RSC - Anal. Methods latest articles

A Luminescent Metal-Organic Polyhedron for Enzyme-Free Detection of Uric Acid

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY01045H, Paper

Wenjing Zhang, Bin Zhao, Weiping Yang, Xiujuan Xu, Wenjuan Zhang, Kai Cui, Chunqiang Yang, Ajuan Yu
Rapid and reliable detection of uric acid (UA) in human biological fluids is important for the early screening and monitoring of metabolic-related diseases. In this work, an enzyme-free fluorescence sensing...
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PdPt Bimetallic Nanozyme-Based Colorimetric Sensor for Sensitive and Label-Free Detection of Gossypol

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00890A, Paper

Yun Wang, Manman Liu, Wenhui Zhang, Qian Zhang, Xiaoling Zhang, Tian Li, Xixi Hou, Suna He
In this work, PdPt bimetallic nanoparticles with robust oxidase-like activity were synthesized, based on which a label-free, H₂O₂-free colorimetric platform was constructed for gossypol detection. The PdPt nanozyme activates dissolved...
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Revisiting biofilms quantification: Crystal Violet Assay and the emerging role of Hyperspectral Imaging

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00772D, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Abhishek Kandikatla, Jitendra Shit, Aala Suresh, Vidhya Das, Sonika Kar, Sunil Chinnadurai, Vazhora Malayil Manikandan, Sarfaraz Hussain, Jayaseelan Murugaiyan
Bacterial biofilms are major contributors to persistent and chronic infections. Conventional methods to quantify biofilm, such as the crystal violet assay, provide only semi-quantitative and non-specific estimates of biomass. In...
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Spatial metabolomics in medicinal plant research: Current advances, technical challenges, and future perspectives

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00572A, Critical Review

Yating Gong, Dongfeng Yang, Zhuoni Hou
Secondary metabolites derived from medicinal plants represent a critical resource for drug discovery and play an indispensable role in the prevention and treatment of major human diseases. Spatial metabolomics has...
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Spectrofluorimetric method for determination of the skin depigmenting substance – 4-hexylresorcinol – in cosmetic products

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY01006G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Marianna Ntorkou, Emmanouela Katzouraki, Vasileios D. Alampanos, Constantinos K. Zacharis
This study reports a rapid and sensitive batch spectrofluorimetric method for the quantification of 4-hexylresorcinol in cosmetic formulations.
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3D-Printed Electrochemical Sensors for Sustainable Electroanalysis: A Critical Assessment of Materials, Green Strategies, and Circular Economy Perspectives

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00757K, Critical Review

Raquel G. Rocha, Lucas V. de Faria, Luiz R. C. Silva, Rafael M. Dornellas, Bruno C. Janegitz, Jéssica Stefano, Diego Pessoa Rocha
Additive manufacturing (AM) has emerged as a powerful strategy for the fabrication of electrochemical sensors, enabling low-cost, miniaturized, and customizable devices with reduced material consumption. Among the available techniques, fused...
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Eco-friendly flow injection amperometric determination of tert-butylhydroquinone in edible oil samples using micelle-mediated reverse-phase dispersive liquid-liquid microextraction and unmodified screen-printed carbon electrode

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY01019A, Paper

Cesar Ricardo Teixeira Tarley, Renata Vieira Conceição, Maikon Thiago do Nascimento, Mayara da Silva Araújo, Roberta Antigo Medeiros, Mariana Gava Segatelli
Lipid oxidation compromises the stability of edible oils, especially refined ones, due to reduced natural antioxidants. Synthetic antioxidants like tert-butylhydroquinone (TBHQ) are widely used but require careful monitoring. This study...
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Silver nanocluster-based nanoprobe for thiram determination in food and environment

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00954A, Communication

Hui Dong, Xin-Ru Sun, Jing Zhu, Wei Wang, Zhong-Xia Wang
A novel silver nanocluster (AgNCs) nanoprobe was prepared using a pyrimidine derivative, 4,6-diamino-2-mercaptopyrimidine, as surface-ligand and reductant for sensitive and selective monitoring of the fungicide thiram (Thi). AgNCs exhibited a...
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Atomic Force Microscopy in Lung Cancer: From Mechanobiology to Clinical Translation

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00786D, Critical Review

Shuwei Wang, Fan Yang, Mengnan Liu
Atomic force microscopy (AFM) enables the nanoscale investigation of cellular mechanics, morphology, and molecular interactions under conditions that closely mimic physiological environments. This review synthesizes AFM analytical methodologies relevant to...
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Emerging Trends in Amino Acid Detection: Wearable Devices and Machine Learning-Assisted Signal Processing

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00596A, Critical Review

Hui Xu, Lican He, Yu Wei, Yanqin Chen, Jian Shu
As critical metabolic biomarkers, amino acids exert essential physiological functions, and their abnormal levels are closely associated with a range of diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions....
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Facile synthesis of diatomic FeSe-NC-900 nanozymes: peroxidase-mimicking activity and colorimetric assay of L-cysteine in real samples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00481D, Paper

Minzi Li, Ke Ye, Tingting Zhao, Hongying Wang, Shaohong Zhang, Zhijuan Wang
A facile and efficient colorimetric method to sensitively detect L-cysteine in real samples using the diatomic FeSe-NC-900 nanozyme was successfully developed.
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From tumors to neurons: mass spectrometry imaging in spatial lipidomics

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00170J, Minireview

Bharath S. Kumar
Lipids are fundamental biomolecules that regulate cellular structure, energy metabolism, and signaling, and their dysregulation is increasingly implicated in the pathogenesis of cancer and neurological disorders.
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Raman mapping as a quantitative tool for the visual analysis of Chinese mineral medicine

