RSC - Analyst latest articles

Dual-parameter self-calibrating probes for organelle polarity by decoupling viscosity from polarity

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00249H, Communication

Lei Huang, Chuanhao Liu, Wenxiao Deng, Yuchang Tan, Yanfei Tan, Yan Huang
To overcome the limitations of intensity- or wavelength-based polarity sensing in cells, we developed a novel fluorophore utilizing steric hindrance to resist viscosity interference while maintaining high polarity sensitivity and PLQY.
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A sensitive electrochemical sensor with Hf-MOF@activated Ketjen black/calix[4]arene composite for the detection of 2,2′-methylenebis(4-chlorophenol) in environmental water

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00351F, Paper

Yu Xie, Jingwen Meng, Zhijie Zhu, Genhe He, Ronghua Hu, Xiuguang Yi, Kalle Salminen
A novel Hf-MOF@activated Ketjen black/calix[4]arenes composite modified electrode sensor was fabricated for the sensitive detection of dichlorophenol in environmental water samples.
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Structure-aware fragment assignment for interpreting tandem mass spectrometry of modified and cyclic peptides

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00162A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

V. Erckes, A. Misiek, A. Streuli, C. Steuer
Cyclized or chemically modified peptidomimetics challenge MS/MS interpretation because fragmentation extends beyond canonical backbone cleavages or needs multiple bond breaks to yield sequence-informative ions.
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Fluorous nanoemulsion optodes with Förster resonance energy transfer-based fluorescence amplification toward highly-sensitive and selective detection of perfluorooctanesulfonate

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00189K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Soraka Iwamoto, Tatsuro Endo, Hideaki Hisamoto
FRET-based fluorous nanoemulsion optodes enable highly sensitive and selective PFOS⁻ detection down to the 10⁻⁸ M level with a rapid response.
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An integrated optofluidic platform enabling label-free single-cell sorting and culture

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00203J, Paper

Baojian Zhang, Fuyuan Chen, Liru Zhao, Mengting Ming, Meina Chen, Chunfang Deng, Yuntong Wang, Huabing Yin, Bei Li, Peng Liang
We present OTMA, an optofluidic platform achieving deterministic, label-free single-cell sorting with >90% viability by decoupling optical trapping from hydrodynamic drag, enabling high-fidelity rare-cell research.
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An IFE-based lysosome-targeted probe for the differential detection and bioimaging of biothiols

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00211K, Paper

Yuan Xu, Yujia Hou, Tongtong Zhao, Huilin Chen, Hanxi Chai, Zhengrui Zhang, Zhuoyan Cao, Kaixin Xie, Qiaoling Liu
Biothiols (Cys, Hcy, and GSH) are generated by reducing disulfide bonds with the help of proteolysis in lysosomes, and these three biothiols play different roles in preserving the optimal activity of lysosomes.
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Ultramicroelectrode fabrication guidelines for multifunctional scanning electrochemical microscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00234J, Paper

Congshan Guo, Zhizhen Lv, Jigui Tang, Jingshu Hui
Dual-disk electrodes with low RG values and narrow gaps were fabricated reproducibly by combining a thick-wall nanopipette template with tip forging.
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Ultrasensitive Triple-Mode Nile Red-L64 Niosome Nanothermometers for Real-Time Cellular Thermogenesis Mapping

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00434B, Paper

Ronak Lazarus, Rupal Kothari, Venkata Vamsi Krishna Venuganti, Amit Nag
Temperature dynamics in living cells provide critical insights into metabolic processes and cellular energy pathways. However, precise intracellular thermometry to measure minimal temperature fluctuations, typically 0.1°C -0.2°C change in the...
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Ultrasensitive, simultaneous detection of two biomarkers with a localized surface plasmon resonance biosensor

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00483K, Paper

Wenyu Xu, Yuanfu Zhang, Yaqi Liu, Lekai Li, Xianfeng Shao, Xueru Chen, Xinzhi Li, Xianxi Zhang, Federico Rosei
A localized surface plasmon resonance (LSPR) biosensor was developed for the simultaneous detection of two components, namely telomerase and fibrin, based on the impact of single-stranded DNA (ssDNA) length on...
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Photo-switchable supramolecular glycochips for capturing suspension tumor cells and real-time profiling of cell surface glycosylation

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00395H, Communication

Biqing Chen, Xian Chen, Lan Chen, Huanyu Liu, Juan Liu, Yuxin Pei, Teodor Aastrup, Yanbin He, Changping Hu, Zhichao Pei, Yuchao Lu
A photo-switchable supramolecular glycochip was fabricated via host–guest complexation between surface-immobilized azobenzene and galactose-modified pillar[5]arene.
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Differentiation of disaccharide isomers via diagnostic-ion-weighted spectral library searching using data from tandem MS analysis of chloride adducts

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00268D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shixiang Xu, Santosh R. Acharya, Ruth M. Speidel, Abraham K. Badu-Tawiah
Chloride adducts of rare sugars enable diagnostic fragment ions to be generated in tandem MS, allowing a highly specific algorithm to be developed to differentiate isomers of rare sugars.
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Synergistic peroxidase-like activity of the Cu–Zn MOF-incorporated g-C3N4 nanozyme integrated with a smartphone-based colorimetric sensor for ciprofloxacin detection

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00320F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Surendhar Sasikumar, Arunjegan Amalraj, Panneerselvam Perumal
Graphical representation of Cu-Zn-MOF/g-C₃N₄ for ciprofloxacin detection.
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In Situ Electrodeposition of Ni(OH)2 Nanoparticles for Highly Sensitive Electrochemical Detection of Ascorbic Acid

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00378H, Paper

Ruijuan Wang, Zhenlan Qin, Xiuju Huang, Congxue Su, Yougang Luo, Yiqi Jing, Rong Wang
Nickel hydroxide (Ni(OH)2) nanoparticles were prepared by in situ electrodepositon onto carbon paper (CP) through comprehensive optimization of deposition parameters, aiming to achieve highly sensitive electrochemical determination of ascorbic acid...
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Raman Spectroscopic Detection of Salivary Thiocyanate for Smoking Exposure Stratification

