RSC - Lab Chip latest articles

Region-Specific Proteomic Profiling of Brain Interstitial Fluid via a Micro-invasive Sampling Platform

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00038J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Qun Cao, Hannah D Jackson, Aidan J. Duncan, Yufei Cui, Haley O Higginbotham, Stella Lesnik, Yunseo Jo, Jiaquan Yu, Forest White, Michael J Cima
Interstitial fluid (ISF) within the brain parenchyma contains secreted factors related to brain function, metabolism, and neurodegenerative disorders. Cerebrospinal fluid (CSF) is commonly sampled due to its accessibility in well-defined...
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Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01131K, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Doriane Le Manach, Vincent Senez, Matthias Nees
CAF-driven matrix remodeling creates quantifiable transport barriers to drug delivery. Tumor-on-chip platforms enable transport phenotyping to decode and target these stromal barriers.
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Microparticle-enabled single cell multiparameter electronic immunophenotyping for selective electroporation

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00180G, Paper

Madeline Hoyle, Josiah Rudge, Yuvraj Rallipalli, Aniruddh Sarkar
Detection of multifrequency impedance signatures of microparticle labeled single cells in a 3D printed microfluidic channel enables real time selective electroporation of cell subpopulations for cell engineering.
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A 3D-printed electromagnetically actuated microgripper system for precision single-cell manipulation

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00081A, Paper

Xi Chen, Qingying Ren, Wenshuo Zhao, Minhao Wang, Yining Guo, Jing Huang, Xuhui Zhao, Xinyu Lu, Yuan Liu, Haifeng Xu
A 3D-printed electromagnetic microgripper enabling controllable single-cell manipulation with stable actuation and a liquid-retention structure.
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A hypoxic microfluidic organoid-on-a-chip system for studying the efficacy of metronidazole-modified nanomaterials against cholangiocarcinoma established within the chip

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01198A, Paper

ao xie, Zipeng Yao, Qijun Du, Mengjiao Xia, Qinrui Lu, Jiashu Wang, Wenqi Hu, Lin Wu, Chenwei Sun, Youlong Yang, Di Wu, Haijie Hu, Guohua Wu, Shuqi Wang
Cholangiocarcinoma (CCA) is a highly aggressive biliary malignancy characterized by a dismal prognosis. Tumor progression relies heavily on the hypoxic tumor microenvironment (TME), a key factor that promotes drug resistance...
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Facile fabrication of high-density two-dimensional micronozzle arrays using twisted thin-wire molds

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00036C, Paper

Koki Takahashi, Kyohei Terao
Rotational skewing of thin-wire arrays enables simple fabrication of dense micronozzle arrays with independently connected channels, allowing localized hydrodynamic flow confinement and microscale liquid processing.
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A rapid in-situ synthesis of bioinspired nanoflowers on a microfluidic dipstick for point-of-care diagnosis of normoglycemic glycosuria †

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00086J, Paper

Saminu Abdullahi, Mohamed Ishag Hassan Gama, Mubashir Ali, Zhu Yang , Han Yujia, Jingzhen Li, Yuhang Liu, wang xuzhong, Zedong Nie
Reliable detection of urinary glucose is crucial for the early diagnosis of renal tubular dysfunctions, including normoglycemic glycosuria (NG), a condition characterized by glucose excretion despite normal blood glucose levels....
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A Tunable 50 MHz Acoustic Vortex Tweezers for Size-Selective Manipulation and Cell Pre-concentration

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00010J, Paper

Xiongwei Wei, Xin Wang, Lili Miao, Yi Quan, Chunlong Fei, Yintang Yang
In microfluidic bioanalysis, efficient target manipulation, enrichment, and sample pretreatment are key bottlenecks. Although high-frequency ultrasound (>50 MHz) can provide tens of micrometers resolution and enable precise non-contact manipulation, existing...
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Highly Sensitive Wireless Dual-Spiral Resonant Contact Lens for Continuous Intraocular Pressure Monitoring

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC00940E, Paper

Ying Liu, Zhixian Chen, Xiaoyu Zhao, Lin Xu, Shengli Mi
Continuous and non-invasive intraocular pressure (IOP) monitoring is crucial for managing glaucoma, a leading cause of irreversible blindness worldwide. However, existing tonometry methods are intermittent and lack the capability to...
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A compact low-power valveless piezoelectric micropump with a nested rectification structure

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00060F, Paper

Jie Shan, Aoyu Ma, Cuixue Ren, Yuren Zhao, Lixia Yang, Jingmin Li
The field of implantable medical devices imposes stringent requirements on piezoelectric micropumps, particularly in terms of low-power operation, miniaturization, and backflow suppression. This study proposes a novel valveless piezoelectric micropump...
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Numerical microfluidic chip modeling of laminar vortex dynamics induced by biomineralization in evolving porous media

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01002K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yajie Chu, Dianlei Feng
A 3D numerical microfluidic chip reveals the evolution of precipitation, vortices, and mixing during biomineralization. Precipitate alters pore geometry, inducing vortices that impact mixing.
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Sequential Intracellular Delivery of Genetic Coding Molecules Using an Acoustic Electric Microfluidic Platform

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC00941C, Paper

Michelle Zhang, Aida Z Taravatfard, Mohammad Aghaamoo, Abraham Phillip Lee
Intracellular delivery of genetic coding molecules is a critical step in both fundamental cell biology and the development of cellular and gene therapies. With the emergence of diverse genetic coding...
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Bioinspired quality-based sperm sorting in a spiral microfilter-enhanced microfluidic device: enhancing DNA integrity via rheotaxis and boundary dynamics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00427F, Paper

