RSC - Biomater. Sci. latest articles

Microparticle uptake reduces efferocytic capacity of macrophages

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01447F, Paper

Shivangi Mishra, Bharti Aggarwal, Prem Singh Anant, Avinash Bajaj, Siddharth Jhunjhunwala
Uptake of large (~3 µm) sized particles affects efferocytosis capacity of macrophages.
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Inflammation-responsive hierarchical delivery of anti-inflammatory siRNA and peptide alleviates cytokine storm in pneumonia

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01911G, Paper

Xiaohui Li, Shanzhou Duan, Jiandong Yang, Chunxian Piao, Yang Zhou, Chenglong Ge, Qiujun Liang, Minhyung Lee, Lichen Yin, Yongbing Chen
Inflammation-responsive nanocomplexes (NCs) capable of penetrating both the mucus and cytomembrane barriers were developed for acute lung injury treatment through siRNA-mediated TNF-α silencing and RBP-mediated RAGE blocking.
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Tuning hydrogel properties and Schwann cell behavior through microchannel size control in magnetically templated hydrogels

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01573A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Victor G. Rivera-Llabres, Zoe A. Fields, Hayden J. Good, Elizabeth L. Aikman, Stephanie Manrique, Adeline Schmidt, Eleana Manousiouthakis, Whitney L. Stoppel, Christine E. Schmidt, Carlos M. Rinaldi-Ramos
Peripheral nerve injury is a common condition and the development of materials that enhance Schwann cell migration to aid in regeneration is critical as the body has a limited ability to repair transected nerves.
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Hybrid cell membrane-conjugated photosensitive hydrogels as a tumor vaccine for promoting cancer immunotherapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00261G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chaoying Wang, Tao Wang, Wenxin Zhou, Yanxu Li, Weiben Ji, Shengyi Wu, Yutao Feng, Lai Chang, Quan Zhang, Wei Wu
Mechanism of preventive tumor vaccines based on hydrogel system.
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Slippery lubricant-infused surfaces with anti-fouling and antimicrobial properties for preventing biofouling in biomedical applications

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00212A, Minireview

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Grace H. Nguyen, Elizabeth J. Brisbois
This review evaluates slippery lubricant-infused surfaces (SLIPS) as anti-fouling and antimicrobial coatings, contrasting traditional, smart, and bioactive designs for preventing infection, thrombosis, and device failure.
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Plasmonic fluorescent Ag/C-based nanohybrids for treatment of chemically-induced cutaneous burns

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01540E, Paper

Halyna Kuznietsova, Iryna Byelinska, Arsen Ishchuk, Vladimir Lysenko, Alexander Zaderko, Yury V. Ryabchikov, Olga Pylypova, Kostiantyn Paliienko, Nataliia Dziubenko
Silver nanoparticle/carbon dot nanohybrids (Ag/C NHs) aid healing in rat burn models: Ag/C197 enhances early repair in acidic burns, while Ag/C195 improves later-stage healing, reduces inflammation, and supports regeneration.
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Brush-like copolymer and MXene-functionalized PVA/PEEK scaffolds: enhancing lubrication in metatarsophalangeal joint prostheses

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01375E, Paper

Jian Pu, Nengshen Zhang, Luyao Tang, Zemin Ling, Chao Zhang, Jian Song
Inspired by mechanisms in nature, a PVA-based composite that achieves ultra-low friction (COF = 0.033) for MTP implants has been developed by combining brush-like copolymer lubrication with shear-released MXene nanosheets.
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Functionalized collagen-based sponge dressing integrating negative pressure wound therapy and photothermal antibacterial treatment for advanced wound management

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00297H, Paper

Jiaqi Zhou, Jingjing Yu, Tianshuo Hu, Jingyi Li, Cuicui Ding, Lihui Chen, Hui Wu, Min Zhang
A GO/PVA/COL composite sponge fabricated via low-temperature foaming integrates wet-state mechanical robustness, photothermal antibacterial activity, and NPWT compatibility to significantly accelerate infected wound healing.
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Folic Acid-Targeted PLGA Nanoparticles Co-delivering Doxorubicin and MnTPP Enable Ultrasound-Triggered Synergy and Apoptosis in Nasopharyngeal Carcinoma

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01648G, Paper

Min Zhang, Chunmiao Chen, Dandan Sun, Dayan Yang, Lingling Qin, Yanhua Cui, Xiangxiang Jing
Although the co-delivery of chemotherapeutic agents and sonosensitizer has been studied for years, developing an efficiency co-delivery nanocarrier that combine chemotherapy and sonodynamic therapy (SDT) with precise targeting remains a...
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Functional peptide-assisted delivery of CRISPR/Cas9: Recent progress on gene editing

