Trébosc, Laura Falivene, Ida Ritacco, Olivier Devos, Laurent Delevoye, Pascal Roussel, Lucia Caporaso, Luigi Cavallo, Steven P. Nolan, Olivier Lafon, Catherine S. J. Cazin
Solid-state NMR spectroscopy and other techniques are combined to paint a clear picture of distinct mechanisms involved in the mechanochemical synthesis of two organometallic systems.
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TeLLAgent: A Dual-Agent Framework for Reliable Scientific Discovery with Tool-Enhanced LLMs

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC09883A, Edge Article

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Jinyu Sun, Jibin Zhou, Huabei Wang, Wei Liu, Jun Yuan, Yue Wang, Ting Xie, Lin Tan, Hailiang Zhang, Yingping Zou, Zhimin Zhang, Hongmei Lu
Large language model agents hold immense promise for automating scientific discovery, yet their real-world application is hindered by an inability to reliably orchestrate tools and execute complex, multi-step plans without...
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A columnar liquid crystalline self-assembly of a donor–acceptor TADF emitter design for solution-processed OLEDs

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02453J, Edge Article

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Joydip De, Yuka Yasuda, Mikihito Takenaka, Amy Drysdale-Dykes, Hironori Kaji, Eli Zysman-Colman
The self-assembly of π-conjugated molecules into supramolecular columnar structures has become an effective strategy for the creation of soft, durable, and adaptable materials with immense potential for application in organic optoelectronic devices.
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Atomic modulation of Na+ transport channels to enhance rate and cycling performance of tunnel-type sodium manganese oxides

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02363K, Edge Article

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Chen Xu, Qinghua Yi, Kaibin Feng, Jie Lai, Zhihao Lin, Yuanhao Zheng, Xiao Yan, Xi Chen, Chenchen Wang, Zhe Hu
Cu/Ti co-doping modulates the bond length of tunnel-type oxides to optimize the ion pathways and mitigate the Jahn–Teller effect. The synergistic modification effectively boosts rate capability and long-term cycling stability.
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Addressing interfacial chemical corrosion in lithium metal batteries: a ferroelectric-dipole-regulation route

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02846B, Perspective

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Baolei Xu, Zeqiang Xie, Chunxiao Zhang, Liangjun Zhou, Libao Chen, Weifeng Wei
Coupling of chemical corrosion with electrochemical processes aggravates lithium dendrite flooding. Ferroelectric dipole (FD) engineering, especially the use of pre-adsorbed anion-type FDs, enables targeted SEI design to suppress this failure chain.
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Generative intelligence explores the chemical space of ten million catalysts

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01469K, Edge Article

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Ruili Li, Shuoqi Zhang, Qingli Tang, Qingqing Mao, Ritankar Das, Rui Qi, Beien Zhu, Yi Gao
Distributed generative transformers enable large-scale exploration of CH₃-adsorbed catalysts, while dimensionality reduction and MLP screening efficiently map structure–performance relationships for methane conversion.
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Dual-ion Co-storage in a donor–acceptor covalent organic framework for high-performance low-temperature sodium-organic batteries

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02423H, Edge Article

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Xinya Zhang, Shuangqin Yang, Yihao Zhang, Xiaoyan Zhang, Zaiwang Zhao, Yuan Chen
A D–A type COF with a stable conjugated structure is reported for low temperature SIBs. This electrode enables efficient charge transfer, enhances redox kinetics, and exhibits good cycling stability under low-temperature conditions.
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Skeletal rearrangement of [4]helicenes under acidic conditions: dynamic chirality and improved properties by subsequent peripheral editing

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03190K, Edge Article

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Arthur Gaucherand, Romain Duwald, Christelle Herse, Céline Besnard, Gennaro Pescitelli, Jérôme Lacour
Skeletal rearrangement converts 1,13-DMQA into new 1,11- and 3,11-regioisomeric cationic [4]helicenes. Selective peripheral editing tunes optical properties while loss of steric congestion unlocks dynamic chirality and asymmetric induction.
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Unveiling the role of base catalysts in the thiol-Michael addition reaction in liquid crystal oligomers and liquid crystal elastomers

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03222B, Edge Article

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Ramazan Umut Dinc, Johan Lub, Xianwen Lou, Augustinus J. J. Kragt, Albert P. H. J. Schenning
Our studies unveil the role of base catalysts in the thiol-Michael addition reaction in liquid crystal oligomers and liquid crystal elastomers providing a pathway for improving the performance of stimuli-responsive materials and devices.
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Electron transfer from singlet fission dimers: possibilities and limitations

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00259E, Edge Article

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Sree Chithra, Corentin Pigot, Claire Tonnelé, Ashley J. Redman, Sabine Richert, David Casanova, Victor Gray
The singlet/triplet pair equilibrium in tetracene dimers can drive singlet‑like electron transfer but inevitably yields only one long-lived T₁, limiting diffusion-controlled ET efficiencies from free triplets to <100% yield.
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Supramolecular assembly strategy of multinuclear platinum(II) complexes for proof-of-concept detection and extraction of perfluorohexanoic acid

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00989A, Edge Article

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Nicholas Chun-Ming Yeung, Zhen Chen, Ziyong Chen, Eric Ka-Ho Wong, Vivian Wing-Wah Yam
Multinuclear Pt(II) complexes demonstrate intriguing photophysical properties and capabilities to self-assemble into 2D nanosheets. These complexes present an innovative use for proof-of-concept chemosensing of an important substance (PFHxA) in water.
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Advanced functional porous materials for photocatalytic H2O2 production

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01670G, Review Article

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Sagarmani Rasaily, Gourab K. Dam, Sujit K. Ghosh
Advanced functional porous materials (AFPMs), such as COFs, MOFs, POPs, MOPs, HOFs, and their composites, have emerged as efficient photocatalysts for H₂O₂ photo-production. The review highlights recent advances, challenges, and future prospects.
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Fluorinated Carbohydrate-Based Vaccines

