RSC - Biomater. Sci. latest articles

Stable, Micron-scale Lipocondensates Achieving Prolonged Circulation without PEGlyated Lipids

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00335D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Chia-Wei Yeh , Chelsea Loh , Lianne Jillian Trigiani, Nabeen Chu , Chung-Hao Liu, Mu-Ping Nieh, Nozomi Nishimura, Chris Schaffer, Yadong Wang
Biomolecular condensates are key organizers of cellular biochemistry and are emerging as promising platforms for therapeutic delivery. However, how their molecular composition influences lipid organization and interfacial behavior remains poorly...
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DNA origami as a biomaterials platform for programming ligand–receptor interactions and cell fate

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00524A, Minireview

Xuemei Xu, Yanyan Kong, Zhuoran Mei, Xiang Zhang, Jiajia Zhang
DNA origami has emerged as a versatile biomaterials platform enabling programmable control over the nanoscale spatial organization of ligands.
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Bioorthogonally Reinforced Injectable Granular Hydrogels Synergizing ECM Mimicry with Microporosity for Skin Tissue Engineering

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00379F, Paper

Akshat Joshi, Yasuhiro Ikegami, Yingnan Yue, Yongdeok Jo, Akhilesh Agrawal, Meenakshi Kamaraj, Kawailani Lilly, Jooyoung Park, Diego Noe Rodriguez-Sanchez, Ujjayan Majumdar, Aayush Gupta, Ji-Hoo Lee, Suk-Jung Oh, Shinichi Aishima, Hiroyuki Ijima
Designing injectable biomaterials that simultaneously recapitulate extracellular matrix (ECM) composition while maintaining interconnected microporosity remains a central challenge in regenerative scaffolds. Granular hydrogels offer unique opportunities to address this limitation...
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Multifunctional shape-memory BER@GBP sponges for rapid non-compressible hemostasis and accelerated wound healing

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00360E, Paper

Xiaoya Gao, Rui Tian, Yuqi Cao, Yaxin Wang, Keke Wang, Xinying Liu, Yan Xie
The shape-memory BER@GBP sponge was constructed as a novel biocompatible material for the entire wound treatment process by rapid hemostasis and wound healing.
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Advanced 3D-printed PLA scaffolds functionalized with dual small molecules for enhanced bone regeneration: in vitro and in vivo studies

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00733C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nisa İrem Büyük, Ezgi Hacıhasanoğlu, Çağla Çiçek, Gamze Torun Köse
A dual small molecule-functionalized 3D-printed PLA scaffold integrates osteogenic and endothelial cues to enhance vascularized bone regeneration in a critical-sized calvarial defect model.
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Host-Directed Antimicrobial Peptide Biomaterials for Combating Gram-Negative Bacterial Infections

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00666C, Review Article

Muhammad Adil, Muhammad Arshad, Pengfei Zou, Li-Li Li
Antimicrobial resistance (AMR) represents a defining crisis in modern infectious disease medicine. Gram-negative microbes such as carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae are becoming more resistant than ever....
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Fabrication of pH-responsive self-assembled biofilaments and their application in non-invasive monitoring of wound healing

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00329J, Paper

Lelona Pradhan, Niyamat M. A. Chimthanawala, Santosh Biranje, Sandeep More, Sadhana S. Sathaye, Ravindra V. Adivarekar
Pyranine-loaded biopolymer filaments via polyelectrolyte complexation for pH-responsive fluorescence. The prototype validates non-invasive, real-time wound monitoring in normal and diabetic rodent models, offering a low-cost, patient-centric device.
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Correction: Bioinspired synergistic chitosan–graphene–tannin hydrogel orchestrates inflammation resolution and accelerates skin tissue repair

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM90044E, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Isleidy Ruíz, Luisbel González, Julia Eduarda Schneider Gregório, Cintia Sena Bueno, Maria Esméria Corezola do Amaral, Guilherme Ferreira Caetano, Katherina Fernández
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Electrospun aligned nanofibers for tissue engineering

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01732G, Review Article

Gayatri Patel, Nasim Annabi, Louis Bouchard
Tissue engineering aims to repair and regenerate damaged tissues using scaffolds that mimic the natural extracellular matrix (ECM). Aligned nanofibrous scaffolds have gained prominence due to their ability to replicate...
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An integrated lubricating and antibacterial hydrogel coating for the inner surface of medical catheters

