RSC - Food Funct. latest articles

Fermented goat milk powder promotes intestinal development and enhances splenic antioxidant function in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00370B, Paper

Liaoyu Fan, Kela Sha, Hui Zhang, Guodong Li, Liyan Ge, Jintao Li, Yong Ning, Ge Zhang, Huaiping Shi
Fermented goat milk powder (FGMP) improves intestinal structure and enhances spleen antioxidant capacity by modulating gut microbiota and metabolites.
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Stevioside extends the healthspan and improves Alzheimer's disease and increases oxidative stress resistance via the mitochondrial unfolded protein response

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00251J, Paper

Xiaocong Li, Yi Xiao, Fang Liu
Stevioside extends the healthspan and improves Alzheimer's disease and increases oxidative stress resistance by ATFS-1-mediated UPR^mt.
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Fucoxanthin ameliorates experimental autoimmune encephalomyelitis by inhibiting microglial NLRP3 inflammasome

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04970A, Paper

Xiaoqian Dong, Linlin Zhang, Yuxin He, Jiayu Zhang, Huichan Zhou, Yingxia Zhang, Junjian Li, Rong Wang, Da-Qi Zhang
Fucoxanthin, an algal compound, attenuates EAE by inhibiting microglial M1 polarization and NLRP3-mediated pyroptosis, suggesting its potential as a therapy for multiple sclerosis.
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Association of ultra-processed foods (UPFs) with hypertriglyceridemic waist (HTGW) phenotype, oxidative stress, and inflammation in Iranian adults: A cross-sectional study

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D5FO05626H, Paper

Reyhane Rostamian, Mahdi Moabedi, Donya Poursalehi, Zahra Moradmand, Farnaz Shahdadian, Parisa Rouhani, Parvane Saneei
Background: Ultra-processed foods consumption has been increasing globally as well as in the Iranian population, coinciding with rising rates of metabolic diseases. Concurrently, the hypertriglyceridemic waist (HTGW) phenotype has been...
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Probiotic Lactobacillus kefiranofaciens K6 attenuates physiological and behavioral alterations and modulates the gut microbiota in a mouse model of overtraining syndrome

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00574H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yen-Po Chen, Ming-Han Gao, Wen-Chi Wei, Wen-Ching Huang
Excessive training induced metabolic, inflammatory, behavioral, and gut microbiota alterations in an OTS-like mouse model. Lactobacillus kefiranofaciens K6 supplementation was associated with attenuation of these changes.
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Oleacein prevents metabolic dysfunction-associated hepatic steatosis and dyslipidaemia in ApoE-KO mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05134G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Beatriz Ormonde, Vânia Costa, Pedro Vieira, André Alves, Sofia Viana, Flávio Reis, Fátima Paiva-Martins
Oleacein improves blood lipid profile and reduces hepatic lipid accumulation in steatotic ApoE-KO mice.
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Poria cocos polysaccharide alleviates multidrug-resistant Klebsiella pneumoniae-induced acute lung injury by modulating the gut–lung axis via gut microbiota remodeling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01450J, Paper

Yifei Xiang, Shuxin Zhu, Renhe Wang, Jingsheng Huang, Han Li, Dejia Dai, Yunmei Yang, Hao Hu, Yingyi Wei, Tingjun Hu, Jiakang He, Zhengmin Liang
Poria cocos polysaccharide relieves MDR-KP-induced acute lung injury through regulation of the gut microbiota and barrier, an effect that is weakened upon gut microbiota depletion.
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Protein hydrolysates and xanthine oxidase inhibitory peptides from sunflower capitulum exert antihyperuricemic effects: a comprehensive study based on serum metabolomics and gut microbiota analysis

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01257D, Paper

Xiaoyu Liu, Liyan Ma, Zhuoyan Fan, Jiaxing Fan, Wanlong Lu, Lei Zhang, Jingming Li
Comparative evaluation of sunflower capitulum protein hydrolysate and the xanthine oxidase inhibitory peptide LGDF reveals distinct antihyperuricemic effects through purine metabolism, serum metabolomics, and gut microbiota modulation.
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Metabolomic insights reveal bioactive enhancement in fermented oat-based beverages via Lactobacillus plantarum

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00493H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Aly Castillo, Matteo Emilio Federico Capietti, Cristina Megias, Javier Olleros, Fabio Días, Bernardo Ordás, Gerardo Alvarez-Rivera, Marta Lores
This study evaluates the impact of thermal processing and fermentation with Lactobacillus plantarum on the bioactive composition and metabolic profile modulation of an oat-based (Avena sativa) beverage. A base beverage...
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Hypouricemic and renal protective effects of the Chinese functional tea Ligustrum robustum on hyperuricemic mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00994H, Paper

Xiao-Long Tian, Zuo Zheng, Qian Wang, Jun-Yan Ran, Ying-Cai Zhang, Dong-Mei Zhou, Xin Lang, Li Jiang, Xue-Long Yan, Xiang Fang, Shang-Gao Liao
Ligustrum robustum showed hypouricemic and renoprotective effects by reducing uric acid production, promoting excretion, regulating transport, and suppressing TNF/NF-κB inflammation.
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Immunoprogramming by maternal fibre and polyphenol intake enhances humoral systemic and mucosal immunity in adult offspring

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04563K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sergi Casanova-Crespo, Daniela Ceballos-Sánchez, Maria José Rodríguez-Lagunas, Malén Massot-Cladera, Margarida Castell, Francisco José Pérez-Cano
Maternal diet is an element of the exposome that could shape the immune development in mothers’ offspring.
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Oleic and omega-3 fatty acids buffer neuroinflammation in a scopolamine model with Alzheimer's-like features via target-level interactions

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00279J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Marlua Albertuni, Maria Torrecillas-Lopez, Teresa Gonzalez-de la Rosa, Luna Barrera-Chamorro, Elvira Marquez-Paradas, Jose L. del Rio-Vazquez, Maria D. Navarro-Hortal, Carmen M. Claro-Cala, Sergio Montserrat-de la Paz
Diet quality, beyond total fat, may shape brain immune tone in Alzheimer's-relevant contexts.
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Prebiotic activity and antidiabetic potential of Ginkgo isomalto-oligosaccharides

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00811A, Paper

Yu Chen, Xinyi Zhang, Tingting Li, Caie Wu, Gongjian Fan, Xiaojing Li, Dandan Zhou, Yang Song
This study compares Ginkgo isomalto-oligosaccharides (G-IMO) with corn-derived IMO (C-IMO) to evaluate their prebiotic and antidiabetic potential.
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Causal associations of dietary habits and blood metabolites with Parkinson's disease risk