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00231E, Review Article

Hye Min Cho, Yeong Chae Ryu, Min Kyu Cho, Byeong Hee Hwang
The CRISPR/Cas9 system has transformed the field of genome engineering by enabling precise and programmable modification of genomic sequences. Despite its remarkable potential, efficient and safe delivery of CRISPR/Cas9 components...
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Engineering immunostimulatory nanocarriers: TLR7-agonist conjugated poly(beta-amino ester) mRNA delivery systems

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01812A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Hulya Bayraktutan, Amr ElSherbeny, Rafał J. Kopiasz, Charlotte Galley, Nurcan Gumus, Clare L. Bennett, Cameron Alexander, Pratik Gurnani
Adjuvanted mRNA polyplex enhances their immunostimulatory effect.
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Zinc-chelated cuttlefish ink melanin nanoparticle-complexed sprayable chitosan-based hydrogel for promoting infected wound healing

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00302H, Paper

Ruimin Zhan, Lu Liu, Yan Shi, Jinrui Li, Dandan Jing, Mengyang Mao, Qian Yu, Siyi Tong, Hu Hou, Hui-Min David Wang, Zhiguo Wang, Ming Kong
The HGM@Zn²⁺ sprayable hydrogel dressing markedly accelerates the healing process of infected wounds by synchronizing photothermal antibacterial activity, antioxidative capacity, and proangiogenic properties.
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Mechanistic Study on SIRT3/RORγt/STAT3-Regulated Th17-Targeted Bionic Black Phosphorus Quantum Dot Cluster Nanozyme for Improving Sepsis-Associated Acute Kidney Injury

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5BM01669J, Paper

Qinbiao Chen, Yanli Ma, Yuewu Tang, Ni Du
Sepsis-related acute kidney injury (SA-AKI) represents a severe complication associated with elevated mortality rates, primarily driven by imbalanced Th17 immune responses and mitochondrial dysfunction. Consequently, there is an urgent need...
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Biofabrication of 3D-printed fibrous scaffolds for large muscle tissue engineering: enhancing scalability, myotube formation and surgical handling

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01465D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Eva Schätzlein, Oliver Weeger, Sebastian Scholpp, Leon Faulhaber, Anna Fritschen, Jamina Sofie Gerhardus, Robin Maatz, Annabelle Neuhäusler, Souraj Mandal, Regine von Klitzing, Andreas Blaeser
A multimodal 3D-bioprinting process for fabrication of muscle precursors with high suture retention strength and biofunctionality.
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Thermoresponsive hydrogels for controlled drug delivery to the back of the eye: a data-driven guide to formulation design

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00104A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alexa K. Beathard-Wojan, Vibhuti Agrahari
This study comprehensively evaluates intravitreal thermoresponsive, drug-loaded hydrogels, highlighting how polymer composition and therapeutic class influence mechanical properties, safety, and release to guide rational formulation design.
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Simvastatin attenuates endothelial dysfunction in a coronary artery-on-a-chip

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00327C, Paper

Jasneil Singh, Deepu Ashok, Henry Howard, Steven G. Wise, Anna Waterhouse
A coronary artery-on-a-chip mimics shear-dependent endothelial dysfunction and immune cell adhesion at bifurcations, which are reversed following simvastatin treatment (scale = 100 µm).
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Correction: Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM90034H, Correction

Open Access

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Nianqiang Jin, Nuo Jin, Zilin Wang, Lili Liu, Lin Meng, Daowei Li, Xing Li, Dabo Zhou, Jie Liu, Wenhuan Bu, Hongchen Sun, Bai Yang
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Targeting bacterial metal dependence: material design with computational frontiers

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00475J, Review Article

Liwen Zhang, Yang Zhu, Xiaokai Jiang, Binyao Dai
Antimicrobial resistance (AMR) constitutes a profound global health crisis, necessitating the development of unconventional therapeutic targets. Bacterial reliance on transition metals for metabolism, virulence, and survival creates a conserved, underexploited...
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PINK1/Parkin-dependent mitophagy regulates macrophage polarization and osseointegration of titanium implant in inflammatory microenvironments

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00101G, Paper

Jiali Deng, Zhengchuan Zhang, Yang Yang, Yinghong Zhou, Siuman Leung, Jinming Wang, Cuizhu Tang
PINK1/Parkin-dependent mitophagy drives M2 macrophage polarization, and its activation by rapamycin enhances titanium implant osseointegration under inflammation.
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Microfluidic co-assembly of PEG/PEG-lipid-incorporated PBAE nanoparticles for enhanced non-viral gene delivery

