RSC - Analyst latest articles

Spatial distribution and structural discrimination of quorum sensing metabolites in Pseudomonas aeruginosa by MALDI-MSI

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00245E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Christel Kuik, Sanne van Hoogstraten, Lisa Mayrginther, Jacobus J. Arts, Maarten Honing, Berta Cillero Pastor
Bacterial biofilms are complex bacterial communities embedded within an extracellular polymeric substance (EPS) that protects the cells and increases survival. Once established on an orthopaedic implant, biofilm can cause difficult-to-treat...
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Sensitive detection of meat spoilage VOCs and visual monitoring of freshness via a UiO-66-NH2@MR nanocomposite-based colorimetric paper sensor

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00553E, Paper

Chengze Song, Qiyang Gu, Jiaqi He, Bingze Li, Sha Liu
A portable colorimetric paper sensor (UNMPS) based on UiO-66-NH₂@MR nanocomposite enables sensitive detection of meat spoilage VOCs with ppb-level LODs and provides a visual platform for real-time freshness monitoring.
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Threshold-Guided Multiplexed PCR-LFA: A Step Toward UTI Pathogen Detection

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00386A, Paper

Dakshita Snud Sharma, Sumit Gandhi, Manish Ranjan, Dharitri Rath
Urinary tract infections (UTIs) represent a major global healthcare burden, as both its detection and management remain challenging. Although culture-based method remains the gold standard for diagnosis, they require 24-48...
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Decoding the molecular mechanisms of sour and salty sensation via Biomimetic Taste-Based Biosensors

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00465B, Critical Review

Numan Muhammad, Jingyi Li, Jingxi Li, Yuqi Chen, Liping Du, Chunsheng Wu
This review examines the molecular processes that govern the perception of sour and salty flavors and their application in biomimetic sensor technologies. In contrast to sweet, bitter, and umami flavors...
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Optical photothermal infrared (O-PTIR) micro-spectroscopic characterisation of breast cancer cell lines: a comparative molecular profile of MCF7, MDA-MB-231, and SKBR3 cells

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00125D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Megha Mehta, Hao Meng, Suzy Eldershaw, Nick Stone
Sub-micron O-PTIR spectroscopy identifies biochemical fingerprints separating luminal MCF7 from aggressive triple-negative MDA-MB-231 and HER2-enriched SKBR3 breast cancer phenotypes, showing distinguishable trends with partial clustering.
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Surface-engineered biochar–Cu-BTC hybrid for ultrasensitive dual detection of uric acid and nitrite

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00615A, Paper

Afef Dhaffouli, Pedro A. Salazar-Carballo, Soledad Carinelli, Alejandro G. Orive, Lívia Flório Sgobbi, Adam Slabon, Bruno V. M. Rodrigues
A green, electroactivated biochar–Cu-BTC hybrid enables ultrasensitive, simultaneous uric acid and nitrite detection with synergistic Cu-redox catalysis.
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Metabolic profiles of MK-3984 (SARM) in zebrafish using ultra high performance liquid chromatography Q extractive HF hybrid quadrupole orbitrap mass spectrometry (UPLC-QE-HF-MS) for doping control

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00421K, Paper

Yang Liu, Zhengyang Guo, Siyang Qin, Xuxiao Zhao, Xiaopei Wu, Jing Jing, Jianghai Lu
In this study, the metabolic profiles of MK-3984, a selective androgen receptor modulator (SARM) targeting muscle and bone tissues, were comprehensively investigated for the first time using quadrupole orbitrap LC-MS/MS in a zebrafish model.
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Opportunities and challenges for analytical chemists: organ-on-chip devices as new approach methods (NAMs) for identifying potential toxins

Analyst, 2026, 151,3628-3641
DOI: 10.1039/D5AN01351H, Perspective

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Evan Huang, Jose A. Nolasco, Sarina J. Jones, Matthew R. Lockett
This perspective outlines and highlights the key features needed to advance organ-on-chip devices as NAMs for assessing the toxicity of new drug candidates and potential toxins.
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AuNPs/rGO-enhanced molecularly imprinted field-effect transistor sensor for highly selective detection of lactic acid in sweat

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00218H, Paper

Yi Xiong, Hong Zhu, Lei Wang, Runan Tan, Ting Wang, Ping Wang, Hanping He, Gang Chang
A label-free MIP/AuNPs/rGO-FET sensor enables highly sensitive and selective detection of lactic acid in sweat. With a 3.33 pM detection limit and excellent stability, it offers a reliable platform for non-invasive health monitoring.
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Rapid antimicrobial susceptibility testing in bloodstream infections: current landscape and emerging technologies

Analyst, 2026, 151,3613-3627
DOI: 10.1039/D6AN00294C, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dory Nicoletti, Royston Goodacre, Srijan Jindal, Douglas B. Kell
Emerging rapid AST platforms for bloodstream infections aim to provide susceptibility results within hours, but sample preparation and organism–antibiotic coverage remain major challenges to routine clinical adoption.
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Urchin-like covalent organic framework microspheres for electrochemical organophosphorus pesticide sensing

Analyst, 2026, 151,3642-3646
DOI: 10.1039/D6AN00539J, Communication

Hongze Yao, Tong Lu, Yu Wu, Fang Duan, Shuanglong Lu, Baochun Guo, Mingliang Du
The electrochemical detection of organophosphates (OPs) using acetylcholinesterase (AChE) immobilized on a glassy carbon electrode (GCE).
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Low-cost bimetallic FeNi alloy nanoparticles loaded on nitrogen-doped carbon nanotubes for electrochemical sensing of copper ions

Analyst, 2026, 151,3869-3874
DOI: 10.1039/D6AN00095A, Paper

Yao Yao, Jun-Chang Xue, Yue Jiang, Heng-Ye Li, Zhong-Xia Wang, Rui Zhang, Fen-Ying Kong, Wei Wang
Inexpensive, highly active, and stable FeNi/N-CNT nanocomposites were used as electrode modifiers for the highly sensitive detection of Cu²⁺.
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A sensitive electrochemical sensor with Hf-MOF@activated Ketjen black/calix[4]arene composite for the detection of 2,2′-methylenebis(4-chlorophenol) in environmental water

