RSC - Lab Chip latest articles

Deterministic radial displacement: modular, reconfigurable, and reusable

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00348F, Paper

Sean C. McCabe, Shilun Feng, David W. Inglis
By cylindrically revolving a DLD array, devices can be fabricated in segments and simply assembled, delivery modularity and reusability.
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Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00957J, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ty Naquin, Chloe Naquin, Qian Wu, Ying Chen, Aidan Canning, Kaichun Yang, Yuna Li, Shuaiguo Zhao, Yun Ling, Zhiteng Ma, Ke Jin, Ye He, Shujie Yang, Luke P. Lee, Tony Jun Huang
Integrated microfluidic biosensors have rapidly evolved into powerful platforms to meet the increasing demand for ultrasensitive and high-throughput quantitative analysis.
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Tunable Self-Assembling Cellular Microarray for Single-Neutrophil Vital and Suicidal Extracellular Traps

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D5LC01156F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jacob Doon-Ralls, Sophia Mayone, Xilal Y. Rima, Dharti Shantaram, Kim Truc Nguyen, Ajeet Singh, Bradley J. Needleman, Sabrena Noria, Stacy Brethauer, Kyle A. Perry, David Wood, Anahita D. Jalilvand, Willa A. Hsueh, Eduardo Reátegui
Neutrophils, the innate immune system's first line of defense, function in pathogen removal through diverse cellular responses. One critical response is neutrophil extracellular trap (NET) formation, which, despite its importance...
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Capillary flow-driven paper-based microfluidic sensor for NDMA detection in water

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00165C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Prakash Aryal, Jade Manna-Rubenstein, Tessa Whitaker, Eric Brack, Charles S. Henry
Detection of N-nitrosodimethylamine (NDMA) via on-chip photonitrosation followed by dual colorimetric detection using two complementary metal complexation systems.
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A quantitative rapid test for urine creatinine via Fenton's reaction and a self-driven microfluidic device

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00249H, Paper

Hogi Hartanto, Jiaheng Li, Cheuk Chun Szeto, Ting-Hsuan Chen
A self-driven microfluidic chip converting urine creatinine into a length of a visual bar using creatinine's inhibition to Fenton's reaction, achieving limit of detection of 20.11 mg dL⁻¹ and high compatibility with clinical urine samples.
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Modular microfluidic probe for addressable fluidic landscapes

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00133E, Paper

Ayoub Glia, Muhammedin Deliorman, Mohammad A. Qasaimeh
Plug-and-play IPOF microfluidics converts open-space flows into addressable chemical nodes for programmable reagent delivery, gradient discretization, and multiplexed surface patterning.
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Auto-SELEX: a fully automated microfluidic platform for rapid discovery of high-affinity aptamers

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00275G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yang Bu, Yuze Liu, Anni Hu, Yung Ching Lee, Levent Yobas
A fully automated microfluidic SELEX that accelerates weeks-long aptamer discovery to 30 min selection rounds by integrating free-solution electrokinetic partitioning through an artificial sieve with plasmonic bead-based PCR using Au nanorods.
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Traumatic brain injury on-a-chip: a microfluidic device for the compression of cortical spheroids

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00058D, Paper

Mauricio David Araiza Canizales, Alexander McGhee, Yang Wan, Jing Zhang, Emily Blick, Rafael D González-Cruz, Diane Hoffman-Kim, Haneesh Kesari, Christian Franck
Traumatic brain injury (TBI) affects more than 4.6 million people annually in the United States, with the true numbers of mild TBI (mTBI) likely much higher due to insufficient detection...
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A dual-mode vertical flow assay for species-specific identification and total bacteria load assessment from a single urine sample

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00265J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shu-Yun Sheu, Ching-Fen Shen, Chao-Min Cheng
Rapid urine screening would benefit from simultaneous determination of pathogen identity and clinically relevant bacteria burden, yet most paper-based assays provide only one of these outputs. Here, we report on...
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Learning-aided design of micropost arrays for optimizing interface stability and mass transport in organs-on-chips

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01180A, Paper

Daeho Kim, Suhwan Lee, Suyeon Kim, Yoojeong Noh, Eunseop Yeom, Song Ih Ahn
We use simulation-guided multi-objective optimization of micropost geometry to stabilize hydrogel interfaces while balancing mass transport and interface stability.
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3D stamp-integrated open-top microfluidic organ-on-a-chip for high-fidelity and functional reconstruction of vascularized microtissue models

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00096G, Paper

Chenyang Zhou, Feifan Wang, Jiaqi Xu, Aochen Wang, Hanping Song, Luyao Wei, Guoxiang Fu, Xiaolin Wang
A open-top microfluidic organ-on-a-chip that integrates stamp-based patterning with sequential cellular assembly to achieve simultaneous construction of organ-specific topological architectures and perfusable vascular networks.
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Acoustofluidic separation of oblate spheroids from spheres using acoustic radiation torque and force

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00140H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Muhammad Soban Khan, Mushtaq Ali, Yong Bin Bang, Seong Jae Lee, Jinsoo Park
We propose label-free acoustofluidic separation of oblate spheroids from spheres using traveling surface acoustic wave-induced radiation torque and force, achieving high-purity, high-recovery separation of polymer microparticles and red blood cells.
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A microfluidic dermal fibroblast–macrophage co-culture on a chip linking inflammatory signalling to barrier-associated function

