RSC - Food Funct. latest articles

The anti-inflammatory activity of palmitoleic acid from macadamia nuts

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00826G, Paper

Wen-Hui Sun, Ya-Zhuan Li, Wen Dai, Chin-Ping Tan, Xiao-Song Rong, Yong-Jiang Xu
POA intervention may attenuate LPS-induced oxidative stress through the NRF2/TBK1/lysosomal axis, thereby alleviating inflammation.
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Unleash the Power of Citrus: Functional Activity and Delivery of Citrus Secondary Metabolites

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D5FO04960A, Review Article

Zhangshuang Deng, Aiyang Liu, Ruoyun Zhang, Yunshan Cheng, Ying Wang
Citrus fruits are widely cultivated globally due to their exceptional contributions in energy supply, nutritional value, and health supplementation. Citrus-derived secondary metabolites, including flavonoids, phenolic acids are crucial for human...
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Lactobacillus plantarum ameliorates high-fat-diet-induced dyslipidemia via cholesterol metabolism and gut microbiota modulation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00519E, Paper

Ziyue Zhou, Yin Mao, Jinyang Li, Ju Yang, Yihui Zhang, Yunying Zhao, Yu Deng
Dyslipidemia, a typical metabolic disorder, is predominantly characterized by elevated levels of total cholesterol (TC) and/or triglycerides (TG), with disruption of cholesterol homeostasis serving as a significant contributing factor.
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Pumpkin (Cucurbita maxima) seed extract ameliorates letrozole and high-fat diet-induced PCOS in rats via SIRT1/AMPK/NF-κB signaling

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00600K, Paper

SUHASINI SIDRAMAESHWAR, Martin Asha
Polycystic ovarian syndrome (PCOS) is a multifactorial metabolic endocrine disorder that affects reproductive-aged women. While previous studies have established the role of pumpkin seed in the management of metabolic disorders...
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Animal-based diets and the human gut microbiota: an integrative review combining metagenomic profiling and graphical synthesis of diet–microbiota associations

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00371K, Review Article

Lamia Medouni-Haroune, Sonia Medouni-Adrar, Lynda Messaoudene, Samira Negrichi, Cilia Bouiche, Yasmine Sahraoui-Remini, Ayoub Allam, Zoubeida Meghlaoui, Khokha Mouhoubi, Amina Abbou, Nassim Brahimi, Mohamed Khalil Mellal, Zoubir Sari, Khodir Madani
This review integrates metagenomic profiling of 899 human gut metagenomes with a literature-based graphical synthesis to map associations between animal-based foods and gut microbiota composition in non-diseased individuals.
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Taurine supplementation at the crossroads of metabolism, inflammation and aging: mechanistic and nutritional perspectives

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01808D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Benedikt Justus Beine, Melissa Castellano, Jarlei Fiamoncini, Karsten Hiller
Taurine, the most abundant free amino acid in mammals, supports mitochondrial function and regulates inflammation. Supplementation can improve metabolic health and promote healthy aging, highlighting its potential as a dietary modulator in nutrition.
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Anti-inflammatory activity of orange peel aqueous extract and hesperidin : Integrated evidence from neutrophil assays, in vivo models, and in silico analyses

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00864J, Paper

Tinhinane Rekeb, Samia Bedouhene, Nassima Senani, Sahra Amel Belambri, Meriem- Dehbia Chabane, R Ksouri, My-Chan Pham, Jamel El Benna
Citrus peels have traditionally been used for their anti-inflammatory properties. Their bioactive compounds can modulate neutrophil activation and reduce ROS production, both of which play key roles in the development...
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The hawthorn (Crataegus pinnatifida) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01304J, Paper

Xue Han, Yuchen Fang, Huanyu Wang, Anni Fu, Jianfeng Sun, Zhiqiang Wang, Lei Ma
Hawthorn procyanidin extract (HPC) is one of natural plant-derived polyphenol with lipid-lowering and liver-protective properties, while its therapeutic mechanisms against nonalcoholic fatty liver disease (NAFLD) require further clarification.
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Alleviating effects of 2′-fucosyllactose combined with Bifidobacterium longum BB536 on loperamide-induced constipation and depressive-like behavior

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00474A, Paper

Zhongmei Tan, Zihao Tian, Xiaolei Duan, He Zhang, Wei Yu, Qinggang Xie, Dong Xu, Yingying Ding, Rongbiao Ying, Jiage Ma, Qiqi Ren
This study evaluated the effects and underlying mechanism of 2′-fucosyllactose and Bifidobacterium longum BB536 on relieving loperamide-induced constipation and depressive-like behavior.
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Aged garlic extract suppressed macrophage-mediated inflammation in acute respiratory distress syndrome

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00337K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Shun Nakazawa, Shinsaku Togo, Chisato Tadokoro, Soichiro Soma, Yuta Arai, Hiroaki Motomura, Yuichi Nagata, Takuto Sueyasu, Haruki Hirakawa, Koichi Kurata, Issei Sumiyoshi, Yusuke Ochi, Junko Watanabe, Hiroaki Ihara, Kazuaki Hoshi, Motoyasu Kato, Kazuhisa Takahashi
Combining aged garlic extract (AGE) with low-dose dexamethasone broadens and enhances the suppression of pulmonary inflammation in ARDS by inhibiting NF-κB signaling, offering a potent therapeutic approach with reduced steroid side effects.
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Effects of microalgae incorporation on nutrient digestibility and antioxidant activity of gluten-free muffins after simulated chewing and digestion in adults and older adults

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01526C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Milagros Arnal, Susana Ribes, Nuria Belenguer, Pau Talens
This study evaluated the effects of microalgae incorporation, chewing conditions, and digestive models on nutrient digestibility, total phenolic content, and antioxidant activity of gluten-free muffins using in vitro boluses produced in a rheometer.
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Gut Microbiota-Dependent Metabolism of 6-Shogaol Generates Bioactive Metabolites That Mediate Its Anti-Inflammatory Effects

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01722C, Paper

Shuwei Zhang, Yantao Zhao, Rachel C Newsome, Yingdong Zhu, Christian Jobin, Shengmin Sang
a 6-Shogaol (6S), a major bioactive constituent of ginger, exhibits anti-inflammatory activity, but the contribution of gut microbiota to its metabolism and biological effects remains unclear. Using germ-free (GF) and...
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Integrating sustainability and nutrition: comprehensive valorisation of vegetable by-products for bioactive food applications

