RSC - Biomater. Sci. latest articles

Modular Noncovalent Functionalization of Electrospun Piezoelectric Scaffolds with Bioactive Nanocarriers

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01563D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sarah Payne Bortel, Sumayia Saif Jaima Chowdhury, Jeremy Cheng, Daniella Uvaldo, Mackenzie Wright, Treena Livingston Arinzeh, Santiago Correa, Anna Kylat
Electrospun scaffolds offer a promising platform for immune-instructive materials, but stable and modular functionalization with bioactive signals remains a technical challenge. Here, we develop a surface coating strategy for electrospun...
The content of this RSS Feed (c) The Royal Society of Chemistry

Multi-enzyme nanozyme targeting redox-senescence-angiogenesis axis ameliorates pathological angiogenesis in retinopathy models

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00015K, Paper

Shuo-Shuo Gu, Ling-Xiao Xia, Yi-Peng Li, Jian-Ying Chen, Ya-Ni Wu, Yu-Hong Cui, Huai-Jie Huang, Jing Meng, Qingsong Mei, Hong-Wei Pan
A biocompatible nanozyme scavenges reactive oxygen species through a non-Fenton mechanism, normalizing pathological retinal vasculature and reducing vascular leakage, presenting a transformative therapeutic strategy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Antimicrobial properties of spray-dried silver–zinc nanozeolite particles and their application in formulating antimicrobial electrospun polymeric fibers

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM00928F, Paper

Qiang Wang, Xiang Xu, Yuxin Yang, Sweta Shrestha, Bo Wang, Xunxi Dong, Zirui Zhang, Runzhe Wu, Yangong Zheng, Xiao Wang, Prabir K. Dutta
Silver-based antimicrobials are used in the consumer, medical and agricultural industries.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

MOF-reinforced NIR-responsive composite hydrogel with photothermal antibacterial and antioxidant activities for diabetic wound healing

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00157B, Paper

Zixin Zhang, Yuxin Wang, Bingjie Sun, Huaqiang Luo, Bingtian Tu, Huan He, Jing Tu
The CEPN hydrogel promotes diabetic wound healing under NIR through antibacterial, antioxidant, and pro-angiogenic effects.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Nanotechnology-mediated metabolic reprogramming for tumour ferroptosis: mechanisms and therapeutic prospects

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00004E, Review Article

Yifan Wu, Xiujun Lai, Xin Jiang, Longfei Liu, Changyang Gong, Furong Liu
Nanotechnology-mediated metabolic intervention may overcome tumour resistance by restoring ferroptosis sensitivity. This review highlights nano-based regulation of iron, lipid, amino acid, and glucose metabolism, and its antitumour potential.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Nanocellulose with Dual Carboxy and Aldehyde Functionality: a Modular Platform for Hydrogel Formation and Sustained Drug Release

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01841B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Emanuela Bua, Chiara Spanu, Giovanni Inzalaco, Martina Zangari, Luca Sartorelli, Letizia Sambri, Elisabetta Venuti, Tommaso Salzillo, Mauro Comes Franchini, Mario Chiariello, Erica Locatelli
Nanocellulose-based hydrogels hold great promise for biomedical applications, particularly as localized drug delivery systems, due to their biocompatibility, tuneable porosity, and soft-tissue mimicking properties. However, most reported systems rely on...
The content of this RSS Feed (c) The Royal Society of Chemistry

Surface Modification of Intraocular Lens with Zwitterionic Poly(Carboxybetaine) for Posterior Capsular Opacification Prevention

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01797A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Wei Wang, Jiqiao Qie, Jiayin Deng, Yuexin Yang, Haijie Han, Ke Yao
Posterior capsular opacification (PCO) remains the most common long-term complication after cataract surgery, primarily caused by residual lens epithelial cells (LEC) adhesion and proliferation on the intraocular lens (IOL) surface....
The content of this RSS Feed (c) The Royal Society of Chemistry

Image-based single-cell isolation in high-density seeded cells using photoactivatable surfaces

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01883H, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shinya Yamahira, Yuki Umeda, Teruyuki Nagamune, Satoshi Yamaguchi
We developed an image-based cell isolation method utilizing a photoactivatable cell anchoring surface. After microscopically imaging the cell population on the substrate, target single cells were selectively and rapidly anchored...
The content of this RSS Feed (c) The Royal Society of Chemistry

