RSC - Analyst latest articles

Self-protected circular DNAzyme for integrated enrichment and quantification of small extracellular vesicles

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01340B, Paper

Qianqian Wu, Yican Li, Ruyan Niu, Xing Wang, Yufang Zhang, Yao Ma, Zhixin Cha, Yao Luo, Xin Cui, Jichun Yang, Zheng Chen, Zhizeng Wang, Xiaohui Chen, Yang Luo
A circular DNA Shield safeguards the DNAzyme core from nuclease degradation. This self-protected DNAzyme walker enables the rapid and simultaneous specific isolation and quantification of sEVs.
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Quantification of olaparib in human liver microsomes using an ultra-fast UPLC-MS/MS quantitative approach: in vitro and in silico metabolic stability assessment

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00077K, Paper

Mohamed W. Attwa, Haitham AlRabiah, Adnan A. Kadi
Evaluations using the DEREK software and analyses of in silico WhichP450 results suggest that minor modifications or substitutions within the phthalazin-1-one (52%) and piperazine moieties (24%) account for 76% of olaparib in drug development.
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Microenvironment-mediated oxidative enhancement of conjugated polyelectrolytes for the detection of hydrogen peroxide

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01257K, Paper

Kareem Alhafi, Pierre Karam
The sensitive detection of hydrogen peroxide is important for many applications, including biomedical diagnostics and environmental monitoring.
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Super-lightweight, Low-cost and Wireless Water Quality Monitor for Remote Chlorine-rate Management in Water-circulating Cooling Facilities

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00029K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Masayuki Kawakami, Toshihiro Kasama, TOMOMI SATO, Hidekatsu Tazawa, Daisaku Yano, Madoka Takai, Ryo Miyake
There is a growing demand for the continuous monitoring of residual chlorine for water-circulating cooling facilities to remotely maintain concentrations within an appropriate range. This study aims to develop a...
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A highly sensitive Love-wave surface acoustic wave immunosensor for point-of-care detection of Cyfra21-1 in saliva

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00023A, Paper

Xiaojing Zhang, Hongyang Guo, Li Sin Wong, Hangming Xiong, Liubing Kong, Li Zhang, Yanjie Hu, Yong Zhou, Hao Wan, Ping Wang
A SAW immunosensor for point-of-care detection of Cyfra21-1 in saliva within 20 min, where Cyfra21-1 is captured by Ab1 immobilized via a SAM, and signal-amplified by AuNP@Ab2, while the reference channel compensates nonspecific and matrix effects.
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Fluorescent aptasensor for enrofloxacin detection based on APE1-assisted amplification and CsPbBr3@MSN nanocomposites

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00085A, Paper

Huanhuan He, Jing Feng, Luna Guo, Weiling Song, Hong Zhou
A fluorescence sensor for ENR detection based on APE1-assisted amplification and the CsPbBr₃@MSN nanocomposites.
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Rapid and colorimetric assay for the detection of S. pneumoniae based on hydrogen peroxide release and analysis using color image processing

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01356A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Cagla Celik Yoldas, Nimet Temur, Nilay Ildiz, Pinar Sagiroglu, Mustafa Altay Atalay, Ali Yilmaz, Ersen Gokturk, Ismail Ocsoy
H₂O₂-triggered anthocyanin degradation enables rapid, instrument-light S. pneumoniae screening with objective ΔE image readout.
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A paper-based immunoassay with signal amplification for the sensitive detection of nucleocapsid protein toward the diagnosis of long COVID

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01267H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mônica Duarte da Silva, Ruth Speidel, Ayesha Seth, Hianka J. C. Carvalho, Maria A. Miglino, Abraham K. Badu-Tawiah
Long COVID is characterized by persistent symptoms, including fatigue, cognitive impairment, and respiratory issues, affecting a considerable number of individuals post-infection.
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Sequentially activated fluorescent probes based on a purine scaffold: enabling precise spatiotemporal monitoring of H2O2 and tyrosine hydroxylase in the brainstem NTS during spontaneous hypertension

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00124F, Communication

Yang Yu, Jia-Yi Yao, Xiao-Qi Yu, Kun Li, Kang-Kang Yu
Novel probes as efficient tools for accurate monitoring of H₂O₂/TH accumulation in brainstem NTS during spontaneous hypertension.
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PFAS isomers in aquatic biota: revealing differences in occurrence, bioaccumulation, and biotransformation through isomer-specific analysis

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01246E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mindula K. Wijayahena, Diana S. Aga
Linear and branched PFAS are often grouped together, though they differ in fate, bioaccumulation, and toxicity. Linear PFAS bioaccumulate more in aquatic organisms than branched forms, indicating the need to distinguish isomers during analysis.
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Juniper-Based Cu@Activated Carbon Functionalized with Ethylenediamine: A Green Platform for Non-Enzymatic Detection of Dopamine

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01141H, Paper

Afef Dhaffouli, Pedro Ángel Salazar Carballo, Soledad Carinelli, Livia Florio Sgobbi, Adam Slabon, Bruno V.M. Rodrigues
We report a green and scalable strategy to engineer a next-generation dopamine (DA) sensor using copper-based nanoparticles (NPs) on activated carbon derived from juniper seeds and functionalized with ethylenediamine (Cu@AC-CONH-CH2CH2-NH2)....
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Heterojunction-engineered two-dimensional Ti3C2–CoFe2O4 nanozyme with oxidase-like activity for SERS detection of glutathione in human serum

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00055J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Huiqi Zhu, Ying Chen, Weiqing Yang, Zunxiang Zeng, Yuling Hu, Ji Zhang
A two-dimensional Ti₃C₂–CoFe₂O₄ heterojunction nanozyme serves as both a high-efficiency oxidase-like catalyst and a SERS substrate for the label-free and sensitive detection of glutathione in clinical serum samples.
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Novel H2 colourimetric indicator for screening the activity of H2-generating bacteria and measuring their total viable count (TVC)