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00372A, Paper

Pushpak U Shah, Punnya V Angadi, Darshan Chikkanayakanahalli Mukunda, Jiro Karlo, Surya P. Singh
Distinguishing smokers from non-smokers and stratifying the smokers based on their smoking history/exposure (years) is essential for evaluating the risk of tobaccoassociated diseases and supporting early preventive care. It enhances...
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Charge-tunable hemicyanine probes for bacterial imaging and bacterial infection tracking

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00336B, Paper

Kunyi Wang, Yiyang Wang, Wenbo Zhu, Lebin Wang, Zixuan Zhang, Boyaxuan Chen, Wenbo Luo, Xuefei Wang, Zhuo Wang
Charge-tunable hemicyanine probes enable selective imaging of Gram-positive and Gram-negative bacteria, real-time tracking of bacterial infection in host cells, and long-term imaging in complex biological fluids.
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Cyclic cataluminescence method enabled by a heterogeneous electron allocator for multiple-aldehyde detection in tea

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00170J, Paper

Huiting Chen, Mengmeng Ji, Ling Xia, Yufei Hu, Gongke Li
Cyclic chemiluminescence method enabled by a heterogeneous electron allocator for the detection of multiple aldehydes in tea.
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Biochemical composition of prostate core-needle biopsies before and after a single fraction of 13.5 Gy: a Raman spectroscopy-based study

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00128A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kirsty Milligan, Mitchell Wiebe, Alejandra Fuentes, Sandra Popescu, Ramie Ali-Adeeb, Jeffrey Andrews, Julian Lum, Alexandre Brolo, Christina Haston, Bibi Naghibi Torbati, Juanita Crook, Andrew Jirasek
Raman spectroscopy for analysis and characterisation of patient biopsy response to brachytherapy. Carotenoids are found to play a significant role in response dynamics as observed via Raman spectroscopy.
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Lipidomic signatures of CNS ischemic injury and their modulation by immunomodulatory hydrogels

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00089D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mary F. Wang, Yunxin Ouyang, Tatiana Segura, David C. Muddiman
Ischemic injury in the central nervous system (CNS) triggers profound metabolic remodeling that influences inflammation, repair, and cellular survival.
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Identification of volatile organic compound markers for bacterial growth in spacecraft wastewater

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00060F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sarah Kingsley, Hang N. Nguyen, Aaron N. Knopp, Christian L. Castro, Thomas M. Orlando, Sarah L. Castro-Wallace, William T. Wallace
This work presents proof of concept for an MS-based technique for the detection of common spacecraft bacteria in spacecraft wastewater.
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One-step digestion–ligation–activation universal strategy for ultrasensitive detection of DNA methylation

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01270H, Paper

Shiying Zhou, Tao Gu, Liyuan Deng, Xianfeng Wang, Shuyu Zhu, Xinyu He, Mei Yang, Danqun Huo, Changjun Hou
A digestion–ligation–activation strategy integrates methylation-dependent restriction, RLAMP amplification, and CRISPR/Cas12a trans-cleavage into a one-pot cascade for ultrasensitive DNA methylation and methyltransferase analysis.
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A portable acoustic biosensing platform combined with paper-based capillary fluidics for the rapid detection of antibodies in serum

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00114A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dimitra Chronaki, Stylianos Grammatikos, Angelos Ntimtsas, Marios Matsis, Orestis F. Kokolakis, Konstantina Alexaki, Zoi Pournara, Achilleas Tsortos, Alexandros Zafiropoulos, Electra Gizeli
We report the development of a sensitive biosensing platform based on a shear-horizontal surface acoustic wave (SH-SAW) device and paper fluidics, with the potential to be used outside centralized laboratory settings.
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A digital microfluidic integrated SiNW array FET for amplification-free detection of extracellular vesicle-derived miRNAs

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00306K, Paper

Rui Jiang, Jiaqi Guo, Zizhen Wang, Jun Cheng, Han Zhang, Qingzhu Zhang, Lingqian Zhang, Yang Zhao, Chengjun Huang, Mingxiao Li
An integrated DropFET device combining a high-density active-matrix digital microfluidic chip with a silicon nanowire array field-effect transistor sensor enables sample pretreatment and highly sensitive detection of EV–miRNAs.
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Electrochemical determination of nitrofurantoin using a self-templated NiFeCo layered double oxide-carbon composite with dynamic Fe regeneration

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00347H, Paper

Jiang-Tao Chen, Ming-Dong Wang, Fen-Ying Kong, Tian-Pei Cai, Lu-Mei Wang, Juan-Juan Gao, Wei Wang
A NiFeCo layered double oxide supported N,S co-doped collagen-derived porous carbon (NiFeCo LDO-C) enables trace-level electrochemical detection of nitrofurantoin via dynamic metal active-site regeneration and self-template/self-etching strategy.
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Surface-enhanced Raman spectroscopy for comprehensive urinalysis: advances, challenges, and clinical perspectives

Analyst, 2026, 151,2747-2762
DOI: 10.1039/D6AN00201C, Tutorial Review

Si Chen, Yuemei Chen, Yuxin Liu, Chunying Zhang, Jianke Yang, Xiaoqin Xu, Tonghao Zhang, Yali Song, Tingting Zeng
Urine, a noninvasive, information-rich biofluid, reflects systemic and urological physiology via metabolites, biomarkers, and drug residues. SERS enables rapid, sensitive, label-free molecular profiling, supporting potential clinical applications.
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Advances of hydrogel-modified silica as the stationary phase in high-performance liquid chromatography

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00404K, Perspective

Tong Zhang, Xiaojing Liang, Hongfang Lin, Rui Liu, Na Li, Zhixia Li, Lei Liu, Yuting Zhang
Hydrogel-functionalized silica is used as the stationary phase in liquid chromatography.
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A two-point fluorescence detection flow cell with empirical calibration for high optical density analysis

Analyst, 2026, 151,2767-2772
DOI: 10.1039/D6AN00106H, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Tin Weitner, Davor Šakić
A dual-detector fluorescence flow cell with software calibration enables accurate quantification at previously inaccessible high optical densities.
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Analysis of cholesterol-induced mechanical modulation of cell membranes by nanopipette-generated fluid flow