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00153J, Paper

GuoJing Pei, MengRu Kang, Kang Du, YanJie Liang, Wen Zhang, DongQi Tang
This microfluidic co-assembly strategy enables efficient gene delivery to non-activated primary T cells, addressing a key limitation in immune cell engineering.
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Photothermal self-adjuvant porous microneedles for self-healing encapsulation and sustained release of antigens to improve adaptive immunity

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01847A, Paper

Xin Wang, Zhiming Li, Jiahui Fu, Xueyu Wen, Zhenni Chen, Shaohua Li, Tianqi Liu, Fei Jia, Hao Chang
Photothermal porous microneedles enable rapid self-healing antigen encapsulation and sustained intradermal release. Local NIR-triggered hyperthermia acts as a physical adjuvant, eliciting potent and durable antigen-specific immunity and memory.
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Regenerative cerium oxide nanozyme for cataract treatment via oxidative stress regulation

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00331A, Paper

Hongying Xie, Yajia Wang, Jiahao Wang, Zhenbiao Xu, Chunyi Weng, Quankui Lin
As the world's leading blinding eye disease, cataract pathogenesis is closely related to reactive oxygen species (ROS)-mediated oxidative damage to the lens. Surgical intervention has limitations, necessitating non-invasive antioxidant treatment...
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A GMP-compliant formulation of regeneratively active polyphosphate for wound healing and skin regeneration

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00151C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Werner E G Müller, Meik Neufurth, Xiaoqin La, Hadrian Nassabi, Mathias Brösicke, Rita Dobmeyer, Rafael Munoz-Espi, Changxin Wu, Hiroshi Ushijima, Heinz Christoph Schröder, Xiaohong Wang
Inorganic polyphosphate (polyP) is a metabolically relevant biopolymer involved in cellular energy storage and ATP-dependent tissue repair, including skin regeneration and wound healing. Here, a GMP-compliant sodium polyphosphate formulation (Na-polyP-GMP)...
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MOF-based arginine nanocarriers for coordinated immunometabolic and antitumor modulation in triple negative breast cancer

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00195E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Amir M. Alsharabasy, Aibhe Boran, Roberto González-Gómez, Harry Revill, Abhay Pandit, Pau Farràs
MOF-based arginine nanocarriers enable controlled nitric oxide generation, with enhancing T-cell metabolism and suppressing TNBC cell migration, demonstrating a dual immunometabolic and antitumor strategy.
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3D-Printed lesion-conformal light-guiding patches for precise and personalized psoriasis phototherapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00209A, Paper

Yiran Wang, Lin Mei, Tao Wan, Yizhang Fu, Xingzheng Xue, Wen Guo, Yingying Wang, Yi Zhao, Ran Liu
A 3D-printed flexible TiO₂NP-PDMS waveguide patch conforms to irregular psoriatic lesions for precise 308 nm UV phototherapy, ensuring robust therapeutic outcomes while strictly protecting healthy skin.
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Early diagnosis of fibrogenic remodeling in idiopathic pulmonary fibrosis by targeting matrix metalloproteinase-2 with CT imaging

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM00916B, Paper

Qingwen Xu, Bowei Li, Chaochao Zhang, Yuyao Sun, Mengli Song, Ying Li, Lihua Li, Yan Wang, Chenggong Yu
A matrix metalloproteinase-2 (MMP-2) activatable nanoprobe, designated as MSNPs, facilitates the accumulation of localized contrast agents and enables the precise localization of early fibrotic lesions through computed tomography (CT) imaging.
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Thermo-sensitive poly(L-methionine) hydrogel facilitates regenerative repair of diabetic wounds by modulating immune microenvironments

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01781E, Communication

Mengtian Xie, Yirong Sun, Jianxun Ding
EG₄₅Met₂₅ promotes chronic wound repair and appendage regeneration through synergistic antioxidant and anti-inflammatory effect mechanisms.
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Self-sustaining media-reconstituted GelMA bioink supports printable hematopoietic cultures

