RSC - Lab Chip latest articles

Optofluidics 2013

Lab Chip, 2013, 13,2673-2674
DOI: 10.1039/C3LC90054A, Editorial

Ai-Qun Liu, Changhuei Yang
Professors Ai-Qun Liu and Changhuei Yang present a themed issue on Optofluidics.
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Research highlights

Lab Chip, 2013, 13,2727-2730
DOI: 10.1039/C3LC90055J, Highlight

Imee G. Arcibal, Mehmet R. Dokmeci, Ali Khademhosseini
DNA structure and sequence mapping in a nanofluidic device - Microfluidic tissue processor for biomarker detection - Microfluidic full field imaging of multiple chemical species concentrations.
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Optofluidic-tunable color filters and spectroscopy based on liquid-crystal microflows

Lab Chip, 2013, 13,2721-2726
DOI: 10.1039/C3LC50501D, Paper

J. G. Cuennet, A. E. Vasdekis, D. Psaltis
Optofluidic color filters based on liquid crystal micro-flow are presented. The filters are tuneable by modifying both the inlet pressure and channel geometry, and enabled on-chip absorption spectroscopy.
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Biosensing MAPs as "roadblocks": kinesin-based functional analysis of tau protein isoforms and mutants using suspended microtubules (sMTs)

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50151E, Paper

Mehmet C. Tarhan, Yslam Orazov, Ryuji Yokokawa, Stanislav L. Karsten, Hiroyuki Fujita
We have used a suspended MT-kinesin assay to compare the effect of different tau isoforms and mutations on the kinesin velocity.
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On-demand droplet loading for automated organic chemistry on digital microfluidics

Lab Chip, 2013, 13,2785-2795
DOI: 10.1039/C3LC41363B, Paper

Gaurav J. Shah, Huijiang Ding, Saman Sadeghi, Supin Chen, Chang-Jin "CJ" Kim, R. Michael van Dam
We present a versatile and robust technique for on-demand delivery of liquids to a digital microfluidic chip from an off-chip reservoir, using component parts that are inexpensive and potentially disposable.
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Highly enhanced energy conversion from the streaming current by polymer addition

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC41232F, Paper

Trieu Nguyen, Yanbo Xie, Lennart J. de Vreede, Albert van den Berg, Jan C. T. Eijkel
We show an experimental demonstration of the effect of high concentrations of polymer added to the working solution in a microchannel and how it greatly enhances the energy conversion efficiency from the pressure induced streaming current.
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Robust reagent addition and perfusion strategies for droplet-interface bilayers

Lab Chip, 2013, 13,2749-2753
DOI: 10.1039/C3LC41323C, Technical Innovation

Max Lein, Jing Huang, Matthew A. Holden
DIB utility expanded using new fluidic devices that enable addition or perfusion of reagents.
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Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics

Lab Chip, 2013, 13,2840-2847
DOI: 10.1039/C3LC50178G, Paper

Barry Lutz, Tinny Liang, Elain Fu, Sujatha Ramachandran, Peter Kauffman, Paul Yager
Sugar solutions dried on paper create dissolvable flow delays that can be tuned from minutes to nearly an hour. We present a folding card format that uses paper networks and dissolvable delays to automate a multi-step signal-amplified immunoassay.
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Simultaneous measurement of liquid absorbance and refractive index using a compact optofluidic probe

Lab Chip, 2013, 13,2682-2685
DOI: 10.1039/C3LC50157D, Communication

Maurine Malak, Frederic Marty, Tarik Bourouina, Dan Angelescu
An all-silicon Michelson interferometer is used as an optofluidic infrared probe for simultaneous measurement of the absorbance and refractive index of thin films.
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On-chip microlasers for biomolecular detection via highly localized deposition of a multifunctional phospholipid ink

Lab Chip, 2013, 13,2701-2707
DOI: 10.1039/C3LC50149C, Paper

Uwe Bog, Thomas Laue, Tobias Grossmann, Torsten Beck, Tobias Wienhold, Benjamin Richter, Michael Hirtz, Harald Fuchs, Heinz Kalt, Timo Mappes
We demonstrate a novel approach to realize on-chip microlasers, by applying highly localized molecule deposition onto passive photonic whispering gallery mode microresonators. In a proof-of-principle we apply these low-threshold lasers as biosensors.
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Simple replica micromolding of biocompatible styrenic elastomers

Lab Chip, 2013, 13,2773-2784
DOI: 10.1039/C3LC50426C, Paper

Mark D. Borysiak, Kevin S. Bielawski, Nathan J. Sniadecki, Colin F. Jenkel, Bryan D. Vogt, Jonathan D. Posner
Microdevices fabricated from styrene-ethylene/butylene-styrene (SEBS) copolymers offer many of the appealing properties of polystyrene with simple elastomeric fabrication similar to PDMS.
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Sequential multi-molecule delivery using vortex-assisted electroporation