Analyst, 2026, 151,2763-2766
DOI: 10.1039/D6AN00067C, Communication

Shu-Yue Xu, Meng-Qi Zhao, Xin-Yue Liu, Ming-Jie Ye, Bin-Bin Chen, Da-Wei Li, Mahmoud Elsayed Hafez, Jian Lv, Ruo-Can Qian
A label-free membrane oscillation strategy based on nanopipette-generated fluid flow to investigate cholesterol-induced mechanical alterations in living cell membranes.
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A metaproteomic platform for integrated host-pathogen-microbiota profiling in zebrafish larvae

Analyst, 2026, 151,2773-2780
DOI: 10.1039/D6AN00088F, Communication

Javiera Ortiz-Severín, Antonia Ramos-Guzmán, Ian Pérez, Miguel L. Allende, Francisco P. Chávez
Understanding host–pathogen–microbiota interactions requires analytical strategies capable of resolving multiple biological compartments within a single experimental framework.
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Time-domain luminescence lifetime imaging with oxygen sensor particles in the presence of actinic light

Analyst, 2026, 151,2800-2809
DOI: 10.1039/D6AN00122J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Georg Schwendt, Michael Kühl
Fast and robust oxygen imaging under photon irradiance levels corresponding to mid-day solar irradiation.
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Design of a “turn-on” colorimetric sensor for AChE inhibitors based on the instability of metal–organic frameworks

Analyst, 2026, 151,2995-3003
DOI: 10.1039/D6AN00156D, Paper

Jun Zhang, Wenzhu Jiang, Zhiping Xu, Lin Zhang
Illustration of the colorimetric assay based on Cu-BTC with peroxidase-like activity for the AChE inhibitor.
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Disentangling method-induced differences in metabolomics: single- versus dual-phase extraction

Analyst, 2026, 151,2842-2851
DOI: 10.1039/D6AN00025H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sehyeon (Erica) Kim, Tao Huan
A systematic LC-MS metabolomics comparison reveals how pipetting, partitioning, and matrix effects drive differences between single- and dual-phase extractions, providing a framework for optimizing metabolite recovery and analytical performance.
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The infinite-dimensional nature of spectroscopy and why models succeed, fail, and mislead

Analyst, 2026, 151,2978-2994
DOI: 10.1039/D6AN00346J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Umberto Michelucci, Francesca Venturini
Machine learning (ML) models have achieved high accuracies in spectroscopic classification, without a clear proof that those models used chemical features. High dimensionality offers a shortcut for models to achieve the performance we observe.
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Flavourings, nicotine content, and elemental composition as indicators of regulatory compliance in nicotine pouches and heated tobacco products

Analyst, 2026, 151,2962-2977
DOI: 10.1039/D6AN00153J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Matjaž Rantaša, Matjaž Finšgar
Nicotine pouches (NPs) and heated tobacco products using heatsticks (HSs) are relatively new alternatives to traditional smoking.
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Se-, S-, and N-doped carbon dot-based AuNPs for the detection of 6-methylnicotine in e-cigarettes by surface-enhanced Raman scattering

Analyst, 2026, 151,2907-2916
DOI: 10.1039/D5AN01296A, Paper

Zhao Zhao, Qianqian Pang, Xi Wang, Zhichao Chen, Xianfang Rong, Yaling Yang
Using S-, Se-, N-doped carbon dots, SERS-active gold nanoparticles were prepared. A sensitive sensor for 6-methyl nicotine in e-cigarettes was established via specific S-Au/Se-Au/N-Au interactions, with a detection limit of 0.13 μg L⁻¹.
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Shell-switchable SERS blocking strategy for quantitative copper ion detection using single-particle SERS probes

Analyst, 2026, 151,2810-2817
DOI: 10.1039/D6AN00174B, Paper

Longteng Liang, Yingqing Zhu, Anran Wang, Lixia Li, Ning Feng, Yufang Liu
A shell-switchable SERS blocking strategy using single-particle probes enables accurate Cu²⁺ quantification via oxidative etching-mediated Raman intensity regulation.
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Predictive analysis of organic semiconductor photodegradation by FTIR spectroscopy with multivariate analysis

Analyst, 2026, 151,2858-2867
DOI: 10.1039/D5AN01007A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sarah M. Tyler, Thomas J. Blackburn, Kellen T. Schneider, Jeanne E. Pemberton
Evaluation of ATR-FTIR as a predictive tool for characterizing organic semiconductor degradation is discussed. Accurate classification of degradation is demonstrated with multivariate analysis tools.
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Bacterial imprinted polymer-based detection of Escherichia coli using polydopamine on gold nanodendrite/graphene oxide modified electrodes

Analyst, 2026, 151,2831-2841
DOI: 10.1039/D5AN01217A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yilei Xue, Jessica Chen, Meissam Noroozifar, Ruby May A. Sullan, Kagan Kerman
An electrochemical biosensor based on a glassy carbon electrode modified with graphene oxide, gold nanodendrites, and polydopamine was developed with Escherichia coli imprinted on the surface.
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Environmentally benign synthesis of blue fluorescent graphene quantum dots for nitroaromatic sensing (p-nitroaniline and 2,4,6-trinitrophenol) and their nanophytotoxicity analysis

Analyst, 2026, 151,2888-2906
DOI: 10.1039/D6AN00045B, Paper

Krishna Moni Deka, Saikat Das, Rachita Newar, Rajkanya Das, Bappy Sen, Hemen Sarma, Arabinda Baruah
Blue fluorescent graphene quantum dots for nitroaromatic sensing (p-nitroaniline and 2,4,6-trinitrophenol) and analysis of their nanophytotoxicity.
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In situ growth of Pd nanoparticles on wood for highly sensitive hydrogen sensing

Analyst, 2026, 151,2917-2926
DOI: 10.1039/D6AN00185H, Paper

Wanli Lin, Ming Li, Zechun Li, Shaojin Shi, Changkun Zhu, Jun Yan, Ying Chen, Pengcheng Xu, Xinxin Li
In situ growth of Pd nanoparticles on wood as a catalyst for developing a highly sensitive MEMS thermopile H₂ sensor.
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Metal–organic framework-based molecularly imprinted polymers for the dispersive solid-phase extraction of fluoroquinolones in coastal zone water and biological samples

