RSC - Chem. Soc. Rev. latest articles

Direct impure water electrolysis at industrial scale

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01553G, Review Article

Open Access

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Jichao Zhang, Jianrui Feng, Daojin Zhou, Hongtao Wang, Wei Liu, Longxiang Liu, Wei Zong, Jiexin Zhu, Ruwei Chen, Hongzhen He, Mingqiang Liu, Wei Zhang, Faze Chen, Ivan P. Parkin, Xiaoming Sun, Guanjie He
This review provides a comprehensive summary of direct impure water electrolysis, highlighting the impurity-induced interplay of each component for collaboratively achieving industrial-scale application.
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Catalytic valorization of polyolefins: from catalysts and processes to reactors

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01390A, Review Article

Cuncun Wu, Chaojie Guo, Xinquan Xu, Kun Liu, Lingyu Bai, Nan Yang, Donglong Fu, Jinlong Gong
This review describes progress in catalytic valorization of polyolefins across length scales, connecting active-site chemistry, process development and optimization, and reactor selection and design.
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Designing stable π-radicals

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D4CS01126K, Tutorial Review

Open Access

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Arthur Houplin, Cheng-Hao Liu, Dmytro F. Perepichka
A historically informed guide to designing stable π-conjugated radicals is presented and their unique optoelectronic and magnetic properties are discussed.
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Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00617A, Review Article

Guilherme F. S. Fernandes, Seong-Heun Kim, Jean L. Dos Santos, Yuhang Wang, Christelle Soudy, Joanna Redmond, Daniele Castagnolo, Matthew Todd
We outline major bottlenecks and the clinical pipeline landscape, then present a structure-led analysis of synthetic small-molecule validated leads supported by in vivo data.
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Selective carbon–carbon bond cleavage involving alkene moieties

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01173F, Tutorial Review

Qixue Qin, Xiao-De An, Shuanghong Hao, Ning Jiao
This review has systematically surveyed the recent groundbreaking advances of the cleavage of robust σ-bonds adjacent to the alkene and the novel transformations such as nitrogenation and oxygenation reactions through CC double bond cleavage.
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Circularly polarized luminescence: an easy path from molecules to supramolecular systems and beyond

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00339G, Tutorial Review

Francesco Bertocchi, Davide Giavazzi, Shahana Nizar, D. K. Andrea Phan Huu, Lorenzo Savi, Francesca Terenziani, Cristina Sissa, Anna Painelli
This tutorial introduces circularly polarized luminescence of organic materials. It covers basic concepts, experimental determination, an overview of models, and the challenges of circularly polarized electroluminescence.
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Biological conversion of CO2 for bioproduction: beyond natural limitations

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01228G, Tutorial Review

Chunlei Zhao, Pan Zhu, Tiantian Chai, Jian Zhang, Xiulai Chen
This review summarizes advances in constructing synthetic CO₂ bioconversion systems to facilitate the conversion of CO₂ into value-added products by coupling CO₂ fixation modules with energy supply modules.
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Gold-based multimetallic catalysis

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00282F, Review Article

Arup Jyoti Das, Shivhar B. Ambegave, Aliya V. Jinilkumar, Kumarjit Sen, Nitin T. Patil
This review provides an up-to-date overview of developments in gold-based multimetallic catalysis, with particular emphasis on mechanistic aspects and highlights its potential for enabling new organic transformations.
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Triad of electrocatalytic strategies for polymer monomer synthesis

Chem. Soc. Rev., 2026, 55,6898-6926
DOI: 10.1039/D6CS00501B, Review Article

AJing Song, Yuanyuan Ma, Ziyang Wu, Min Kuang, Yuqin Zou, Jianping Yang
Electrocatalysis provides a sustainable route for polymer monomer synthesis from renewable feedstocks, and this review summarizes three representative strategies together with system-level considerations for scalable implementation.
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AI for battery-accelerated discovery of high-voltage electrolytes for advanced lithium batteries