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00175K, Paper

Preeda Larpthavee, Thitikorn Chomthong, Pareesa Pormrungruang, Suvimol Surassmo, Sakon Rahong
Immune-responsive microfluidics integrates dermal fibroblast–macrophage co-culture in 3D collagen to model inflammation. LPS induces NO/TNF-α responses, while nanocarriers suppress inflammation and restore ECM, enabling fast, animal-free drug screening.
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DROP-LCMS for wastewater surveillance of viral disease

Lab Chip, 2026, 26,3013-3019
DOI: 10.1039/D6LC00131A, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jiaxi Peng, Vigneshwar Rajesh, Jiarui Shen, Jianxian Sun, Calvin Chan, Yechen Hu, Hui Peng, Aaron R. Wheeler
A new microfluidic technique, DROP-LCMS, is introduced for semi-automated processing of wastewater samples for surveillance of viral disease.
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Predicting human pharmacokinetic parameters of drugs using a multi-tissue chip platform integrating liver, kidney, and skeletal muscle microphysiological systems

Lab Chip, 2026, 26,3054-3068
DOI: 10.1039/D6LC00008H, Paper

Jason Sherfey, Shiny Amala Priya Rajan, Lauren M. Nichols, Paarth Parekh, J. Tyler Smith, Lauren Gregory, Frances Clark, Eugene P. Kadar, Shivam Ohri, Billy T. George, David Tess, James R. Gosset, Jennifer Liras, Emily Geishecker, R. Scott Obach, Murat Cirit
A combinatorial NAM approach integrating multi-tissue chip with QSP modeling enables accurate prediction of human exposure for hepatically and renally cleared small molecules.
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A combinatorial screening platform for in situ gene delivery to adherent cells via digital microfluidics and flexible electrodes

Lab Chip, 2026, 26,3256-3269
DOI: 10.1039/D6LC00124F, Paper

Yi Weng, Xiangyu Ren, Fuqiang Guo, Weichao Wu, Bin Wang, Chaobo Li
The PDES platform solves the bottlenecks of traditional electroporation methods: manual operation, high reagent use, and low throughput. The micro-level automated reaction system allows multidimensional orthogonal screening and fast optimization of electrical parameters and biological components.
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Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles

Lab Chip, 2026, 26,3039-3053
DOI: 10.1039/D6LC00098C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Wenyang Jing, Heewon Noh, Timothy J. C. Tan, Nicholas C. Wu, Hee-Sun Han
Decoding dewetting dynamics in double emulsions establishes predictive rules for robust, tunable GUV assembly. This physics-based framework provides systematic guidance to optimize GUV production across varied lipid, aqueous, and fluidic parameters.
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Estimating single-cell elastic modulus in a serial microfluidic cytometer from time-of-flight and fluorescence signals analysis

Lab Chip, 2026, 26,3168-3183
DOI: 10.1039/D5LC00930H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Graylen R. Chickering, Leroy L. Jia, Matthew DiSalvo, Megan A. Catterton, Paul N. Patrone, Eric M. Darling, Gregory A. Cooksey
Particles can migrate in flow based on size and deformability, resulting in measurable time-of-flight differences. These same mechanical properties can reflect changes in cellular state, function, and disease.
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Centrifuge-free separation of plasma from milliliters of whole blood for point-of-care diagnostics

Lab Chip, 2026, 26,3139-3152
DOI: 10.1039/D6LC00135A, Paper

Open Access

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Christia M. Victoriano, Bianca Arraiza Carlo, Abigail G. Ayers, Kelia A. Human, Samuel K. Sia
PlasmaLIFT enables automated plasma separation from milliliters of whole blood by integrating immunomagnetic red blood cell depletion with dual-membrane filtration.
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Stretchable mesoporous electrodes as a versatile platform for minimally invasive surgical devices

Lab Chip, 2026, 26,3069-3082
DOI: 10.1039/D6LC00110F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Michael Abraham Listyawan, Chi Cong Nguyen, Tran Bach Dang, Nhat Mihn Doan, Quang Anh Nguyen, Yulin Qiu, Eva Tomaskovic-Crook, Mostafa Kamal Masud, Yusuke Yamauchi, Jeremy Micah Crook, Mohit Naresh Shivdasani, Thanh Nho Do, Hoang-Phuong Phan
A scalable fabrication strategy to integrate thin, stretchable mesoporous electrodes onto catheters and soft robotic systems, enabling multifunctionalities including biopotential measurement, electrical stimulation, and bioimpedance sensing.
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A microfluidic skin-on-a-chip enabling in situ construction of full-thickness human skin for modeling inflammatory diseases

Lab Chip, 2026, 26,3192-3201
DOI: 10.1039/D6LC00189K, Paper

Linwei Sang, Ajing Liu, Junjie Zhu, Qian Yang, Zheng Liu, Shu-Wei Chen, Jinyi Wang
This study presents a detachable microfluidic skin-on-a-chip. Using epidermal–dermal co-culture under dynamic perfusion, the chip enables on-chip construction of inflammatory phenotype and drug evaluation.
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Porous microneedle-based electrochemical aptamer biosensor for the collection and quantitative analysis of dry eye disease biomarkers