Analyst, 2026, 151,2818-2830
DOI: 10.1039/D6AN00241B, Paper

Jingying Huang, Jingyi Yan, Mingsan Man, Saqib Farooq, Zihan Qiu, Shuai Wu, Liangwei Zhang, Lingxin Chen, Jinhua Li
MOF-MIPs-based DSPE coupled with HPLC–UV was developed as a strategy for the simultaneous determination of six FQs in coastal zone water and biological samples.
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Thiol–phenolic interactions in electropolymerized methimazole enable superior isomer discrimination for hydroquinone and catechol sensing

Analyst, 2026, 151,2951-2961
DOI: 10.1039/D6AN00061D, Paper

Dexian Kong, Jiajin Feng, Shiting Deng, Mingwei Yang, Yuwu Chi
A new electropolymerized methimazole (p-MMI) film-modified glassy carbon electrode was developed for simultaneous detection of hydroquinone (HQ) and catechol (CC).
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A nickel-based bipolar electrochemiluminescence platform for glucose detection

Analyst, 2026, 151,2852-2857
DOI: 10.1039/D6AN00092D, Paper

Xianchuan Dong, Yaoxuan Wang, Jing Sui, Siqi Huang, Feifei Zhang, Zonghua Wang
This study describes a 10-channel bipolar ECL sensing device employing nickel as the electrode material for the sensitive detection of glucose in human urine. The device can be powered by two commercially available AA batteries.
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Portable and point-of-care molecular detection of pathogenic Vibrio parahaemolyticus in shrimp

Analyst, 2026, 151,2791-2799
DOI: 10.1039/D6AN00099A, Paper

Thi Ngoc Diep Trinh, Kieu The Loan Trinh, Hanh An Nguyen, Huynh Minh Triet Nguyen, Nguyen Thi Hong Nhi, Vo Thi Tuyet Minh, Nguyen Nhat Nam, Nae Yoon Lee
A portable and fully-integrated point-of-care molecular diagnostic device detecting pathogenic Vibrio parahaemolyticus carrying pirA gene which causes Acute Hepatopancreatic Necrosis Disease in shrimp is developed.
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An ultra-sensitive photoelectrochemical aptasensor based on a CdIn2S4/ZnSnO3 composite for the detection of adenosine triphosphate

Analyst, 2026, 151,2879-2887
DOI: 10.1039/D6AN00158K, Paper

Ling Zhang, Lu-Ying Wang, Yu-Ping Wei, Jing-Shuai Chen, Hui Zhu, Xing-Pei Liu, Chang-Jie Mao, Bao-Kang Jin
We present a highly sensitive PEC aptasensor for ATP detection based on CIS/ZSO heterojunction and nanozyme-catalyzed precipitation amplification.The sensor exhibits excellent stability, selectivity and potential for serum ATP analysis.
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Quantitative analysis of colorimetric hydrogel/paper mini-disk arrays using a handheld Wi-Fi scanner

Analyst, 2026, 151,2868-2878
DOI: 10.1039/D6AN00255B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lin Qi, Pitipat Parittothok, Sophia Sun, Jakrapop Wongwiwat, Aluck Thipayarat, Wanida Laiwattanapaisal, Hua-Zhong Yu
A point-of-need analytical protocol for quantitative colormetric assays by integrating hydrogel-paper mini-disks, a handheld scanner, and a custom-designed app.
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Improving the resolution of permanent gas analytes using solvent gas in gas chromatography

Analyst, 2026, 151,2945-2950
DOI: 10.1039/D6AN00147E, Paper

Matthew Messner, Yugang Sun
Solvent gas can be used as an accessible approach to improve the separation of permanent gases on porous layer open tubular (PLOT) columns in gas chromatography (GC).
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A practical framework for super-resolution of mass spectrometry images via adaptation of deep learning models

Analyst, 2026, 151,2935-2944
DOI: 10.1039/D6AN00012F, Paper

Yinghao Cao, Yuting Tan, Chang Li, Erping Long, Lin Wang
Four architectures (SwinIR, MambaIR, ResShift, MOSR) were compared for MSI super-resolution. MOSR and bicubic-pretrained ResShift performed best. Fine-tuning ResShift with ten mouse brain sections outperformed both.
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Separating O-desmethylvenlafaxine and tramadol enantiomers using two-dimensional chiral LC × DMS mass spectrometry

Analyst, 2026, 151,2781-2790
DOI: 10.1039/D6AN00119J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

A. Dawson McLachlan, Rashne Vakharia, Emir Nazdrajić, Diana M. Cárdenas-Soracá, Leslie M. Bragg, Mark R. Servos, W. Scott Hopkins
A novel hybrid workflow including chiral LC and differential mobility spectrometry was used to separate and quantify the enantiomers of a set of co-eluting isomers.
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Electrochemical evaluation of plant extracts as potential antidotes for acetaminophen poisoning

Analyst, 2026, 151,2927-2934
DOI: 10.1039/D5AN01322D, Paper

Rahim Babereh, Hassan Shayani-Jam, Mohammad Reza Yaftian, Bahman Farajmand, Mohammad Hassan Moeini, Shadi Moeinifar
Acetaminophen, a widely used analgesic, causes severe liver damage in overdose situations due to N-acetyl-p-benzoquinoneimine (NAPQI), a toxic metabolic intermediate.
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Fix or freeze? Spectral differences arising from tissue preparation in chemical imaging

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00137H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tianyi Zheng, Wihan Adi, Paul J. Campagnola, Filiz Yesilkoy
Quantum cascade laser (QCL)-based mid-infrared spectrochemical imaging reveals that tissue preparation methods substantially alter the biochemical and morphological information captures from biological tissues, with fresh frozen samples preserving greater native spectral diversity than FFPE tissues.
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Polarization–preservation analysis for robust reflection-mode optical glucose sensing in turbid media