Lab Chip, 2013, 13,2764-2772
DOI: 10.1039/C3LC50196E, Paper

Hoyoung Yun, Soojung Claire Hur
A vortex-assisted microfluidic electroporator for sequential multi-molecule delivery to pre-selected target cells with precise and independent molecular amount and parameter controllability.
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Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae

Lab Chip, 2013, 13,2754-2763
DOI: 10.1039/C3LC50162K, Paper

Michael D. Vahey, Laia Quiros Pesudo, J. Peter Svensson, Leona D. Samson, Joel Voldman
Using a microfluidic platform to sort cells according to differences in their electrical properties, we screen the yeast deletion strains to map cellular genotype to electrical phenotype.
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CD4 counting technologies for HIV therapy monitoring in resource-poor settings - state-of-the-art and emerging microtechnologies

Lab Chip, 2013, 13,2731-2748
DOI: 10.1039/C3LC50213A, Critical Review

Macdara T. Glynn, David J. Kinahan, Jens Ducree
This review surveys current and emerging microfluidic and alternative point-of-care technologies for HIV diagnostics in resource-poor regions.
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Magnetically actuated artificial cilia for optimum mixing performance in microfluidics

Lab Chip, 2013, 13,2834-2839
DOI: 10.1039/C3LC50407G, Paper

Chia-Yuan Chen, Chia-Yun Chen, Cheng-Yi Lin, Ya-Ting Hu
We report an active micromixer using magnetically actuated artificial cilia to reach the optimum mixing performance for highly viscous flows.
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A nanofluidic device for single molecule studies with in situ control of environmental solution conditions

Lab Chip, 2013, 13,2821-2826
DOI: 10.1039/C3LC50233C, Paper

Ce Zhang, Kai Jiang, Fan Liu, Patrick S. Doyle, Jeroen A. van Kan, Johan R. C. van der Maarel
Design, fabrication and application study of a nanofluidic device for the dynamic response of untethered, single biomacromolecules to a change in environmental solution conditions.
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A microfluidic concentration-gradient droplet array generator for the production of multi-color nanoparticles

Lab Chip, 2013, 13,2815-2820
DOI: 10.1039/C3LC50254F, Paper

Chun-Guang Yang, Zhang-Run Xu, Abraham P. Lee, Jian-Hua Wang
We present a microfluidic droplet generator which could simultaneously form concentration-gradient droplets in 64 parallel channels for producing multi-color nanoparticles.
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Protein-protein interaction analysis in single microfluidic droplets using FRET and fluorescence lifetime detection

Lab Chip, 2013, 13,2808-2814
DOI: 10.1039/C3LC00057E, Paper

Christian Benz, Heiko Retzbach, Stefan Nagl, Detlev Belder
Protein-protein interactions were monitored using fluorescence lifetime measurements with FRET within microdroplets and a model competitive droplet protein assay was developed capable of detecting unlabelled avidin in the nanomolar range within 135 s.
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In silico evolution of guiding track designs for molecular shuttles powered by kinesin motors

Lab Chip, 2013, 13,2827-2833
DOI: 10.1039/C3LC41103F, Paper

Takuya Sunagawa, Akihito Tanahashi, Matthew E. Downs, Henry Hess, Takahiro Nitta
A design method inspired by biological evolution enabled automated designs of mechanical nanodevices powered by kinesin motors.
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A micro-rheological method for determination of blood type

Lab Chip, 2013, 13,2796-2801
DOI: 10.1039/C3LC40790J, Paper

Sylwia Makulska, Slawomir Jakiela, Piotr Garstecki
The measurement of time and distance can be used for determination of agglutination in small (nL) samples of liquid.
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Chemiluminescence detector based on a single planar transparent digital microfluidic device

Lab Chip, 2013, 13,2714-2720
DOI: 10.1039/C3LC50170A, Paper

Xiangyu Zeng, Kaidi Zhang, Jian Pan, Guoping Chen, Ai-Qun Liu, Shih-Kang Fan, Jia Zhou
A compact and portable chemiluminescence detector prototype based on a single planar single polar transparent EWOD device is proposed.
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Electrically tunable optofluidic light switch for reconfigurable solar lighting

Lab Chip, 2013, 13,2708-2713
DOI: 10.1039/C3LC50204J, Paper

Wuzhou Song, Demetri Psaltis
We experimentally demonstrated an electrically tunable optofluidic light switch which takes the key role for a reconfigurable solar lighting system.
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Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions

Lab Chip, 2013, 13,2802-2807
DOI: 10.1039/C3LC50257K, Paper

Giovanni Romeo, Gaetano D'Avino, Francesco Greco, Paolo A. Netti, Pier Luca Maffettone
Particles suspended in non-Newtonian liquids flowing in channels may migrate transversally to the main flow direction as a result of normal stress gradients.
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Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system

Lab Chip, 2013, 13,2693-2700
DOI: 10.1039/C3LC50105A, Paper

J. Q. Yu, X. F. Liu, L. K. Chin, A. Q. Liu, K. Q. Luo
To better understand how hyperglycemia induces endothelial cell dysfunction under the diabetic conditions, a hemodynamic microfluidic chip system was developed.
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Single-mode biological distributed feedback laser