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D5AY02099A, Paper

Qian Xu, Jie Chen, Yingmeng Li, Yi Zhou, Yang Jin, Liying Zhang, Shuhu Du
To facilitate the reliable analysis of the inorganic ingredients in Chinese mineral medicine, a validated Raman mapping strategy for assaying aluminum potassium sulfate dodecahydrate (KAl(SO₄)₂·12H₂O) in alumen was reported.
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A smartphone-assisted dual-mode colorimetric sensing system for on-site detection of ciprofloxacin: experimental and DFT insights

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00817H, Paper

Sara M. Ragab, Elhossein A. Moawed, Mohamed M. Aboelnga
The development of portable, cost-effective, and user-friendly analytical tools for one-site detection of ciprofloxacin (CIP) in complex matrices remains a significant challenge.
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AFM-based nanomechanical evaluation of human umbilical cord mesenchymal stem cells for alcohol-associated liver injury

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00703A, Paper

Jinhong Fu, Qiuyang Deng, Jie Jiao, Yujuan Chen, Xiyao Yin, Zuobin Wang
AFM reveals that umbilical cord MSCs protect against alcohol-associated liver injury by restoring cytoskeletal organization, nanomorphology, and mechanical homeostasis in injured hepatocytes.
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Synergistic integration of bidirectional PER and DNAzyme cascades with ZIF-8 quenching for detection of aflatoxin B1

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00837B, Paper

Ziyan Zhao, Yijing Xiao, Chunyuan Huo, Wentong Yu, Shuangyu Meng, Runlong Ma, Zhiqiang Guo, Xinru Ren, Haiping Zhang, Bowen Li, Yu Wang, Su Liu, Jiadong Huang
We have developed an OFF-ON fluorophore sensor that integrates BPER amplification, DNAzyme cleavage and ZIF-8 quenching for AFB1 detection, featuring high specificity and a low detection limit.
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Differential Analysis of Ginseng Methanol Extracts From Different Origins using FTIR and 2D-COS-IR

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00792A, Technical Note

Chen Chen, Haomiao Han, Kunlun Xue, Hongli Zhou, Xing Jin
The quality of ginseng is largely determined by its ginsenoside. However, the high similarity among such extracts poses a considerable challenge to the rapid and differentiation of their origins, which...
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Multimodal spectral fusion for food authenticity and geographical origin traceability: principles, modeling strategies, and application advances

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00650G, Critical Review

Yikang Hou, Zhuoxi Li, Jie Lian
Mechanism-guided multimodal spectral fusion of vibrational, elemental, and spatial signals enables robust food authenticity and geographical-origin traceability when validation is rigorous.
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Direct measurement method for 90Y activity in urine

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00642F, Paper

Yan Ma, Lina Ma, Hui Zhang
Direct measurement of ⁹⁰Y activity in urine can be accurately achieved using both liquid scintillation counting and Cherenkov counting.
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A robust Pt nanozyme for visual isoniazid determination in commercial tablets and biosamples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00345A, Paper

Lili Ai, Qi Zhang, Chenwang Zhang, Zhi Xia, Xiaoxu Cao, Yizhou Xu, Phouphien Keoingthong, Shengkai Li
A reliable method for isoniazid (INH) determination is critical for personalized tuberculosis therapy.
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Application of spraying-based liquid microextraction coupled with gas chromatography-mass spectrometry for the determination of dipropetryn at trace levels in corn flour samples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00447D, Paper

Sezin Erarpat Bodur
An accurate and sensitive analytical method (SB-LPME-GC-MS) was proposed for the determination of dipropetryn at trace levels in corn flour samples.
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A ratiometric fluorescent probe for the detection of peroxynitrite in environmental and plant systems

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00927A, Paper

Xiaoyu Geng, Kanli Wang, Liting Tang, Xiongzhi Wu, Liqiang Yan
A ratiometric probe detects and images ONOO⁻ in water, soil, and plants and supports smartphone test strips for rapid analysis.
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Determination of phenolic compounds in water using excitation–emission fluorescence matrices coupled to multiway calibration strategies

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00658B, Paper

Fengkai Shang, Yaoyao Cui, Li Yuan, Liqin Zhang, Peng Guo, Yuanyuan Yuan
Temperature-assisted four-way EEM fluorescence calibration enables feasible quantification of phenol and thymol in spiked lake water under severe spectral overlap and background interference.
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Unmasked G-quadruplexes for real-time fluorescence detection of viral genomic RNA

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00654J, Paper

Zahra Alkhamis, Fatemeh Javadi-Zarnaghi
Real-time (RT) PCR is currently one of the most powerful molecular approaches for diagnosing infectious diseases. This report combines real time (RT)-PCR with fluorescence detection of viruses via thioflavin interaction with G-quadruplexes.
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On hidden and visible charges in mass spectrometry: Alternative approaches in mass spectra interpretation

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00333H, Tutorial Review

Dimitrios Tsikas
Gas chromatography-mass spectrometry (GC-MS) mass spectra of organic molecules contain ions that are generated in the ion-source of GC-MS apparatus. Electron ionization (EI) generates cations; chemical ionization (CI) generates either...
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Molecularly imprinted polymer-based fluorescent sensors for rapid and specific detection of target pesticides

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00999A, Paper

Haoqi Jia, Rui Li, Xiaoxiao Hong, Xin Dong, Shengxue Ye, Weiwei Li, Jianlin Li, Fenying Wang, Qianjin Li
This study presents a novel fluorescence sensing platform based on molecularly imprinted polymers (MIPs) for the detection of imidacloprid and chlorpyrifos, two widely used pesticides with potential food safety risks....
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Correction: High-performance identification of insulating materials by using generalized spectrum in laser-induced breakdown spectroscopy

Anal. Methods, 2026, 18,5161-5161
DOI: 10.1039/D6AY90069K, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Junfei Nie, Furong Chen, Ting Luo, Jinke Chen, Jiapei Cao, Qiang Huang, Deng Zhang, Zhenlin Hu
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Affinity sensors for L-lactate and lactate dehydrogenase