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02383E, Perspective

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Elena Chikunova, James Suri, Kathrin Siebold, Ryan Gilmour
The structural virtuosity of carbohydrates forms the basis of a molecular recognition language that is ubiquitous in immunomodulatory processes. This diversity generates the complexity required to accommodate the bandwith of...
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Mechanistic insights into interfacial failure of hard carbon anodes in sodium-ion batteries under extreme conditions

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03211G, Edge Article

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Rongfen Feng, Qiang Wang, Xiaosha Wu, Hanqi Zhang, Yang Gao, Ning Zhao, Jiahe Li, Xiuxia Zhao, Xiaofei Hu
Revealing the failure mechanisms of hard carbon (HC) anodes under extreme temperatures is crucial for the wide-temperature applications of sodium-ion batteries (SIBs). Via electrochemical tests and multi-scale characterizations, we systematically...
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Nano-visualization of Hydrogel Dynamics via Surface Plasmon-Enhanced Aggregation-Induced Emission

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00713A, Edge Article

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Qing-Bo Liang, Zhao Li, Yu-Hua Weng, Lang Chang, Jia-Dai Wang, Ting-Bin Wen, Shuo-Hui Cao, Yao-Qun Li
Understanding conformational transitions in hydrogels is essential for deciphering their stimulus-responsive behavior, yet real-time, label-free monitoring at the nanoscale has remained a fundamental barrier. Here, we introduce surface plasmon coupling...
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Free Energy Simulations on a Biomimetic Glucose Receptor: Understanding the Selectivity of GluHUT

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00738D, Edge Article

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Ryan Eades, Marko Hanzevacki, Adrian John Mulholland, Anthony P. Davis
The bicyclic glucose receptor GluHUT represents a significant advance in supramolecular chemistry, binding glucose in water with an association constant of approximately 18,000 M ^-¹, and showing exceptional selectivity. Elucidating...
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Photocatalysis beyond band gaps and hot carriers: toward a unified view of semiconductor and plasmonic systems

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01450J, Review Article

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Rishi Verma, Gunjan Sharma, Rohit Bansal, Charvi Singhvi, Saideep Singh, Vivek Polshettiwar
Plasmonic and semiconductor photocatalysts for light-driven energy conversion.
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A photochemical strategy for pyrazole to imidazole conversion

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC03470E, Edge Article

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Youhao Wei, Kengo Kasama, Antòn Igartua, Dilara Berna Yildiz, Aurore Ceuninck, Thiago dos Santos, Cornelia Büttner, Damien Thevenet, Martin Bossart, Volker Derdau, Maria Mendez-Perez, Philippe Jubault, Thomas Poisson, Baptiste Roure, Daniele Leonori
Heteroaromatic scaffolds are central to modern medicinal chemistry. Methods that can reconfigure the core heterocycle of a molecule while preserving its substitution pattern would greatly streamline analogue synthesis and bioisosteric...
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Toposelective on-surface synthesis of curved π-extended oligomers based on bowl-shaped aromatics

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01702A, Edge Article

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Marta Gómez-Gómez, Jorge Labella, Jonas Björk, Adriana E. Candia, Tomás Torres, Jorge Lobo-Checa
Toposelective on-surface synthesis of SubPc oligomers on Au(111) is enabled by bowl-down adsorption of ortho-dihalogenated precursors. The halogen substituent controls both the oligomerization outcome and the electronic properties.
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Synergistic energy and charge transfer dynamics in LD/3D perovskite heterojunctions for optoelectronic applications

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC05663B, Perspective

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Bidisha Nath, Pradhi Srivastava, Junjie Xie, Tajamul A. Wani, Karima Al-Hawiti, Xiaohan Jia, Neha Arora, M. Ibrahim Dar
A deeper understanding of the interplay between charge and energy transfer in low-dimensional (LD)/3D perovskite heterojunctions is essential for advancing next-generation perovskite-based optoelectronic technologies.
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Unveiling the role of local temperature gradients in individual zeolites containing metal active sites

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01014H, Edge Article

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Bing Zhao, Zhikang Xu, Guida Li, Gang Meng, Hang Chen, Tong Zhao, Haibo Zhu, Dan Zhao, Mingbin Gao, Mao Ye, Zhongmin Liu
Spatiotemporally-resolved spectroscopy was employed to probe the temperature of active clusters within individual zeolite, while simultaneously monitoring the spatial distribution of active-intermediates and coke species.
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A general strategy for high-efficiency live bacteria imaging and targeted phototherapy

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00548A, Edge Article

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Xinci Wang, Lihao Ding, Jiang Liu, Jiahui Lv, Junjie Liu, Yu Yan, Xutong Li, Huan Shi, Hui Wang, Jiajia Wang, Senquan Liu, Duanhua Cao, Xinxing Yang, Lin Xue
This work incorporates fluorine-substituted benzenesulfonamide groups to construct high-performance peptidoglycan-targeted probes, which achieve wash-free bacterial fluorescence imaging and efficient bacterial inactivation.
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Electronegatively substituted adamantyl units accelerate chemiexcitation of 1,2-dioxetane luminophores while preserving chemical stability

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03261C, Edge Article

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Thomas Leirikh, Noa Naama, Dingxing Wang, Liang Ge, Julian Ihssen, Mario Hupfeld, Phil S. Baran, Doron Shabat
Electronegative lactone-adamantyl groups accelerate 1,2-dioxetane chemiexcitation while preserving stability, converting glow to flash chemiluminescence and boosting bacterial assay signal-to-noise ratios up to 190-fold.
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Stereoselective, borane-catalysed synthesis of syn-β-hydroxyketones from α,β-unsaturated ketones

