RSC - Biomater. Sci. latest articles

Mussel-inspired bioactive ceramics with improved bioactivity, cell proliferation, differentiation and bone-related gene expression of MC3T3 cells

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60028A, Paper

Mengchi Xu, Yufeng Zhang, Dong Zhai, Jiang Chang, Chengtie Wu
Polydopamine-modified akermanite bioceramics with improved bioactivity.
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Iron oxide nanoparticle-based radio-frequency thermotherapy for human breast adenocarcinoma cancer cells

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60015G, Paper

Thikra Mustafa, Yongbin Zhang, Fumiya Watanabe, Alokita Karmakar, Madhu P. Asar, Reginald Little, M. Keith Hudson, Yang Xu, Alexandru S. Biris
We demonstrate that it is possible to control the apoptosis of human breast cancer cells (MCF-7) by tuning the size of iron oxide nanoparticles to fit a particular RF frequency.
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Mesenchymal stem cell response to TGF-[small beta]1 in both 2D and 3D environments

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60057B, Paper

Ryan S. Stowers, Charles T. Drinnan, Eunna Chung, Laura J. Suggs
Simultaneous presentation of fibrin-based matrices and TGF-[small beta]1 promotes expression of smooth muscle markers while maintaining upregulated vascular markers and morphology.
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Cell phenotypic changes of mouse connective tissue fibroblasts (L-929) to poly(ethylene glycol)-based gels

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60055F, Paper

Christine Strehmel, Zhenfang Zhang, Nadine Strehmel, Marga C. Lensen
Distinct intra- and extracellular changes in primary metabolism of fibroblasts cultured on novel PEG-based gels were identified by GC-MS.
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Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM00178D, Paper

Haruko Takahashi, Yoshiro Tahara, Shin-ichi Sawada, Kazunari Akiyoshi
Cationic amphiphilic polysaccharide nanoballs showed promising potential as an effective protein delivery nanocarrier.
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Surface-modified magnetic human cells for scaffold-free tissue engineering

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60054H, Communication

Maria R. Dzamukova, Ekaterina A. Naumenko, Natalya I. Lannik, Rawil F. Fakhrullin
In this communication we report for the first time the magnetically-facilitated scaffold-free assembly of lung tissue mimicking two-layered multicellular clusters. Polymer-stabilized magnetic nanoparticles were deposited on surfaces of viable A549 and skin fibroblast cells, allowing the formation of two-layered porous tissue prototypes.
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Biomaterials in RNAi therapeutics: quo vadis?

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60071H, Minireview

Ernst Wagner
Alternative directions in RNAi delivery include either minimization into small drug-like chemical entities or wrapping up into larger virus-like nanoparticles.
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Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct

Biomater. Sci., 2013, 1,581-588
DOI: 10.1039/C3BM00191A, Communication

Karin L. Lee, Logan C. Hubbard, Stephen Hern, Ibrahim Yildiz, Miklos Gratzl, Nicole F. Steinmetz
Nanomaterial-based carrier systems hold great promise to deliver therapies with increased efficacy and reduced side effects.
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N-Acetyl-L-cysteine capped quantum dots offer neuronal cell protection by inhibiting beta (1-40) amyloid fibrillation

Biomater. Sci., 2013, 1,577-580
DOI: 10.1039/C3BM60029G, Communication

Olivia T. W. Ng, Yi Wong, Ho-Man Chan, Jing Cheng, Xiao Qi, Wing-Hong Chan, Ken K. L. Yung, Hung-Wing Li
This is the first work that revealed the neuro-protective effect of functionalized quantum dots against the cytotoxicity induced by beta-amyloid peptides.
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Biomaterial approaches to gene therapies for neurodegenerative disorders of the CNS

Biomater. Sci., 2013, 1,556-576
DOI: 10.1039/C3BM60030K, Review Article

Ben Newland, Eilis Dowd, Abhay Pandit
This review highlights the progress of the use of biomaterials to aid gene therapies for applications in neurodegenerative disorder therapies.
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Sugar/gadolinium-loaded gold nanoparticles for labelling and imaging cells by magnetic resonance imaging

Biomater. Sci., 2013, 1,658-668
DOI: 10.1039/C3BM60032G, Paper

Ainhoa Irure, Marco Marradi, Blanca Arnaiz, Nuria Genicio, Daniel Padro, Soledad Penades
Gold nanoparticles coated with sugars and Gd-complexes are efficient magnetic resonance imaging (MRI) probes for selective cell labelling.
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Silica as a morphogenetically active inorganic polymer

Biomater. Sci., 2013, 1,669-678
DOI: 10.1039/C3BM00001J, Paper

Werner E. G. Muller, Xiaohong Wang, Vlad Grebenjuk, Barbel Diehl-Seifert, Renate Steffen, Ute Schlo[German sz ligature}macher, Anna Trautwein, Sebastian Neumann, Heinz C. Schroder
Gene expression studies suggest that silica causes morphogenetic processes in bone-related SaOS-2 cells via BMP-2 rather than the BMP-2-independent RUNX2 pathway.
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Facile preparation of multifunctional hollow silica nanoparticles and their cancer specific targeting effect