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00309E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tatiane C De Oliveira, Tayse F.F. da Silveria, Dejan Stojkovic, Javier Cano-Lou, Gema Casado, Susana Machado, Liliana Espírito Santo, Beatriz Oliveira, Eliana Pereira, Lillian Barros
Valorising vegetable by-products is a sustainable and innovative strategy to reduce food waste and develop functional ingredients. This study investigated onion peel (Allium cepa L.), kale (Brassica oleracea L. var....
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Protective Efficacy and Related Mechanism of a new ADH Activating Peptide YRPG from Lactococcus lactis Against Acute Alcohol-Induced Injury

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO01977C, Paper

Anran Feng, Beijie Li, Sisi Chen, Shiyu Zhao, Zhangning Qiao, Yanling Shi, Laizheng Lu, Juan juan Yi, Jike Lu
Excessive alcohol intake can cause severe acute alcohol injury (AAI). Alcohol dehydrogenase (ADH)-activating peptide is an effective means to alleviate this injury. This study investigated the protective effects of the...
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Tibetan kefir grain-fermented milk attenuates DSS-induced colitis through coordinated regulation of intestinal barrier function, inflammation, and gut microbiota

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01565D, Paper

Ben Li, Shuai Li, Yihao Pei, Xiaojuan Sun, Chen Ding, Jin Yu, Meiling Zhou, Jianmei Han, Hong Yang, Yafan Wan
This study links the complete kefir-fermented milk matrix to colitis prevention through integrated host, microbiota, metagenomic, and metabolomic analyses.
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Apples and apple-based products in the modulation of cardiometabolic and functional markers: a systematic review of human intervention studies

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05460E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Cristian Del Bo’, Daniela Martini, Anna Giancristofaro, Marco Rendine, Mirko Marino, Maria Cristina Casiraghi, Patrizia Riso
Apple is one of the most widely consumed fruits worldwide, yet its effects on human health remain the subject of ongoing debate.
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Non-ethanol components of Baijiu alleviate ethanol-induced energy metabolism disorder and gut microbiota dysbiosis in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00947F, Paper

Yingrui Gao, Weiman Zhao, Ruonan Tong, Xiaojun Wu, Zhengtao Wang, Longchan Liu, Li Yang
Baijiu non-ethanol components restore ethanol-induced energy metabolism disorder and microbiota dysbiosis, normalize the NADH/NAD⁺ redox balance, and reduce lactate overaccumulation, thereby relieving ethanol-induced oxidative stress.
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Coordinated changes in microbiota features, short-chain fatty acids, and peripheral clocks accompany fructo-oligosaccharide–associated metabolic improvement

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO02286C, Paper

Zhenting Zhao, Junwei Zhang, Pei Du, Xinran Liu, Jin Ye, Renjie Shi, Danna Wang, Bing Xia, Xuebo Liu, Beita Zhao
Metabolic disorders induced by a high-fat diet (HFD) are closely linked to disruptions in the circadian regulation of glucose and lipid metabolism.
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Latilactobacillus sakei ZFM232 alleviates age-related lipid metabolism disorders and enhances antioxidant defense in Caenorhabditis elegans

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01144F, Paper

Gang Wang, Yubin Zhang, Fengxuan Wang, Wanting Xiao, Wan Zhou, Xiangfeng Chen, Qing Gu, Ping Li
Lactic acid bacteria (LAB) are widely recognized as beneficial microorganisms within the human microbiome; however, the mechanisms underlying their health-promoting effects remain largely elusive.
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Dietary chlorogenic acid improves lipid metabolism through modulation of the gut–liver microbiota axis in hyperlipidemic mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00434B, Paper

Abdul Basit, Abdul Mueed, Raheem Shahzad, Wang Rong, Khanizadeh Shahrokh, Adeeb Shehzad, Salman Khan, Tao Shutian
Chlorogenic acid alleviates high-fat diet-induced hyperlipidaemia and glucose dysregulation by modulating gut microbiota, remodeling metabolite networks, reducing hepatic lipid accumulation, and activating IRS1/CD36 signalling pathways.
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Inhibition of the in vitro colonic fermentation of cooked gluten by dietary fibers with individual fermentability

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00694A, Paper

Dan Yuan, Tianyi Li, Ying Li, Xingyu Tao, Zhiming Gao, Yuehan Wu, Wenxin Jiang, Yanlei Li, Xuewen Ni, Mengzhou Zhou
Alginate inhibited gluten fermentation by shielding gut microbiota from degrading gluten due to its durable fermentability. FOS inhibited gluten fermentation only for a short period of time. Cellulose even promoted gluten fermentation.
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Selenium-enriched Tibetan kefir grain-fermented goji juice attenuates patulin-induced liver injury and is associated with gut microbiota modulation in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01305H, Paper

Yifan Cheng, Jinyi Yang, Jinyue Xu, Xuejun Zeng, Kewei Feng, Yahong Yuan, Tianli Yue
Selenium-enriched Tibetan kefir grain-fermented goji juice attenuated patulin-induced liver injury by improving redox balance, reducing inflammation, and modulating gut microbiota-associated responses.
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Nut consumption as a therapeutic strategy to preserve brain function, attenuate neuropathology, and modulate cross-tissue microRNAs in a mouse model of Alzheimer's disease

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00445H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Laura Panisello, Mireia Millet-Sigalat, Nil Novau-Ferré, Javier Mateu-Fabregat, Marina Carrasco, Miren Ettcheto, Elisa Félix-Soriano, antoni camins, M. Bullo
Nutritional modulation of brain metabolism is emerging as a key strategy for preventing Alzheimer’s Disease (AD), with potential to influence key pathologies such as Aβ accumulation, tau phosphorylation, and neuroinflammation....
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Lactobacillus_rhamnosus GG reverses zearalenone-induced pathological macrophage polarization to restore placental angiogenesis and efficiency

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00618C, Paper

Peiqiang Yuan, Bin Feng, Yan Lin, Shengyu Xu, Lun Hua, Yong Zhuo, Lianqiang Che, De Wu, Zhengfeng Fang
Zearalenone (ZEN) induced abnormal M2-type polarization of placental macrophages, impaired placental angiogenesis and efficiency. Lactobacillus rhamnosus GG alleviated ZEN-induced placental damage by altering macrophage polarization.
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Sturgeon roe protein hydrolysate alleviates cyclophosphamide-induced ovarian dysfunction in mice with reduced ovarian oxidative-inflammatory injury, granulosa-cell apoptosis, and HPO-axis-related endocrine imbalance