Donya Shahhoseini, Naser Naserifar
A bioinspired spiral microfluidic device leverages rheotaxis and boundary dynamics for label-free sperm sorting, reducing DNA fragmentation and enhancing viability, providing a practical solution for challenging semen in assisted reproduction.
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Topology-Based Coordination Control for Multi-Droplet Tasks in Autonomous Digital Microfluidics

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00147E, Paper

Zhen Gu, kunlun guo, Zerui Song, Boyi Feng, Tiaofen Qiu, Jiale Zhou, Bin Shen, Bingyong Yan, Hui-Feng Wang
Digital microfluidics (DMF) is a versatile technique for parallel and field-programmable control of individual droplets. The challenge of large-scale parallel droplet manipulation in DMF is essentially a cross-scale complex system...
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Band-stop microfluidics for high-purity, label-free enrichment of viable cancer cells from whole blood

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00039H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lewis Krzeczkowski, Georgios Nteliopoulos, Simak Ali, Paul Davey, R. Charles Coombes, Ali Salehi-Reyhani
A microfluidic band-stop filter selectively enriches viable CTC-sized cells from undiluted whole blood while excluding smaller and larger blood cells. Captured cells remain viable, can be drug-tested on-chip, and recovered off-chip.
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Robotic acoustofluidic single-cell picking and placement platform

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01129A, Paper

Wanqi Li, Qiu Yin, Jiahui Wu, Chenfan Zhang, Xiaochen Li, Chenyang Zhou, Xianting Ding, Xiang Chen
Single-cell manipulation is essential for investigating cellular heterogeneity and enabling downstream assays, such as single-cell proteomics and drug screening.
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Correction: Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC90032A, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ali Khademhosseini, Judy Yeh, George Eng, Jeffrey Karp, Hirokazu Kaji, Jeffrey Borenstein, Omid C. Farokhzad, Robert Langer
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High-Throughput Microfluidic Platform for Modelling Inflammatory Responses of Human Articular Chondrocytes under Variable Fluid Shear Stress

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01167A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Aldeliane Maria da Silva, Priscila C Rodrigues, Meriem Lamghari, Hoang-Tuan Nguyen, Jere Kettunen, Sebastien Mosser, Prateek Singh, Ali Mobasheri, Gabriela Lorite
Inflammation plays a critical role in osteoarthritis (OA), a debilitating joint disease characterized by cartilage degradation, chronic pain, and disability. The absence of approved disease-modifying OA drugs underscores the need...
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High-speed liquid switching and on-chip force sensing reveal the transient mechanical response of MscL in Synechocystis sp. PCC 6803

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00004E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xu Du, Masaru Tsujii, Nobuyuki Uozumi, Fumihito Arai
High-speed liquid switching with on-chip force sensing enables millisecond extracellular regulation and quantification of the transient mechanical response of a single cell during osmotic stimulation.
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An automated and portable platform for rapid cell-free DNA isolation and its application in microbial DNA metagenomic sequencing from human blood samples

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00876J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Linda Marriott, Ana Martinez-Lopez, Antonio Liga, Kazuhiro Horiba, Amanda Warr, Jacob N. Phulusa, Radhe Shantha Kumar, Laura Carey, Yoshinori Ito, Benjamin J. Parcell, Nicholas R. Leslie, Nicholas A. Feasey, Shevin T. Jacob, Jamie Rylance, Maïwenn Kersaudy-Kerhoas
CNASafe, a portable automated platform, rapidly isolates plasma cfDNA with yields comparable to standard kits, enabling real-time nanopore sequencing and detection of pathogens missed by blood culture within hours.
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Cap-Sweat: a capillary microfluidic platform for digitized sweat sampling and time-resolved biomarker analysis

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01172H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pezhman Jalali, Amir Sanati Nezhad
Wearable capillary device for time-resolved sweat analysis.
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Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01063B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ling Ding, Huizi Zhang, Yao Li, Jun Kameoka
A stitched lyocell–modal microfluidic platform guides saliva to a microneedle-based electrochemical sensor, providing a simple route for low-concentration lactate detection in human saliva.
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Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00067C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Louis P Widom, Panteha Torabian, Michelle A Trempel, Molly C McCloskey, Lea Vacca Michel, James L McGrath, Thomas R. Gaborski
Pathogenic bacterial extracellular vesicles (BEVs) can disrupt the blood-brain barrier (BBB), leading to neuroinflammation. Prior in vitro studies of this process were performed in simple models that may have lacked...
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A dual-antibody gold nanoparticle-based lateral flow assay for rapid and selective detection of mesenchymal stem cell stemness

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00037A, Paper

Drishya Prakashan, C. A. Amarnath, Shilpa N. Sawant, G. Taru Sharma, Sonu Gandhi
Smartphone readable AuNPs-LFA enables rapid, visual, and qualitative detection of stemness of MSCs.
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A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01171J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Delaney Gray-Scherr, Terry Ching, Katherine Beran, Sarah C. Adams, Emily Davis, Abraham C. I. van Steen, Trisha Raman, Wilson W. Wong, Jeroen Eyckmans, Christopher S. Chen
A 3D microfluidic platform for studying cross-network transport and trafficking interactions between independently perfusable blood and lymphatic microvascular networks.
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An automated modular microfluidic platform for end-to-end mRNA synthesis and purification

