RSC - Analyst latest articles

Feasibility Study of Superoxide Chemical Ionization Mass Spectrometry (O2- CIMS) for Real-time Gas-Phase Measurements of Per- and Polyfluoroalkyl Substances (PFAS)

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01352F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yufan Hu, Joji W. Sherman, Michael J. Davern, Zane A. Alsebai, Yoonsub Kim, Yue Zhang, Chenyang Bi, Barbara J. Turpin, Jason D. Surratt
Per- and polyfluoroalkyl substances (PFAS) are highly persistent pollutants with known adverse impacts on environmental and public health. Traditional gas-phase PFAS detection approaches often involve labor-intensive sample collection and preparation,...
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Microscope observation of united liposome trajectories near a polarized ultramicroelectrode surface

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00252H, Paper

Arthur Langlard, Christine Thobie, mohammed BOUJTITA, Estelle Lebegue
An optical setup, based on ultramicroscopy principles, was built to track and measure the velocities of phospholipid liposomes in the vicinity of a polarized ultramicroelectrode. This custom device allowed to...
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Advances and opportunities in point-of-care detection of toxic metals: a review of electrochemical and non-electrochemical approaches

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00248J, Critical Review

Navoda Udawaththa, Olga Zubak, Ashley Daninger, Ralph Page, Miriam Strini, Brianna Romero, Pavithra Pathirathna
Heavy metal contamination remains a persistent global threat to human health and the environment, driving the urgent need for rapid, portable, and sensitive detection technologies.
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Multi-modal structure characterization of synthetic batch impurities with liquid chromatography coupled to infrared ion spectroscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01339A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Teun van Wieringen, Simon J. Perry, Agisilaos Chantzis, Giel Berden, Jos Oomens, Mansoor Saeed, Jonathan Martens
By combining IR ion spectroscopy, chromatography and quantum-chemical spectral predictions, five synthetic impurities are identified. Born-Oppenheimer molecular dynamics calculations are used to improve the spectral predictions.
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Fluorescent nanodiamonds: preparation and quantum sensing for biological analysis

Analyst, 2026, 151,2447-2467
DOI: 10.1039/D6AN00103C, Minireview

Shingo Sotoma, Kota Shiraya, Daisuke Fujimaki, Kai Otsu
Fluorescent nanodiamonds containing nitrogen-vacancy centers are next-generation bioprobes. This Minireview outlines their preparation and surveys their applications to intracellular temperature, radical, and rotational sensing.
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Reusable interface-decoupled organic photoelectrochemical transistor biosensing for acetylcholinesterase activity and its inhibitor detection

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00315J, Paper

Huijin Lin, Huihui Cai, Hua-Yue Xiong, Jinting Sun, De-Man Han, Feng-Zao Chen, Chaobiao Huang
An innovative interface-decoupled organic photoelectrochemical transistor (ID-OPECT) sensor was developed, featuring an external photon-gating module for highly responsive and reusable acetylcholinesterase and chlorpyrifos detection.
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A nanopore-based enzyme-assisted biomarker detection method for chronic obstructive pulmonary disease

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00373G, Paper

Qianyuan Ren, Yakun Yi, Shihong Li
We present a nanopore-based dual-biomarker assay for ultrasensitive miR-150-5p and VEGF165 detection, providing a promising method for early screening of Chronic obstructive pulmonary disease (COPD) and its associated pulmonary hypertension.
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Visualizing nanoplastic–metal ion co-exposure stress with an NIR biothiol responsive fluorescent probe

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00278A, Paper

Shaoyu Wei, Liangwei Zhang, Jiangkun Tan, Shudi Liu, Maryam Arabi, Abbas Ostovan, Xuming Zhuang, Lingxin Chen
A near infrared biothiol fluorescent probe has been developed for studying nanoplastic–metal ion complex co-exposure induced oxidative stress, revealing that charge and lysosomal function may be involved in the process.
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Organoid models through the lens of metabolomics: a systematic review of experimental applications and analytical approaches

Analyst, 2026, 151,2489-2503
DOI: 10.1039/D6AN00186F, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Martina Lombardi, Andrea Ingenito, Antonietta Santoro, Jacopo Troisi
Organoid models have transformed experimental biology by enabling three-dimensional systems that recapitulate tissue architecture, cellular heterogeneity, and metabolic activity patterns more faithfully than conventional in vitro cultures.
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Electrochemiluminescence of a novel iridium(III) complex with dual-potential emission and its application in chloramphenicol sensing

Analyst, 2026, 151,2528-2532
DOI: 10.1039/D6AN00173D, Communication

Tongtong Li, Yingying Su, Mingxia Sun, Hongjie Song, Yi Lv
Three Ir(C^N)₂(N^N)⁺ complexes with the same C^N ligand and different N^N ligands were synthesized, and their ECL properties were systematically investigated using TPA or K₂S₂O₈ as coreactants.
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From materials to systems: recent advances on electrochemical sensors for capsaicin detection

Analyst, 2026, 151,2423-2446
DOI: 10.1039/D5AN01193K, Minireview

Huirou Zhou, Shasha He, Rahim Rahimi, Hongjie Jiang
Recent advances in electrochemical capsaicin detection, highlighting progress in electrode sensing materials and their translation into sensing technologies.
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Advances in single-molecule junctions for the detection of hazardous pollutants

Analyst, 2026, 151,2504-2522
DOI: 10.1039/D5AN01256B, Tutorial Review

Long-Long Zhou, Jun-Hua Chen, Li-Na Luo, Jia-Ying Huang, Ya-Hao Wang, Shaoshao Jiao, Xiao-Shun Zhou
This graphical abstract shows single-molecule junctions (SMJs) as ultrasensitive platforms for pollutant detection, covering inorganic, organic, and microbial pollutants, as well as current challenges and future directions.
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State-of-the-art of surface-enhanced Raman spectroscopy for pathogenic bacterial identification

Analyst, 2026, 151,2468-2488
DOI: 10.1039/D6AN00039H, Critical Review

Juntian Jiang, Chao Yan, Sibo Wang, Bing Zhao, Xuesong Xu, Weidong Ruan, Xiang Wang
SERS enables rapid, sensitive bacterial identification. This review highlights advances in substrates, sample enrichment and AI/ML spectral analysis, and outlines key challenges for standardised clinical translation.
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Lyophilised colourimetric LAMP for visual readout with dual colour indicators