Biomater. Sci., 2013, 1,647-657
DOI: 10.1039/C3BM00007A, Paper

Banalata Sahoo, K. Sanjana P. Devi, Sumanta Kumar Sahu, Suryakanta Nayak, Tapas K. Maiti, Dibakar Dhara, Panchanan Pramanik
A unique and simple method was established for fabrication of multifunctional silica nanoparticles with superior cancer-specific targeting and imaging properties.
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Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy

Biomater. Sci., 2013, 1,633-646
DOI: 10.1039/C3BM60024F, Paper

Jianxun Ding, Fenghua Shi, Di Li, Li Chen, Xiuli Zhuang, Xuesi Chen
The combination of acid-sensitive doxorubicin derivatives with a pH and reduction dual-responsive nanogel exhibited improved chemotherapy security and efficacy.
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Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery

Biomater. Sci., 2013, 1,625-632
DOI: 10.1039/C3BM00169E, Paper

Ying Wang, Melina R. Kibbe, Guillermo A. Ameer
Biodegradable, biocompatible, long-lasting NO-releasing and mechanically strong elastomeric materials have been developed via photo-polymerization of poly(diol citrate)s with miscible diazeniumdiolates.
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On-off switchable drug release from multi-responsive degradable poly(ether urethane) nanoparticles

Biomater. Sci., 2013, 1,614-624
DOI: 10.1039/C3BM00188A, Paper

Yangyun Wang, Guolin Wu, Xiaomeng Li, Yinong Wang, Hui Gao, Jianbiao Ma
An on-off switchable drug-release system was successfully prepared from a series of multi-responsive degradable poly(ether urethane)s.
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The surface charge of anti-bacterial coatings alters motility and biofilm architecture

Biomater. Sci., 2013, 1,589-602
DOI: 10.1039/C3BM00197K, Paper

Olena Rzhepishevska, Shoghik Hakobyan, Rohit Ruhal, Julien Gautrot, David Barbero, Madeleine Ramstedt
Bacterial colonization of abiotic surfaces with differences in physicochemical properties gives rise to different types of bacterial biofilms, with respect to biofilm architecture, biofilm physiology and the amount of biofilm formed.
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Hydrogels formed by oxo-ester mediated native chemical ligation

Biomater. Sci., 2013, 1,603-613
DOI: 10.1039/C3BM00201B, Paper

Iossif Strehin, Dmitri Gourevitch, Yong Zhang, Ellen Heber-Katz, Phillip B. Messersmith
We describe a method to form cross-linked hydrogels under physiologic conditions through oxo-ester mediated native chemical ligation.
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Self-assembled oligomeric procyanidin-insulin hybrid nanoparticles: a novel strategy for controllable insulin delivery

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60066A, Paper

Rui Liu, Li-Bing Wang, Ren-Liang Huang, Rong-Xin Su, Wei Qi, Yan-Jun Yu, Zhi-Min He
Natural oligomeric procyanidin (OPC) with high biological and pharmacological activities was successfully used to synthesize OPC-insulin (OPC-INS) nanoparticles with different aggregation sizes for sustained and controlled delivery of hydrophilic insulin.
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Uptake of poly(2-hydroxypropylmethacrylamide)-coated gold nanoparticles in microvascular endothelial cells and transport across the blood-brain barrier

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60050E, Paper

Christian Freese, Ronald E. Unger, Robert C. Deller, Matthew I. Gibson, Christoph Brochhausen, Harm-Anton Klok, C. James Kirkpatrick
Poly(2-hydroxypropylmethacrylamide)-coated AuNPs are preferably internalized by brain ECs compared to dermal ECs. Uptake and transport of AuNPs are not correlated.
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Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM00004D, Paper

Kyuri Kim, Ji Hyun Ryu, Dong Yun Lee, Haeshin Lee
Mussel-inspired chitosan-catechol exhibits superior water-solubility and adhesiveness to unmodified chitosan, which results in facile formation of hydrogels and layer-by-layer assembly.
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Synthesis, characterization, and in vitro evaluation of two synergistic anticancer drug-containing hepatoma-targeting micelles formed from amphiphilic random copolymer

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60027K, Paper

Jianfeng Wang, Cui Yin, Guping Tang, Xianfu Lin, Qi Wu
Preparation and in vitro evaluation of a galactose-functionalized copolymer as a targeting and multidrug delivery system.
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Bio-ink properties and printability for extrusion printing living cells

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM00012E, Paper

Johnson H. Y. Chung, Sina Naficy, Zhilian Yue, Robert Kapsa, Anita Quigley, Simon E. Moulton, Gordon G. Wallace
A series of techniques are presented to characterise the specific requirements needed to print a 3D scaffold successfully for tissue engineering.
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Competing properties of mucoadhesive films designed for localized delivery of imiquimod

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60064E, Paper

Sandeep K. Ramineni, Larry L. Cunningham, Thomas D. Dziubla, David A. Puleo
Physical, chemical, and mechanical properties of mucoadhesive films were investigated to understand how changes in composition affect selection of materials for a particular application, such as treating oral precancerous lesions.
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Combining BMP-6, TGF-[small beta]3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells

Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C3BM60056D, Paper

Yurong Liu, Conor T. Buckley, Kevin J. Mulhall, Daniel J. Kelly
Identification of a growth factor combination to be used with hydrostatic pressure (HP) stimulation to enhance development of cartilaginous grafts engineered using human infrapatellar fat pad derived stem cells (FPSCs).
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