RSC - Anal. Methods latest articles

Metal-free miniaturized flexible electrochemical sensors based on nitrogen-doped carbon black for liquid crystal monomer detection

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00087H, Paper

Xiuying Li, Zhi Li, Zilong He, Fengyu Li
A miniature, portable detection system based on a flexible electrochemical sensor was developed using metal-free nitrogen-doped carbon black for field detection of liquid crystal monomers.
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Rapid, multiplex, one-pot CRISPR/Dx system for visual detection of influenza A, influenza B, and respiratory syncytial viruses

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00425C, Paper

Qiyuan Xia, Rui Guo, Jianrong Xiao, Lu Zeng, Yumei Huang, Jiahui Li, Xiaoqing Chen, Tingting Huang, Bing Xiao, Chenyu Liao, Weihuang Liu, Qingle Liang, Cia-Hin Lau, Haibao Zhu
The detection of Influenza A virus (IAV), Influenza B virus (IBV), and Respiratory Syncytial Virus (RSV) presents significant diagnostic challenges due to the high similarity of clinical symptoms with other...
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A Novel Bubble Rupture Sensing Methodology for Sweat-Driven Disease Diagnostics

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00583G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Akshay Parmar, Anoop Kanjirakat, Vijay Fernandes, Naresh Kumar Mani
Sweat is a rich biofluid whose composition depends heavily on physiology and varies systematically across a range of systemic and dermatological conditions, making it an attractive medium for non-invasive diagnostics....
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Hexafluoroisopropanol-induced salt-free catanionic surfactant supramolecular solvent for direct immersion single-drop microextraction of sulfonamides and fluoroquinolones in water samples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00449K, Paper

Keke Huang, Jia Chen, Wending Yao, Xiao Li
A homemade DI-SDME holder stabilizes high-density HFIP-induced salt-free catanionic surfactant SUPRAS droplets, enabling simple, sensitive and green trace analysis of sulfonamides and fluoroquinolones in water samples.
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Stabilization of a ring-opened rhodamine probe via multi-noncovalent interactions for the dual-mode detection of nitazenes

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00429F, Paper

Yujie Feng, Yudong Li, Bingbing Zhao, Chuanfang Zhao, Jingxiang Li, Luyan Yang, Baiyi Zu, Xincun Dou
Nitazene opioids, representing a potent class of emerging synthetic substances, have emerged as a significant threat to public health and biosafety worldwide.
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Nanozyme-enhanced lateral flow immunochromatographic tests for the sensitive detection of Francisella tularensis cells in water samples

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00561F, Paper

Nadezhda Byzova, Olga Hendrickson, Vasily G Panferov, Alexey A. Gorbatov, Anton G Shevyakov, Sergey F. Biketov, Anatoly V. Zherdev, Boris B. Dzantiev
Francisella tularensis is a bacterial pathogen that can contaminate drinking water and food products, causing tularemia – a severe zoonotic disease that affects both humans and animals. This infection is...
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Application of surface-enhanced Raman spectroscopy in the diagnosis of infectious diseases

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00691D, Minireview

Lili Tian, Yanxi Li, Tao Wang, Jie Gong, Junbo Han, Jingdong Yuan, Jin Chen, Huiping Zhang, Lihua Qian
Surface-enhanced Raman spectroscopy (SERS) is increasingly emerging as a pivotal analytical technique in the field of clinical diagnostics.
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Synthesis route attribution of highly toxic ethyl sesquimustard based on non-targeted screening strategy and GC-HRMS

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00005C, Paper

Yiming Tian, YiXin Gu, Jianfeng Wu, Jia Chen, Jinqiao Jiang, Yu-Long Liu, Wei You, KaiKai Li, Jianwei Xie
Synthesis route attribution enables accurate source tracing of chemical warfare agents and effective discrimination between distinct synthetic pathways. In the current study, we report for the first time the identification...
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Smartphone Integrated Portable Oxidase-like Hydrogel Kit for UO2 2+ Colorimetric Analysis

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00461J, Paper

Ruotong Liu, Yu Qiao, Zhongke Hu, Dandan Xu, Xiao-Qiong Li, Hang Gao, Bin Liu
Uranyl ion (UO₂²⁺) pollution in marine environments poses a serious threat to human health and aquatic ecosystems. To overcome the dependence of traditional detection methods on large-scale instruments, a portable...
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Advancements of plant-based materials for Sustainable Health Applications

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D5AY02086G, Critical Review

Meenakshi Choudhary, Dharmesh Kumar, Penny P Govender, Sudheesh Shukla
Biosensing technologies play a critical role in various fields, including healthcare, environmental monitoring, and food safety. In-vivo sensing of biomolecules is challenging due to the non-biocompatibility of nano or microelectrodes....
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Automated SPE–GC–MS/MS Method for the Biomonitoring of Eight N-Nitrosamines in Human Urine

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00432F, Paper

Wanjun Zhang, Run Zhou, Xiangyu Wang, Chao Yang, Chunhua Huang, Xinliang Ding
N-nitrosamines (NAms) are potent carcinogenic and mutagenic contaminants that may originate from both exogenous exposure and endogenous nitrosation. Human urine is an important non-invasive matrix for biomonitoring NAms exposure; however,...
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A CHEF-driven fluorescent turn-on probe for sensitive and rapid Al3+ detection in live MDA-MB-231 cells

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00264A, Paper

Rahul Naskar, Gita Rani Murmu, Subrata Mandal, Rimi Mukherjee, Arpan Halder, Amitav Biswas, Moumita Ghosh, Saswati Gharami, Nabendu Murmu, Tapan K. Mondal
A novel fluorescent switch (PIMB) has been fabricated through a straightforward Schiff base reaction and exhibits highly selective sensing of Al³⁺ over other metal ions at physiological pH.
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A new strategy for improving the precision and accuracy of isotope ratio analysis by quadrupole ICP-MS with the optimization of ion beam trajectory