Lab Chip, 2013, 13,2675-2678
DOI: 10.1039/C3LC50140J, Communication

Christoph Vannahme, Florian Maier-Flaig, Uli Lemmer, Anders Kristensen
Single-mode second order distributed feedback lasers of vitamin doped gelatine films on nanostructured low refractive index material are demonstrated.
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Highly sensitive fluorescent protein FRET detection using optofluidic lasers

Lab Chip, 2013, 13,2679-2681
DOI: 10.1039/C3LC50207D, Communication

Qiushu Chen, Xingwang Zhang, Yuze Sun, Michael Ritt, Sivaraj Sivaramakrishnan, Xudong Fan
Optofluidic protein laser provides a better way to study protein interactions.
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Molecular-level dengue fever diagnostic devices made out of paper

Lab Chip, 2013, 13,2686-2692
DOI: 10.1039/C3LC50135C, Paper

Shih-Jie Lo, Shih-Chun Yang, Da-Jeng Yao, Jiann-Hwa Chen, Wu-Chun Tu, Chao-Min Cheng
Paper-based diagnostic devices for the diagnosis of serotype-2 dengue virus infection via a combination of isothermal nucleic acid amplification and fluorescence reporters.
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Microfluidic heart on a chip for higher throughput pharmacological studies

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50350J, Paper

Ashutosh Agarwal, Josue Adrian Goss, Alexander Cho, Megan L. McCain, Kevin Kit Parker
We present the design of a higher throughput "heart on a chip" which utilizes a semi-automated fabrication technique to process sub millimeter sized thin film cantilevers of soft elastomers. Anisotropic...
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Push pull microfluidics on a multi-level 3D CD

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC00004D, Paper

Tzer Hwai Gilbert Thio, Fatimah Ibrahim, Wisam Al-Faqheri, Jacob Moebius, Noor Sakinah Khalid, Norhayati Soin, Maria Kahar Bador Abdul Kahar, Marc Madou
We present a novel push and pull bi-directional pumping mechanism on a centrifugal microfluidic CD platform. The thermally actuated pumping mechanism allows for implementation of advanced applications such as valveless switch pumping.
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Advances of lab-on-a-chip in isolation, detection and post-processing of circulating tumour cells

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC00052D, Tutorial Review

Ling Yu, Shu Rui Ng, Yang Xu, Hua Dong, Ying Jun Wang, Chang Ming Li
This review surveys and discusses the progresses of nanotechnologies-based techniques to achieve isolation and characterization of viable circulating tumor cells.
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Scaling and systems biology for integrating multiple organs-on-a-chip

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50243K, Critical Review

John Wikswo, Erica Curtis, Zachary Eagleton, Brian Evans, Ayeeshik Kole, Lucas Hofmeister, William Matloff
This is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication. Accepted manuscripts are published online shortly after acceptance. This version of the article will be replaced by the fully edited, formatted and proof read Advance Article as soon as this is available.
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Simple modular systems for generation of droplets on demand

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50340B, Paper

Krzysztof Churski, Michal Nowacki, Piotr M Korczyk, Piotr Garstecki
This report provides practical guidelines for the use of inexpensive electromagnetic valves characterized by large (tens to hundreds of uL) dead volumes for generation of small (nL) droplets on demand...
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Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50493J, Paper

Brendon Baker, Britta Trappmann, Sarah C Stapleton, Esteban Toro, Christopher S. Chen
Gradients of diffusive molecules within 3D extracellular matrix (ECM) are essential in guiding many processes such as development, angiogenesis, and cancer. The spatial distribution of factors that guide these processes...
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A Microfluidic Approach for Protein Structure Determination at Room Temperature via on-chip Anomalous Diffraction

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50276G, Communication

Sarah Louise Perry, Sudipto Guha, Ashtamurthy Pawate, Amrit Bhaskarla, Vinayak Agarwal, Satish Nair, Paul Kenis
We report a microfluidic approach for de novo protein structure determination via crystallization screening and optimization, as well as on-chip X-ray diffraction data collection. The structure of phosphonoacetate hydrolase (PhnA)...
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Bubble-free electrode actuation for micro-preparative scale electrophoresis of RNA

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50332A, Paper

Paul Vulto, Phillip Kuhn, Gerald A. Urban
This article demonstrates the use of silver/silver chloride electrodes in a salt-bridge system for bubble-free actuation in chip-based electrophoresis systems.
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Alginate gel microwell arrays using electrodeposition for three-dimensional cell culture

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50455G, Paper

Fumisato Ozawa, Kosuke Ino, Toshiharu Arai, Javier Ramon-Azcon, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue
In this study, we developed a novel method for fabricating microwell arrays constructed from alginate gels. The alginate gel microwells were used for three-dimensional (3D) cell culture.
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Low-Cost Fabrication of Centimetre-Scale Periodic Arrays of Single Plasmid DNA Molecules