A luminescent antibacterial compound targeting Gram-negative bacterial membrane

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01826A, Paper

Shuyu Yang, Yifan Wu, Shang Chen, Meirong Song, Ying Li, Kui Zhu
Infections caused by multidrug-resistant (MDR) Gram-negative bacteria represent a critical global health challenge, necessitating the urgent identification of new antibacterial targets to improve drug discovery and development. In this study,...
The content of this RSS Feed (c) The Royal Society of Chemistry

Tannic Acid-Loaded Mesoporous Silica Particles as Tissue Adhesives for Enhanced Wound Healing

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01919B, Paper

Yeji Jeon, Yeojin Kim, Hee Jin Song, Su Jeong Lim, Suhui Jeong, Hojoon Choi, Jae Hyun Park, Han Sung Youn, D. Seong, Jeonghun Kim, Dae Youn Hwang, Sungbaek Seo
The application of silica nanoparticles as alternatives to commercial cyanoacrylate is limited by their insufficient adhesion strength to tissues. To enhance their adhesion strength, we developed mesoporous silica particles (3.4...
The content of this RSS Feed (c) The Royal Society of Chemistry

pH-responsive polydopamine-shelled 3D-printed chitosan/collagen hydrogel integrating exosomes and an enzyme/peptide cascade for diabetic wound healing

Biomater. Sci., 2026, 14,1332-1355
DOI: 10.1039/D5BM01823D, Paper

Yunxia Du, Di Xiao, Changle Ren, Zhenlan Li, Xiaofeng Wang, Yantao Zhao, Yongmei Jiang
3D-printed chitosan/collagen scaffold with exosomes, EGF, and enzyme/peptide therapeutics. Polydopamine coating enables pH-responsive release at acidic wounds. Antibacterial, antioxidant, anti-inflammatory effects accelerate tissue repair in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigation of nanoscale topography and biomechanical tuning of PDMS substrates to enhance cardiomyocyte differentiation from human induced pluripotent stem cells

Biomater. Sci., 2026, 14,1309-1322
DOI: 10.1039/D5BM01840D, Paper

Fatemeh Etezadi, Mohammad Ali Shokrgozar, Shahin Bonakdar, Kentaro Hayashi, Daniel M. Packwood, Motomu Tanaka, Kouichi Hasegawa
PDMS is still the most widely used biomaterial for bioengineering studies, which can mimic the tissue stiffness and micro/nanostructure to improve the generation and investigation of iCM differentiation from hiPSCs.
The content of this RSS Feed (c) The Royal Society of Chemistry

New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment

Biomater. Sci., 2026, 14,1180-1205
DOI: 10.1039/D5BM01802A, Review Article

Mingkang Shi, Yu Duan, Jiawen Sun, Mengyao Li, Yaxin Wu, Wenbo Zhao, Chun Mao
This review details hydrogen nanomaterial design, synergistic nanoplatform assembly, anticancer advantages, multiple synergistic tumor treatment mechanisms, and effects of hydrogen-based synergistic therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry

tPLGA nanoparticles combined with CCL2/CCR2 inhibitor mitigate post-thrombolytic hemorrhagic transformation

Biomater. Sci., 2026, 14,1249-1261
DOI: 10.1039/D5BM01807B, Paper

Feiyang Luo, Jingmei Pan, Zhenhua Wang, Che Qing, Xi Xiao, Xing Guo, Shaobing Zhou
An MMP-9-responsive tPLGA nanoplatform enables spatiotemporally controlled tPA delivery for targeted thrombolysis. Coupling with CCL2/CCR2 inhibition suppresses neuroinflammation, preserves BBB integrity, and prevents hemorrhagic transformation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Antioxidant nanozymes for periodontal bone regeneration: multifunctional mechanisms and therapeutic applications

Biomater. Sci., 2026, 14,1132-1161
DOI: 10.1039/D5BM01548K, Review Article

Xiaoyi Liu, Ruixue Cheng, Yan Huang, Li Chen, Maolin Li, Ying Xia, Lan Huang, Qi Liu, Kun Yang
Schematic of antioxidant nanozyme mechanisms in periodontitis. Core-shell nanozyme executes: ROS scavenging, targeted antibacterial action, macrophage polarization, and bone regeneration via osteoclast inhibition and osteogenesis/angiogenesis.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synergistic pharmacotherapy for epilepsy: NPY (3–36)-modified ZIF-90 nanoparticles co-delivering GW2580