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01004G, Paper

Noah S. Pereira, Jacob Quint, Evelyn Mollocana-Lara, Mohamadmahdi Samandari, Farnoosh SaeediNejad, Mikaela Kutrolli, Cooper Cassells, Erin McEwen, Bernd Simon, Ali Tamayol, Vanessa Scanlon
Tunable, bioprintable hydrogels are essential for mechanistic studies of hematopoietic stem and progenitor cell (HSPC) fate because stiffness, porosity, and dimension of culture are crucial for HSPC expansion and differentiation.
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Deconstructing culture media reveals a key role of oxyanion salts on the physicochemical properties of ortho-aminomethyl-phenylboronic acid/glucamine hydrogels in aqueous environments

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01473E, Paper

Léa Terriac, Khaled Alsabi, Elise Patingre, Ewen Tertrin, Yves Maugars, Catherine Garnier, Jean-Jacques Helesbeux, Vianney Delplace
Differences in the physicochemical properties of some boronate ester hydrogels in various aqueous media are driven by oxyanion salts, which influence gelation, stiffness, and stability in an ion-specific manner.
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Retina-targeted siRNA delivery via exosome-liposome hybrid vesicles for AMD treatment

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00090H, Paper

Yangyang Huang, Xingyu Zhu, Ruiyang Lu, Kai Jiang, Lijuan Zhu, Xujiao Zhou, Jiaxu Hong, Chuan Zhang
Effective treatment of neovascular age-related macular degeneration (AMD) requires targeted inhibition of vascular endothelial growth factor (VEGF) within the retina. However, delivering therapeutic siRNA to the retinal pigment epithelium (RPE),...
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Recent advances in hemoperfusion adsorbents: From material innovations to emerging application systems

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00131A, Review Article

Xinjie Liu, Fanling Meng, Liang Luo
Hemoperfusion has become an important blood purification modality in critical illnesses, renal failure, liver disorders and sepsis. Due to its ability to remove different toxins from the blood using special...
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Correction: Injectable hydrogels activated with copper sulfide nanoparticles for enhancing spatiotemporal sterilization and osteogenesis in periodontal therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM90011A, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yuting Yang, Chunbin Xu, Shengqian Xu, Yan Li, Ke'er Chen, Tao Yang, Jiaqi Bao, Yajing Xu, Jingyao Chen, Chuanbin Mao, Lili Chen, Weilian Sun
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Function of the material–tissue interface in peripheral nerve regeneration: physical and chemical properties, functionalization and intellectualization

Biomater. Sci., 2026, 14,1948-1962
DOI: 10.1039/D6BM00117C, Review Article

Qi Meng, Meng Zhang, Miaotian Tang, Haoran Jiang, Yang Qu, Zhentao Ding, Jinqiu Tian, Haoran Zhang, Chenyujun Hu, Zhihao Lin, Bohan Xing, Bojiang Wang, Peixun Zhang
This article reviews the pivotal role of material–tissue interfaces in peripheral nerve regeneration, including their physicochemical properties, surface functionalization strategies, and intelligent design approaches.
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Advances in the application of metal–organic frameworks in ophthalmology

Biomater. Sci., 2026, 14,1930-1947
DOI: 10.1039/D5BM01641J, Review Article

Teng Liu, Yi-fan Liao, Jian-xiao Liu, Yu-peng Zhang, Yu-lin Yu, Tong Wang, Zi-xia Wu, Zhi-peng You
The summary scheme, advantages, applications and challenges of MOFs in ophthalmology.
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A self-assembled HSA–ICG nanoprobe enables accurate photoacoustic thermometry and feedback-controlled tumor photothermal therapy

Biomater. Sci., 2026, 14,2113-2124
DOI: 10.1039/D5BM01723H, Paper

Yiming Ma, Han Gong, Xudong Luo, Yuelin Han, Guojun Huang, Hong Pan, Lintao Cai, Mingjian Sun
A self-assembled albumin–ICG nanoprobe is presented for photoacoustic temperature monitoring and feedback-assisted photothermal tumor treatment, supporting controlled temperature regulation of tumors in vivo.
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Ciprofloxacin–polymer conjugates targeted with iron(III) for effective treatment of intracellular bacterial infections

Biomater. Sci., 2026, 14,2125-2136
DOI: 10.1039/D6BM00145A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Anna Stehlíková, Lenka Kotrchová, Michal Pechar, Kristýna Gunár, Eliška Rydvalová, Martin Studenovský, Tomáš Etrych
The increasing prevalence of multidrug-resistant bacteria necessitates innovative antibiotic strategies beyond the discovery of new active compounds.
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Correction: Facilely printed silk fibroin hydrogel microparticles as injectable long-lasting fillers