Anal. Methods, 2026, 18,5000-5012
DOI: 10.1039/D6AY00304D, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Longyu Li, Juewen Liu
This review highlights emerging affinity-based biosensors for L-lactate and lactate dehydrogenase, including aptamers, antibodies, molecularly imprinted polymers as promising alternatives to enzyme-based sensing for stable, cost-effective monitoring.
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Research progress on MOF-based materials for the detection and protection against mustard gas and its simulants

Anal. Methods, 2026, 18,4983-4999
DOI: 10.1039/D6AY00386A, Critical Review

Dan Meng, Jianan Wei, Liu Yang, Shao Min Shuang
Research progress on MOF-based materials for the detection and degradation of mustard gas and its simulants.
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Ultrasensitive SERS-immunochromatographic assay for pesticide detection using core–shell Au@Au nanoparticles: a 103-fold sensitivity boost over LFA

Anal. Methods, 2026, 18,5150-5160
DOI: 10.1039/D6AY00530F, Paper

Wangyu Nan, Fan Sun, Qingdan Ye, Qianmin Dong, Kun Pang, Zihong Ye, Kai Sun, Yufeng Wang, Jie huang, Pei Liang
A Novel Surface-Enhanced Raman Scattering-Based Immunochromatographic Assay (SERS-ICA) for ultrasensitive detection of lambda-cyhalothrin in food samples development, validation, and comparative analysis with conventional lateral flow assay.
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Microfluidic-electrochemical sweat patches for athletes: monitoring lactate, electrolytes, and hydration status

Anal. Methods, 2026, 18,4970-4982
DOI: 10.1039/D6AY00936K, Minireview

Huibo Liu, Wanlei Lin
Microfluidic-electrochemical sweat patches enable real-time athletic monitoring by integrating lactate/electrolyte sensing, sweat handling, scalable fabrication, validation, and data analytics for personalized performance and hydration management.
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Development and validation of LC-MS/MS methods for the quantification of TMS-007, a member of the SMTP congeners, in rat plasma and brain: application to a preclinical pharmacokinetic study

Anal. Methods, 2026, 18,5125-5132
DOI: 10.1039/D6AY00057F, Paper

Yuanbin Hao, Yan Zhang, Huaye Gao, Chenjun Wu, Li Sun, Siqi Zhao, Shaofei Xie, Rong Chen
TMS-007 is a member of the SMTP congeners for the treatment of acute ischemic stroke. LC-MS/MS methods to quantify TMS-007 in various rat matrices were developed. The validated methods were applied to a preclinical study in a tMCAO rat model.
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Portable voltammetric determination of acetaminophen using DropSens-based screen-printed carbon electrodes for clinical and pharmaceutical applications

Anal. Methods, 2026, 18,5074-5085
DOI: 10.1039/D6AY00692B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Rocío Navarro-Utiel, Ana Ballester-Caudet, Sergio Cortés-Bautista, Pilar Campíns-Falcó
The increasing demand for portable, low-cost, and sustainable analytical methodologies has motivated the development of miniaturized electrochemical systems for pharmaceutical and clinical monitoring.
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Single-precursor-derived carbon and nitrogen co-doped CuO nanozymes for colorimetric detection of tetracycline

Anal. Methods, 2026, 18,5133-5140
DOI: 10.1039/D6AY00592F, Paper

Yu Liu, Jingjing Fang, Liangxiao Jiang, Hengchao Yang, Cheng Yao, Chan Song
The carbon and nitrogen co-doped CuO with high peroxidase-like catalytic activity was constructed via direct pyrolysis of copper(II) phthalocyanine (CuPc) as a single source precursor.
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Strain-induced PtCu nanozymes for paper-based portable colorimetric immunoassay of carcinoembryonic antigen with smartphone readout

Anal. Methods, 2026, 18,5034-5040
DOI: 10.1039/D6AY00867D, Paper

Qingliang Lin, Yibin Zeng, Zhichao Yu, Dianping Tang, Xuejing Wu
This work designed a paper-based portable colorimetric immunoassay of carcinoembryonic antigen using strain-induced PtCu bimetallic nanozymes with smartphone readout.
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A rapid, multiplex, one-pot CRISPR/Dx system for visual detection of influenza A, influenza B, and respiratory syncytial viruses

Anal. Methods, 2026, 18,5052-5060
DOI: 10.1039/D6AY00425C, Paper

Qiyuan Xia, Rui Guo, Jianrong Xiao, Lu Zeng, Yumei Huang, Jiahui Li, Xiaoqing Chen, Tingting Huang, Bing Xiao, Chenyu Miao, Weihuang Liu, Qing-Le Liang, Cia-Hin Lau, Haibao Zhu
Multiplex detection of influenza A virus (IAV), influenza B virus (IBV), and respiratory syncytial virus (RSV) with one-pot RT-RPA-CRISPR/Cas12a system.
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A novel bubble rupture sensing methodology for sweat-driven disease diagnostics

Anal. Methods, 2026, 18,5105-5115
DOI: 10.1039/D6AY00583G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Akshay Ajit Parmar, Anoop Kanjirakat, Dolfred Vijay Fernandes, Naresh Kumar Mani
The ionic strength of sweat fluid influences the bubble bursting time.
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Synthesis route attribution of highly toxic ethyl sesquimustard based on non-targeted screening strategy and GC-HRMS

Anal. Methods, 2026, 18,5141-5149
DOI: 10.1039/D6AY00005C, Paper

Yiming Tian, Yixin Gu, Jianfeng Wu, Jia Chen, Jinqiao Jiang, Yulong Liu, Wei You, Kaikai Li, Jianwei Xie
Synthesis route attribution enables accurate source tracing of Q and effective discrimination between distinct synthetic pathways.
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Advancements in plant-based materials for sustainable biomedical applications

Anal. Methods, 2026, 18,5013-5024
DOI: 10.1039/D5AY02086G, Critical Review

Meenakshi Choudhary, Dharmesh Kumar, Penny P. Govender, Sudheesh K. Shukla
Biosensing technologies play a critical role across the healthcare, environmental monitoring, and food safety sectors.
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Automated SPE-GC-MS/MS method for the biomonitoring of eight N-nitrosamines in human urine