Analyst, 2026, 151,2650-2661
DOI: 10.1039/D5AN01238D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kenny Malpartida-Cardenas, Oliver W. Stringer, Matthew L. Cavuto, Alison Holmes, Jesus Rodriguez-Manzano
Development and optimisation of ready-to-use lyophilised colourimetric LAMP (lyo-cLAMP) integrating pH and metal indicators, only requiring addition of extracted nucleic acids. Compatible with any LAMP assay, it enables adaptation to any target.
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Glycan signal enhancement by ammonium fluoride doping and electrospray diverting

Analyst, 2026, 151,2704-2710
DOI: 10.1039/D6AN00090H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Seth M. Eisenberg, David C. Muddiman
By combining ammonium fluoride electrospray doping with an electrospray diverter, signals of N-linked glycans were significantly enhanced.
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Stable focusing of proteins within a packed microbead bed by ion concentration polarization in a paper-based analytical device

Analyst, 2026, 151,2638-2649
DOI: 10.1039/D6AN00004E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sommer Osman, Kira L. Rahn, Quinlan G. Pollak, Md Ruhul Amin, Robbyn K. Anand
Embedded beads stabilize electrokinetic preconcentration in a paper LFA, while antibody functionalization enables antigen retention after the electric field is removed.
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A hollow-core fiber based optofluidic chip for rapid immunofluorescence detection with simultaneous enhancement of sensitivity and enrichment efficiency

Analyst, 2026, 151,2602-2612
DOI: 10.1039/D5AN01308A, Paper

Xiao Ren, Tian Wen, Yukai Liu, Xiaoxian Liu, Feng Lin, Zhenyong Dong, Hao Wang, Lunbiao Cui, Yan-qing Lu, Guanghui Wang
An optical microfluidic chip integrating a functionalized hollow-core fiber achieves rapid and highly sensitive detection of influenza A virus through waveguide-confined fluorescence excitation enhancement and efficient collection.
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High- and low-field NMR in binary solvent gradients

Analyst, 2026, 151,2662-2668
DOI: 10.1039/D6AN00031B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Haider Hussain, Paulina Putko, Dariusz Gołowicz, Krzysztof Kazimierczuk, Matthew Wallace
Gradients in the solvent composition of NMR samples are generated by layering two solvents of contrasting densities. Spectra are recorded at different compositions by physical movement of the tube (low-field) or chemical shift imaging (high-field).
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A spatially invariant noise model for minimum noise fraction (MNF) denoising of hyperspectral datasets: applications to large-scale infrared spectroscopic pathology

Analyst, 2026, 151,2624-2637
DOI: 10.1039/D6AN00152A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dougal Ferguson, Peter Gardner
A spatially invariant version of the Minimum Noise Fraction denoising algorithm (iMNF) that removes the spatial-order dependency of standard MNF, keeping biochemical fidelity across unstructured datasets or datasets analysed in a patch-wise manner*.
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A machine learning-assisted Cu-MOF/OPD/RB triple-emission ratiometric fluorescence sensing platform for the detection and discrimination of glutathione

Analyst, 2026, 151,2584-2592
DOI: 10.1039/D6AN00116E, Paper

Shiwen Wu, Shuqi Wang, Hui Xie, Yaxin Li, Hongzhi Lu, Shuzhen Zheng, Shuai Sun, Shoufang Xu
Preparation of a Cu-MOF and the construction of a triple-emission ratiometric fluorescent probe (A); the ratiometric fluorescence detection of GSH (B); and the machine learning-assisted intelligent discrimination of analogous substances (C).
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Simultaneous qualitative and quantitative analysis of tyloxapol in tobramycin eye drops by LC-Q-TOF and HPLC-ELSD

Analyst, 2026, 151,2694-2703
DOI: 10.1039/D6AN00042H, Paper

Shengjun Che, Chen Liang, Min Yan, Xiaoru Zhang, Wenfeng Zheng
An innovative combined qualitative and quantitative method for detecting the content of tyloxapol in tobramycin eye drops.
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Machine learning-driven multidimensional tea profiling from a single SERS spectrum: toward practical application

Analyst, 2026, 151,2711-2720
DOI: 10.1039/D6AN00093B, Paper

Jincheng Ni, Yanyan Lu, Xuewen Chen, Haoming Bao, Yu Qiao, Shuai Zhang, Daoshuan Ding, Jiamei Jin, Huaiyuan Zhao, Qian Zhao, Jinhua Wang, Hongwen Zhang, Weiping Cai
A single SERS spectrum, analysed using machine learning, enables multidimensional tea authentication, resolving category, grade, storage quality, and pesticide residues with up to ≥98.9% accuracy, moving toward practical application.
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Micro-SORS and machine learning for the non-invasive reference-free study of subsurface pigment degradation

Analyst, 2026, 151,2563-2573
DOI: 10.1039/D5AN01176K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

A. Lux, J. Schlanz, A. Botteon, L. Monico, P. Matousek, R. I. Dima, C. Conti, P. Strobbia
The study presents the development of micro-spatially offset Raman spectroscopy (micro-SORS) methods and data analysis routines for the study of pigment degradation processes in the cultural heritage field.
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Classification of recycled plastics using sparse and imbalanced spectral data and data augmentation by the generative adversarial network

Analyst, 2026, 151,2552-2562
DOI: 10.1039/D5AN01042J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xuan Liu, Xuerui Song, Yusuf Sulub, David Zoller, Zhenyu (James) Kong, Blake N. Johnson
Data augmentation with a Generative Adversarial Network improves FTIR spectra classification for accurate plastic sorting and recycling applications.
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Utilizing Venturi effect for automated high-throughput droplet-MS from well plates

Analyst, 2026, 151,2533-2543
DOI: 10.1039/D6AN00065G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Bridget E. Murray, Roger C. Diehl, Moritz Pott, Daniel A. Holland-Moritz, Alison R. H. Narayan, Robert T. Kennedy
We demonstrate a high-throughput (0.4 samples per s) and automated droplet-MS method for analysis of enzyme reactions.
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An adaptive weighted polynomial baseline correction method for electrochemical aptamer-based sensors