Biomater. Sci., 2026, 14,1262-1275
DOI: 10.1039/D5BM01868D, Paper

Peipei Cao, Chao Geng, Xinghui Ren, Xiaoqi Chu, Yiting Zhai, Wenyou Li, Changxin Wu
Mechanisms underlying NPY@ZIF-RG synergistic pharmacotherapy for epilepsy.
The content of this RSS Feed (c) The Royal Society of Chemistry

An ROS-responsive antioxidant hydrogel with immunomodulatory activity for promoting diabetic wound healing

Biomater. Sci., 2026, 14,1292-1308
DOI: 10.1039/D6BM00018E, Paper

Yurao Liu, Qianqian Yang, Ling Zhang, Qiyue Lu, Yuhang Li, Haisong Zhang, Chunfang Zhang, Pingli Wu
An ROS-responsive hydrogel was developed. The hydrogel exerts immunomodulatory effects by scavenging ROS. It regulates PPAR, PI3K-AKT, and JAK-STAT signaling pathways for pro-regeneration. This hydrogel represents an ideal diabetic wound dressing.
The content of this RSS Feed (c) The Royal Society of Chemistry

Translational roadmap of BBB-targeted nanoparticle strategies for neuroregenerative therapy in neurodegenerative diseases

Biomater. Sci., 2026, 14,1206-1218
DOI: 10.1039/D5BM01582K, Perspective

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sohui Lee, Jiyeon Lee, Kangwon Lee
We present a translational roadmap for BBB-crossing nanomedicines, integrating transporter-, receptor-, and adsorptive-mediated pathways with disease-specific neuroregenerative demands.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cadherin-11 integrates Piezo1 and interleukin-6 signaling to promote fibroblast activation

Biomater. Sci., 2026, 14,1276-1291
DOI: 10.1039/D5BM01456E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Leilani R. Astrab, Steven R. Caliari
We find that cadherin-11 (CDH11) serves as a key mediator of lung fibroblast activation on hydrogels by coordinating mechanical and inflammatory cues via both Piezo1 and interleukin-6 (IL-6) signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry

Targeting inflammation in hepatocellular carcinoma: emerging nanotherapeutic strategies for remodeling immunosuppressive microenvironments

Biomater. Sci., 2026, 14,1162-1179
DOI: 10.1039/D5BM01798J, Review Article

Hongyan Dong, Meiyu Shao, Zhen Tao, Zikang Wang, Zengguang Gao, Wenxiu Qiu, Mengyun Peng
Hepatocellular carcinoma (HCC) is one of the most severe malignancies in modern society, and is known as an “inflammatory tumor”, rarely benefiting from immunotherapies.
The content of this RSS Feed (c) The Royal Society of Chemistry

Silk fibroin scaffolds loaded with growth factors can reverse liver fibrosis

Biomater. Sci., 2026, 14,1235-1248
DOI: 10.1039/D5BM01314C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jingyi Wang, Zhanbo Wang, Shuo Zhao, Daxu Zhang, Jingjing Hu, Weilong Li, Xiaonan Shi, Shujun Ye, Xiaojiao Liu, Yaopeng Zhang, Li Yan
Silk fibroin scaffolds loaded with growth factors (HGF, FGF-4) reversed chronic liver fibrosis in mice, improving liver function, reducing fibrosis, and promoting tissue regeneration—a promising new approach for treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry

In-depth chiral sensing capability of C-dots in a biomimetic protein-based hydrogel: a probe for chiral recognition applications

Biomater. Sci., 2026, 14,1323-1331
DOI: 10.1039/D5BM01508A, Paper

Sapna Waghmare, Umarfaruk S. Sayyad, Arunavo Chatterjee, Somen Mondal
Carbon dots serve as highly effective probes for both surface and bulk chiral recognition, making them promising tools for biomedical and bioelectronic research.
The content of this RSS Feed (c) The Royal Society of Chemistry

A dual-network Bletilla striata polysaccharide hydrogel for PPAR-mediated macrophage polarization and accelerated diabetic wound healing