Analyst, 2026, 151,3833-3843
DOI: 10.1039/D6AN00351F, Paper

Yu Xie, Jingwen Meng, Zhijie Zhu, Genhe He, Ronghua Hu, Xiuguang Yi, Kalle Salminen
A novel Hf-MOF@activated Ketjen black/calix[4]arenes composite modified electrode sensor was fabricated for the sensitive detection of dichlorophenol in environmental water samples.
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Structure-aware fragment assignment for interpreting tandem mass spectrometry of modified and cyclic peptides

Analyst, 2026, 151,3856-3868
DOI: 10.1039/D6AN00162A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

V. Erckes, A. Misiek, A. Streuli, C. Steuer
Cyclized or chemically modified peptidomimetics challenge MS/MS interpretation because fragmentation extends beyond canonical backbone cleavages or needs multiple bond breaks to yield sequence-informative ions.
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Synergistic peroxidase-like activity of the Cu–Zn MOF-incorporated g-C3N4 nanozyme integrated with a smartphone-based colorimetric sensor for ciprofloxacin detection

Analyst, 2026, 151,3788-3802
DOI: 10.1039/D6AN00320F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Surendhar Sasikumar, Arunjegan Amalraj, Panneerselvam Perumal
Graphical representation of Cu-Zn-MOF/g-C₃N₄ for ciprofloxacin detection.
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Fluorous nanoemulsion optodes with Förster resonance energy transfer-based fluorescence amplification toward highly-sensitive and selective detection of perfluorooctanesulfonate

Analyst, 2026, 151,3647-3654
DOI: 10.1039/D6AN00189K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Soraka Iwamoto, Tatsuro Endo, Hideaki Hisamoto
FRET-based fluorous nanoemulsion optodes enable highly sensitive and selective PFOS⁻ detection down to the 10⁻⁸ M level with a rapid response.
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Charge-tunable hemicyanine probes for bacterial imaging and bacterial infection tracking

Analyst, 2026, 151,3766-3774
DOI: 10.1039/D6AN00336B, Paper

Kunyi Wang, Yiyang Wang, Wenbo Zhu, Lebin Wang, Zixuan Zhang, Boyaxuan Chen, Wenbo Luo, Xuefei Wang, Zhuo Wang
Charge-tunable hemicyanine probes enable selective imaging of Gram-positive and Gram-negative bacteria, real-time tracking of bacterial infection in host cells, and long-term imaging in complex biological fluids.
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Cyclic cataluminescence method enabled by a heterogeneous electron allocator for multiple-aldehyde detection in tea

Analyst, 2026, 151,3755-3765
DOI: 10.1039/D6AN00170J, Paper

Huiting Chen, Mengmeng Ji, Ling Xia, Yufei Hu, Gongke Li
Cyclic chemiluminescence method enabled by a heterogeneous electron allocator for the detection of multiple aldehydes in tea.
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One-step digestion–ligation–activation universal strategy for ultrasensitive detection of DNA methylation

Analyst, 2026, 151,3744-3754
DOI: 10.1039/D5AN01270H, Paper

Shiying Zhou, Tao Gu, Liyuan Deng, Xianfeng Wang, Shuyu Zhu, Xinyu He, Mei Yang, Danqun Huo, Changjun Hou
A digestion–ligation–activation strategy integrates methylation-dependent restriction, RLAMP amplification, and CRISPR/Cas12a trans-cleavage into a one-pot cascade for ultrasensitive DNA methylation and methyltransferase analysis.
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A portable acoustic biosensing platform combined with paper-based capillary fluidics for the rapid detection of antibodies in serum

Analyst, 2026, 151,3733-3743
DOI: 10.1039/D6AN00114A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dimitra Chronaki, Stylianos Grammatikos, Angelos Ntimtsas, Marios Matsis, Orestis F. Kokolakis, Konstantina Alexaki, Zoi Pournara, Achilleas Tsortos, Alexandros Zafiropoulos, Electra Gizeli
We report the development of a sensitive biosensing platform based on a shear-horizontal surface acoustic wave (SH-SAW) device and paper fluidics, with the potential to be used outside centralized laboratory settings.
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A digital microfluidic integrated SiNW array FET for amplification-free detection of extracellular vesicle-derived miRNAs

Analyst, 2026, 151,3666-3676
DOI: 10.1039/D6AN00306K, Paper

Rui Jiang, Jiaqi Guo, Zizhen Wang, Jun Cheng, Han Zhang, Qingzhu Zhang, Lingqian Zhang, Yang Zhao, Chengjun Huang, Mingxiao Li
An integrated DropFET device combining a high-density active-matrix digital microfluidic chip with a silicon nanowire array field-effect transistor sensor enables sample pretreatment and highly sensitive detection of EV–miRNAs.
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Polarization–preservation analysis for robust reflection-mode optical glucose sensing in turbid media

Analyst, 2026, 151,3655-3665
DOI: 10.1039/D6AN00257A, Paper

Hsin-Yi Hsieh, Chia-Chun Chang, Chin-Chuan Hsieh
Circular polarization combined with a PPR metric improves correlation and robustness over linear polarization with DOP in reflection-mode glucose sensing through turbid media.
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An integrated optofluidic platform enabling label-free single-cell sorting and culture

Analyst, 2026, 151,3844-3855
DOI: 10.1039/D6AN00203J, Paper

Baojian Zhang, Fuyuan Chen, Liru Zhao, Mengting Ming, Meina Chen, Chunfang Deng, Yuntong Wang, Huabing Yin, Bei Li, Peng Liang
We present OTMA, an optofluidic platform achieving deterministic, label-free single-cell sorting with >90% viability by decoupling optical trapping from hydrodynamic drag, enabling high-fidelity rare-cell research.
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An IFE-based lysosome-targeted probe for the differential detection and bioimaging of biothiols

Analyst, 2026, 151,3815-3823
DOI: 10.1039/D6AN00211K, Paper

Yuan Xu, Yujia Hou, Tongtong Zhao, Huilin Chen, Hanxi Chai, Zhengrui Zhang, Zhuoyan Cao, Kaixin Xie, Qiaoling Liu
Biothiols (Cys, Hcy, and GSH) are generated by reducing disulfide bonds with the help of proteolysis in lysosomes, and these three biothiols play different roles in preserving the optimal activity of lysosomes.
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Electrochemical determination of nitrofurantoin using a self-templated NiFeCo layered double oxide-carbon composite with dynamic Fe regeneration