Analyst, 2026, 151,2669-2681
DOI: 10.1039/D5AN01347J, Paper

Zhijian Wen, Yasmin Liu, Emeka J. Itumoh, Janet Stacey, James M. Curran, Onyekachi Raymond
An adaptive polynomial baseline correction method developed for square-wave voltammetry (SWV) data to identify non-informative regions, apply weighted polynomial fitting, and select the optimal order for accurate baseline estimation.
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Electrokinetic separation of bacteriophage ϕKZ from bacterial cells

Analyst, 2026, 151,2682-2693
DOI: 10.1039/D5AN01220A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Viswateja Kasarabada, Zakia Azad, Julie A. Thomas, Blanca H. Lapizco-Encinas
Binding-induced zeta potential shifts facilitated the electrokinetic streaming separations of bacteriophage ϕKZ from Escherichia coli at 194.3 V/cm and 430.4 V/cm. A streaming–trapping approach selectively immobilized bacterial cells at 580.6 V/cm.
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Focused traveling surface acoustic wave-based acoustofluidic chip for label-free cell sorting

Analyst, 2026, 151,2613-2623
DOI: 10.1039/D5AN01350J, Paper

Jingxiang Deng, Yang Yang, Zixin Wang, Haiping Zhao, Hao Chen, Lingqian Zhang, Mingxiao Li, Yang Zhao, Chengjun Huang
A label-free FTSAW acoustofluidic chip enabling red and white blood cell sorting.
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Chaperone polymer-enhanced microRNA sensing on a surface-functionalised power-free microchip

Analyst, 2026, 151,2523-2527
DOI: 10.1039/D6AN00188B, Communication

Ryo Ishihara, Kotomi Katori, Manaya Ogawa, Mutsumi Hosono, Yingfan Mu, Ren Ogata, Hinako Yokohari, Rin Hirose, Eri Shimura, Takeshi Baba, Naoko Yoshida, Naoki Yoshida, Atsushi Maruyama
Artificial chaperone polymer-enhanced hybridisation enabled the sensitive and specific detection of hsa-miR-500a-3p, a liquid biopsy biomarker, from a 1.0 µL sample within 15 minutes using a portable surface-functionalised power-free microchip.
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Construction of a smartphone-assisted colorimetric nanosensor with multi-antibiotic response based on silver–ceria nanocomposites mimicking peroxidase activity

Analyst, 2026, 151,2574-2583
DOI: 10.1039/D6AN00082G, Paper

Yinxia Yang, Yi Liu, Jialin Liang, Qian Zhao, Shi Gang Liu, Jie Luo
A smartphone-assisted colorimetric nanosensor with multi-antibiotic response based on silver–ceria nanocomposites mimicking peroxidase activity is designed and applied for rapid detection of antibiotics in real samples.
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Super-lightweight, low-cost and wireless water quality monitor for remote chlorine rate management in water-circulating cooling facilities

Analyst, 2026, 151,2593-2601
DOI: 10.1039/D6AN00029K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Masayuki Kawakami, Toshihiro Kasama, Tomomi Sato, Hidekatsu Tazawa, Madoka Takai, Daisaku Yano, Ryo Miyake
A compact wireless residual chlorine monitor was developed using a glass mixing and reaction device and an absorbance flowcell. The monitor tracked chlorine concentration changes during the chlorine injection process in a circulating cooling system.
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Molecular imprinting of aptamer/carbamazepine complexes for the development of an optical nanosensor

Analyst, 2026, 151,2544-2551
DOI: 10.1039/D5AN01268F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Iqra Salim, Eleanor Fiona Richards, Jon Ashley
An on/off optical sensor for the detection of carbamazepine.
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Facile and scalable fabrication of molecularly imprinted polymer (MIP) sensors on poriferous laser-engraved graphene electrodes for stress monitoring

Analyst, 2026, 151,2721-2734
DOI: 10.1039/D4AN01389A, Paper

Atul Sharma, Rachel E. Owyeung, Ayanna Thomas, Sohel Siraj, Bishal Kumar Keshari, Parikshit Sahatiya, Sameer Sonkusale
Monitoring cortisol levels is essential for understanding the body's response to stress.
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Surface-Enhanced Raman Spectroscopy for Comprehensive Urinalysis: Advances, Challenges, and Clinical Perspectives

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00201C, Tutorial Review

Si Chen, Yuemei Chen, Yuxin Liu, Chunying Zhang, Jianke Yanga, Xiaoqin Xu, Tonghao Zhang, Yali Song, Tingting Zeng
Urine is an information-rich, noninvasive biofluid that reflects systemic and urological physiology through endogenous metabolites, disease-associated biomarkers, and residues of therapeutic drugs. Surface-enhanced Raman spectroscopy (SERS) has emerged as a...
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Non-invasive detection of Oncostatin M and TNF-α in a microphysiological chip with embedded pH tuning capabilities

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00949A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Daniele Bellisario, Alessandra Calogiuri, Elisa Sciurti, Laura Blasi, Vanessa Esposito, Flavio Casino, Pietro Siciliano, Antonio Della Torre, Luca Francioso
Schematic of the microphysiological chip with pH tuning capabilities and data processing chain.
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The non-linear effects of the number of stochastic single-molecule adsorption events on ensemble elution profiles

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00199H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ricardo Monge Neria, Rachel A Saylor, Lydia Kisley
The stochastic model of chromatography mathematically represents the molecular mass transfer that occurs during a separation. Single-molecule microscopy allows for direct visualization of molecular analytes adsorbing within column materials. Experimental...
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Advances of hydrogel modified silica as the stationary phase in high performance liquid chromatography

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00404K, Perspective

Tong Zhang, Xiaojing Liang, Hongfang Lin, Rui Liu, Na Li, Zhixia Li, Lei Liu, Yuting Zhang
In chromatographic technology, the stationary phase is of paramount importance, with its properties intrinsically linked to both the separation performance and the mode of chromatography employed. The study of stationary...
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A two-point fluorescence detection flow cell with empirical calibration for high optical density analysis