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO02160J, Paper

Jikuang Zhao, Liangzhe Wei, Mingyue Zhao, Hangyu Sheng, Xu Yan, Sheng Nie, Yi Huang
Parkinson's disease (PD) is a neurodegenerative disorder with unclear etiology, though dietary factors and metabolic alterations are implicated.
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Effects of perilla oil on platelet and inflammatory responses in healthy smokers: a randomized, double-blind, placebo-controlled, parallel trial

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01112H, Paper

Sehee Lee, Kyeong Jin Kim, Min Ju Park, Soo-yeon Park, Young-Jun Kim, Hyounggyoon Yoo, Ji Yeon Kim
8-week ALA-rich perilla oil supplementation increases blood omega-3 levels and modulates platelet and inflammatory responses in healthy smokers.
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Ultrasonic modulation of amyloid fibrillization in Antarctic krill protein for enhanced iron delivery

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00210B, Paper

Jinhui Hu, Xueqing He, Yihan Huang, Songyi Lin, Na Sun
Ultrasound regulates the structure of amyloid fibrils from krill protein. This greatly enhances iron binding and enables sustained Fe²⁺ release.
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Ameliorative effect of docosahexaenoic acid-acylated astaxanthin ester on diabetic nephropathy: association with the trehalose/HSP90AA1 and colon–kidney axis

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00946H, Paper

Jialin Yin, Xu Deng, Yanqi Hu, Fang Zheng, Huali Meng, Xiaoli Huang, Kebo Wang, Xiaodong Zhao, Lei Sun, Hao Wu
As a severe microvascular complication of diabetes, diabetic nephropathy (DN) lacks safe and effective preventive interventional strategies. Previous enterostomy-based colonic perfusion studies have shown that colon-targeted DHA delivery has superior...
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Pyrroloquinoline quinone and imidazopyrroloquinoline intake diminish mortality risk during midlife and improve muscular dysfunctions with age in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00788K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Keiko Odera, Yuka Tanaka, Kazuto Ikemoto, Masanori Tamakoshi, Ryoya Takahashi
PQQ and IPQ supplementation, whether initiated early or in middle-age, effectively ameliorates age-related alterations.
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Fungal exosome-like nanoparticles ameliorate exercise capacity and metabolic health in sleep-deprived mice by modulating the gut microbiota

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05659D, Paper

Haotian Zhao, Wenlong Sun, Guoliang Yin, Fengming Zhang, Hongkang Zhu, Chang Liu, Naiyan Lu
Fungal exosome-like nanoparticles (FELNs) derived from black truffles represent an emerging class of bioactive nanovesicles with potential therapeutic applications, yet their effects on sleep deprivation (SD)-induced impairments remain unexplored.
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Barley extrudates modulate the gut microbiome–metabolome axis in vitro through β-glucan fermentation and polyphenol biotransformation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00601A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mariona Martínez-Subirá, María Engracia Cortijo Alfonso, Iván Friero, Alba Macià, Ramona N. Pena, Natalia Molinero, M. Victoria Moreno-Arribas, Laura Rubió-Piqué, Marian Moralejo
Extrusion-tailored barley matrices modulate the gut microbiome–metabolome axis, enhancing butyrate and microbial phenolic metabolites.
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Noni (Morinda citrifolia L.) fruit juice induces ferroptosis in gastric cancer cells via the Nrf2/HO-1–GPX4 axis

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO03232F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Zhihao Xie, Hejiao Li, Weifeng Lu, Lijie Liu, Dianxiao Liao, Chunmeng Mai, Xian Fu, Minni Zhang, Xiuying Tian, Xinbao Hao, Lu Xu
Investigating the inhibition of gastric cancer growth and the induction of lipid peroxidation triggering ferroptosis by noni (Morinda citrifolia L.) juice highlights the potential of functional foods in cancer intervention.
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Akkermansia muciniphila ameliorates acute liver injury aggravated by MASLD-associated dysbiosis via daidzein/PPAR-α/NF-κB signaling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01338D, Paper

Ziyuan Zhou, Xiaxia Pan, Jiali Ni, Zhuoqi Lou, Yangfan Shen, Shiman Jiang, Xiangmin Dong, Fengjiao Wang, Yanfei Chen, Lanjuan Li
MASLD-associated gut dysbiosis disrupts daidzein/PPAR-α/NF-κB signaling via gut–liver axis, heightening ALI risk. Gut dysbiosis may be a predictor for ALI in MASLD patients, and microecological or dietary interventions are preventive strategies.
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Correction: Multi-omics reveals gut microbiome- and metabolome-specific responses to sugar alcohols

Food Funct., 2026, 17,4298-4298
DOI: 10.1039/D6FO90033J, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mengling Liu, Zhandong Yang, Boyu Liu, Hongbo Cheng, Jiannan Qin, Pingjun Zhang, Tingfan Tang, Fei Peng, Jiguo Yang, Ping Wei, Huihui Su
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Theabrownin derived from Pu-erh tea enhances intestinal barrier integrity and microbiota balance via the ST6GalNAc6-STn-MUC2 axis in inflammation

Food Funct., 2026, 17,4287-4297
DOI: 10.1039/D5FO05118E, Paper

Keqin Xie, Yumei Qin, Lulu Li, Qing Zhu, Tong Ye, Wenzhu Wang, Jianzhong Han, Yanpei Gu
Ulcerative colitis (UC) involves chronic intestinal inflammation, epithelial barrier disruption, and microbial dysbiosis.
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Lithocarpus litseifolius leaf extract and its flavonoids alleviate hyperuricemia via TLR2/PI3K/NF-κB pathway inhibition and gut microbiota modulation

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05398F, Paper

Shaoyi Cai, Yuanyuan Chen, Tao Luo, Guangqiang Ma, Yu Zhong, Ailan Wu, Shuhong Peng, Chengdong Liao, Hua Zhang, Changhua Zhang, Lan Cao
Lithocarpus litseifolius (Hance) Chun (Lithocarpus polystachyus Rehd.) is a medicinal and edible plant.
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Milk exosomes attenuate OVA-induced food allergy by regulating the Th1/Th2 balance and remodeling the gut microbiota

Food Funct., 2026, 17,4262-4274
DOI: 10.1039/D6FO00469E, Paper

Siqi Fu, Chao Zhang, Yan Liu, Xin Ma, Ruofan Xie, Hongbing Chen, Xin Li
M-Exo was extracted by ultracentrifugation and a model of daily intervention of M-Exo in OVA allergic mice was established to study the immune regulatory effect of M-Exo on food allergy in mice.
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Plasma carotenoids and (poly)phenols in people living with an ileostomy: associations with dietary intake