Anal. Methods, 2026, 18,5041-5051
DOI: 10.1039/D6AY00432F, Paper

Wanjun Zhang, Run Zhou, Xiangyu Wang, Chao Yang, Chunhua Huang, Xinliang Ding
A highly automated SPE-GC-MS/MS workflow was developed for sensitive biomonitoring of eight N-nitrosamines in human urine using only 4 mL of sample.
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Real-time resonance Raman spectroscopic monitoring of the Briggs–Rauscher reaction

Anal. Methods, 2026, 18,5025-5033
DOI: 10.1039/D6AY00742B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Clark D. Gray, Nigel Gotts, Cassio Lima, Kenneth Williams, Sebastien Maussang, Royston Goodacre
The Briggs–Rauscher reaction is a prototypical oscillating system and is based on chemical mixtures of iodate (IO₃⁻), hydrogen peroxide, malonic acid and Mn²⁺ ions in an acidic solution.
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Microfluidic filtration enrichment cascade nanozyme-catalyzed colorimetric immunoassay for rapid and ultrasensitive detection of Escherichia coli in urine with smartphone readout

Anal. Methods, 2026, 18,5093-5104
DOI: 10.1039/D6AY00597G, Paper

Yuancheng Guo, Tianci Wang, Zhijie Tu, Hong Chen, Shengqi Wang, Guohui Sun, Zhen Rong
Escherichia coli in urine can be efficiently filtration enriched for rapid and ultrasensitive nanozyme-catalyzed colorimetric immunoassay.
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COF hybrid fibrous nano-network aided surface-enhanced Raman scattering assay for epinephrine analysis

Anal. Methods, 2026, 18,5086-5092
DOI: 10.1039/D6AY00679E, Paper

Tianran Yuan, Xueyan Yang, Yinjia Zhao, Longfeng Chu, Liyan Zheng, Xufang Hu, Jing Hu, Qiue Cao
This work presents a novel COF hybrid fibrous nano-network as a SERS-active substrate for epinephrine detection via boronic acid affinity, using citric acid reporter, enabling sensitive, selective, reproducible detection in serum samples.
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The development of aptamer-functionalized streptavidin magnetic particles for sample purification of SARS-CoV-2 coupled with rapid plasmonic RT-qPCR to improve detection sensitivity

Anal. Methods, 2026, 18,5061-5073
DOI: 10.1039/D6AY00498A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Joshua Hayes, Alex Resendes, Seung Soo Lee, Mitra Yousefi, Silvia Vidal, Miltiadis Paliouras, Mark Trifiro
Schematic diagram of the development of an aptamer-based capture methodology for the rapid enrichment and diagnostic sensitivity with plasmonic PCR of SARS-CoV-2.
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Natural deep eutectic solvent-based headspace gas chromatography for determination of 14 residual solvents in tea polyphenol products

Anal. Methods, 2026, 18,5116-5124
DOI: 10.1039/D6AY00418K, Paper

Hengyu Xu, Zheyuan Yao, Xianyu Bao, Yina Cai, Xiaobo Zuo, Chifang Peng
ChCl–glycerol (1 : 2) was screened as the optimal NADES matrix for HS-GC analysis of residual solvents in tea polyphenols. Risk assessment identified benzene as a critical control point, with dichloromethane (HQ 1.47%) also warranting attention.
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Self-Assembled Supramolecular Sensor for Hydrogen Sulfate via Multipoint Hydrogen Bonding: Real-Sample Analysis and Field-Deployable Paper-Based Detection

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00430J, Paper

Nilanjan Dey
Herein, a self-assembled rhodamine–indole based supramolecular probe (compound 1) has been reported for the selective and sensitive detection of hydrogen sulfate (HSO₄⁻) ions in aqueous medium. The probe exhibited aggregation-assisted...
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Ag nanoparticles grown on waste eggshell membrane as an efficient monolithic oxidase mimic for ascorbic acid colorimetric detection

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY01053A, Paper

Qiuxia Deng, Shuang Xiao, Jinyi Xie, Qin Liu, Daiping He, Ping Jiang, Dashui Yuan
Nanozymes act as a promising alternative to natural enzymes in constructing colorimetric sensing platform for biosensing and food analysis, yet most nanozymes are in power form and requires special separation...
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A turn-on fluorescent biosensor based on CdTe quantum dots for sensitive and selective detection of APE1 activity in cervical cancer cell lysates

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00808A, Paper

Xinran Dong, Jingjing Zhang, Weizeyu Liu
Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, and its aberrant activity is closely associated with various cancers, including cervical cancer, as well as neurodegenerative diseases.
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Salt-free in-solution surface-enhanced Raman spectroscopy substrates based on gold nanoparticle-decorated silica spheres

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY01087C, Paper

Huijun Mao, Mark T. McDermott
Noble metal colloidal, such as gold and silver, have been widely used in the SERS analysis as the substrates. The method of narrowing the interparticle distance is a popular subject,...
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A lab-made stencil-printed electrode with silver nanoparticle-modified graphite for the determination of the antibiotic sulfamethoxazole in different real samples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00455E, Paper

Gabriele Santos de Carvalho, Anderson da Silva Pereira, Lucila Aranguina Chiquillan, Wallace Burger Veríssimo de Oliveira, Renato Camargo Matos, Willyam Róger Padilha Barros, Thalles Pedrosa Lisboa
Laboratory-made conductive ink modified with silver nanoparticles serves as a simple, fast, and efficient alternative for the construction of high-performance electrochemical devices and the analysis of real samples.
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Development of a ratiometric N-CDs/RhB fluorescent probe for selective and sensitive detection of arginine and ascorbic acid