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO02422J, Paper

Silu Zhang, Hailong Li, Lijia Yang, Penglong Liu, Tingfeng Zhang, Yangyan Dai, Yuchen Pang, Shijing Ma, Mouming Zhao, Tiantian Zhao
Chemotherapy-associated ovarian dysfunction is closely linked to oxidative–inflammatory injury of the follicular microenvironment, granulosa-cell loss, impaired steroidogenesis, and destabilized hypothalamic–pituitary–ovarian (HPO) axis feedback. This study evaluated sturgeon roe protein hydrolysate...
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Food-derived peptides for senile sarcopenia: mechanisms of action, structural characteristics, and in vivo delivery challenges

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00948D, Review Article

Manqun Wang, Wanlu Liu, Jiulong An, Xinting Luo, Janar Jenis, Xinqi Liu, He Li
Food-derived peptides (FDPs) are attracting increasing research attention for intervention in age-related sarcopenia due to their potential muscle-protective activity.
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Akkermansia muciniphila alleviates diabetic cognitive impairment by inhibiting NLRP3 inflammasome activation and ameliorating hippocampal synaptic defects

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO03902A, Paper

Yage Du, Yu An, Zhaoming Cao, Guangyi Xu, Ming Chu, Yanhui Lu
This study demonstrates that the probiotic Akkermansia muciniphila alleviates diabetic cognitive impairment by inhibiting NLRP3 inflammasome activation and improving synaptic function in mice, revealing a novel therapeutic strategy.
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Application of artificial intelligence in synbiotic and functional food development for precision nutrition

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00295A, Review Article

Janani B., Samuel Ayofemi Olalekan Adeyeye
Artificial Intelligence enables data-driven design of synbiotic foods by integrating multi-omics data, optimizing formulation, and predicting functional outcomes for precision nutrition.
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Adhering to dietary guidelines does not yield flavanol intake levels associated with beneficial cardiovascular effects

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00867D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Javier I. Ottaviani, John W. Erdman, Francene M. Steinberg, JoAnn E. Manson, Howard D. Sesso, Hagen Schroeter, Gunter G. C. Kuhnle
Adherence to dietary guidelines does not yield flavanol intakes comparable to those shown to provide cardiovascular benefits in COSMOS. Dietary reference values for flavanols may be necessary to increase the intake of these dietary compounds.
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Folic acid enhances intestinal stem cell-mediated epithelial regeneration depending on β-adrenergic receptor signaling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01675H, Paper

Yi Zheng, Yu Han, Yuhui Zhang, Yecheng Xu, Shouchuan Jiang, Xin Wen, Xi Qiao, Yuanyuan Zhang, Yunqin Li, Huahua Du
Folic acid, a water-soluble B vitamin, is well known for its critical roles in neural tube development and its contributions to neonatal gut maturation and overall gut health.
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Phyllanthus emblica L. polysaccharides attenuate anxiety disorder-like behavior in high-fat diet-fed mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01214K, Paper

Yu-Tien Huang, Sheng-Yi Chen, Yi-Hsien Hsu, Gow-Chin Yen
Phyllanthus emblica L. polysaccharides (PEP) reduce anxiety disorder-like behavior by inhibiting inflammatory pathways (TLR4, MyD88, NF-κB) and dual-regulating the AMPK/mTOR axis in high-fat diet-fed mice.
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Plant-derived exosome-like nanoparticles ameliorate glycolipid metabolism diseases: molecular mechanism, advances and bottlenecks

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01315E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xue Li, Ran An, Hairong Wang, Shiya Yuan, Xu Shi
Glycolipid metabolism diseases, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), are increasingly becoming a significant global public health burden.
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Chlorella vulgaris as a functional food and nutraceutical: bioactive composition, health-promoting mechanisms, applications, and current challenges

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00663A, Review Article

Muhammad Abdur Rehman Shah, Fengzheng Gao, Feifei Zhu, Xinjuan Hu, Sadaf-Ilyas Kayani, Ammar AL-Farga, Sirasit Srinuanpan, Shuhao Huo
The increasing demand for sustainable and nutrient-dense food sources has intensified interest in microalgae like Chlorella vulgaris (C. vulgaris).
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Diphlorethohydroxycarmalol isolated from Ishige okamurae improves age-related muscle dysfunction by Ca2+-dependent response via the SirT1/PGC-1α pathway in vitro and in vivo

Food Funct., 2026, 17,5185-5196
DOI: 10.1039/D5FO05213K, Paper

Xueyu Wang, Chan-Young Kim, Jun-Geon Je, Yu-Jin Roh, Fengqi Yang, Hye-Won Yang, You-Jin Jeon
DPHC from brown algae Ishige okamurae stimulates the release of Ca²⁺ from the sarcoplasmic reticulum, activates the AMPK/SirT1/PGC-1α signaling pathway, and reduces ROS production, thereby resisting age-related muscle dysfunction.
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Xylitol ameliorates ASD-like behavior in Chd8+/− mice via modulations of the gut microbiome, neurotransmitters, and dendritic spine morphology

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01006G, Paper

Meng Sun, Xin Wang, Qian Zhang, Ziyi Wang, Jianhong Luo, Junyu Xu, Xiaoqiong Li
Autism spectrum disorder (ASD) is a neurodevelopmental condition with complex etiology involving gut–brain axis interactions.
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An innovative germination-driven LAB fermentation strategy for allergenicity reduction in soymilk gels through spatiotemporal protease-mediated epitope disruption

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04998A, Paper

Yaqiong Wang, Shijie Fang, Zhihao Fan, Yi Wang, Yue Wu, Xin Rui, Pei Wang, Chong Xie, Runqiang Yang
This study innovatively integrated seed germination (1–3 days) with LAB fermentation to establish a structure–immunomodulation nexus in fermented soymilk gels.
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Cyanidin and delphinidin inhibit transglutaminase 2 and mitigate inflammatory effects of IFN-γ and TNF-α by molecular interaction

Food Funct., 2026, 17,4865-4879
DOI: 10.1039/D6FO00704J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Andrea Diers, Silvia Rudloff, Heike Hausmann, Anika E. Wagner, Sebastian Stricker
Enzymatic modification of gliadin peptides by calcium-dependent transglutaminase 2 (TG2) plays a central role in the pathogenesis of celiac disease (CD) and is considered a potential therapeutic target.
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Associations of dietary diversity with type 2 diabetes in two Chinese cohorts: a multi-omics study