Biomater. Sci., 2026, 14,2141-2141
DOI: 10.1039/D6BM90009G, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Chunyu Xie, Xiao Yang, Fan Zheng, Jiahao Shi, Caixia Huo, Zuyuan Wang, Rui L. Reis, Subhas C. Kundu, Bo Xiao, Lian Duan
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Correction: “Hot-dog-string” drug-eluting degradable stents for treating stenosis in tortuous arteries

Biomater. Sci., 2026, 14,2140-2140
DOI: 10.1039/D6BM90024K, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Chen-Hung Lee, Pin-Chao Feng, Shih-Jie Hsu, Yi-Hua Kuo, Shih-Jung Liu
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A heparin-functionalized scaffold loaded with pleiotrophin enhances endothelialization and angiogenic potential in liver tissue engineering

Biomater. Sci., 2026, 14,2057-2076
DOI: 10.1039/D5BM01589H, Paper

Chandra Jit Yadav, Usha Yadav, Sadia Afrin, Jun-Yeong Lee, Jihad Kamel, Kyung-Mee Park
Pleiotrophin-loaded heparin-functionalized scaffolds enhance endothelialization, promote angiogenesis, and improve vascular integration for liver tissue engineering.
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Correction: MnO2-based nanoparticles remodeling tumor micro-environment to augment sonodynamic immunotherapy against breast cancer

Biomater. Sci., 2026, 14,2139-2139
DOI: 10.1039/D6BM90020H, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Haiqin Liao, Mingyu Chen, Zhipeng Liao, Yi Luo, Sijie Chen, Long Wang, Zhigang Wang, Chengcheng Niu
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Correction: Tumor-triggered personalized microRNA cocktail therapy for hepatocellular carcinoma

Biomater. Sci., 2026, 14,2137-2138
DOI: 10.1039/D6BM90010K, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Shiyi Shao, Qida Hu, Wangteng Wu, Meng Wang, Junming Huang, Xinyu Zhao, Guping Tang, Tingbo Liang
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The increase in the pore size of gelatin methacryloyl (GelMA) macroporous hydrogel promotes cell proliferation by enhancing substance permeability

Biomater. Sci., 2026, 14,1978-1995
DOI: 10.1039/D5BM01628B, Paper

Ruirui Ding, Zhe Wang, Yuwen Wang, Bo Du, Ruiping Duan, Xuemin Li, Lingrong Liu
A quantitative transport model is established for GelMA macroporous hydrogels. Enhanced permeability supports BMSC proliferation alongside improved glucose uptake and ATP production, offering a theoretical basis for optimized scaffold design.
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Modular noncovalent functionalization of electrospun piezoelectric scaffolds with bioactive nanocarriers

Biomater. Sci., 2026, 14,1963-1977
DOI: 10.1039/D5BM01563D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sarah Payne Bortel, Sumayia Saif Jaima Chowdhury, Jeremy Cheng, Daniella Uvaldo, Mackenzie Wright, Anna Marie Kylat, Treena Livingston Arinzeh, Santiago Correa
Novelty: Piezoelectric scaffolds can be coated with both polymeric nanoparticles and soft nanocarriers such as liposomes without requiring covalent surface modification.
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Nanocellulose with dual carboxy and aldehyde functionality: a modular platform for hydrogel formation and sustained drug release

Biomater. Sci., 2026, 14,2027-2038
DOI: 10.1039/D5BM01841B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Emanuela Bua, Chiara Spanu, Giovanni Inzalaco, Martina Zangari, Luca Sartorelli, Letizia Sambri, Elisabetta Venuti, Tommaso Salzillo, Mauro Comes Franchini, Mario Chiariello, Erica Locatelli
Novel bifunctional crystalline nanocellulose bearing both carboxy and dialdehyde groups allows for diamine-based crosslinking for tuneable drug-delivery hydrogels formation.
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Surface modification of intraocular lenses with zwitterionic poly(carboxybetaine) for posterior capsular opacification prevention

Biomater. Sci., 2026, 14,2106-2112
DOI: 10.1039/D5BM01797A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Wei Wang, Jiqiao Qie, Jiayin Deng, Yuexin Yang, Haijie Han, Ke Yao
A zwitterionic CBMA coating grafted onto IOLs creates a highly antifouling surface that inhibits lens epithelial cell adhesion and fibrosis, suppressing posterior capsular opacification.
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Tannic acid-loaded mesoporous silica particles as tissue adhesives for enhanced wound healing