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00293E, Paper

Chenyu Qi, Jiayu Zhang, Haiyan Qi, Tao Jing, Jun Li, Rui Jie, Jinzhi Yu
Diagrammatic representation of N-CD and N-CDs/RhB synthesis and the “on–off–on” pattern for the detection of Arg and AA.
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COS-ID-based imprinted polymers with carbohydrate–metal–epitope synergy for selective MMP-9 detection in cancer patient serum

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00486E, Paper

Mei Tian, Xue Dong, Yu Cheng, Miaomiao Zhang, Qian Xu, Zehui Wei, Suhong Wang
COS-ID-based imprinted polymers realize the selective recognition of MMP-9 via synergistic carbohydrate-metal-epitope interactions, exhibiting great potential for cancer serum analysis.
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An all-solid-state potentiometric sensor for dichlorprop based on molecularly imprinted membranes and rGO-modified screen-printed electrodes

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00553E, Paper

Ayman H. Kamel, Hisham S. M. Abd-Rabboh
A highly selective solid-contact ISE for dichlorprop (2,4-DP) determination was developed by combining a molecularly imprinted polymer (MIP) recognition layer with an rGO solid-contact transducer on a screen-printed carbon electrode.
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Development of a Surface-Enhanced Raman Scattering-Based Immunochromatographic Assay for Sensitive Detection of Carbaryl Residues

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00574H, Paper

Xue Wang, Chen Junfei, Chen Yan, Yong Jin, Xiaohua Qi
In this study, a novel tungsten disulfide (WS₂) and gold composite core-shell (WS₂@Au) nanoparticles used to label carbaryl antibody and Raman molecule 5,5-dithiobis-2-nitrobenzoic acid (DTNB) to synthesize Raman immune probes....
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Engineering a Nanocluster-Immobilized MOF@MOF Architecture-Based Ratio Fluorescent Bioassay for Sensing Neurodegenerative Disease-Related Acetylcholinesterase and Inhibitor Drug

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY01083K, Paper

Chao Liu, Jiadi Li, Fengyun Wang, Mengke Wang
Accurate detection of acetylcholinesterase (AChE) activity and screening of its inhibitor drugs are crucial for detecting and intervening in neurodegenerative or aging-associated diseases. Herein, a sensitive and reliable ratiometric fluorescence...
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Recent Advances in Ionic Liquid-Based Microextraction for Pesticide Residue Analysis in Food and Environmental Samples

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00518G, Critical Review

Nikita Barhate, SANTOSH BHUJBAL, Ravindra D Wavhale, Shailendra Shivaji Gurav, Ajay Namdeo, Jaiprakash Sangshetti
Pesticide residues in food and environmental samples remain a global concern for food safety and environmental protection. Conventional extraction methods such as QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe),...
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A Lipid Droplet-Targeted Fluorescent Probe for Selective Imaging of Cysteine Fluctuations in Drug-Induced Liver Injury

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY01001F, Paper

Bin Dai, Xin Jiang, Yu Wu, Ting Yu, Yuan Lv, Haitao Li, Peng Yin
Cysteine (Cys), an essential endogenous biothiol, plays crucial roles in cellular redox homeostasis, metabolic regulation, and detoxification. Abnormal Cys fluctuations are closely associated with various pathological processes, including liver injury....
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A centrifugal microfluidic chip with integrated solid-phase extraction for separation and detection of Cd2+ and Cu2+

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00343E, Paper

Lei Luo, Yuhang Lian, RuiRui Zhu, Shuai Yuan, Mingyong Zhou
An integrated centrifugal chip that incorporates solid-phase extraction (SPE) for the efficient enrichment and subsequent detection of heavy metal ions was developed.
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Wax-printing-free fabrication of paper-supported 3D cancer cell culture

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00724D, Paper

Ankit Kumar, Shweta Kumar, Bhushan J. Toley
Wax-printing-free stacked paper tissues recreate transport limited tumor microenvironments and enable layer-by-layer analysis of cell viability and drug response.
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Development of stabilizing hemoglobin A2 reference materials and assessment of commutability using multiple statistical models

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00644B, Paper

Yanhai Wang, Wei Yang, Yaxin Cao, Mingxue Dong, Na Zhao, Yan Li, Hongying Wang
One of the challenges in developing hemoglobin A₂(HbA₂) reference materials is achieving reliable stability, homogeneity and value transfer capabilities.
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A zirconium-based metal–organic framework (UiO-66) anchored to magnetic graphene oxide as a superior sorbent for the determination of polycyclic aromatic hydrocarbons in water samples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00534A, Paper

Maryam Asefi, Mahtab Eraghi, Amirhassan Amiri, Mehdi Baghayeri
Magnetic graphene oxide modified with UiO-66 (MGO@UiO-66) was used as a sorbent for the extraction of polycyclic aromatic hydrocarbons from real water samples.
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Development of a Microfluidic Paper Analytical Device for the Measurement of Iodide in Briny Wastewater

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00876C, Paper

Mary Harbison, Suzanne Zeff, Jessica Gaetgens, Ahmed Ismail, Kimberley Frederick
Flowback water is a major byproduct of hydraulic fracturing for oil and gas production and is undrinkable because of contamination from radioactive species, trace organic species and high concentrations of...
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Application of FT-IR Spectroscopy as a Non-Invasive Multi-Attribute Monitoring Platform for Critical Quality Attributes in Monoclonal Antibodies

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00620E, Paper

Ameya Parkar, Prajakta Dandekar, Ratnesh Jain
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals widely used to treat cancers, inflammatory, infectious, and autoimmune diseases. The manufacturing of these therapeutics involves multiple complex and time-consuming steps...
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Dual-enhancement lateral flow immunoassay via gold-decorated ferritin nanoprobes and SpyTag/SpyCatcher site-directed conjugation