Biomater. Sci., 2026, 14,1219-1234
DOI: 10.1039/D5BM01617G, Paper

Shan Yu, Ling Wang, Zhenbo Peng, Yanjun Chen, Peifang Xu
Chronic diabetic wounds remain difficult to heal due to persistent inflammation and impaired macrophage polarization.
The content of this RSS Feed (c) The Royal Society of Chemistry

A precision therapy paradigm for noise-induced hearing loss: integrating transcriptome-guided drug repurposing with in situ hydrogel delivery

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00030D, Paper

Qinming Cai, Mengwen Shi, Jinlin Chen, Chenyang Kong, Xiaoying Wang, Ye Yuan, Junna Lu, Diwei Zheng, Yu Sun
Schematic illustration of the precision therapy paradigm for noise-induced hearing loss (NIHL).
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A Self-Energized Photodynamic Therapy Agent Based on Persistent Luminescence Nanoparticles

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00086J, Paper

Pengfei Lu, Chang Yin, Kai Long, Yuan Tian, Zi-Jin Wei, Yifei Wang, Wei Wang, Zhi Yuan
Photodynamic therapy (PDT), an emerging modality for cancer treatment, faces three major challenges: the limited penetration depth of external light, poor photosensitizer stability, and hypoxia in the tumor microenvironment. Persistent...
The content of this RSS Feed (c) The Royal Society of Chemistry

3D-printed bionic tracheal stents based on tunable triblock thermoplastic copolyester elastomers for tracheal stenosis

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01886B, Paper

Zhaozhong Wang, Wang Yin, Jingwen Hou, Zhu Jin, Shengrong Guo
PCL-PMCL-PCL triblock thermoplastic elastomers with tunable elasticity enable fabrication of bionic tracheal stents featuring cartilage-mimicking surfaces for malignant tracheal stenosis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01544H, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Fátima Santillán, Yasmeen Shamiya, Aishik Chakraborty, Alap Ali Zahid, Lorena Veliz, François Lagugné-Labarthet, Leonard G. Luyt, Arghya Paul
This study introduces an injectable supramolecular hydrogel based on non-covalent interactions between cyclic peptide nanofibers and nanosilicates.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Acidic pH-triggered covalent cross-linking of AIE nanoparticles for enhanced tumor imaging and photodynamic therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01655J, Paper

Weiqi Zai, Huiling Ji, Jincheng Li, Jing Wang, Hongli Chen, Dan Ding, Shenglu Ji, Nannan Wang
Acidic pH-responsive PPP-DBCO nanoparticles (NPs) and PPP-N₃ NPs can undergo specific cross-linking at tumor sites via bioorthogonal reactions, thereby enhancing the fluorescence (Fl) signal and improving photodynamic therapy (PDT) efficacy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

DNA-based hybrid nanoparticles: from design to application in cancer therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01852H, Review Article

Le Zhang, Zhuiyun Li, Wei Tan, Chi Yao, Xiaocui Guo, Dayong Yang
This review highlights DNA-based hybrid nanoparticles for cancer therapy, covering gene editing, energy-activated treatments, immunotherapy and theranostics.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Hardystonite Bioceramic Endowing Multifunctions of Polylactic Acid-Based Composites Favourable for Developing Next-generation Fixation Implants

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01527H, Paper

Jiaqi Yang, Qianshuo Huang, Zeshe Chen, Min Cheng, Jian Shen, Jingqi Zheng, Guojing Yang, Changyou Gao, Sanzhong Xu, Huiming Zhong, Zhongru Gou
Developing multifunctional biodegradable internal fixing implants with appreciable anti-infection is crucial to enhancing their applications in regenerative medicine. Polylactic acid (PLA)-based polymers are attracting much attention in biomedicine because of...
The content of this RSS Feed (c) The Royal Society of Chemistry

Bioactive cationic lipidated oligomers (CLOs) as antimicrobial materials: metabolomic insights into MRSA membrane disruption

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01485A, Paper

Muhammad Bilal Hassan Mahboob, Jessica R. Tait, Dovile Anderson, Maytham Hussein, John F. Quinn, Tony Velkov, Darren J. Creek, Michael R. Whittaker, Cornelia B. Landersdorfer
Untargeted metabolomics uncovers distinct membrane-lipid disruptions in MRSA triggered by two structurally distinct cationic lipidated oligomers (CLOs).
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Rational design of a targeted theranostic nanoagent for sequential application during oral squamous cell carcinoma surgery