Lab Chip, 2026, 26,3002-3012
DOI: 10.1039/D6LC00230G, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Eira Beryle Ko, Tianli Hu, Ya Zhang, Xueyan Wang, Yu Song, Chenjie Xu
A porous microneedle-integrated electrochemical aptamer sensor allows for the rapid tear extraction and quantitative biomarker detection in a single device for dry eye disease.
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Selective on-chip DNA synthesis using electric field-assisted PCR

Lab Chip, 2026, 26,3202-3212
DOI: 10.1039/D5LC01200G, Paper

Doyeon Lim, Youngjun Song
An electric field-assisted PCR platform enables selective on-chip DNA synthesis with precise spatial control using microelectrode arrays. This scalable approach achieves high-efficiency enzymatic synthesis for DNA data storage and diagnostics.
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LEGO®-inspired electrically-actuated microfluidics for on-chip protein crystallization and in situ X-ray crystallography

Lab Chip, 2026, 26,3213-3228
DOI: 10.1039/D6LC00021E, Paper

Sarthak Saha, Logan Chen, Gabrielle R. Budziszewski, Sara Koprek, Kaleb Seifert, Aina Cohen, Silvia Russi, Sarah E. J. Bowman, Sarah L. Perry
Low-voltage valve actuation to facilitate protein crystallization and in situ X-ray structure determination.
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Microfluidic well plates integrated with passive nematode culture chambers for multiplexed chemical toxicity assays in C. elegans

Lab Chip, 2026, 26,3083-3101
DOI: 10.1039/D5LC01165E, Paper

Bushra Rahman, Purushottam Soni, Atiyya P. Saroyia, William Schenkenfelder, Siva A. Vanapalli
PNC well plates enable low-intervention, multiplexable C. elegans assays with translational potential for predictive toxicology.
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Region-specific proteomic profiling of brain interstitial fluid via a micro-invasive sampling platform

Lab Chip, 2026, 26,3153-3167
DOI: 10.1039/D6LC00038J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Qun Cao, Hannah D. Jackson, Aidan J. Duncan, Yufei Cui, Haley O. Higginbotham, Stella Lesnik, Yunseo Jo, Jiaquan Yu, Forest M. White, Michael J. Cima
This study presents a localized, membrane-free method for sampling brain interstitial fluid, enabling high protein yield from small volumes. It uncovers proteomic differences across brain regions, supporting improved biomarker detection.
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A tunable 50 MHz acoustic vortex tweezer for size-selective manipulation and cell pre-concentration

Lab Chip, 2026, 26,3184-3191
DOI: 10.1039/D6LC00010J, Paper

Xiongwei Wei, Xin Wang, Lili Miao, Yi Quan, Chunlong Fei, Yintang Yang
A tunable 50 MHz silicon metasurface vortex tweezer with M = 1, 3, 5 adjusts capture orbit (50–150 μm), enabling orbital rotation, size-selective manipulation and cell pre-concentration.
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A compact low-power valveless piezoelectric micropump with a nested rectification structure

Lab Chip, 2026, 26,3128-3138
DOI: 10.1039/D6LC00060F, Paper

Jie Shan, Aoyu Ma, Cuixue Ren, Yuren Zhao, Lixia Yang, Jingmin Li
A valveless piezoelectric micropump with a novel nested rectification structure achieves high net flow rate and low power consumption in a compact design. It shows promising potential for microfluidic chip systems and biofluid transport.
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Topology-based coordination control for multi-droplet tasks in autonomous digital microfluidics

Lab Chip, 2026, 26,3244-3255
DOI: 10.1039/D6LC00147E, Paper

Kunlun Guo, Zerui Song, Boyi Feng, Tiaofen Qiu, Jiale Zhou, Bin Shen, Bingyong Yan, Zhen Gu, Huifeng Wang
An unmanned topology-based digital microfluidics control system is developed that integrates adaptive path planning with semantic segmentation feedback to achieve fully autonomous coordination of multi-unit droplets with dynamic morphologies.
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High-throughput microfluidic platform for modelling inflammatory responses of human articular chondrocytes under variable fluid shear stress

Lab Chip, 2026, 26,3112-3127
DOI: 10.1039/D5LC01167A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Aldeliane M. da Silva, Priscila Campioni Rodrigues, Meriem Lamghari, Hoang-Tuan Nguyen, Jere Kettunen, Sebastien Mosser, Prateek Singh, Ali Mobasheri, Gabriela S. Lorite
A scalable, pumpless microfluidic platform applies shear stress gradients and cytokine-driven inflammation to model osteoarthritis physiologically.
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A compact superlattice as a label-free surface-enhanced Raman scattering substrate for noninvasive urine testing for the diagnosis of lung cancer

Lab Chip, 2026, 26,3102-3111
DOI: 10.1039/D5LC01177A, Paper

Kaili Zhang, Yuancai Ge, Yi Xu, Yujie Liu, Chaoyue Cui, Yuxin Liang, Yangxuan Lin, Jungeng Zhang, Qingwen Zhang, Yi Wang, Xiaoming Lin
A self-assembled compact superlattice is fabricated as a surface-enhanced Raman spectroscopy substrate to distinguish between urine samples from lung cancer patients, post-operative patients, and healthy persons with high accuracy and efficiency.
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Numerical microfluidic chip modeling of laminar vortex dynamics induced by biomineralization in evolving porous media