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00118A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Vikas Sharma, Amirreza Mottafegh, Jeong-Un Joo, Dong-Pyo Kim
Manual, batchwise downstream operations remain a major bottleneck in translating microfluidic mRNA synthesis into practical production workflows. Building on an oscillatory microfluidic IVT module (Os(IVT)) previously established for intensified transcription,...
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Flow-Programmable and Reversible Surface-Induced LLPS in Nanofluidic Channels

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00003G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ryoichi Ohta, Zhixin Zhao, Xuan Yan, Ruying Wang, Kazuma Mawatari
Liquid–liquid phase separation (LLPS) functions as a high-performance reactor strategy in cells, creating dynamic "membrane-less organelles" that selectively concentrate biomolecules. Mimicking this volumetric strategy on a chip offers a route...
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Low-temperature inkjet-printed electrochemical sensors on OSTE+ microfluidics for oxygen monitoring and scavenging

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01117E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Denise Marrero, Ferran Pujol-Vila, Eva Tuset, Gemma Gabriel, Rosa Villa, Mar Alvarez, Xavi Illa
Photonic curing sinters gold and silver nanoparticle inks without damaging polymer substrates. Real-time oxygen scavenging is monitored using electrochemical sensors. Tunable oxygen gradients are achieved in OSTE+ microfluidics for OoC models.
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Compact Superlattice as Label-free Surface-Enhanced Raman Scattering Substrate for Noninvasive Urine Test in the Diagnosis of Lung Cancer

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01177A, Paper

Kaili Zhang, Yuancai Ge, Yi Xu, Yujie Liu, Chaoyue Cui, Yuxin Liang, Yangxuan Lin, Jungeng Zhang, Qingwen Zhang, Yi Wang, Xiaoming Lin
The development of noninvasive cancer diagnosis may provide the convenience of remote painless diagnosis, instant healthcare and postoperative follow-up. Label-free surface-enhanced Raman spectroscopy (SERS) is becoming as a powerful approach...
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Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00072J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alison Skelley, Yasna Behmardi, Luke Peterson, David Inglis, Mabel Shehada, Laurissa Ouaguia, Khushroo Gandhi, Roberto Campos-González, Tony Ward
Autologous CAR-T cell therapy has demonstrated remarkable clinical efficacy in hematologic malignancies, yet its broader application remains limited by complex, labor-intensive manufacturing and inconsistent product quality. We describe a novel...
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Stroke volume analog on a chip – in vitro hydrodynamic model of cardiac pumping efficiency

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00547G, Paper

John F. Zimmerman, Luke A. MacQueen, Douglas Henze, Daniel J. Drennan, Sean L. Kim, Herdeline Ann M. Ardoña, Suji Choi, Qianru Jin, Kevin Kit Parker
We demonstrate the use of muscular thin films (MTFs) as a hydrodynamic assay to measure cardiac stroke volume on a chip, and quantify changes in response to ionotropic dosing; helping bridge the gap between in vitro and in vivo measurements.
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PDMS aqueous leachates cause acute toxicity in C. elegans

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00017G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Kin Gomez, Kirill Efimenko, Jan Genzer, Adriana San-Miguel
Leachates from PDMS networks elicit acute toxicity in C. elegans that is strongly shaped by media composition and stress-response pathways. Cholesterol, salts, and transgenerational history determine organismal resilience to PDMS-derived components.
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Rapid desiccation and on-disc rehydration of extracellular vesicles for non-cryogenic preservation

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00014B, Paper

Hyun-Kyung Woo, Sangjin Seo, Advitiya Mahajan, Seoyoung Lee, Seoyoon Bae, Jeremy M. Quintana, Changhyun Kim, Alptekin Aksan, Hakho Lee
AridEx is a centrifugal microfluidic platform for ambient-temperature storage of extracellular vesicles (EVs). This system preserves EV integrity and protein expression, providing a sustainable alternative to −80 °C storage.
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Integration of continuous microfluidic electrokinetic bioparticle preconcentration with programmable extraction into a discrete microfluidic platform

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00647C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Amir Hillman, Sinwook Park, Gilad Yossifon
Ion concentration polarization-based electrokinetic molecular preconcentration in a flowing microchannel, followed by electrowetting-on-dielectric extraction into discrete droplets within an integrated continuous-digital microfluidic platform.
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Multi-wavelength transparent microfluidic device for UV-visible illumination and X-ray scattering studies of photoactive systems

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01116G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Benedetta Marmiroli, Sumea Klokic, Barbara Sartori, Marie Reißenbüchel, Alessio Turchet, Heinz Amenitsch
A microchannel transparent to X-rays in one direction and to UV and visible light in the perpendicular direction allows optimizing illumination for studying structural transitions of liquid samples under photoexcitation.
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Correction: A gut–brain axis on-a-chip platform for drug testing challenged with donepezil

Lab Chip, 2026, 26,2380-2381
DOI: 10.1039/D5LC90130H, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Francesca Fanizza, Simone Perottoni, Lucia Boeri, Francesca Donnaloja, Francesca Negro, Francesca Pugli, Gianluigi Forloni, Carmen Giordano, Diego Albani
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Vertical numbering-up microfluidic architecture for scalable and homogeneous lipid nanoparticle production

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01130B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Zhaoyu Zhang, Jaejeung Kim, Jinwoo Hwang, Hyunjo Seo, Geonha Kim, Seoyeon Choi, Kyung-A Hyun, Hyo-ll Jung
A vertically stacked microfluidic chip enables scalable LNP production while preserving particle quality and therapeutic efficacy.
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Microfluidic determination of minimum miscibility pressure (MMP) in dynamic CO2/n-decane flow