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01221J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lauren McDonnell, Christopher O'Rourke, Michaella Watson, Andrew Mills
Reversible, colourimetric, H₂ indicator (blue to colourless) for monitoring dissolved H₂ and, under controlled conditions, for measuring the total viable count, TVC, units: colony forming, units (CFU) mL⁻¹, of H₂-generating bacteria.
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A portable electrochemical platform for biorecognition-free detection of ochratoxin A and ascorbic acid for food safety and quality monitoring

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00992H, Paper

Brateen Datta, Raghavv Raghavender Suresh, Gorachand Dutta
Simultaneous electrochemical detection of ochratoxin-A and ascorbic acid on the TeO₂–NiO-modified screen-printed paper electrode surface for on-site application.
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Shielded loop-mediated catalytic hairpin assembly for the specific detection of microRNA

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00955C, Paper

Jiani Wang, Fuxian Ge, Jing Wang, Di Zhang, Miran Tang
MicroRNAs (miRNAs) are highly promising biomarkers, especially in the diagnosis, prognosis and therapeutic monitoring of diseases such as cancer.
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Molecular Imprinting of Aptamer/Carbamazepine Complexes for the Development of an Optical Nanosensor

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01268F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Iqra Nosheen Salim, Ellie Richards, Jon Ashley
Monitoring anti-seizure medications (ASMs) such as carbamazepine is important to ensure that the correct dosage is given to patients which provides the maximum therapeutic effect. However, therapeutic windows for carbamazepine...
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Lighting Up Hypochlorous Acid through C(sp2)-H Hydroxylation with a Solvatochromic Organoiridium(III) Complex-based Probe

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00002A, Paper

Snehadrinarayan Khatua, Bhaskar Sen, Jogat Gogoi, Kripamoy Aguan
Herein, we report the highly selective detection of the reactive oxygen species hypochlorous acid (HOCl) using a solvatochromic cyclometalated Ir(III) complex through a unique C(sp2)-H hydroxylation mechanism. The complex, Ir-1,...
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Biosensing technologies for the detection of chemical and biological warfare agents in CBRN environments

Analyst, 2026, 151,1211-1219
DOI: 10.1039/D5AN01272D, Minireview

Zehra Tuğçe Kurt, Muhammed Erkek, Nilay Bereli, Adil Denizli
Advanced biosensing platforms provide rapid, sensitive, and selective detection of chemical and biological warfare agents in CBRN environments, enabling real-time monitoring and early threat warning.
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A highly-efficient isothermal nano-detection platform coupling CRISPR/Cas technology for detection of circRNA

Analyst, 2026, 151,1304-1309
DOI: 10.1039/D6AN00107F, Communication

Kexin Sun, Haizhen Wu
A nano-detection platform for TNBC biomarker circRNA based on the CRISPR/Cas system and isothermal amplification strategy.
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Deep eutectic solvents in molecularly imprinted materials: a comprehensive review of functional roles and recent advances

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01278C, Critical Review

Dongdong Cheng, Xin Wang, Jia Li, Yongquan Dai, Pen Jin, Yi Li, Lina Lu, Xingping Luo, Jun Lin, Zegen Wang, Binlian Jiang, Xiaodong Wei, Zhijun Wang, Shuo Feng
This review illustrates the construction of a deep eutectic solvent (HBA & donor) and its use in synthesizing molecularly imprinted polymers via polymerization, with HBAs participating in imprinting target molecules.
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Carbon dot–MOF composites for cancer biomarker detection: an emerging research frontier

Analyst, 2026, 151,1234-1260
DOI: 10.1039/D5AN00896D, Critical Review

Adedibu C. Tella, Anthony O. Oyediran, Adetola C. Oladipo, Deborah Josiah, Oluwasegun A. Osatuyi, Tolulope M. Eluyera, Victor U. Ugwuanyi, Hadley S. Clayton, Margaret D. Olawale, Gift Mehlana, Oluwatobi S. Oluwafemi
Application of CD@MOF composites for biomarker sensing and integration for point-of-care diagnosis.
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Infrared microscopy of the biochemistry and metabolism in single living eukaryotic cells

Analyst, 2026, 151,1220-1233
DOI: 10.1039/D5AN01213A, Critical Review

Luca Quaroni
Infrared microscopy has evolved into a technique capable of quantitative measurements of biochemical reactions in single living cells.
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Initial testing procedure based on microextraction followed by LC-HRMS analysis to determine 107 xenobiotics and their metabolites in serum/plasma

Analyst, 2026, 151,1477-1494
DOI: 10.1039/D5AN01329A, Paper

Monica Mazzarino, Koen Deventer, Laurie De Wilde, Kris Roels, Peter Van Eenoo
A simple and sensitive microextraction protocol based on the use of unmodified cellulose was developed for the simultaneous extraction of 107 prohibited compounds and their metabolites from 20 µL of serum and plasma.
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Characterizing microscopic calcification deposits on acrylic intraocular lenses

Analyst, 2026, 151,1467-1476
DOI: 10.1039/D5AN00999E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Cassandra L. Ward, S. Sameera Perera, Zhi Mei, Bing X. Ross, Manisha De Alwis Goonatilleke, Mahdi Ayoubi, Yao Xiao, Andrew P. Ault, Judy A. Westrick, Thomas H. Linz, Xihui Lin
Characterizing crystallized deposits on intraocular lenses is challenging due to the small, curved sample. Powder X-ray diffraction, Raman, XPS, and SEM/EDS collectively determined that lens crystals were composed of substituted hydroxyapatite.
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Förster resonance energy transfer-based anion-responsive nanoemulsion optodes: the importance of fluorescent dye liquid lipophilicity and ionophore–dye interaction for stable and background-free anion response