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00106H, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Tin Weitner, Davor Šakić
A dual-detector fluorescence flow cell with software calibration enables accurate quantification at previously inaccessible high optical densities.
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Differentiation of Disaccharide Isomers via Diagnostic-Ion-Weighted Spectral Library Searching using Data from Tandem MS Analysis of Chloride Adducts

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00268D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shixiang Xu, Abraham K. Badu-Tawiah, Santosh R. Acharya, Ruth Speidel
Rare sugars, comprising of over 50 known saccharide isomers, have broad significance in food science, pharmaceuticals, and biomedical applications. However, the inherent structural complexity (due to isomerization) and low natural...
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Multiplexed Profiling of Breast Cancer Exosomes Based on an Asymmetric Bipolar Electrode Electrochemiluminescence Immunochip

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00356G, Paper

Xin Hua, Jianmei Han, Tingting Han, Gaohua Han, Wei Zhang, Ran Chen, Songqin Liu
Early and sensitive diagnosis is critical for improving the survival rate of breast cancer patients. However, the early detection of triple-negative breast cancer (TNBC) remains a significant challenge due to...
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A novel electrochemiluminescence sensor using Lu-Au@Ni-MOF for ultra-sensitive detection of permethrin

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00409A, Paper

Yahui Ji, Nana You, Xiaoping Hu, Fangxin Du, Hui Gao, Jie Ru, Gen Liu
Herein, we report a novel and highly sensitive electrochemiluminescence (ECL) sensor for the detection of permethrin (PT). This sensor is constructed based on a nanocomposite in which luminol-reduced gold nanoparticles...
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Data-Driven Optimization for Controllable Multi-Scale Aperture Fabrication of Nanopipettes

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00232C, Paper

Runan Guo, Zhi Chen, Xue Han, Rongke Sun, Hui Lu, Yanqing Ma, Lei Ma
This study addresses the critical challenge of controllable nanopipette fabrication by proposing a multi-parameter collaborative optimization framework that combines an artificial neural network (ANN) with a physical model. The ANN...
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Molybdenum Disulfide Quantum Dots as Dual-Function Catalysts and Coreactants for Enhanced Ru(bpy)32+ Electrochemiluminescence

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00290K, Paper

Xiu Yang, Jian-Jun Shi, Hui Zhu, Chang-Jie Mao
Electrochemiluminescence (ECL) is a powerful tool for clinical diagnosis due to its exceptionally sensitive characteristics. In this work, an enhanced and stable anodic ECL was observed in the suspension of...
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Cellular level lipidomics of two-dimensional cultures of adherent gut epithelial cell lines confirms a metabolic switch

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01183C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Qianying Xu, Jake A. Penny, Emily Fraser, Federica Orsenigo, Matteo Barberis, Lee A. Gethings, Melanie J. Bailey, E. N. Clare Mills
Advances in lipidomics analysis at a cellular level highlight important metabolic differences between Caco-2 and HT29-MTX cell lines which are widely used to study gut uptake and metabolism of nutrients and pharmaceuticals.
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Interpretable machine learning model-driven electrochemical impedance spectroscopic analysis for the determination of nitrate, nitrite, and ammonium ions in water

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01279A, Paper

K. Reji, Ramakrishnan Vishnuraj, Adithyakrishna Narayanaswamy, Vishnuvarthan Rajagopal, S. Vishnu, Murali Rangarajan
A machine-learning framework combining hybrid tree, principal component analysis, and stacked ensemble models is used to predict concentrations of nitrate, nitrite and ammonium ions in water from electrochemical impedance spectroscopy measurements.
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Zinc finger protein arrays in an epoxy-functionalized, pump-free microfluidic device for amplification-free, colorimetric detection of double-stranded DNA

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00224B, Paper

Shaikh Al Mahmud Bhuiyan, Rylan Shumway, Christine Trinkle, Moon-Soo Kim
Pump-free microfluidic ZFP arrays with dual-surface covalent immobilization enable rapid, amplification-free, colorimetric detection of pathogen dsDNA, offering a platform for translating programmable protein–DNA recognition into POC diagnostics.
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GravSorter: a forward-genetics tool for studying gravity response in Caenorhabditis elegans

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01231G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Hui Ma, David M. Raizen, Haim H. Bau
GravSorter: Diverse genotypes are placed in a vertical liquid column slightly denser than the worms. Gravitaxis-competent worms swim downward, while deficient worms float and are collected for downstream sorting and sequencing.
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Analysis of cholesterol-induced mechanical modulation of cell membranes by nanopipette-generated fluid flow

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00067C, Communication

Shu-Yue Xu, Meng-Qi Zhao, Xin-Yue Liu, Ming-Jie Ye, Bin-Bin Chen, Da-Wei Li, Mahmoud Elsayed Hafez, Jian Lv, Ruo-Can Qian
A label-free membrane oscillation strategy based on nanopipette-generated fluid flow to investigate cholesterol-induced mechanical alterations in living cell membranes.
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DNA nanotechnology for nucleic acid analysis: detection of RNA and dsDNA amplicons using a multifunctional DNAzyme nanomachine (DNM)

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00265J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Muhannad Ateiah, Sofia S. Zablotskaya, Maria S. Rubel, Dmitry M. Kolpashchikov
A multivalent 10–23 DNAzyme-based molecular nanomachine (DNM) enables sensitive, selective, and amplification-free detection of structured ssRNA and dsDNA.
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A metaproteomic platform for integrated host-pathogen-microbiota profiling in zebrafish larvae

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00088F, Communication

Javiera Ortiz-Severín, Antonia Ramos-Guzmán, Ian Pérez, Miguel L. Allende, Francisco P. Chávez
Understanding host–pathogen–microbiota interactions requires analytical strategies capable of resolving multiple biological compartments within a single experimental framework.
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Monte Carlo-like peaks assignment using a time-resolved in situ NMR approach for complex reaction monitoring: a case study of the photodegradation of retinyl acetate

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00072J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Farwa Khalid, Chunchesh Malangi Gajendramurthy, Franz F. Westermair, Lena Miler, Ruth M. Gschwind, Tomasz Ratajczyk, Mateusz Urbańczyk
We demonstrate a method for complex reaction monitoring that combines two approaches: time-resolved non-uniform sampling and time-resolved diffusion NMR. The new approach was demonstrated in the study of the photodegradation of retinyl acetate.
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Effect of O-acetylation on ketene and carbonyl yields from conventional and emerging cannabinoids