Lab Chip, 2026, 26,2146-2162
DOI: 10.1039/D5LC00616C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Junyi Yang, Peichun Amy Tsai
This work presents a novel microfluidic method for dynamically determining the minimum miscibility pressure (MMP) of CO₂–oil systems with high precision and direct visualization.
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Miniaturisation of Raman spectroscopy systems: from benchtop to backpocket

Lab Chip, 2026, 26,2112-2145
DOI: 10.1039/D5LC00836K, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mike Hardy, Pooja P. Kanade, Emma Buchan, Pola Goldberg Oppenheimer, Cillian P. T. McPolin, Robert M. Bowman
‘Progress of Raman systems from open-bench systems to miniaturised systems.’ Image generated with the assistance of Google Gemini.
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Microfluidic platform for automatic quantification of malaria parasite invasion under physiological flow conditions

Lab Chip, 2026, 26,2250-2265
DOI: 10.1039/D5LC00748H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Emma Kals, Morten Kals, Viola Introini, Boyko Vodenicharski, Jurij Kotar, Julian C. Rayner, Pietro Cicuta
Understanding the impact of forces due to blood flow on biological processes in the circulatory system, such as the invasion of human red blood cells by malaria parasites, is currently limited by the lack of experimental systems that integrate them.
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Intensified lentiviral vector perfusion bioprocessing with a spiral inertial microfluidic cell retention device

Lab Chip, 2026, 26,2368-2379
DOI: 10.1039/D6LC00029K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alexander Bevacqua, Fuguo Liu, Jianzhu Chen, Jongyoon Han
A spiral inertial microfluidic cell retention device enables high-density HEK293 perfusion bioprocessing for intensified lentiviral vector production, yielding functional titers up to 10⁸ TU mL⁻¹ through the device's harvest stream.
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TopoChip-based high-throughput screening of micropatterned hydroxyapatite to guide stem cell behavior and accelerate bone regeneration

Lab Chip, 2026, 26,2201-2217
DOI: 10.1039/D5LC01166C, Paper

Yada Li, Chuanxin Zhong, Mingyu Zhu, Junqin Wang, Qiming Zhuang, Yuqi Tang, Jianfeng Yan, Xiang Ge, Ju Fang, Fuzeng Ren
A hydroxyapatite-coated TopoChip with 127 micropatterns enables high-throughput screening of osteoinductive topographies. Narrow grooves and closely spaced pillars enhance contact guidance, promoting osteogenesis and accelerating bone regeneration.
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An automated microfluidic system based on V-groove chip for rapid immunohistochemistry

Lab Chip, 2026, 26,2228-2236
DOI: 10.1039/D6LC00089D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lu Zhong, Hang Chen, Hong-Lei Chen, Jun Peng, Zhi-Ling Zhang
An automated immunohistochemistry staining system based on a V-shaped upper structure chip enables rapid staining, reducing the processing time from over two hours to just 11 minutes.
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Oscillatory flow for contactless particle trapping

Lab Chip, 2026, 26,2309-2318
DOI: 10.1039/D5LC00813A, Paper

Gabrielle Saint-Girons, Kaustav A. Gopinathan, Sajad Razavi Bazaz, Li Zhan, Jon F. Edd, Mehmet Toner
Oscillatory flow in channels with asymmetry in the flow direction drives particles towards stable 3D attraction regions, enabling contact free trapping.
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Dissociable perfusion chip (DPC): perfusable microfluidic chip for single-cell screening of anti-cancer drugs in live glioblastoma explants

Lab Chip, 2026, 26,2266-2280
DOI: 10.1039/D5LC01105A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Darragh G. Kennedy, Wenting Zhao, Terry L. Chern, Michael Yang, Nicolas Acosta, Siddarth Arumugam, Pavan Upadhyayula, Julia Furnari, Athanassios Dovas, Jeffrey N. Bruce, Peter Canoll, Samuel K. Sia, Peter A. Sims
New approaches are needed to screen anti-cancer drugs that can target specific subpopulations of tumor cells.
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Macroporous transport – mesoporous catalysis: a rapid microfluidic-fabricated biomimetic sponge photocatalytic microsphere reactor

Lab Chip, 2026, 26,2218-2227
DOI: 10.1039/D6LC00078A, Paper

Qikai Wang, Wenwen Shi, Qihang Yang, Feng Teng, Qiuhong Cui
A biomimetic sponge-structured photocatalytic microsphere reactor was batch-fabricated by combining microfluidic technology with confined self-assembly.
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High-throughput single-cell proteomics and transcriptomics from same cells with a nanoliter-scale, spin-transfer approach

Lab Chip, 2026, 26,2319-2329
DOI: 10.1039/D5LC01008J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Pranav Dawar, Lye Meng Markillie, Sarah M. Williams, Hugh D. Mitchell, Johannes W. Bagnoli, Joshua Cantlon-Bruce, Anjali Seth, Carter C. Bracken, Ljiljana Paša-Tolić, Ying Zhu, James M. Fulcher
This work demonstrates a single-cell multiomic technique that directly incorporates high-throughput isobaric LC-MS proteomics with single-cell transcriptomics – accomplished through miniaturized arrays that perform nanoliter-scale droplet transfer.
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High-throughput and efficient fabrication of engineered skeletal muscle tissue via streamlined 3D multimaterial bioprinting