Analyst, 2026, 151,3677-3685
DOI: 10.1039/D6AN00347H, Paper

Jiang-Tao Chen, Ming-Dong Wang, Fen-Ying Kong, Tian-Pei Cai, Lu-Mei Wang, Juan-Juan Gao, Wei Wang
A NiFeCo layered double oxide supported N,S co-doped collagen-derived porous carbon (NiFeCo LDO-C) enables trace-level electrochemical detection of nitrofurantoin via dynamic metal active-site regeneration and self-template/self-etching strategy.
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Revealing potassium ion storage in individual Prussian blue nanoparticles with distinct crystallinity via scanning electrochemical cell microscopy

Analyst, 2026, 151,3875-3881
DOI: 10.1039/D6AN00435K, Paper

Mengyao Cao, Yaqi Xiong, Cong Gao, Xinyu Guo, Jia Yin, Mahmoud Elsayed Hafez, Qianjin Chen
Potassium ion storage in individual Prussian Blue nanoparticles with distinct crystallinity was investigated.
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Fix or freeze? Spectral differences arising from tissue preparation in chemical imaging

Analyst, 2026, 151,3721-3732
DOI: 10.1039/D6AN00137H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tianyi Zheng, Wihan Adi, Paul J. Campagnola, Filiz Yesilkoy
Quantum cascade laser (QCL)-based mid-infrared spectrochemical imaging reveals that tissue preparation methods substantially alter the biochemical and morphological information captures from biological tissues, with fresh frozen samples preserving greater native spectral diversity than FFPE tissues.
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Lipidomic signatures of CNS ischemic injury and their modulation by immunomodulatory hydrogels

Analyst, 2026, 151,3686-3699
DOI: 10.1039/D6AN00089D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mary F. Wang, Yunxin Ouyang, Tatiana Segura, David C. Muddiman
Ischemic injury in the central nervous system (CNS) triggers profound metabolic remodeling that influences inflammation, repair, and cellular survival.
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Identification of volatile organic compound markers for bacterial growth in spacecraft wastewater

Analyst, 2026, 151,3775-3787
DOI: 10.1039/D6AN00060F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sarah Kingsley, Hang N. Nguyen, Aaron N. Knopp, Christian L. Castro, Thomas M. Orlando, Sarah L. Castro-Wallace, William T. Wallace
This work presents proof of concept for an MS-based technique for the detection of common spacecraft bacteria in spacecraft wastewater.
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Sulfonic acid-functionalized ordered mesoporous silica as a dispersive solid-phase extraction adsorbent for the determination of 30 organophosphorus pesticides

Analyst, 2026, 151,3700-3712
DOI: 10.1039/D6AN00377J, Paper

Zhimou Chen, Changlong Hao, Hua Kuang, Chuanlai Xu
Sulfonic acid-functionalized ordered mesoporous silica was developed as an efficient DSPE adsorbent for simultaneous determination of 30 organophosphorus pesticides, achieving rapid adsorption and elution with low LODs and good recoveries.
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Ultramicroelectrode fabrication guidelines for multifunctional scanning electrochemical microscopy

Analyst, 2026, 151,3824-3832
DOI: 10.1039/D6AN00234J, Paper

Congshan Guo, Zhizhen Lv, Jigui Tang, Jingshu Hui
Dual-disk electrodes with low RG values and narrow gaps were fabricated reproducibly by combining a thick-wall nanopipette template with tip forging.
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Differentiation of disaccharide isomers via diagnostic-ion-weighted spectral library searching using data from tandem MS analysis of chloride adducts

Analyst, 2026, 151,3803-3814
DOI: 10.1039/D6AN00268D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shixiang Xu, Santosh R. Acharya, Ruth M. Speidel, Abraham K. Badu-Tawiah
Chloride adducts of rare sugars enable diagnostic fragment ions to be generated in tandem MS, allowing a highly specific algorithm to be developed to differentiate isomers of rare sugars.
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A novel electrochemiluminescence sensor using Lu-Au@Ni-MOF for ultra-sensitive detection of permethrin

Analyst, 2026, 151,3713-3720
DOI: 10.1039/D6AN00409A, Paper

Yahui Ji, Nana You, Xiaoping Hu, Fangxin Du, Hui Gao, Jie Ru, Gen Liu
A novel quenching ECL sensor is developed using a Lu-Au@Ni-MOF nanocomposite, which enables the ultrasensitive and selective detection of PT through an efficient signal amplification strategy of Lu-Au@Ni-MOF.
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Single-probe sensor array based on inorganic salts for simple, rapid, and low-cost colorimetric identification of proteins

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00433D, Paper

Changxu Han, Peilu Song, Yue Wang, Hui Ju, Peng Yan
A cost-effective colorimetric sensor array with inorganic salts and AgNPs identifies 17 proteins within 30 minutes via absorbance or smartphone RGB reading.
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Rope-skipping for blood plasma separation in point-of-care testing

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00540C, Paper

Ruoyu Yuan, Xianchang Wu, Tonghuan Zhan, Bing Xu, Xudong Wang
Rope-skipping microfluidic centrifugation (RSMC) achieves 67.3% plasma yield with 99.99% purity in 5 min, 98.3% glucose recovery, and enables simple, electricity-free POCT.
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Tyramide signal amplification integrated with magnetic bead separation to overcome the matrix effect and detect SAA protein in peripheral blood

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00508J, Paper

Hongfan Gao, Juan Wei, Qiong Luo, Xin Li
Complex clinical serum samples often induce severe matrix effects during immunoassay quantification.
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Blue light exposure exacerbates Western diet-induced hepatic lipid accumulation and injury via suppression of the SIRT1–NR1D1 axis