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00190D, Paper

Rhianna L. Evans, C. Noel Corley, Haylee C. Hunsaker, Sascha C. T. Nicklisch, Allison K. Ehrlich, Tran B. Nguyen
The vaping of popular and emerging cannabinoid O-acetates leads to the formation of ketene and carbonyls in high yields (1–5%), exceeding NIOSH safety limits of inhalation toxicity and indicating further regulation of these products is required.
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Hydropyrolysis: towards fluorescence-free Raman spectroscopy analysis of internal diesel injector deposits

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00347D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Joel Viggars, Sarah Angel-Smith, Graham A. Rance, Ahmed Khairy, Will Meredith, Adrienne Davis, Jim Barker, Jacqueline Reid, David J. Scurr, Colin E. Snape
The application of hydropyrolysis (HyPy) to a series of Internal Diesel Injector Deposits (IDIDs) has significantly reduced the observed fluorescence and enabled acquisition of structurally-informative Raman spectra for the first time.
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HDX-MS epitope characterization for evaluating antibody suitability for ELISA-based in vitro potency testing of vaccines

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00215C, Paper

Alex Listigovers, Liwei He, Lidice Bernardo Reyes, Camille Houy, Luciano Ettorre, Nelson Eng, Jason Szeto, Romain Pizzato, Derek J. Wilson, D. Andrew James, Shaolong Zhu
ELISA requirements: a crosslinked toxoid presents immune epitopes. Antibodies are screened by hydrogen deuterium exchange. Antibodies targeting separated neutralizing epitopes support in vitro potency testing, replacing in vivo.
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Applying systems thinking to analytical system development for managing the antimicrobial resistance crisis

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01182E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Rebecca X. Y. Chen, Rayane Azani, Kayla Elliott, Sarah Jane Payne, R. Stephen Brown, Zhe She
Antimicrobial resistance (AMR) is a global, cross-sectoral crisis spanning clinical, agricultural, and environmental systems. Advances in rapid, standardized detection methods are key to enabling real-time monitoring and informed interventions.
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Simultaneous Quantitation of Structurally Analogous Bile Acid Isomers via Charge-State-Engineered UPLC-MS

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00420B, Paper

Desen Su, Yunyun Zheng, Xiuxian Lin, Ziqiang Chen, Minmin Huang, Qinghua Yao, Yuwu Chi
Ursodeoxycholic, hyodeoxycholic, chenodeoxycholic, and deoxycholic acid are endogenous, dihydroxylated bile acid isomers that share a molecular mass but fulfill specific biological roles. However, their isomeric structures complicate analytical separation, while...
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Upcycling Lemon Peel Waste into Sustainable Bioactive Ingredients.Chemical Characterization and Efficacy Assessment

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00048G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ritamaria Di Lorenzo, Ilaria Neri, Raffaele Raimondo, Daniela D Matteo, Carlo Irace, Maria Grazia Ferraro, Mariavittoria Verrillo, Teresa Ponticorvo, Teresa Di Serio, Sonia Laneri, Lucia Grumetto
The upcycling of agro-industrial by-products emerged as a sustainable strategy to reduce waste, generating high-value bioactive compounds. In this study, exhausted Citrus limon peels-residues obtained after Limoncello production, a typical...
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A portable fiber-optic sensor based on the UiO66–lucigenin complex for chloride ion concentration measurement

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00101G, Paper

Runqi Yao, Jixing Huang, Zelin Gao, Hengbiao Zhang, Li Yang, Dekui Zhang, Tuanjie Che, YuChao Li, Honghan Dong, Xusheng Xia, Ning Wang, Liyun Ding
Detecting the concentration of chloride ions in water and soil is of great significance for understanding chloride behavior in the ocean and monitoring environmental pollutants.
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Ultra-trace electrochemical determination of total arsenic in actual water samples and food matrices using a nano-granular gold–copper modified glassy carbon electrode (NG-AuCu/GCE)

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00044D, Paper

Sadia Yousaf, Usman Naseer, Mehwish Shah, Liufang Chen, Hailong Yan, Qingyun Cai
A glassy carbon electrode is modified with a nano-granular network of gold–copper (NG-AuCu/GCE) for total arsenic determination in actual water and food matrices.
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Toward real-time protein profiling in biofluids using discriminative Raman spectral markers

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00887E, Paper

Kadambari Jandhyala, Priyanka Dey
Simultaneous analysis of multiple proteins in liquid biopsies is essential for accurate disease diagnosis and monitoring yet remains challenging in complex biological matrices when proteins exhibit high structural similarity.
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Lanthanide complex-based dual-modal probes for background-free time-gated luminescence and 19F magnetic resonance detection of hypochlorous acid in acute kidney injury

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00197A, Paper

Shuqi Duan, Qi Liu, Xinyue Zhang, Wenzhu Zhang, Jingli Yuan, Bo Song
A lanthanide complex probe, Ln(SDHH)₃(DPBT) (Ln³⁺ = Eu³⁺, Gd³⁺), as a dual-modal platform for TGL and ¹⁹F MR detection of HClO in acute kidney injury.
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Portable multichannel immunoassay of coxsackievirus A6 using a coordination-engineered iridium-doped ZIF-8 nanozyme

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00297H, Paper

Fangming Zhu, Rongxiu Deng, Xue Liu, Guoliang Dai, Yuyang Zhou
An iridium-doped ZIF-based nanozyme with peroxidase-like activity was developed via a one-pot method to enhance the binding ability between H₂O₂ and doped iridium atoms.
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Quantitative Metabolomics Identifies Prognostic Biomarkers Associated with NSCLC after chemoradiotherapy

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00069J, Paper

Leirui Yuan, Linfang Wu, Mingmin Qian, Chenxi Li, Daquan Wang, Xiang Fang, Shanlin Mao, Di Yang, Minghao Wang, Nan Bi, Yanhua Chen, Luhua Wang, Zeper Abliz
Introduction: The high mortality of non-small cell lung cancer (NSCLC) is influenced by pre-treatment individual variability, yet reliable prognostic biomarkers are lacking, hindering precision therapy.Objectives: This study aimed to identify...
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Application of an Astragalus biochar molecularly imprinted electrochemical sensor for highly sensitive sensing and detection of triazophos in tea