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01701G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Danni Shan, Diya Xie, Liping Zeng, Jianquan Wang, Zhiyong Wang
Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck, and its treatment outcome depends strongly on whether the tumor is completely removed during surgery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Betulinic acid exacerbates biomolecular condensation of α-synuclein: Possible role in Parkinson's Disease

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01817J, Paper

Soumojit Biswas, Karthik P, Nimisha A Mavlankar, Asish Pal, Ipsita Roy
Aggregation of α-synuclein (α-SYN) into amyloid structures is closely linked to progression of Parkinson's disease (PD). Type 2 diabetes mellitus increases PD risk, sharing common pathological features like amyloid aggregation,...
The content of this RSS Feed (c) The Royal Society of Chemistry

A thermosensitive hydrogel achieves sustained co-delivery of two therapeutic agents with distinct properties for preventing aseptic loosening

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00096G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yang Wang, Xin Wang, Hongjie Zhang, Yaoben Wang, Hancheng Wang, Zhiyong Chen, Jiandong Ding, Xiaochun Peng, Lin Yu
Wear particle-induced prosthesis aseptic loosening severely affects the longevity of total joint arthroplasty. This condition arises from periprosthetic osteolysis, which is driven by excessive inflammation and enhanced bone resorption under...
The content of this RSS Feed (c) The Royal Society of Chemistry

Multifunctional degradable highly branched–linear poly(β-amino esters) for efficient YAP gene delivery

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01543J, Paper

Linjing Shi, Sen Luo, Zhuo Huang, Weiyi Xu, Hui Li, Chenfei Wang
Optimized H-LPAE demonstrated high YAP gene transfection efficiencies in HSC-1 and SCL-1 cells, while maintaining a superior safety profile.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Engineered Nanoparticle Systems Targeting Tumor Angiogenesis: Bridging Molecular Mechanisms and Therapeutic Innovations

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01787D, Review Article

Swarna Kumari Kanthirigala , Vijayadurga V. V. Lekkala, Lebaka Veeranjaneya Reddy, Madhava C Reddy, Dakshayani Lomada, Tapas K Mandal
Angiogenesis, the formation of new blood vessels from existing vasculature, is a fundamental biological process that becomes dysregulated during tumor progression. In solid tumors, uncontrolled angiogenesis supplies oxygen and nutrients,...
The content of this RSS Feed (c) The Royal Society of Chemistry

Bioinspired scaffold design using a custom Voronoi path generator for Extrusion-based 3D printing

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01834J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Federico Farina, Michela Licciardello, Joanna Babilotte, Chiara Tonda Turo, Gianluca Ciardelli, Lorenzo Moroni
Natural systems are often arranged into specialized patterns conferring unique biological features and functions to tissues and organs. Engineered microenvironments, aiming to support cell cultures and tissue-specific functions, have to...
The content of this RSS Feed (c) The Royal Society of Chemistry

Composite microspheres of bioactive glass and hydrophilic biodegradable polymers to accelerate infected wound healing

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01822F, Paper

Ziyun He, Zirui Xu, Shuhua Chang, Quan Zhao, Zhuangzhuang Zhang, Yun Bai, Ju-E Cun, Jun Cao, Bin He
Hydrophilic Cu-doped bioactive glass composite biodegradable polyurethane microspheres were developed for infected wound repair, neutralizing acidic PLLA by-products and imparting antibacterial/angiogenic effects to accelerate healing.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Self-amplifying ROS nanorobot with orthogonal NIR activation for enhanced photodynamic–chemodynamic combination therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01705J, Paper

Rongjie Gao, Feiyan Chen, Yong Li, Zhengshuai Tang, Jinliang Liu
We developed a hybrid nanorobot combining engineered bacteria and upconversion nanoparticles for self-amplifying ROS generation, inhibiting tumor growth via near-infrared light-triggered bacterial activation and dual-modal PDT/CDT.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Expression of concern: A multifunctional substance P-conjugated chitosan hydrochloride hydrogel accelerates full-thickness wound healing by enhancing synchronized vascularization, extracellular matrix deposition, and nerve regeneration