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03052A, Edge Article

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Julie Macleod, Alastair J. Nimmo, Joseph H. P. Cockcroft, Paula Dominguez-Molano, Gary S. Nichol, Stephen P. Thomas
Boron catalysis and transborylation have enabled the chemo- and stereoselective coupling of enones and aldehydes to give aldol-type products.
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Unmasking the Intrinsic Mechanistic Limits of Manganese Prussian Blue Analogues in Aqueous Zn-Ion Batteries

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02408D, Edge Article

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Sankhadip Saha, Yuan Shang, Ruichen Ma, Xiaoran Zheng, Priyank Vijaya Kumar, Dipan Kundu
Manganese Prussian blue analogues (Mn PBAs) are widely investigated as cathodes for aqueous zinc ion batteries (AZIBs) owing to their open framework and potential two-electron redox, yet their true electrochemical...
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Hierarchical on-surface assembly of nanoribbons through concurrent hydrogen- and chalcogen-bonding interactions

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC08883F, Edge Article

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Antonio Caporale, Luca Persichetti, Gabriele Anselmi, John Lloyd Gildo, Conor Hogan, Deborah Romito, Davide Bonifazi, Luca Camilli
Secondary Bonding Interactions (SBIs), particularly chalcogen bonding interactions (ChBIs), offer powerful opportunities to direct the assembly of functional organic materials on surfaces. Here we combine Te-based ChBIs with F···H hydrogen...
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A machine learning-based workflow for transaminase selection

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00852F, Edge Article

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Alexander J. Rago, Priyanka Raghavan, Lisandra Santiago-Capeles, Ruijie Zhang, Ying Wang, Connor W. Coley
Predictive ML models enable the rank-ordering of transaminase enzymes for a given substrate based on their predicted reactivities, thus expediting enzyme selection for chiral amine synthesis in medicinal chemistry research.
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Spectroscopy-Informed XANES–PXRD Framework for Multi-Property Prediction and Structure Inference

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00651E, Edge Article

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Yang Wang, Siyuan Zhao, Man Luo, Hantao Zeng, Yi Feng, Daobin Liu, Yan Huang, Jun Jiang
Accelerating functional material characterization and rational design faces a fundamental circular bottleneck in which all mainstream computational screening methods rely entirely on a priori crystallographic knowledge, information inherently unavailable for...
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AND-logic MRI contrast by water flux modulation

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01039C, Edge Article

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James P. Smith, Connor M. Ellis, Anna M. Duncan, Jason J. Davis
In this work we demonstrate that relaxivity, and by extension image contrast, can be modulated by an AND-logic polymeric gate at a mesoporous silica interface that is responsive to both low pH and hypoxic microenvironments.
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AgBF4-catalyzed insertion of unactivated alkynes into C–F bonds of acyl fluorides

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02480G, Edge Article

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Tomoya Emmei, Mamoru Tobisu
This study reports an AgBF₄-catalyzed insertion of unactivated alkynes into the C–F bond of acyl fluorides, leading to the formation of valuable fluoroalkene derivatives.
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pH-activatable brominated pentamethine cyanine dyes for imaging-guided photodynamic immunotherapy of tumors

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02842J, Edge Article

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Wangna Tang, Yanbing Cao, Ran Wang, Tian Qiu, Yingqi Hu, Shaoyang Shi, Xiaolong Zeng, Jiangli Fan, Wen Sun, Xiaojun Peng
This pH-activatable C-CyBr dye is photoinert under physiological conditions and turns on fluorescence/PDT in acidic tumors. Corresponding nanoparticles realize imaging-guided therapy to inhibit tumor growth and induce systemic antitumor immunity.
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Multifunctional conductive dressings for wound healing support

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01545J, Review Article

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Jingwen Yang, Lisa I. Pilkington, Jadranka Travas-Sejdic
Advanced multifunctional conductive polymer-based wound dressings integrate biosensing, on-demand drug release and electrical stimulation to enable real-time monitoring of the wound status and adaptive, closed-loop wound management.
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Correction: Controlled intra- and extracellular localization of bioorthogonal polymeric nanozymes

Chem. Sci., 2026, 17,9793-9795
DOI: 10.1039/D6SC90100J, Correction

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Cristina-Maria Hirschbiegel, Mathangi Shrikanth, Yagiz Anil Cicek, Nourina Nasim, Joe Truong, Junwhee Yang, Alexander Ribbe, Maged Abdelaziz, Vincent M. Rotello
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Non-equilibrium preparation of (E)-phosphinimine (HPNH, X1A′) – a precursor to prebiotic phosphorylating agents

Chem. Sci., 2026, 17,9446-9453
DOI: 10.1039/D6SC01818A, Edge Article

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Jia Wang, Bing-Jian Sun, Alexandre Bergantini, Zesen Wang, Mason McAnally, Joshua H. Marks, Agnes H. H. Chang, André K. Eckhardt, Ralf I. Kaiser
This study reports the first formation of (E)-phosphinimine (HPNH, X¹A′) – the simplest iminophosphane – in low-temperature interstellar model ices composed of phosphine (PH₃) and ammonia (NH₃) exposed to galactic cosmic ray proxies.
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Direct visualization of inner-sphere electrocatalytic reactions as they occur at detachable electrochemical interfaces

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01821A, Edge Article

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Xiangbiao Zeng, Peimeng Qiu, Xi Cui, Chengbiao Zhu, Chen Zeng, Jianxiong Chen, Peng Li, Shengli Chen, Zhenwei Wei
A detachable electrochemical interface using [Au₉(PPh₃)₈]³⁺ nanocluster enables real-time MS monitoring of inner-sphere electrocatalysis.
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High energy density quasi-solid-state lithium batteries using in situ polymerized gel electrolytes

Chem. Sci., 2026, 17,9344-9369
DOI: 10.1039/D6SC01543C, Review Article

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Zehui Fan, Yingxin Liu, Lanhua Ma, Hang Liu, Qinghao Chen, Yi Wang, Ewa Zygadło-Monikowska, Yunhua Xu
This review provides an overview of recent progress in high energy density quasi-solid-state lithium batteries using in situ polymerized gel electrolytes. It also discusses the future perspectives and potential avenues for development in this field.
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Electrochemical functionalization of pyridines