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00251J, Paper

Dongdong Cheng, Jia Li, Xin Wang, Yi Li, Pen Jin, Jun Lin, Meng Li, Ruojia Li, Yongquan Dai, Weicheng Qin, Binlian Jiang, Zegen Wang, Lina Lu, Xiaojun Yang
In this study, a novel electrochemical sensing interface was developed for the detection of triazophos (TAP) in tea.
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Duplex-specific nuclease-assisted isothermal signal amplification coupled with HPLC-UV for simultaneous detection of multiple microRNAs

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00272B, Paper

Haoran Qiu, Jialin Li, Yu Han, Hao Wu, Xin Sun
A DSN coupled HPLC-UV method enables multiplexed miRNA detection in a single reaction with performance comparable to that of stem–loop RT-qPCR.
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A neutral BODIPY molecular rotor photosensitizer for mitochondrial targeting

Analyst, 2026, 151,2161-2165
DOI: 10.1039/D5AN01314C, Communication

Surendra Kumar, Anjani Kumar, Durgendra Yadav, Sathya Prakash Kumarasamy, Vinay Sharma, Roop Shikha Singh
Herein, two novel neutral sulfone-BODIPY-based molecular rotors (SB1 and SB2) have been designed and synthesized, integrating viscosity-responsive turn-on fluorescence with ISC-driven ROS generation for mitochondrial targeting.
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FFSC-based sensors for non-invasive real-time glucose monitoring

Analyst, 2026, 151,2401-2410
DOI: 10.1039/D5AN01287B, Paper

Muthukumara Rajaguru Kattiakara Muni Samy, Abhishek Gudipalli
This study presents the design, modeling, experimental validation of a Fringing Field Sensing Capacitor (FFSC) based sensor for non-invasive real-time glucose monitoring. It is integrated with a notch filter operating within the 0.5 to 1 GHz frequency.
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Enhanced detection of low-surface-charge nanoparticles via pressure regulation in solid-state nanopores

Analyst, 2026, 151,2220-2226
DOI: 10.1039/D6AN00058D, Paper

Tixi He, Yin Zhang
This work uses pressure to enhance the capture rate of low-surface-charge nanoparticles and to discriminate between different charges and sizes.
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Tuning MIP-QCM selectivity for zinc ions via cross-linker/monomer ratio

Analyst, 2026, 151,2227-2234
DOI: 10.1039/D5AN01106J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jialing Song, Charles Jordi Windle, Haoxing Lai, Melvin Zhi Yuan Low, Fun Man Fung, Xuanhao Lin, Sam Fong Yau Li
A Zn²⁺ MIP sensor was developed and optimised for water analysis. Key parameters, specifically the cross-linker/monomer ratio, ensure high selectivity, stability, and rapid response. High recovery in real matrices confirms its environmental utility.
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Nucleic acid aptamer-functionalized magnetic MIL-53(Al)-NH2 for highly selective magnetic dispersion solid-phase extraction of chloramphenicol

Analyst, 2026, 151,2314-2323
DOI: 10.1039/D5AN01025J, Paper

Liangliang Peng, Yao Yao, Meiqi Li, Xingtong Ji, Jinbo Cao, Jiaming Zhang, Fusheng Zhong, Xixiang Yang, Xiaogang Hu
Aptamer-functionalized magnetic MOF (CAP-Apt@MMIL-53(Al)-NH₂) for HPLC-based detection of trace CAP in milk and honey.
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Pinched-flow fractionation-based extracellular vesicle isolation by ExoFAST and its analytical benchmarking with commercial technologies

Analyst, 2026, 151,2177-2189
DOI: 10.1039/D5AN01337B, Paper

Chaithanya Chelakkot, Yanymee N. Guillen-Quispe, Jongjin Jo, Yong Rim Ryu, Jinil Han, Saehyung Lee, Jieun Park, Soo Jin Ryu, Hong Songyoul, Sungha Park, Hun Seok Lee, Young Kee Shin
Comparative analysis of extracellular vesicle isolation by ExoFAST and established methods.
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Study on low temperature enrichment-headspace sampling-proton transfer reaction-mass spectrometry (LTE-HS-PTR-MS) for highly sensitive analysis of trace exhaled VOCs

Analyst, 2026, 151,2290-2298
DOI: 10.1039/D6AN00175K, Paper

Jie Jin, Wei Xu, Ning Zhang, Qi Zhang, Xun Bao, Qu Liang, Qiangling Zhang, Chaoqun Huang, Xue Zou, Chengyin Shen, Yannan Chu
To address detecting low concentration VOCs in high-humidity exhalation, this study developed a highly sensitive technique: low temperature enrichment-headspace sampling-proton transfer reaction-mass spectrometry (LTE-HS-PTR-MS).
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Self-protected circular DNAzyme for integrated enrichment and quantification of small extracellular vesicles

Analyst, 2026, 151,2166-2176
DOI: 10.1039/D5AN01340B, Paper

Qianqian Wu, Yican Li, Ruyan Niu, Xing Wang, Yufang Zhang, Yao Ma, Zhixin Cha, Yao Luo, Xin Cui, Jichun Yang, Zheng Chen, Zhizeng Wang, Xiaohui Chen, Yang Luo
A circular DNA Shield safeguards the DNAzyme core from nuclease degradation. This self-protected DNAzyme walker enables the rapid and simultaneous specific isolation and quantification of sEVs.
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Juniper-based Cu@activated carbon functionalized with ethylenediamine: a green platform for non-enzymatic detection of dopamine

Analyst, 2026, 151,2190-2212
DOI: 10.1039/D5AN01141H, Paper

Afef Dhaffouli, Pedro A. Salazar-Carballo, Soledad Carinelli, Lívia Flório Sgobbi, Adam Slabon, Bruno V. M. Rodrigues
A green sensor based on juniper seed activated carbon functionalized with Cu-NPs and amine groups enables nanomolar dopamine detection.
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Lighting up hypochlorous acid through C(sp2)–H hydroxylation with a solvatochromic organoiridium(III) complex-based probe