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00681G, Paper

Xiangyang Yuan, Xingyu Zhu, Yuling Xu, Jianfeng Mei, Shujiang Wu, Bailong Wang, Yu Yi
This dual-enhancement LFIA for hCG integrates gold-ferritin nanoprobes and SpyTag/SpyCatcher site-specific antibody conjugation, achieves a 50-fold sensitivity enhancement (LOD 0.5 mIU per mL), and offers a simple strategy for high-performance POCT.
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Hydrothermal synthesis of Co substituted MnWO4 nanostructures for fluorometric sensing and determination of 4-nitrophenol

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00618C, Paper

Imran Hasan, Fahad Alharthi
MnWO₄ cobalt-substituted nanostructures demonstrated high sensitivity to 4-nitrophenol detection with an ultra-low limit of 9.8 nM.
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A multi-modal lateral flow assay driven by MWCNTs/Fe–N–C for the detection of bisphenol A in lake water

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00643D, Paper

Zhi-Ru Bi, Ming-Hui Shi, Ting-Ting Chen, Yong-Biao Sun, Yu-Rui Zhou, Lin-Jing Wang, Huai-Rong Zhang, Guo-Dong Liu
Bisphenol A (BPA), a prototypical environmental endocrine disruptor with ubiquitous presence in aquatic systems, has prompted significant environmental and public health concerns.
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A centrifugal microfluidic chip for rapid nucleic acid detection of chili pepper viruses

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00848H, Paper

Yan Qing, Hai-Bo Wang, Qin Huang, Qing Liu, Lei Xie, Yi-Mei Wu, Xin Lu, Qun-Ying Zhao, Ya-Jing Dong, Man Li, Ru-Qin Yu, Hao Tang
An integrated, low-cost centrifugal microfluidic chip was developed for the simultaneous detection of six pepper viruses using on-chip dried reagents and real-time fluorescence RT-LAMP.
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Development of a validated UPLC-MS3 method for trace-level azoxystrobin determination in zebrafish liver tissues

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00445H, Paper

Yufeng Guo, Chunpeng Feng, Mengchuan Lai, Meichen Liu, Yalin Xi, Lei Yin, Meiyun Shi
Azoxystrobin, a widely used strobilurin fungicide, exhibits environmental persistence and toxicity to aquatic organisms, necessitating accurate trace-level quantification in biological tissues.
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Development of a colloidal gold immunochromatographic strip for rapid detection of fluoroquinolones in milk

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00727A, Paper

Mengjuan Zhu, Yu Shi, Ming Geng, Xun Zhang, Qinggang Xu
Fluoroquinolones (FQs) are widely used in animal husbandry for the prevention of a variety of animal diseases.
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Recent advances on the recognition of the explosive Mother of Satan: A review

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00584E, Critical Review

Priyanka Sharma, Mainak Ganguly, Ankita Doi, Mamta Sahu
Due to the ease of synthesis and use, improvised explosive devices pose a significant global security threat. Triacetone triperoxide (TATP) is a commonly used peroxide-based explosive with a detonation strength...
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Boronate affinity-based ratiometric fluorescent quantum dot sensors for the rapid detection of streptomycin from food

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00545D, Paper

Yanli Fan, Hengxi Liu, Wanying Geng, Shiping Cang, Daojin Li
Streptomycin (STR), an aminoglycoside-class antibacterial agent, exerts potent antibacterial activity and finds extensive application in veterinary therapeutics and agricultural practices. Nevertheless, the growing improper utilization of STR may lead to...
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Correction: A rapid, multiplex, one-pot CRISPR/Dx system for visual detection of influenza A, influenza B, and respiratory syncytial viruses

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY90076C, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Qiyuan Xia, Rui Guo, Jianrong Xiao, Lu Zeng, Yumei Huang, Jiahui Li, Xiaoqing Chen, Tingting Huang, Bing Xiao, Chenyu Miao, Weihuang Liu, Qing-Le Liang, Cia-Hin Lau, Haibao Zhu
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Supercritical fluid chromatography in food analysis: a survey of the last three-year period

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00698A, Minireview

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Alessia Arena, Marina Russo, Paola Donato, Mariosimone Zoccali, Luigi Mondello
Supercritical fluid chromatography (SFC) has evolved into a versatile, high-performance analytical technique with compelling advantages in food analysis in terms of speed, resolution, and sustainability.
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Development of a green and validated UHPLC-MS/MS method for assessing the pharmacokinetics and safety of PA-PEG12-PA in MCF-7 cells

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00766J, Paper

Jiale Liu, Chuya Wang, Meichen Liu, Jiarui Zhang, Xinyue Zhou, Shuang Feng, Yue Deng, Yalin Xi, Lei Yin, Meiyun Shi
Overview of PA-PEG₁₂-PA: from delivery applications (liposomes, nanoparticles, micelles) and cell assays (toxicity, pharmacokinetics) to UHPLC-MS/MS quantification and greenness data assessment.
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Real-time metered dose inhalers (MDIs) characterization by secondary electrospray ionization (SESI)-mass spectrometry: a proof-of-principle study

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00870D, Technical Note

Ana María Casas-Ferreira, Miguel del Nogal Sánchez, Eliseo Herrero-Hernández, Diego García-Gómez, Encarnación Rodríguez-Gonzalo, José Luis Pérez Pavón
This study explores the application of secondary electrospray ionization mass spectrometry (SESI-MS) for the real-time characterization of pharmaceutical aerosols from metered-dose inhalers (MDIs).
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A low-viscosity hydrophobic deep eutectic solvent based ferrofluid for simultaneous vortex-assisted liquid–liquid microextraction of UV filters and parabens from environmental waters

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00512H, Paper

Kaige Zhang, Yanrong Chen, Jing Wang, Lijun He, Qianchun Zhang
Ferrofluids represent a class of functional materials that combine the flow characteristics of liquids with the magnetic responsiveness of solid magnetic substances.
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Design, synthesis and performance evaluation of a fluorescent probe for the detection of sulfur dioxide in vitro and intracellularly