Chem. Sci., 2026, 17,9370-9397
DOI: 10.1039/D6SC00233A, Review Article

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Satabdi Bera, Tushar Singha, Nakul Abhay Bapat, Durga Prasad Hari
This review highlights electrochemical strategies for pyridine functionalization that overcome challenges associated with pyridine's low nucleophilicity, regioselectivity, and catalyst poisoning, enabling efficient and selective transformations.
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Engineering porous organic polymers for enhanced CO2 capture: from synthesis to implementation

Chem. Sci., 2026, 17,9407-9445
DOI: 10.1039/D6SC00384B, Review Article

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Mohammed G. Kotp, Shiao-Wei Kuo
The escalating concentration of atmospheric carbon dioxide (CO₂) necessitates the development of efficient and scalable carbon capture technologies.
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Confined nanopores and hydrogen bonds of polyoxometalates for continuous electricity generation from fluctuating humidity

Chem. Sci., 2026, 17,9468-9480
DOI: 10.1039/D6SC00287K, Edge Article

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Tuo Ji, WeiLin Chen, Fan Liao, ZhenHui Kang
A continuous humidity power generation strategy based on polyoxometalates (POMs) with confined nanopores and hydrogen bonds for effectively collecting water molecules and maintaining water adsorption gradient in fluctuating environmental humidity.
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Organic supramolecular assemblage-confined photoluminescence

Chem. Sci., 2026, 17,9398-9406
DOI: 10.1039/D5SC10066F, Review Article

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Hengzhi Zhang, Yu Liu
Macrocyclic and linear supramolecular hosts can bond a variety of organic luminophores to construct luminescent systems with large Stokes shifts with applications in near-infrared targeted imaging, drug detection, photodynamic therapy, etc.
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From alkynes to spiroindole δ-lactams via a copper-nitrenoid intermediate featuring unusual 1,1-addition and high Z-selectivity

Chem. Sci., 2026, 17,9695-9702
DOI: 10.1039/D5SC09742H, Edge Article

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Zhiqiang Ren, Tianhui Feng, Yeyao Li, Mengyi Chu, Ye Zheng, Tianli Gao, Bo Han, Ruili Guo, Haojie Ma, Ji-Jiang Wang, Yuqi Zhang
NHC-copper-catalyzed strategy has been developed for the synthesis of spiroindole δ-lactams from dioxazolones and alkyne derivatives. The methodology offers high atom economy, excellent yields, broad functional group tolerance, and Z-selectivity.
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Nickel-catalyzed hydroxymethylation with α-silicon N-methoxyphthalimides via radical Brook rearrangement

Chem. Sci., 2026, 17,9653-9662
DOI: 10.1039/D6SC00986G, Edge Article

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Xiao-Bo Liu, Muhammad Bilal, Jiaying Zuo, Ya-Xin Yu, Yu-Juan Wu, Boming Shen, Peng-Hui Shen, Hua-Jian Xu, Yu-Feng Liang
Nickel-catalyzed reductive hydroxymethylation of aryl electrophiles with α-silicon N-methoxyphthalimides via a radical Brook rearrangement enables late-stage, functional-group-tolerant installation of hydroxymethyl groups.
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Mixed-valence Ru nanoparticles anchored on N-rich metal-phthalocyanine/graphene vdW heterostructures for hydrogen-bond-assisted alkaline hydrogen evolution

Chem. Sci., 2026, 17,9720-9730
DOI: 10.1039/D6SC00386A, Edge Article

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Zichong Xiang, Guanping Wei, Aifeng Yang, Shangyu Li, Sitian Xu, Yuelong Zhou, Longbin Li, Yiwang Chen
Ru@NiFe PPc was developed by anchoring Ru nanoparticles on 2D metal-phthalocyanine/graphene vdW heterostructure for HER. The mixed-valence Ru facilitates H desorption, suppresses OH poisoning, synergistically promotes H₂O adsorption/dissociation.
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Ultrasmooth and thin pheomelanin-like film as a metal-free electrocatalytic enhancer

Chem. Sci., 2026, 17,9780-9792
DOI: 10.1039/D6SC00776G, Edge Article

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Chan Yeon Kim, Jae Ryeol Jeong, Seong Ah Jo, Jun Seok Park, Joowon Choi, Myung Jun Kim, Minho Kim, Kyungtae Kang, Min Hyung Lee
Ultrasmooth and thin pheomelanin-like films are developed as metal-free electrocatalytic enhancers. These conformal organic coatings significantly improve OER performance on RuO₂ by optimizing interfacial charge-transfer kinetics.
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Change of the aromatic nature through face-to-face stacking

Chem. Sci., 2026, 17,9768-9779
DOI: 10.1039/D5SC10179D, Edge Article

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Qian Wang, Rinat T. Nasibullin, Dage Sundholm
Antiaromatic porphyrinoid rings form stacked aromatic dimers with a delocalized double bond between each pair of the porphyrinoid rings.
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Constrained shadow tomography for molecular simulation on quantum devices

Chem. Sci., 2026, 17,9633-9643
DOI: 10.1039/D5SC09162D, Edge Article

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Irma Avdic, Yuchen Wang, Michael Rose, Lillian I. Payne Torres, Anna O. Schouten, Kevin J. Sung, David A. Mazziotti
Quantum state tomography is a fundamental task in quantum information science, enabling detailed characterization of correlations, entanglement, and electronic structure in quantum systems.
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Large-scale protein conformational transitions revealed by weighted ensemble simulations and EPR