Analyst, 2026, 151,2390-2400
DOI: 10.1039/D6AN00002A, Paper

Bhaskar Sen, Jogat Gogoi, Kripamoy Aguan, Snehadrinarayan Khatua
A solvatochromic cyclometalated Ir(III) complex-based probe containing a click-generated ligand is reported for the highly selective and sensitive light-up luminescent detection of HOCl through C(sp²)–H hydroxylation in a mixed aqueous buffer medium.
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Recent progress in wearable electrochemical sensors based on MXene-conductive hydrogels

Analyst, 2026, 151,2135-2160
DOI: 10.1039/D5AN01118C, Tutorial Review

Hanieh Golshahi, Kheibar Dashtian, Rouholah Zare-Dorabei, Kagan Kerman
MXene-based conductive hydrogels (MCHs) have emerged as highly promising materials for next-generation wearable electrochemical sensors, owing to their exceptional electrical conductivity, mechanical flexibility, and biocompatibility.
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Urinary metabolomic characterization of meclofenoxate based on UHPLC-Q exactive HF orbitrap MS technology

Analyst, 2026, 151,2372-2378
DOI: 10.1039/D5AN01344E, Paper

Bing Liu, Wennuo Xu, Tingyuan Zheng, Zhongquan Li, Jingjing Zhao
This study demonstrated significant intergroup differences in the metabolites of urine samples before and after the administration of meclofenoxate and further screened for eight major potential biomarkers.
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Magnetic-aminopropyltriethoxysilane-sulfanilamide: a new functional sorbent for selective preconcentration of sulfonylurea antidiabetic drugs in biological samples

Analyst, 2026, 151,2324-2335
DOI: 10.1039/D5AN01377A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Songül Ulusoy, Şule İrem Altunbaş, Aslıhan Gürbüzer, Ümmügülsüm Polat, Halil İbrahim Ulusoy
A highly selective and sensitive analytical strategy was established for the trace quantification of two oral antidiabetic drugs, gliclazide (GLZ) and glimepiride (GLM).
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MOF-metal nanohybrid-assisted charge transfer amplification for electrochemical biosensing of the MUC1 cancer biomarker

Analyst, 2026, 151,2379-2389
DOI: 10.1039/D6AN00018E, Paper

Sarita Devi, Shivangi Goel, Sonia Rani, Rudolf J. Schneider, Rishika Rohilla, Surbhi Kumari, Nirmal Prabhakar
FTO-OH was modified with FeMOF@PdNR and anisotropic PVP-stabilized PdNRs to form a conducting network. It improved the density of electroactive centres (I*), electron transfer kinetics (K_app, i₀), and provided LOD 0.074 fg mL⁻¹ MUC1.
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A highly sensitive Love-wave surface acoustic wave immunosensor for point-of-care detection of Cyfra21-1 in saliva

Analyst, 2026, 151,2269-2279
DOI: 10.1039/D6AN00023A, Paper

Xiaojing Zhang, Hongyang Guo, Li Sin Wong, Hangming Xiong, Liubing Kong, Li Zhang, Yanjie Hu, Yong Zhou, Hao Wan, Ping Wang
A SAW immunosensor for point-of-care detection of Cyfra21-1 in saliva within 20 min, where Cyfra21-1 is captured by Ab1 immobilized via a SAM, and signal-amplified by AuNP@Ab2, while the reference channel compensates nonspecific and matrix effects.
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Negative selection assisted isolation of a highly selective DNA aptamer for the detection of 17α-ethinylestradiol

Analyst, 2026, 151,2213-2219
DOI: 10.1039/D5AN01374G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nathania Lui, Qiushi Liu, Juewen Liu
Using 17α-ethinylestradiol as a target and 17β-estradiol as a counter target, a highly selective aptamer with nanomolar affinity was obtained for 17α-ethinylestradiol, a synthetic estrogenic compound of significant environmental concern.
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Catalytic effect of conductive dyes for improved analytical performance of an electrochemical sensor for piperine determination in black pepper

Analyst, 2026, 151,2336-2346
DOI: 10.1039/D6AN00068A, Paper

Sanja Mutić, Sandra Petrović, Dalibor Stanković, Jasmina Anojčić
Electropolymerization of murexide (MUX) or bromocresol green (BCG) molecules on a carbon paste electrode (CPE) was utilized to prepare a sensitive, reliable and cost-effective electrochemical sensor for determination of piperine in black pepper.
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A boron-doped diamond interdigital sensor with an alternating excitation strategy for integrated conductivity and free chlorine measurement

Analyst, 2026, 151,2358-2371
DOI: 10.1039/D6AN00030D, Paper

Yujing Xiao, Xiaopeng Chen, Yunzhe Han, Jiawen Yin, Xin Zhang, Yangbo Wu, Qinghui Jin
This study addresses the requirement for precise detection of free chlorine in swimming pool water by proposing and validating an electrochemical sensor based on boron-doped diamond (BDD) electrodes.
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A single fluorescent probe for simultaneous detection of Zn2+, Cd2+, and Pb2+ in industrial wastewater with application in bio-imaging and molecular logic gates

Analyst, 2026, 151,2347-2357
DOI: 10.1039/D5AN01239B, Paper

Chandi Charan Ghosh, Snigdha Roy, Sowmadeep Das, Sanju Das, Ambarish Ray, Partha Pratim Parui
Pb²⁺, which distinguishes the fluorescence of Zn(II)- from Cd(II)-complex, is used to detect Zn²⁺, Cd²⁺, and Pb²⁺ in mixtures.
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Harnessing a UiO-66-NH2/LaFeO3 nanocomposite for the electrochemical sensing of prednisone

Analyst, 2026, 151,2299-2313
DOI: 10.1039/D6AN00008H, Paper

Adrian Ebenezer Paul, Nandhini Panchatcharam, Jerry J. Wu, Ramalinga Viswanathan Mangalaraja, Jegadesan Subbiah, Anandan Sambandam
Achieved highly selective prednisone detection with a detection limit of 0.1 μM via CV and DPV techniques using UiO-66-NH₂/LaFeO₃ composite prepared by an ultrasonic method.
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Fluorescent aptasensor for enrofloxacin detection based on APE1-assisted amplification and CsPbBr3@MSN nanocomposites