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50562F, Paper

Brett Kirkland, Zhibin Wang, Peipei Zhang, Shin-ichiro Takebayashi, Steven Lenhert, David M. Gilbert, Jingjiao Guan
We report development of a low-cost method to generate a centimetre-scale periodic array of single plasmid DNA of 11 kilobase pairs. The arrayed DNA is amenable to enzymatic and physical...
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Out of cleanroom, self-assembled magnetic artificial cilia

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50458A, Paper

Ye Wang, Yang Gao, Hans M. Wyss, Patrick Anderson, Jaap den Toonder
Micro-sized hair-like structures, such as cilia, are abundant in nature and have various functionalities. Many efforts have been made to mimic the fluid pumping function of cilia, but most of...
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A simple three-dimensional-focusing, continuous-flow mixer for the study of fast protein dynamics

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50497B, Paper

Kelly S. Burke, Dzmitry Parul, Michael J. Reddish, R. Brian Dyer
We present a simple, yet flexible microfluidic mixer with a demonstrated mixing time as short as 80 [small mu ]s that is widely accessible because it is made of commercially available parts.
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Dielectrophoresis based continuous-flow nano sorter: fast quality control of gene vaccines

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50475A, Paper

Martina Viefhues, Sonja Wegener, Anja Rischmuller, Martin Schleef, Dario Anselmetti
Dielectrophoresis at two nanoslits is exploited for the in-production continuous-flow quality control of gene vaccines.
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Thermal loading in flow-through electroporation microfluidic devices

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50382H, Paper

Blanca del Rosal, Chen Sun, Despina Nelie Loufakis, Chang Lu, Daniel Jaque
Fluorescence thermal imaging has been used to evaluate thermal loading effects in flow-through electroporation microfluidic devices.
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Design and fabrication of uniquely shaped thiol-ene microfibers using a two-stage hydrodynamic focusing design

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50413A, Paper

Darryl A. Boyd, Adam R. Shields, Peter B. Howell, Frances S. Ligler
A two-stage hydrodynamic focusing channel shapes and sizes complex polymer fibers.
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Pencil-on-paper: electronic devices

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50406A, Focus

Narendra Kurra, Giridhar U. Kulkarni
A pencil-trace on paper is a simple way of defining conducting tracks which have potential in making inexpensive paper based electronic devices.
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Superimposed topographic and chemical cues synergistically guide neurite outgrowth

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50174D, Paper

Arnab Kundu, Liesbeth Micholt, Sarah Friedrich, Danielle R. Rand, Carmen Bartic, Dries Braeken, Andre Levchenko
Using a novel microfabricated analysis platform, we investigate the response of primary mouse embryonic hippocampal neurons to superimposed topographic and soluble chemical cues.
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A frequency reconfigurable antenna based on digital microfluidics

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50275A, Technical Innovation

Yasin Damgaci, Bedri A. Cetiner
We present a novel antenna reconfiguration mechanism relying on electrowetting based digital microfluidics to implement a frequency reconfigurable antenna.
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Single cell detection using a magnetic zigzag nanowire biosensor

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50457C, Paper

Hao-Ting Huang, Tzong-Rong Ger, Ya-Hui Lin, Zung-Hang Wei
A magnetic zigzag nanowire device was designed for single cell biosensing.
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A microdevice for studying intercellular electromechanical transduction in adult cardiac myocytes

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50414J, Paper

Xu Zhang, Qian Wang, Brian Gablaski, Xiaojin Zhang, Pamela Lucchesi, Yi Zhao
Intercellular electromechanical transduction in adult cardiac myocytes plays an important role in regulating heart function.
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A low sample volume particle separation device with electrokinetic pumping based on circular travelling-wave electroosmosis

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50343G, Paper

Shiang-Chi Lin, Jau-Ching Lu, Yu-Lung Sung, Chih-Ting Lin, Yi-Chung Tung
Using circular travelling electroosmosis, a particle-separation microfluidic device with low-volume and low-voltage can be implemented.
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Fabrication of integrated porous glass for microfluidic applications

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC41311J, Paper

Sertan Sukas, Roald M. Tiggelaar, Gert Desmet, Han J. G. E. Gardeniers
This paper presents a method for the fabrication of integrated porous silica layers in microfluidic channel networks by microfabrication techniques.
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Nanoimprint lithography with a focused laser beam for the fabrication of nanopatterned microchannel molds

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50202C, Communication

Hyungjun Lim, Jihyeong Ryu, Geehong Kim, Kee-Bong Choi, Sunghwi Lee, Jaejong Lee
We present a process based on nanoimprint lithography for the fabrication of a microchannel mold having nanopatterns formed at the bottoms of its microchannels. A focused laser beam selectively cures...
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Smartphone based health accessory for colorimetric detection of biomarkers in sweat and saliva