Food Funct., 2026, 17,5142-5151
DOI: 10.1039/D6FO01294A, Paper

Boya Zhao, Yuwei Li, Siyu Li, Nuo Xu, Yuwei Shi, Yuji Yu, Weifang Zheng, Yi-Hsuan Wu, Emily Hu, Po-Kai Huang, Eunhye Lee, Chi Chang, Ying Lu, Esther M. John, Ann W. Hsing, Wei He, Shankuan Zhu
The role of overall dietary diversity in type 2 diabetes (T2D) risk remains uncertain, and the potential associations involving the gut microbiota and metabolism are poorly understood.
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Correction: Water-soluble tomato concentrate alleviates neuron apoptosis through activating ERK/CREB/BDNF signaling pathway in ischemic stroke

Food Funct., 2026, 17,5197-5197
DOI: 10.1039/D6FO90038K, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Liang Zhou, Miao Yu, Yunqi Zhang, Ruikun He, Xiao Sun, Yun Luo, Xiaobo Sun
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Oatmeal-based fiber diet outperforms resistant starch-based fiber diet in lowering serum uric acid via gut microbiota–metabolite interactions: a randomized controlled trial

Food Funct., 2026, 17,5118-5129
DOI: 10.1039/D5FO05505A, Paper

Tianze Li, Zhijun Lu, Wei Peng, Jiawang Liu, Jialin Yuan, Lewei Zhu, Yueqin Zhou, Chen Yang, Yanna Zhu
Soluble dietary fiber outperforms insoluble fiber in lowering serum uric acid: a randomized controlled trial.
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Effects of live and heat-treated Limosilactobacillus fermentum PS150 on circadian rhythms and GABAergic signaling in a caffeine-induced insomnia mouse model

Food Funct., 2026, 17,5095-5105
DOI: 10.1039/D6FO00048G, Paper

Chin-Lin Huang, Ting-Yang Hsieh, Ching-Ting Lin, Chien-Chen Wu, Ying-Chieh Tsai
PS150 and HT-PS150 may alleviate caffeine-induced sleep disturbances by modulating circadian signaling, GABAergic neurotransmission, and gut microbiota.
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Digestion characteristics of yeast protein and identification of bioactive peptides with cytoprotective effects against LPS-induced injury in C2C12 myoblasts

Food Funct., 2026, 17,5152-5169
DOI: 10.1039/D6FO01092J, Paper

Xin Cao, Hongjuan Liu, Miao Yang, Zhixian Chen, Qian Cheng, Jialin Sun, Xudong Wu, Yan Zhang, Liping Hao
Yeast protein (YP) exhibited sustained amino acid release during INFOGEST digestion and generated diverse bioactive peptides. Selected peptides showed potential bioactivity and alleviated LPS-induced injury in C2C12 myoblasts.
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(Poly)phenol profiles of plant-based diets assessed through dietary intake and urinary biomarkers

Food Funct., 2026, 17,5047-5063
DOI: 10.1039/D6FO01259K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

E. Casas-Albertos, N. M. Rodriguez-Martín, A. Alcalá-Santiago, M. Reina-Borrego, P. Keski-Rahkonen, J. Marchiandi, B. Sarriá, E. Ruiz-Moreno, C. Piernas, M. D. Ruiz-López, B. García-Villanova, E. J. Guerra-Hernández, A. Castelló-Pastor, R. Zamora-Ros, E. Molina-Montes
(Poly)phenol profiles of plant-based diets assessed through dietary intake and urinary biomarkers in the OMIVECA study.
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Evaluation of in vitro fermentation characteristics and tolerance of lactose-free milk powder for lactose intolerant subjects

Food Funct., 2026, 17,5170-5184
DOI: 10.1039/D5FO05589J, Paper

Sisi Xiong, Weixin Xu, Jiale Si, Yanlong Wen, Wenyi Zhang, Sufang Duan, Ziyi Wang, Jia Li, Yadong Zhong, Lian Yang, Yanyan Zhao, Yuqin Xi, Dongyue Ouyang, Yang Liu, Zhijian He, Tianle Feng, Yuanyuan Tang, Jian He, Ming Li, Jielun Hu
The global prevalence of lactose malabsorption (LM) ranges from 65% to 70%, even reaching 100% in some Asian regions, while that of lactose intolerance (LI) remains unclear due to diagnostic complexity.
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Stevioside extends the healthspan and improves Alzheimer's disease and increases oxidative stress resistance via the mitochondrial unfolded protein response

Food Funct., 2026, 17,5021-5031
DOI: 10.1039/D6FO00251J, Paper

Xiaocong Li, Yi Xiao, Fang Liu
Stevioside extends the healthspan and improves Alzheimer's disease and increases oxidative stress resistance by ATFS-1-mediated UPR^mt.
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Fucoxanthin ameliorates experimental autoimmune encephalomyelitis by inhibiting microglial NLRP3 inflammasome

Food Funct., 2026, 17,5006-5020
DOI: 10.1039/D5FO04970A, Paper

Xiaoqian Dong, Linlin Zhang, Yuxin He, Jiayu Zhang, Huichan Zhou, Yingxia Zhang, Junjian Li, Rong Wang, Da-Qi Zhang
Fucoxanthin, an algal compound, attenuates EAE by inhibiting microglial M1 polarization and NLRP3-mediated pyroptosis, suggesting its potential as a therapy for multiple sclerosis.
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Probiotic Lactobacillus kefiranofaciens K6 attenuates physiological and behavioral alterations and modulates the gut microbiota in a mouse model of overtraining syndrome

Food Funct., 2026, 17,4988-5005
DOI: 10.1039/D6FO00574H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yen-Po Chen, Ming-Han Gao, Wen-Chi Wei, Wen-Ching Huang
Excessive training induced metabolic, inflammatory, behavioral, and gut microbiota alterations in an OTS-like mouse model. Lactobacillus kefiranofaciens K6 supplementation was associated with attenuation of these changes.
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Protein hydrolysates and xanthine oxidase inhibitory peptides from sunflower capitulum exert antihyperuricemic effects: a comprehensive study based on serum metabolomics and gut microbiota analysis

Food Funct., 2026, 17,4972-4987
DOI: 10.1039/D6FO01257D, Paper

Xiaoyu Liu, Liyan Ma, Zhuoyan Fan, Jiaxing Fan, Wanlong Lu, Lei Zhang, Jingming Li
Comparative evaluation of sunflower capitulum protein hydrolysate and the xanthine oxidase inhibitory peptide LGDF reveals distinct antihyperuricemic effects through purine metabolism, serum metabolomics, and gut microbiota modulation.
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Prebiotic activity and antidiabetic potential of Ginkgo isomalto-oligosaccharides