Analyst, 2026, 151,2280-2289
DOI: 10.1039/D6AN00085A, Paper

Huanhuan He, Jing Feng, Luna Guo, Weiling Song, Hong Zhou
A fluorescence sensor for ENR detection based on APE1-assisted amplification and the CsPbBr₃@MSN nanocomposites.
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Classification of small specimen uranium ores using LIBS combined with machine learning and deep learning algorithms

Analyst, 2026, 151,2241-2252
DOI: 10.1039/D5AN01326G, Paper

Jingrong Li, Xiaoliang Liu, Min Zhang, Xiangting Meng, Rong Hua, Shaohua Sun, Zuoye Liu, Chunyan Zou, Xiaoyang Guo
Small-specimen uranium ore requires accurate classification for relevant applications. Laser-induced breakdown spectroscopy combined with machine and deep learning models, are explored to enhance its classification.
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An optical fiber crystal violet sensor using a porous ITO membrane coated on an optical fiber surface with UV photon-enhanced sensitivity

Analyst, 2026, 151,2253-2268
DOI: 10.1039/D5AN01156F, Paper

Josiah W. Miller, Shiquan Tao
Indium tin oxide (ITO) is an optically transparent semiconductor used in many optoelectronic devices.
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Improved NMR-based diffusion measurements for inorganic ions

Analyst, 2026, 151,2235-2240
DOI: 10.1039/D5AN01232E, Paper

Maria Clara D. N. G. Leal, Binhan Yu, Tianzhi Wang, Junji Iwahara
The most widely used NMR method to measure diffusion is suboptimal for inorganic ions. A robust and superior alternative is available when strong field gradients (>1000 G/cm) can be used.
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Third-generation nanopore sequencing: advancing real-time pathogen detection and antimicrobial resistance surveillance in food safety applications

Analyst, 2026, 151,2121-2134
DOI: 10.1039/D5AN01028D, Critical Review

Muhammad Nadeem, Aysha Sarfraz Rizvi, Abdul Rahman, Ghulam Murtaza
Foodborne diseases impact 600 million people annually, causing 420 000 deaths and over $110 billion in economic losses.
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Smartphone assisted high-performance fluorescence/colorimetric dual-mode enantioselective identification of glutamic acid in complex samples

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00240D, Paper

Cancan Lu, Chen Liu, Yaning Duan, Tao Yi, Cuiling Ren, Hongli Chen
The synthesized fluorescent/colorimetric dual-mode probe can sensitively detect Glu enantiomers in biological samples. The probe can specifically detect D/L-Glu in a mixture of 19 kinds of amino acids and 16 kinds of ions.
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Selective Detection of Lipophagy with a Highly Specific Lipid Drop-let Probe

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01241D, Paper

Shixiong Wen, Xiaoxue Zou, Jianing Liu, Jiahuai Han, Shoufa Han
Lipophagy, the autophagic degradation of lipid droplets (LDs) by lysosomes, is an important route for maintaining LD homeostasis. Tools for lipophagy detection facilitate research in LD biology. Herein, we report...
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Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00053C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sian Sloan-Dennison, Ben Clark, Kathleen M. Scullion, Fiona Smillie, Stacey Laing, Paul Fineran, Joanne Mair, Cicely Rathmell, Dieter Bingemann, Jonathan Faircloth, David Creasey, Neil C. Shand, Chris J. Weir, James W. Dear, Duncan Graham, Karen Faulds
Lateral flow immunoassays (LFIAs) coupled to surface enhanced Raman scattering (SERS) measurements can produce quantitative outputs with excellent reproducbility over a prolonged period of time.
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A simple photothermal paper-based analytical device using silver nanomaterials for quantitative mercury ion monitoring in drinking water and Wolffia samples

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00094K, Paper

Tapparath Leelasattarathkul, Kawin Khachornsakkul, Pattarawadee Wichaiwong, Wijitar Dungchai
A highly sensitive and cost-effective photothermal-based paper analytical device (PT-PAD) has been developed using silver nanomaterials to monitor Hg²⁺ levels.
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Metabolomics in the wild: research opportunities, challenges, and regulatory potential for effects-based environmental monitoring

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00140H, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Georgia M. Sinclair, Sarah L. Green, Ryan Lester, Katherine J. Jeppe, Steven D. Melvin, Sara M. Long, Oliver A. H. Jones, David J. Beale
Field-based metabolomics detects early biological responses to complex contaminant mixtures in real ecosystems. Integrated with chemistry and ecology, it supports effects-based monitoring and regulatory decision-making.
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Time-domain luminescence lifetime imaging with oxygen sensor particles in the presence of actinic light

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00122J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Georg Schwendt, Michael Kühl
Fast and robust oxygen imaging under photon irradiance levels corresponding to mid-day solar irradiation.
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Environmentally benign synthesis of blue fluorescent graphene quantum dots for nitroaromatic sensing (p-nitroaniline and 2,4,6-trinitrophenol) and their nanophytotoxicity analysis

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00045B, Paper

Krishna Moni Deka, Saikat Das, Rachita Newar, Rajkanya Das, Bappy Sen, Hemen Sarma, Arabinda Baruah
Blue fluorescent graphene quantum dots for nitroaromatic sensing (p-nitroaniline and 2,4,6-trinitrophenol) and analysis of their nanophytotoxicity.
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Disentangling method-induced differences in metabolomics: single- versus dual-phase extraction

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00025H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sehyeon (Erica) Kim, Tao Huan
A systematic LC-MS metabolomics comparison reveals how pipetting, partitioning, and matrix effects drive differences between single- and dual-phase extractions, providing a framework for optimizing metabolite recovery and analytical performance.
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Design of a “turn-on” colorimetric sensor for AChE inhibitors based on the instability of metal–organic frameworks

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00156D, Paper

Jun Zhang, Wenzhu Jiang, Zhiping Xu, Lin Zhang
Illustration of the colorimetric assay based on Cu-BTC with peroxidase-like activity for the AChE inhibitor.
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The infinite-dimensional nature of spectroscopy and why models succeed, fail, and mislead

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00346J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Umberto Michelucci, Francesca Venturini
Machine learning (ML) models have achieved high accuracies in spectroscopic classification, without a clear proof that those models used chemical features. High dimensionality offers a shortcut for models to achieve the performance we observe.
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