Analyst, 2026, 151,1310-1316
DOI: 10.1039/D5AN01097G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Daiki Matsumoto, Kenji Sueyoshi, Tatsuro Endo, Hideaki Hisamoto
A FRET-based nano-oil droplet anion optode incorporating a highly hydrophobic dye liquid and an anion ionophore achieved a stable, background-free response with about 10-fold higher sensitivity than conventional methods.
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An oxidative cleavage-based HCR-CRISPR/Cas12a biosensor for highly sensitive detection of hypochlorous acid

Analyst, 2026, 151,1317-1324
DOI: 10.1039/D5AN01299F, Paper

Xin Liu, Xiangyue Wang, Shaoying He, Mingxi Li, Chunhua Lu, Chao Xing
An oxidative cleavage-based HCR-CRISPR/Cas12a biosensor was constructed for HClO detection.
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Comparative studies of conventional and AI methods for wastewater treatment in the sugar, food, textile, and pharmaceutical industries: a review

Analyst, 2026, 151,1281-1303
DOI: 10.1039/D5AN00975H, Critical Review

Shagufta Jabin, Ritu Bir, Sadiqa Abbas, Jyoti Chawla, Anisha, Sapana Jadoun
The use of traditional methodologies in combination with artificial intelligence (AI) has attracted much interest for the treatment of industrial wastewater in different sectors, such as food, sugar, textiles, and pharmaceuticals.
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Investigating the existing analytical methods deployed for leptospirosis detection and diagnostics

Analyst, 2026, 151,1261-1280
DOI: 10.1039/D6AN00005C, Critical Review

Embar Prasanna Kannan, Prasanth Venkatachalam, Judy Gopal, Nazim Hasan, Manikandan Muthu
Analytical Palette available for Leptospirosis detection and future scope.
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Untargeted mass spectrometry to investigate ocean acidification in Cancer borealis using optimized metabolite extraction methods

Analyst, 2026, 151,1332-1341
DOI: 10.1039/D5AN00788G, Paper

Yunxiao Yao, Olga Riusech, Shuling Xu, Lingjun Li
Untargeted metabolomics reveals dynamic metabolic responses of Jonah crabs to ocean acidification, highlighting the utility of isopropanol extraction and the need for improved annotation of marine metabolites.
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Thermodynamic and modeling insights of DNA molecular beacons with dual target binding to design for tunable fluorescent outputs

Analyst, 2026, 151,1420-1435
DOI: 10.1039/D5AN01208B, Paper

Esther E. Stopps, Stephanie E. McCalla
Multi-site molecular beacons (MBs) offer a versatile platform for detecting specific nucleic acid targets based on the relative proximity of fluorophore and quencher molecules.
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Integrated microfluidic device for rapid and accurate point-of-care detection of high-risk HPV16 and HPV18

Analyst, 2026, 151,1371-1386
DOI: 10.1039/D5AN01244A, Paper

Natish Kumar, Monika Kumari, Devtulya Chander, Sandeep Dogra, Asha Chaubey, Ravi Kumar Arun
Integrated microfluidic LAMP-LFA platform for on-chip HPV nucleic acid extraction, amplification, and lateral-flow detection.
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CRISPR/Cas13a-induced self-priming cyclic amplification enables liquid biopsy of exosomal circular RNA in non-small cell lung cancer

Analyst, 2026, 151,1413-1419
DOI: 10.1039/D5AN01345C, Paper

Xiaodan Zhu, Guomin Gu, Yanli Shen, Mihray Abdurazik, Gang Sun
The precise and reliable identification of circular RNA (circRNA) is essential for both biological studies and clinical diagnostics of non-small cell lung cancer (NSCLC), especially the exosomal circRNA.
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In situ synthesis of gold-core silver-shell nanoparticles on bacterial cellulose for SERS detection of micro- and nanoplastic particles in vegetables

Analyst, 2026, 151,1357-1370
DOI: 10.1039/D5AN01043H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Seyedehalaleh Kousheh, Azlin Mustapha, Mengshi Lin
Micro- and nanoplastic particles (MNPs) are ubiquitous environmental contaminants, raising significant concerns due to their potential health risks.
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Selective thin film microextraction of naproxen from biological and environmental matrices utilizing chitosan-derived bio-imprinted polymer with fluorescence detection

Analyst, 2026, 151,1444-1456
DOI: 10.1039/D5AN00991J, Paper

Zahra Ayazi, Samira Pashayi Sarnaghi, Mays Ali Hassooni Al-najafi
This study presents the selective isolation of naproxen from complex matrices through thin film microextraction using a chitosan-derived molecularly imprinted polymer thin film, followed by quantification utilizing fluorescence spectroscopy.
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An anti-interference near-infrared SERS tag-aptamer sensor for rapid detection of Staphylococcus aureus in complex matrices

Analyst, 2026, 151,1495-1506
DOI: 10.1039/D5AN01324K, Paper

Rui Zhao, Qishuo Wang, Yunqing Wang, Rongchao Mei, Xiaoyan Wang, Lingxin Chen
We report a near-infrared SERS sensor with superior anti-interference performance, which is accomplished by encapsulating SERS tags into a carboxylated polystyrene shell and covalently conjugating them to a target-specific aptamer.
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A reusable fluorescent biosensor based on a morphology-controlled ZIF-8⊃FAM-DNA film

Analyst, 2026, 151,1457-1466
DOI: 10.1039/D6AN00017G, Paper

Xiaohu Wang, Dongjun Ren, Yangyi Liu, Yunqing Lu, Jin Wang
As a promising porous material, zeolitic imidazolate framework-8 (ZIF-8) exhibits significant application potential in biosensing.
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A synergistic bimetallic MOF/MWCNT nanocomposite for sensitive electrochemical detection of baicalin

Analyst, 2026, 151,1436-1443
DOI: 10.1039/D5AN01276G, Paper

Yijie Zhang, Yongxin Tao, Shan Li, Yong Qin, Jinmin Wang
The ZnNi-MOF@MWCNT sensor, through the synergistic effect of Ni, MWCNTs and the Zn-MOF, achieves highly efficient and selective detection of Bn and demonstrates excellent performance and application potential in actual serum samples.
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An “off–on” electrochemiluminescence biosensor based on CRISPR-Cas12a for ultrasensitive determination of aflatoxin B1