Lab Chip, 2026, 26,3020-3038
DOI: 10.1039/D5LC01002K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yajie Chu, Dianlei Feng
A 3D numerical microfluidic chip reveals the evolution of precipitation, vortices, and mixing during biomineralization. Precipitate alters pore geometry, inducing vortices that impact mixing.
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Cell therapy manufacturing at full clinical scale: enhancing the quality CAR-T cell therapy starting materials through massively parallel automated microfluidic cell sorting

Lab Chip, 2026, 26,3229-3243
DOI: 10.1039/D6LC00072J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Alison M. Skelley, Yasna Behmardi, Luke F. Peterson, David W. Inglis, Mabel Shehada, Laurissa Ouaguia, Khushroo Gandhi, Roberto Campos-González, Tony Ward
Over N = 86 full scale apheresis samples, microfluidic DLD processing yielded significantly higher leukocyte recovery (88% vs. 58%), superior platelet and red blood cell depletion, and reduced CD69⁺ T cell activation compared to conventional Ficoll®.
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Point of care molecular cancer diagnostics

Lab Chip, 2026, 26,2948-3001
DOI: 10.1039/D5LC01014D, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Seemesh Bhaskar, Saurabh Umrao, Han Keun Lee, Joseph Tibbs, Amanda Bacon, Skye Shepherd, Takhmina Ayupova, Fatma Uysal Ciloglu, Leyang Liu, Anqi Tan, Wang-Chien Chen, My Thi Tra Nguyen, Maria Grace Scannell, Ugur Aygun, Ugur Parlatan, Catherine Zhang, Manish Kohli, Guy R. Adami, Wali Badar, Ron C. Gaba, Aaron Mansfield, Joel Schwartz, Wang Xing, Utkan Demirci, Brian T. Cunningham
Convergent framework for future POC cancer diagnostics aligning clinical needs (why), enabling technologies (how), and translational bridges. It integrates lab-on-chip biosensing and analytics for decentralized, early, longitudinal care.
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Vacuum-enhanced high-resolution 3D printing yields 11 200 valves and uniform 7 μm isoporous membranes

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00100A, Paper

Dallin S. Miner, Timothy B. Skaggs, Barrett W. Schafer, Heidi E. Hunter, Troy Munro, Adam T. Woolley, Gregory P. Nordin
Vacuum-enhanced high-resolution 3D printing enables scalable, high-density microfluidic fabrication, as demonstrated by the reliable production of 11 200 membrane valves and 198 uniform 7 μm isoporous membranes across the full print area.
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Local chemotactic response of Escherichia coli in fluid and near surfaces

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01048A, Paper

Open Access

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Adam Gargasson, Julien Bouvard, Carine Douarche, Peter Mergaert, Harold Auradou
Bacteria can adjust their swimming behaviour in response to chemical variations, a phenomenon known as chemotaxis. Their chemotactic sensibility is logarithmic, and greatly reduced on surfaces.
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A microfluidic approach to evaluating surface protection from nonspecific antibody adsorption

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00197A, Paper

Open Access

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Yulia Tobolovskaya, Bexi M. Bustillo-Perez, Yingshan Ma, Nadine Löw, Ophélie Zeyons, Daniel A. Richards, Eugenia Kumacheva
A fluorescence assay-based microfluidic approach for real-time studies of the surface adsorption of antibodies and high-throughput screening of anti-biofouling compounds.
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Microfluidic insights into microbial impacts on hydrogen flow in underground hydrogen storage

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00206D, Paper

Yuyi Liu, Diansen Yang
Underground hydrogen storage, involving periodic injection and extraction of hydrogen gas, serves as a crucial approach for achieving energy peak shaving and accommodating large-scale renewable energy.
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A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00143B, Paper

Open Access

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Avi Gupta, Jacqueline Van Zyl, Collin Bushey, Peter Shankles, Hoseyn A. Amiri, Guillem Pratx, Alexander Alexeev, Todd Sulchek
Narrow, parallelized channels reveal a dynamic loading regime that, when integrated with geometry, flow, single-cell kinematics, and delivery outcomes, defines a mechanistic framework for microfluidic mechanoporation.
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Exploring paclitaxel–albumin-loaded neutrophil-like cells via microfluidic-based mechanical deformation for enhanced cargo delivery in glioblastoma therapy

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01140J, Paper

Daidi Zhou, Xinghua Gao, Zhiyu Mao, Xiaoling Yang, Jingyun Ma, Ekaterina Andreevna Vorotelyak, Guohui Hu, Fengping Zhu, Jinbo Wu
This study investigated the rapid drug delivery capabilities of neutrophil-like cells using a microfluidic chip-based mechanical deformation approach, with an emphasis on glioblastoma treatment at the cellular level.
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High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01050K, Paper

Open Access

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Alexander Bevacqua, Do Hyun Park, Sheryar Khan, Qingxuan Li, Mahsa Hadidi, Jianzhu Chen, Jongyoon Han
A 25-layer spiral microfluidic device significantly reduces cell biomass from high-turbidity feedstock using inertial focusing to perform primary clarification and harvest adeno-associated virus (AAV) vectors at 20 mL min⁻¹ with 85% vector recovery.
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3D printing monolithic, multifunctional polymer acoustofluidic devices with tunable mixing and particle focusing