Food Funct., 2026, 17,4914-4924
DOI: 10.1039/D6FO00811A, Paper

Yu Chen, Xinyi Zhang, Tingting Li, Caie Wu, Gongjian Fan, Xiaojing Li, Dandan Zhou, Yang Song
This study compares Ginkgo isomalto-oligosaccharides (G-IMO) with corn-derived IMO (C-IMO) to evaluate their prebiotic and antidiabetic potential.
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Causal associations of dietary habits and blood metabolites with Parkinson's disease risk

Food Funct., 2026, 17,4880-4898
DOI: 10.1039/D5FO02160J, Paper

Jikuang Zhao, Liangzhe Wei, Mingyue Zhao, Hangyu Sheng, Xu Yan, Sheng Nie, Yi Huang
Parkinson's disease (PD) is a neurodegenerative disorder with unclear etiology, though dietary factors and metabolic alterations are implicated.
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Ultrasonic modulation of amyloid fibrillization in Antarctic krill protein for enhanced iron delivery

Food Funct., 2026, 17,4819-4833
DOI: 10.1039/D6FO00210B, Paper

Jinhui Hu, Xueqing He, Yihan Huang, Songyi Lin, Na Sun
Ultrasound regulates the structure of amyloid fibrils from krill protein. This greatly enhances iron binding and enables sustained Fe²⁺ release.
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Ameliorative effect of docosahexaenoic acid-acylated astaxanthin ester on diabetic nephropathy: association with the trehalose/HSP90AA1 and colon–kidney axis

Food Funct., 2026, 17,5064-5080
DOI: 10.1039/D6FO00946H, Paper

Jialin Yin, Xu Deng, Yanqi Hu, Fang Zheng, Huali Meng, Xiaoli Huang, Kebo Wang, Xiaodong Zhao, Lei Sun, Hao Wu
DHA–AST ameliorates diabetic nephropathy through its colonic metabolite trehalose, which downregulates HSP90AA1 expression.
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Fungal exosome-like nanoparticles ameliorate exercise capacity and metabolic health in sleep-deprived mice by modulating the gut microbiota

Food Funct., 2026, 17,4899-4913
DOI: 10.1039/D5FO05659D, Paper

Haotian Zhao, Wenlong Sun, Guoliang Yin, Fengming Zhang, Hongkang Zhu, Chang Liu, Naiyan Lu
Fungal exosome-like nanoparticles (FELNs) derived from black truffles represent an emerging class of bioactive nanovesicles with potential therapeutic applications, yet their effects on sleep deprivation (SD)-induced impairments remain unexplored.
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Barley extrudates modulate the gut microbiome–metabolome axis in vitro through β-glucan fermentation and polyphenol biotransformation

Food Funct., 2026, 17,4834-4849
DOI: 10.1039/D6FO00601A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mariona Martínez-Subirá, María Engracia Cortijo Alfonso, Iván Friero, Alba Macià, Ramona N. Pena, Natalia Molinero, M. Victoria Moreno-Arribas, Laura Rubió-Piqué, Marian Moralejo
Extrusion-tailored barley matrices modulate the gut microbiome–metabolome axis, enhancing butyrate and microbial phenolic metabolites.
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Oleacein prevents metabolic dysfunction-associated hepatic steatosis and dyslipidaemia in ApoE-KO mice

Food Funct., 2026, 17,4850-4864
DOI: 10.1039/D5FO05134G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Beatriz Ormonde, Vânia Costa, Pedro Vieira, André Alves, Sofia Viana, Flávio Reis, Fátima Paiva-Martins
Oleacein improves blood lipid profile and reduces hepatic lipid accumulation in steatotic ApoE-KO mice.
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Peptidomic profiling of in vitro digesta from diverse microalgae species

Food Funct., 2026, 17,5130-5141
DOI: 10.1039/D6FO00231E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sara Hamzelou, Damien Belobrajdic, Henri Brook, Wei Chen, Fletcher Hiten, Kim Lee Chang, Diane Purcell, Utpal Bose, Simone Osborne, Cassandra Pegg, Michelle L. Colgrave
Protein quality, digestibility, and peptide profiles after simulated gastrointestinal digestion in microalage.
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Monitoring in vitro gastric bolus digestion with ultrasound

Food Funct., 2026, 17,5081-5094
DOI: 10.1039/D5FO04784F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xinhang Li, Edoardo Capuano, Chris L. de Korte, Paul A. M. Smeets
Ultrasonography can non-invasively capture structural degradation under controlled in vitro gastric digestion. Grey value and image features of ultrasound images can characterize boli, as indicators of digestibility and physical transformation.
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Ancient and native fruits from Northwestern Argentina and their derived flours as next generation functional foods

Food Funct., 2026, 17,4776-4802
DOI: 10.1039/D6FO00409A, Review Article

M. I. Isla, E. A. Matteucci, M. A. Moreno, M. E. Orqueda, I. C. Zampini
Native Argentine fruits and flours connect biodiversity, health, and food innovation for sustainable functional foods.
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Hypouricemic and renal protective effects of the Chinese functional tea Ligustrum robustum on hyperuricemic mice

Food Funct., 2026, 17,4925-4940
DOI: 10.1039/D6FO00994H, Paper

Xiao-Long Tian, Zuo Zheng, Qian Wang, Jun-Yan Ran, Ying-Cai Zhang, Dong-Mei Zhou, Xin Lang, Li Jiang, Xue-Long Yan, Xiang Fang, Shang-Gao Liao
Ligustrum robustum showed hypouricemic and renoprotective effects by reducing uric acid production, promoting excretion, regulating transport, and suppressing TNF/NF-κB inflammation.
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Immunoprogramming by maternal fibre and polyphenol intake enhances humoral systemic and mucosal immunity in adult offspring

Food Funct., 2026, 17,4957-4971
DOI: 10.1039/D5FO04563K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sergi Casanova-Crespo, Daniela Ceballos-Sánchez, Maria José Rodríguez-Lagunas, Malén Massot-Cladera, Margarida Castell, Francisco José Pérez-Cano
Maternal diet is an element of the exposome that could shape the immune development in mothers’ offspring.
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Dietary N-acylethanolamines are bioaccessible in the small intestine and modulate postprandial hormonal responses: a randomized crossover trial in subjects with ileostomy

Food Funct., 2026, 17,5106-5117
DOI: 10.1039/D5FO03328D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Silvia Tagliamonte, Holly R. Neill, Brian Óg Murphy, Kirsty L. Pourshahidi, Francesca De Filippis, Danilo Ercolini, Chris I. R. Gill, Koos Natalia, Brendan Curran, Murray Nicole, Slevin Mary, Sara Dobani, Massimiliano Fontana, Paola Vitaglione
Dietary NAEs are released from the food matrix into the small intestine and modulate gut hormone responses through nutrient sensing.
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The influence of pepper-derived compounds on blood pressure and heart rate: a systematic review and meta-analysis of randomized controlled trials