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50431J, Paper

Vlad Oncescu, Dakota O'Dell, David Erickson
The mobile health market is rapidly expanding and portable diagnostics tools offer an opportunity to decrease costs and increase the availability of healthcare. Here we present a smartphone based accessory...
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Influence of real-world environments on the motion of catalytic bubble-propelled micromotors

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50446H, Paper

Guanjia Zhao, Hong Wang, Bahareh Khezri, Richard D. Webster, Martin Pumera
The motion of the Pt-catalyzed bubble-propelled microjets in tap, rain, lake and seawater was found to be suppressed.
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A novel microfluidic co-culture system for investigation of bacterial cancer targeting

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50163A, Paper

Jung Woo Hong, Sukhyun Song, Jennifer H. Shin
A microfluidic device to study the chemotactic preference of bacteria for multiple cell types (e.g. cancer vs. normal) in a single integrated platform.
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A lipobead microarray assembled by particle entrapment in a microfluidic obstacle course and used for the display of cell membrane receptors

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50083G, Paper

Xiaoxiao Chen, Shahab Shojaei-Zadeh, M. Lane Gilchrist, Charles Maldarelli
A microfluidic array for the display of cell membrane receptors is constructed by sequestering the biomolecules in supported lipid bilayers formed around microbeads, which are arrayed by capture in an obstacle course of traps.
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Passive breakups of isolated drops and one-dimensional assemblies of drops in microfluidic geometries: experiments and models

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC00040K, Paper

Louis Salkin, Alexandre Schmit, Laurent Courbin, Pascal Panizza
Combining experiments and theory, we investigate the breakup dynamics of drops and bubbles with two microfluidic geometries, rectangular obstacles and asymmetric loops.
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Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC41343H, Communication

Zongxing Wang, Hung-jen Wu, Daniel Fine, Jeffrey Schmulen, Ye Hu, Biana Godin, John X. J. Zhang, Xuewu Liu
Microfluidic devices consisting of micropillars with porous-silicon-nanowire cilia, for the isolation and recovery of intact exosome-like vesicles while filtering out proteins and cell debris.
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Integrating biological vasculature into a multi-organ-chip microsystem

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50217A, Paper

Katharina Schimek, Mathias Busek, Sven Brincker, Benjamin Groth, Silke Hoffmann, Roland Lauster, Gerd Lindner, Alexandra Lorenz, Ulrike Menzel, Frank Sonntag, Heike Walles, Uwe Marx, Reyk Horland
A chip-based platform mimicking the transport function of the cardiovascular system, a crucial part of future human-on-a-chip culture, was developed.
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Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50402F, Paper

Chen-Ta Ho, Ruei-Zeng Lin, Rong-Jhe Chen, Chung-Kuang Chin, Song-En Gong, Hwan-You Chang, Hwei-Ling Peng, Long Hsu, Tri-Rung Yew, Shau-Feng Chang, Cheng-Hsien Liu
A liver-lobule-mimetic reconstruction for centimeter-scale liver tissue of heterogeneous hepatic and endothelial cells is demonstrated. This could be promisingly applied to the fields of tissue engineering, drug development and liver physiology studies.
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Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50249J, Paper

Mingjian Shi, Devi Majumdar, Yandong Gao, Bryson M. Brewer, Cody R. Goodwin, John A. McLean, Deyu Li, Donna J. Webb
Microfluidic platforms for imaging synaptic contact (arrow) between live neurons, differentially transfected with synaptic markers (mCerulean-actin, cyan; mCherry-synaptophysin, red), that are co-cultured with glia.
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Surface acoustic waves for on-demand production of picoliter droplets and particle encapsulation

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50372K, Paper

David Collins, Tuncay Alan, Kristian Helmerson, Adrian Neild
Microscopic water-in-oil droplets are a versatile chemical and biological platform whose dimensions result in short reaction times and require minuscule amounts of reagent. Methods exist for the production of droplets,...
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Canadian contributors 2013

Lab Chip, 2013, 13,2433-2437
DOI: 10.1039/C3LC90053C, Profile

Contributors to the Canada issue.
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Lab on a chip Canada - rapid diffusion over large length scales

Lab Chip, 2013, 13,2438-2440
DOI: 10.1039/C3LC90052E, Editorial

David Juncker, Aaron R. Wheeler, David Sinton
Guest Editors David Juncker, David Sinton and Aaron Wheeler highlight the contribution of Canadian research to microfluidics.
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Recent developments in microfluidics-based chemotaxis studies

Lab Chip, 2013, 13,2484-2499
DOI: 10.1039/C3LC50415H, Critical Review

Jiandong Wu, Xun Wu, Francis Lin
We review recent developments in microfluidics-based chemotaxis studies and discuss the new trends in this field.
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A personal stroll through the historical development of Canadian microfluidics

Lab Chip, 2013, 13,2500-2503
DOI: 10.1039/C3LC50522G, Perspective

D. Jed Harrison
The historical background of microfluidics research within Canada is discussed from the personal perspective of the author, D. Jed Harrison.
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Research highlights