Chem. Soc. Rev., 2026, 55,6625-6674
DOI: 10.1039/D4CS01250J, Review Article

Yu Zhan, Nan Chen, Li Li, Feng Wu, Renjie Chen
This review provides a comprehensive overview of the recent advances in the artificial intelligence–assisted design of high-voltage electrolytes, introduces the AI4B paradigm, and outlines the key directions for future research.
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Clinical translation and landscape of stimuli-responsive nanomedicines and microscale therapeutics

Chem. Soc. Rev., 2026, 55,6704-6738
DOI: 10.1039/D6CS00165C, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dmytro Kobzev, Olesia Kulyk, Roman A. Barmin, Anatoliy Tatarets, Roger M. Pallares, Fabian Kiessling, Twan Lammers, Quim Peña
We present a large-scale scientometric (pre-)clinical landscape analysis of stimuli-responsive therapeutics, highlighting the impact of nano-/micro-scale material platforms, and mapping translational barriers and strategies to overcome them.
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Photografting: a method for surface modification

Chem. Soc. Rev., 2026, 55,6858-6897
DOI: 10.1039/D6CS00331A, Review Article

Jean Pinson
Photografting enables the covalent modification of a wide variety of surfaces—including polymers, metals, carbons, and oxides—through irradiation of a deposited solution.
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Indium-based colloidal quantum dots for photocatalytic applications: advances and perspectives

Chem. Soc. Rev., 2026, 55,6814-6857
DOI: 10.1039/D6CS00515B, Review Article

Yixiao Huang, Jianguo Tang, Zhengquan Li, Dongling Ma, Jin Wang, Zhonglin Du
Eco-friendly indium-based quantum dots (InQDs) provide a new direction for designing novel sustainable heavy-metal-free photocatalysts.
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Intelligent catalysis: on-demand dynamic self-optimization via responsive feedback

Chem. Soc. Rev., 2026, 55,6571-6590
DOI: 10.1039/D5CS01292A, Tutorial Review

Linbo Jiang, Shichun Mu
This review investigates intelligent self-optimization effects, responsive mechanisms and multimodal intelligent catalysis, associated challenges and solutions, aiming to promote on-demand applications in complex multi-scenario environments.
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Strong exciton coupling: a practical toolbox for computing interaction energies, wavefunctions, and optical spectra

Chem. Soc. Rev., 2026, 55,6462-6499
DOI: 10.1039/D6CS00157B, Tutorial Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Rasmus Ringström, S. Rasoul Hashemi, Yuanxin Liang, Nicholas J. Hestand, Karl Börjesson
This review presents a practical toolbox for modelling exciton coupling in molecular aggregates, from Coulombic interactions and vibronic coupling to charge-transfer effects.
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An overview of reaction outcome prediction with physics-based and data-driven methods

Chem. Soc. Rev., 2026, 55,6768-6813
DOI: 10.1039/D6CS00079G, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Joonyoung F. Joung, Nicholas Casetti, Priyanka Raghavan, Connor W. Coley
Reaction outcome prediction can be formulated in multiple ways, spanning physics-based exploration of reaction pathways and data-driven prediction of product likelihoods.
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Switchable and biodegradable nanostructures for safe and precise tumor diagnostics

Chem. Soc. Rev., 2026, 55,6500-6570
DOI: 10.1039/D5CS00925A, Tutorial Review

Rebeka Rita Reszegi, Wenyao Zhen, Xiaoyuan Chen, Jingjing Zhang
This tutorial review outlines design principles for switchable and biodegradable nanostructures in cancer imaging, with emphasis on activation, stability, and clearance.
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Pore engineering in crystalline frameworks: from MOF “chemistry” to HOF “mechanics” for advanced drug delivery

Chem. Soc. Rev., 2026, 55,6675-6703
DOI: 10.1039/D6CS00465B, Review Article

Ke Jiang, Zhining Yuan, Ling Zhang, Banglin Chen, Guodong Qian
Pore engineering bridges MOF chemistry and HOF mechanics, enabling chemically and mechanically gated crystalline frameworks for precision drug delivery.
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Emerging porous materials for cell encapsulation