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00107F, Paper

Open Access

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Roxanne Kate Balanay, Justin W. Yip, Justin Do, Omair Adil, Keith Johnson, Tyler R. Ray
Acoustic forces offer a powerful, contact-free modality for manipulating particles and fluids within microfluidic lab-on-a-chip systems.
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Experimental diffusiophoresis of porous and non-porous silica particles in dead-end pore microchannel geometry

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01020A, Paper

Open Access

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Mansoureh Rashidi, Matina Nooryani, Giovanniantonio Natale, Anne M. Benneker
The movement of colloids in a solute concentration gradient plays a crucial role in applications, including separations, sorting and reactant transport. We show that porous particles respond different to solute gradients than solid particles.
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Creating an improved workflow for paper-based malaria diagnostics by integrating total lysis of whole blood

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00145A, Paper

Open Access

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J. Prat-Trunas, A. Code, Y. Avalos-Padilla, X. Fernández-Busquets, C. R. Mace, E. Baldrich
Three-dimensional paper-based lysis device fabricated by laser cutting or by wax printing that achieves 100% cellular lysis independent of sample composition, facilitating detection of a malaria biomarker and sample storage for 1 week at RT.
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Droplet microfluidic profiling of NK cell cytotoxicity with machine learning-enabled target-cell death analysis

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00301J, Paper

Open Access

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Rana S. Ozcan, Fatemeh Vahedi, Shina Namakian, Ali A. Ashkar, Tohid F. Didar
A droplet microfluidic workflow combines ML-based K562 death analysis with manual NK annotation to quantify attachment, killing, serial killing, and killing-time differences across primary, expanded, and tumor-conditioned NK cells.
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Development of a 16-channel solid-state nanopore array platform for integrated nanopore fabrication and ionic current measurement

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00216A, Paper

Open Access

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Itaru Yanagi, Tadashi Kiyuna, Keiko Esashika, Yoshimitsu Yanagawa, Hai Huy Nguyen Pham, Daiki Kawai, Satoshi Ogihara, Gaku Ogino, Ken-ichi Takeda, Sotaro Uemura
A 16-channel solid-state nanopore array platform enables integrated nanopore fabrication and parallel ionic current measurement.
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Highly sensitive wireless dual-spiral resonant contact lens for continuous intraocular pressure monitoring

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00940E, Paper

Ying Liu, Zhixian Chen, Xiaoyu Zhao, Lin Xu, Shengli Mi
A highly sensitive wireless contact lens featuring an axisymmetric dual-spiral resonator enables continuous, non-invasive intraocular pressure monitoring for glaucoma management.
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Point-of-care SERS platforms: integrating microfluidics and machine learning for disease screening

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00202A, Critical Review

Biqing Chen, Xiaohong Qiu, Yang Li
Microfluidic SERS platforms enable ultrasensitive, high-throughput bioanalysis via Raman enhancement and microfluidic control. Plasmonic integration supports multiplexed biomarker detection for biomedical research and clinical translation.
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Yield stress fluids in microfluidics: research, applications and opportunities

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00864F, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Hossein Rahmani, Seyed Mohammad Taghavi
Microfluidic technologies support diverse biomedical and environmental applications, many of which involve complex fluids whose non-Newtonian rheology governs small-scale transport, mixing, and interfacial dynamics.
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Microfluidic profiling of suspension cell–metal adhesion at single-cell resolution under flow

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01090J, Paper

Eunyoung Park, Seungjin Kang, Jieung Oh, Sangwoo Kim, Ung Hyun Ko
High-throughput quantification of cell–metal adhesion using single-cell transit velocity measurements in a microfluidic channel.
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Multiplexed nanophotonic biosensing and deep learning-driven protein quantification for traumatic brain injury diagnosis at the point of care

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01079A, Paper

Jiayu Liu, Yuxin Wang, Shichao Su, Meng Su, Wenying Lv, Zhao Gao, Congwei Liu, Yanteng Li, Junzhao Sun, Peng Wang, Baorui Guo, Fan Yang, Renke He, Yanlin Song, Zeying Zhang, Jianning Zhang, Gang Cheng
This integrated nanophotonic biosensor platform enables multiplex detection of TBI biomarkers through an end-to-end process, offering a rapid, ultrasensitive, and field-deployable solution for acute brain injury diagnostics.
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A portable modular acoustic streaming vortex platform for flexible and robust fabrication of monodisperse micromaterials

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00054A, Paper

Xiaoping Miao, Tianao Chen, Jijie Fu, Shilu Zhu, Mei Lan, Huayi Fu, Zhiqiang Zhu, Mingzhai Sun, Ronald X. Xu
A modular acoustic streaming vortex (MASV) platform has been developed for off-chip production of monodisperse microdroplets with broad size tunability and versatile viscoelastic properties.
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Thin stencil membrane-assisted high throughput single-cell to cluster of cells micropatterning and large-size biomolecular transfection in primary and stem cells

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00164E, Paper

Donia Dominic, Srabani Kar, Rajdeep Ojha, Moeto Nagai, Tuhin Subhra Santra
Schematic illustration of high-throughput biomolecular delivery in single-cell patterns. Pulsed laser scanning-activated photoporation mediated through a micropatterned rGO device facilitates intracellular delivery in cell micropatterns.
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Automation-assisted human skin-on-a-chip for modeling ultraviolet-induced injury and evaluating photoprotective and regenerative modalities