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00257A, Paper

Hsin-Yi Hsieh, Chia-Chun Chang, Chin-Chuan Hsieh
Circular polarization combined with a PPR metric improves correlation and robustness over linear polarization with DOP in reflection-mode glucose sensing through turbid media.
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A novel electrochemiluminescence sensor using Lu-Au@Ni-MOF for ultra-sensitive detection of permethrin

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00409A, Paper

Yahui Ji, Nana You, Xiaoping Hu, Fangxin Du, Hui Gao, Jie Ru, Gen Liu
A novel quenching ECL sensor is developed using a Lu-Au@Ni-MOF nanocomposite, which enables the ultrasensitive and selective detection of PT through an efficient signal amplification strategy of Lu-Au@Ni-MOF.
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High-performance formic acid gas detection using a quartz crystal microbalance functionalized with Cdot-decorated polyvinyl acetate nanofibers

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00209A, Paper

Chlara Naren Maharani, Henny Afiyanti, Firdausya Danuansa, Ihsan Nurijal, Roto Roto, Aditya Rianjanu, Kuwat Triyana, Witha Berlian Kesuma Putri, Rizky Aflaha
This study successfully obtained a high-performance formic acid sensor using Cdot-decorated PVAc nanofibers. The fabricated sensor shows a 20× sensitivity increase and high selectivity.
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Photothermal microscopy beyond intensity detection: exploiting spatial signal distributions for enhanced sensitivity

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00046K, Paper

Shu-hei Urashima, Tomotaro Namba, Ryoji Kusaka
Exploiting pump–probe spatial mismatch enables up to a sixfold improvement in the limit of detection for photothermal microscopy beyond conventional spectrophotometers while preserving microscopic spatial resolution.
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Sulfonic acid-functionalized ordered mesoporous silica as a dispersive solid-phase extraction adsorbent for the determination of 30 organophosphorus pesticides

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00377J, Paper

Zhimou Chen, Changlong Hao, Hua Kuang, Chuanlai Xu
Sulfonic acid-functionalized ordered mesoporous silica was developed as an efficient DSPE adsorbent for simultaneous determination of 30 organophosphorus pesticides, achieving rapid adsorption and elution with low LODs and good recoveries.
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Data-driven optimization for controllable multi-scale aperture fabrication of nanopipettes

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00232C, Paper

Runan Guo, Zhi Chen, Xue Han, Rongke Sun, Hui Lu, Yanqing Ma, Lei Ma
This work realizes controllable multiscale aperture fabrication of nanopipettes (50–1000 nm) integrates an artificial neural network, feature importance analysis, and a mechanical physical model.
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Revealing Potassium Ion Storage at Individual Prussian Blue Nanoparticles with Distinct Crystallinity via Scanning Electrochemical Cell Microscopy

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00435K, Paper

Mengyao Cao, Yaqi Xiong, Cong Gao, Xinyu Guo, Jia Yin, Mahmoud Elsayed Hafez, Qianjin Chen
Potassium-ion batteries (KIBs) have gained tremendous attention due to the abundance and low cost of potassium resources. However, challenges such as significant voltage hysteresis and sluggish diffusion kinetics request a...
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Defect-coupled cooperative catalysis enables a highly active MOF-on-MOF nanozyme for direct discrimination of dihydroxybenzene isomers

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00287K, Paper

Zhongfang Hu, Yuanyuan Sun, Xiaorong Sun, Yuming Dong, Guang-Li Wang
A defect-engineered MOF-on-MOF nanozyme with high oxidase-like activity was developed for direct discriminative recognition of resorcinol among dihydroxybenzene isomers.
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Feasibility study of superoxide chemical ionization mass spectrometry (O2− CIMS) for real-time gas-phase measurements of per- and polyfluoroalkyl substances (PFAS)

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01352F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yufan Hu, Joji W. Sherman, Michael J. Davern, Zane A. Alsebai, Yoonsub Kim, Yue Zhang, Chenyang Bi, Barbara J. Turpin, Jason D. Surratt
O₂⁻ as a CIMS reagent ion enables safer usage and fingerprint ion peaks for PFAS compound confirmation while providing higher sensitivity and lower limits of detection for real-time gas-phase measurements of several PFAS compared to current methods.
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Multiplexed profiling of breast cancer exosomes based on an asymmetric bipolar electrode electrochemiluminescence immunochip

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00356G, Paper

Xin Hua, Jianmei Han, Tingting Han, Gaohua Han, Wei Zhang, Ran Chen, Songqin Liu
A four-channel asymmetric bipolar electrode-based microfluidic chip was developed for highly sensitive and multiplexed profiling of breast cancer exosomes.
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Molybdenum disulfide quantum dots as dual-functional catalysts and coreactants for enhanced Ru(bpy)32+ electrochemiluminescence

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00290K, Paper

Xiu Yang, Jianjun Shi, Hui Zhu, Changjie Mao
Schematic of Ru(bpy)₃²⁺-ECL enhancement by MoS₂ QDs and ECL quenching by DA.
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Evaluation of vardenafil's metabolic stability in human liver microsomes through ultra-fast UPLC-MS/MS for quantitative analysis, including assessments of greenness, ADME properties, DEREK alerts, and metabolic lability

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00200E, Paper

Mohamed W. Attwa, Adnan A. Kadi
The current UPLC-MS/MS method is considered the first analytical method for vardenafil quantification in the HLMs matrix. Small changes to the 4-ethylpiperazine ring in drug design could improve the metabolic stability of new vardenafil derivatives.
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Quantitative analysis of sequential nucleic acid elution from silica paramagnetic beads

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00127K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Asher Varon, Justin Schares, Kuangwen Hsieh, Bradley Downs, Tza-Huei Wang
Paramagnetic beads enable diverse biochemical assays. A systemic investigation into sequential nucleic acid elution, was quantitatively characterized across multiple elution steps.
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Microscope observation of united liposome trajectories near a polarized ultramicroelectrode surface

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00252H, Paper

Arthur Langlard, Christine Thobie-Gautier, Mohammed Boujtita, Estelle Lebègue
An ultramicroscopy setup built for tracking the positions of liposomes, in the plane of their trajectories between the bulk solution and the ultramicroelectrode disk surface that is polarized during blocking impact experiments.
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Quantitative metabolomics identifies prognostic biomarkers associated with NSCLC after chemoradiotherapy