Lab Chip, 2026, 26,2340-2354
DOI: 10.1039/D5LC01040C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tae-Eun Lim, Ashfaq Ahmad, Yeong-Jin Choi, Hee-Gyeong Yi
In this study, we fabricated high-throughput 3D SKM tissues compatible with commercially available 96-well plates using 3D bioprinting.
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Hydrogel microwell with pneumatic soft actuator for compression formation of three-dimensional cellular tissue

Lab Chip, 2026, 26,2173-2186
DOI: 10.1039/D5LC00731C, Paper

Ryota Kawamae, Atsushi Takata, Kenjiro Takemura, Yuta Kurashina
A unique culture system was devised by integrating a pneumatic soft actuator and a hydrogel microwell for cellular tissue formation.
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Dual vision-equipped microfluidic chip for spatiotemporal sequential pick-and-place of oocytes

Lab Chip, 2026, 26,2355-2367
DOI: 10.1039/D5LC01118C, Paper

Open Access

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Shuzhang Liang, Hao Mo, Yuguo Dai, Hirotaka Sugiura, Satoshi Amaya, Fumihito Arai
This study presents a dual vision-equipped microfluidic chip for the manipulation of multiple oocytes between different worksites.
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3D ECM-inflammation model on a microfluidic chip for neutrophil transmigration from whole blood investigations

Lab Chip, 2026, 26,2330-2339
DOI: 10.1039/D5LC00554J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shide Bakhtiari, Vanessa Velasco, Ronald W. Davis
A three-layer microwell with whole blood on top, chemoattractant at the bottom, and extracellular matrix (ECM) in between enables neutrophil migration through the ECM toward chemoattractant in a realistic environment.
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Integrated strategy for breast cancer biomarker analysis using dual ionic liquid aqueous biphasic systems and microfluidic immunoassays

Lab Chip, 2026, 26,2295-2308
DOI: 10.1039/D5LC01010A, Paper

Open Access

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Maria S. M. Mendes, Inês Agostinho, Maria C. Souza, Virginia Chu, Mara G. Freire, Francisca A. e Silva, João P. Conde
Microfluidic HER2 detection is enhanced by a dual ionic liquid aqueous biphasic system that effectively depletes high-abundance proteins.
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Integrated microfluidic platform based on potentiometric Sonogel-Carbon sensors for the simultaneous determination of Na+ and K+ in untreated human plasma and serum

Lab Chip, 2026, 26,2281-2294
DOI: 10.1039/D6LC00117C, Paper

Open Access

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Álvaro Jesús Sainz-Calvo, Álvaro Cordero-Hernández, Marina Jiménez-Rodríguez, Virginia García-Rodríguez, Juan José García-Guzmán, Dolores Bellido-Milla, José María Palacios-Santander, Laura Cubillana-Aguilera
In the present work, two potentiometric sensors for the simultaneous determination of sodium and potassium ions were successfully developed.
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Fast and precise magnetophoresis of superparamagnetic nanoparticles on a micro-magnetic substrate in a static liquid environment

Lab Chip, 2026, 26,2237-2249
DOI: 10.1039/D5LC01072A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Elise Bou, Claudia de la Fuente, Etienne Orsini, Sarah Delshadi, Orphée Cugat, Franz Bruckert
A micro-magnetofluidic chip for fast and collective transport of superparamagnetic nanoparticles over centimetric distances, at velocities reaching up to 1.4 mm s⁻¹, and enabling nucleic acid fluorescence detection by particle accumulation.
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Label-free monitoring of therapy response in 3D spheroids using lab-on-a-chip impedance spectroscopy

Lab Chip, 2026, 26,2163-2172
DOI: 10.1039/D5LC00815H, Paper

Open Access

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Gregory Macke, Maulee Sheth, Manju Sharma, Supasek Kongsomros, Maria Lehn, Trisha M. Wise-Draper, Vinita Takiar, Leyla Esfandiari
The high incidence and mortality of cancer continue to drive research and development of effective therapies. This study uses lab-on-a-chip electrical impedance spectroscopy to evaluate radiotherapy responses in 3D tumor models.
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Acoustic probing of new biomarkers for rapid sickle cell disease screening

Lab Chip, 2026, 26,2187-2200
DOI: 10.1039/D4LC00847B, Paper

Open Access

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Nakul Sridhar, Meiou Song, Michael H. B. Stowell, Kathryn L. Hassell, Xiaoyun Ding
A SAW-integrated microfluidic device enables sickle cell disease screening by acoustic probing of two new biomarkers—RBC lysis temperature and plasma protein precipitation—offering a rapid and low-cost point-of-care blood health assessment.
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Gut-liver-on-a-chip Enables Mechanistic Study and Risk Assessment of Drug-Induced Liver Injury and Drug-Drug Interactions

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01094B, Paper

Yue Yu, Tian Lin, Xiao Ye, Yupeng Wang, Rong-Rong Xiao, Baiyang Sun, Manman Zhao, Jie Song, Bo Li, Xiaobing Zhou
Current preclinical models face challenges in recapitulating organ-level interactions affecting drug safety and there has been little investigation into drug toxicity and related DILI. We presented a pump-less gut-liver-on-chip enabling...
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Size-based sorting of cancer cells reveals functional heterogeneity among subpopulations

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01042J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Esra Yilmaz, Zhimeng Fan, Jason Paul Beech, Vinay Swaminathan, Jonas Olof Tegenfeldt
Cancer cells display marked heterogeneity in size and morphology, traits long recognized in pathology as indicators of pleomorphism and poor prognosis. Yet, the functional significance and phenotypic consequences of these...
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In vitro space of Disse model for exploration of drug induced hepatotoxicity