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00267F, Paper

Shu-Jyuan Chang, Wan-Tzu Chen, Yi-Ting Chen, Sebastian Yu, Hsin-Su Yu, Chee-Yin Chai
Blue light exposure suppresses the SIRT1–NR1D1 axis, impairs mitochondrial β-oxidation, and synergizes with a Western diet to promote acylcarnitine accumulation, oxidative stress, and macrophage-driven hepatic inflammation.
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Recent advances in aptasensors for the detection of low molecule pollutants in the environment

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00441E, Minireview

Zhiwei Xu, Rui Zhang, Shi Jia, Liu Xintong, Meng Shi
The pollution caused by low molecular-weight contaminants (molecular weight ＜ 1000 Da) has become an increasingly serious problem worldwide. Such contaminants, including heavy metal ions, pharmaceuticals, pesticides, endocrinedisrupting chemicals (EDCs)...
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Deep Learning-Enabled Microfluidic Digital PCR Platform for Efficient Seven-Color Quantification

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00369A, Paper

Zhenyu Wang, Ke Yang, Jin Zhang, Changyi Hua, Yuanzhi Zhang, Quanfu Wang, Anzhong Hu, Weilong Zhang, Yong Liu, Guoqing Deng, Jun Zhao, Ling Zhu
Digital PCR (dPCR), as a high-sensitivity technology for absolute nucleic acid quantification, holds significant value in biomedical research and environmental monitoring. However, current platforms still face challenges in multiplex fluorescence...
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Analytical Challenges in Mapping the Subcellular Metabolome and Lipidome

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00535G, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Marta Nobile, Simone Serrao, Eleonora Bossi, Francesca Re, Francesca Raimondo, Giuseppe Paglia
Mass spectrometry–based metabolomics and lipidomics are central analytical tools for characterizing cellular chemical composition. However, most workflows still rely on the simplifying assumption of homogeneous intracellular pools, which is increasingly...
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From Silver Nanoparticles to Nanoclusters: Enhanced Oxygen Evolution Electrocatalysis through Size Reduction

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00582A, Paper

Sheetal Sheetal, Usama Ansari, Sanjeeve Thakur, Nancy Gupta
Metal nanoclusters (MNCs) have attracted significant attention as emerging catalytic materials due to their ultrasmall size, discrete electronic states, high surface-to-volume ratio, and abundance of accessible active sites. MNCs are...
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On-Site Rapid Identification of Animal and Plant Cream via 2D FeB Nanozyme-Based Colorimetric Sensor

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00319B, Communication

Jiaheng Jiang, Shihao Su, Jinpei Xu, Yaheng Zhang, Haihui Lan, Wang Zheng, Xin Zhang, Aiguo Zhou, Jingjing Si, Weiwei He
Plant cream with trans fatty acids poses severe health risks, and cholesterol is the core marker to distinguish plant and animal cream. Traditional detection is cumbersome, so we developed a...
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Developing Digital PCR Technologies Based on Wettable Substrates

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00456C, Critical Review

Huimin Wang, Bingli Liu, Feika Bian, Yongxiang Zhao
Since the invention of polymerase chain reaction (PCR) in 1985, the technology has evolved from qualitative PCR to real-time fluorescent quantitative PCR (qPCR) and ultimately to digital PCR (dPCR). Notably,...
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A g-C3N4-stabilized Au nanozyme-based sensor with AI-powered “recognition–extraction–interpretation–report” for bias-minimized in-field monitoring of mercury ions

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00581K, Paper

Qiaoqiao Diao, Linjie Wang, Xinyu Chen, Jinjin Liu, Zheng Tang, Xiangheng Niu
A g-C₃N₄-stabilized Au nanozyme-based sensor with AI-powered “recognition–extraction–interpretation–report” was developed for bias-minimized in-field monitoring of mercury ions.
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Light-activated, highly efficient intracellular biomolecular delivery using a titanium nitride micro-array device

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00474A, Paper

Nandhini Balasubramaniam, Srabani Kar, Amal Kanti Bera, Moeto Nagai, Tuhin Subhra Santra
A titanium nitride micro-array device for light-activated cell therapy uses near-infrared pulsed laser irradiation to induce transient membrane pores, thereby enabling the intracellular delivery of biomolecules.
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Automated offline µ-SPE cleanup in GC-based multi-residue analysis: overcoming the challenges of fatty acid containing matrices

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00462H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ivan Aloisi, Lisa Elsinga, Michel Willemsen, Hans Mol
The aim of this work was to investigate and optimize the use of offline automated µ-SPE cleanup for the analysis of GC-amenable pesticides in fatty acid containing matrices, such as wheat and linseeds.
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A donor–π-acceptor fluorescent probe for hydrogen peroxide monitoring reveals oxidative imbalance and mitochondrial damage caused by Cd/Hg exposure

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00412A, Paper

Jiangkun Tan, Congzheng Zhu, Liangwei Zhang, Yunqing Wang, Xiaoyan Wang, Ping Liu, Li Zhang, Qian Yang, Jinmao You, Lingxin Chen
We developed a high-performance fluorescent probe, TQ-H₂O₂, to visualize H₂O₂ dynamics and reveal how Cd²⁺/Hg²⁺ cause oxidative stress, mitochondrial dysfunction, and cell damage.
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An activatable naphthalimide-based fluorescent probe for hydrogen peroxide detection: visualizing microcystin-LR induced oxidative stress in zebrafish and hepatocyte injury mechanism

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00524A, Paper

Linmin Nie, Ruiqin Zhang, Suyu Liu, Kexin Mu, Tingting Zhao, Xueping Hu, Xingliang Song, Xiaohong Liu, Xueyong Jin, Xiaoyan Wang, Yan Huang, Lingxin Chen
This work developed a highly sensitive H₂O₂-responsive fluorescent probe for visualizing MC-LR-induced oxidative stress in vivo and verified that garlic extract can effectively alleviate its hepatotoxicity.
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An intelligent DNAzyme theranostic probe for in situ FTO bioimaging and real-time therapeutic efficacy evaluation in living cells

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00400H, Paper

Haorong Liu, Shengrong Yu, Rong Feng, Jingwen Chen, Gege Xie, Xiangwu Wu, Tao Zhang, Jian He, Yong-Xiang Wu, Keqi Tang
An intelligent DNAzyme theranostic probe (GF@ZD) integrates Fe²⁺-enhanced FTO activation and self-supplied Zn²⁺ for in situ bioimaging of endogenous active FTO, offering a versatile tool for efficacy evaluation and drug screening.
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A review on organic molecule-based fluorescent and colorimetric chemosensors for Bi3+: recent advances, challenges, and future directions