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00623J, Communication

Lin Li, Ning Zhang, Chao Lu, Dan Qiao, Linqing Wang, Linfei Li, Jian-Yong Wang
In this work, a red-emissive fluorescent probe CouS-CN based on a thiophene-coumarin scaffold was developed for the detection of SO₂.
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An X-ray fluorescence method for direct-on-filter quantification of airborne particulate metals using a handheld analyzer

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00103C, Paper

Orthodoxia Zervaki, Angela Stastny, Ronnee Andrews, Pramod Kulkarni
A handheld XRF instrument in conjunction with CRM-based calibration provides precise, direct-on-filter measurements of airborne metals, enabling swift on-site measurements with detection limits well below the occupational exposure limits.
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Isothermal Amplification Techniques for Rapid Bacterial Detection: Alternatives to Culturing and PCR-Based Methods

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00756B, Critical Review

Léo Baldenweck, Noémie Berg, Mila Djisalov, Vitaly Efremov, Zorica Novakovic, Sandrine Auger, Jasmina Vidic
Rapid identification of bacteria and their virulence factors is essential for global public health. Isothermal amplification has become a cornerstone of point-of-care diagnostics enabling gene testing to be faster, simpler,...
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Ion mobility spectrometry coupled with chemometrics for the rapid identification of six pesticide residues in rice samples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00714G, Paper

Pan Meng, Peng Li, Dairong Ding, Yuqi Gong, Xinyi Guo, Min Sha
The combination method established can simultaneously and rapidly screen multiple pesticide residues with highly similar spectra in rice.
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RSM-optimized automated DI-SPME-GC-MS/MS for multi-class trace plasticizers in drinking water

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00322B, Paper

Ying Zhao, Hongfang Gao, Yixin Liu, Wei Wang, Caixia Wang
An RSM-optimized DI-SPME-GC-MS/MS method was developed for the sensitive, precise, and accurate determination of 29 plasticizers (PAEs and NPPs) in drinking water samples.
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A simple method for quantifying microplastics in water utilizing hydrophobic dyes via ultraviolet-visible spectrophotometry

Anal. Methods, 2026, 18,4937-4949
DOI: 10.1039/D6AY00831C, Paper

Yuechuan Luo, Yiping Li, Bangyan Ou, Ruotong Yang, Guoyu Qiao, Zhenggang Wang
A novel method for the microplastics quantitative detection was developed, based on hydrophobic dye staining and spectrophotometry. The staining process exhibited good linear relationship and anti-interference capability.
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Non-enzymatic electrochemical detection of hemoglobin via analyte-triggered in situ phase transformation of β-Ni(OH)2 nanosheets

Anal. Methods, 2026, 18,4907-4916
DOI: 10.1039/D6AY00617E, Paper

Priya Pathmanathan, Harshit Kale, Shourya Singh Thakur, Madhavan Ramasubramani, A. Gomathi
Haemoglobin (Hb) is the principal diagnostic biomarker for anemia, which affects over one billion people globally and poses a critical public health burden in low- and middle-income countries.
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Metal-free miniaturized flexible electrochemical sensors based on nitrogen-doped carbon black for liquid crystal monomer detection

Anal. Methods, 2026, 18,4887-4897
DOI: 10.1039/D6AY00087H, Paper

Xiuying Li, Zhi Li, Zilong He, Fengyu Li
A miniature, portable detection system based on a flexible electrochemical sensor was developed using metal-free nitrogen-doped carbon black for field detection of liquid crystal monomers.
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A two-stage signal enhancement method integrating the Gaussian mixture model and adaptive rolling ball technique for ultrasensitive fluorescent immunochromatographic detection

Anal. Methods, 2026, 18,4805-4818
DOI: 10.1039/D6AY00496B, Paper

Qian Bian, Chongwen Wang, Wenlong Bai, Liping Dai, Tao Zhang, Qian Wang, Long Zhang, Shuai Zheng, Shu Wang
A portable fluorescence detector with GMM-ARB two-stage enhancement achieves ultrasensitive pathogen detection.
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Hexafluoroisopropanol-induced salt-free catanionic surfactant supramolecular solvent for direct immersion single-drop microextraction of sulfonamides and fluoroquinolones in water samples

Anal. Methods, 2026, 18,4866-4875
DOI: 10.1039/D6AY00449K, Paper

Keke Huang, Jia Chen, Wending Yao, Xiao Li
A homemade DI-SDME holder stabilizes high-density HFIP-induced salt-free catanionic surfactant SUPRAS droplets, enabling simple, sensitive and green trace analysis of sulfonamides and fluoroquinolones in water samples.
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Integration of paper-based DNA extraction with digitized image analysis for colorimetric LAMP-based V. parahaemolyticus detection

Anal. Methods, 2026, 18,4927-4936
DOI: 10.1039/D6AY00702C, Paper

Thi Ngoc Diep Trinh, Nguyen Tran Truc Phuong, Kien Cuong Tran, Kieu The Loan Trinh, Hanh An Nguyen
A novel approach integrating paper-based DNA extraction with digitized image analysis – assisted colorimetric LAMP was developed for colorimetric detection of Vibrio parahaemolyticus.
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An exonuclease III-assisted CHA dual-cycle amplification strategy for quencher-free fluorescent detection of miRNA

Anal. Methods, 2026, 18,4917-4926
DOI: 10.1039/D6AY00629A, Paper

Shi-Qian Liao, Jia-Hao Liu, Xin-Yue Liu, Yi-Ting Liu, Chun-Guang Yang, Zhang-Run Xu
A simple, sensitive, and quencher-free fluorescent method for miRNA detection by combining catalytic hairpin assembly (CHA) with exonuclease III (Exo III)-assisted signal amplification.
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Reaction-induced fluorogenic sensing of benzodiazepines: a 3D-printed smartphone-based device with multivariate RGB optimization