Food Funct., 2026, 17,3972-3985
DOI: 10.1039/D6FO00497K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Niamh Magee, Brian Óg Murphy, Gema Pereira-Caro, Salud Caceres-Jimenez, Mary Slevin, Roger Lawther, Gloria O'Connor, James Davis, L. Kirsty Pourshahidi, Alan Crozier, Chris I. R. Gill
Individuals with an ileostomy (ileostomists) face unique physiological and dietary challenges that may impact on the bioavailability of phytochemicals, including carotenoids and (poly)phenols.
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The role of gut microbiota in shaping and modulating dietary preferences in neurological diseases: implications for microbiota-targeted interventions

Food Funct., 2026, 17,3871-3915
DOI: 10.1039/D5FO02826D, Review Article

Tingting Hou, Zhixing Peng, Yonglin Chen, Yanqing Feng, Xiaohui Hou, Yu-Heng Mao
The dietary preferences of patients with neurological disorders interact with the brain through different pathways of the gut-brain axis.
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Effect of Capsicum annuum leaf extract addition timing on yogurt bioactivity, digestibility, and cellular antioxidant defence

Food Funct., 2026, 17,4130-4152
DOI: 10.1039/D6FO00042H, Paper

Ajibola Nihmot Ibrahim, Ning Xu, Suxia Shen, Zhaotian Yang, Lin Zeng, Yan Zhang
The timing of Capsicum annuum leaf extract addition alters yogurt functionality: pre-fermentation addition boosts antioxidant stability and cellular antioxidant defence; post-fermentation addition improves protein digestibility and enzyme inhibition.
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Multi-omics reveals gut microbiome- and metabolome-specific responses to sugar alcohols

Food Funct., 2026, 17,4110-4129
DOI: 10.1039/D6FO00282J, Paper

Mengling Liu, Zhandong Yang, Boyu Liu, Hongbo Cheng, Jiannan Qin, Pingjun Zhang, Tingfan Tang, Fei Peng, Jiguo Yang, Ping Wei, Huihui Su
The impacts of sugar alcohols (SA) utilized as low-calorie sweeteners on the gut microbiome and metabolome remain undefined.
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Secoisolariciresinol diglucoside resolves systemic and skin inflammation in psoriatic mice by ameliorating the gut microbiome and modulating immune responses

Food Funct., 2026, 17,4185-4200
DOI: 10.1039/D5FO04965B, Paper

Bao-Juan Yuan, Yu-Hui Wang, Jin-Ru Lai, Liang Liu, Jia-Wei Zhang, Hong-Da Tian, Randal N. Johnston, Gui-Rong Liu, Shu-Lin Liu
The lignans (SDG and its metabolite ENL) have potent effects to resolve psoriatic inflammation and alleviate skin pathology by redressing the gut dysbiosis and modulating immune functions.
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Association of dietary calcium and its food sources with age-related macular degeneration in China: a population-based case-control study

Food Funct., 2026, 17,4066-4073
DOI: 10.1039/D5FO04327A, Paper

Hong Jiang, Xiaoyan Wang, Lina Wang, Yahui Fan, Zhaofang Li, Mei Ma, Sijiao Liu, Baoyu Li, Jia Shi, Chao Li, Le Ma, Juan Li, Wei Zhang
Higher dietary calcium was associated with a reduced risk of age-related macular degeneration in a Chinese population with relatively low intake. A similar inverse association was found for dairy-derived calcium, but not for vegetable or legume sources.
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Taurine mitigates bisphenol A-induced maternal–fetal oxidative stress and improves fetal weight by regulating Nrf2-Keap1 pathway, gut microbiota and bile acid metabolism

Food Funct., 2026, 17,4213-4230
DOI: 10.1039/D6FO00521G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lei Xu, Chenggang Yin, Yuyang Fan, Jiaqi Yang, Dongxu Ming, Yanpin Li, Wenjuan Sun, Xilong Li, Yu Pi
Taurine mitigates bisphenol A (BPA) exposure-induced disruption of the maternal–fetal environment, resulting in fetal growth restriction and tissue damage.
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Dietary (poly)phenols, the gut-brain axis, and menopause: a perspective on an overlooked biological crossroad

Food Funct., 2026, 17,3854-3870
DOI: 10.1039/D6FO00429F, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

María García-Nicolás, María Paula Jarrín-Orozco, María Romo-Vaquero, María Elena Martínez-Nortes, María Ángeles Ávila-Gálvez, Juan Carlos Espín
Polyphenols and gut-derived metabolites modulate SCFAs, indoles, TMA, and neuroactive pathways, thereby shaping gut-brain communication in postmenopausal women facing hormonal decline, inflammation, metabolic changes, and polypharmacy.
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Polyphenols in gut barrier function across diverse natural sources: mechanisms and comparative insights in berry and seaweed-derived compounds

Food Funct., 2026, 17,3842-3853
DOI: 10.1039/D5FO05231A, Review Article

Scott D. Smid
Dietary polyphenols protect human intestinal barrier function via multiple pathways. Via diverse natural sources: from berry flavonoids to seaweed phlorotannins.
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Effects of a phenolic-rich grape pomace extract on intestinal barrier, gut microbiota, and adipose tissue in high-fat diet–fed mice

Food Funct., 2026, 17,4074-4089
DOI: 10.1039/D5FO04667J, Paper

Diahann J. Perdicaro, Victoria Muscia Saez, Valeria V. Costantino, Eleonora Cremonini, Valeria E. Cacciamani, Hatice Duman, Sercan Karav, Steven A. Frese, Marcela A. Vazquez Prieto
Obesity disrupts intestinal barrier integrity and gut microbiota, contributing to endotoxemia and adipose tissue dysfunction. Grape pomace extract attenuates these alterations.
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Citrus unshiu fermented vinegar and Hovenia dulcis fruit extract formulation enhances alcohol metabolism and attenuates alcohol-induced hepatic injury

Food Funct., 2026, 17,4033-4050
DOI: 10.1039/D5FO04017E, Paper

Wool Lim Park, Hye Ji Min, Hyun Dong Cho, Ji An Heo, Hwi Gon Kim, Kwon-Il Seo
A formulation of Citrus unshiu fermented vinegar and Hovenia dulcis fruit extract lowered blood ethanol and acetaldehyde in acute alcohol-treated rats and humans, and attenuated oxidative stress and liver injury in chronic alcohol-fed rats.
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Beyond nutrition: a comprehensive review of the multifaceted benefits of HMOs and Bifidobacterium-based synbiotics during early life