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00573J, Paper

Guofa Zhang, Qianqian Sun, Bing Li, Bo Wu, Wei Ding, Litao Wang, Mei Lv
Hydrogel-iodine coating reaches 96.1% bactericidal efficiency, supports >80% viability of MC3T3-E1 cells, and shows a 33.7° water contact angle, presenting outstanding lubrication, antibacterial and hydrophilic performances.
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Rapid preparation of bioadhesive with wet adhesion based on supramolecular interactions for wounds closure and healing

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00578K, Paper

Shijie Zhang, Shanzeng Dong, Lingjun Geng, Huihu He, Jiujiang Zeng, Kongwang Hu
Achieving wet adhesion is a fundamental yet challenging requirement for bioadhesives.The poly(α-lipoic acid) (PLA) adhesive derived from the polymerization of α-lipoic acid (LA) has attracted increasing attention in the biomedical...
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A multifunctional chemotactic-antibacterial ChMA–AgNPs hydrogel for the treatment of carbapenem-resistant Pseudomonas aeruginosa-infected wounds

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00417B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xinxin Su, Morui Gui, Tingna Luo, Qiqi Liu, Xiaohong Zhao, Yicheng Guo, Rixing Zhan, Zhongshuo Hao, Xisheng Xu, Shuncai Liu, Zhenyu Gong
L-lysine-modified chitosan hydrogel loaded with AgNPs targets CRPA-infected wounds. Relying on L-lysine-triggered chemotaxis, it exerts antibacterial, anti-inflammatory and pro-angiogenic functions to accelerate wound repair.
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A NIR assisted composite scaffold incorporating CuHP and melatonin for enhanced anti-infection and bone regeneration in an acute rat model of infected bone defect

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00251J, Paper

Long Zhou, Shuangjian He, Jian Gu, Yunfei Liu, Peng Zhang
A NIR-assisted PGCuM scaffold integrating CuHP and MT was fabricated. In infected rat bone defects, PGCuM + NIR achieved superior bacterial clearance and new bone formation. MT presence correlated with inflammation resolution and M2 polarization.
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Orchestrating bone healing: biomaterial-driven immunoengineering of the bone microenvironment for advanced regenerative therapies

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00388E, Review Article

Ah Joung Rachel Yu, Mohammad Reza Zare, Edikan Ogunnaike, Mostafa Yazdi
Harnessing osteoimmunology, programmable biomaterials direct immune responses to coordinate inflammation, angiogenesis, and osteogenesis for improved bone regeneration.
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An injectable multifunctional extracellular matrix-based hydrogel with antibacterial and pro-regenerative functions for infected wound healing

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00484A, Paper

Zhiqiang Zhu, Xiaojiao Guo, Shilu Zhu, Tianao Chen, Liping Zhao, Zhongliang Lang
Integrating a silver nanoparticle-loaded ECM hydrogel with growth factor-releasing alginate microspheres to sequentially combat infection and promote regeneration for accelerated infected wound healing.
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Mechanical stress-driven conformational compaction of polydeoxyribonucleotide for enhanced transdermal regenerative therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00713A, Paper

Saetbyeol Jeon, Jung Im Lee, Sung Bo Shim, Chul Hwan Kim, Taek Jin Oh, Marta Gonçalves, Jin Woong Kim
Chemically unmodified PDRN undergoes mechanical stress-driven conformational compaction, enhancing transdermal penetration, cellular uptake, and regenerative efficacy while preserving native receptor-mediated bioactivity.
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Tunable bio-inspired hybrid hydrogels reprogram stem cell-derived extracellular vesicles for superior wound regeneration

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00097E, Paper

Yen-Han Lai, Suhana ., Su-Shin Lee, Ke-Hsun Yang, Yi-Chia Wu, Pavanchandh Atturu, Chung-Yuan Chan, Chih-Kuang Wang
Clinical translation of adipose-derived stem cell (ADSC)-derived extracellular vesicles (EVs) for cutaneous regeneration is challenged by variable secretion levels, heterogeneous molecular cargo, and inconsistent therapeutic potency. Here, we developed a...
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Fibrotic-like collagen matrices as 3D in vitro models for investigating the impact of pathological extracellular matrix on skeletal muscle cell behavior

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00046K, Paper

Marie Camman, Naomi Nieswic, Maxime Mauviel, Pierre Joanne, Julie Brun, Lena Villerabel, Alba Marcellan, Onnik Agbulut, Christophe Helary
Collagen matrices that recapitulate the structural and mechanical features of skeletal muscle fibrosis can be fabricated using 3D printing. These fibrotic matrices impair the differentiation of C2C12 myoblasts into myotubes.
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An esterase-activated celastrol delivery system suppressed steatosis-related hepatocellular carcinoma progression