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01139F, Paper

Open Access

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Ana Mesic, Antonietta Messina, Zoe Tiprez, Benoit Charlot, Safa Mohamed Ismail, Nicolas Huang, Sakina Bensalem, Jean-Charles Duclos-Vallee, Bruno Le Pioufle
A human-cell-derived liver-on-a-chip model integrating tunable alginate hydrogel and LSEC–HepaRG co-culture. Recapitulates sinusoidal architecture, with an emphasis on intercellular communication in the space of Disse.
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Digitally programmable microfluidic valving for autonomous, high-resolution continuous chromatographic purification

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00015K, Paper

Open Access

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Yi-Cheng Liao, Chih-Yi Huang, Yu-Chuan Tang, Cheng-Hsian Wu, Yu-Hsuan Chi, I-Wei Chen, Hsuan-Yu Mu, Ya-Hui Lin, Yunching Chen, Fu-Fei Hsu, Jen-Huang Huang
A programmable, single-use protein purification platform enables contamination-free and continuous workflows for sensitive or variable protein targets through digitally coordinating multistep buffer exchange and time-gated fraction collection.
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Integrated microfluidic platform for inertial separation and encapsulation of single cells in droplets

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00085A, Paper

Fariba Malekpour Galogahi, Haotian Cha, Sharda Yadav, Hang Thu Ta, Nam-Trung Nguyen
This study presents an integrated microfluidic device for simultaneous size-based cell separation and on-chip encapsulation into droplets at single-cell resolution, enabling streamlined processing and efficient downstream single-cell analysis.
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Machine learning-driven single-cell phenotyping in size-controlled microenvironments via parallel deterministic droplet microfluidics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00839E, Paper

Open Access

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Sangmin Lee, Steven O'Donnell, Zhangli Peng, Jae-Won Shin
We present an integrated platform combining deterministic single-cell encapsulation across multiple microgel sizes with machine-learning analysis to identify size-dependent phenotypes and predict microenvironmental confinement.
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Machine learning-augmented lateral flow assays for point-of-care infectious disease diagnostics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01124H, Critical Review

Open Access

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Cagla Parmaksizoglu, Isil Cakiroglu, Nazente Atceken, Eden Morales-Narváez, Ali K. Yetisen, Savas Tasoglu
Advances in LFAs for infectious diseases include nanomaterial engineering, CRISPR amplification, and multiplex designs for better sensitivity and quantitation. AI/ML enables smartphone-based objective analysis, despite standardization challenges, paving the way for connected PoC diagnostics.
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Fluid mechanics of thin blood films to detect anemia and sickle cell disease

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00943J, Paper

Mahrukh A. Mir, Mahesh S. Tirumkudulu, Bhavesh Raicha
We determine the viscosity of blood from the length of blood smears. Viscosity below a threshold indicates anemia, while viscosity increase due to stiffening of red blood cells upon deoxygenation indicates sickle cell disease.
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Tunable squeeze-activated GHz acoustofluidics for stable trapping and separation of sub-100 nm nanoparticles

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00106H, Paper

Yiming Liu, Wei Wei, Hang Qi, Shuaihua Zhang, Yongqi Chen, Yaping Wang, Xuexin Duan
Here we propose a tunable squeeze-activated GHz acoustofluidics (TSGA) platform, which enables continuous enrichment of particles down to 50 nm and high-resolution purification of exosome subpopulations.
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A customizable, low-cost 3D-printed device for live cell confinement imaging

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01146A, Paper

Open Access

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Hunter Richman, Jin Ou, Manpreet Khera, Yan Yu
A 3D-printed, light microscopy-compatible cell confinement device that delivers precise, tunable, and uniform confinement heights while enabling live-cell imaging.
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Monolithic 3D-printed split-and-recombine micromixer integrated into a microfluidic concentration gradient generator

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01095K, Paper

Open Access

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Francisco Navarro Molina, Jitendra Paliwal, Elham Salimi
Monolithic 3D-printed microfluidic device integrating a SAR micromixer and concentration gradient generator, with experimental validation across a broad Reynolds number (Re) range.
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A microfluidic method for controlled generation and trapping of membraneless water-in-water droplets

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01055A, Paper

Open Access

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Chi Li, Hailin Fu, Kalpit J. Bakal, Jaap M. J. den Toonder, E. W. Meijer, Sailing He, Hans M. Wyss
A robust microfluidic platform for liquid–liquid phase separation enables controllable formation, trapping, and reversible compartmentalization of water-in-water droplets in an open system, enabling dynamic studies of multiphase systems.
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Multiphasic droplet microfluidics platform for controlled bacteria and mammalian cell co-culture

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00016A, Paper

Open Access

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Ibraheem Alshareedah, Anand Kumar
Polymer phase separation combined with microfluidics enables the generation of multiphasic droplets for high-throughput mammalian cell–bacteria co-culture.
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Development of a nasal airway-on-chip co-culture model to study particulate matter exposure

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00978B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Amanda C. Walls, Adrienne S. Vaughan, Kartik Balachandran
A nasal airway-on-chip designed for culture of nasal epithelial and endothelial cells in co-culture with the epithelial cells in air–liquid interface culture and exposed to physiological breathing airflows.
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Inkube: an all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange

Lab Chip, 2026, 26,2074-2089
DOI: 10.1039/D5LC00971E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Benedikt Maurer, Selina Fassbind, Tobias Ruff, Jens Duru, Giusy Spacone, Theo Rodde, János Vörös, Stephan J. Ihle
A compact open-source platform merging cell culturing, electrophysiology, and automated perfusion, which provides robust environmental control and continuous recording/stimulation.
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Vascularizing organoids-on-chip for perfused and personalized models

Lab Chip, 2026, 26,1798-1819
DOI: 10.1039/D5LC00890E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Bianca Menzani, Priscille De Gea, Xavier Gidrol, Emily Tubbs
This review discusses the current strategies and technical considerations for vascularizing organoids-on-chip, highlighting their potential to improve physiological relevance, functional performance, personalization and translational applicability.
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On-chip acoustic chaotic micromixer for point-of-care applications

Lab Chip, 2026, 26,2090-2099
DOI: 10.1039/D5LC01183C, Paper

Xian Chen, Chuanchao Zhang, Yaping Wang, Xuexin Duan, Yunhua Gao
We proposed an acoustofluidic platform actuated by the Lamb wave resonator array, which facilitates sample pretreatment, chaotic mixing, analyte trapping and detection on a single chip for the truly “sample-in-answer-out” point-of-care detection.
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A portable, low-cost, point-of-care DNA amplification kit with impedance-based detection for decentralized antimicrobial resistance diagnostics

Lab Chip, 2026, 26,2061-2073
DOI: 10.1039/D6LC00062B, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Koosha Karimi, Miriam Arroyo, Erin E. Chille, Timothy G. Stephens, Donal Barrett, Vicent Pelechano, Debashish Bhattacharya, Mehdi Javanmard
This study presents a low-cost, portable DNA amplification kit that performs modified LAMP to produce DNA nanoballs, integrated with a microfluidic impedance-based digital assay to enable an all-in-one, point-of-care nucleic acid diagnostic platform.
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Correction: Reversible and reusable compartmentalized thermoplastic chip for coculture of dorsal root ganglion neurons

Lab Chip, 2026, 26,2100-2100
DOI: 10.1039/D5LC90129D, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Solène Moreau, Raul Flores-Berdines, Anne Simon, Tatiana El Jalkh, Guillaume Taret, Anna Fomina, Céline Dargenet-Becker, André Estevez-Torres, Sophie Bernard, Hugo Salmon
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Intelligent image-activated sorting of large cells enabled by elasto-inertial focusing

Lab Chip, 2026, 26,2047-2060
DOI: 10.1039/D5LC01143D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yuzuki Nagasaka, Akihiro Isozaki, Hiroki Matsumura, Natsumi Tiffany Ishii, Norah Roels, Mina Rassuli, Kelvin C. M. Lee, Walker Peterson, Tianben Ding, Keisuke Goda
We integrated a long, straight, elasto-inertial focuser into an intelligent image-activated cell sorter, enabling the sorting of large objects based on content-rich image analysis by deep learning while maintaining high event rates.
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WAFFLE – an automated platform for enhancing the performance of electrochemical biosensors

Lab Chip, 2026, 26,2035-2046
DOI: 10.1039/D5LC00988J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alexandra Dobrea, Rowan Blake, Daniel Macdonald, Cormack McKenzie, Yoann Altmann, Damion K. Corrigan, Melanie Jimenez
We introduce the WAFFLE – a fully automated, open-source platform combining sensor fabrication and MCMC-based analysis for enhanced electrochemical biosensing.
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Bone-on-leaf-chip for the study of lung cancer bone metastasis

Lab Chip, 2026, 26,1996-2011
DOI: 10.1039/D5LC00951K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Qi Liu, Di Suo, Renxian Wang, Shuai Zhao, Mao Mao, Wei-Ning Lee, Yuhe Yang, Xin Zhao
A leaf vein chip was developed for simulating the actual process of lung cancer bone metastasis through a multi-scale vascular structure.
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Two-phase simulations of viscoplastic flow in superhydrophobic microchannels: interface stability, plug dynamics, and drag reduction

Lab Chip, 2026, 26,1958-1979
DOI: 10.1039/D5LC01099C, Paper

Amir Joulaei, Hossein Rahmani, Seyed Mohammad Taghavi
Viscoplastic flow over superhydrophobic grooves exhibits regimes of interface pinning, depinning, and plug breakage governed by inertia, capillarity, and yield stress, enabling a predictive design map to optimize lab-on-a-chip devices.
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High-throughput label-free assessment of sperm DNA fragmentation index via intelligent morphological imaging

Lab Chip, 2026, 26,2012-2022
DOI: 10.1039/D5LC01122A, Paper

Yan Jin, Yujie Zou, Yueyun Weng, Zhaoyi Ye, Xiaoyang Chen, Zhengwu Liu, Tailang Yin, Sheng Liu, Yan Zhang, Cheng Lei
Intelligent morphological imaging flow cytometry is developed for high-throughput label-free sperm DNA fragmentation index assessment.
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A wearable 3D-printed hollow microneedle device for pressure-driven interstitial fluid collection and testing

Lab Chip, 2026, 26,1943-1957
DOI: 10.1039/D5LC00657K, Paper

Nedim Hacıosmanoğlu, Emre Ece, Fatih Inci
μHolloSense, a novel 3D printed hollow microneedle (MN) device with integrated suction and test ports for the extraction and testing skin interstitial fluid (ISF).
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Muscle regeneration on a chip: exercise-induced microtrauma and optimal mechanical stimulation regimen