Anal. Methods, 2026, 18,4145-4153
DOI: 10.1039/D6AY00371K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xing Li, Haitao Li, Dingwen Zhang, Xin Yang, Yu Cui, Wei Guo, Lanlan Jin, Shenghong Hu
A new strategy is proposed to improve the accuracy and precision of isotope analysis using ICP-QMS by controlling ion motion trajectories and reducing mass discrimination.
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A magnetic separation-based dual-mode aptasensor integrating FRET fluorescence and UV absorption for early diagnosis of hepatocellular carcinoma

Anal. Methods, 2026, 18,4200-4210
DOI: 10.1039/D6AY00682E, Paper

Jianghua Wang, Jianfeng Tang
Early diagnosis of hepatocellular carcinoma (HCC) is crucial for improving patient survival; however, conventional detection methods using HepG2 cells (a typical HCC cell line) have inherent limitations.
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Construction of viscosity-sensitive RNA fluorescent probes and their application in inflammtation imaging

Anal. Methods, 2026, 18,4189-4199
DOI: 10.1039/D6AY00370B, Paper

Meini Tang, Enxiang Ge, Guofang Li, Dingkun Xiong, Weiying Lin
Abnormal structure or function of the nucleolus can lead to dynamic imbalances in intracellular viscosity, which is a core pathological feature of major diseases, including inflammation and cancer.
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Nanomaterial-enhanced molecular recognition: a Co3O4/TiO2 heterojunction electrochemical sensor for vanillin with experimental and DFT insights

Anal. Methods, 2026, 18,4300-4319
DOI: 10.1039/D6AY00358C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Favour Ezinne Ogulewe, Akeem Adeyemi Oladipo, Mustafa Gazi
A DFT-supported Co₃O₄/TiO₂ heterojunction molecularly imprinted sensor provides highly selective, synergistic electrochemical determination of vanillin in complex food matrices.
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Application of a fluorocarbon chain derived silica as a dispersive solid-phase extraction sorbent for six PAEs in water samples

Anal. Methods, 2026, 18,4183-4188
DOI: 10.1039/D6AY00365F, Paper

Yi-Yang Fang, Hai-Yan Liu, Zhi-Guo Shi
A dispersive solid-phase extraction method was established. And a type of fluorocarbon chain derived silica that can be easily dispersed into water was synthesized. Six PAEs were extracted via polar–polar and hydrophobic interactions.
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Target-to-signal conversion and spatial enrichment cascade boost CRISPR/Cas12a biosensing for trace-level pathogen detection

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00441E, Paper

Yu Liu, Xudong Yue, Bowen Li, Haoyu Yang, Yu Wang, Shenguang Ge, Su Liu
A CRISPR/Cas12a-activated DNA nanowire biosensor has been developed for the highly sensitive detection of Salmonella typhimurium.
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Simple yet sensitive MicroRNA detection using allosteric probe-initiated triple amplification and Cas13a/crRNA-based amplification reaction

Anal. Methods, 2026, 18,4154-4160
DOI: 10.1039/D6AY00578K, Paper

He Chen, Chaonan Zhang
MicroRNAs (miRNAs) have emerged as promising biomarkers for early diagnosis and management of degenerative disc disease (DDD); however, their low abundance and high sequence homology pose significant challenges for clinical detection.
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Fluorescence sensor array integrated with machine learning: robust discrimination of multiple metal ions using carboxyl-rich carbon dots

Anal. Methods, 2026, 18,4133-4144
DOI: 10.1039/D6AY00272B, Paper

Yixiang Li, Weidong Zhang, Da Chen, Xiaobo Sun, Chun Li, Baomin Yang, Jinping Wang
Carboxyl-rich carbon dots combined with six chemically distinct pH 5.0 media generate orthogonal fluorescence fingerprints, enabling machine-learning-assisted discrimination of 15 metal ions and their mixtures in complex environmental samples.
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Analytical workflows in salivary metabolomics for athlete stress monitoring: sampling, platform selection, and translation challenges

Anal. Methods, 2026, 18,4111-4132
DOI: 10.1039/D6AY00755D, Minireview

Fei Liu, Xiaotian Gao, Xiaoping Wang, Song Yuan, Chan Wang
Salivary metabolomics offers a low-burden biochemical layer for athlete monitoring, but translation requires standardized analytical workflows suitable for repeated real-world use.
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Simultaneous determination of eight cannabinoids in hemp-based dietary supplements via an optimized SE-HPLC-PDA workflow integrating chemometric evaluation

Anal. Methods, 2026, 18,4171-4182
DOI: 10.1039/D6AY00387G, Paper

Radosław Porada, Monika Wójcik, Małgorzata Herman, Wojciech Piekoszewski
The growing availability of hemp-based dietary supplements requires improvement of analytical methods and sample preparation for quality control of such products.
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Quantification of multi-volatile compounds in cooked rice by using headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry

Anal. Methods, 2026, 18,4289-4299
DOI: 10.1039/D6AY00201C, Paper

Xianqiao Hu, Shuimei Li, Lin Lu, Weixing Zhang, Linping Zhang, Mingxue Chen
Quantification of multiple volatile compounds in cooked rice was performed using HS-SPME-GC-MS. Standard addition was used to eliminate the matrix effect, and a reference compound was introduced to improve the linearity of the calibration curve.
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A molecular-imprinted SERS sensor based on a silver substrate for the selective capture and sensitive detection of crystal violet in textile wastewater

Anal. Methods, 2026, 18,4277-4288
DOI: 10.1039/D6AY00255B, Paper

Xiaohui Ren, Kailai Zhang, Jiaying Dou, Fei Xue, Xinyu Liu, Chenhui Yin, Wenjie Ma
The ploymerization, eluting and rebinding process of Ag@MIPs.
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Chemical derivatization of citrullinated peptides using methylglyoxal and sodium 3-mercaptopropanesulfonate (MG/MPS)

Anal. Methods, 2026, 18,4320-4330
DOI: 10.1039/D6AY00547K, Paper

Yunxia Wang, Juanjuan Zhao, Shan Zhang, Ying Wang, Zhibo Jin, Xingtai Qiu, Zichao Tang, Nan Deng, Yangyang Bian
A novel MG/MPS derivatization strategy is established for highly specific and sensitive analysis of protein citrullination by mass spectrometry.
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A quinoxaline-based conjugated microporous polymer-coating for solid phase microextraction of polycyclic aromatic hydrocarbons in environmental samples