Lab Chip, 2013, 13,2441-2444
DOI: 10.1039/C3LC90047A, Highlight

Nasim Annabi, Hojae Bae, Mehmet R. Dokmeci, Ali Khademhosseini
A perfusable vascular network-A gradient generator microfluidic chip-Storing data on a microfluidic chip.
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Multiplexed electrokinetic sample fractionation, preconcentration and elution for proteomics

Lab Chip, 2013, 13,2651-2659
DOI: 10.1039/C3LC50401H, Paper

Yujuan Hua, Abebaw B. Jemere, Jelena Dragoljic, D. Jed Harrison
Both 6 and 8-channel integrated microfluidic sample pretreatment devices capable of performing "in space" sample fractionation, collection, preconcentration and elution of captured analytes via sheath flow assisted electrokinetic pumping are described.
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Microfluidic redox battery

Lab Chip, 2013, 13,2504-2507
DOI: 10.1039/C3LC50499A, Communication

Jin Wook Lee, Marc-Antoni Goulet, Erik Kjeang
We demonstrate a rechargeable membraneless redox battery integrated in a microfluidic chip.
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Lung assist device: development of microfluidic oxygenators for preterm infants with respiratory failure

Lab Chip, 2013, 13,2641-2650
DOI: 10.1039/C3LC41417E, Paper

Wen-I. Wu, Niels Rochow, Emily Chan, Gerhard Fusch, Asmaa Manan, Dipen Nagpal, P. Ravi. Selvaganapathy, Christoph Fusch
This paper reports the development of microfluidic oxygenator (MFO) units designed for a lung assist device (LAD) for newborn infants.
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Recent advances in microfluidic techniques for single-cell biophysical characterization

Lab Chip, 2013, 13,2464-2483
DOI: 10.1039/C3LC50355K, Critical Review

Yi Zheng, John Nguyen, Yuan Wei, Yu Sun
This article reviews recent advances in microfluidic techniques for single-cell biophysical characterization. The advantages and limitations of the techniques are discussed.
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An electrochemical Lab-on-a-CD system for parallel whole blood analysis

Lab Chip, 2013, 13,2634-2640
DOI: 10.1039/C3LC00020F, Paper

Tingjie Li, Yaxi Fan, Yang Cheng, Jun Yang
We have developed a proof-of-concept electrochemical Lab-on-a-CD system for fast and parallel whole blood analysis.
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Bubble gate for in-plane flow control

Lab Chip, 2013, 13,2519-2527
DOI: 10.1039/C3LC50075F, Paper

Ali Oskooei, Milad Abolhasani, Axel Gunther
Miniature gate valve for actively controlling liquid flow in a scalable manner at a footprint of less than one square millimetre.
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Equilibrium gas-oil ratio measurements using a microfluidic technique

Lab Chip, 2013, 13,2623-2633
DOI: 10.1039/C3LC00013C, Paper

Robert Fisher, Mohammad Khalid Shah, Dmitry Eskin, Kurt Schmidt, Anil Singh, Shahnawaz Molla, Farshid Mostowfi
A method for measuring the equilibrium GOR (gas-oil ratio) of reservoir fluids using microfluidic technology is developed.
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High throughput multilayer microfluidic particle separation platform using embedded thermoplastic-based micropumping

Lab Chip, 2013, 13,2615-2622
DOI: 10.1039/C3LC50181G, Paper

Tohid Fatanat Didar, Kebin Li, Maryam Tabrizian, Teodor Veres
We present an integrated thermoplastic elastomer based multilayer microfluidic device with an embedded peristaltic micropump and through-holes membrane for high throughput particle sorting and separation.
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Magnetic timing valves for fluid control in paper-based microfluidics

Lab Chip, 2013, 13,2609-2614
DOI: 10.1039/C3LC00006K, Paper

Xiao Li, Philip Zwanenburg, Xinyu Liu
A new type of magnetically-driven valves capable of counting the time and controlling fluid flows accordingly in paper-based microfluidic devices.
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Quantification of the Young's modulus of the primary plant cell wall using Bending-Lab-On-Chip (BLOC)

Lab Chip, 2013, 13,2599-2608
DOI: 10.1039/C3LC00012E, Paper

Amir Sanati Nezhad, Mahsa Naghavi, Muthukumaran Packirisamy, Rama Bhat, Anja Geitmann
We present a LOC approach to quantitatively determine the Young's modulus of the Camellia pollen tube cell wall based on a whole cell bending test.
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A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions

Lab Chip, 2013, 13,2591-2598
DOI: 10.1039/C3LC00051F, Paper

Michelle B. Chen, Suthan Srigunapalan, Aaron R. Wheeler, Craig A. Simmons
A bilayer membrane microfluidic device incorporating a cell-seeded hydrogel is developed to model the 3D microenvironment of blood vessels and heart valves, enabling study of heterotypic cardiovascular cell communication in physiologically-relevant environments.
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An enclosed in-gel PCR amplification cassette with multi-target, multi-sample detection for platform molecular diagnostics