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00069J, Paper

Leirui Yuan, Linfang Wu, Mingmin Qian, Chenxi Li, Daquan Wang, Xiang Fang, Shanlin Mao, Di Yang, Minghao Wang, Luhua Wang, Zeper Abliz, Nan Bi, Yanhua Chen
Targeted quantitative metabolomics of pretreatment plasma identified GSH and LPC18:3 as prognostic biomarkers in stage III NSCLC. High GSH predicted better survival, whereas high LPC18:3 indicated a poorer outcome after chemoradiotherapy.
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Selective detection of lipophagy with a highly specific lipid droplet probe

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01241D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shixiong Wen, Xiaoxue Zou, Jianing Liu, Jiahuai Han, Shoufa Han
Lipophagy, the autophagic degradation of lipid droplets (LDs) by lysosomes, is an important route for maintaining LD homeostasis.
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A pH-responsive ratiometric fluorescent probe and its application in bioimaging and food freshness monitoring

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00471G, Paper

Huan Wang, Tao Zhang
A water-soluble ratiometric fluorescent probe with dual-emission upon single excitation has been successfully developed for tracking pH changes within mitochondria and for detecting food freshness.
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DVB-cross-link latex microspheres to uniformly host Eu(Ⅲ) chelates with moderate swelling capacity for high performance quantitative LFIA strips

Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D6AN00194G, Paper

Jiannan Jia, Hongjian Chen, Songle Wang, Yunpeng Wang, Qike Wang, Dong Chen, Shisheng Ling, Wenkun Dong, Zhenzhen Ge, Mi Yan, Zhiyu Wang, Xianping Fan, Xu Liang, Qiang Xu, Xusheng Qiao
Eu complex swollen polystyrene (PS) fluorescent microspheres have already attracted considerable attention in the field of lateral flow immunoassay (LFIA) biodetection. However, the over excessive swelling and the induced concentration...
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Simultaneous quantitation of structurally analogous bile acid isomers via charge-state-engineered UPLC-MS

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00420B, Paper

Desen Su, Yunyun Zheng, Xiuxian Lin, Ziqiang Chen, Minmin Huang, Qinghua Yao, Yuwu Chi
An advanced UPLC-MS approach utilizing alkaline charge-state homogenization efficiently separates four bile acid isomers (ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, and deoxycholic acid), providing high sensitivity and robust quantification in complex biological matrices.
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A new benzothiazoloacetonitrile-derived fluorescent probe for selective hydrazine detection and its applications in bioimaging and cotton swab analysis

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00062B, Paper

Nikita Kush Durgi, Ramesh D. K., Kiran B. Manjappa, Prasad Pralhad Pujar
A new benzothiazoloacetonitrile-based fluorescent probe was synthesised for hydrazine detection with an LOD value of 0.21 µM and was employed in bioimaging and cotton swab applications.
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Upcycling lemon peel waste into sustainable bioactive ingredients: chemical characterization and efficacy assessment

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00048G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ritamaria Di Lorenzo, Ilaria Neri, Raffaele Raimondo, Daniela Di Matteo, Carlo Irace, Maria Grazia Ferraro, Mariavittoria Verrillo, Teresa Ponticorvo, Teresa Di Serio, Sonia Laneri, Lucia Grumetto
Supercritical fluid extraction of bioactive compounds from dried lemon peel, an agro-industrial waste, to support sustainable valorization strategies.
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Advances and opportunities in point-of-care detection of toxic metals: a review of electrochemical and non-electrochemical approaches

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00248J, Critical Review

Navoda Udawaththa, Olga Zubak, Ashley Daninger, Ralph Page, Miriam Strini, Brianna Romero, Pavithra Pathirathna
Heavy metal contamination remains a persistent global threat to human health and the environment, driving the urgent need for rapid, portable, and sensitive detection technologies.
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Multi-modal structure characterization of synthetic batch impurities with liquid chromatography coupled to infrared ion spectroscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01339A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Teun van Wieringen, Simon J. Perry, Agisilaos Chantzis, Giel Berden, Jos Oomens, Mansoor Saeed, Jonathan Martens
By combining IR ion spectroscopy, chromatography and quantum-chemical spectral predictions, five synthetic impurities are identified. Born-Oppenheimer molecular dynamics calculations are used to improve the spectral predictions.
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Fluorescent nanodiamonds: preparation and quantum sensing for biological analysis

Analyst, 2026, 151,2447-2467
DOI: 10.1039/D6AN00103C, Minireview

Shingo Sotoma, Kota Shiraya, Daisuke Fujimaki, Kai Otsu
Fluorescent nanodiamonds containing nitrogen-vacancy centers are next-generation bioprobes. This Minireview outlines their preparation and surveys their applications to intracellular temperature, radical, and rotational sensing.
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Reusable interface-decoupled organic photoelectrochemical transistor biosensing for acetylcholinesterase activity and its inhibitor detection

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00315J, Paper

Huijin Lin, Huihui Cai, Hua-Yue Xiong, Jinting Sun, De-Man Han, Feng-Zao Chen, Chaobiao Huang
An innovative interface-decoupled organic photoelectrochemical transistor (ID-OPECT) sensor was developed, featuring an external photon-gating module for highly responsive and reusable acetylcholinesterase and chlorpyrifos detection.
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A nanopore-based enzyme-assisted biomarker detection method for chronic obstructive pulmonary disease

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00373G, Paper

Qianyuan Ren, Yakun Yi, Shihong Li
We present a nanopore-based dual-biomarker assay for ultrasensitive miR-150-5p and VEGF165 detection, providing a promising method for early screening of Chronic obstructive pulmonary disease (COPD) and its associated pulmonary hypertension.
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Visualizing nanoplastic–metal ion co-exposure stress with an NIR biothiol responsive fluorescent probe