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM90019D, Expression of Concern

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Hao Li, Mengna Li, Pei Liu, Kaiyang Wang, Haoyu Fang, Junhui Yin, Daoyu Zhu, Qianhao Yang, Junjie Gao, Qinfei Ke, Hongping Yu, Yaping Guo, Youshui Gao, Changqing Zhang
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Correction: A biomimetic human disease model of bacterial keratitis using a cornea-on-a-chip system

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM90008A, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yudan Deng, Lingjun Li, Jian Xu, Yili Yao, Jiangtao Ding, Lei Wang, Chunxiong Luo, Wei Yang, Lingli Li
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Expression of concern: 3D-printed dimethyloxallyl glycine delivery scaffolds to improve angiogenesis and osteogenesis

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM90018F, Expression of Concern

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Zhu Min, Zhao Shichang, Xin Chen, Zhu Yufang, Zhang Changqing
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

In situ induction of multivalent PD-L1 antibody secretion to enhance cancer immunotherapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01896J, Paper

Li-Li Chen, Shi-Kun Zhou, Shui-Qing Jiang, Yi-Qun Sun, Xin-Yu Tan, Yi-Fang Chen, Yang Liu, Zi-Dong Lu, Cong-Fei Xu
A tumor-specific gene nanomedicine enables intratumoral secretion of multivalent PD-L1 antibodies, enhancing checkpoint blockade efficacy through localized immune activation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Injectable self-healing oxidized pectin and carbohydrazide-modified gelatin hydrogels for curcumin-loaded zein nanoparticle delivery in antioxidant therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01302J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Francesca Tivano, Elena Marcello, Camilla Paoletti, Alice Zoso, Clara Mattu, Irene Carmagnola, Valeria Chiono
The design of drug delivery systems (DDS) for efficient and sustained in situ antioxidant treatment is a promising strategy in regenerative medicine applications.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A multiphasic core-shell flurbiprofen and ciprofloxacin-loaded nanofibrous dressing cures infected burns via dual control of infection and inflammatory response

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01645B, Paper

Mohit Kamboj, Jasleen Kaur, Varun Rathi , Simran Preet, Atharva Poundarik, Bodhisatwa Das
Burn injury treatment is usually accompanied by significant challenges, like microbial growth and chronic inflammation. A multifunctional nanofibrous dressing with biphasic chemical properties is fabricated to regulate infection and inflammation...
The content of this RSS Feed (c) The Royal Society of Chemistry

Clickable polyamidosaccharides: accessing bottlebrush inspired hyaluronic acid glycopolymers for CD44 targeting of breast cancer cells

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01613D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kaitlynn A. Sockett, Madeline K. Loffredo, Christian D. DeMoya, Zoe G. Garman, Mark W. Grinstaff
Polyamidosaccharides armed with hyaluronic acid disaccharide branches bind the transmembrane glycoprotein cluster of differentiation-44 (CD44), a highly expressed surface receptor that plays a critical role in tumor growth, invasion, and metastasis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Amphiphilic guanidine-based lipids enhance mRNA delivery and immune activation

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00068A, Paper

Qi Wei, Ruoshui Li, Jiaqi Fan, Mengyuan Xu, Pengcheng Yuan, Jiwei Liu, Qian Wang, Youqing Shen, Nigel K. H. Slater, Jianbin Tang
Guanidine-based lipids (GL) were developed for incorporation into lipid nanoparticles (LNP) to enhance mRNA transfection, immune activation, and spleen-targeted mRNA expression, presenting an innovative method to promote LNP-mediated mRNA delivery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Correction: Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications

Biomater. Sci., 2026, 14,1122-1122
DOI: 10.1039/D5BM90097B, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Islam A. Khalil, Bahram Saleh, Dina M. Ibrahim, Clotilde Jumelle, Ann Yung, Reza Dana, Nasim Annabi
The content of this RSS Feed (c) The Royal Society of Chemistry

Self-enhanced multifunctional nanoplatforms for tumor-specific synergistic therapy via NIR-induced mild photothermal and chemodynamic effects