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00134C, Paper

Yu-Jeong Lee, Jieun Lee, Yoojin Na, Hoon Suk Rho, Min-Kyu Kang, YongTae Kim, Jeong-Kee Yoon
An automation-assisted human skin-on-a-chip platform integrating epidermal and dermal monolayers was developed to model UVB-induced skin injury and to evaluate photoprotective (ZnO and BP-3) and regenerative (iMSC-derived nanovesicle) modalities.
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A novel 3D-printed tool for in vitro cell interaction studies under flow conditions

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00033A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Katharina Skoll, Maria Zobl, Elke Heiss, Barbara Braunboeck, Samuel Meerkatz, Franz Radner, Samuel Castonguay, Markus Holzner, Adriana Zbiral, Michael Wirth, Maria Anzengruber
Experimental setup, sedimentation and shear stress influence cell interaction exposing the limits of static in vitro assays. The FlowCube emerges as a versatile, accessible platform that enables in vitro evaluation in a dynamic flow setting.
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Flow-programmable and reversible surface-induced LLPS in nanofluidic channels

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00003G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ryoichi Ohta, Zhixin Zhao, Xuan Yan, Ruying Wang, Kazuma Mawatari
Nanofluidic confinement enables instantaneous formation and hydrodynamic peel-off of surface LLPS films. In the future, this reversible 3D phase is expected to accommodate functional molecules beyond static 2D limits.
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Lab-on-a-Chip Systems for Microplastic and Nanoplastic Sampling, Detection, Characterization and Bioassessment

Lab Chip, 2026, Accepted Manuscript
DOI: 10.1039/D6LC00116E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Liyuan Gong, Erfan Eskandari, Md Iftakhar Khan, Yang Lin
Microplastics (MPs) and nanoplastics (NPs) are ubiquitous environmental contaminants, with growing evidence of their ecological and human health risks. However, a clear understanding of their impacts remains limited, as challenges...
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An AI-enabled tool for quantifying overlapping red blood cell sickling dynamics in microfluidic assays

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00108D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Nikhil Kadivar, Guansheng Li, Jianlu Zheng, Ming Dao, George Em Karniadakis, Mengjia Xu
AI-assisted masks train nnU-Net to predict cell masks, followed by optional watershed refinement, labeling, counting, and sickling analysis.
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Valved microfluidics with Ostemers

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC00968E, Paper

Naveen Kumar K. R., Saima Hamid, A. K. Niketa, Ekta Prajapati, Shishir Kumar
Ostemer-based valved microfluidics with NOA 84 as a membrane replace PDMS using a three-layer design enables 200 ms switching time with strong chemical resistance, enabling robust and flexible microfluidic systems.
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Capillary microsampling enables on-site collection and storage of plant sap

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00201C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ellinor Hedberg, Jaime Sebastián-Azcona, Federico Ribet, Virginia Hernandez-Santana, Göran Stemme, Antonio Diaz Espejo, Niclas Roxhed
A novel microfluidic plant sap sampling and storage device inspired by the concept of DBS, providing a practical alternative to destructive methods, supporting repeated sampling from the same plant and enabling longitudinal metabolic monitoring.
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Ultra-high throughput droplet microfluidics for cultivation and functional screening of environmental microbial strains and consortia

Lab Chip, 2026, 26,2646-2672
DOI: 10.1039/D5LC01115A, Tutorial Review

Luca Potenza, Jozef Krzak, Maciej S. Andrzejewski, Adam Pyzik, Tomasz S. Kaminski
The scheme illustrates a droplet microfluidic workflow for isolating microorganisms using high-throughput screening (HTS), in which individual cells are encapsulated in droplets, cultivated, sorted, and ultimately recovered as selected strains.
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Human hair regeneration using organoids and hair-on-chip technologies

Lab Chip, 2026, 26,2634-2645
DOI: 10.1039/D6LC00095A, Perspective

Imaan A. Ahmed, Abbas Shafiee
Currently, no therapies exist for regenerating appendage bearing skin. New developments in biofabrication, stem cell research, organoids, and other technologies hold promise for skin regeneration with optimal cosmetic and functional outcomes.
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Microparticle-enabled single cell multiparameter electronic immunophenotyping for selective electroporation

Lab Chip, 2026, 26,2909-2922
DOI: 10.1039/D6LC00180G, Paper

Madeline Hoyle, Josiah Rudge, Yuvraj Rallipalli, Aniruddh Sarkar
Detection of multifrequency impedance signatures of microparticle labeled single cells in a 3D printed microfluidic channel enables real time selective electroporation of cell subpopulations for cell engineering.
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Facile fabrication of high-density two-dimensional micronozzle arrays using twisted thin-wire molds

Lab Chip, 2026, 26,2889-2899
DOI: 10.1039/D6LC00036C, Paper

Koki Takahashi, Kyohei Terao
Rotational skewing of thin-wire arrays enables simple fabrication of dense micronozzle arrays with independently connected channels, allowing localized hydrodynamic flow confinement and microscale liquid processing.
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Bioinspired quality-based sperm sorting in a spiral microfilter-enhanced microfluidic device: enhancing DNA integrity via rheotaxis and boundary dynamics