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00358C, Minireview

Saikat Kumar Manna, Sanchita Mondal, Arnab Rout, Subrata Mukhopadhyay
In recent years, the advancement of fluorometric and colorimetric chemosensors for Bi³⁺ ions has received notable attention from researchers owing to the pharmacological, environmental, and industrial relevance of Bi³⁺ ions.
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Revealing the biomolecular response of glioma cells to helium, carbon and oxygen minibeam radiation therapy using synchrotron-based infrared microspectroscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01327E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

R. González-Vegas, O. Seksek, S. Chiblak, S. Brons, A. Abdollahi, Y. Prezado, I. Yousef, I. Martínez-Rovira
The biomolecular impact of helium, carbon and oxygen minibeam radiation therapy on F98 and U-87 MG glioma cell lines is investigated by means of synchrotron radiation-based infrared microspectroscopy.
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Aptamer-based CRISPR-Cas12a fluorescent biosensors for serum biomarkers detection

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00123H, Minireview

Zhibing Chen, Haiqi Wu, Lok Ting Chu, Juncheng Lin, Yaning Zhang, Xiaocong Lin, Tao Zeng
The CRISPR-Cas12a system enables sensitive nucleic acid detection due to its programmability, trans-cleavage activity, and biocompatibility. To expand its applications beyond nucleic acid analysis, aptamers have emerged as an ideal...
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Correction: Development of a highly sensitive fluorescent light-up probe for G-quadruplexes

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN90043G, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ming-Hao Hu, Shuo-Bin Chen, Rui-Jun Guo, Tian-Miao Ou, Zhi-Shu Huang, Jia-Heng Tan
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Sulfur vacancy-mediated self-photocatalysis boosted electrochemiluminescence sensing via molecular oxygen activation for sensitive detection of isocarbophos

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00561F, Paper

Sheng Lei, Aiye Lu, Ding Jiang, Xue Wang, Zhidong Chen, Xiaojiao Du, Xueling Shan, Wenchang Wang
The luminol-dissolved oxygen electrochemiluminescence (ECL) system is fundamentally limited by the poor redox activity of oxygen, which fails to generate sufficient reactive oxygen species (ROS) for efficient luminol excitation, restricting...
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Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00455E, Paper

Monica Mazzarino, Thibo Colpaert, Koen Deventer, Peter Van Eenoo
Recently, methods for detecting small peptides in dried blood spots have been published.
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A fluorous-phase oxygen optical nanosensor for mitigating redox-active microbial metabolite interference

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00043F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

John M. Branning, Brianna M. Ruff, Samuel C. Saccomano, Avi I. Flamholz, Dianne K. Newman, Kevin J. Cash
Fluorous-phase oxygen nanosensors reduce pyocyanin-induced quenching by limiting metabolite partitioning while preserving O₂ sensitivity, enabling more stable and reliable oxygen measurements in redox-active biological environments.
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A hydrogel-confined Fe-MOF nanozyme sensor chip for matrix-tolerant colourimetric screening of malathion in Chinese medicinal matrices

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00495D, Paper

Zhiyi Zhou, Xiaoye Liu, Jia Yang, Mingyi Xue, Xinru Liu, Rong Rong, Tiantian Si
Hydrogel confinement stabilizes the Fe-MOF chromogenic microenvironment, enabling matrix-robust image-based screening of malathion in chemically heterogeneous Chinese medicinal extracts.
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Molecular imprinting-based pseudo-ELISA: recent advances

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00275G, Critical Review

Yuqin Ge, Hongkang Wang, Tianhai Ji
Molecularly imprinted polymers are emerging as an alternative to antibodies in conventional ELISA, either as the capture or detection element. This work has reviewed molecular imprinting-based pseudo-ELISA platforms reported over the past five years.
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Multi-omics profiling characterizes the primary cilium-related molecular regulatory landscape in systemic lupus erythematosus

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00149A, Paper

Mengqi Wei, Qinxin Zhang, Hao Xue, Donge Tang, Yong Dai, Wei Zhang
Integrative proteomic and phosphoproteomic analysis identifies primary cilium-associated molecular alterations and kinase-regulatory signatures in stable and active SLE.
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A reagent-free binding assay for cholera toxin based on sequestration electrochemistry using lactose-functionalized magnetic microbeads

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00392C, Paper

Mariwo Ikeuchi, K. S. Shalini Devi, Kazuto Sazawa, Kazuharu Sugawara, Hideki Kuramitz
A one-step, reagent-free electrochemical sensing strategy based on sequestration electrochemistry enables rapid and direct detection of cholera toxin using ligand-functionalized magnetic microbeads.
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Chemiluminescence microscopy single cell imaging using esterase triggered 1,2-dioxetanes

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00696A, Paper

Joshua T. Plank, Maidileyvis Castro Cabello, Rokia Osman, Gen Chen, Alexander R. Lippert
Chemiluminescence microscopy using emerging 1,2-dioxetane chemiluminescent probes is an attractive prospect for low background biological molecular imaging.
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Frontiers in Raman nano-diagnostics: SERS and TERS of extracellular vesicles for cancer detection

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00476H, Minireview

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lorena Veliz, François Lagugné-Labarthet
Vibrational spectroscopy and microscopy techniques are well adapted to the study of single extracellular vesicles providing composition of biomolecules with nanoscale resolution.
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Nanostructures for photoelectrochemical biosensing

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00334F, Critical Review

Qiuju Qiao, Xinrong Gu, Jing Li, Hongbo Li
Nanostructured platforms engineered for photoelectrochemical biosensing.
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Detection of H5 subtype avian influenza virus in avian oropharyngeal swab samples using a microfluidic non-competitive fluorescence polarization immunoassay

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00505E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Kazuki Takahashi, Yohei Takeda, Keine Nishiyama, Mao Fukuyama, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Ayuko Imai, Koji Shigemura, Akihide Hibara, Haruko Ogawa, Manabu Tokeshi
A microfluidic device-based fluorescence polarization immunoassay enables the detection of H5 subtype avian influenza viruses in avian oropharyngeal swab samples.
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Thermodesorption kinetics of nikethamide on oxidized tungsten surfaces