Chem. Soc. Rev., 2026, 55,6591-6624
DOI: 10.1039/D4CS00071D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Francesco Carraro, Miriam de J. Velásquez-Hernández, Anita Emmerstorfer-Augustin, Daniel Kracher, Qilu Wu, Robert Kourist, Lien-Yang Chou, Ju Ge, Fa-Kuen Shieh, Christian Doonan, Paolo Falcaro
This review summarizes recent advances in cells@MOFs, cells@COFs, and cells@HOFs: synthesis strategies, cell–framework interactions, viability assessment, and advanced biotechnological applications.
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Nano-structuring hydrogen-bonded organic frameworks: strategies, composites, and functional applications

Chem. Soc. Rev., 2026, 55,6739-6767
DOI: 10.1039/D5CS01279A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Qiang Zhu, Antonio Fernandez
This review provides an overview of hydrogen-bonded organic frameworks nanomaterials, focusing on classification, fabrication strategies, diverse applications, and future perspectives in this evolving field.
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Advanced fluorine chemistry in >4.2 V high-voltage lithium metal batteries

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00326E, Review Article

Yu Sun, Junjie Du, Daxian Zuo, Tao Yu, Shaohua Guo, Haoshen Zhou
This review systematically summarizes fluorine chemistry in high-voltage lithium metal batteries, highlighting its key roles and prospects to provide a comprehensive guideline for engineering safe, durable, and high-energy-density batteries.
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Understanding the chemistry of re-emerging proton batteries

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00746A, Review Article

Usman Ghani, Farman Ullah, Junying Zhang, Bingqing Ye, Shitong Wang, Xingke Cai, Jun Lu
From fundamental mechanisms to practical challenges, this review highlights how engineered proton channels and water frameworks pave the way for next-generation, wide-temperature-range proton batteries.
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Rational design of high-loading electrocatalytic electrodes: from static multiscale integration to dynamic intelligent systems

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01399B, Review Article

Zijing Suo, Yuyao Sun, Jianping Lai, Lei Wang
Paradigm shifts and pathways for high-loading electrocatalytic electrodes from static design to dynamic intelligent systems.
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Outstanding Reviewers for Chemical Society Reviews in 2025

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS90053D, Editorial

We would like to take this opportunity to highlight the Outstanding Reviewers for Chemical Society Reviews in 2025, as selected by the editorial team for their significant contribution to the journal.
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Radical-promoted “unstrained” C–C and C–N bond cleavage: a blueprint for deconstructive skeletal editing

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01539A, Tutorial Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

José Justicia, Sara P. Morcillo
Control over radical generation governs β-scission and enables selective skeletal editing.
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Functional group translocation: moving functionalities without changing molecular scaffolds

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00145A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Eito Moriya, Junichiro Yamaguchi
Functional group translocation directly relocates functional groups without changing the molecular scaffold, enabling access to positional isomers. This review outlines the concept and advances in aromatic and aliphatic systems.
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Recent advances in ambipolar organic light-emitting transistors: materials and devices

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00036C, Review Article

Shaoqing Guan, Qingbin Li, Can Gao, Huanli Dong
This review focuses on ambipolar organic light-emitting transistors (OLETs), emphasizing the rational design and synthesis of ambipolar high-mobility emissive semiconductors as well as device structure optimization.
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Engineering coordination bonds for bioinspired responsive polymers

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01074H, Review Article

Muqing Si, Weihao Feng, Tao Chen, Wei Lu
This review highlights how coordination-crosslinked polymer networks translate dynamic metal–ligand coordination bonds and their synergy with other dynamic bonds into responsive soft materials.
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Self-assembly for cuproptosis-based cancer therapy and imaging

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01136A, Review Article

Qiyue Wang, Hui Du, Xinting Li, Xinke Hu, Nayeon Kang, Heemin Kang, Fangyuan Li, Daishun Ling
This review highlights recent advances in dynamic self-assembled cuproptosis nanosystems that leverage copper coordination chemistry and stimuli-responsive structural reconfiguration for spatiotemporally controlled cancer therapy and imaging.
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Multiscale cathode design for high-temperature proton exchange membrane fuel cells