Biomater. Sci., 2026, 14,2077-2089
DOI: 10.1039/D5BM01919B, Paper

Yeji Jeon, Yeojin Kim, Hee Jin Song, Su Jeong Lim, Suhui Jeong, Hojoon Choi, Jae Hyun Park, Han Sung Youn, Dong Gi Seong, Jeonghun Kim, Dae Youn Hwang, Sungbaek Seo
Tannic acid-loaded mesoporous silica particles treatment provided improved wound closing with reduced inflammatory response during wound healing process.
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A luminescent antibacterial compound targeting Gram-negative bacterial membranes

Biomater. Sci., 2026, 14,2090-2105
DOI: 10.1039/D5BM01826A, Paper

Shuyu Yang, Yifan Wu, Shang Chen, Meirong Song, Ying Li, Kui Zhu
A novel antibacterial agent, TTCVP, selectively targets bacterial inner membranes by binding to phospholipid fatty acid side chains. It disrupts the proton motive force, induces intracellular ROS accumulation, and ultimately leads to bacterial death.
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A self-energized photodynamic therapy agent based on persistent luminescence nanoparticles

Biomater. Sci., 2026, 14,1996-2007
DOI: 10.1039/D6BM00086J, Paper

Pengfei Lu, Chang Yin, Kai Long, Yuan Tian, Zijin Wei, Yifei Wang, Wei Wang, Zhi Yuan
Persistent luminescence nanoparticle-based photodynamic therapy nanoparticles enable post-excitation ROS generation for 48 hours, achieve TME-responsive action and alleviate tumor hypoxia.
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Hardystonite bioceramic-endowed multifunctions of polylactic acid-based composites favourable for developing next-generation fixation implants

Biomater. Sci., 2026, 14,2008-2026
DOI: 10.1039/D5BM01527H, Paper

Jiaqi Yang, Qianshuo Huang, Zeshe Chen, Min Cheng, Jian Shen, Jingqi Zheng, Guojing Yang, Changyou Gao, Sanzhong Xu, Huiming Zhong, Zhongru Gou
A biodegradable PLA composite with integrated low-crystalline Na-doped HAR, featuring controllable degradation, osteogenesis, and antibacterial effects.
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A thermosensitive hydrogel achieves sustained co-delivery of two therapeutic agents with distinct properties for preventing aseptic loosening

Biomater. Sci., 2026, 14,2039-2056
DOI: 10.1039/D6BM00096G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yang Wang, Xin Wang, Hongjie Zhang, Yaoben Wang, Hancheng Wang, Zhiyong Chen, Jiandong Ding, Xiaochun Peng, Lin Yu
An injectable hydrogel system composed of amphiphilic copolymers could continuously co-deliver two agents with distinct properties, generating a synergistic effect that effectively inhibited wear particle-induced aseptic inflammation and osteolysis.
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Engineered nanoparticle systems targeting tumor angiogenesis: bridging molecular mechanisms and therapeutic innovations

Biomater. Sci., 2026, 14,1876-1907
DOI: 10.1039/D5BM01787D, Review Article

Swarna Kumari Kanthireegala, Vijaya Durga V. V. Lekkala, Veeranjaneya Reddy Lebaka, Madhava C. Reddy, Dakshayani Lomada, Tapas Kumar Mandal
Angiogenesis, the formation of new blood vessels from existing vasculature, is a fundamental biological process that becomes dysregulated during tumor progression.
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Silver nanoclusters with near-infrared-II emission: synthesis, properties, and biomedical applications

Biomater. Sci., 2026, 14,1908-1929
DOI: 10.1039/D5BM01870F, Review Article

Zhiming Deng, Jiayou Tao, Yao Huang, Xingwang Wen
Overview of AgNCs with NIR-II emission: optimization strategies for enhanced emission and applications in biological imaging.
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Colon microenvironment restorative nano-armored probiotics–rosmarinic acid bioconjugation for synergistic alleviation of inflammatory bowel disease

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00320F, Paper

Pengyu Chen, Pandi Peng, Junru Wang, Xia Zhang, Yuxin Guo, Hao Yan, Boyi Wang, Kaiyu Zhang, Chunyang Liu, Tao Feng, Peng Li
We developed a nano-armored probiotics–rosmarinic acid bioconjugation (EcN-RA@AS/SA), which is capable of effectively delivering probiotics via oral administration and alleviating inflammatory bowel disease (IBD).
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Macrophage polarization-regulating hydrogels for bone regeneration

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00283H, Review Article

Tianyu Cao, Kaihua Li, Wei Ji, Qifan Yu, Mengping Xu, Tian Qin, Heng Sun, Bin Li
Macrophage-regulating hydrogels enable bone repair by promoting M1-to-M2 phenotype transition. This review covers design strategies, macrophage-osteoblast interactions, and applications in normal and pathological bone defects.
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Synergic cancer chemo-immunotherapy comprising combined doxorubicin and siRNA targeting CD47 co-delivered by a bola-amphiphilic dendrimer