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00514D, Paper

Makhmanazar M. Nazarov, Ilkhomjon M. Saydumarov, Azim Sh. Radjabov, Shovkatjon Dj. Akhunov, Sherzod M. Akhmedov, Saida S. Iskhakova, Dilshadbek T. Usmanov
A voltage modulation system was developed and installed in a mass spectrometer. The thermodesorption kinetics of nikethamide was investigated under non-stationary conditions using the surface ionization method.
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A magnetic polymer adsorbent based on porous polystyrene microspheres for efficient extraction of conotoxins in biological fluids

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00324A, Paper

Xinlan Li, Songlin Liu, Yuan Luo, Shishi Liu, Xiujun Cao, Jun Lu, Chunhui Deng
Poly(DVB-co-NVP-co-VPA)-functionalized porous magnetic microspheres enable selective enrichment of conotoxins from biological fluids.
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Monitoring Food Spoilage Biogenic Amines Utilizing a Blue-Emitting Fluorescent Ionic Liquid

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00340K, Paper

Najmin Tohora, Biswajit Bhaumik, Rajkumar Sahoo, Sudhir Kumar Das
Biogenic amines are involved in numerous physiological processes and human health. For instance, putrescine and spermine (SPM) influence cell growth and division, while spermidine (SPD) offers neuroprotective, lifespan-promoting, and heart-protective...
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An ultra-performance convergence chromatography tandem mass spectrometry strategy for quantification of monodisperse polyethylene glycol polymers coupled with multiple fragmentation to enhance sensitivity

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00305B, Paper

Jiarui Zhang, Hui Miao, Jiale Liu, Xinyue Zhou, Yue Deng, Shuang Feng, Yalin Xi, Meiyun Shi, Lei Yin
UPC²-MS³ with supercritical CO₂ enables rapid (1.7 min) and selective quantification of monodisperse HO-PEG₈-OH in cell lysates, with MS³ eliminating matrix interference for trace-level analysis.
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Synthesis of rhodamine B hydrazine derivatives and their application in glycan analysis

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00299D, Paper

Yu-Nan Chen, Xiao-Long Hou, Ying Liu, Xu-Yang Shen, Yi-Xuan Gu, Yue Yu, Xin Zheng, Ying-Lin Zhou, Xin-Xiang Zhang
Due to the high molecular weight and polarity, glycans suffer low ionization efficiency in electrospray ionization mass spectrometry (ESI-MS).
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Impact of preparation methods and storage conditions for optimization of the fecal metabolome storage stability

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00237D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Vladyslav Dovhalyuk, Daniel Globisch
In this study, the impact of fecal sample collection, storage, and preparation of the metabolome was investigated. We have systematically evaluated these effects for storage stability across different stages of sample preparation protocols.
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Regeneration-on-a-chip: a planarian microfluidic device enabling automated cultivation, individual tracking and in vivo imaging for regeneration study

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00281A, Paper

Runtao Zhong, Xiaoyu Wang, Hui Li, Qi Zhang
This paper describes a planarian microfluidic device that enables automated cultivation, individual tracking and in vivo imaging for the regeneration study.
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Current trends in machine learning for surface-enhanced Raman spectroscopy

Analyst, 2026, 151,3357-3367
DOI: 10.1039/D5AN01346A, Critical Review

Ruihao Luo, Sujia Jiao, Jyothi B. Nair, Arna Ghosh, Klaudziya Kamiak, Jürgen Popp, Dana Cialla-May, Thomas Bocklitz
Surface-enhanced Raman spectroscopy (SERS) is being transformed by the widespread adoption of artificial intelligence across the full methodological spectrum.
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Dual-parameter self-calibrating probes for organelle polarity by decoupling viscosity from polarity

Analyst, 2026, 151,3368-3372
DOI: 10.1039/D6AN00249H, Communication

Lei Huang, Chuanhao Liu, Wenxiao Deng, Yuchang Tan, Yanfei Tan, Yan Huang
To overcome the limitations of intensity- or wavelength-based polarity sensing in cells, we developed a novel fluorophore utilizing steric hindrance to resist viscosity interference while maintaining high polarity sensitivity and PLQY.
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Biochemical composition of prostate core-needle biopsies before and after a single fraction of 13.5 Gy: a Raman spectroscopy-based study

Analyst, 2026, 151,3373-3384
DOI: 10.1039/D6AN00128A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kirsty Milligan, Mitchell Wiebe, Alejandra Fuentes, Sandra Popescu, Ramie Ali-Adeeb, Jeffrey Andrews, Julian Lum, Alexandre Brolo, Christina Haston, Bibi Naghibi Torbati, Juanita Crook, Andrew Jirasek
Raman spectroscopy for analysis and characterisation of patient biopsy response to brachytherapy. Carotenoids are found to play a significant role in response dynamics as observed via Raman spectroscopy.
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High-performance formic acid gas detection using a quartz crystal microbalance functionalized with Cdot-decorated polyvinyl acetate nanofibers

Analyst, 2026, 151,3571-3585
DOI: 10.1039/D6AN00209A, Paper

Chlara Naren Maharani, Henny Afiyanti, Firdausya Danuansa, Ihsan Nurijal, Roto Roto, Aditya Rianjanu, Kuwat Triyana, Witha Berlian Kesuma Putri, Rizky Aflaha
This study successfully obtained a high-performance formic acid sensor using Cdot-decorated PVAc nanofibers. The fabricated sensor shows a 20× sensitivity increase and high selectivity.
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Defect-coupled cooperative catalysis enables a highly active MOF-on-MOF nanozyme for direct discrimination of dihydroxybenzene isomers

Analyst, 2026, 151,3406-3417
DOI: 10.1039/D6AN00287K, Paper

Zhongfang Hu, Yuanyuan Sun, Xiaorong Sun, Yuming Dong, Guang-Li Wang
A defect-engineered MOF-on-MOF nanozyme with high oxidase-like activity was developed for direct discriminative recognition of resorcinol among dihydroxybenzene isomers.
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Evaluation of vardenafil's metabolic stability in human liver microsomes through ultra-fast UPLC-MS/MS for quantitative analysis, including assessments of greenness, ADME properties, DEREK alerts, and metabolic lability