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00447D, Paper

Zile Shao, Yangla Xie, Yidan Shen, Yiyang Sun, Long Zhang, Nasha Qiu, Xiao Xu
Schematic illustration of intratumorally delivered PQDMA@CEL NPs, triggering HCC ferroptosis and degrading lipids, and further remodeling immunosuppressive microenvironment and enhancing anti-tumor efficacy in Hepa1-6 bilateral tumor models.
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Bioprinting chondrocyte hydrogel cultures onto fibre membranes for cartilage defect repair

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00467A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Fatma Ozdemir Steedman, Ana Marina Ferreira, Priscila Melo, Kenneth Dalgarno
Bioprinting of cell filled hydrogels onto Chondro-Gide® substrates offers a promising strategy for next-generation MACI, enhancing cell viability, proliferation, ECM production, and mechanical performance.
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Towards supramolecular regenerative medicine using low-molecular-weight gelator hydrogels for stem cell growth

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00661B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Chayanan Tangsombun, David K. Smith
This review explores gels that assemble from low-molecular-weight gelator (LMWG) building blocks for use in cell culture, with a focus on fibroblasts and stem cells, highlighting the unique capabilities of these tunable and dynamic materials.
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Biomimetic MXene nanoplatform for tumor-specific synergistic phototherapy and immune reprogramming in pancreatic cancer

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00210B, Paper

Tong Yin, Xiaodong Zhu, Yue Wu, Jingyu Liu, Yulin Xing, Xiaoxiao Wu, Xian Liu, Huawei Xu, Dan Feng, Jie Li, Xiaobo Peng, Wei Li, Xianbao Zhan
A biomimetic MXene nanoplatform enables tumor-targeted, oxygen self sufficient PTT/PDT, triggering ICD and T cell immunity. Combined with αPD-1, it suppresses both primary and distant pancreatic tumors, overcoming immunotherapy resistance.
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Degradable multi-arm PEG hydrogels with tunable stiffness and diffusivity

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00440G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Kristie Cheng, Evelyn Lim, Brett Stern, Janet Zoldan, Nicholas Peppas
Modular PEGNB hydrogels recapitulate mechanically relevant bone marrow microenvironments for 3D stem cell culture.
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Dynamic hydrogels for bone tissue engineering: modulating the fate of resident MSCs

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00444J, Review Article

Yan Chen, Chenyu Rao, Zhengyi Xu, Yi Man, Yili Qu, Chen Hu
Dynamic hydrogels modulate resident MSC behaviors, offering a promising therapeutic strategy for bone tissue engineering (BTE).
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Light-programmable, high-drug-loading nanomedicine based on dimeric camptothecin

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00328A, Paper

Lei Wu, Yehan Wang, Kaimin Cai, Yang Zhou, Yong Wang, Jianjun Cheng, Hua He, Lichen Yin
Light-programmable, high-drug-loading PEG-PLA nanoparticles were developed to co-encapsulate both the photosensitizer (Ce6) and the hypoxia-activatable dimeric camptothecin prodrug (hQ-CPT₂) for synergistic antitumor treatment.
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Applications of carbon-based materials in photothermal therapy for drug-resistant tumors: a review of research from synergistic therapy to theranostics

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00385K, Review Article

Fangyuan Shi, Jintao Deng, Fengzhu Yang, Wenhao Fu, Xibo Guan, Wenlong Sun, Xinhua Song, Meng Wang
Multidrug resistance severely limits the therapeutic efficacy of cancer treatment, and carbon-based material-mediated photothermal therapy provides a promising strategy for overcoming tumor drug resistance.
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Bridging mechanobiology and engineering: recent advances in nano-based materials and devices for therapeutics and tissue regeneration

Biomater. Sci., 2026, 14,3082-3110
DOI: 10.1039/D5BM01552A, Review Article

Soumyadeep Basak, Gopinath Packirisamy
This review highlights how “active” nanomaterials and mechanical stimulation devices control cell fate via mechanotransduction. It explores cellular mechanoresponses to advance therapeutics and regenerative medicine.
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Inhalable viromimetic polymer nanoparticle vaccine (iVPNVax) in a subcutaneous-prime/inhalation-boost vaccination schedule for eliciting durable mucosal and systemic immune protection