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00031B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Baoping Lian, Dandan Zhu, Peng Chen, Zhihui Wang, Fanzhen Meng, Ran Yan, Nikolay A. Pyataev, Xiaoxuan Liu
Restoring antitumor immunity while enhancing the chemotherapy efficacy represents an optimistic strategy for cancer treatment.
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Engineering immune-evasive islet replacement: cell-intrinsic and peri-graft strategies

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00014B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Myungji Kim, Minji Kim, Jinah Jang
This review introduces recent progress in immune-evasive islet replacement by integrating advances in cell-intrinsic immune engineering with bioengineering strategies that regulate the peri-graft physicochemical milieu.
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Targeting and self-assembling peptides mimic fibrinogen coagulation for alleviating hypofibrinogenemia

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01895A, Paper

Gui-Yuan Wang, Zhuo-Yue Li, Chao-Ran Li, Ya-Tao Wang, Pei-Pei Yang, Lei Wang, Hao Wang, Xu Cui, Litao Li
A fibrin-like peptide self-assembles from nanoparticles into nanofibers when targeting platelets and inducing the aggregation of platelets, which shows the recovered hemostatic functionality in the hypofibrinogenemia model.
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A click-crosslinked dopamine-functionalized hydrogel for therapeutic delivery of stem cell-derived extracellular vesicles

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01730K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Joshua S. Copus, Ji Hoon Park, Anthony Atala, Sang Jin Lee
A click-crosslinked dopamine-functionalized hyaluronic acid hydrogel system (Dopa-HA) provides sustained and localized delivery of bioactive molecules, such as extracellular vesicles (EVs), for in situ tissue regeneration.
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Supramolecular RNAi with multifunctional siRNA nanostructures

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01877C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Michael Shaikhet, Joshua O'Grady, Filiz K. Collak, Matthew Reynolds, Anatoli Ianoul, William G. Willmore, Bruce C. McKay, David Sabatino
Multifunctional siRNA nanostructures with supramolecular and photophysical properties exhibit significant intracellular anti-cancer activity, demonstrating their potential for cell biology applications.
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Engineering Metal-Ions-Doped Prussian Blue Nanoparticles: From Rational Synthesis to Cancer Theranostics

Biomater. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6BM00079G, Minireview

Kexin Zhang, Jingbo Dong, Mengdan Chen, Tianqing Zhang, Xuejiao Song, Qiufang Gong, Chao Liang
Malignant tumors remain a persistent global challenge in public health, with conventional treatment modalities such as surgery, chemotherapy, and radiotherapy suffering from inherent limitations including high recurrence rates, systemic toxicity,...
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Multifunctional Ti metal with magnesium and cerium co-incorporation: a bioactive surface modification approach for improved in vitro and in vivo performances

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00083E, Paper

Ann Mary Mathew, Sreya PV, Kalimuthu Vignesh, Chandran Manimegalai Swathi, Balamuthu Kadalmani, Deepak K. Pattanayak
An alkali-mediated ion exchange process where Mg and Ce ions get incorporated into the titanate nanonetwork on titanium. This functionalized surface improves antibacterial activity, cytocompatibility, and osseointegration for biomedical applications.
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Multiscale design strategies for high-performance hemostatic bioadhesives

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00259E, Review Article

Ruilin Shang, Lisha Yu, Zhengwei Mao
This review presents a multiscale framework for hemostatic bioadhesives, integrating macroscopic mechanics, micro/nanoscale structural reinforcement, and sub-nanometer interfacial bonding, and provides a blueprint for next-generation bioadhesives.
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Bridging the gap between visualization and reality: integrating degradation and metabolism data to elucidate recombinant collagen behavior

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00099A, Paper

Can Huang, Zhihui Li, Shuang Wu, Peiliang Shi, Zhengzhong Wu, Jie Li, Xiaoju Fan, Yuanxin Zhai, Hao Le, Huimin Wang, Xinhui Wang, Huilin Sun, Ziqing Zhu, Jinyu Lv, Longyang Wu, Yujiang Fan, Jianping Gao, Yun Chu, Tun Yuan
Current methodologies face limitations in elucidating the in vivo behavior of biodegradable protein-based biomaterials, particularly crosslinked recombinant collagen materials.
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Engineering nanosensitizers into hierarchical modulators for sonodynamic antibacterial therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00102E, Review Article