Analyst, 2026, 151,1325-1331
DOI: 10.1039/D5AN01369K, Paper

Zhi-Hong Xu, Xiao Hu, Xin Weng, Ruo-Mei Lin, Wen Xu, Li-Shuang Yu, Hang Gao
An aggregation-induced electrochemiluminescence sensor integrated CRISPR-Cas12a system is firstly reported for the detection of aflatoxin B1 (AFB1), demonstrating excellent analysis performance.
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Temporal SERS quantification and the chemometric monitoring of amikacin release in blood serum from a stimuli-responsive drug carrier: kinetics modeling and in-vitro pharmacodynamic evaluation

Analyst, 2026, 151,1387-1405
DOI: 10.1039/D5AN01153A, Paper

Anfal Fatima, Nasir Mehmood, Ali Akbar, Abdul Naman, Mohammed Alissa, Ghadah S. Abusalim, Adil Abalkhail, Minseok Kim
The controlled delivery of antibiotics from stimuli-responsive hydrogels is a promising approach, although controlled release kinetics and pharmacodynamic (PD) outcomes are very challenging to measure accurately.
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Study on temperature-responsive characteristics of reactant ions in corona discharge ion mobility spectrometry

Analyst, 2026, 151,1406-1412
DOI: 10.1039/D5AN01135C, Paper

Jie Peng, Jingxiong Yu, Changwu Dong, Yihuang Jiang, Hui Xu, Hongtao Liu, Yuan Qian, Zejie Fei
Corona discharge ion mobility spectrometry was used to show the relationship between temperature and hydrated cluster ions. Experiments and calculations revealed temperature-dependent patterns in the stability of ion hydration structures in air.
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Flow solitons of supermolecular complex DEAE-dextran-MMA copolymer/small noncoding RNAs for epigenetic change from cancer to normal cells in TME

Analyst, 2026, 151,1342-1356
DOI: 10.1039/D5AN00375J, Paper

Oxana V. Klimenko, Rui-Cheng Ji, Masayasu Onishi, Masaaki Mizuno, Naoji Kubota, Yuki Eshita, Yasuhiko Onishi
DDMC (DEAE-dextran-MMA copolymer)/sncRNAs (a-miR-155, piR-30074, and miR-125b) complex completely cured mice with virus-induced sarcoma after cellular reprogramming treatment, transforming cancer cells into normal cells.
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Recent Progress in Wearable Electrochemical Sensors Based on MXene-Conductive Hydrogels

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01118C, Tutorial Review

Hanieh Golshahi, Kheibar Dashtian, Rouholah Zare-Dorabei, Kagan Kerman
MXene-based conductive hydrogels (MCHs) have emerged as highly promising materials for next-generation wearable electrochemical sensors, owing to their exceptional electrical conductivity, mechanical flexibility, and biocompatibility. This review provides a comprehensive...
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Development of advanced voltammetric method for telmisartan and study of oxidation mechanism on boron-doped diamond electrode

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00034G, Paper

Gustavo Fix, Ana Heloísa Fonseca Ayala, Carla Cristina Perez, Elen Romão Sartori
A boron-doped diamond electrode was employed to develop a voltammetric method for telmisartan determination. The method was validated and applied in real samples. Electrochemistry coupled with NMR identified the oxidation product.
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Continuous monitoring of glutamate using electroactive templated polymers as synthetic molecular receptors

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01088H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Samin Motallebzadeh, Leila Ahmadian-Alam, Masoumeh Bahrami, Arturo Andrade, Edward Song
Electroactive and target-templated polymers can be used as selective bioreceptors for the continuous monitoring of non-electroactive species such as L-glutamate.
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Chemical reaction-enabled lipidomics: from sensitive structural analysis to biomedical applications

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01334H, Critical Review

Qirui Yu, Xiaoxiao Ma
Diverse chemical derivatization approaches for enhanced analysis in lipidomics.
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A direct comparison of antibody and nanoMIP binding affinities to a protein target using surface plasmon resonance and electrochemical techniques: a haemoglobin model

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01205H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Andrei N. Stephen, Barbara V. Boldrin, Subrayal M. Reddy
NanoMIPs or antibodies are immobilised on electrochemical and SPR chips for electrochemical and optical biosensing of a target protein.
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Urinary Metabolomic Characterization of Meclofenoxate Based on UHPLC-Q Exactive HF Orbitrap MS Technology

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01344E, Paper

Bing Liu, Wennuo Xu, Tingyuan Zheng, Quan Zhong Li, Jingjing Zhao
To investigate the characteristics of changes in human urine metabolites of meclofenoxate by using metabolomics technology based on ultra performance liquid chromatography-Q Exactive HF Orbitrap mass spectrometry (UHPLC-Q Exactive HF...
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Magnetic-aminopropyltriethoxysilane-sulfanilamide: A New Functional Sorbent for Selective Preconcentration of Sulfonylurea Antidiabetic Drugs in Biological Samples

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01377A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Songül Ulusoy, Şule İrem Altunbaş, Aslıhan Gürbüzer, Ümmügülsüm Polat, Halil Ibrahim Ulusoy
A highly selective and sensitive analytical strategy was established for the trace quantification of two oral antidiabetic drugs, gliclazide (GLZ) and glimepiride (GLM). The procedure integrates magnetic solid-phase extraction (MSPE)...
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MOF-metal nanohybrid-assisted charge transfer amplification for electrochemical biosensing of MUC1 Cancer Biomarker

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00018E, Paper

Sarita Devi, Shivangi Goel, Sonia Rani, Rudolf J. Schneider, Rishika Rohilla, Surbhi Kumari, Nirmal Prabhakar
Cancer underscores the severity of a disease characterized by high mortality and complex pathophysiology; however, its early and accurate diagnosis remains insufficient. Conventional diagnostic approaches often fall short, particularly in...
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Recent developments in micro- and nanofluidic catalytic reactors utilizing ultra-small spaces