Biomater. Sci., 2026, 14,3313-3325
DOI: 10.1039/D6BM00350H, Paper

Zhenyi Zhu, Xinyu Zhuang, Zichao Huang, Chenchao Zhang, Tong Zhang, Liping Liu, Aolin Sun, Jiangai Long, Yusong Cao, Yaxin Zhang, Ying Xing, Songhui Yang, Jianan Peng, Siyou Huang, Ningning Hu, Mingyao Tian, Wantong Song, Xuesi Chen
An inhalable viromimetic nanoparticle vaccine resolves the size mismatch between aerosol deposition and immune activation, enabling effective lung delivery, sustained antigen retention, and coordinated mucosal and systemic immunity.
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Hydrogel–exosome synergistic system: mechanisms, applications and future prospects in regenerative medicine

Biomater. Sci., 2026, 14,3049-3081
DOI: 10.1039/D6BM00274A, Review Article

Bin Xie, Yuyi Kang, Shuihao Zhao, Zhiyun Wu, Zelin Wu, Xiubin Kuang, Jiahong Jiang, Nuo Xu, Xudong Lin, Jun Wu, Tak-Man Wong, Shaoquan Bian, Xiaoli Zhao, Zhengqiang Yuan
This review delves into the promising hydrogel–exosome synergistic system in regenerative medicine, focusing on its fabrication, smart regulation, and synergistic interaction mechanisms underlying enhanced angiogenesis, tissue repair and regeneration.
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A Janus-structured PVA/collagen membrane co-loaded with Orthosiphon aristatus extract and DMOG for diabetic wound healing

Biomater. Sci., 2026, 14,3326-3343
DOI: 10.1039/D6BM00266H, Paper

Fan-Ting Meng, Xue Xu, Lin Zhu, Yi Xie, Hai-Yan Wang, Yu-Qing Zhang
A Janus-structured PVA/collagen membrane co-loaded with Orthosiphon aristatus extract and DMOG accelerates diabetic wound healing through antioxidant, antimicrobial, and pro-angiogenic effects.
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Bioinspired synergistic chitosan–graphene–tannin hydrogel orchestrates inflammation resolution and accelerates skin tissue repair

Biomater. Sci., 2026, 14,3235-3251
DOI: 10.1039/D5BM01612F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Isleidy Ruíz, Luisbel González, Julia Eduarda Schneider Gregória, Cintia Sena Bueno, Maria Esméria Corezola do Amaral, Guilherme Ferreira Caetano, Katherina Fernández
Wound healing remains a major clinical challenge due to the complex metabolic disturbances present within the wound microenvironment.
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Genetically engineered Spirulina plantensis producing human insulin as a potential novel oral drug delivery carrier

Biomater. Sci., 2026, 14,3200-3215
DOI: 10.1039/D5BM00817D, Paper

Dhaval Patel, Eliyahu Drori, Valeria Rahamim, Aman Thakur, Adi Dahan, Sivan Meir, Yamm Anker, Palak Sangrai, Yaakov Anker, Aharon Azagury
Engineered Spirulina as a living, edible bioreactor and carrier: stable expression of bioactive human insulin, scalable production, and enhanced intestinal uptake—advancing a bioadhesive, noninvasive paradigm for oral protein delivery.
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Silica-coated papillomavirus-based nanoparticles: a shielded scaffold for HIV-1 vaccines

Biomater. Sci., 2026, 14,3281-3294
DOI: 10.1039/D5BM01792K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yu Wang, Kathrin Kostka-Wirtz, Nils Bartelsen, Kateryna Loza, Christoph Weingärtner, Philipp Arnold, Dominik Damm, Klaus Überla, Matthias Epple, Vladimir Temchura
Silica-coated HPV L1 VLPs shield scaffold-directed immunity while enabling multivalent display of HIV-1 Env trimers and promoting antigen-specific B cell responses.
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Beyond first responders: neutrophils shape biomaterial-guided regeneration

Biomater. Sci., 2026, 14,3157-3180
DOI: 10.1039/D6BM00277C, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Márcia Monteiro Pereira, Ana Beatriz Sousa, Judite Novais Barbosa
Neutrophils actively shape biomaterial-guided regeneration by orchestrating angiogenesis, inflammation resolution, and tissue repair through their remarkable functional plasticity.
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Folic acid-targeted PLGA nanoparticles co-delivering doxorubicin and MnTPP enable ultrasound-triggered synergy and apoptosis in nasopharyngeal carcinoma