Chem. Sci., 2026, 17,9747-9759
DOI: 10.1039/D5SC08971A, Edge Article

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Shramana Palit, Darian T. Yang, Xiaowei Bogetti, Anthony T. Bogetti, Olivia Wood, Sunil Saxena, Lillian T. Chong
Conformational exchange pathways of LAO binding protein revealed through an integrated EPR spectroscopy and weighted ensemble simulation approach.
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Spatially directed charge transfer in a polymer framework for efficient photocatalytic overall water splitting

Chem. Sci., 2026, 17,9507-9515
DOI: 10.1039/D6SC00631K, Edge Article

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Xin-Yu Meng, Jin-Jin Li, Peng Liu, Tingwei Wang, Ming Pan, Chih-Chun Ching, Yu-Long Men, Xizhong Chen, Yin-Ning Zhou, Yun-Xiang Pan
A porous polymer framework rich in atomically oxygen and nitrogen sites acts as charge-steering relays to enhance spatially directed charge transfer, leading to a photocatalytic overall water splitting efficiency 50-fold higher than benchmarks.
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Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor

Chem. Sci., 2026, 17,9609-9615
DOI: 10.1039/D6SC01693F, Edge Article

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Maria Cristina Misuraca, Christopher A. Hunter
When a phosphoryl oxygen interacts with two H-bond donors, the strength of the second H-bonding interaction much weaker than the first interaction, due to electrostatic repulsion between the two donors.
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Time-resolved tracking of hot carrier relaxation in two types of MBenes

Chem. Sci., 2026, 17,9703-9710
DOI: 10.1039/D5SC06945A, Edge Article

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Jie Zhao, Qi Zhang, Pan Xiong, Chunli Wang, Liangzhu Zhang, Jiebo Li, Kun Zhao, Ruifeng Lu, Kaijun Yuan, Xueming Yang
Transient absorption experiments were performed on two types of MBenes, revealing that hot carriers in MoB without termination have a longer lifetime than in terminated Mo_4/3B_2−xT_z due to reduced interaction with phonons.
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On-complex three-component cascade reactions involving phosphorescent cyclometalated Ir(III) chloro-isocyanide complexes, nitriles, and propylamine

Chem. Sci., 2026, 17,9591-9599
DOI: 10.1039/D6SC00822D, Edge Article

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Son N. T. Phan, Vinh Q. Dang, Thomas S. Teets
Three-component cascade reactions involving bis-cyclometalated iridium isocyanide precursors, propylamine, and an alkyl nitrile furnish imino-acyclic diamino carbene products, further modifiable by deprotonation.
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A thermochromic polyoxovanadate with a 200 000-fold conductivity gain for boosting zinc-ion battery performance

Chem. Sci., 2026, 17,9711-9719
DOI: 10.1039/D6SC01000H, Edge Article

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Ze-Xun Zhang, Xiao-Yue Zhang, Ping-Wei Cai, Shou-Tian Zheng, Cai Sun
The performance of zinc-ion batteries is hampered by the cathode's limited Zn²⁺ intercalation capacity and sluggish kinetics.
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Lan enzyme-free construction of lanthionine-bridged macrocyclic phage libraries

Chem. Sci., 2026, 17,9582-9590
DOI: 10.1039/D6SC01577H, Edge Article

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Fan Yang, Jiaxi Xiao, Weihang Huang, Jianmin Gao
Phage displayed lanthipeptide libraries are constructed for the first time without the need for Lan enzymes.
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Unlocking azobenzene isomerization mechanisms via an LLM agent-driven workflow integrating simulation, experiment, and machine learning

Chem. Sci., 2026, 17,9663-9673
DOI: 10.1039/D5SC08794E, Edge Article

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Yixi Shen, Ledu Wang, Yan Huang, Xiaolong Zhang, Meng Huang, Huirong Li, Jing He, Aoran Cai, Yang Wang, Pieter E. S. Smith, Jun Jiang, Zhuoying Zhu, Linjiang Chen
LLM agent orchestration links theoretical simulation, robotic spectroscopy, and interpretable machine learning to predict azobenzene isomerization state from spectra, achieving transferability across conditions and scalable mechanistic insight.
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Resonator-based add-drop filters enabled by flexible polymorphic crystals with TADF-RTP motifs

Chem. Sci., 2026, 17,9516-9525
DOI: 10.1039/D5SC08545D, Edge Article

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Pradip Pattanayak, Ankur Khapre, Shamim Ahmad, Avulu Vinod Kumar, Bishes Ray, Satendra Kumar, Chilla Malla Reddy, Rajadurai Chandrasekar, Pradipta Purkayastha
We demonstrate the use of yellow and green fluorescence (Y-FL and G-FL) obtained from polymorphic crystals as signals in an add-drop filter (P-ADF).
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Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme

Chem. Sci., 2026, 17,9562-9569
DOI: 10.1039/D6SC00858E, Edge Article

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Jinmeng Yu, Chang Wang, Wenhao Hu, Huan Wang, Jing Zhao, Hui-Jie Pan
Enantioselective electrophilic α-fluorination was achieved using a Sav–biotin-based artificial metalloenzyme with moderate to high yields and enantioselectivities.
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Redox-mediator enhanced electrochemiluminescence under non-aqueous conditions

Chem. Sci., 2026, 17,9481-9491
DOI: 10.1039/D5SC08710D, Edge Article

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Steven J. Blom, Fazeleh Mesgari, El M. S. Martin, Egan H. Doeven, David J. Hayne, Timothy U. Connell, Peter J. Barnard, Narges Saeedizadeh, Seyed Mohammad Jafar Jalali, Paul S. Francis
The ability to examine novel electrochemiluminophores and redox mediators without the need to synthesise water-soluble analogues enables more rapid fundamental development of this chemistry for future applications.
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Crosslinker nanocarrier-based intratumoral delivery for protein complex mapping in mitochondria of live tumor-bearing mice