Anal. Methods, 2026, 18,4236-4248
DOI: 10.1039/D6AY00360E, Paper

Gang Xiang, Liushi Xu, Zheng Li, Fengping Liu, Huan Lian, Cuizhong Zhang, Jing Sun, Jinyun Peng, Yunyu Li
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants with severe ecological toxicity, released via both biogenic and anthropogenic pathways.
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Development and validation of a cross-species breath metabolomics platform for translational VOC analysis

Anal. Methods, 2026, 18,4263-4276
DOI: 10.1039/D6AY00164E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Zhiheng Yu, Yongyan Ji, Zijun Meng, Xiang Li
A validated cross-species breath metabolomics platform enables transferable VOC discovery from human studies to animal model verification.
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Single-probe cascade determination of multiple analytes by a tandem reaction of copper nanoclusters

Anal. Methods, 2026, 18,4211-4216
DOI: 10.1039/D6AY00117C, Paper

Bo Zhao, Huijun Zhang, Liuyang Wang, Weiping Chen, Liping Fang, Xinwu Ba, Libin Bai
Fluorescent and colorimetric dual-channel determination of hyperoxide and R-COOH by a tandem reaction of copper nanoclusters.
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A ratiometric fluorescence sensor based on a bifunctional Cu-MOF nanozyme for dual-signal detection of glyphosate in actual samples

Anal. Methods, 2026, 18,4161-4170
DOI: 10.1039/D6AY00220J, Paper

Yubo Zhang, Chao Liu, Huihui Ge, Tianyi Zheng, Jianhua Wang, Yaoyong Wang
Schematic diagram of dual-function nanozyme detection of GLY.
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Digital image method based on a smartphone assisted by hydrophobic natural deep eutectic solvent for iron quantification in dietary supplements

Anal. Methods, 2026, 18,4249-4262
DOI: 10.1039/D6AY00456C, Paper

Gabriel Bercley de Lima Vitorino, Jackson Rodrigo dos Santos Silva, Vinícius de Alcântara Carvalho, João Paulo Barbosa de Almeida, Willian Toito Suarez, Severino Carlos Bezerra de Oliveira, Vagner Bezerra dos Santos
Extraction and detection of iron from supplementary materials using natural deep eutectic solvents and the digital image method.
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Rapid identification of chemical constituents of Liaogu formula based on UHPLC-Q-TOF-MSE combined with the UNIFI platform

Anal. Methods, 2026, 18,4217-4235
DOI: 10.1039/D5AY02031J, Paper

Xin Li, Caiying Liu, Liqi Ng, Qiujia Yu, Yingtao Bai, Yu Zhou
Chemical components of Liaogu Formula (LGF) were analysed using ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry (UHPLC-Q-TOF-MS^E) combined with the UNIFI platform.
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Ion exchange enables Maldi-Tof mass spectrometry analysis for sequence-controlled polymers with positively charged backbone

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00324A, Paper

Bo Zhao, Shengying Cai, Chao Gao
Transforming negative ions of cationic polymers with positively charged backbone into Tf2N-((SO2CF3)2N-) or FSI-((SO2F)2N-) through an ion exchange reaction makes it possible to achieve the matrix-assisted laser desorption ionization-time of...
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A two-stage signal enhancement method integrating the Gaussian mixture model and adaptive rolling ball technique for ultrasensitive fluorescent immunochromatographic detection

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00496B, Paper

Qian Bian, Chongwen Wang, Wenlong Bai, Liping Dai, Tao Zhang, Qian Wang, Long Zhang, Shuai Zheng, Shu Wang
A portable fluorescence detector with GMM-ARB two-stage enhancement achieves ultrasensitive pathogen detection.
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Real-Time Resonance Raman Spectroscopic Monitoring of the Briggs-Rauscher Reaction

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00742B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Clark Gray, Kenneth Williams, Nigel Gotts, Cássio Lima, Sebastien Maussang, Royston Goodacre
The Briggs-Rauscher reaction is a prototypical oscillating system and is based on chemical mixtures of iodate (IO₃^-), hydrogen peroxide, malonic acid and Mn²⁺ ions in an acidic solution. Although the...
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Recent advances in microfluidic technologies for circulating tumor cell isolation: from separation strategies to clinical translation

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00687F, Critical Review

Chentao Li, Jialuo Cheng, Dingfu Zhao, Rui Cao, Yinglin Wang, Siyuan Zhao, DeZhi Li, Qing Liu
Circulating tumor cells (CTCs) are promising liquid-biopsy biomarkers for cancer diagnosis, treatment monitoring, metastasis assessment, and precision therapy. However, their clinical utility is constrained by extreme rarity, pronounced heterogeneity, and...
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Reaction-induced fluorogenic sensing of benzodiazepines: a 3D-printed smartphone-based device with multivariate RGB optimization

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00325G, Paper

Thiago Alvares Zamaro de Freitas, Matheus Martins Guedes, Camilla Fonseca Silva, Marcella Matos Cordeiro Borges, Álvaro Cunha Neto, Josefredo Rodriguez Pliego, Cleocir José Dalmaschio, Keyller Bastos Borges
A portable 3D-printed smartphone fluorimetric platform enables benzodiazepine detection with multivariate RGB optimization (MLR: R² = 0.9998), achieving laboratory-grade analytical performance with field-deployable simplicity.
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A pathogen-activated DNAzyme triggers hybridization chain reaction for ultra-sensitive salivary detection of Helicobacter pylori

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00648E, Paper

Qiming Chen, Quanling Dong, Zhengrong Lu, Zhanmin Liu
Helicobacter pylori infection is a major etiological factor in chronic gastritis, peptic ulcer disease, and gastric cancer, highlighting the demand for sensitive, non-invasive, and operationally simple diagnostic strategies.
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Development of a bioluminescent enzyme immunoassay for glycocholic acid based on a single-chain variable fragment-nanoluciferase fusion