Biomater. Sci., 2026, 14,3252-3265
DOI: 10.1039/D5BM01648G, Paper

Min Zhang, Chunmiao Chen, Dandan Sun, Dayan Yang, Lingling Qin, Yanhua Cui, Xiangxiang Jing
Folic acid-targeted PLGA nanoparticles co-delivering Dox and MnTPP enable ultrasound-triggered sonodynamic–chemotherapy synergy, inducing ROS generation, DNA damage, and enhanced apoptosis in nasopharyngeal carcinoma.
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Functional peptide-assisted delivery of CRISPR/Cas9: recent progress on gene editing

Biomater. Sci., 2026, 14,3132-3156
DOI: 10.1039/D6BM00231E, Review Article

Hye Min Cho, Yeong Chae Ryu, Min Kyu Cho, Byeong Hee Hwang
The CRISPR/Cas9 system has transformed the field of genome engineering by enabling precise and programmable modification of genomic sequences.
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A mechanistic study on the SIRT3/RORγt/STAT3-regulated Th17-targeted bionic black phosphorus quantum dot cluster nanozyme for improving sepsis-associated acute kidney injury

Biomater. Sci., 2026, 14,3216-3234
DOI: 10.1039/D5BM01669J, Paper

Qinbiao Chen, Yanli Ma, Yuewu Tang, Ni Du
Sepsis-related acute kidney injury (SA-AKI) represents a severe complication associated with elevated mortality rates, primarily driven by imbalanced Th17 immune responses and mitochondrial dysfunction.
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A regenerative cerium oxide nanozyme for cataract treatment via oxidative stress regulation

Biomater. Sci., 2026, 14,3295-3312
DOI: 10.1039/D6BM00331A, Paper

Hongying Xie, Yajia Wang, Jiahao Wang, Zhenbiao Xu, Chunyi Weng, Quankui Lin
SOD and CAT activities mimicked cerium oxide nanozymes with effective intracellular ROS scavenging property were developed as a non-surgical antioxidant therapy for cataract via lens cells protection.
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A GMP-compliant formulation of regeneratively active polyphosphate for wound healing and skin regeneration

Biomater. Sci., 2026, 14,3181-3199
DOI: 10.1039/D6BM00151C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Werner E. G. Müller, Meik Neufurth, Xiaoqin La, Hadrian Nassabi, Mathias Brösicke, Rita Dobmeyer, Rafael Muñoz-Espí, Changxin Wu, Hiroshi Ushijima, Heinz C. Schröder, Xiaohong Wang
A GMP-compliant amorphous polyphosphate formulation acts as an energy-delivering biomaterial that promotes ATP-dependent skin regeneration, accelerating chronic wound healing and enhancing hair growth in human, veterinary and preclinical models.
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Retina-targeted siRNA delivery via exosome–liposome hybrid vesicles for AMD treatment

Biomater. Sci., 2026, 14,3266-3280
DOI: 10.1039/D6BM00090H, Paper

Yangyang Huang, Xingyu Zhu, Ruiyang Lu, Kai Jiang, Lijuan Zhu, Xujiao Zhou, Jiaxu Hong, Chuan Zhang
A novel exosome–liposome hybrid vesicle is engineered for retina-targeted siRNA delivery. This platform can effectively silence the target gene, offering a promising RNAi-based strategy for treating retinal disorders.
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Recent advances in hemoperfusion adsorbents: from material innovations to emerging application systems

Biomater. Sci., 2026, 14,3111-3131
DOI: 10.1039/D6BM00131A, Review Article

Xinjie Liu, Fanling Meng, Liang Luo
Hemoperfusion has unique therapeutic advantages in clinic. This review summarizes technological innovations in both traditional (activated carbon, polymers, etc.) and novel adsorbent materials (carbon, 2D materials, and ordered porous materials).
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Modeling Hypoxia Integrated Glioblastoma Microenvironment to Mimic Tumor Heterogeneity and Chemoresistance

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01824B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

ŞEYMA IŞIK, Deniz Yucel, Vasif Hasirci
Glioblastoma (GBM) is a highly aggressive brain tumor in which hypoxia plays a central role in driving tumor progression, cellular plasticity, and resistance to treatment. In order to mimic these...
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Choline-based hydrogels and deep eutectic solvent systems for next-generation biomedical platforms: a review

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00517A, Review Article

Anshu Sharma, Bong-Seop Lee
Quaternary ammonium containing hydrogels have been widely investigated for antimicrobial and drug delivery applications, yet concerns related to cytotoxicity, limited biodegradability, and environmental persistence remain unresolved.
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Tumor-confined delivery via syringeable hydrogels for reinforced immunomodulatory intervention