Food Funct., 2026, 17,3824-3841
DOI: 10.1039/D6FO00335D, Review Article

Xiangxin Wang, Qinggang Xie, Jufang Li, Shilong Jiang
Early in life, gut, immunity, growth, and brain development occur rapidly and vary considerably.
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Lactobacillus plantarum RG-034 colonic soluble capsules alleviate functional constipation in rats by promoting short-chain fatty acid generation

Food Funct., 2026, 17,3996-4013
DOI: 10.1039/D5FO02451J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Fenglian Xu, Yi Zhang, Yulong Li, Ziyu Wang, Zijun Liu, Yu Zhao, Yuming Liu, Tengteng Huang, Li Gong, Weirong Fang
Lactobacillus plantarum RG-034 alleviates functional constipation and restores intestinal motility by improving gut microbiota, promoting SCFA production, and activating PI3K/AKT to promote ICC calcium influx and proliferation.
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Therapeutic effects of selenium-enriched rapeseed against triple-negative breast cancer: involvement of Resolvin D5 activation and IL-17 signaling inhibition

Food Funct., 2026, 17,4051-4065
DOI: 10.1039/D5FO05648A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yuxin Lin, Tangyi Wang, Zhijing Wu, Li Wang, Zhiyao Yu, Jiangyun Wang, Tao Liu, Xiaoling Cai, Haoran Li, Yanming Ren, Zhanhai Su, Shoude Zhang, Juan An, Qiong Wu, Haiyan Wang
Dietary selenium-enriched rapeseed mobilizes Resolvin D5 to inhibit the IL-17 pathway and reinvigorate anti-tumor immunity.
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Consumption of an anthocyanin-rich extract increases circulating BDNF and BDNF gene expression in healthy subjects consuming a high-fat meal

Food Funct., 2026, 17,3946-3959
DOI: 10.1039/D6FO00793G, Paper

Wei Zhu, Imani Muhammad, Eleonora Cremonini, Patricia I. Oteiza
Brain-derived neurotrophic factor (BDNF) is a growth factor that has a central role in sustaining brain function.
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Microbial–enzymatic co-fermentation enhanced the beneficial effects of highland barley bran on preventing metabolic disorders and gut microbiota dysbiosis induced by a high-fat diet in obese mice

Food Funct., 2026, 17,3932-3945
DOI: 10.1039/D6FO00739B, Paper

Xuewei Feng, Muyu Feng, Yajun Cui, Junchao Wu, Siqi Zhang, Ting Bai, Yuhong Zhang, Fang Zhong, Yang Yao, Sumei Zhou, Dianzhi Hou
Microbial–enzymatic co-fermentation of HBB elevated its free phenolic content. The resulting product alleviated obesity and metabolic disorders in HFD-fed mice by modulating hepatic lipid synthesis genes and restoring the gut microbiota.
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Yeast protein improves musculoskeletal and systemic functions in mice

Food Funct., 2026, 17,4231-4244
DOI: 10.1039/D6FO01039C, Paper

Xialei Liu, Jin Luo, Yongzhao Bi, Chung-Ying Andy Lee, Shuai Liu, Yuan Ma, Shihao Sun, Lili Zhang, Jialiang Xu
Yeast protein (YP) is rich in high-quality protein and a variety of bioactive compounds and has been shown to confer beneficial effects on overall health.
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The dietary index for gut microbiota, genetically predicted gut microbiome, and the risk of chronic kidney disease: a cohort study

Food Funct., 2026, 17,4275-4286
DOI: 10.1039/D6FO00453A, Paper

Zheng Ma, Yixiao Zhang, Honghao Yang, Gang Zheng, Liuxin Li, Ruiyao Zhang, Xiang Ji, Chao Ji, Yang Xia, Yuhong Zhao
A higher dietary index for gut microbiota (DI-GM) is associated with a lower risk of incident chronic kidney disease in a large prospective cohort, highlighting the role of diet–microbiome interactions in kidney health.
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Ameliorative effects of red-fleshed apple flavonoid extracts (RAFEs) on high-fat diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) in mice

Food Funct., 2026, 17,4153-4170
DOI: 10.1039/D5FO05405B, Paper

Yizhou Chen, Yaqi Dong, Zhaozheng Fan, Shenghui Jiang, Ya Wu, Chengkun Wang, Tongyao Zhu, Zhongkang Wang, Shaoxia Guo, Yugang Zhang, Xiao Liang
Red-fleshed apple flavonoid extracts (RAFEs) rich in isorhamnetin glycosides alleviate high-fat diet-induced MASLD by suppressing hepatic inflammation, oxidative stress, and dyslipidaemia while restoring gut microbiota homeostasis.
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Acute response to a high-saturated-fat, high-refined-carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Food Funct., 2026, 17,4014-4032
DOI: 10.1039/D5FO04456A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Aimee L. Dordevic, Margaret Murray, Michael J. Houghton, Nina M. Trinquet, Nicole J. Kellow, Ralf B. Schittenhelm, Christopher K. Barlow, Kaitlin Day, Louise Bennett, Beau-Luke Colton, Gary Williamson
There is a decrease in plasma oxidative defense proteins after a high-saturated fat high-refined carbohydrate meal.
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Corn silk extract ameliorates cisplatin-induced cardiac injury by restoring mitochondrial function and suppressing ferroptosis

Food Funct., 2026, 17,4090-4109
DOI: 10.1039/D6FO00450D, Paper

Qingxuan Yang, Yumo Li, Li Qi, Jianwen Wang, Mengmeng Liu, Jianhao Huang, Mingyang Sun, Yuheng Fu, He Lin, Zhe Lin, Guangfu Lv, Yuchen Wang
Zea mays L., a traditional edible botanical and abundant agricultural by-product, is rich in polyphenols and flavonoids.
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Modulation and adaptation of gut microbial metabolic functions under probiotic and postbiotic treatment using a novel in vitro anaerobic pseudo-colon system

Food Funct., 2026, 17,4245-4261
DOI: 10.1039/D5FO04976H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Nehal Batra, Prangya Ranjan Rout, Priyankar Dey
Probiotic and postbiotic compounds found in food influence gut microbiota to attenuate chronic metabolic diseases; however, the underlying mechanisms are not yet fully understood.
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Effects of different galactans on DSS-induced colitis and the gut microbiota