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00731G, Paper

Yunping Mu, Huajian Cai, Xindan Zhang, Mingxia Lin, Junhao Zeng, Yiyun Wang, Ziming Wu, Suqing Zhao, Xiping Cui
As glycocholic acid (GCA) has been recognized as a biomarker for hepatocellular carcinoma (HCC), its detection is crucial for the prevention, diagnosis, and treatment of HCC.
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Rational design of L-histidine-stabilized fluorescent copper nanoclusters for highly selective and sensitive detection of sunset yellow

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00800C, Paper

Xingwu Li, Xiaotian Liu, Lili Yuan, Zhengshan Tian
The water-soluble, blue-green fluorescent copper nanoclusters demonstrate exceptional stability in high-temperature and high-salt environments, overcoming the limitations of many fluorescent probes in complex matrices.
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Mahonia-Derived Carbon Dots for Dual-Ion Ratiometric Sensing and Cellular Bioimaging

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00783J, Paper

Shuo Yang, Qiushu Chen, Manshan Liang, Shangheng Huang, Yuli Mei, Kaisong Yuan, Shengfeng Huang, Yang Huang
The presence of hexavalent chromium (Cr6+) and silver ions (Ag+) in pharmaceutical systems poses significant safety concerns due to their toxicity and bioaccumulation potential. Therefore, the development of rapid, reliable,...
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Smart dual-wavelength UV-vis spectroscopic method and smartphone-based RGB method for the rapid quantification of pyronaridine tetraphosphate: integration with the SDG approach

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00052E, Paper

Jenish H. Parekh, Abhishek Munjapara, Bhavesh N. Socha, Subrata Patra, Hetal Jebaliya
This study demonstrates the quantification of pyronaridine tetraphosphate using UV-Vis spectroscopy and a smartphone-based method with the integration of an SDG approach.
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A nitrogen-doped carbon dot fluorescent probe for sensitive detection of metronidazole in pharmaceutical samples and evaluation of its cytotoxicity and cell imaging performance

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00354K, Paper

Jiahui Li, Jingui Zhong, Hanyan Wei, Hongyan Bai
Metronidazole (MTZ) is a widely used nitroimidazole antibiotic, and its excessive use may pose health risks.
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Iodine-starch reaction renewed: determination of iodate in table salts via the lab-in-syringe technique

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00438E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Cemre Yıldız, Ivana H. Šrámková, Sercan Yıldırım, Petr Solich, Burkhard Horstkotte
A novel in-syringe automated method was developed for simple, sensitive, and green determination of iodate in table salts.
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Recovery of TNT from post-blast soil samples: effects of soil type, extraction methodology, and storage conditions

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00563B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

A. J. Hecker, H. Upadhyaya, J. V. Goodpaster
Traditionally, determination of explosives and their decomposition products in soil samples involves a 24-hour ultrasonic solid–liquid extraction (SLE) using acetonitrile followed by a “salting out” liquid–liquid extraction (LLE).
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A polymer-integrated flexible gold nanotriangle array for quantitative and nondestructive SERS detection of thiram on apples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00537C, Paper

Ze-Bo Zheng, Xiao-Hui Sun, Wan-Hui Guo, Wen Pan, Fan-Li Zhang, Sheng-Hong Liu
Polymer-integrated flexible SERS platform for nondestructive detection on non-planar food surfaces.
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A zwitterionic-enabled one-pot electrochemical strategy for stable end-point detection of isothermal nucleic acid amplification

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00543H, Paper

Yijie Wang, Yang Li, Jiufa Zhang, Mingjun Cai, Qi Fu, Xiaohan Lin, Cuiping Ma, Chao Shi
A zwitterionic EC-LAMP strategy enables stable end-point electrochemical detection of isothermal nucleic acid amplification by reducing interfacial fouling.
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Direct inlet probe mass spectrometry with wavelength selective resonance enhanced photo ionisation

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00377J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Fabian Etscheidt, Philip Jürß, Christopher P. Rüger, Ralf Zimmermann
We demonstrate a wavelength-selective atmospheric-pressure laser ionisation (APLI) workflow for direct inlet probe (DIP) evolved-gas analysis with ultra-high-resolution mass spectrometric detection.
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Responsive red carbon dots with dual-wavelength emission for anti-counterfeiting

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00700G, Communication

Jingjing Chen, Kaiqing Wu, Mengyi Xi, Jinpeng Cai, Ran Chen, Yanfei Shen, Songqin Liu, Yuanjian Zhang
An anti-counterfeiting strategy based on a hidden spectral switch within red fluorescence is presented, offering a concealed mechanism that fundamentally enhances forgery resistance by maintaining visual constancy under external stimuli.
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Analytical method development for multiresidue determination in water using automated parallel dispersive pipette extraction and HPLC-DAD

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00396F, Paper

João Pedro Ossucci Martins, Augusto Bortolotto, Francielle Crocetta Turazzi, Lucas Morés, Eduardo Carasek
This work presents an automated parallel dispersive pipette extraction (Au-Pa-DPX) technique for analyzing nine organic compounds from different classes in river water.
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Research on a highly sensitive aptamer sensor for Vibrio alginolyticus based on CRISPR-Cas13a and T7 transcription cascade amplification

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00035E, Paper

Yukun Zhao, He Sun, Yue Wan, Zebin Zhang, Lingyi Xiao, Tingting Han, Zhuo Hao, Nan Li, Chunying Pang, Wenhui Zhang, Jiayu Wan
An aptamer-CRISPR/Cas13a biosensor for ultrasensitive detection of Vibrio alginolyticus in food safety.
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Recombinase polymerase amplification via proximity hybridization-triggered amplification conversion for detecting diverse nucleic acid targets

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00342G, Paper

Lutan Zhang, Yuxiao Ma, Wenbo Wang, Jian Zhang, Yixi Zhou, Yanru Huang, Xingmei Yao, Lulu Xu, Yunsheng Ge
Versatile recombinase polymerase amplification via proximity hybridization-triggered amplification conversion for detecting diverse nucleic acid targets with great sensitivity and specificity.
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A high-performance nanohybrid impedimetric platform for early cancer detection via c-Myc oncoprotein sensing