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00275G, Review Article

Shuying Ji, Xingxing Liu, Tingting Liu, Yangming Zhang, Mengjiao Zhou, Yumin Yang, Haijun Yu, Weiqi Wang
Syringeable hydrogels have emerged as transformative tools for precise drug delivery and controlled release, capitalizing on their exceptional injectability, shape adaptability, and localized retention.
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A spatiotemporally controllable magnetic microneedle for targeted gastric drug delivery

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00271D, Paper

Jun Luo, Shuyue Deng, Shibo Zhang, Yanbing Zhao, Xinyi Xu, Ran An, Jianjun Dai, Yanmin Ju
A gastric-targeted oral microneedle is magnetically controlled to penetrate the gastric mucosa and release drugs in a pH-responsive manner. It carries diverse payloads from small molecules to biomacromolecules and shows in vivo efficacy.
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A structurally reassembled sunflower stem pith composite sponge for prehospital temporary emergency hemostasis

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00506C, Paper

Yan Shi, Peng Zhao, Mengyang Mao, Siyi Tong, Jinrui Li, Jiaxuan Zhao, Hu Hou, Ming Kong
An isotropic SSP–chitosan sponge with shape memory for rapid prehospital hemostasis was prepared.
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Fucoidan-coated metal–organic framework nanoparticles for targeted delivery of nimodipine in subarachnoid hemorrhage-induced vasospasm

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00552G, Paper

Chang Hee Min, Sung Ho Lee, Dong Su Kang, Se-Na Kim, Ye Young Kim, Dabin Lee, Hyunseo Choi, Yi Rang Na, Won-Sang Cho, Young Bin Choy
Fucoidan-coated metal–organic framework nanoparticles enable clot anchoring and sustained drug release for the treatment of subarachnoid hemorrhage-induced vasospasm.
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Dual-targeting macrophage membrane nanosystem enhances radiotherapy-induced antitumor immunity via synergistic nuclear and mitochondrial DNA damage

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00279J, Paper

Guangyu Ju, Qi Ding, Hongcang Gu, Rao Liu, Xiao Liu, Zimeng Wang, Kaiwei Wang, Yuan Ping, Jian You, Shuanghu Yuan, Junchao Qian
A macrophage membrane-coated gold nanosystem enables inflammation-guided tumor targeting and enhances radiotherapy by promoting mitochondrial RNA release and sustained DNA damage, thereby amplifying antitumor immune responses.
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Graphene oxide-chitosan nanocomposites for phenethyl isothiocyanate delivery in glioma

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00008H, Paper

Jayaseema Dasan Mary, Yu-Wen Chen, Christu Rajan Yesudoss, Ming-Huang Lin, Chia-Huei Lin, Selvanayagam Mariadoss, Hsien-Ming Lee, Dennis W. Hwang
Graphene oxide–chitosan nanocomposites provide a biocompatible platform for sustained PEITC delivery, enhancing tumor retention and tumor growth suppression in a subcutaneous C6 glioma model.
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Design and validation of a bioactive and antimicrobial coating through advanced deposition strategies for biomedical applications

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00291A, Paper

Giusy Sorvillo, Rosa Calderon-Jacinto, Yijie Li, Léa Magne, Cynthia Calligaro, Rémy Agniel, Grégory Francius, Nicolas Courtois, Philippe Lavalle, Damien Seyer, Nihal Engin Vrana, Emmanuel Pauthe, Adeline Gand
Bifunctional PLL₃₀/HA/Fn polyelectrolyte multilayer coatings engineered by Layer-by-Layer assembly to confer simultaneous antibacterial activity and cytocompatibility are translated to spray-assisted deposition for peri-implantitis management.
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Micro- and nanoscale CaCO3 carriers for localized melanoma therapy: impact of ‘cold’ labeling on drug loading, release, and in vivo performance

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00418K, Paper

Darya R. Akhmetova, Vladislava A. Rusakova, Denis A. Matveev, Darya P. Toloknyannikova, Jiaxian Cai, Bochang Feng, Menghua Xiong, Sergei A. Shipilovskikh, Dong Luo, Alexander S. Timin
Calcium carbonate micro- and nanoparticles are engineered as multifunctional carriers for eefective drug loading and radionuclide-compatible ‘cold’ labeling.
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Correction: An ROS-sensitive tegafur-PpIX-heterodimer-loaded in situ injectable thermosensitive hydrogel for photodynamic therapy combined with chemotherapy to enhance the tegafur-based treatment of breast cancer