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01253H, Tutorial Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ben-Yuan Zhang, Koki Yamamoto, Po-Yen Chen, Kyojiro Morikawa
Contributions from microfluidics and nanofluidics have greatly advanced the fields of chemistry and biochemistry, particularly in chemical reactions and biochemical reactions.
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Negative selection assisted isolation of a highly selective DNA aptamer for the detection of 17α-ethinylestradiol

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01374G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nathania Lui, Qiushi Liu, Juewen Liu
Estrogenic compounds, including both natural estrogens such as estrone (E1), 17β estradiol (E2), and synthetic 17α ethinylestradiol (EE2), are widely recognized for their endocrine disrupting effects in the environment. EE2...
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Catalytic effect of conductive dyes for an improved analytical performance of electrochemical sensor for piperine determination in black pepper

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00068A, Paper

Sanja Mutić, Sandra Petrović, Dalibor M Stanković, Jasmina Anojčić
The electrocatalytic properties of anionic dye-based sensors were demonstrated by their strong influence on the oxidation signal of piperine (PIP), a widely used alkaloid usually found in food and pharmaceutical...
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DNA molecular electronics - from molecular devices to quantum sequencing

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01107H, Critical Review

Yiqun Wu, Aoxing Sun, Daifen Yu, Lei Yu
The field of DNA molecular electronics, driven by DNA's unique molecular structure and inherent electrical properties, has evolved from fundamental charge transport studies into a multidisciplinary domain that bridges biophysics,...
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Boron-doped Diamond Interdigital Sensor with Alternating Excitation Strategy for Integrated Conductivity and Free Chlorine Measurement

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00030D, Paper

Yujing Xiao, Xiaopeng Chen, Yunzhe Han, Jiawen Yin, Xin Zhang, Yangbo Wu, Qinghui Jin
Real-time free chlorine measurement through wearable-integrated sensors is critical for swimmer safety. However, existing sensors face reliability challenges for wearable integration due to excessive bulk, insufficient stability, and accuracy degradation...
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A single fluorescent probe for simultaneous detection of Zn2+, Cd2+, and Pb2+ in industrial wastewater with application in bio-imaging and molecular logic gates

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01239B, Paper

Chandicharan Ghosh, Snigdha Roy, Sowmadeep Das, Sanju Das, Ambarish Ray, Partha Pratim Parui
Detecting multiple metal ions, especially those from the same periodic group, is quite challenging with a single fluorophore-based sensing method because of their similar chemical properties. We introduce a unique...
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Comparative performance of tristimulus and color appearance models in low-cost smartphone digital colorimetry for soil CO2 detection

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01190F, Paper

Chairul Ichsan, Khoirun Nisa, Siti Rodiah, M. Mahfudz Fauzi Syamsuri
This study demonstrates that the CAM16UCS color appearance model significantly outperforms traditional tristimulus spaces in smartphone-based soil CO₂ colorimetry, enhancing detection accuracy and sensitivity.
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Raman spectroscopic monitoring of multiproduct chemical reaction kinetics; the case of ester hydrolysis

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01055A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Muhammed Kashif, Mark E. Keating, Hugh J. Byrne
Seeded MCR-ALS with optimized seeding weights enhances spectral unmixing by mitigating rank deficiency issues, yielding reliable concentration profiles, reducing residual errors and enhancing kinetic interpretation.
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Proton transfer reagent cations for ion–ion charge state manipulation of high mass negatively-charged analytes in an electrodynamic ion trap

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01354B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Nicholas R. Ellin, Boukar K. S. Faye, Seth A. Horn, Alexander M. Koers, Scott A. McLuckey
This work summarizes the criteria for a useful reagent for ion/ion proton transfer in an electrodynamic ion trap with specific emphasis on proton transfer to high mass multiply-charged analyte ions.
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Selective fluorescence detection of hydrogen sulfide in the brain microdialysate using an ESIPT-activated probe

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01258A, Paper

Qian Wang, Cong Luo, Jingyi Tang, Zhaolun Duan, Hui Pan, Huihui Wang, Haoyue Xiang, Hui Gu
Hydrogen sulfide (H₂S) has emerged as a key neuromodulator in the central nervous system, yet its accurate quantification in the brain system remains challenging due to strong interference from endogenous thiols and other sulfur-containing species.
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Versatile polymeric membrane ion-selective electrodes based on cellulose triacetate

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01364J, Paper

Lu Liu, Shusheng Liu, Rongning Liang, Wei Qin
For the first time, the versatile properties of the proposed cellulose triacetate-based potentiometric sensors in terms of biocompatibility, biodegradability and easy surface functionalization and construction of new biosensors are illustrated.
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Microplastic detection and recognition system enabled by a triboelectric nanogenerator and machine learning techniques

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00014B, Paper

Peiyin Liu, Wei Long, Zhijie Zhang, Bin Li, Xiaolan Jia
A simple and rapid detection and identification device for microplastics present in water bodies, based on the combination of liquid–solid contact electrification and machine learning algorithms, achieves high-accuracy detection of microplastics.
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A dual-responsive fluorescence aptasensor for simultaneous detection of antibiotics and construction of molecular logic gates

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01366F, Paper

Junbo Hu, Haonan Xu, Pengfei Sun, Yanqin Huang, Xingfen Liu, Quli Fan
A dual-responsive fluorescence aptasensor was established for rapid, sensitive, simultaneous, and intelligent detection of antibiotics.
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Harnessing UiO-66-NH2/LaFeO3 nanocomposite for electrochemical sensing of prednisone

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00008H, Paper

Adrian Ebenazer Paul, Nandhini Panchatcharam, Jerry Wu, Mangalaraja RV, Jegadesan Subbiah, Sambandam Anandan
Prednisone is a synthetic corticosteroid that mimics cortisol by maintaining blood pressure, the immune system, and inflammatory processes. Its widespread presence in biological systems underscores its involvement in various physiological...
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Digital fluorescent pH probes: polymer-based design, fluorescence response, mechanism, functional tuning and application to logic operation in live cells