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D5AY01872B, Paper

Diptirekha Mohanta, Urmila Saxena
An electrochemical nanohybrid immunosensor integrating N-doped MWCNTs and AgNPs enables ultra-sensitive, stable, point-of-care detection of Myc oncogene.
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Integration of Paper-Based DNA Extraction with Digitized Image Analysis for Colorimetric LAMP-Based V. parahaemolyticus Detection

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00702C, Paper

Thi Ngoc Diep Trinh, Nguyen Tran Truc Phuong, Kien Cuong Tran, Kieu The Loan Trinh, Hanh An Nguyen
Vibrio parahaemolyticus contamination in seafood is a major contributor to foodborne illness and poses significant public health risks, particularly in regions where seafood is consumed raw or minimally cooked. Although...
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Ratiometric Fluorescent Detection of Phosgene in Liquid and Gas Phases Using a Tautomeric Dye: A Combined Experimental and Theoretical Study

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00519E, Paper

Afna Ummer, Avijit Kumar Das, Malavika S. Kumar, Urmila Saha, Malay Dolai
A new fluorescent probe, designated as ((E)-2-((2-hydroxy-3-methoxybenzylidene)amino)-2-(hydroxymethyl)propane-1,3-diol (HHP), was synthesized for selective detection of phosgene via a fluorescence-based cyclization mechanism. Initially HHP exhibits high fluorescence with a strong emission signal...
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An exonuclease III-assisted CHA dual-cycle amplification strategy for quencher-free fluorescent detection of miRNA

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00629A, Paper

Shi-Qian Liao, Jia-Hao Liu, Xin-Yue Liu, Yi-Ting Liu, Chunguang Yang, Zhangrun Xu
MicroRNAs (miRNAs) are crucial biomarkers for cancer diagnosis, but their detection is challenged by low abundance and sequence homology. Herein, we report a simple, sensitive, and quencher-free fluorescent method for...
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X-Ray Fluorescence Method for Direct–on–Filter quantification of Airborne Particulate Metals using a Handheld Analyzer

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00103C, Paper

ORTHODOXIA ZERVAKI, Angela Stastny, Ronnee Andrews, Pramod Kulkarni
The expansion of industrial sectors dependent on welding processes has intensified concerns regarding occupational exposure to metal and metal oxide aerosols. This study presents a direct-on-filter method for quantifying airborne...
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Bagging partial least squares for accurate and stable wheat protein content detection using near-infrared spectroscopy

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00743K, Paper

Qingxiao Ma, Longyan Zhang, Yongfeng Ju, Guoao Xie, Feiming Li
Near-infrared (NIR) spectroscopy combined with machine learning algorithms has been widely adopted for rapid assessment of grain quality attributes. However, conventional calibration models often suffer from overfitting and instability when...
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Sensitive detection and prostate cancer cellular evaluation of sarcosine via a fluorescence turn-on assay using an N-CQDs/Ag+ nanosensor

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00357E, Paper

Xinyu Shen, Suli He, Lezhong Qi, Xiayong Jing, Xinqiang Gan, Xingjun He
Sarcosine, a key oncometabolite in prostate cancer (PCa), has emerged as a promising biomarker for disease diagnosis and progression monitoring.
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Engineering Fluorine and Nitrogen Co-doped magnetic Organic Polymers to Enrich and Detect Amphetamine-type Stimulants

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00338A, Paper

Ma Juanjuan, Zhaozhou li, Huawei Niu, Wenfen Zhang
The development of sensitive, accurate methods for detecting amphetamine-type stimulants (ATS) has become increasingly urgent, driven by the pressing need to protect human health and environmental safety. However, achieving efficient,...
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Simultaneous measurement of piperacillin, tazobactam and meropenem in patient samples using LC-MS/MS to support β-lactam therapeutic drug monitoring

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00331A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Stefania Federico, Suzy Williams, Richard C. Wilson, Paul Arkel, Mark J. Gilchrist, Alison H. Holmes, Timothy M. Rawson, Alaa Riezk
A highly sensitive LC-MS/MS method (LLOQ 0.02 mg L⁻¹) enables simultaneous quantification of piperacillin, tazobactam and meropenem for therapeutic drug monitoring in critically ill patients.
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Preparation of nanoflower-based loaded dual nanozymes and their application in colorimetric detection of uric acid in urine

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00505E, Paper

Junping Yang, Ziyu Song, Lu Huang, Ke Wen, Yuan Lu, Qian Liu
A one-pot bio-inspired synthesis approach was employed to fabricate five types of uricase nanoflowers (UOx-NFs), from which Mn-UOx-NFs with the highest catalytic activity were selected.
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Au@Pt core–shell nanoparticle-based lateral flow immunoassay for rapid detection of Porphyromonas gingivalis type II and IV FimA

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00298F, Paper

Junheng Chen, Zhenjie Lu, Xiaojun Wang, Fan Cheng, Xudong Wang, Fang Li, Min Li, Yingfu Zhang, Yunlong Wang
Au@Pt core–shell nanoparticle-based lateral flow immunoassay enables 14 min visual detection of Pg FimA II/IV with high clinical concordance for rapid identification of high-virulence periodontal infections.
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Detection of kanamycin residues in animal-derived foods using a homogeneous AlphaLICA immunoassay

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00383D, Paper

Dian Li, Shangbin Kao, Yuan Qin, Xiumei Zhou, Xueqin Zhao, Yun Chen, Biao Huang
This homogeneous Kana-AlphaLICA assay enables highly sensitive detection of kanamycin residues in milk and honey within 15 min, providing a rapid tool for high-throughput food safety screening of dairy and apiculture products.
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High-frequency ammonium monitoring in coastal seawater via a flow-batch system featuring a heating reaction coil