Chem. Sci., 2026, 17,9731-9738
DOI: 10.1039/D6SC00098C, Edge Article

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Yuwan Chen, Wenxin Fu, Baofu Ma, Xinwei Li, Wen Zhou, Zhen Liang, Kaiguang Yang, Lihua Zhang, Yukui Zhang
Nanocarrier delivery of crosslinkers into the mitochondria of tumor cells for large-scale protein conformation and interaction mapping in live mice.
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A platform to design and optimise fluorogenic scFvs for detection of interleukin 33

Chem. Sci., 2026, 17,9501-9506
DOI: 10.1039/D5SC09634K, Edge Article

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Abigail E. Reese, Utsa Karmakar, Margherita Restori, Marcela A. Hermoso, George M. Church, Erkin Kuru, Marc Vendrell
We developed a chemical platform combining protein labelling and fluorophore identification to accelerate the optimisation of fluorogenic scFvs.
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A general and scalable DNA nano-chip with a fully localized architecture enables biocomputing in living cells and precisely induces cell apoptosis

Chem. Sci., 2026, 17,9674-9683
DOI: 10.1039/D6SC01897A, Edge Article

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Jintao Yi, Tingting Chen, Jinghong Li
General and scalable nano-chips with fully localized architectures were constructed by reconfiguring basic logic gates into integrated circuits.
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Phosphine-catalyzed β-C(sp3)–H functionalization of cyclic amines via a halogen based frustrated radical pairs approach

Chem. Sci., 2026, 17,9616-9624
DOI: 10.1039/D6SC00591H, Edge Article

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Yukun Xie, Xiaodan Meng, Chenrui Liu, Jiaming Tan, Xiaoxiang Zhang, Zhuan Zhang, Shicheng Dong, Taoyuan Liang
A metal-free, phosphine-catalyzed strategy for the β-position C(sp³)–H functionalization of cyclic amines, enabled by a novel frustrated radical pairs (FRPs) mechanism has been developed.
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Tris((4-BMes2)phenyl)methanide: a carbanion with a delocalised triple quinoidal structure

Chem. Sci., 2026, 17,9625-9632
DOI: 10.1039/D5SC10121B, Edge Article

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Yufeng Zhang, Johannes Krebs, Alexandra Friedrich, Shigehiro Yamaguchi, Ivo Krummenacher, Holger Braunschweig, Todd B. Marder, Lei Ji
Incorporation of strongly accepting BMes₂ (Mes = 2,4,6-trimethylphenyl) groups at the para-positions of a trigonal [CPh₃]⁻ framework leads to extensive delocalisation of the negative charge over the three aryl branches and onto the boron centres.
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Tuneable electronic coupling in linked bis(cubane) cobalt-oxo clusters

Chem. Sci., 2026, 17,9760-9767
DOI: 10.1039/D5SC09713D, Edge Article

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Vincent J. P. Maddi, T. Don Tilley
Dimeric complexes of cobalt-oxo cubane clusters relevant to water-oxidation are synthesized and demonstrated to possess inter-cluster electronic coupling via electrochemistry.
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Constructing interfacial charge transfer channels via plasmon-mediated dual excitation in S-vacancy-rich ZnIn2S4/CuSe heterostructures for enhanced NIR-driven H2 production

Chem. Sci., 2026, 17,9492-9500
DOI: 10.1039/D6SC01125J, Edge Article

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Yuanyong Huang, Cai Ning, Xinyu Lu, Yang Chao, Junhao He, Qiankun Gao, Yu Yu, Zhongkai Xie, Hailing Huo, Weidong Shi
We rationally designed a sulfur-vacancy-rich ZnIn₂S₄/plasmonic CuSe heterojunction for efficient and stable NIR-driven photocatalytic H₂ evolution via a plasmon-mediated dual-excitation (PMDE) mechanism.
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A secondary-sphere proton channel accelerating metal–hydride formation in Mn(I) catalysts for selective CO2-to-formate conversion

Chem. Sci., 2026, 17,9535-9551
DOI: 10.1039/D5SC09412G, Edge Article

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Min-Jong Bong, Wonjung Lee, Daehan Lee, Hyunuk Kim, Junhyeok Seo, Ho-Jin Son
A bio-inspired secondary-sphere proton channel facilitates rapid metal-hydride formation, enabling highly selective and efficient visible-light-driven CO₂-to-formate conversion by Mn(I) bipyridyl catalysts.
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Density-dependent sodium-storage mechanisms in hard carbon materials

Chem. Sci., 2026, 17,9570-9581
DOI: 10.1039/D6SC00030D, Edge Article

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Alexis Front, Tapio Ala-Nissilä, Miguel A. Caro
Coupling machine-learning potential with grand-canonical Monte Carlo, we simulated hard carbon from structure generation to electrochemical evaluation (0.7–1.9 g cm⁻³), revealing how porosity governs sodium storage mechanisms and overall performance.
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Synergistic diselenide/guanidine catalyzed dehydrophosphorylation of 2-nitrobenzhydrols to access C-stereogenic phosphinates

Chem. Sci., 2026, 17,9526-9534
DOI: 10.1039/D5SC07228J, Edge Article

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Jin-Yu Gong, Pan-Pan Zhou, Yu-Hao Qiao, Zhi-Chao Qi, Qian-Ming Zuo, Qing-Xia Fang, Shang-Dong Yang
An efficient catalytic system for the dehydrophosphorylation of 2-nitrobenzhydrols with P(O)–H compounds through the synergistic action of diselenide and guanidine catalysts.
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Electrochemically cooperative halogen-cation delivery enables modular electrophilic haloesterification of both activated and unactivated alkenes

Chem. Sci., 2026, 17,9684-9694
DOI: 10.1039/D6SC00279J, Edge Article

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He-Huan Xu, Duo-Duo Qian, Yi Fan, Jia-Jia Zhang, Chang-Le Guo, Hai-Chao Xu
Modular chemo-, regio-, and diastereoselective electrophilic haloesterification of both activated and unactivated alkenes was achieved through an electrochemically cooperative halogen-cation delivery strategy.
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A Brønsted acid–base approach for the net monoselective C–F substitution of (trifluoromethyl)alkanes