Anal. Methods, 2026, 18,4839-4850
DOI: 10.1039/D6AY00325G, Paper

Thiago Alvares Zamaro de Freitas, Matheus Martins Guedes, Camilla Fonseca Silva, Marcella Matos Cordeiro Borges, Álvaro Cunha Neto, Josefredo Rodriguez Pliego, Cleocir José Dalmaschio, Keyller Bastos Borges
A portable 3D-printed smartphone fluorimetric platform enables benzodiazepine detection with multivariate RGB optimization (MLR: R² = 0.9998), achieving laboratory-grade analytical performance with field-deployable simplicity.
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A pathogen-activated DNAzyme triggers hybridization chain reaction for ultra-sensitive salivary detection of Helicobacter pylori

Anal. Methods, 2026, 18,4795-4804
DOI: 10.1039/D6AY00648E, Paper

Qiming Chen, Quanling Dong, Zhengrong Lu, Zhanmin Liu
Helicobacter pylori infection is a major etiological factor in chronic gastritis, peptic ulcer disease, and gastric cancer, highlighting the demand for sensitive, non-invasive, and operationally simple diagnostic strategies.
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A CHEF-driven fluorescent turn-on probe for sensitive and rapid Al3+ detection in live MDA-MB-231 cells

Anal. Methods, 2026, 18,4858-4865
DOI: 10.1039/D6AY00264A, Paper

Rahul Naskar, Gita Rani Murmu, Subrata Mandal, Rimi Mukherjee, Arpan Halder, Amitav Biswas, Moumita Ghosh, Saswati Gharami, Nabendu Murmu, Tapan K. Mondal
A novel fluorescent switch (PIMB) has been fabricated through a straightforward Schiff base reaction and exhibits highly selective sensing of Al³⁺ over other metal ions at physiological pH.
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Determination of short-chain chlorinated paraffins in carpets by gas chromatography-electron capture negative ionization mass spectrometry

Anal. Methods, 2026, 18,4950-4957
DOI: 10.1039/D6AY00647G, Paper

Ting Gu, Yongli Wu, Lianrui Mei, Yu Zhang, Yi Han
A method based on GC-ECNI-MS was developed for determining short-chain chlorinated paraffins (SCCPs) in carpets, offering data support for global risk control of SCCPs use in carpet products.
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Sweat-based electrochemical wearable biosensors for sports performance and fatigue monitoring: from laboratory prototypes to field deployment

Anal. Methods, 2026, 18,4753-4785
DOI: 10.1039/D6AY00459H, Tutorial Review

Umapathi Krishnamoorthy
Emerging sweat-based wearable biosensors offer non-invasive, continuous assessment of athlete performance, with innovations in sensing, data analytics, and system integration enabling practical deployment beyond laboratory settings.
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Development of a bioluminescent enzyme immunoassay for glycocholic acid based on a single-chain variable fragment-nanoluciferase fusion

Anal. Methods, 2026, 18,4819-4825
DOI: 10.1039/D6AY00731G, Paper

Yunping Mu, Huajian Cai, Xindan Zhang, Mingxia Lin, Junhao Zeng, Yiyun Wang, Ziming Wu, Suqing Zhao, Xiping Cui
As glycocholic acid (GCA) has been recognized as a biomarker for hepatocellular carcinoma (HCC), its detection is crucial for the prevention, diagnosis, and treatment of HCC.
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Stabilization of a ring-opened rhodamine probe via multi-noncovalent interactions for the dual-mode detection of nitazenes

Anal. Methods, 2026, 18,4876-4886
DOI: 10.1039/D6AY00429F, Paper

Yujie Feng, Yudong Li, Bingbing Zhao, Chuanfang Zhao, Jingxiang Li, Luyan Yang, Baiyi Zu, Xincun Dou
Nitazene opioids, representing a potent class of emerging synthetic substances, have emerged as a significant threat to public health and biosafety worldwide.
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Rational design of L-histidine-stabilized fluorescent copper nanoclusters for highly selective and sensitive detection of sunset yellow

Anal. Methods, 2026, 18,4826-4838
DOI: 10.1039/D6AY00800C, Paper

Xingwu Li, Xiaotian Liu, Lili Yuan, Zhengshan Tian
The water-soluble, blue-green fluorescent copper nanoclusters demonstrate exceptional stability in high-temperature and high-salt environments, overcoming the limitations of many fluorescent probes in complex matrices.
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Pheromone measurement using secondary electrospray ionization and portable membrane inlet mass spectrometry

Anal. Methods, 2026, 18,4786-4794
DOI: 10.1039/D6AY00269B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Stamatios Giannoukos, Dimitris Raptopoulos, Maria Konstantopoulou
A secondary electrospray ionization high-resolution mass spectrometry system and a portable membrane inlet mass spectrometer have been used for the first time to detect and monitor insect sex pheromones, both qualitatively and quantitatively.
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Sensitive and reliable Kawasaki disease related microRNA analysis via self-priming chain extension cascades

Anal. Methods, 2026, 18,4898-4906
DOI: 10.1039/D6AY00576D, Paper

Qiuling Huang, Jia Yang
Kawasaki disease (KD) is a leading cause of acquired heart disease in children, requiring timely diagnosis.
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Target-to-signal conversion and spatial enrichment cascade boost CRISPR/Cas12a biosensing for trace-level pathogen detection

Anal. Methods, 2026, 18,4851-4857
DOI: 10.1039/D6AY00441E, Paper

Yu Liu, Xudong Yue, Bowen Li, Haoyu Yang, Yu Wang, Shenguang Ge, Su Liu
A CRISPR/Cas12a-activated DNA nanowire biosensor has been developed for the highly sensitive detection of Salmonella typhimurium.
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Blue Light Enhances Background Current and Dopamine Sensitivity of Carbon-Fiber Microelectrodes During Fast-Scan Cyclic Voltammetry

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00403B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Eric Daniel Donarski, David Robert Luedeka, B. Jill Venton
Electrochemical measurements of neurotransmitters in tissue are often made in conjunction with optogenetic and fluorescent techniques which expose the electrode to light. Recently, our lab observed that light affects the...
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