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00478D, Technical Note

Fanrong Zeng, Kunning Lin, Yuanbiao Zhang
Ammonium (NH₄⁺) is a critical nutrient in marine ecosystems, and its high-frequency monitoring is essential for understanding dynamic biogeochemical processes.
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Rapid and convenient electrochemical hemoglobin detection in mouse feces employing a DNA aptamer to evaluate the severity of colitis in a mouse model

Anal. Methods, 2026, 18,3924-3927
DOI: 10.1039/D6AY00278A, Communication

Mizuki Nakashima, Daimei Miura, Erika Komiya, Nanami Watanabe, Kaori Tsukakoshi, Tsutomu Omatsu, Wakako Tsugawa, Koji Sode, Kazunori Ikebukuro, Toshinori Yoshida, Ryutaro Asano
Mouse hemoglobin in mouse feces was quantified in 20 min using an aptamer cross-reactive with human hemoglobin.
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SERS-based detection of pesticide residues in food: substrate fabrication, optimization, and applications

Anal. Methods, 2026, 18,3901-3923
DOI: 10.1039/D6AY00408C, Critical Review

Yuhang Que, Ling Xin, Lingyao Zhu, Li Wang, Zhuang Li
This work reviews SERS substrate preparation and optimization strategies, and recent advances (2020-present) in SERS for pesticide residue detection in food, including principles, adaptation strategies, advantages, limitations, and solutions.
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Analytical evaluation and mechanistic elucidation of the Co3O4/biochar composite-activated peroxymonosulfate system for efficient tetracycline degradation

Anal. Methods, 2026, 18,4048-4063
DOI: 10.1039/D6AY00305B, Paper

Eman A. Alabdullkarem, Gullola Karamatova, Tanjina Nasrin Tamin, Dilrabo Kodirova, Hossam S. El-Beltagi, Muhammad Jamshaid
The objective of this study was to develop a highly efficient biochar-supported Co₃O₄ (Co₃O₄/BC) composite catalyst and assess its synergistic performance in conjunction with PMS for the effective degradation of TC antibiotics.
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Construction of a mito-targeting fluorescent probe for specific identification of Al3+ in environmental and biological systems

Anal. Methods, 2026, 18,3999-4011
DOI: 10.1039/D6AY00315J, Paper

Guiying Hu, Aoshanshan Fan, Yanfei Qin, Wen Qin, Zhiyong Xing, Liangping Li
A benzothiazole-based HMH-Al was developed for Al³⁺ sensing. It exhibits a distinct turn-on response with a detection limit of 2.83 × 10⁻⁷ M. HMH-Al was applied in real water samples, test strips, and fluorescence imaging in living cells.
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PolyA-tail-mediated assembly of a gold nanoparticle-based turn-on fluorescent aptasensor for ultrasensitive detection of perfluorooctanoic acid

Anal. Methods, 2026, 18,3928-3932
DOI: 10.1039/D6AY00236F, Communication

Zhuo-Ying Li, Li-Xia Yan, Xu Zhao, Hua Lin, Li-Jian Chen, Xiu-Ping Yan
A turn-on fluorescent aptasensor enables ultrasensitive PFOA detection via a polyA-aptamer anchored AuNP-based FRET strategy, validated in spiked fish samples.
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Quartz crystal microbalance determination of acephate based on a molecularly imprinted polymer and sulphur-doped copper ferrites

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00590J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Bahar Bankoğlu Yola
Acephate (ACE), an effective systemic insecticide, plays a significant role in agricultural pest control.
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A green analytical assay for the quantitation of bioavailable phosphorus in soils: in situ extraction and smartphone-based measurement

Anal. Methods, 2026, 18,3933-3943
DOI: 10.1039/D6AY00101G, Paper

Stella Sales Macedo, Edilene Cristina Ferreira, Arnaldo Alves Cardoso
A sustainable method for quantifying bioavailable phosphorus in soils using ultrasound-assisted extraction and smartphone-based digital image colorimetry, enabling rapid and portable analysis.
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An ion chromatographic method for the purity analysis of the poorly soluble energetic coordination compound lead NTOate

Anal. Methods, 2026, 18,4040-4047
DOI: 10.1039/D6AY00475J, Paper

Fengyi Xia, Jiexin He, Dongxu Zhang, Ji-Min Han, Li Yang
An ion chromatography (IC) method was developed for the purity determination of the poorly soluble energetic coordination compound lead NTOate (lead(II) salt of 3-nitro-1,2,4-triazol-5-one).
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Electrochemically amplified nanozymatic activity of biolinker-based Co-MOF for H2O2 and dopamine detection

Anal. Methods, 2026, 18,4089-4099
DOI: 10.1039/D6AY00361C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jasmine Look, Syed Rahin Ahmed, Mohamed Hassan Mahana, Md. Shalauddin, Shamima Akhter, Wan Jefrey Basirun, Seshasai Srinivasan, Amin Reza Rajabzadeh
Synthesis of redox-active Co-MOF and application of electro-assisted nanozymatic detection of H₂O₂ and dopamine.
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Unveiling the geographical signature of black tea through UHPLC-quadrupole-Orbitrap Exploris HRMS analysis

Anal. Methods, 2026, 18,3979-3998
DOI: 10.1039/D6AY00096G, Paper

Subodh Kumar Budakoti, Khalid Anwar, Nagendla Narendra Kumar, M. L. Anirudh Bhat, Dasharath Oulkar, Pratibha Sharma
Understanding the geographical differentiation of black tea is essential for exploring the influence of territory on its chemical composition.
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On-line gas diffusion membrane separation-flow injection analysis with spectrophotometric detection for the automated determination of ammonia nitrogen in complex industrial wastewater

Anal. Methods, 2026, 18,4012-4020
DOI: 10.1039/D6AY00656F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jun Hu, Rui Huang, Peng Li, Yanli Hua, Kunde Lin
An automated online gas diffusion membrane separation coupled with flow injection analysis and salicylate spectrophotometric detection was developed for the rapid determination of NH₃–N in complex industrial wastewater.
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A portable near-infrared aptasensor platform for derivatization-assisted on-site analysis of acrylamide in food samples