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01187F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Seiichi Uchiyama, Eiko Hamada, Masaharu Takarada, Kohki Okabe
We developed polymers that exhibit digital-type fluorescence responses to pH variations in aqueous solution and applied them to intracellular logic operations.
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Recent advances in microneedle-based electrochemical biosensors for monitoring biomarkers in interstitial fluid

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01250C, Minireview

Renqiang Yuan, Xiaoxin Ma, Guda Zou, Guohuang Zhou, Jia Liu, Wei Li, Yixin Xu, Shao Su, Lianhui Wang
Taking advantage of painless skin penetration, rapid response, high sensitivity and seamless integration with portable/wireless devices, microneedle-based electrochemical biosensors can monitor a wide range of biomarkers in the interstitial fluid.
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An optical fiber crystal violet sensor using a porous ITO membrane coated on an optical fiber surface with UV photon-enhanced sensitivity

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01156F, Paper

Josiah W. Miller, Shiquan Tao
Indium tin oxide (ITO) is an optically transparent semiconductor used in many optoelectronic devices.
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A dual-modal 19F MRI/18F PET approach using sultone-derived chemical tags

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01102G, Paper

Amaury Guillou, Nicolas Joudiou, Alice Fortin, Fabienne Gourand, Lionel Mignion, Bénédicte F. Jordan, Dominique Cahard, Cécile Perrio
The sultone-based chemical strategy was successfully applied to develop sulfo tags containing a polyfluorinated pentaerythritol scaffoldend with well-defined biocompatible properties, enabling ¹⁹F MRI and also true bimodal ¹⁸F PET/¹⁹F MRI imaging.
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Targeted screening of natural thrombin inhibitors from herbal extracts using an enzyme-immobilized microfluidic reactor

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01290B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xian-Na Wang, Ji Zhang, Yahui Song, Rui-Ping Song, Weiwei Tang, Bin Li
A microfluidic chip-based enzyme-immobilized microfluidic reactor (EIMR) has been developed for in vitro screening of potential thrombin inhibitors from herbal extracts.
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Studying the evolutionary potential of ancestral aryl sulfatases in the alkaline phosphatase family with droplet microfluidics

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00865D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Bernard D. G. Eenink, Josephin M. Holstein, Magdalena Heberlein, Carina Dilkaute, Joachim Jose, Florian Hollfelder, Bert van Loo, Erich Bornberg-Bauer, Tomasz S. Kaminski, Andreas Lange
Extant and reconstructed ancestral aryl sulfatases were compared using directed evolution. Mutant libraries were screened using microfluidic droplet sorting, the activity of each variant was measured and improved variants were recovered.
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Integration of Raman tweezers and machine learning for label-free single-cell characterization of endometriosis cells

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01076D, Paper

Nguyen Dinh Hien, Asaduzzaman, Ajitesh Dhal, Bashir Danmahawayi Zubairu, Chang-I Chen, J. Timothy Qiu, Zhao-Chi Chen, Tzu-Sen Yang
Raman tweezers and explainable machine learning enable label-free single-cell profiling of endometriosis, revealing unique biochemical signatures for accurate diagnosis.
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Electrochemical Evaluation of Plant Extracts as Potential Antidotes for Acetaminophen Poisoning

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01322D, Paper

Rahim Babereh, Hassan Shayani-jam, Mohammad Reza Yaftian, Bahaman Farajmand, Mohammad Hassan Moeini, Shadi Moeinifar
Acetaminophen, a widely used analgesic, causes severe liver damage in overdose due to the N-acetyl-p-benzoquinoneimine (NAPQI), a toxic metabolic intermediate. Current antidotes, like N-acetylcysteine (NAC), are effective but costly and...
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Selective electrochemical discrimination of 3′ isomiRs differing by two nucleotides

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01292A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Julio Ojeda, Nicholas Bruno, Karen Cover, Wen Cai Zhang, Karin Chumbimuni-Torres
MicroRNAs and isomiRs are promising biomarkers for the detection of diseases such as cancers, but distinguishing the highly similar microRNA sequences between these remains challenging.
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Optical photothermal infrared spectroscopic assessment of microplastics in tissue models and non-digested human tissue sections

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00241A, Paper

Azita HassanMazandarani, John M. Masterson, William Querido, Andrzej Steplewski, Yi Zhang, Carissa Huynh, Maurice M. Garcia, Andrzej Fertala, Nancy Pleshko
A novel O-PTIR method detects and identifies microplastics directly in non-digested human tissue and tissue phantom sections, preserving spatial context and chemical specificity—eliminating the need for harsh digestion protocols.
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Graphdiyne-assisted LDI-MS for rapid, non-invasive urine metabolomic profiling in tuberculosis screening

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01054C, Paper

Yile Yu, Xiaoyan Zhong, Xi Yu, Jinhang Li, Huihui Liu, Xin Liu, Lixia Jiang, Zongxiu Nie
GD-assisted LDI-TOF MS of urine with PCA and machine learning distinguished active TB from controls. Altered energy, nucleotide, and amino-acid metabolism suggest non-invasive biomarkers and mechanistic signatures for TB screening.
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Differences in α-synuclein conformational states in physiologically relevant pH/Na+ concentrations and ammonium acetate solutions unveiled by native mass spectrometry

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01336D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Erick G. Báez Bolívar, Jessica S. Fortin, Taiwo A. Ademoye, Scott A. McLuckey
Native MS implemented with theta emitters was used to demonstrate differences in conformational states of wild-type and mutant α-synuclein dissolved at physiologically relevant pH and Na⁺ concentrations compared to solutions of ammonium acetate.
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Classification of small specimen uranium ores using LIBS combined with machine learning and deep learning algorithms