Lab Chip, 2013, 13,2576-2584
DOI: 10.1039/C3LC41419A, Paper

Dammika P. Manage, Jana Lauzon, Alexey Atrazev, Ravi Chavali, Roshini A. Samuel, Brandon Chan, Y. C. Morrissey, Walter Gordy, Ann L. Edwards, Kyle Larison, Stephanie K. Yanow, Jason P. Acker, George Zahariadis, Linda M. Pilarski
A self-contained cassette tests 16 patients for multi-sample, multi-target PCR, with integrated quality controls.
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On-chip nanohole array based sensing: a review

Lab Chip, 2013, 13,2445-2463
DOI: 10.1039/C3LC50107H, Critical Review

Carlos Escobedo
This critical review examines developments in the on-chip implementation of nanohole array based sensors, examining relevant fabrication methods and operation schemes.
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Atomically flat symmetric elliptical nanohole arrays in a gold film for ultrasensitive refractive index sensing

Lab Chip, 2013, 13,2541-2546
DOI: 10.1039/C3LC41411F, Paper

Gabriela Andrea Cervantes Tellez, Sa'ad Hassan, R. Niall Tait, Pierre Berini, Reuven Gordon
10^-7 refractive index unit bulk index change resolution achieved monitoring transmission intensity changes through elliptical nanohole arrays with symmetric index substrate in an atomically flat gold film.
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Aquifer-on-a-Chip: understanding pore-scale salt precipitation dynamics during CO2 sequestration

Lab Chip, 2013, 13,2508-2518
DOI: 10.1039/C3LC00031A, Paper

Myeongsub Kim, Andrew Sell, David Sinton
We present a lab-on-a-chip approach to study pore-scale salt precipitation dynamics during CO₂ sequestration in saline aquifers-a challenge with this carbon management strategy.
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Cell electroporation by CNT-featured microfluidic chip

Lab Chip, 2013, 13,2585-2590
DOI: 10.1039/C3LC00014A, Paper

Mehdi Shahini, John T. W. Yeow
We present the application of carbon nanotubes for low-voltage cell electroporation performed in a microfluidic device.
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Double nanohole optical trapping: dynamics and protein-antibody co-trapping

Lab Chip, 2013, 13,2563-2568
DOI: 10.1039/C3LC00003F, Paper

Ana Zehtabi-Oskuie, Hao Jiang, Bryce R. Cyr, Douglas W. Rennehan, Ahmed A. Al-Balushi, Reuven Gordon
Optical trapping of a single protein followed by co-trapping of its antibody is demonstrated using a double nanohole.
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Microfluidic origami: a new device format for in-line reaction monitoring by nanoelectrospray ionization mass spectrometry

Lab Chip, 2013, 13,2533-2540
DOI: 10.1039/C3LC41431K, Paper

Andrea E. Kirby, Aaron R. Wheeler
A microfluidic origami device comprising a two-plate-to-one-plate digital microfluidic interface and mass spectrometry emitter.
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Optimized templates for bottom-up growth of high-performance integrated biomolecular detectors

Lab Chip, 2013, 13,2569-2575
DOI: 10.1039/C3LC41416G, Paper

Brian Lam, Richard D. Holmes, Jagotamoy Das, Mahla Poudineh, Andrew Sage, Edward H. Sargent, Shana O. Kelley
Templated electrodeposition of high-performance nanostructured microelectrodes is studied in depth, and an optimal set of materials for cost-effective, reproducible biosensor chips are identified.
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An electrospray ms-coupled microfluidic device for sub-second hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition

Lab Chip, 2013, 13,2528-2532
DOI: 10.1039/C3LC00007A, Paper

Tamanna Rob, Preet Kamal Gill, Dasantila Golemi-Kotra, Derek J. Wilson
In this work, we introduce an integrated, electrospray mass spectrometry-coupled microfluidic chip that supports the complete workflow for 'bottom up' hydrogen/deuterium exchange (HDX) pulse labelling experiments.
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Exploring a direct injection method for microfluidic generation of polymer microgels

Lab Chip, 2013, 13,2547-2553
DOI: 10.1039/C3LC41385C, Paper

Yihe Wang, Ethan Tumarkin, Diego Velasco, Milad Abolhasani, Willie Lau, Eugenia Kumacheva
We explore the application of the "direct injection" method for the preparation of microgels.
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End-faced waveguide mediated optical propulsion of microspheres and single cells in a microfluidic device

Lab Chip, 2013, 13,2554-2562
DOI: 10.1039/C3LC41199K, Paper

Lothar Lilge, Duoaud Shah, Luc Charron
Single cell transport in microfluidic devices is a topic of interest as their utility is becoming appreciated by cell and molecular biologist.
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Cardiac-like flow generator for long-term imaging of endothelial cell responses to circulatory pulsatile flow at microscale