Anal. Methods, 2026, 18,4079-4088
DOI: 10.1039/D6AY00267F, Paper

Lingli Bu, Meixing Liu, Qihang Yang, Xinkai Li, Minglei Li, Luyao Li, Song Wang, Sheng Lei, Jiaheng Zhang
A near-infrared fluorescent aptasensor based on TICT modulation was developed for sensitive detection of acrylamide via its xanthydrol-derived adduct, enabling rapid and reliable analysis in complex food samples.
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Self-amplifying cascade-triggered Au NP assembly strategy for ultrasensitive cTnI detection with dynamic light scattering

Anal. Methods, 2026, 18,4021-4029
DOI: 10.1039/D6AY00491A, Paper

Chen Chen, Yingqing Li, Xiaosong Yang, Liansheng Ling, Ji Zhang
We report a DLS-based cascade immunosensor for cTnI that coupled glucose oxidase and Fe-MOF to produce ˙OH radicals, cleaving DNA on AuNPs and triggering salt-induced aggregation for high-sensitivity detection.
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Engineering a nanobody–alkaline phosphatase bifunctional probe for enhanced immunoassay performance toward microcystin-LR

Anal. Methods, 2026, 18,3944-3952
DOI: 10.1039/D6AY00556J, Paper

Yingying Ma, Tong Ai, Xinyi Chen, Rui Zhang, Ruoyu Li, Hanlin Jin, Yurun Pei, Peng Liu, Jie Luo, Qi Chen
A2.3-AP, an MC-LR-specific nanobody-AP fusion probe, showed 44-fold higher avidity, enabled one-step IC-ELISA, and greatly improved detection speed and sensitivity.
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Preparation of MIL-68@Fe3O4@PVDF composites via the spray phase inversion method and their magnetic solid-phase extraction of parabens and bisphenol A

Anal. Methods, 2026, 18,3953-3965
DOI: 10.1039/D6AY00276E, Paper

Xinwen Hu, Yong Zhang, Zhihao Chen, Mengqian Xiao, Litao Wang, Guihua Gao
MIL-68@Fe₃O₄@PVDF composites were prepared by the spray phase inversion method and used for MSPE of parabens and BPA.
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Development and validation of a QbD-integrated sensitive RP-HPLC method for quantitation of fenofibrate: an application in quality control

Anal. Methods, 2026, 18,4064-4078
DOI: 10.1039/D5AY01843A, Paper

Romi Singh, Abhiram Kumar, Ashutosh Pareek, Dipti Srivastava, Madhaw Kumar, Mohini Chaurasia, S. J. S. Flora
The present study aims to develop and validate a robust, sensitive HPLC method for the estimation of fenofibrate in a gel-matrix sustained-release tablet formulation designed to prevent alcohol-induced dose dumping.
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A ratiometric fluorescence/colorimetric dual-response sensor based on fluorescent nanozymes and smartphone-assisted readout for the accurate determination of glyphosate residues

Anal. Methods, 2026, 18,3966-3978
DOI: 10.1039/D6AY00379F, Paper

Xuhai Ding, Ying Zhang, Tao Bo, Jinhua Zhang, Wenyan Yan, Baoqing Bai, Yukun Yang
A Cu-BH MOF nanozyme-based fluorescence/colorimetric dual-response sensor for visual glyphosate detection with ultra-low limits via smartphone RGB readout.
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Development and prospects of fluorescence polarization immunoassay for pesticide detection in food and environment

Anal. Methods, 2026, 18,3885-3900
DOI: 10.1039/D6AY00409A, Critical Review

Weiguo Yu, Zhenjiang Liu
FPIA is a detection technique derived from Perrin's equation. It is advanced through tracer and recognition element design. Integration with modern analytical methods is recommended.
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Unsupervised and supervised methodologies for identification of sample pixels in Fourier transform infrared microspectroscopic images

Anal. Methods, 2026, 18,4030-4039
DOI: 10.1039/D5AY02095F, Paper

Xiangyu Zhao, Yudong Tian, Jingzhu Shao, Chongzhao Wu
A framework combining unsupervised and supervised methods is presented for sample pixel identification in FTIR microspectroscopy. This integrated solution ensures accurate detection and streamlines FTIR signal processing for further applications.
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Environmentally friendly electrochemical and spectrophotometric strategies for sensitive determination of nintedanib in complex matrices

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00589F, Paper

Özgür Üstündağ, Marwah Naser, Wiem Bouali, Nevin Erk
Precise quantification of nintedanib (NIN) is essential due to its widespread clinical use and the need for reliable quality control in pharmaceutical and biological samples.
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Microfluidic Filtration Enrichment Cascade Nanozyme-Catalyzed Colorimetric Immunoassay for Rapid and Ultrasensitive Detection of Escherichia coli in Urine with Smartphone Readout

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00597G, Paper

Yuancheng Guo, Tianci Wang, Zhijie Tu, Hong Chen, Shengqi Wang, Guohui Sun, Zhen Rong
Urinary tract infections rank among the most frequent bacterial infections globally, with the majority caused by uropathogenic strains of Escherichia coli (E. coli). Effective management requires timely and reliable diagnostic...
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Screening of aggregation properties of cyclic peptides by protein nanopore

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00427J, Communication

Hang Yang, Wenqi Lu, Dongdong Wang, Xiaoyu Zhang, Minmin Li, Zan Li, Haijuan Qin, Jiaqi Li, Guangyan Qing
Cyclic peptides have been a promising source for natural pharmaceutical macromolecules with their specific binding docks and enhanced binding affinities. However, the aggregation of cyclic peptides poses a significant challenge...
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HCR signal amplification strategy based photothermal sensing for histamine detection

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00601A, Paper

Huiling Xue, Bing Zhang, Ying Zhan, Zhihuan Zhao, Jianying Lin, Yan Cheng
A photothermal aptamer biosensor was built for detecting histamine using HCR amplification and CuS@Au nanocomposites and quantified through the thermometer.
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An advanced GC method for comprehensive residual solvent analysis: overcoming co-elution with orthogonal columns and quantification by mass spectrometry