Food Funct., 2026, 17,4171-4184
DOI: 10.1039/D6FO00058D, Paper

Xuefei Wei, Chunhua Chen, Shaoping Nie
Nonlinear galactans can significantly alleviate DSS-induced colitis symptoms in mice, and upregulate the abundance of beneficial bacteria. Linear galactans showed no significant alleviative effects, and the gut microbiota remained disordered.
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Acid hydrolysis of jaboticaba (Myrciaria jaboticaba) peel and seed powder increases urolithin excretion in a cross-over clinical trial with normoweight subjects

Food Funct., 2026, 17,3986-3995
DOI: 10.1039/D5FO04952K, Paper

Rafael Bizarelo, Kim Ohanna Pimenta Inada, Daniel Perrone, Mariana Monteiro
This clinical trial with 23 young adults compared urolithin excretion after intake of non-hydrolyzed and hydrolyzed jaboticaba peel and seeds. Acid hydrolysis increased urinary urolithins excretion by 50% without altering the total excretion rate.
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Assessing the diversity and functional profile of the “microbial proteome” in fermented foods

Food Funct., 2026, 17,3960-3971
DOI: 10.1039/D5FO05039A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Laura Winkler, Ayesha Awan, Nicole M. Rideout, Manuel Kleiner
Fermented foods contain a large amount and diversity of microbial proteins which contribute to their nutritional profile.
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Diet, gut microbiota and urinary metabolite profiles associated with lunularin metabotypes in young Chinese adults

Food Funct., 2026, 17,3916-3931
DOI: 10.1039/D6FO00717A, Paper

Shuzhen Zhang, Jing Yang, Wenfeng Luo, Yu He, Junfan Mai, Meiying Li
Lunularin, a specific gut metabolite of resveratrol, shows marked interindividual variability in production, with individuals divided into “lunularin producers” (LPs) and “non-producers” (LNPs); however, the regulatory factors remain unclear.
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Investigating the impact of astaxanthin yogurt on gut microbiota and microbiota-mediated astaxanthin conversion using the SHIME® model

Food Funct., 2026, 17,4201-4212
DOI: 10.1039/D5FO04878H, Paper

Wenmei Zhang, Houyang Sun, Jinyu Zhou, Peixu Cong, Qingjuan Tang
This study aimed to assess the long-term effects of astaxanthin yogurt on the human gut microbiota using the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
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Exopolysaccharide from Weissella confusa HYF86 with sugarcane juice as a substrate alleviates colitis in mice by regulating gut microbiota

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01089J, Paper

Shuai Sun, Jiabin Wu, Shichao Wen, Hangyu Huang, Yaqing Lin, Wenjing Zhang, Yi Zhang, Xiaoying Wang, Lei Pan
Ulcerative colitis is an inflammatory bowel disease with increasing global incidence, which urgently demands safe and sustainable intervention strategies. This work investigated the alleviative effects of exopolysaccharide from Weissella confusa...
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Metabolomic remodeling of pigeon pea by Lacticaseibacillus rhamnosus NTTU 007 reveals anti-obesity effects in high-fat diet rats

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO03084F, Paper

Chin-Feng Liu, Chia-Fang Ao, An-Chi Li, Chun-Lin Lee
Fermentation of non-dairy substrates by lactic acid bacteria can enhance the functional properties of their products.
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Correction: Citrus unshiu fermented vinegar and Hovenia dulcis fruit extract formulation enhances alcohol metabolism and attenuates alcohol-induced hepatic injury

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO90034H, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Wool Lim Park, Hye Ji Min, Hyun Dong Cho, Ji An Heo, Hwi Gon Kim, Kwon-Il Seo
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Dihydromyricetin Attenuates Platelet Hyperactivity in HFD/STZ-Induced Diabetic Mice by Inhibiting Intraplatelet ROS Generation

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00232C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Fenglin Song, Huafang Ding, Yun Chen, Xiangzhen Ge, Ruixue Guo, Fangfang Wu, Yu Guo, Renyou Gan, Zhen-Yu Chen
The interaction between polyphenols and platelets is an emerging area in understanding how diet affects heart disease. Platelet hyperactivity is one of critical drivers of cardiovascular complications in Type 2...
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Carbohydrate quality index and mortality risk in older adults at high cardiovascular risk

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04430H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Héctor Vázquez-Lorente, Stephanie K. Nishi, Sangeetha Shyam, Miguel A. Martínez-González, Dolores Corella, Ramón Estruch, Emilio Ros, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Virginia Esteve-Luque, Nancy Babio, Montserrat Fitó, Estefanía Toledo, José V. Sorlí, Itziar Zazpe, Jordi Salas-Salvadó
Carbohydrate quality may influence long-term health and contribute to lower mortality risk in older adults at high cardiovascular risk.
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Cynarin alleviates apical periodontitis by inhibiting macrophage M1 polarization via the PGC1α/ROS signaling axis

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00014B, Paper

Yao Yang, Min Li, Lifei Pan, Tiezhou Hou, Siyu Hou
Schematic representation of the mechanism by which cynarin attenuates the progression of AP.
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Aloe-emodin alleviates CUMS-induced depressive-like behavior in male C57BL6 mice via neuroinflammation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00655H, Paper

Meijia Shan, Sihan Zhang, Shiyun Chen, Shuaimin Jiang, Mengfei Wang, Ruoyun Wu, Yujia Wang, Fuqin Yang, Wei Li, Wen Li
Flowchart of the study on the antidepressant effects of aloe-emodin.
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Differences in the effects of meal replacement products and traditional dietary control on weight control in obese adults: a 90-day randomized controlled trial

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04853B, Paper

Qiang Hu, Yuyang Wang, Jiamin Jiang, Biandi Li, Botian Chen, Defu Ma
This study compared the weight loss and mtabolic benefits of meal replacement products versus traditional dietary control in Chinese adults with obesity.
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Study on the preparation of postbiotic elements by fermentation of wheat by-products and their role in improving constipation

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04139B, Paper

Jingyang Cai, Jiaqi Wang, Han Li, Aimei Liao, Yinchen Hou, Jihong Huang, Long Pan
Co-fermentation of wheat by-products with L. paracasei produces a postbiotic-rich ingredient that alleviates constipation via a dual-action mechanism, exhibiting an optimal dose–response in restoring gut microbiota and SCFA-5-HT signaling.
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From food plants to functional ingredients for type 2 diabetes: chemotype markers, digestive fate, exposure-informed specifications and sustainable processing