Analyst, 2026, 151,3550-3561
DOI: 10.1039/D6AN00200E, Paper

Mohamed W. Attwa, Adnan A. Kadi
The current UPLC-MS/MS method is considered the first analytical method for vardenafil quantification in the HLMs matrix. Small changes to the 4-ethylpiperazine ring in drug design could improve the metabolic stability of new vardenafil derivatives.
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Quantitative analysis of sequential nucleic acid elution from silica paramagnetic beads

Analyst, 2026, 151,3541-3549
DOI: 10.1039/D6AN00127K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Asher Varon, Justin Schares, Kuangwen Hsieh, Bradley Downs, Tza-Huei Wang
Paramagnetic beads enable diverse biochemical assays. A systemic investigation into sequential nucleic acid elution, was quantitatively characterized across multiple elution steps.
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Photothermal microscopy beyond intensity detection: exploiting spatial signal distributions for enhanced sensitivity

Analyst, 2026, 151,3586-3591
DOI: 10.1039/D6AN00046K, Paper

Shu-hei Urashima, Tomotaro Namba, Ryoji Kusaka
Exploiting pump–probe spatial mismatch enables up to a sixfold improvement in the limit of detection for photothermal microscopy beyond conventional spectrophotometers while preserving microscopic spatial resolution.
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A pH-responsive ratiometric fluorescent probe and its application in bioimaging and food freshness monitoring

Analyst, 2026, 151,3391-3396
DOI: 10.1039/D6AN00471G, Paper

Huan Wang, Tao Zhang
A water-soluble ratiometric fluorescent probe with dual-emission upon single excitation has been successfully developed for tracking pH changes within mitochondria and for detecting food freshness.
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A new benzothiazoloacetonitrile-derived fluorescent probe for selective hydrazine detection and its applications in bioimaging and cotton swab analysis

Analyst, 2026, 151,3501-3512
DOI: 10.1039/D6AN00062B, Paper

Nikita Kush Durgi, Ramesh D. K., Kiran B. Manjappa, Prasad Pralhad Pujar
A new benzothiazoloacetonitrile-based fluorescent probe was synthesised for hydrazine detection with an LOD value of 0.21 µM and was employed in bioimaging and cotton swab applications.
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Feasibility study of superoxide chemical ionization mass spectrometry (O2− CIMS) for real-time gas-phase measurements of per- and polyfluoroalkyl substances (PFAS)

Analyst, 2026, 151,3418-3429
DOI: 10.1039/D5AN01352F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yufan Hu, Joji W. Sherman, Michael J. Davern, Zane A. Alsebai, Yoonsub Kim, Yue Zhang, Chenyang Bi, Barbara J. Turpin, Jason D. Surratt
O₂⁻ as a CIMS reagent ion enables safer usage and fingerprint ion peaks for PFAS compound confirmation while providing higher sensitivity and lower limits of detection for real-time gas-phase measurements of several PFAS compared to current methods.
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Microscope observation of united liposome trajectories near a polarized ultramicroelectrode surface

Analyst, 2026, 151,3562-3570
DOI: 10.1039/D6AN00252H, Paper

Arthur Langlard, Christine Thobie-Gautier, Mohammed Boujtita, Estelle Lebègue
An ultramicroscopy setup built for tracking the positions of liposomes, in the plane of their trajectories between the bulk solution and the ultramicroelectrode disk surface that is polarized during blocking impact experiments.
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Non-invasive detection of Oncostatin M and TNF-α in a microphysiological chip with embedded pH tuning capabilities

Analyst, 2026, 151,3470-3488
DOI: 10.1039/D5AN00949A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Daniele Bellisario, Alessandra Calogiuri, Elisa Sciurti, Laura Blasi, Vanessa Esposito, Flavio Casino, Pietro Siciliano, Antonio Della Torre, Luca Francioso
Schematic of the microphysiological chip with pH tuning capabilities and data processing chain.
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The non-linear effects of the number of stochastic single-molecule adsorption events on ensemble elution profiles

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00199H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ricardo Monge Neria, Rachel A. Saylor, Lydia Kisley
The stochastic model of chromatography mathematically links microscopic, molecular adsorption times to chromatographic elution. The nonlinear effects of the number of adsorption events and number of modeling points on elution profiles are explored.
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Multiplexed profiling of breast cancer exosomes based on an asymmetric bipolar electrode electrochemiluminescence immunochip

Analyst, 2026, 151,3430-3441
DOI: 10.1039/D6AN00356G, Paper

Xin Hua, Jianmei Han, Tingting Han, Gaohua Han, Wei Zhang, Ran Chen, Songqin Liu
A four-channel asymmetric bipolar electrode-based microfluidic chip was developed for highly sensitive and multiplexed profiling of breast cancer exosomes.
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Data-driven optimization for controllable multi-scale aperture fabrication of nanopipettes

Analyst, 2026, 151,3592-3600
DOI: 10.1039/D6AN00232C, Paper

Runan Guo, Zhi Chen, Xue Han, Rongke Sun, Hui Lu, Yanqing Ma, Lei Ma
This work realizes controllable multiscale aperture fabrication of nanopipettes (50–1000 nm) integrates an artificial neural network, feature importance analysis, and a mechanical physical model.
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Molybdenum disulfide quantum dots as dual-functional catalysts and coreactants for enhanced Ru(bpy)32+ electrochemiluminescence

Analyst, 2026, 151,3397-3405
DOI: 10.1039/D6AN00290K, Paper

Xiu Yang, Jianjun Shi, Hui Zhu, Changjie Mao
Schematic of Ru(bpy)₃²⁺-ECL enhancement by MoS₂ QDs and ECL quenching by DA.
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Multi-modal structure characterization of synthetic batch impurities with liquid chromatography coupled to infrared ion spectroscopy