Lab Chip, 2026, 26,1980-1995
DOI: 10.1039/D5LC00513B, Paper

Hongze Yin, Juan Zhang, Jing Zhou, Hui ying Yang, Jiahao Wang, Yue Wang, Na Liu, Tao Yue
In this study, we developed a simplified microfluidic chip system based on flexible PDMS films to construct a multi-layer configuration, which was utilized to establish an in vitro model of muscle mechanical behavior for simulating muscle injury and repair during exercise.
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Microfluidic NMR for operando monitoring of drug-induced metabolic fluxes in liver tissue slices

Lab Chip, 2026, 26,2023-2034
DOI: 10.1039/D5LC00819K, Paper

Sylwia J. Barker, Bishnubrata Patra, Manvendra Sharma, Annamarija Raic, Ruby E. H. Karsten, Elisabeth Verpoorte, Marcel Utz
Monitoring metabolism in living tissues with high temporal resolution and broad metabolite coverage through microfluidic NMR.
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A smart 3D microfluidic tumor spheroid-vessel co-culture model for studying exosomal HSP-mediated tumor invasion and angiogenesis

Lab Chip, 2026, 26,1820-1829
DOI: 10.1039/D5LC00857C, Communication

Open Access

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Sisi Zhou, Fanshu Shan, Yue Zhang, Yu Cao, Junhui Cen, Noritada Kaji, Songqin Liu
We developed a microfluidic 3D co-culture system integrating tumor spheroids, endothelial cells, and matrix to model metastasis, enabling real-time monitoring of invasion and angiogenesis via ZEB1/CD31 staining.
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Nanofluidic-based electrochemical pump for remotely controlled, on-demand drug delivery

Lab Chip, 2026, 26,1874-1889
DOI: 10.1039/D5LC00708A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Marco M. Paci, Nicola Di Trani, Paolo Bolla, Fabiana Del Bono, Takuma Yoshikawa, Isaac Tichy, Patrick S. Stayton, Alessandro Grattoni
A nanofluidic electrochemical pump uses in situ gas generation to modulate pressure and enable remotely controlled, on-demand drug release across diverse molecules.
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Systematic characterization and mechanistic insights into ultrasonically actuated sharp-tip capillary droplet generation

Lab Chip, 2026, 26,1930-1942
DOI: 10.1039/D5LC00954E, Paper

Qi Zhang, Li Ran, Gang Li
Ultrasonically driven sharp-tip capillary generates droplets without chips or pumps. A three-stage pinch-off mechanism has been elucidated, enabling the production of programmable multi-volume droplet trains within a single stream.
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Label-free assessment of a microfluidic vessel-on-chip model with visible-light optical tomography reveals structural changes in vascular networks

Lab Chip, 2026, 26,1901-1914
DOI: 10.1039/D5LC00927H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Devin Veerman, Carlos Cuartas-Vélez, Tarek Gensheimer, Tomas van Dorp, Andries van der Meer, Nienke Bosschaart
Optical coherence tomography is a label-free imaging technique that can provide structural readouts in a vessel-on-chip.
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MyeliMAP: a microfluidic-multielectrode array hybrid platform to investigate oligodendrocyte function in human iPSC derived brain-like networks

Lab Chip, 2026, 26,1915-1929
DOI: 10.1039/D5LC01062D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Karan Ahuja, Blandine F. Clément, Giulia Amos, Joël Küchler, Keimpe Wierda, Yoke Chin Chai, Lieve Moons, Catherine Verfaillie
MyeliMAP, a human iPSC-based myelination platform integrating microfluidics and high-density electrophysiology enables functional assessment of axonal conduction and myelin-dependent signal propagation.
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Controlling spatial structure in minimal microbial communities by sequential capillary assembly

Lab Chip, 2026, 26,1861-1873
DOI: 10.1039/D6LC00040A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Cameron Boggon, Jeremy P. H. Wong, Arpita Sahoo, Annelies S. Zinkernagel, Markus A. Seeger, Eleonora Secchi, Lucio Isa
Controlled patterning of microparticles with specific binding allows building two-species bacterial communities with defined spatial structures.
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A high-throughput liver-kidney metabolic interaction chip for insights into the nephrotoxicity mechanisms of triptolide

Lab Chip, 2026, 26,1830-1849
DOI: 10.1039/D5LC01051A, Paper

Siyu Liu, Yun Yang, Yifei Yang, Guangfei Wei, Liu Zhou, Jiawei Lin, Zheng Yuan, Yingfei Li, Zhe Wu, Ting Liu, Guozhuang Zhang
The high-throughput liver-kidney metabolic interaction chip is a powerful tool for studying drug-induced nephrotoxicity and the underlying mechanisms.
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An active-matrix digital microfluidic device based on surfactant-mediated electro-dewetting

Lab Chip, 2026, 26,1850-1860
DOI: 10.1039/D5LC00992H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xinying Xie, Qining Leo Wang, Runxiao Shi, Tengteng Lei, Chang-Jin “CJ” Kim, Man Wong
A surfactant-mediated electro-dewetting digital microfluidics device features a 4T2C circuit for low-voltage active-matrix driving.
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Size-based sorting of dynamic bacterial clusters

Lab Chip, 2026, 26,1890-1900
DOI: 10.1039/D5LC01111F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Elham Akbari, Jason P. Beech, Johannes Kumra Ahnlide, Sebastian Wrighton, Pontus Nordenfelt, Jonas O. Tegenfeldt
Group A Streptococcus (GAS) forms highly deformable aggregates with broad variations in size and morphology, complicating controlled separation and biological analysis.
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