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00752J, Review Article

Ngoc Hong Nguyen, Thuc-Huy Duong, Thi Nhat Thang Nguyen, Huong Thuy Le, Giau Van Vo, Anh Duy Do
Type 2 diabetes mellitus (T2DM) is a lifelong cardio-kidney-metabolic disorder in which durable glycaemic control must be achieved under polypharmacy, variable dietary exposure and constrained healthcare budgets. Edible plants embedded...
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Curcumin attenuates heatstroke-induced myocardial injury and ventricular arrhythmias by regulating the BAX/BCL-2/caspase-3 pathway

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04307G, Paper

Shijie Shao, Baopeng Tang, Junqing Liang, Xiaoyan Wang, Chenxi Xu, Manzeremu Rejiepu, Yali Guo, Limei Wen, Ling Zhang
Curcumin alleviates myocardial injury and ventricular arrhythmias induced by heatstroke by inhibiting the BAX/BCL-2/caspase-3 apoptotic pathway, reversing ventricular electrical and structural remodeling, and restoring cardiac function in rat models.
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Peptidomic profiling of in vitro digesta from diverse microalgae species

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00231E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sara Hamzelou, Damien Belobrajdic, Henri Brook, Wei Chen, Fletcher Hiten, Kim L Chang, Diane Purcell, Utpal Bose, Simone Osborne, Cassandra Pegg, Michelle Lisa Colgrave
Microalgae are a sustainable protein source, yet few species are used for human nutrition.This study evaluated eight species for protein quality, digestibility, and peptide profiles after simulated gastrointestinal digestion using...
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Monitoring in vitro gastric bolus digestion with ultrasound

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D5FO04784F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xinhang Li, Edoardo Capuano, Chris de Korte, Paul Smeets
Monitoring food degradation during gastric digestion is essential to understand how food properties impact nutrient absorption. Imaging techniques like ultrasound can be used to validate in vitro results in vivo....
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Ancient and native fruits from Northwestern Argentina and their derived flours as the next generation of functional foods

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00409A, Review Article

Maria Ines I. Isla, Enzo Agustin Matteucci, Maria Alejandra Moreno, Maria Eugenia Orqueda, Iris Catiana Zampini
Argentina has an incredible biodiversity of non-timber forest products, including edible fruit species with high nutritional value and therapeutic properties that have been used since ancient times by local indigenous...
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Anti-inflammatory effects of gallic acid on chronic bacterial prostatitis: involving target tissue distribution

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05256D, Paper

Xiaomei Liu, Shengjie Kong, Qian Yang, Luyao Ma, Xurui Zuo, Xinyue Liu, Ziqiang Li, Chunxiao Lv, Yuhong Huang
Anti-inflammatory effects of gallic acid on chronic bacterial prostatitis: involving target tissue distribution.
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Triterpenoids from quinoa bran exert anti-colorectal cancer effects via oxidative stress-mediated apoptosis and immune reactivation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00325G, Paper

Meng Zhou, Huiqin Guo, Jin'e Du, Tian Xiao, Haili Wu, Zhuoyu Li
QBT suppresses CRC through a dual mechanism involving direct apoptosis induction and immune activation via ICD.
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Plant proteins for human health: the current status and future needs

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00549G, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kun Gao, Shiyu Zhou, Jiajia Rao, Bingcan Chen
Plant proteins demonstrate great potential as functional components in the development of sustainable and precise nutritional strategies for improved human health.
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Fucoidan alleviates kidney fibrosis by shaping the gut microbiota and modulating tryptophan metabolism

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00785F, Paper

Ying Zhang, Jinxin Li, Wanting Chen, Fengxia Qin, Yuan Tian, Zunjian Zhang, Fengguo Xu, Pei Zhang
Fucoidan mitigates renal fibrosis by remodeling gut microbiota and normalizing tryptophan metabolism. This reveals a novel microbiota–metabolic mechanism underlying its renoprotective effects against chronic kidney disease.
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Fabrication of water-in-oil high internal phase emulsions containing astringent compounds for enhanced oral sensation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00380J, Paper

Haowen Sun, Xinying Wang, Jingjing Yu, Honggao Xu, Like Mao
Astringent compounds (tannic acid or Rosa roxburghii Tratt juice) could be incorporated within the water phase of W/O high internal phase emulsions with improved stability and enhanced oral sensation, which would help to design healthier food containing astringent bioactive compounds.
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Intestinal alkaline phosphatase and gut health: insights into homeostasis, barrier protection, and immune signaling

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO03526K, Review Article

Yue Pang, Jianing Tu, Haiyan Zhang, Jiahui Ma, Lin Zhang, Chenyu Xue, Yuhao Liu, Weichen Hong, Qiyun An, Mizhou Hui, Bailiang Li, Na Dong, Chenzhe Gao
Intestinal alkaline phosphatase (IAP) maintains gut homeostasis by detoxifying LPS, modulating microbiota, and preserving barrier integrity. Its activity is diet-regulated, with delivery systems and personalized nutrition enhancing its application.
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Microfluidization-assisted extraction enhances the functionality and in vitro bioactivity of a guar meal-derived protein isolate: a sustainable approach

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05666G, Paper

Geetarani Liklam Loushigam, Keyur Saliya, Prarabdh C. Badgujar
Guar meal, a protein-rich by-product of guar gum manufacturing, remains underutilized in human nutrition owing to its limited functionality and the presence of anti-nutritional factors.
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Dietary N-acylethanolamines are bioaccessible in the small intestine and modulate postprandial hormonal responses: a randomized crossover trial in subjects with ileostomy

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D5FO03328D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Silvia Tagliamonte, Holly Neill, Brian Murphy, Kirsty Pourshahidi, Francesca De Filippis, Danilo Ercolini, Chris Gill, Natalia Koos, Brendan Curran, Nicole Murray, Mary Slevin, Sara Dobani, Massimiliano Fontana, Paola Vitaglione
N-acylethanolamines (NAEs) are bioactive lipid mediators involved in the regulation of appetite, inflammation, and gut-brain signaling. This study investigated the metabolic fate of dietary NAEs following the consumption of two...
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Lactobacillus reuteri BNCC186563 ameliorates lipid metabolism disorder in obese mice by activating the PPARα signaling pathway

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00358C, Paper

Aibei Zhu, Wenjuan Shen, Bibi Zainab, Xiaohu Luo, Xiping Wu, Yanan Liu
Lactobacillus reuteri ameliorates obesity by activating hepatic PPARα through glycerophospholipid-derived endogenous ligands, leading to suppressed de novo lipogenesis (ACC/FAS) and enhanced fatty acid β-oxidation (CPT-1), thereby reducing hepatic lipid deposition.
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Pine pollen fiber alleviates constipation induced by loperamide in mice: focus on gastrointestinal motility-related hormones, short-chain fatty acids, and gut microbiota changes