Lab Chip, 2026, 26,2872-2888
DOI: 10.1039/D5LC00427F, Paper

Donya Shahhoseini, Naser Naserifar
A bioinspired spiral microfluidic device leverages rheotaxis and boundary dynamics for label-free sperm sorting, reducing DNA fragmentation and enhancing viability, providing a practical solution for challenging semen in assisted reproduction.
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Band-stop microfluidics for high-purity, label-free enrichment of viable cancer cells from whole blood

Lab Chip, 2026, 26,2834-2848
DOI: 10.1039/D6LC00039H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lewis Krzeczkowski, Georgios Nteliopoulos, Simak Ali, Paul Davey, R. Charles Coombes, Ali Salehi-Reyhani
A microfluidic band-stop filter selectively enriches viable CTC-sized cells from undiluted whole blood while excluding smaller and larger blood cells. Captured cells remain viable, can be drug-tested on-chip, and recovered off-chip.
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Robotic acoustofluidic single-cell picking and placement platform

Lab Chip, 2026, 26,2820-2833
DOI: 10.1039/D5LC01129A, Paper

Wanqi Li, Qiu Yin, Jiahui Wu, Chenfan Zhang, Xiaochen Li, Chenyang Zhou, Xianting Ding, Xiang Chen
Single-cell manipulation is essential for investigating cellular heterogeneity and enabling downstream assays, such as single-cell proteomics and drug screening.
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Cap-Sweat: a capillary microfluidic platform for digitized sweat sampling and time-resolved biomarker analysis

Lab Chip, 2026, 26,2734-2746
DOI: 10.1039/D5LC01172H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pezhman Jalali, Amir Sanati Nezhad
Wearable capillary device for time-resolved sweat analysis.
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Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva

Lab Chip, 2026, 26,2804-2819
DOI: 10.1039/D5LC01063B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ling Ding, Huizi Zhang, Yao Li, Jun Kameoka
A stitched lyocell–modal microfluidic platform guides saliva to a microneedle-based electrochemical sensor, providing a simple route for low-concentration lactate detection in human saliva.
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A dual-antibody gold nanoparticle-based lateral flow assay for rapid and selective detection of mesenchymal stem cell stemness

Lab Chip, 2026, 26,2789-2803
DOI: 10.1039/D6LC00037A, Paper

Drishya Prakashan, C. A. Amarnath, Shilpa N. Sawant, G. Taru Sharma, Sonu Gandhi
Smartphone readable AuNPs-LFA enables rapid, visual, and qualitative detection of stemness of MSCs.
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An automated modular microfluidic platform for end-to-end mRNA synthesis and purification

Lab Chip, 2026, 26,2923-2936
DOI: 10.1039/D6LC00118A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Vikas Sharma, Amirreza Mottafegh, Jeong-Un Joo, Dong-Pyo Kim
Automated end-to-end microfluidic mRNA production integrates oscillatory IVT with biocatalytic DNase membrane assisted μ-TFF and sensor-guided multimodal chromatography, delivering higher yield, reduced dsRNA and rapid synthesis-to-purification.
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Low-temperature inkjet-printed electrochemical sensors on OSTE+ microfluidics for oxygen monitoring and scavenging

Lab Chip, 2026, 26,2775-2788
DOI: 10.1039/D5LC01117E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Denise Marrero, Ferran Pujol-Vila, Eva Tuset, Gemma Gabriel, Rosa Villa, Mar Alvarez, Xavi Illa
Photonic curing sinters gold and silver nanoparticle inks without damaging polymer substrates. Real-time oxygen scavenging is monitored using electrochemical sensors. Tunable oxygen gradients are achieved in OSTE+ microfluidics for OoC models.
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Integration of continuous microfluidic electrokinetic bioparticle preconcentration with programmable extraction into a discrete microfluidic platform

Lab Chip, 2026, 26,2709-2719
DOI: 10.1039/D5LC00647C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Amir Hillman, Sinwook Park, Gilad Yossifon
Ion concentration polarization-based electrokinetic molecular preconcentration in a flowing microchannel, followed by electrowetting-on-dielectric extraction into discrete droplets within an integrated continuous-digital microfluidic platform.
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A 3D-printed electromagnetically actuated microgripper system for precision single-cell manipulation

Lab Chip, 2026, 26,2900-2908
DOI: 10.1039/D6LC00081A, Paper

Xi Chen, Qingying Ren, Wenshuo Zhao, Minhao Wang, Yining Guo, Jing Huang, Xuhui Zhao, Xinyu Lu, Yuan Liu, Haifeng Xu
A 3D-printed electromagnetic microgripper enabling controllable single-cell manipulation with stable actuation and a liquid-retention structure.
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Rapid desiccation and on-disc rehydration of extracellular vesicles for non-cryogenic preservation

Lab Chip, 2026, 26,2761-2774
DOI: 10.1039/D6LC00014B, Paper

Hyun-Kyung Woo, Sangjin Seo, Advitiya Mahajan, Seoyoung Lee, Seoyoon Bae, Jeremy M. Quintana, Changhyun Kim, Alptekin Aksan, Hakho Lee
AridEx is a centrifugal microfluidic platform for ambient-temperature storage of extracellular vesicles (EVs). This system preserves EV integrity and protein expression, providing a sustainable alternative to −80 °C storage.
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Multi-wavelength transparent microfluidic device for UV-visible illumination and X-ray scattering studies of photoactive systems