Analyst, 2026, 151,3453-3459
DOI: 10.1039/D5AN01339A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Teun van Wieringen, Simon J. Perry, Agisilaos Chantzis, Giel Berden, Jos Oomens, Mansoor Saeed, Jonathan Martens
By combining IR ion spectroscopy, chromatography and quantum-chemical spectral predictions, five synthetic impurities are identified. Born-Oppenheimer molecular dynamics calculations are used to improve the spectral predictions.
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Simultaneous quantitation of structurally analogous bile acid isomers via charge-state-engineered UPLC-MS

Analyst, 2026, 151,3513-3521
DOI: 10.1039/D6AN00420B, Paper

Desen Su, Yunyun Zheng, Xiuxian Lin, Ziqiang Chen, Minmin Huang, Qinghua Yao, Yuwu Chi
An advanced UPLC-MS approach utilizing alkaline charge-state homogenization efficiently separates four bile acid isomers (ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, and deoxycholic acid), providing high sensitivity and robust quantification in complex biological matrices.
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Upcycling lemon peel waste into sustainable bioactive ingredients: chemical characterization and efficacy assessment

Analyst, 2026, 151,3489-3500
DOI: 10.1039/D6AN00048G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ritamaria Di Lorenzo, Ilaria Neri, Raffaele Raimondo, Daniela Di Matteo, Carlo Irace, Maria Grazia Ferraro, Mariavittoria Verrillo, Teresa Ponticorvo, Teresa Di Serio, Sonia Laneri, Lucia Grumetto
Supercritical fluid extraction of bioactive compounds from dried lemon peel, an agro-industrial waste, to support sustainable valorization strategies.
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Quantitative metabolomics identifies prognostic biomarkers associated with NSCLC after chemoradiotherapy

Analyst, 2026, 151,3531-3540
DOI: 10.1039/D6AN00069J, Paper

Leirui Yuan, Linfang Wu, Mingmin Qian, Chenxi Li, Daquan Wang, Xiang Fang, Shanlin Mao, Di Yang, Minghao Wang, Luhua Wang, Zeper Abliz, Nan Bi, Yanhua Chen
Targeted quantitative metabolomics of pretreatment plasma identified GSH and LPC18:3 as prognostic biomarkers in stage III NSCLC. High GSH predicted better survival, whereas high LPC18:3 indicated a poorer outcome after chemoradiotherapy.
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Selective detection of lipophagy with a highly specific lipid droplet probe

Analyst, 2026, 151,3522-3530
DOI: 10.1039/D5AN01241D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shixiong Wen, Xiaoxue Zou, Jianing Liu, Jiahuai Han, Shoufa Han
Lipophagy, the autophagic degradation of lipid droplets (LDs) by lysosomes, is an important route for maintaining LD homeostasis.
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Reusable interface-decoupled organic photoelectrochemical transistor biosensing for acetylcholinesterase activity and its inhibitor detection

Analyst, 2026, 151,3385-3390
DOI: 10.1039/D6AN00315J, Paper

Huijin Lin, Huihui Cai, Hua-Yue Xiong, Jinting Sun, De-Man Han, Feng-Zao Chen, Chaobiao Huang
An innovative interface-decoupled organic photoelectrochemical transistor (ID-OPECT) sensor was developed, featuring an external photon-gating module for highly responsive and reusable acetylcholinesterase and chlorpyrifos detection.
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Applying systems thinking to analytical system development for managing the antimicrobial resistance crisis

Analyst, 2026, 151,3317-3356
DOI: 10.1039/D5AN01182E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Rebecca X. Y. Chen, Rayane Azani, Kayla Elliott, Sarah Jane Payne, R. Stephen Brown, Zhe She
Antimicrobial resistance (AMR) is a global, cross-sectoral crisis spanning clinical, agricultural, and environmental systems. Advances in rapid, standardized detection methods are key to enabling real-time monitoring and informed interventions.
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On-site amplification-free electrochemical detection of the plant pathogen Xylella fastidiosa via cathodic potential-induced DNA adsorption

Analyst, 2026, 151,3442-3452
DOI: 10.1039/D6AN00096G, Paper

Farjana Haque, Kiran Shrestha, Fatema Zerin Farhana, Moutoshi Chakraborty, Md Akeruzzaman Shaon, Milkiyas Toru Tantu, Omar Hamza Bin Manjur, Sharmin Aktar, Kevin M. Koo, Tanveer Hussain, Geoff M. Gurr, Muhammad J. A. Shiddiky
An amplification-free electrochemical assay detects Xylella fastidiosa via 30 s cathodic DNA adsorption on gold, achieving 100 aM sensitivity. Integrated with a 3D-printed sap extraction device, it enables rapid, field-deployable surveillance.
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Dielectric barrier discharge ionization (DBDI) enables rapid analysis of new psychoactive substances with ion mobility-mass spectrometry

Analyst, 2026, 151,3460-3469
DOI: 10.1039/D6AN00028B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Bradley B. Garrison, Copeland R. Johnson, Ralph Aderorho, Christopher D. Chouinard
Combining dielectric barrier discharge ionization (DBDI) with ion mobility (IM) separations provides rapid separation of drug isomers and protomers.
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Colloidal gold immunochromatographic assay for mycophenolic acid in human plasma

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00484A, Paper

Jiayi Liu, Lingling Guo, Liqiang Liu, Xinxin Xu, Hua Kuang, Chuanlai Xu
An antibody-based colloidal gold immunochromatographic assay was developed for the rapid detection of mycophenolic acid in plasma.
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Advanced X-ray radiographic imaging analysis for identifying the water dynamics regime of polymer electrolyte fuel cells

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00365F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Wataru Yoshimune
A fluctuation-oriented framework was developed for operando X-ray radiography. Combined entropy and temporal autocorrelation analyses revealed hidden spatial heterogeneity in water fluctuation behaviour within gas diffusion layers.
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Ultrasensitive triple-mode Nile red-L64 niosome nanothermometers for real-time cellular thermogenesis mapping

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00434B, Paper

Ronak Lazarus, Rupal Kothari, Venkata Vamsi Krishna Venuganti, Amit Nag
The gel-to-liquid phase transition of L64 niosomes loaded with Nile red enables a highly sensitive triple-mode fluorescence nanothermometer for intracellular temperature monitoring over the human physiological range of 37–39 °C.
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