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00242K, Review Article

Zhuo-Qi Shi, Liang Ding, Ze-Cheng Yao, Tang Tang, Rui Cao, Jin-Song Hu
This review highlights the multiscale cathode design for high-temperature proton exchange membrane fuel cells, bridging the gap from atomic-level catalyst design and interfacial engineering to device-level catalyst layer optimization.
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Framework materials for nuclear waste treatment

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00154H, Review Article

Mengjie Hao, Xiaolu Liu, Yinghui Xie, Hanzhi Chen, He Gu, Chuanlei Luo, Muliang Xiao, Xinyue Zhang, Jiaqi Li, Xinyi Yang, Juyao Zhang, Hui Yang, Fuyou Fan, Juncheng Liang, Xiangke Wang
This review comprehensively summarizes and discusses recent advances in framework materials for nuclear waste treatment, covering key aspects of materials design, synthesis, performance, and fundamental structure–property–function relationships.
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Zinc chalcogenide semiconductor nanocrystals: from synthesis to optoelectronic applications

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01317H, Review Article

Zhaoze Shen, Qian Wang, Kequan Cao, Xuerong Song, Binbin Yu, Jiajia Ning, Fei Huang, Jianjun Tian
This review elucidates advances in eco-friendly Zn chalcogenide nanocrystals, detailing growth mechanisms, controllable synthesis, and optoelectronic applications, and proposes remaining challenges alongside future perspectives.
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Inverted perovskite solar cells: from fundamentals to scalable commercialization

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS01554E, Review Article

Biyun Ren, He Dong, Junjie Sun, Chenxin Ran, Yingdong Xia, Lingfeng Chao, Yonghua Chen, Wei Huang
This review highlights recent advances in highly efficient and stable inverted PSCs and discusses key directions for achieving large-area fabrication and enhanced stability to accelerate commercialization.
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How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution

Chem. Soc. Rev., 2026, 55,6417-6452
DOI: 10.1039/D5CS01387A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Douglas B. Kell, Ivayla Roberts
Rugged protein fitness landscapes can be learned from sparse sequence–activity data. Machine learning plus extreme-value theory can guide directed evolution toward rarer, higher-activity variants.
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Single crystal covalent organic frameworks

Chem. Soc. Rev., 2026, 55,6344-6416
DOI: 10.1039/D5CS00526D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yongzhi Chen, Zhihao Zhang, Donglin Jiang
This review maps strategies to achieve single crystal COFs, outlining methodological developments toward precise crystallization control and linking structure integrity with enhanced properties and advanced functional applications.
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Chemical insights on covalent organic frameworks for ferroptosis and pyroptosis in cancer

Chem. Soc. Rev., 2026, 55,6058-6074
DOI: 10.1039/D5CS01295C, Tutorial Review

Eunji Kim, Min-Goo Lee, Yoonji Heo, Sumin Kim, Jiwoo Seo, Sungwook Jung, Jong Seung Kim, Min Kim
Covalent organic frameworks (COFs), with their customizable structures and properties, can be employed as comprehensive platforms to induce ferroptosis and pyroptosis.
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Circularly polarized luminescence in chiral hybrid metal halides

Chem. Soc. Rev., 2026, 55,6018-6036
DOI: 10.1039/D6CS00132G, Tutorial Review

Yi Wei, Huimin Kang, Yuxuan Wang, Yulian Liu, Zewei Quan
Chiral hybrid metal halides are promising circularly polarized luminescence materials with high emission efficiency and large dissymmetry factor. This review summarizes CPL generation, amplification strategies, and emerging applications.
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Surface and interface atomic engineering of ultrathin 2D inorganic materials for small molecule photocatalysis

Chem. Soc. Rev., 2026, 55,6037-6057
DOI: 10.1039/D6CS00318D, Tutorial Review

Juncheng Zhu, Zijia Lin, Yang Wu, Yongfu Sun, Yi Xie
This review categorizes modification strategies into surface and interface atomic engineering and systematically elucidates their impacts on electronic structures and photocatalytic performances.
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Tissue-bioelectronics interfaces