Lab Chip, 2026, 26,2697-2708
DOI: 10.1039/D5LC01116G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Benedetta Marmiroli, Sumea Klokic, Barbara Sartori, Marie Reißenbüchel, Alessio Turchet, Heinz Amenitsch
A microchannel transparent to X-rays in one direction and to UV and visible light in the perpendicular direction allows optimizing illumination for studying structural transitions of liquid samples under photoexcitation.
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High-speed liquid switching and on-chip force sensing reveal the transient mechanical response of MscL in Synechocystis sp. PCC 6803

Lab Chip, 2026, 26,2861-2871
DOI: 10.1039/D6LC00004E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xu Du, Masaru Tsujii, Nobuyuki Uozumi, Fumihito Arai
High-speed liquid switching with on-chip force sensing enables millisecond extracellular regulation and quantification of the transient mechanical response of a single cell during osmotic stimulation.
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An automated and portable platform for rapid cell-free DNA isolation and its application in microbial DNA metagenomic sequencing from human blood samples

Lab Chip, 2026, 26,2849-2860
DOI: 10.1039/D5LC00876J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Linda Marriott, Ana Martinez-Lopez, Antonio Liga, Kazuhiro Horiba, Amanda Warr, Jacob N. Phulusa, Radhe Shantha Kumar, Laura Carey, Yoshinori Ito, Benjamin J. Parcell, Nicholas R. Leslie, Nicholas A. Feasey, Shevin T. Jacob, Jamie Rylance, Maïwenn Kersaudy-Kerhoas
CNASafe, a portable automated platform, rapidly isolates plasma cfDNA with yields comparable to standard kits, enabling real-time nanopore sequencing and detection of pathogens missed by blood culture within hours.
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Stroke volume analog on a chip – in vitro hydrodynamic model of cardiac pumping efficiency

Lab Chip, 2026, 26,2720-2733
DOI: 10.1039/D5LC00547G, Paper

John F. Zimmerman, Luke A. MacQueen, Douglas Henze, Daniel J. Drennan, Sean L. Kim, Herdeline Ann M. Ardoña, Suji Choi, Qianru Jin, Kevin Kit Parker
We demonstrate the use of muscular thin films (MTFs) as a hydrodynamic assay to measure cardiac stroke volume on a chip, and quantify changes in response to ionotropic dosing; helping bridge the gap between in vitro and in vivo measurements.
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Vector-free DNA transfection by nuclear envelope mechanoporation

Lab Chip, 2026, 26,2673-2683
DOI: 10.1039/D5LC00871A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Leyla Akh, Apresio K. Fajrial, Sunwoo Sohn, Benjamin Seelbinder, Xin Xu, Wei Tan, Jill E. Slansky, Corey P. Neu, Xiaoyun Ding
A nanolancet-based microfluidic mechanoporation device can produces reliable pores on the cell membrane and nuclear envelope. The platform allows intracellular and nuclear delivery of cargo such as plasmid DNA in high throughput.
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A 3D model to evaluate cell chemotaxis within a heterogenic tumor microenvironment

Lab Chip, 2026, 26,2747-2760
DOI: 10.1039/D5LC00763A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Daniel B. Rodrigues, Daniela Cruz-Moreira, Luca Gasperini, Mariana Jarnalo, Ricardo Horta, Rui L. Reis, Rogério P. Pirraco
Custom tailored 3D chemotaxis chambers allow better comprehension of intercellular crosstalk between tumor and stromal cells corroborating the role of tumor cells in the recruitment of supporting cells into the tumor microenvironment.
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Smarter cell sorting: droplet microfluidics meets pick-and-place sorting

Lab Chip, 2026, 26,2684-2696
DOI: 10.1039/D5LC00550G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Olivia Gerhard, Steffen Schneider, Michaela Dehne, Janina Bahnemann, Klaus Palme, Ralf Welsch, Oleksandr Dovzhenko, Qiuju Yu, Michael Köhler, Jialan Cao, Alexander Groß
A microfluidic transfer tool (MTT) was designed to pick objects and store them intermediately in a droplet sequence before placement. Overall system achieved a significantly increased throughput when sorting 50 μm polymer beads or 20 μm plant pollen.
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A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh

Lab Chip, 2026, Advance Article
DOI: 10.1039/D6LC00182C, Paper

Shogo Iwai, Daisuke Sasaki, Tetsutaro Kikuchi, Katsuhisa Matsuura, Kenjiro Fukuda, Sunghoon Lee, Tatsuya Shimizu, Takao Someya, Shinjiro Umezu
An ultrathin, stretchable nanomesh-based system enables contractile force measurement of cardiac tissue under mechanical stretch. It demonstrates stretch-dependent increases in contractile force and drug responses.
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Size-based sorting of cancer cells reveals functional heterogeneity among subpopulations

Lab Chip, 2026, Advance Article
DOI: 10.1039/D5LC01042J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Esra Yilmaz, Zhimeng Fan, Jason P. Beech, Vinay S. Swaminathan, Jonas O. Tegenfeldt
Cancer cells of type MDA-MB-231 were sorted based on size using deterministic lateral displacement. The results reveal differences with respect to size in morphology, adhesion dynamics, and invasion potential.
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