Min Sun, Dan Cheng, Yuchao Gu, Hao Hu
This review introduces a function-oriented hierarchical framework for designing heterojunction-based sonodynamic therapy nanoplatforms across three synergistic levels to enhance antibacterial performance.
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Recent advances in oral adhesives: fabrication, properties, and applications

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01890K, Review Article

Ying Qi, Chunyan Cui, Wenguang Liu
This article systematically reviews current oral tissue adhesive dosage forms, covering their design strategies, adhesion mechanisms, and performance evaluation, while also outlining future directions such as clinical translation.
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Hydrogel-based wearable and implantable biosensors in health monitoring

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01789K, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yutong Wang, Yihan Gao, Lingfeng Tang, Yuanyuan Guo, Baoning Sha, Yuanwen Jiang
Hydrogel-based wearable and implantable biosensors have established themselves as a paradigm-shifting platform for continuous health monitoring.
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Rational design of lipid and lipid-like structures for non-liver-targeted mRNA therapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01344E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yingwei Tang, Di Li, Yalin Zhu, Hongwei Duan, Anshun Zhao
The application of mRNA therapies has witnessed significant advancement since the outbreak of COVID-19.
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A biodegradable polymeric nanoparticle vaccine for combating Acinetobacter baumannii infection

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00143B, Paper

Yiming Lu, Yan Xu, Vladimir I. Potkin, Leijiao Li, Hanchen Zhang, Wenliang Li, Haihua Xiao
The developed NP-VAC is safe and highly immunogenic, providing full protection against A. baumannii and a strategy against bacterial infections.
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Bioactive chitosan scaffolds reinforced with hydroxyapatite and nickel tungstate for bone tissue engineering

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00120C, Paper

Giovanna A. Grasser, Diana Gabriela Nina Nina, Karolyne dos Santos Jorge Sousa, Mirian Bonifácio, Renata Neves Granito, Ailton José Moreira, Ana Claudia Muniz Rennó, Elson Longo, Marcelo Assis
Chitosan/hydroxyapatite scaffolds with NiWO₄ nanoparticles showed improved structure, controlled ion release, antimicrobial activity, and enhanced osteogenic response at low content, while higher concentrations induced cytotoxic effects.
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Electronic health record mining reveals effects of patient immune status on clinical outcomes of biomaterial implantation following skeletal muscle damage

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01334H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sonakshi Sharma, Isabella Horton, Aditya Josyula, Kaitlyn Sadtler
Evaluating electronic health records from patients with autoimmune conditions or immunodeficiencies that received biomaterial implants generated potential increased risks for graft complications following procedures.
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Macrophage phenotype modulation via 2-hydroxypropyltrimethyl ammonium chloride chitosan: a novel strategy for managing allergic rhinitis

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00169F, Paper

Yi Peng, Cuida Meng, Yu Liu, Kejia Li, Meng Zhu, Xiaoyan Ju, Ye Tian, Dongdong Zhu, Zhongwei Niu
This study demonstrates that HACC is a promising candidate for regulating immune responses and mitigating allergic airway inflammation.
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ROS-responsive mPEG-PCL nanoparticles for co-delivery of paclitaxel prodrug and R848 in synergistic chemo-immunotherapy

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01811K, Paper

Qi Zhang, Luyao Wang, Zhaofan Yang, Hao Meng, Shixian Lv, Linlin Liu
ROS-responsive mPEG-PCL co-delivers PTX-PBE and R848 for immune synergy.
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Antibacterial agent conjugated sponges to increase hydrophilicity for enhancing hemostasis and infected wound healing

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D5BM01892G, Paper

Qiusheng Wang, Yunpeng Wang, Ziyun He, Yun Bai, Bin He
Our study developed a degradable polyurethane sponge (PUF@PHMB) with rapid hemostasis, sustained antibiosis, and enhanced wound regeneration.
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Multiscale anisotropic scaffolds enable a biomimetic electro-mechanical myocardial platform for drug discovery and heart repair

Biomater. Sci., 2026, Advance Article
DOI: 10.1039/D6BM00103C, Paper

Jianyong Zou, Jiarong Zhang, Qiuyuan Zhao, Guangbing Luo, Xin Zhang, Shuhui Chen, Yanyan Li, Yutong He, Leyu Wang, Xiaozhong Qiu
Engineered cardiac microtissues on multiscale anisotropic scaffolds enhance contraction, enable high-sensitivity drug response, and improve cardiac function post-MI.
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