Chem. Soc. Rev., 2026, 55,6307-6343
DOI: 10.1039/D5CS01422K, Review Article

Jiahong Li, Jin Qu, Wei Gao
A mechanism-driven framework for tissue–bioelectronics interfaces, integrating interfacial mechanisms, materials, structural design and fabrication to enable stable, conformal bioelectronic systems for continuous monitoring and therapy.
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Optical probes for bioimaging of tumor-infiltrating immune cells and their applications in cancer immunotherapy

Chem. Soc. Rev., 2026, 55,6075-6116
DOI: 10.1039/D5CS01412C, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xinglong Chen, Cong Hu, Heejeong Kim, Lemeng Zhang, Zhipengjun Zhang, Hongwen Liu, Juyoung Yoon
Optical probes and their applications in biomedicine.
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Stimuli-responsive nanoplatforms for central nervous system disorders: integrating delivery, modulation, and imaging

Chem. Soc. Rev., 2026, 55,6257-6306
DOI: 10.1039/D5CS01323B, Review Article

Yihan Chen, Yuanqing Ding, Han Lin, Jianlin Shi
Stimuli-responsive nanoplatforms integrate endogenous cues and external fields to enable BBB-crossing delivery, neuromodulation and imaging-guided therapy, advancing adaptive treatment for CNS disorders.
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Recent advances in photochemical rearrangements involving diradicals

Chem. Soc. Rev., 2026, 55,6221-6256
DOI: 10.1039/D6CS00068A, Review Article

Jun-Jie Chen, Shu-Sheng Chen, Qiu-Zhu Wang, Huan-Ming Huang
This review highlights recent advances in photochemical rearrangements involving diradical intermediates, including ring expansion, ring contraction, ring construction, applications in natural products and materials synthesis.
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Laser-induced polymer dynamics and applications

Chem. Soc. Rev., 2026, 55,6117-6154
DOI: 10.1039/D5CS00047E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Daeyeon Won, Jiyong Ahn, Jooyeun Chong, Ahyoung Cho, Taehyun Kim, Seok Hwan Choi, Deog-Gyu Seo, Jiheong Kang, Seung Hwan Ko
In this review, we introduce the latest discoveries in the interaction of lasers with various functional polymers, discussing energy delivery mechanisms and their influence on structure modifications and property changes.
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The importance of nano–bio interfacial design in the sensing performance of nanoparticle-based affinity biosensors

Chem. Soc. Rev., 2026, 55,6182-6220
DOI: 10.1039/D5CS00823A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xueqian Chen, Xuejie Li, Richard D. Tilley, J. Justin Gooding
This review covers interfacial design of nanoparticle modification, including the impact of the biomolecule orientation and coverage, the composition of surface modifying layers and spatial distribution of biomolecules on nanoparticles.
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The sustainability of the Morita–Baylis–Hillman reaction

Chem. Soc. Rev., 2026, 55,6155-6181
DOI: 10.1039/D5CS01408E, Review Article

Thaynan A. B. Chagas, Manoel T. Rodrigues, Fábio S. Fernandes, Luna S. dos Santos, Cíntia D. F. Milagre, Wanda P. Almeida, Fernando Coelho
The MBH reaction is a chemical transformation that offers several sustainability advantages and enables the synthesis of small, polyfunctionalised products with high synthetic versatility. In this review, we discuss some of these sustainable aspects.
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Unravelling hetero-intermediate interactions in electrocatalytic hydrogenation: a framework for mechanistic understanding and performance regulation

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D6CS00363J, Tutorial Review

Hanle Liu, Shunhan Jia, Ruhan Wang, Limin Wu, Xiaofu Sun, Buxing Han
Three interaction models are introduced to help analyse intermediate behaviour and reaction pathways at key reaction steps.
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Recent advances in cell-surface glycan engineering and its biological applications

Chem. Soc. Rev., 2026, Advance Article
DOI: 10.1039/D5CS00007F, Review Article

Chang-Hee Lee, Joo Hee Choi, Eunseo Lee, Na Ryeong Kim, Ji Young Hyun, Hak Joong Kim, Injae Shin
We highlight recent advances in cell-surface glycan engineering and its applications for studying glycan-mediated biological events and developing therapeutics.
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