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00700G, Paper

Zhiwei Li, Yong Cheng, Dandan Ma, Liduan Yin, Tong Wang, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Jie Chen, Benu Adhikari, Zongping Zheng, Zhiyong He
Constipation, a prevalent gastrointestinal disorder, urgently requires safe and effective intervention strategies.
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Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00638H, Paper

Huiyuan Rui, Xinran Xu, Shuhui Liu, Xueli Gao, Xiaowen Jiang, Wenhui Yu
Curcumin can alleviate kidney damage by regulating the PI3K/AKT signaling pathway, thereby reducing polystyrene nanoplastics-induced renal oxidative stress, inflammatory response, and apoptosis.
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Human milk oligosaccharides shape small intestinal microbiota and epithelial transcriptional profile during early life in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00517A, Paper

Zhongxin Li, Yuxi Shen, Wen Wang, Zhuqing Xie, Qiang Huang, Bin Zhang
2′-fucosyllactose (2′FL) and lacto-N-neotetraose (LNnT) each shape distinct small intestinal microbiota and regulate their metabolites, influencing neonatal gut epithelial function: 2′FL enhances innate immunity and barrier function, whereas LNnT promotes adaptive immune development.
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Bioaccessibility and colonic catabolism of carotenoids from mango purée (cv. Osteen): comparison of ileal fluid content and products of in vitro digestion

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00765A, Paper

Salud Cáceres-Jiménez, Sara Dobani, L. Kirsty Pourshahidi, Chris I. R. Gill, José Luis Ordóñez-Díaz, José Manuel Moreno-Rojas, Alan Crozier, Gema Pereira-Caro
The bioactivity of carotenoids depends largely on their stability during passage through the gastrointestinal tract and subsequent absorption into the circulatory system.
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Dietary β-glucan modulates sucrose preference via gut–brain neuropeptide signaling in a sex-dependent manner in Drosophila

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00187D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jiaojiao Li, Wenyun Li, Yuanchao Li, Jiawen Liang, Yuwei Liu, Gengsheng He
Dietary fiber, especially β-glucan modulates sucrose preference in Drosophila in a sex- and dose-dependent manner, involving coordinated gut–brain neuropeptide signaling and metabolic responses.
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The Influence of Pepper-Derived Compounds on Blood Pressure and Heart Rate: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00419A, Review Article

Peng Chen, Tianyu Liang, Kousalya Prabahar, Jiechao Hu, weiling ye
Various clinical studies have explored capsaicinoids and capsinoids impact on blood pressure and heart rate, findings have been inconsistent. This meta-analysis aimed to systematically evaluate the effects of capsaicinoids, capsinoids,...
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Plant-protein stabilized emulsions as β-carotene delivery systems: colloidal stability and behaviour during in vitro digestion conditions

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05533D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mohsen Ramezani, Marga Amengual Ramon, Laura Salvia-Trujillo, Olga Martín-Belloso
Plant proteins offer a promising clean-label alternative to synthetic surfactants, but their emulsifying properties are strongly dictated by pH.
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Diosmetin's impact on epileptic seizures: a study on inflammatory pathways and neuronal health

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04609B, Paper

Jinhu Zhang, Xu Cao, Xinyi Li, Yi Ding, Yiyu Guo, Qianqian Geng, Jiayi Qiu, Yahong Cheng, Jing Rao
Diosmetin (DM) exerts anti-seizure effects through SIRT1-mediated pathways, suppressing IL-1β, IL-18 and NLRP3 inflammasome, elevating IL-10, and mitigating neuronal damage.
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Impact of pineapple (Ananas comosus [L.] Merr.) processing under low oxygen conditions using an innovative spiral filter press on juice physical characteristics and phytochemical composition

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05382J, Paper

Patricia Esquivel, Víctor M. Jiménez, Vicky Bäumer, Jelena Nagypál, Peter Bach, Claus Patz, Michael Ludwig, Ralf Schweiggert, Christof Björn Steingass
This study compared pineapple (Ananas comosus ‘MD2’) juices produced using either a vacuum-driven spiral filter press (SFP) or a conventional rack-and-cloth press (RCP).
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Associations between degree of food processing, inflammatory biomarkers and colorectal cancer survival: a prospective cohort study

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00196C, Paper

Ya-Wen Tan, Qing-Jian Ou, Huan Xu, Yuan-Yuan Chen, Fang-Ting Lin, Yu-Jing Fang, Cai-Xia Zhang
Higher NOVA 1 consumption was associated with improved OS and CSS among CRC patients, partly through reduced systemic inflammation. Substituting UPFs or NOVA 3 with NOVA 1 may confer additional survival benefits.
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S-Methyl cysteine sulfoxide: its effects on cardiometabolic outcomes in high-fat fed C57BL/6 mice and relevance to human health

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04816H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Caroline R. Hill, Lois Balmer, Hayley Abbiss, Jonathan M. Hodgson, Joshua R. Lewis, Armaghan Shafaei, Lauren C. Blekkenhorst
S-Methyl cysteine sulfoxide (SMCSO) is a sulfur-based compound found in cruciferous and allium vegetables. Higher SMCSO doses blunted high-fat diet-induced increases in HDL-C in mice. The relevance to humans is unclear.
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Exploring the effects of Cheddar cheese intake on vitamin K status and lipid profiles in overweight middle-aged adults

Food Funct., 2026, 17,3784-3793
DOI: 10.1039/D5FO05631D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sitong Zhou, Heleena Moni Bottu, Jean-Christophe Jacquier, Raquel Cama-Moncunill, Mark Timlin, Deirdre Hennessy, Michael O'Donovan, André Brodkorb, Jeremiah J. Sheehan, Eileen R. Gibney, Peter Dunne, Emma L. Feeney
Cheddar cheese intake may improve the vitamin K status, and vitamin K intake from cheese may induce sex-specific effects on blood lipid profiles in overweight middle-aged adults.
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Potential antiobesity and antihepatic steatosis effects of a Capsosiphon fulvescens (maesaengi) ethanol extract: in vitro and in vivo studies

Food Funct., 2026, 17,3764-3783
DOI: 10.1039/D5FO05258K, Paper

Sung Min Lee, Soo-yeon Park, Ji Yeon Kim
Capsosiphon fulvescens ethanol extract (CFE) suppresses lipid accumulation in adipocytes and hepatocytes and attenuates obesity and hepatic steatosis in HFD-fed mice by modulating lipid metabolism-related gene expression.
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Structural activity remodeling of wheat protein peptides during simulated gastrointestinal digestion: insights into antioxidant and enzyme inhibitory functionalities