Chem. Sci., 2026, 17,9644-9652
DOI: 10.1039/D6SC01042C, Edge Article

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Nicholas J. Coradi, Jeffrey S. Bandar
We disclose a method for the net coupling of nucleophiles with a single fluorine of unactivated (trifluoromethyl)alkanes.
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Computational redesign and directed evolution of a lanthanide-dependent photoredox enzyme for enantioselective diol cleavage

Chem. Sci., 2026, 17,9552-9561
DOI: 10.1039/D5SC08010J, Edge Article

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Florian Leiss-Maier, Joshua Behringer, Ghulam Mustafa, Anna Heider, Rahel Mühlhofer, Andreas S. Klein, Michael Groll, Cathleen Zeymer
A combined approach of AI-guided protein redesign and directed evolution yields enantioselective PhotoLanZymes for cerium-dependent photocatalytic C–C bond cleavage.
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Symmetry-breaking charge separation in perylene diimide trimers: effects of aggregation and solvent polarity

Chem. Sci., 2026, 17,9739-9746
DOI: 10.1039/D5SC09357K, Edge Article

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Lie Tian, Guangliu Ran, Shixuan Zheng, Wenkai Zhang
Symmetry-breaking charge separation (SB-CS) of a perylene diimide trimer occurs even in nonpolar solvent. In toluene, intermolecular aggregation enhances π–π interactions and promotes SB-CS, giving efficiency between that in chloroform and acetone.
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Why and when does lattice oxygen participate in oxygen evolution?

Chem. Sci., 2026, 17,9327-9343
DOI: 10.1039/D6SC00812G, Perspective

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Arun Karmakar, Asha K. Satheesan, Subrata Kundu
A chemistry-based framework explains when lattice oxygen participates in oxygen evolution. Metal valence regulation activates oxygen redox, while lattice flexibility enables reversible oxygen exchange, together governing the emergence of the lattice oxygen mechanism.
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Near-infrared (NIR)-responsive activation of Ru-benziphthalocyanine complexes via singlet–triplet transition

Chem. Sci., 2026, 17,9600-9608
DOI: 10.1039/D5SC09646D, Edge Article

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Orie Takayama, Naoyuki Toriumi, Kenjiro Hanaoka, Masanobu Uchiyama
Photodissociation of Ru(II) π-arene complexes of 6π/18π-electron tautomeric benziphthalocyanine can be controlled by intrinsic aromaticity switching under near-infrared photoirradiation, enabling control of the near-IR photophysical properties.
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Near infrared light regulated crystallization-driven self-assembly: a versatile platform for controlled preparation of uniform π-conjugated functional nanostructures

Chem. Sci., 2026, 17,9454-9467
DOI: 10.1039/D6SC00684A, Edge Article

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Rang Chen, Sen Zhang, Xiaoyu Huang, Guolin Lu, Mitchell A. Winnik, Chun Feng
A near-infrared (NIR) light regulated self-assembly strategy for the controlled preparation of π-conjugated nanofibers with photothermal activity and NIR-II emission.
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Defect engineering within clusters to enhance cluster–support interaction boosts catalytic performance

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00569A, Edge Article

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Jiankang Chen, Yangping Wang, Yu Zhang, Huan Yan, Qinzhen Li, Jinsong Chai, Guiqi Gao, Chunyan Liu, Sha Yang, Manzhou Zhu
This study introduces structural defects into clusters to enhance interactions between clusters and supports. In model hydrogenation reactions, defective Au₄₀ clusters demonstrate a 5-fold catalytic enhancement compared to pristine Au₄₄ clusters.
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Artificial intelligence-assisted phenotyping of drug-resistant bacteria using a monosaccharide-based fluorescent sensor array

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00084C, Edge Article

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Zhuo-Fan Zhang, Wen-Zhen Gui, Yi-Fan Tang, Hui-Qi Gan, Xi-Le Hu, Tony D. James, Shengbing Yang, Qian Liu, Xiao-Peng He
A monosaccharide-based fluorescent sensor array utilizing vibration-induced emission achieves the accurate, machine learning-assisted phenotyping of drug-resistant Pseudomonas aeruginosa.
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Reflection on “Site-specific PEGylation of proteins by a Staudinger-phosphite reaction”: from protein modification to ADCs in the clinic

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC90102F, Commentary

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Karl T. Schuppe, Christian P. R. Hackenberger
In celebration of our 15th anniversary and some of our most popular articles, Christian Hackenberger reflects on the area of site-specific protein bioconjugation, covering developments since a paper in Chemical Science on this topic: https://doi.org/10.1039/C0SC00324G.
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Electrolyte-anion-controlled reactivity of aromatic radical cations

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00891G, Edge Article

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Naoki Shida, Takuma Maekawa, Yuki Yasuno, Su-Gi Chong, Ikuyoshi Tomita, Mahito Atobe, Shinsuke Inagi
Electrolyte anions actively control the fate of aromatic radical cations, switching them between persistence and productive C–C bond formation.
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From molecular to macroscopic: predicting liquid–liquid phase equilibria and small-angle scattering of mixtures of organic liquids from atomistic simulation using Kirkwood–Buff theory

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03294J, Edge Article

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Allison A. Peroutka, G. Brian Stephenson, Michael J. Servis
Macroscopic phase equilibria between liquids define the functionality of many biological and industrial processes, yet they are fundamentally challenging to predict.
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Construction of axial chirality through addressing the meta constraint in Catellani reaction

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01871H, Edge Article

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Jin Ge, Yaopeng Liu, Xi Wu, Zhenghao Li, Jie Zhang, Xiaosha Wang, Shihan Liu, Guolin Cheng
Axially chiral biaryls represent an important class of atropisomers that are prevalent in organic ligands, bioactive molecules, and materials. Despite recent advances in the synthesis of atropisomers via the Catellani...
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Co-templating of polyoxoniobates and silicate/germanate trimer-rings in crystals and inorganic gels