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50123J, Paper

Huaying Chen, James Cornwell, Han Zhang, Tse Lim, Rena Resurreccion, Timothy Port, Gary Rosengarten, Robert E. Nordon
In vitro models of circulatory hemodynamics are required to mimic the microcirculation for study of endothelial cell responses to pulsatile shear stress by live cell imaging.
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Regeneration-on-a-Chip? The perspectives on use of microfluidics in regenerative medicine

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50293G, Critical Review

Bjorn Harink, Severine Le Gac, Roman Truckenmuller, Clemens A. van Blitterswijk, Pamela Habibovic
The aim of regenerative medicine is to restore or establish normal function of damaged tissues or organs. Tremendous efforts are placed into development of novel regenerative strategies, involving (stem) cells,...
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An integrated microfluidic platform for evaluating in-vivo antimicrobial activity of natural compounds using a whole-animal infection model

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50264C, Paper

Jianping Yang, Zuanguang Chen
The nematode Caenorhabditis elegans is a useful model host for pathogenesis research that can be infected by a large number of human pathogens. Conventionally, nematode-pathogen infection assays are mainly performed...
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Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50240F, Critical Review

Eva-Maria Materne, Alexander G. Tonevitsky, Uwe Marx
In this review, we focus on advanced microfluidic microscale liver equivalents, appraising them against the level of architectural and, consequently, functional identity with their human counterpart in vivo.
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Hydrogel-coated microfluidic channels for cardiomyocyte culture

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50252J, Paper

Nasim Annabi, Seila Selimovic, Juan Pablo Acevedo Cox, Joao Ribas, Mohsen Afshar Bakooshli, Deborah Heintze, Anthony S. Weiss, Donald Cropek, Ali Khademhosseini
A method to coat microfluidic channels with a hydrogel to promote cell adhesion for organ-on-a-chip applications is presented.
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Electrochemical velocimetry on centrifugal microfluidic platforms

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50472G, Paper

Kameel Abi-Samra, Tae-Hyeong Kim, Dong-Kyu Park, Nahui Kim, Jintae Kim, Hanshin Kim, Yoon-Kyoung Cho, Marc J Madou
Expanding upon recent applications of interfacing electricity with centrifugal microfluidic platforms, we introduce electrochemical velocimetry to monitor flow in real-time on rotating fluidic devices. Monitoring flow by electrochemical techniques requires...
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A microbead incorporated centrifugal sample pretreatment microdevice

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50266J, Paper

Tae Seok Seo, Jae Hwan Jung, Byung Hyun Park, Young Ki Choi
In this study, we present a novel bead incorporated centrifugal sample pretreatment microdevice to purify influenza A H3N2 viral RNA. Simple revolution per minute (RPM) control can lead to the...
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A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50424G, Paper

Yu-Hsiang Hsu, Monica L. Moya, Christopher C. W. Hughes, Steven C. George, Abraham P. Lee
A resistive circuit-based microfluidic platform for the generation of large-scale microtissue arrays.
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Rapid fabrication of pressure-driven open-channel microfluidic devices in omniphobic RF paper

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50371B, Paper

Ana C. Glavan, Ramses V. Martinez, E. Jane Maxwell, Anand Bala Subramaniam, Rui M. D. Nunes, Siowling Soh, George M. Whitesides
We describe the fabrication of pressure-driven, open-channel microfluidic systems in omniphobic paper, and the development of new types of valves and switches.
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Immobilization of the nematode caenorhabditis elegans with addressable light-induced heat knockdown (ALINK)

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50454A, Paper

Han-Sheng Chuang, Hsiang-Yu Chen, Chang-Shi Chen, Wen-Tai Chiu
Caenorhabditis (C.) elegans is a model animal used in genetics, neuroscience, and developmental biology.
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Multiplexed single molecule immunoassays

Lab Chip, 2013, Advance Article
DOI: 10.1039/C3LC50416F, Paper

David M. Rissin, Cheuk W. Kan, Linan Song, Andrew J. Rivnak, Matthew W. Fishburn, Qichao Shao, Tomasz Piech, Evan P. Ferrell, Raymond E. Meyer, Todd G. Campbell, David R. Fournier, David C. Duffy
We report the first single molecule immunoassay capable of measuring multiple proteins at subfemtomolar concentrations for use in multivariate diagnostics.
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Label-free optical detection of cells grown in 3D silicon microstructures

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50317H, Paper

Sabina Merlo, Francesca Carpignano, Gloria Silva, Francesca Aredia, Anna Ivana Scovassi, Giuliano Mazzini, Salvatore Surdo, Giuseppe Barillaro
We demonstrate high aspect-ratio photonic crystals that could serve as three-dimensional (3D) microincubators for cell culture and also provide label-free optical detection of the cells. The investigated microstructures, fabricated by...
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Assessment of pathogen bacteria using periodic actuation

Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC50411E, Paper

Sorin David, Cristina Polonschii, Mihaela Gheorghiu, Alin Dobre, Dumitru Bratu, Eugen Gheorghiu
A new analytic platform for assessment of pathogenic bacteria is presented. It is based on a robust technology able to amplify the signal to noise ratio providing fast and sensitive...
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