Biomater. Sci., 2026, 14,3038-3038
DOI: 10.1039/D5BM90099A, Correction

Open Access

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Zhiqiang Zhang, Anning Li, Xingqi Min, Qunqun Zhang, Jun Yang, Guo Chen, Meijuan Zou, Wei Sun, Gang Cheng
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Inflammation-responsive hierarchical delivery of anti-inflammatory siRNA and peptide alleviates cytokine storm in pneumonia

Biomater. Sci., 2026, 14,3013-3023
DOI: 10.1039/D5BM01911G, Paper

Xiaohui Li, Shanzhou Duan, Jiandong Yang, Chunxian Piao, Yang Zhou, Chenglong Ge, Qiujun Liang, Minhyung Lee, Lichen Yin, Yongbing Chen
Inflammation-responsive nanocomplexes (NCs) capable of penetrating both the mucus and cytomembrane barriers were developed for acute lung injury treatment through siRNA-mediated TNF-α silencing and RBP-mediated RAGE blocking.
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Tuning hydrogel properties and Schwann cell behavior through microchannel size control in magnetically templated hydrogels

Biomater. Sci., 2026, 14,2995-3012
DOI: 10.1039/D5BM01573A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Victor G. Rivera-Llabres, Zoe A. Fields, Hayden J. Good, Elizabeth L. Aikman, Stephanie Manrique, Adeline Schmidt, Eleana Manousiouthakis, Whitney L. Stoppel, Christine E. Schmidt, Carlos M. Rinaldi-Ramos
Peripheral nerve injury is a common condition and the development of materials that enhance Schwann cell migration to aid in regeneration is critical as the body has a limited ability to repair transected nerves.
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Brush-like copolymer and MXene-functionalized PVA/PEEK scaffolds: enhancing lubrication in metatarsophalangeal joint prostheses

Biomater. Sci., 2026, 14,2956-2969
DOI: 10.1039/D5BM01375E, Paper

Jian Pu, Nengshen Zhang, Luyao Tang, Zemin Ling, Chao Zhang, Jian Song
Inspired by mechanisms in nature, a PVA-based composite that achieves ultra-low friction (COF = 0.033) for MTP implants has been developed by combining brush-like copolymer lubrication with shear-released MXene nanosheets.
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Functionalized collagen-based sponge dressing integrating negative pressure wound therapy and photothermal antibacterial treatment for advanced wound management

Biomater. Sci., 2026, 14,2943-2955
DOI: 10.1039/D6BM00297H, Paper

Jiaqi Zhou, Jingjing Yu, Tianshuo Hu, Jingyi Li, Cuicui Ding, Lihui Chen, Hui Wu, Min Zhang
A GO/PVA/COL composite sponge fabricated via low-temperature foaming integrates wet-state mechanical robustness, photothermal antibacterial activity, and NPWT compatibility to significantly accelerate infected wound healing.
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Biofabrication of 3D-printed fibrous scaffolds for large muscle tissue engineering: enhancing scalability, myotube formation and surgical handling

Biomater. Sci., 2026, 14,2894-2910
DOI: 10.1039/D5BM01465D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Eva Schätzlein, Oliver Weeger, Sebastian Scholpp, Leon Faulhaber, Anna Fritschen, Jamina Sofie Gerhardus, Robin Maatz, Annabelle Neuhäusler, Souraj Mandal, Regine von Klitzing, Andreas Blaeser
A multimodal 3D-bioprinting process for fabrication of muscle precursors with high suture retention strength and biofunctionality.
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Hybrid cell membrane-conjugated photosensitive hydrogels as a tumor vaccine for promoting cancer immunotherapy

Biomater. Sci., 2026, 14,2983-2994
DOI: 10.1039/D6BM00261G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chaoying Wang, Tao Wang, Wenxin Zhou, Yanxu Li, Weiben Ji, Shengyi Wu, Yutao Feng, Lai Chang, Quan Zhang, Wei Wu
Mechanism of preventive tumor vaccines based on hydrogel system.
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Thermoresponsive hydrogels for controlled drug delivery to the back of the eye: a data-driven guide to formulation design

Biomater. Sci., 2026, 14,2824-2846
DOI: 10.1039/D6BM00104A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alexa K. Beathard-Wojan, Vibhuti Agrahari
This study comprehensively evaluates intravitreal thermoresponsive, drug-loaded hydrogels, highlighting how polymer composition and therapeutic class influence mechanical properties, safety, and release to guide rational formulation design.
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Simvastatin attenuates endothelial dysfunction in a coronary artery-on-a-chip