Food Funct., 2026, 17,4762-4775
DOI: 10.1039/D6FO00419A, Review Article

Peng Cheng, Tianyu Liang, Kousalya Prabahar, Jiechao Hu, Weiling Ye
Various clinical studies have explored how capsaicinoids and capsinoids impact blood pressure and heart rate, but findings have been inconsistent.
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Poria cocos polysaccharide alleviates multidrug-resistant Klebsiella pneumoniae-induced acute lung injury by modulating the gut–lung axis via gut microbiota remodeling

Food Funct., 2026, 17,5032-5046
DOI: 10.1039/D6FO01450J, Paper

Yifei Xiang, Shuxin Zhu, Renhe Wang, Jingsheng Huang, Han Li, Dejia Dai, Yunmei Yang, Hao Hu, Yingyi Wei, Tingjun Hu, Jiakang He, Zhengmin Liang
Poria cocos polysaccharide relieves MDR-KP-induced acute lung injury through regulation of the gut microbiota and barrier, an effect that is weakened upon gut microbiota depletion.
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Oleic and omega-3 fatty acids buffer neuroinflammation in a scopolamine model with Alzheimer's-like features via target-level interactions

Food Funct., 2026, 17,4941-4956
DOI: 10.1039/D6FO00279J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Marlua Albertuni, Maria Torrecillas-Lopez, Teresa Gonzalez-de la Rosa, Luna Barrera-Chamorro, Elvira Marquez-Paradas, Jose L. del Rio-Vazquez, Maria D. Navarro-Hortal, Carmen M. Claro-Cala, Sergio Montserrat-de la Paz
Diet quality, beyond total fat, may shape brain immune tone in Alzheimer's-relevant contexts.
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Human milk oligosaccharide 2′-fucosyllactose attenuates oxidative stress-induced intestinal barrier injury in mice via regulating microbial tryptophan metabolism

Food Funct., 2026, 17,4803-4818
DOI: 10.1039/D5FO05555E, Paper

Jie Zhong, Wanxin Xiang, Zhaoxi Xie, Dongmei Li, Fucheng Lu, Yong Zhang, Pan Zhou, Lingbin Liu, Honglin Yan
2′-Fucosyllactose alleviates diquat-induced intestinal barrier injury by reshaping the gut microbiota and activating the microbial tryptophan metabolite-derived AHR pathway.
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Polyphenol combinations improve quercetin absorption and inhibit carbohydrate digestion while reducing glucose transport

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00569A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

C. G. M. Dohmen, M. M. J. P. E. Sthijns, R. Slotboom, F. J. Troost
High sugar intake promotes obesity and type 2 diabetes. Quercetin potently inhibits α-glucosidase and reduces glucose uptake. Polyphenol mixtures enhance α-amylase inhibition, increase quercetin absorption, without effecting fructose transport.
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The effect of high-protein vs. low-protein diets on CRP, IL-6, TNF-α, and liver enzymes in adult participants: a systematic review and meta-analysis

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04706D, Review Article

Xue Ma, Pejman Rohani, Mohammad Hassan Sohouli
High-protein diets (HPDs) are widely recommended for weight management and preservation of lean mass, but their impact on systemic inflammation and liver health remains controversial.
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Unraveling the Anti-inflammatory Mechanism of Dolichos lablab Flower Extract: Synergistic Action of Bioactive Flavonoids via Multi-target Modulation

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D5FO05546F, Paper

Xiaojie Xu, Siwen Wang, Chao Ding, Qi Lu, Minghua Zhu
Abstract：Dolichos lablab Flos (DLF), a medicinal and edible homologous plant, possesses rich nutritional and medicinal value. This study aimed to systematically characterize its bioactive compounds and elucidate their antioxidant and...
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Chloroplasts as ingredients for food: a review

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO03797B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

David A. Gray, Poramat Sutcharit, Jutarat Wattanakul, Mohamed A. Gedi, Ruth Price, Ardeshir Farmanfarmaian, Randa Darwish, Syamila Mansor, Chao Chi, Malgorzata Walczak, Rhianna Briars, Joshua E. S. J. Reid, Vincenzo Di Bari, Joanne Gould, Molly Muleya, Robert Rintoul, Lorna Mcausland, Moulay Sahaka, Frédéric Carrière
The chloroplast is best known for its role in photosynthesis, the process by which sunlight energy is converted into chemical energy in the form of sugar. This image is created using Biorender.
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Correction: Genetic risk modifies the effect of exogenous nucleotides on insulin resistance in older adults: insights from multi-omics analyses

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO90042A, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ruisheng Fu, Shuyue Wang, Yuxiao Wu, Xueying Qin, Tao Huang, Yong Li, Meihong Xu
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Marine phlorotannin trifuhalol A coordinately regulates endothelial nitric oxide signaling and ACE activity to maintain vascular homeostasis

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00790B, Paper

Fengqi Yang, D S Dissanayake, Aaron Taehwan Kim, Dineth P Nagahawatta, You-Jin Jeon
Hypertension and vascular dysfunction are closely linked to endothelial nitric oxide (NO) deficiency and dysregulation of the renin–angiotensin and kallikrein–kinin pathways. In this study, the vascular health–related biofunctionality of Trifuhalol...
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Impact of tomatoes and tomato-derived products on obesity and cardiometabolic health: a systematic review and meta-analysis

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00495D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lea Sani, Lourdes Mounien, Jean-François Landrier
This article provides modest but biologically consistent evidence on the role of tomato and tomato-based product intake on several parameters linked to adiposity and obesity.
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Advances in starch-based binary and ternary complexes with lipids and proteins: mechanisms, digestibility, and applications in low-glycemic foods

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00809G, Review Article

Feng Mei, Wang Ping-Ping, Fu Xiong, Chen Chun
Multi-scale defense mechanisms of starch–lipid–protein complexes against enzymatic digestion. The ternary complex suppresses starch digestion via a series of multi-level defense mechanisms spanning from the macroscopic to the molecular level.
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Integrating Network Pharmacology and MALDI-MSI Spatial Metabolomics Revealing Ellagic Acid as the Key Anti-Pharyngitis Agent in Fructus Chebulae and its Key Metabolic Pathways in Pharyngeal Tissues