Food Funct., 2026, 17,3513-3528
DOI: 10.1039/D5FO05244K, Paper

Siyu Hou, Penghui Zhao, Jianyu Huang, Zhizhi Yang, Yinchen Hou, Jicheng Chen
Bioactive food peptides demonstrate potential in chronic disease intervention, yet their structure–activity dynamics during digestion remain poorly understood.
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Evaluation of the underutilized Malpighia glabra L. fruits as a future functional food: nutritional composition, phenolic profile, biological activities, and synergistic effects with pharmaceutical drugs

Food Funct., 2026, 17,3734-3748
DOI: 10.1039/D5FO03782D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Varongsiri Kemsawasd, Sirinapa Thangsiri, Yuraporn Sahasakul, Amornrat Aursalung, Woorawee Inthachat, Piya Temviriyanukul, Suwapat Kittibunchakul, Uthaiwan Suttisansanee
Malpighia glabra L., a non-commercial tropical fruit species in Thailand, was investigated regarding its nutritional composition, phenolic profile, and in vitro biological activities.
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Limosilactobacillus fermentum 50 alleviates vulvovaginal Candidiasis via the gut–vagina axis: modulating microbiota, barrier function and inflammation

Food Funct., 2026, 17,3794-3805
DOI: 10.1039/D6FO00049E, Paper

Xiaoyue Bai, Zhichao Chen, Yizhi Jing, Jiahui Liu, Zheng Han, Qingqiu Ye, Yanling Hao, Zhengyuan Zhai
Vulvovaginal candidiasis (VVC) is a common vaginal disease characterized by inflammatory cell infiltration and vaginal microbiota dysbiosis.
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Resting-state brain connectivity following extra virgin olive oil intake in healthy adults: a randomised crossover pilot neuroimaging substudy

Food Funct., 2026, 17,3477-3483
DOI: 10.1039/D5FO05016B, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Rocío M. Gutiérrez-Romero, Carolina Donat-Vargas, Emma Muñoz-Moreno, Alejandro Hinojosa-Moscoso, Polina Galkina, Camila Arancibia-Riveros, Inés Domínguez-López, Sara Hurtado-Barroso, Maria Pérez, Anna Vallverdú-Queralt, Rosa Casas, Ramón Estruch, Rosa M. Lamuela-Raventós
In this pilot substudy, EVOO intake was associated with higher urinary HT-glucuronide and occipital resting-state connectivity, with an intervention-dependent metabolite-connectivity interaction.
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Integrated transcriptomic and proteomic analyses elucidate the stress tolerance network of Saccharomyces boulardii under gastrointestinal challenge

Food Funct., 2026, 17,3670-3678
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Dingkang Wang, Lerong Liu, Xiaoru Chen, Yiting Kang, Dan Li, Bin Ma, Yuexi Zhu, Yanqin Rong, Hongfei Yu, Yongjie Zhang
The probiotic yeast Saccharomyces boulardii is renowned for its clinical efficacy, which is intrinsically linked to its exceptional ability to survive the harsh gastrointestinal (GI) environment.
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Combined effects of a low-dose multi-target supplement (CaHMB, CBP, and HA) on delaying musculoskeletal aging

Food Funct., 2026, 17,3639-3656
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Open Access

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Haoqi Chen, Junhong Peng, Shanshan Guo, Ting Chen, Si Chen, Xinyuan Jin, Wenge Huang, Chao Xu, Mengchu Li, Mengxing Xie, Mengtao Yang, Jinzhu Pang, Huilian Zhu
A low-dose combination of CaHMB, CBP, and HA delays age-related muscle and bone loss during the transition to old age, with comprehensive benefits potentially mediated by the muscle–bone axis.
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Bioconversion properties of the urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) and its antihyperuricemic capacity via regulating metabolic/immune pathways and gut microbiota

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Hongyu Zhang, Chaoran Li, Tianjiao Li, Fuyu Li, Xiangheng Cao, Yang Yang, Da Wang, Mingyou Yuan, Qiuyi Li, Xuebo Liu, Mengge Zhao
First, omics confirms metabolite changes after fermentation. In HUA mice, FAR and FARS modulate serum cytokines, suppress TLR4/MyD88/NF-κB pathway, and regulate urate-metabolizing factors. Plus, they elevate butyrate via guiding gut bacteria.
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Precision probiotics for overweight management: decoding strain-specific mechanisms to guide microbiota-tailored interventions

Food Funct., 2026, 17,3453-3476
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Unhealthy diets induce gut dysbiosis in overweight individuals, whereas probiotics ameliorate metabolic disorders via microbiota modulation, metabolic regulation, and stress alleviation, yet population heterogeneity leads to varied efficacy.
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Intestinal oxidative stress mitigation and transepithelial anti-inflammatory bioactivity mediated by EtOH-modified supercritical-CO2 coffee pulp extract

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Open Access

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Shuai Hu, Miguel Rebollo-Hernanz, María Martín-Trueba, Vanesa Benítez, Yolanda Aguilera, María Ángeles Martín-Cabrejas, Alicia Gil-Ramírez
EtOH-modified sc-CO₂ coffee pulp extract notably retains bioactive compounds after digestion, boosting antioxidant activity while suppressing NF-κB/MAPK-driven inflammation.
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Diet–microbiota interactions influence pregnancy success in females undergoing artificial insemination: insights from the vaginal microbiota and Mediterranean diet

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Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

M. Gimeno, M. Baizán-Urgell, M. Bernabeu, M. C. Collado, E. Garcia-Verdevio
Adherence to the Mediterranean diet is linked to vaginal microbiota profiles and fertility outcomes in women undergoing artificial insemination.
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Red quinoa hydrolysate as a plant-based therapeutic alternative for damage induced by high cadmium concentrations to the vascular system in rats

Food Funct., 2026, 17,3749-3763
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Open Access

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Samia Hassan Husein Kanaan, Paola Zambelli Moraes, Katye Yasmin de Souza de Oliveira, Fernando Barbosa, José Eudes Gomes Pinheiro, Franck Maciel Peçanha, Dalton Valentim Vassallo, Marta Miguel-Castro, Giulia Alessandra Wiggers
Red quinoa hydrolysate as a plant-based therapeutic alternative for damage induced by high cadmium concentrations to the vascular system in rats.
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