Biomater. Sci., 2026, 14,2880-2893
DOI: 10.1039/D6BM00327C, Paper

Jasneil Singh, Deepu Ashok, Henry Howard, Steven G. Wise, Anna Waterhouse
A coronary artery-on-a-chip mimics shear-dependent endothelial dysfunction and immune cell adhesion at bifurcations, which are reversed following simvastatin treatment (scale = 100 µm).
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Correction: Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway

Biomater. Sci., 2026, 14,3036-3037
DOI: 10.1039/D6BM90034H, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Nianqiang Jin, Nuo Jin, Zilin Wang, Lili Liu, Lin Meng, Daowei Li, Xing Li, Dabo Zhou, Jie Liu, Wenhuan Bu, Hongchen Sun, Bai Yang
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Slippery lubricant-infused surfaces with anti-fouling and antimicrobial properties for preventing biofouling in biomedical applications

Biomater. Sci., 2026, 14,2847-2860
DOI: 10.1039/D6BM00212A, Minireview

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Grace H. Nguyen, Elizabeth J. Brisbois
This review evaluates slippery lubricant-infused surfaces (SLIPS) as anti-fouling and antimicrobial coatings, contrasting traditional, smart, and bioactive designs for preventing infection, thrombosis, and device failure.
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Microparticle uptake reduces efferocytic capacity of macrophages

Biomater. Sci., 2026, 14,3024-3035
DOI: 10.1039/D5BM01447F, Paper

Shivangi Mishra, Bharti Aggarwal, Prem Singh Anant, Avinash Bajaj, Siddharth Jhunjhunwala
Uptake of large (~3 µm) sized particles affects efferocytosis capacity of macrophages.
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Plasmonic fluorescent Ag/C-based nanohybrids for treatment of chemically-induced cutaneous burns

Biomater. Sci., 2026, 14,2970-2982
DOI: 10.1039/D5BM01540E, Paper

Halyna Kuznietsova, Iryna Byelinska, Arsen Ishchuk, Vladimir Lysenko, Alexander Zaderko, Yury V. Ryabchikov, Olga Pylypova, Kostiantyn Paliienko, Nataliia Dziubenko
Silver nanoparticle/carbon dot nanohybrids (Ag/C NHs) aid healing in rat burn models: Ag/C197 enhances early repair in acidic burns, while Ag/C195 improves later-stage healing, reduces inflammation, and supports regeneration.
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Photothermal self-adjuvant porous microneedles for self-healing encapsulation and sustained release of antigens to improve adaptive immunity

Biomater. Sci., 2026, 14,2861-2879
DOI: 10.1039/D5BM01847A, Paper

Xin Wang, Zhiming Li, Jiahui Fu, Xueyu Wen, Zhenni Chen, Shaohua Li, Tianqi Liu, Fei Jia, Hao Chang
Photothermal porous microneedles enable rapid self-healing antigen encapsulation and sustained intradermal release. Local NIR-triggered hyperthermia acts as a physical adjuvant, eliciting potent and durable antigen-specific immunity and memory.
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Engineering immunostimulatory nanocarriers: TLR7-agonist conjugated poly(beta-amino ester) mRNA delivery systems

Biomater. Sci., 2026, 14,2928-2942
DOI: 10.1039/D5BM01812A, Paper

Open Access

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Hulya Bayraktutan, Amr ElSherbeny, Rafał J. Kopiasz, Charlotte Galley, Nurcan Gumus, Clare L. Bennett, Cameron Alexander, Pratik Gurnani
Adjuvanted mRNA polyplex enhances their immunostimulatory effect.
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Zinc-chelated cuttlefish ink melanin nanoparticle-complexed sprayable chitosan-based hydrogel for promoting infected wound healing

Biomater. Sci., 2026, 14,2911-2927
DOI: 10.1039/D6BM00302H, Paper

Ruimin Zhan, Lu Liu, Yan Shi, Jinrui Li, Dandan Jing, Mengyang Mao, Qian Yu, Siyi Tong, Hu Hou, Hui-Min David Wang, Zhiguo Wang, Ming Kong
The HGM@Zn²⁺ sprayable hydrogel dressing markedly accelerates the healing process of infected wounds by synchronizing photothermal antibacterial activity, antioxidative capacity, and proangiogenic properties.
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Engineering immune-evasive islet replacement: cell-intrinsic and peri-graft strategies

Biomater. Sci., 2026, 14,2805-2823
DOI: 10.1039/D6BM00014B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Myungji Kim, Minji Kim, Jinah Jang
This review introduces recent progress in immune-evasive islet replacement by integrating advances in cell-intrinsic immune engineering with bioengineering strategies that regulate the peri-graft physicochemical milieu.
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