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01326G, Paper

Jingrong Li, Xiaoliang Liu, Min Zhang, Xiangting Meng, Rong Hua, Shaohua Sun, Zuoye Liu, Chunyan Zou, Xiaoyang Guo
Small-specimen uranium ore requires accurate classification for relevant applications. Laser-induced breakdown spectroscopy combined with machine and deep learning models, are explored to enhance its classification.
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Magnetic molecularly imprinted polymer-assisted target enrichment for the fluorescence detection of chloramphenicol in water

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00075D, Paper

Zan Long, Jiajun Guo, Xiaofeng Liu, Caicheng Long, Peng Zhang, Bo Feng, Taiping Qing
The abuse of antibiotics has induced various environmental problems and poses a threat to human health and life.
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Structure-adaptive dual-function poly-T sequences enable a homogeneous label-free colorimetric sensing platform

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01335F, Paper

Shao-Yu Sun, Yi Song, An-Qi Xiao, Xin-Yan Zhang, Xu-Xia Yan, Hui-Dong Qiu, Qian-Yu Zhou
A colorimetric sensing platform for melamine detection based on structure-adaptive dual-function poly-T sequences.
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Targeted serum metabolomics reveals alterations in amino acid and neurotransmitter pathways in Parkinson's disease

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00961H, Paper

Jiaxin Yang, Dong Wu, Zhiwei Wang, Zhijing Zhang, Xiaowen Zheng, Sheng Wang, Fen Huang, Shuai Song, Qunlin Zhang
Targeted UPLC-MS/MS shows widespread serum amino acid and neurotransmitter shifts in Parkinson's disease: Gly/Ser drops, Pro rises, and arginine biosynthesis plus glyoxylate and Gly/Ser/Thr metabolism emerge as linked pathways of progression.
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Exploring the feasibility of near-infrared spectroscopy and machine learning for detecting cardiovascular diseases and diabetes mellitus in fingernails

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01061F, Paper

Megan Wilson, Dhiya Al-Jumeily, Jason Birkett, Iftikhar Khan, Ismail Abbas, Matthew Harper, Sulaf Assi
Disease-related spectral regions attributed to glycated products were captured through near-infrared spectroscopy and when paired with machine learning classification models, produced high levels of predictive accuracy.
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Correction: Light-activated nanocomposite thin sheet for high throughput contactless biomolecular delivery into hard-to-transfect cells

Analyst, 2026, 151,1195-1198
DOI: 10.1039/D5AN90082D, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Hima Harshan Padma, Donia Dominic, Kavitha Illath, Srabani Kar, Tuhin Subhra Santra
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One-pot ligation-PCR for universal RNA biomarker detection

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01203A, Paper

Jinding Liu, Zhixin Xie, Nini Li, Jiajia Li, Minghua Zhang, Yongqiang Cheng, Jiangyan Zhang
Glyoxal-caged primers stay inactive during ligation and become heat-activated for PCR, enabling sequential ligation and amplification in one pot for highly specific RNA detection.
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Resolving the chemical space: a legacy of recording separation science and innovation in Analyst

Analyst, 2026, 151,937-938
DOI: 10.1039/D5AN90086G, Editorial

Leon P. Barron, Brett Paull, Lihua Zhang
The Guest Editors introduce this Analyst 150^th anniversary themed issue on separation science.
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Design, preparation of microneedles and their applications in medical diagnosis and cosmetic regeneration

Analyst, 2026, 151,949-972
DOI: 10.1039/D5AN01095K, Minireview

Shanqi Bao, Huanhuan Shi, Weizheng Xu, Zidong Zhou, Shijie Qu, Xinyi Wang, Ziwen Cheng, Chen Huang
This review covers the classification and core traits of polymer-based microneedles, their mainstream preparation technologies, their applications in transdermal drug delivery, vaccine administration and skin disease treatment, and insights for overcoming clinical translation bottlenecks.
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Vibrational spectroscopy for rapid profiling of vancomycin susceptibility in Enterococci

Analyst, 2026, 151,1008-1013
DOI: 10.1039/D5AN01068C, Communication

Ava Rossetti, Xenia Kostoulias, Magdalena Giergiel, Jhih-Hang Jiang, Anton Y. Peleg, Kamila Kochan
ATR-FTIR spectroscopy detects early chemical responses to vancomycin, enabling rapid differentiation of vancomycin-susceptible and -resistant enterococci. This work establishes a label-free platform for accurate antimicrobial susceptibility testing.
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MXene-based fluorescent aptasensors: advances and prospects in diagnostics and environmental monitoring

Analyst, 2026, 151,973-990
DOI: 10.1039/D5AN00945F, Minireview

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Rajapriya Govindaraju, Jongsung Kim
MXene-based fluorescent aptasensors for diagnostics and environmental monitoring.
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Ambient ionization strategies for the characterization of microbial systems via mass spectrometry

Analyst, 2026, 151,939-948
DOI: 10.1039/D5AN01214G, Minireview

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Hawkins S. Shepard, Jody C. May, John A. McLean
This minireview focuses on the most important developments in the field of ambient ionization mass spectrometry applications to microbial samples reported in the last five years.
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Quantification of buparlisib in human liver microsomes employing an ultra-fast, sensitive UPLC-MS/MS method: in vitro and in silico metabolic stability evaluation

Analyst, 2026, 151,1058-1070
DOI: 10.1039/D5AN01155H, Paper

Mohamed W. Attwa, Haitham AlRabiah, Ali S. Abdelhameed, Adnan A. Kadi
Buparlisib exhibited a moderate extraction ratio, with a Cl_int of 32.24 mL min⁻¹ kg⁻¹ and a t_1/2 of 25.15 min. Small changes of the 2-aminopyridine (58%) and morpholine (42%) moieties in buparlisib may increase stability and enhance safety profile.
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3D-printed hollow microneedle-based electrochemical sensor for wireless glucose monitoring