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D5AY01603G, Paper

Ruba Arulraj, Vinay Vishwanath, Sharad Duche, Arvind Mathur, Amrita Roy
A robust and comprehensive gas chromatographic method was developed to identify and quantify the 57 residual solvents listed in the ICH guidelines, all in a single, 30-minute chromatogram.
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Quantitative determination of maslinic acid and oleanolic acid in olive pomace using high-speed shear extraction and liquid chromatography

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D5AY01925G, Paper

Sheng-Bing Wang, Kun Yang, Dong Pei, Lu-Mei Pu, Xin-Yi Huang
Olive pomace contains abundant maslinic acid and oleanolic acid, which are pentacyclic triterpenoid compounds with excellent biological activity.
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COF hybrid fibrous nano-network aided Surface-enhanced Raman scattering assay for epinephrine analysis

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00679E, Paper

Tianran Yuan, Xueyan Yang, Yinjia Zhao, Longfeng Chu, Liyan Zheng, Xufang Hu, Jing Hu, Qiu-E Cao
Epinephrine is involved in stress response and cardiovascular regulation, and abnormal levels are connected to various neurological and endocrine disorders. Surface-enhanced Raman scattering (SERS) provides rapid and sensitive analysis, but...
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The Development of Aptamer-Functionalized Streptavidin Magnetic Particles for Sample Purification of SARS-CoV-2 Coupled with Rapid Plasmonic RT-qPCR to Improve Detection Sensitivity

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00498A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Joshua Hayes, Alex Resendes, Seung Lee, Mitra Yousefi, Silvia Vidal, Miltiadis Paliouras, Mark Trifiro
Despite having endured numerous pandemics throughout history and contemporary technological advancements, the world was still unprepared for the emergence of the SARS-CoV-2 pathogen.Prior to the development and distribution of effective...
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DNAzyme–aptamer electrochemical biosensor for Pb(II) and Hg(II) determination: robust validation in food matrices and water samples

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00231E, Paper

Chang Su
Dual-mode graphene oxide–gold nanoparticle biosensor detects Pb²⁺ and Hg²⁺ via DNAzyme cleavage (signal decrease) and aptamer folding (signal increase); validated in water, milk, fish, and spinach.
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Construction of a highly sensitive electrochemical sensing platform using an Au–RGO–MWCNTs nanocomposite for the synergistic amplification of rutin detection

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00661B, Paper

Ling-Zhi He, Xiang Li, Zhi-Wen Zeng, Yang Hong, Chi-Qiong Liu, Zhong-Hou Liang, Wen-An Kuang
This work reports the facile construction of an Au–RGO–MWCNTs modified electrode and its application in the electrochemical sensing of rutin.
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Selection and characterization of DNA aptamers specific to trichlorfon

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00588H, Paper

Shuting Yang, Dan Wei, Ziyu He, Li Li, Tong Zhou, Xueying Liu, Yan Deng
Schematic diagram of the capture-SELEX principle and the APTri-7/BP/PLL/AuNPs/GCE sensor manufacturing process.
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A dual mode turn-on probe for H2O2 sensing via fluorescence and colorimetry in live cells and serum

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00388E, Paper

Weitian Chen, Hui Dong, Siyu Wang, Yitong Jiang, Yujia Qian, Aixin Chang, Jiahui Ding, Xue Yang, Yanli Zhou, Yintang Zhang, Zhaohui Li, Maotian Xu
Hydrogen peroxide (H₂O₂), as a crucial intracellular reactive oxygen species (ROS) and secondary messenger, plays a key role in various physiological and pathological processes.
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A novel CRISPR/Cas14a-synergized wood-based platform for ultrasensitive detection of aflatoxin B1

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00717A, Communication

Huixin Chen, Qing Li, Xun Mao
A CRISPR/Cas14a-synergized wood-based platform (CWP) is designed here to detect aflatoxin B1 (AFB1) at 0.67 fmol/L with high sensitivity and no preamplification. Once perform an assay, AFB1 is optical identified...
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Determination of short-chain chlorinated paraffins in carpets by gas chromatography-electron capture negative ionization mass spectrometry

Anal. Methods, 2026, Accepted Manuscript
DOI: 10.1039/D6AY00647G, Paper

Ting Gu, Yongli Wu, Yi Han, Lianrui Mei, Yu Zhang
Short-chain chlorinated paraffins (SCCPs) are commonly employed as flame retardants and plasticizing agents in carpet manufacturing to improve the flame retardancy and durability of carpet products. However, the application of...
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Phosphate-mediated fluorescence switching in a UiO-66-NH2/red carbon dot hybrid for ratiometric and smartphone-assisted visual detection of ethephon

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00422A, Paper

Xiao Hu, Rui Pan, Shufei Huang, Yifan Lin, Meizhu Xu, Caiping Yang, Lishuang Yu, Qiang Zou, Huifeng Xu
A smartphone-integrated ratiometric fluorescent platform was developed for on-site quantitative and visual detection of ethephon (ETH) using a UiO-66-NH₂/red carbon dots (R-CD) hybrid probe.
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Syringe pressure-assisted switchable hydrophilicity solvent microextraction with smartphone digital image colorimetry: a rapid method for trace cobalt determination

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00606J, Paper

Yingying Zhao, Yi Shi, Jiayi Hu, Fuchun Ji, Xin Liu, Huiqiong Huang, Zhengui Li, Shengchun Yang, Xiaodong Wen
This study first integrates syringe pressure-assisted switchable hydrophilicity solvent microextraction with smartphone digital image colorimetry, enabling on-site determination of trace Co²⁺ in water and other samples.
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Waste-derived chlorogenic-acid Ag nanozyme for nanomolar dopamine sensing in pharmaceutical formulations

Anal. Methods, 2026, Advance Article
DOI: 10.1039/D6AY00337K, Paper

Anurag Phukan, Maga Nana Kaka, Moushumi Hazarika, Abhishek Borborah, Manash R. Das, Chandan Tamuly
Biosynthesized nanozymes are attractive for low-cost dopamine sensing, yet most reported systems rely either on synthetic nanomaterials or poorly defined “green” extracts, which limits sustainability, reproducibility, and translational relevance.
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