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02933G, Edge Article

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Makenzie T. Nord, Andrew P. Porter, Detcho J. N. Aboa, Robert S. Minning, Karlie Bach, Emily Hiatt, Wesley T. Surta, Lev N. Zakharov, Aaron J. Rossini, May Nyman
Polyoxometalate (POM) supramolecular gels are a growing family of materials, both for understanding fundamental self-assembly and fabricating flexible monolithic materials that retain the function of metal oxides.
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The palladium-catalysed modular annulative synthesis of cyclic sulfonimidamides

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02864K, Edge Article

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Kangtao Zhu, Agamemnon E. Crumpton, Michael C. Willis
A modular one-pot Pd-catalysed method for the synthesis of structurally unique benzo-fused cyclic sulfonimidamides from the combination of ortho-halo benzaldehydes and acyclic sulfonimidamides is reported.
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Conformational landscapes resolved by ion mobility mass spectrometry reveal mechanisms of polyubiquitin-controlled phase separation

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00836D, Edge Article

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Christina Glen Robb, Thuy P Dao, Jakub Ujma, Carlos Castaneda, Rebecca Beveridge
Polyubiquitin chains regulate phase separation of the ubiquitin-binding shuttle protein ubiquilin-2 (UBQLN2) in a manner that depends on the position of the isopeptide linkage and the length of the polyubiquitin...
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Correction: Simple, one-step syntheses of tri- and tetracyclic B,N,S-heterocycles from reactions of a diboracumulene with thiols

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC90101H, Correction

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Christian Markl, Sourav Kar, Lukas Lubczyk, Kai Hammond, Rian D. Dewhurst, Holger Braunschweig
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Fluoride-substituted Li6.4La3Zr1.4Ta0.6O12 with Delocalized Electron-Share Accelerates Li+ Desolvation Kinetics for High-voltage Lithium Metal Batteries

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02973F, Edge Article

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Peng Chen, Bing Ding, Hui Dou, Xiaogang Zhang
Metallic lithium is regarded as the ideal anode for the high-specific-energy battery.However, the Li(solvents) x + formation in the liquid-state lithium metal batteries (LMBs) results in sluggish ion transport kinetics...
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Surface-hydrogenation activity regulation toward robust anti-poisoning of ZrCo-based hydrogen isotope storage materials

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC03342C, Edge Article

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Qianwen Zhou, Yiting Yu, Panpan Zhou, Shunrui Xiao, Jingyu Hu, Xuezhang Xiao, Xingwen Feng, Huaqin Kou, Wenhua Luo, Xiulin Fan, Lixin Chen
The ZrCo alloy is promising for hydrogen isotope storage but suffers from severe CO poisoning due to d-orbital back-donation into CO π* orbitals, leading to strong chemisorption that blocks subsequent hydrogen dissociation.
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Design of a site selective heterochromic bimetallic lanthanide coiled coil with nanometre-scale control

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00813E, Edge Article

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Louise N. Slope, Anokhi Shah, Michael J. Taylor, Valentina Borghesani, Simon G. Caulton, Nikolas J. Brooks, Kate A. Hadley, Georgina Rose, Robert I. Hunter, Hassane E. L. Mkami, Graham M. Smith, Aneika C. Leney, Niklaas J. Buurma, Andrew L. Lovering, Janet E. Lovett, Anna F. A. Peacock
A de novo protein scaffold enables selective binding of two different lanthanide ions at distinct sites with nanometre-scale control. This establishes a programmable platform for spatially defined metalloprotein architectures.
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Golden immunity: gold complexes as emerging triggers of immunogenic cell death

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02555B, Perspective

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Marta Redrado, M. Concepción Gimeno
Gold complexes induce immunogenic cell death by coupling redox stress with immune activation, offering new opportunities to convert “cold” tumours into immune-responsive targets.
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Recent progress on Ni-catalysed alkyl–alkyl cross-coupling enabled by asymmetric hydrofunctionalization of alkenes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00960C, Review Article

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Jiao He, Perla Bharath Kumar, Yulong Li, Qiong Yu, Wei Shu
Nickel-catalysed hydrofunctionalization of alkenes constructs stereogenic centres by C(sp³)–C(sp³) cross-coupling. This review highlights recent advances in recent advances in this area, focusing on strategy development, mechanistic considerations.
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Core-block engineering enables control of ice recrystallisation inhibition in polymer nanoparticles

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02659A, Edge Article

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Panagiotis G. Georgiou, Cigdem Buse Oral, Ho Fung Mack, Hubert Buksa, Chenrui Bao, Csilla György, Steven P. Armes, Matthew I. Gibson
We demonstrate that engineering the core blocks of nanoparticles derived from polymerization-induced self assembly can tune the ice-recrystallisation inhibition activity: a previously unexplored route to modulate this biomimetic function.
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Recycling nickel-rich cathodes toward structural and functional circularity: a perspective

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02626E, Perspective

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Yuhan Huang, Haoyang Xu, Yimin Zeng, Han Xue, Ge Li
A value-retention classification is proposed for Ni-rich cathode recycling: elemental recovery retrieves metal inventory, structural preservation repairs the layered framework, and functional restoration upgrades performance.
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Dynamic pendulum strategy enables both anti-quenching and fast spin flipping for efficient blue multiple-resonance thermally activated delayed fluorescence emitters

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02881K, Edge Article

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Xiangqin Gan, Bitian Chen, Jia-Qi Li, Han Si, Ning Sun, Guoyun Meng, Xian-Kai Chen, Liming Ding, Zheng-Hong Lu, Junqiao Ding
Inspired by the swinging clock, a dynamic pendulum strategy is proposed to achieve anti-quenching and fast spin flipping for efficient blue narrowband EL, delivering a new EQE benchmark of 30.4% at over 20 wt% high doping concentration.
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