Biomater. Sci., 2026, 14,1086-1097
DOI: 10.1039/D5BM01539A, Paper

Xi Zhang, Zhiping Song, Yu Han, Jingtong An, Qishan Xu, Xiangyan Chen, Yantao Li
The construction of multifunctional cascade nanoplatforms overcomes the inherent limitations of combined mPTT and CDT, thereby amplifying tumor-specific therapeutic efficacy.
The content of this RSS Feed (c) The Royal Society of Chemistry

Oxygen carriers: core strategies for modulating hypoxic microenvironments and promoting healing in chronic wounds

Biomater. Sci., 2026, 14,990-1008
DOI: 10.1039/D5BM01572C, Review Article

Meilin Liu, Yuzhi Chen, Kai Zhu, Shiyu Tao, Yao Xiao, Lian Zhao, Lianju Ma
This review summarizes oxygen carriers based on perfluorocarbons and hemoglobin for chronic wound therapy, compares their O₂ delivery capacities, analyzes synergistic biological effects, and describes challenges in clinical translation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Injectable crosslinked recombinant collagen nanofiber implants enable robust regenerative repair of photoaged skin

Biomater. Sci., 2026, 14,1110-1121
DOI: 10.1039/D5BM01715G, Paper

Nannan Wei, Yuchen Zhang, Xinyu Tian, Linyan Yao, Jianxi Xiao
An injectable THPC-crosslinked recombinant collagen nanofiber implant enables durable ECM reconstruction and effective repair of UV-induced photoaged skin.
The content of this RSS Feed (c) The Royal Society of Chemistry

Calotropis procera flower extracts: a green approach to zinc oxide with a pineapple-like nanoleaf morphology for biological applications

Biomater. Sci., 2026, 14,1098-1109
DOI: 10.1039/D5BM00929D, Paper

Karuvelan Murugan, Udayadasan Sathiskumar, Rajakannu Subashini, Ramachandran Chelliah, Govindasamy Hariharan, Mohan Vedhanayagam, Narasimman Selvakumar
Water contamination can trigger Escherichia coli (E. coli) infections, which are extremely harmful to humans.
The content of this RSS Feed (c) The Royal Society of Chemistry

Engineering delivery platforms for controlled nitric oxide release

Biomater. Sci., 2026, 14,936-951
DOI: 10.1039/D5BM01825K, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sang-Hun Choi, Chae Yeon Han, Kyeong Jin Cho, Kangmin No, Jihoon Kim
This review categorize NO donors into stable and unstable forms, evaluate their merits, and explore strategies for incorporating them into drug delivery systems.
The content of this RSS Feed (c) The Royal Society of Chemistry

Norharmane-loaded bacterial cytoplasmic membrane-coated nanoparticles synergistically enhance polymyxin B against Pseudomonas aeruginosa infections by disrupting biofilms

Biomater. Sci., 2026, 14,1009-1022
DOI: 10.1039/D5BM01571E, Paper

Meilin Qiao, Licheng Gao, Ruibing Yu, Jianwei Chen, Xuanrong Sun, Yue Cai
PMφ-PLGA-NOR efficiently penetrates biofilms via homologous targeting and PMB–LPS interaction, enhancing NOR delivery, disrupting biofilms, and synergistically improving pneumonia treatment with PMB.
The content of this RSS Feed (c) The Royal Society of Chemistry

Glutathione-activatable bola dendrimers mediate tumor-specific cytosolic siRNA delivery via dynamic thiol–disulfide exchange

Biomater. Sci., 2026, 14,1073-1085
DOI: 10.1039/D5BM01643F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Dandan Zhu, Huiling Zhu, Yaoyun Yu, Junyue Zheng, Xianhui Lin, Huimin Cheng, Aoxue Mei, Ming Chen, Yun Li, Haijuan Dong, Jiehua Zhou, Juan Liu, Xiaoxuan Liu
A glutathione-activatable bola amphiphilic peptide dendrimer exhibits excellent tumor-specific cytosolic siRNA delivery performance with optimized thiol-mediated cellular uptake via dynamic thiol–disulfide exchange.
The content of this RSS Feed (c) The Royal Society of Chemistry

A charge-reversal prodrug activated by tumor-acidity for selective cancer chemotherapy