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D5FO05286F, Paper

Yifei Kong, Chao Wang, Ya Zhang, Xingping Luo, Fangdi Hu, Juan Chen, Xinyue Chen
Background: Current pharyngitis treatment relies heavily on antibiotics and glucocorticoids, leading to increasing bacterial resistance and significant adverse drug reactions. The traditional efficacy of Fructus Chebulae is to reduce swelling...
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Association between dietary polyphenol intake and polyphenol-utilizing bacteria in healthy adults

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00158K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Stephanie M. G. Wilson, Andrew Oliver, Zeynep Alkan, Bhimanagouda S. Patil, Mary E. Kable, Danielle G. Lemay
We examined diet recalls and fecal microbiomes from healthy adults and found that people consuming more diverse polyphenols had more microbial genes involved in breaking down polyphenols, as well as more microbes carrying those genes.
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Goal orientation is a key determinant of healthy dietary behaviour change in European adults receiving personalised vs. non-personalised nutrition advice

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO03197D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mariette Abrahams, Brendan P. Bunting, Lynn J. Frewer, Katherine M. Livingstone, John C. Mathers, Barbara J. Stewart-Knox
Although personalised nutrition is more effective than generic approaches to dietary health promotion, effect sizes tend to be small.
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Daily supplementation with egg yolk lipids from two eggs alleviated cognitive impairment in 5 × FAD mice by restoring neuronal and synaptic function and regulating gut microbiota

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00928J, Paper

Le Cheng, Yifei Wang, Yumeng Ma, Chenyan Zheng, Zihan Wang, Fang Wu, Bing Fang
DHA-enriched egg yolk lipids (two eggs daily) alleviate 5 × FAD mouse cognitive deficits by promoting neuronal survival, improving synaptic plasticity, suppressing neuroinflammation, and remodeling gut microbiota and neuroprotective metabolites.
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Microbiota dynamics and their impact on the metabolite in lupin oat yoghurt analogues

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05594F, Paper

Damodar Dhakal, Zijian Liang, Pangzhen Zhang, Jeremy J. Barr, Dinesh Subedi, Sushil Dhital
The growing demand for nutritious, flavour-rich plant-based yoghurt analogues calls for innovative fermentation strategies.
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Association of ultra-processed foods (UPFs) with hypertriglyceridemic waist (HTGW) phenotype, oxidative stress, and inflammation in Iranian adults: a cross-sectional study

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05626H, Paper

Reyhane Rostamian, Mahdi Moabedi, Donya Poursalehi, Zahra Moradmand, Farnaz Shahdadian, Parisa Rouhani, Parvane Saneei
In this study, we evaluated the association between UPFs with HTGW in relation to oxidative stress and inflammation in Iranian adults, as no previous study had assessed these altogether.
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Lactiplantibacillus plantarum KLDS1.0344 ameliorates depressive-like behavior in CUMS mice: integrative multi-omics evidence linking gut microbiota alterations to sphingolipid and glycerophospholipid metabolic pathways

Food Funct., 2026, Accepted Manuscript
DOI: 10.1039/D6FO00143B, Paper

Fangfei Dou, Yuxing Li, Wenqing Lv, Yuqi Sun, Meiqi Li, Bailiang Li, Yupeng Wang, Wei Yu
Depression is a common and debilitating psychiatric disorder, and current pharmacotherapies are often limited by delayed onset, variable efficacy, and adverse effects. Therefore, safer and more effective adjunctive or alternative...
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Mediterranean diet adherence and dietary fat intake in relation to lung cancer outcomes: a prospective cohort study

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00080K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Qiyun Xue, Huakang Tu, Yan Liu, Shiyu Jiang, Lizhi Zhang, Fang Hu, Qingfeng Hu, Min Yang, Xifeng Wu
Adherence to the Mediterranean diet and higher polyunsaturated fatty acid intake independently relate to lower lung cancer risk and mortality. Their combination may provide additional benefits for lung cancer post-diagnosis survival.
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The importance of oral processing of bean-based wraps with different microstructures on starch digestion: an in vivo and in vitro study

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00876C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Esther Staes, Dorine Duijsens, Serafien Lefever, Lieza Theuwissen, Masha Mikhalski, Ann Van Loey, Tara Grauwet
How does oral processing affect starch digestion in bean-based wraps?
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Oleuropein and hydroxytyrosol enhance mitochondrial function and biogenesis in SH-SY5Y cells through estrogen-like mechanisms

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00178E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Manuela Leri, Daniele Nosi, Diletta Ami, Federica Bovio, Matilde Forcella, Federica Carnemolla, Paolo Mereghetti, Paola Fusi, Antonino Natalello, Massimo Stefani, Niccolò Taddei, Monica Bucciantini
EVOO-derived OleA and HT activate estrogen-like neuroprotective pathways, enhancing mitochondrial fitness, metabolic efficiency, and neuronal survival against age-related decline.
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A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of chronic oyster mushroom intervention in healthy older adults

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO04951B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sara Cha, Lynne Bell, Jessica Eastwood, Derek R. Fisher, Barbara Shukitt-Hale, Zicheng Zhang, Ana Rodriguez-Mateos, Claire M. Williams
Pleurotus ostreatus oyster mushrooms demonstrate potential to maintain mood, improve memory, and reduce inflammation in older adults.
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3-Fucosyllactose and 3′-sialyllactose combined with Lacticaseibacillus rhamnosus 1.0320 alleviate necrotizing enterocolitis by modulating the gut microbiota and regulating NF-κB/Nrf2 pathways

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05215G, Paper

Juncai Hou, Xiaolei Duan, Hao Shi, Jing Zhang, Zhanmei Jiang, Zhongmei Tan, Zihao Tian, Xiangyu Li, Qingyun Wang
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease that primarily affects premature infants.
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Metabolomic insights reveal bioactive enhancement in fermented oat-based beverages via Lactobacillus plantarum

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00493H, Paper

Open Access

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Aly Castillo, Matteo Capietti, Cristina Megias, Javier Olleros, Fabio Días, Bernardo Ordás, Gerardo Alvarez-Rivera, Marta Lores
This study evaluates the impact of thermal processing and fermentation with Lactobacillus plantarum on the bioactive composition and metabolic profile modulation of an oat-based (Avena sativa) beverage.
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Yellow tea extract ameliorates dexamethasone-induced hepatic steatosis by modulating the gut–liver axis and reshaping microbial metabolites: a multi-omics insight

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01620K, Paper

Pengfei Ren, Zhipeng Kan, Biqian Wei, Wanting Qin, Shangyun Lu
Multifaceted protection via the gut–liver axis.
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Stereoselective pharmacokinetics and anti-inflammatory activity of amygdalin epimers: implications for thermal and pH stability in amygdalin-based functional foods

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00961A, Paper

Wenkang Liu, Xianrun Hu, Maojie Zhou, Fujie Cai, Sitong Zhang, Jinchun Lei, Wenna Ma, Shenglan Qi, Wei Liu, Changhong Wang
Compatibility or processing conditions influence the stability of amygdalin (Amy), which in turn affects its bioactivity and in vivo pharmacokinetics.
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Pomelo-derived exosomes suppress vesicular stomatitis virus infection through GSK3β dependent regulation of innate immune signaling

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00968A, Paper

Zhanzhi Ren, Lishan Huang, Dan Guo, Chengyu Li, Jing Zhang, Huaming Tao, Xingang Yao, Wenyu Wu
Pomelo-derived extracellular vesicles, especially after sodium alginate encapsulation, show anti-VSV activity and may regulate GSK3β/STAT1-related innate immune signaling.
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Sulforaphane reprograms the metabolomic landscape of chronic kidney disease: insights from NMR-based metabolomics

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00047A, Paper

Marcia Ribeiro, Ludmila F. M. F. Cardozo, Natália A. Borges, Larissa Manhães, Aline D. Pereira, Mauricio Luis Sforça, Gustavo H. Rodrigues da Silva, Denise Mafra
Chronic kidney disease (CKD) promotes metabolic dysregulation. Sulforaphane supplementation modulates metabolic pathways and antioxidant defenses, suggesting a potential therapeutic strategy to improve metabolic alterations in CKD.
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Dietary polyphenols as modulators of the microbiota–gut–brain axis in depression and anxiety: a preclinical perspective

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05615B, Review Article

Levi Nascimento Bellinazzi, Iara Lopes Lemos, Agatta Caroline de Souza, Giulianna Genizelli, Angela Giovana Batista, Mario Roberto Marostica Junior
Dietary polyphenols modulate gut microbiota, increasing SCFAs and reducing inflammation. Through the gut–brain axis, they preserve gut barrier integrity, attenuate neuroinflammation, and improve neurotransmission and behavior.
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Integrated RNA-seq and network pharmacology analyses suggest PI3K–Akt and NF-κB pathway modulation in the protective effects of diosmin against experimental colitis

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01388K, Paper

Shuo Wang, Cheng Tan, Haodong He, Xiangyun Li, Miao Xu, Xingzhou Guo, Yafei Liu, Fei Liao, Weiguo Dong
Ulcerative colitis (UC), a chronic inflammatory bowel disease, remains difficult to treat due to incomplete understanding of its mechanisms and limited therapeutic options.
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Effects of different proportions of structural fats on cognitive function and body weight in mice

Food Funct., 2026, Advance Article
DOI: 10.1039/D5FO05678K, Paper

Quanzhang Li, Ting Li, Suqi Wei, Meng Wei, Sufang Duan, Zeyuan Deng, Jing Li
Human milk's unique triglyceride composition modulates lipid metabolism, reducing weight gain and enhancing cognition in mice, offering insights for improved infant formula design.
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Quercetin attenuates neutrophil extracellular trap formation in uveitis through orchestrating the cGAS–STING signaling pathway

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00799F, Paper

Congling Wang, Bin Liu, Yuecong Sun, Yuan Peng, Yane Gao, Huixia Wei, Bo Bao, Xuewei Yin, Hongsheng Bi, Dadong Guo
Quercetin attenuates NET formation in uveitis by regulating the cGAS–STING pathway.
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Immunomodulatory effect of rice bran peptides on RAW264.7 cells

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01738J, Paper

Wei Lin, Xinlai Sui, Xiaolan Liu, Xiqun Zheng
Rice bran peptides (RBPs) activate macrophages and enhance phagocytosis, demonstrating potential as novel dietary immunomodulators for improving immune function.
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Neochlorogenic acid attenuates endothelial injury in diabetic ApoE−/− mice by suppressing NF-κB mediated NLRP3 inflammasome activation

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO00170J, Paper

Yung-Che Tsai, Kuei-Chuan Chan, I-Ning Tsai, Ping-En Ko, Hui-En Hsu, Meng-Hsun Yu, Chau-Jong Wang
Diabetes mellitus (DM) significantly increases global morbidity and mortality through cardiovascular complications, particularly atherosclerosis, characterized by chronic inflammation, oxidative stress, and endothelial dysfunction.
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Noni (Morinda citrifolia L.) fruit juice induces ferroptosis in gastric cancer cells via the Nrf2/HO-1–GPX4 axis

Food Funct., 2026, 17,4699-4716
DOI: 10.1039/D5FO03232F, Paper

Open Access

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Zhihao Xie, Hejiao Li, Weifeng Lu, Lijie Liu, Dianxiao Liao, Chunmeng Mai, Xian Fu, Minni Zhang, Xiuying Tian, Xinbao Hao, Lu Xu
Investigating the inhibition of gastric cancer growth and the induction of lipid peroxidation triggering ferroptosis by noni (Morinda citrifolia L.) juice highlights the potential of functional foods in cancer intervention.
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Exopolysaccharides from Weissella confusa HYF86 with sugarcane juice as a substrate alleviate colitis in mice by regulating gut microbiota

Food Funct., 2026, Advance Article
DOI: 10.1039/D6FO01089J, Paper

Shuai Sun, Jiabin Wu, Shichao Wen, Hangyu Huang, Yaqing Lin, Wenjing Zhang, Yi Zhang, Xiaoying Wang, Lei Pan
Weissella confusa HYF86 exopolysaccharide from sugarcane juice alleviates ulcerative colitis in mice by improving gut barrier function, regulating gut microbiota, and increasing butyric acid production.
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Metabolomic remodeling of pigeon pea by Lacticaseibacillus rhamnosus NTTU 007 reveals anti-obesity effects in high-fat diet rats

Food Funct., 2026, 17,4664-4683
DOI: 10.1039/D5FO03084F, Paper

Chin-Feng Liu, Chia-Fang Ao, An-Chi Li, Chun-Lin Lee
Fermentation of non-dairy substrates by lactic acid bacteria can enhance the functional properties of their products.
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Correction: Citrus unshiu fermented vinegar and Hovenia dulcis fruit extract formulation enhances alcohol metabolism and attenuates alcohol-induced hepatic injury

Food Funct., 2026, 17,4747-4748
DOI: 10.1039/D6FO90034H, Correction

Open Access

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Wool Lim Park, Hye Ji Min, Hyun Dong Cho, Ji An Heo, Hwi Gon Kim, Kwon-Il Seo
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