Analyst, 2026, Advance Article
DOI: 10.1039/D6AN00278A, Paper

Shaoyu Wei, Liangwei Zhang, Jiangkun Tan, Shudi Liu, Maryam Arabi, Abbas Ostovan, Xuming Zhuang, Lingxin Chen
A near infrared biothiol fluorescent probe has been developed for studying nanoplastic–metal ion complex co-exposure induced oxidative stress, revealing that charge and lysosomal function may be involved in the process.
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Organoid models through the lens of metabolomics: a systematic review of experimental applications and analytical approaches

Analyst, 2026, 151,2489-2503
DOI: 10.1039/D6AN00186F, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Martina Lombardi, Andrea Ingenito, Antonietta Santoro, Jacopo Troisi
Organoid models have transformed experimental biology by enabling three-dimensional systems that recapitulate tissue architecture, cellular heterogeneity, and metabolic activity patterns more faithfully than conventional in vitro cultures.
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Electrochemiluminescence of a novel iridium(III) complex with dual-potential emission and its application in chloramphenicol sensing

Analyst, 2026, 151,2528-2532
DOI: 10.1039/D6AN00173D, Communication

Tongtong Li, Yingying Su, Mingxia Sun, Hongjie Song, Yi Lv
Three Ir(C^N)₂(N^N)⁺ complexes with the same C^N ligand and different N^N ligands were synthesized, and their ECL properties were systematically investigated using TPA or K₂S₂O₈ as coreactants.
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From materials to systems: recent advances on electrochemical sensors for capsaicin detection

Analyst, 2026, 151,2423-2446
DOI: 10.1039/D5AN01193K, Minireview

Huirou Zhou, Shasha He, Rahim Rahimi, Hongjie Jiang
Recent advances in electrochemical capsaicin detection, highlighting progress in electrode sensing materials and their translation into sensing technologies.
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Advances in single-molecule junctions for the detection of hazardous pollutants

Analyst, 2026, 151,2504-2522
DOI: 10.1039/D5AN01256B, Tutorial Review

Long-Long Zhou, Jun-Hua Chen, Li-Na Luo, Jia-Ying Huang, Ya-Hao Wang, Shaoshao Jiao, Xiao-Shun Zhou
This graphical abstract shows single-molecule junctions (SMJs) as ultrasensitive platforms for pollutant detection, covering inorganic, organic, and microbial pollutants, as well as current challenges and future directions.
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State-of-the-art of surface-enhanced Raman spectroscopy for pathogenic bacterial identification

Analyst, 2026, 151,2468-2488
DOI: 10.1039/D6AN00039H, Critical Review

Juntian Jiang, Chao Yan, Sibo Wang, Bing Zhao, Xuesong Xu, Weidong Ruan, Xiang Wang
SERS enables rapid, sensitive bacterial identification. This review highlights advances in substrates, sample enrichment and AI/ML spectral analysis, and outlines key challenges for standardised clinical translation.
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Lyophilised colourimetric LAMP for visual readout with dual colour indicators

Analyst, 2026, 151,2650-2661
DOI: 10.1039/D5AN01238D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kenny Malpartida-Cardenas, Oliver W. Stringer, Matthew L. Cavuto, Alison Holmes, Jesus Rodriguez-Manzano
Development and optimisation of ready-to-use lyophilised colourimetric LAMP (lyo-cLAMP) integrating pH and metal indicators, only requiring addition of extracted nucleic acids. Compatible with any LAMP assay, it enables adaptation to any target.
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Glycan signal enhancement by ammonium fluoride doping and electrospray diverting

Analyst, 2026, 151,2704-2710
DOI: 10.1039/D6AN00090H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Seth M. Eisenberg, David C. Muddiman
By combining ammonium fluoride electrospray doping with an electrospray diverter, signals of N-linked glycans were significantly enhanced.
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Stable focusing of proteins within a packed microbead bed by ion concentration polarization in a paper-based analytical device

Analyst, 2026, 151,2638-2649
DOI: 10.1039/D6AN00004E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sommer Osman, Kira L. Rahn, Quinlan G. Pollak, Md Ruhul Amin, Robbyn K. Anand
Embedded beads stabilize electrokinetic preconcentration in a paper LFA, while antibody functionalization enables antigen retention after the electric field is removed.
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A hollow-core fiber based optofluidic chip for rapid immunofluorescence detection with simultaneous enhancement of sensitivity and enrichment efficiency

Analyst, 2026, 151,2602-2612
DOI: 10.1039/D5AN01308A, Paper

Xiao Ren, Tian Wen, Yukai Liu, Xiaoxian Liu, Feng Lin, Zhenyong Dong, Hao Wang, Lunbiao Cui, Yan-qing Lu, Guanghui Wang
An optical microfluidic chip integrating a functionalized hollow-core fiber achieves rapid and highly sensitive detection of influenza A virus through waveguide-confined fluorescence excitation enhancement and efficient collection.
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High- and low-field NMR in binary solvent gradients

Analyst, 2026, 151,2662-2668
DOI: 10.1039/D6AN00031B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Haider Hussain, Paulina Putko, Dariusz Gołowicz, Krzysztof Kazimierczuk, Matthew Wallace
Gradients in the solvent composition of NMR samples are generated by layering two solvents of contrasting densities. Spectra are recorded at different compositions by physical movement of the tube (low-field) or chemical shift imaging (high-field).
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A spatially invariant noise model for minimum noise fraction (MNF) denoising of hyperspectral datasets: applications to large-scale infrared spectroscopic pathology

Analyst, 2026, 151,2624-2637
DOI: 10.1039/D6AN00152A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dougal Ferguson, Peter Gardner
A spatially invariant version of the Minimum Noise Fraction denoising algorithm (iMNF) that removes the spatial-order dependency of standard MNF, keeping biochemical fidelity across unstructured datasets or datasets analysed in a patch-wise manner*.
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A machine learning-assisted Cu-MOF/OPD/RB triple-emission ratiometric fluorescence sensing platform for the detection and discrimination of glutathione