Biomater. Sci., 2026, 14,1052-1061
DOI: 10.1039/D5BM01682G, Paper

Bing Liu, Guanchun Wang, Quanjun Yang, Yang Yu, Yue Su, Wei Huang, Ping Wang, Deyue Yan, Ping Huang
The charge-reversal prodrug PIX-DMMA, activated by tumor acidity, enhances cellular uptake and anticancer efficacy while reducing systemic toxicity.
The content of this RSS Feed (c) The Royal Society of Chemistry

A pH-ultrasensitive membranolytic polymer-assisted delivery system for enhanced siRNA delivery

Biomater. Sci., 2026, 14,1062-1072
DOI: 10.1039/D5BM01235J, Paper

Yue Yu, Houbing Zhang, Xianzhu Yang, Jun Wang, Menghua Xiong, Xiaojiao Du
A pH-ultrasensitive membranolytic polymer-based delivery system facilitates the endosomal escape of siRNA.
The content of this RSS Feed (c) The Royal Society of Chemistry

Dental plaque biofilm-targeting composite nanomaterials: advances and outlook

Biomater. Sci., 2026, 14,952-989
DOI: 10.1039/D5BM01747E, Review Article

Jiaxuan Zhao, Shengyuan Huang, Yongjia Yang, Jilei Wang, Qianqian Guo, Yueming Xu, Bingyin Jiang, Jiang Lin
This review summarizes next-generation nanomaterials targeting dental plaque biofilms in periodontitis, highlighting nanomaterials that restore microbial balance and enable precision therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry

A multiple-responsive nano-prodrug combining chemo-differentiation–cancer stem cell inhibition toward triple-negative breast cancer

Biomater. Sci., 2026, 14,1034-1051
DOI: 10.1039/D5BM01254F, Paper

Yanting Li, Mengdan Ning, Haoping Long, Jiayi Zuo, Jinqiu Liang, Ting Yuan, Feng Cao, Yong Yin, Feng Jiang
Multi-stimuli-responsive nanoprodrug implementing a “chemo-differentiation–cancer stem cell inhibition” strategy toward triple-negative breast cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry

A superhydrophilic zwitterionic hydrogel coating for enhancing long-term anti-bacterial adhesion and anti-encrustation properties of ureteral stents

Biomater. Sci., 2026, 14,1023-1033
DOI: 10.1039/D5BM01692D, Paper

Zhenqing Li, Jiawei Li, Lei Qian, Ye Tian, Haoyu Jin, Peng Yu, Zhengao Wang, Chengyun Ning, Jinxia Zhai
The PTO coating forms a hydration layer by strongly binding water molecules through ionic solvation effects, which shows inhibition of encrustation and bacterial adhesion.
The content of this RSS Feed (c) The Royal Society of Chemistry

Iron-based nanomaterials for tumor therapy: structural engineering and functional mechanisms

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01713K, Review Article

Afeera Saghir, Yunxiu Zhang, Qingyan Jia, Mishal Hameed, Peng Li
Iron-based nanomaterials integrate chemodynamic and ferroptotic mechanisms with magnetic hyperthermia to generate ROS and heat, enabling synergistic tumor cell killing, immune activation, and suppression of tumor progression.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Calcium-binding PLGA microparticles releasing rhBMP-2 for enhancement of bone healing with minimal ectopic bone formation in spine fusion

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01536G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Minjae Kim, Jungwoo Kim, Minji Kang, So Hee Nam, Chi Heon Kim, Yan Lee, Sung Bae Park
We designed a delivery vehicle that locally maintains recombinant human bone morphogenetic protein-2 (rhBMP-2) at bone surgery sites to enhance bone healing while minimizing excessive bone formation at non-targeted sites.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Editorial for the ESB 2025 collection

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM90004F, Editorial

Silvia Farè, Gianluca Ciardelli, Nicholas J. Dunne, Maria E. Southall
Silvia Farè, Gianluca Ciardelli, Nicholas J. Dunne and Maria E. Southall introduce the Biomaterials Science themed European Society for Biomaterials (ESB) 2025 collection.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Chemical engineering strategies to enhance mRNA–LNP stability for therapeutic applications

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01635E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ze Zhang, Yen Hui Ong, Bowei Yang, Bangda Fan, Yi Yan Yang, Qianqian Ni
This review highlights chemical engineering approaches for enhancing the in vivo stability of mRNA–LNP, including sequence engineering, chemical modification, structural optimization and formulation improvement.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry