RSC - Integr. Biol. latest articles

Building risk-on-a-chip models to improve breast cancer risk assessment and prevention

Integr. Biol., 2013, Advance Article
DOI: 10.1039/C3IB40053K, Frontier

Pierre-Alexandre Vidi, James F. Leary, Sophie A. Lelievre
Modifiable (green) and nonmodifiable (red) factors cooperatively define breast cancer risk and need to be studied into biosensors-equipped physiologically relevant 'risk-on-a-chip' models for cancer prevention studies.
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Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells

Integr. Biol., 2013, Accepted Manuscript
DOI: 10.1039/C3IB40027A, Paper

Ana Margarida Barradas, Veronica Monticone, Marc Hulsman, Charlene Danoux, Hugo Fernandes, Zeinab Tahmasebi, Florence Barrere, Huipin Yuan, Marcel Reinders, Pamela Habibovic, Clemens A. van Blitterswijk, Jan de Boer
Calcium phosphate (CaP) based ceramics are used as bone graft substitutes in the treatment of bone defects. The physico-chemical properties of these materials determine their bioactivity, meaning that molecular and...
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Live imaging reveals active infiltration of mitotic zone by its stem cell niche

Integr. Biol., 2013, Accepted Manuscript
DOI: 10.1039/C3IB20291G, Paper

Brandon G Wong, Adrian Paz, Michael A Corrado, Brian R Ramos, Amanda Cinquin, Olivier Cinquin, Elliot E Hui
Stem cells niches are increasingly recognized as dynamic environments that play a key role in transducing signals that allow an organism to exert control on its stem cells. Live imaging...
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In vivo screening of extracellular matrix components produced under multiple experimental conditions implanted in one animal

Integr. Biol., 2013, Advance Article
DOI: 10.1039/C3IB40023A, Technical Innovation

Gustavo A. Higuera, Jeanine A. A. Hendriks, Joost van Dalum, Ling Wu, Roka Schotel, Liliana Moreira-Teixeira, Mirella van den Doel, Jeroen C. H. Leijten, Jens Riesle, Marcel Karperien, Clemens A. van Blitterswijk, Lorenzo Moroni
Cartoon depicting the in vivo screening concept.
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Astrocyte neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

Integr. Biol., 2013, Accepted Manuscript
DOI: 10.1039/C3IB40022K, Paper

Anja Kunze, Sylvain Lengacher, Elisabeth Dirren, Patrick Abischer, P. J. Magistretti, P Renaud
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. ALS is believed to be a non-cell autonomous condition, as other cell types, including astrocytes have been implicated in...
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Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Integr. Biol., 2013, Advance Article
DOI: 10.1039/C3IB40049B, Paper

Kyung-Jin Jang, Ali Poyan Mehr, Geraldine A. Hamilton, Lori A. McPartlin, Seyoon Chung, Kahp-Yang Suh, Donald E. Ingber
Human kidney proximal tubule-on-a-chip lined by living cells exposed to fluidic flow mimics proximal tubular morphology, function and drug toxicity responses.
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Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

Integr. Biol., 2013, Advance Article
DOI: 10.1039/C3IB20245C, Paper

Suzanne Geenen, James W. T. Yates, J. Gerry Kenna, Frederic Y. Bois, Ian D. Wilson, Hans V. Westerhoff
A key role of the antioxidant glutathione is detoxification of chemically reactive electrophilic drug metabolites within the liver.
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Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity

Integr. Biol., 2013, 5,807-816
DOI: 10.1039/C3IB20265H, Paper

Jessica D. Lang, Scott M. Berry, Ginny L. Powers, David J. Beebe, Elaine T. Alarid
Dynamic expression of Estrogen Receptor-alpha, a clinically used biomarker, was used to functionally measure the impact of complex, soluble microenvironment components on growth of breast cancer cells.
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Personalised treatment of haematological malignancies through systems medicine based on single molecules in single cells

Integr. Biol., 2013, 5,759-767
DOI: 10.1039/C3IB20258E, Review Article

Ehsan Ghayoor Karimiani, Philip Day
Molecular diagnostics in haematological malignancies continues to advance towards more personalized treatment and accordingly demand is increasing for procedures providing quantitative analyses of heterogeneous tissue in malignancies.
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Expansion of breast cancer stem cells with fibrous scaffolds

Integr. Biol., 2013, 5,768-777
DOI: 10.1039/C3IB20255K, Paper

Sheng Feng, Xinrui Duan, Pang-Kuo Lo, Shou Liu, Xinfeng Liu, Hexin Chen, Qian Wang
Electrospun polycaprolactone fibrous scaffolds can serve as a 3D-like environment to enrich the population of cancer stem cells and promote epithelial to mesenchymal transition in breast cancer cell lines.
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Anodic aluminium oxide membranes for immunoisolation with sufficient oxygen supply for pancreatic islets

Integr. Biol., 2013, 5,828-834
DOI: 10.1039/C3IB20226G, Technical Innovation

Siwoo Cho, Sangmin Lee, Seong Hee Jeong, Yeongae Kim, Song Cheol Kim, Woonbong Hwang, Jaesung Park
Polyethylene glycol coated anodic aluminum oxide membranes performed selective exclusion of immunoglobulin G with a suitable transportation rate of insulin, oxygen and glucose for rat pancreatic islets to survive and function.
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Single-molecule imaging in vivo: the dancing building blocks of the cell

Integr. Biol., 2013, 5,748-758
DOI: 10.1039/C3IB40018B, Tutorial Review

Miguel Coelho, Nicola Maghelli, Iva M. Tolic-Norrelykke
A cell can be viewed as a dynamic puzzle, where single pieces shuffle in space, change their conformation to fit different partners, and new pieces are generated while old ones are destroyed. In this review we discuss the lessons that can be learned from single-molecule imaging in vivo.
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Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration

Integr. Biol., 2013, 5,817-827
DOI: 10.1039/C3IB20280A, Technical Innovation

Joseph C. Hoffmann, Jennifer L. West
We have developed two-photon laser scanning lithography to provide control of the cellular microenvironment through the patterning of adhesive ligands in PEG-based hydrogels. Cell migration was then guided by these adhesive micropatterns and 2D and 3D cell motility were characterized under various patterned conditions.
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A model of membrane contraction predicting initiation and completion of bacterial cell division

Integr. Biol., 2013, 5,778-795
DOI: 10.1039/C3IB20273A, Paper

Claire E. Dow, Alison Rodger, David I. Roper, Hugo A. van den Berg
Bacterial cell division involves a complex and dynamic sequence of events whereby polymers of the protein FtsZ assemble at the division plane and rearrange to achieve the goal of contracting the cell membrane at the site of cell division, thus dividing the parent cell into two daughter cells.
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Efficient transcription initiation in bacteria: an interplay of protein-DNA interaction parameters

Integr. Biol., 2013, 5,796-806
DOI: 10.1039/C3IB20221F, Paper

Marko Djordjevic
As the first, and usually rate-limiting, step of transcription initiation, bacterial RNA polymerase binds to double stranded DNA and subsequently opens the two strands of DNA.
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Influence of pressurized cyclic stretch and endothelial cell presence on mesenchymal stem cell osteogenic commitment

Integr. Biol., 2013, Accepted Manuscript
DOI: 10.1039/C3IB20186D, Paper

Andrea Carolina Jimenez-Vergara, Dany J Munoz-Pinto, Mariah S Hahn
Applied mechanical stretch and blood vessel invasion are key stimuli to which progenitor cells are exposed in post-natal endochondral bone formation. Understanding the combined effects of cyclic stretch and endothelial...
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Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model

Integr. Biol., 2013, Advance Article
DOI: 10.1039/C3IB00008G, Paper

Alireza Salmanzadeh, Elizabeth S. Elvington, Paul C. Roberts, Eva M. Schmelz, Rafael V. Davalos
Independent of the expression of specific oncogenes commonly associated with aggressive ovarian cancer, sphingolipid metabolites differentially regulate the dielectrophoretic properties of MOSE cells as determined by cDEP.
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An actin length threshold regulates adhesion maturation at the lamellipodium/lamellum interface

Integr. Biol., 2013, Advance Article
DOI: 10.1039/C3IB20282H, Paper

Y. Loosli, C. Labouesse, R. Luginbuehl, J.-J. Meister, J. G. Snedeker, B. Vianay
We provide quantitative experimental evidence of a length threshold mechanism for tangential actin bundle stabilization and adhesion maturation, using adhesive micropatterns.
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