Analyst, 2026, 151,2584-2592
DOI: 10.1039/D6AN00116E, Paper

Shiwen Wu, Shuqi Wang, Hui Xie, Yaxin Li, Hongzhi Lu, Shuzhen Zheng, Shuai Sun, Shoufang Xu
Preparation of a Cu-MOF and the construction of a triple-emission ratiometric fluorescent probe (A); the ratiometric fluorescence detection of GSH (B); and the machine learning-assisted intelligent discrimination of analogous substances (C).
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Simultaneous qualitative and quantitative analysis of tyloxapol in tobramycin eye drops by LC-Q-TOF and HPLC-ELSD

Analyst, 2026, 151,2694-2703
DOI: 10.1039/D6AN00042H, Paper

Shengjun Che, Chen Liang, Min Yan, Xiaoru Zhang, Wenfeng Zheng
An innovative combined qualitative and quantitative method for detecting the content of tyloxapol in tobramycin eye drops.
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Machine learning-driven multidimensional tea profiling from a single SERS spectrum: toward practical application

Analyst, 2026, 151,2711-2720
DOI: 10.1039/D6AN00093B, Paper

Jincheng Ni, Yanyan Lu, Xuewen Chen, Haoming Bao, Yu Qiao, Shuai Zhang, Daoshuan Ding, Jiamei Jin, Huaiyuan Zhao, Qian Zhao, Jinhua Wang, Hongwen Zhang, Weiping Cai
A single SERS spectrum, analysed using machine learning, enables multidimensional tea authentication, resolving category, grade, storage quality, and pesticide residues with up to ≥98.9% accuracy, moving toward practical application.
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Micro-SORS and machine learning for the non-invasive reference-free study of subsurface pigment degradation

Analyst, 2026, 151,2563-2573
DOI: 10.1039/D5AN01176K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

A. Lux, J. Schlanz, A. Botteon, L. Monico, P. Matousek, R. I. Dima, C. Conti, P. Strobbia
The study presents the development of micro-spatially offset Raman spectroscopy (micro-SORS) methods and data analysis routines for the study of pigment degradation processes in the cultural heritage field.
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Classification of recycled plastics using sparse and imbalanced spectral data and data augmentation by the generative adversarial network

Analyst, 2026, 151,2552-2562
DOI: 10.1039/D5AN01042J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xuan Liu, Xuerui Song, Yusuf Sulub, David Zoller, Zhenyu (James) Kong, Blake N. Johnson
Data augmentation with a Generative Adversarial Network improves FTIR spectra classification for accurate plastic sorting and recycling applications.
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Utilizing Venturi effect for automated high-throughput droplet-MS from well plates

Analyst, 2026, 151,2533-2543
DOI: 10.1039/D6AN00065G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Bridget E. Murray, Roger C. Diehl, Moritz Pott, Daniel A. Holland-Moritz, Alison R. H. Narayan, Robert T. Kennedy
We demonstrate a high-throughput (0.4 samples per s) and automated droplet-MS method for analysis of enzyme reactions.
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An adaptive weighted polynomial baseline correction method for electrochemical aptamer-based sensors

Analyst, 2026, 151,2669-2681
DOI: 10.1039/D5AN01347J, Paper

Zhijian Wen, Yasmin Liu, Emeka J. Itumoh, Janet Stacey, James M. Curran, Onyekachi Raymond
An adaptive polynomial baseline correction method developed for square-wave voltammetry (SWV) data to identify non-informative regions, apply weighted polynomial fitting, and select the optimal order for accurate baseline estimation.
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Electrokinetic separation of bacteriophage ϕKZ from bacterial cells

Analyst, 2026, 151,2682-2693
DOI: 10.1039/D5AN01220A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Viswateja Kasarabada, Zakia Azad, Julie A. Thomas, Blanca H. Lapizco-Encinas
Binding-induced zeta potential shifts facilitated the electrokinetic streaming separations of bacteriophage ϕKZ from Escherichia coli at 194.3 V/cm and 430.4 V/cm. A streaming–trapping approach selectively immobilized bacterial cells at 580.6 V/cm.
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Focused traveling surface acoustic wave-based acoustofluidic chip for label-free cell sorting

Analyst, 2026, 151,2613-2623
DOI: 10.1039/D5AN01350J, Paper

Jingxiang Deng, Yang Yang, Zixin Wang, Haiping Zhao, Hao Chen, Lingqian Zhang, Mingxiao Li, Yang Zhao, Chengjun Huang
A label-free FTSAW acoustofluidic chip enabling red and white blood cell sorting.
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Chaperone polymer-enhanced microRNA sensing on a surface-functionalised power-free microchip

Analyst, 2026, 151,2523-2527
DOI: 10.1039/D6AN00188B, Communication

Ryo Ishihara, Kotomi Katori, Manaya Ogawa, Mutsumi Hosono, Yingfan Mu, Ren Ogata, Hinako Yokohari, Rin Hirose, Eri Shimura, Takeshi Baba, Naoko Yoshida, Naoki Yoshida, Atsushi Maruyama
Artificial chaperone polymer-enhanced hybridisation enabled the sensitive and specific detection of hsa-miR-500a-3p, a liquid biopsy biomarker, from a 1.0 µL sample within 15 minutes using a portable surface-functionalised power-free microchip.
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Construction of a smartphone-assisted colorimetric nanosensor with multi-antibiotic response based on silver–ceria nanocomposites mimicking peroxidase activity

Analyst, 2026, 151,2574-2583
DOI: 10.1039/D6AN00082G, Paper

Yinxia Yang, Yi Liu, Jialin Liang, Qian Zhao, Shi Gang Liu, Jie Luo
A smartphone-assisted colorimetric nanosensor with multi-antibiotic response based on silver–ceria nanocomposites mimicking peroxidase activity is designed and applied for rapid detection of antibiotics in real samples.
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Super-lightweight, low-cost and wireless water quality monitor for remote chlorine rate management in water-circulating cooling facilities

Analyst, 2026, 151,2593-2601
DOI: 10.1039/D6AN00029K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Masayuki Kawakami, Toshihiro Kasama, Tomomi Sato, Hidekatsu Tazawa, Madoka Takai, Daisaku Yano, Ryo Miyake
A compact wireless residual chlorine monitor was developed using a glass mixing and reaction device and an absorbance flowcell. The monitor tracked chlorine concentration changes during the chlorine injection process in a circulating cooling system.
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