Analyst, 2026, 151,1182-1194
DOI: 10.1039/D5AN01058F, Paper

Chuchu Chen, Yonghao Fu, Yuehe Lin, Yun Liu, Dan Du, Kaiyan Qiu
A wearable electrochemical sensor combining a 3D-printed hollow microneedle array, a finger-activated pump, and single-atom nanozymes for highly sensitive glucose monitoring.
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Visualization of heated latent fingerprints by synchrotron radiation soft X-ray photoemission electron microscopy

Analyst, 2026, 151,1163-1171
DOI: 10.1039/D5AN01158B, Paper

Satoru Hamamoto, Masahisa Takatsu, Hiroyuki Fujiwara, Hideya Okada, Takuo Ohkochi, Shimpei Watanabe, Masaki Oura, Yasuo Seto
Synchrotron radiation soft X-ray photoemission electron microscopy can clearly reveal ridge patterns by specifically and sensitively detecting sodium elements in heated fingerprints, which cannot be visualized by usual observation techniques.
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Development of an electrokinetic chromatography method for the rapid enantiomeric determination of 5-hydroxytryptophan. Application to the analysis of dietary supplements

Analyst, 2026, 151,1145-1152
DOI: 10.1039/D5AN01100K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sandra Adámez-Rodríguez, María Luisa Marina, María Castro-Puyana
An EKC method using sulfated-γ-cyclodextrin and short-end injection enabled the rapid enantiomeric separation of 5-HTP for dietary supplement quality control.
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Systematic evaluation of pre-analytical variables on synovial fluid metabolomic profiles using GC-ToF-MS and UHPLC-MS

Analyst, 2026, 151,1130-1144
DOI: 10.1039/D5AN00943J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yumna Ladha, Adam Burke, Nigel Gotts, Royston Goodacre, Karina Wright, Jade Perry, Charlotte H Hulme
This work reveals the critical influence of sample preparation methods on synovial fluid metabolome characterisation.
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Optical photothermal infrared (OPTIR) spectroscopy assisted by machine learning for lactic acid bacteria identification at strain level

Analyst, 2026, 151,1172-1181
DOI: 10.1039/D5AN01093D, Paper

Paul Lagneaux, Nathan Widjaja, Bastien Lagneaux, Thi Kim Chi Nguyen, Hélène Licandro, Pascale Winckler, Yves Waché
Lactic acid bacteria (LAB) are widely used in food, health, and biotechnology sectors. Optical photothermal infrared (OPTIR) spectroscopy assisted by machine learning is explored for improved strain level identification.
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Evaluation of ToF-SIMS imaging for semi-quantitative mapping of BODIPY-labeled fibronectin surface gradients

Analyst, 2026, 151,1118-1129
DOI: 10.1039/D5AN00962F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Chao Liu, Tae Kyong John Kim, Douglas H. Wu, Radhika Atit, Rodrigo A. Somoza, Samuel E. Senyo
A novel semi-quantitative imaging mass spectrometry approach using ToF-SIMS enables high-resolution, sensitive mapping of fibronectin gradients in microfluidic haptotaxis assays beyond the limits of fluorescence microscopy.
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AminoacidDB: a liquid chromatography-tandem mass spectrometry-based toolkit for the untargeted analysis of non-protein amino acids

Analyst, 2026, 151,1071-1085
DOI: 10.1039/D5AN01248A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pawanjit K. Sandhu, Ryland T. Giebelhaus, Ryan Hayward, Tingting Zhao, Alix Tucker, Daniel Gaudet, Tao Huan, Susan J. Murch
Non-protein amino acids (npAAs) are metabolites with amine (NH₂) and carboxyl (COOH) moieties. Their natural diversity is not well understood. We created an analytical toolkit including SOPs, statistical methods and a searchable database of 332,154 metabolites for future studies of npAA.
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Microchip electrophoretic sensing of multiplex microRNAs based on dual nucleic acid amplification

Analyst, 2026, 151,1023-1032
DOI: 10.1039/D5AN00625B, Paper

Qihui Xie, Shuang Tang, Jianan Lv, Xing Geng, Fan Zhang, Qingjiang Wang
A multiplex microRNA detection method based on microchip electrophoresis was developed to achieve high sensitivity and specificity.
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Synchronous dual-mode sensing platform based on 1D chiral ionic COF for epoxiconazole detection

Analyst, 2026, 151,1113-1117
DOI: 10.1039/D5AN01101A, Paper

Yeqian Ruan, Xiaodong Zheng, Xuan Kuang, Shusheng Li
Pesticide misuse leads to environmental contamination and food safety risks.
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Conductive polymer-based electrochemical aptasensor for sensitive detection of cylindrospermopsin in water resources

Analyst, 2026, 151,1100-1112
DOI: 10.1039/D5AN01285F, Paper

Ece Kesici-Meco, Ece Unur-Yilmaz
Conductive polymer-based electrochemical aptasensors enable rapid, sensitive, and selective detection of cylindrospermopsin in water.
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An electrochemical immunosensor based on MXene–Au and Au–Ce-COF to detect methyl parathion

Analyst, 2026, 151,1049-1057
DOI: 10.1039/D5AN01289A, Paper

Peiyao Zhu, Deyu Liu, Yaqi Chen, Haiping Huang, Fang Xu
An electrochemical immunosensor based on MXene nanosheets loaded with AuNPs (MXene–Au) and a cerium-doped covalent organic framework loaded with AuNPs (Au–Ce-COF) was constructed and applied for the ultra-sensitive detection of methyl parathion.
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Development of a PCB-based electrochemical aptasensor for Chikungunya virus protein detection

Analyst, 2026, 151,1153-1162
DOI: 10.1039/D5AN01261A, Paper

Syama Sajikumar, Naveenkumar Sureshkumar, V. V. R. Sai, Verma Jyoti, Sujatha Sunil, Ramanathan Srinivasan
Chikungunya E1 protein detection with 10 pM LOD was achieved with a 10 μL sample on a printed circuit board aptasensor. The hexaammine ruthenium redox couple does not attack the Au layer, enables regeneration, and yields reproducible results.
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