RSC - RSC Mechanochem. latest articles

Moving mechanochemistry forward: mechanochemistry and organometallic synthesis

RSC Mechanochem., 2026, 3,327-329
DOI: 10.1039/D6MR90009G, Editorial

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Dillon Button-Jennings, Timothy P. Hanusa
Dillon Button-Jennings and Timothy Hanusa examine the contributions of mechanochemical methods to the field of organometallic synthesis.
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Ball-milling synthesis of α-bromoacrylates from solvent-free in situ prepared ethyl diethylbromophosphonate

RSC Mechanochem., 2026, 3,459-465
DOI: 10.1039/D6MR00029K, Paper

Open Access

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Marie Caldiero, Jean-Philippe Bouillon, Thomas Castanheiro
A mechanosynthesis of α-bromoacrylates was described from commercially available triethyl phosphonoacetate through a ball-milling-assisted bromination/HWE one-pot process. α-iodo- and α-chloroacrylates were also accessible using NIS and NCS.
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Mechanosynthesis of cocrystals and coamorphous binary drug–drug systems with apremilast core: structural and biological studies

RSC Mechanochem., 2026, 3,444-458
DOI: 10.1039/D6MR00014B, Paper

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K. Trzeciak, R. Dolot, M. K. Dudek, E. Wielgus, S. Kazmierski, P. Paluch, J. Czernek, J. Brus, K. Wiktorska, I. Wadas, K. Głowacka, A. Lange, M. J. Potrzebowski
New solid-state forms of apremilast, an effective oral medication used in the treatment of psoriasis in combination with nonsteroidal anti-inflammatory and analgesic antipyretic drugs as co-formers obtained through a mechanochemical process.
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Optimisation of the mechanochemical synthesis time of thermoelectric material Mg3Sb2–Mg3Bi2

RSC Mechanochem., 2026, 3,402-409
DOI: 10.1039/D5MR00149H, Paper

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Alena Mikhailova, Aleksandr Markin, Kseniia Shcherbakova, Yurii Kuznetsov, Vlad Dybov, Natalia Tabachkova
The present paper sets out the optimisation of the mechanochemical synthesis process of the thermoelectric material Mg_3.2Sb_1.5Bi_0.45Te_0.05. Optimisation is based on the analysis of phase composition, powder morphology and thermoelectric properties.
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Aerobic mechanochemical RAFT copolymerization of thioctic acid with solid monomers

RSC Mechanochem., 2026, 3,421-428
DOI: 10.1039/D5MR00163C, Paper

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Xiaoyang Shao, Haoyang Feng, Wenjing Liu, Xiaoyu Wang, Chen Wang, Jinhong Han, Zhenhua Wang
Aerobic mechanochemical RAFT copolymerization of thioctic acid with solid monomers was successfully developed to access degradable polymers.
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Sign of mechanochemical curvature governing O2 activation mechanisms and reactivity on rippled supports

RSC Mechanochem., 2026, 3,410-420
DOI: 10.1039/D5MR00147A, Paper

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Sayan Banerjee
2D materials exhibit ripples that generate local curvature, creating a mechanochemical landscape that alters electronic structure. We examine rippled N-doped graphene and quantify how curvature modulates O₂ reactivity at single-atom sites.
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Sono-mechanical activation-assisted proton-catalyzed self-polymerization of AMPS in water: hydrogel formation and its application as a functional additive in ordinary Portland cement

RSC Mechanochem., 2026, 3,429-443
DOI: 10.1039/D5MR00122F, Paper

Open Access

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Kuldeep Rajpurohit, Sabrina A. Shaikh, Ashok K. Pandey, Hemlata K. Bagla
A green, initiator-free method for polymerizing 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS) was developed using low-frequency ultrasound (20 ± 3 kHz) in aqueous solution.
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Mechanochemical base-catalyzed isomerization and deuteration of allylbenzenes

RSC Mechanochem., 2026, 3,338-344
DOI: 10.1039/D5MR00126A, Communication

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Ruoxuan Liu, Xiaochun He, Ruiling Qu, Chengcheng Li, Xiaohong Wang, Xuemei Zhang, Zhong Lian
A mechanochemical, base-catalyzed strategy achieves rapid, metal-free isomerization and deuteration of allylbenzenes, enabling precise CD₃ incorporation under ambient conditions within 15 minutes.
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Mechanochemical synthesis of aspirin nanocrystals for pharmaceutical applications

RSC Mechanochem., 2026, 3,393-401
DOI: 10.1039/D5MR00118H, Paper

Open Access

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G. D. S. Kanchana Garumanna, Ranjit Thakuria, Nadeesh M. Adassooriya
Aspirin nanocrystals were synthesized via mechanochemical milling following the standardization of key processing parameters. The resulting nanocrystallization led to a significant enhancement in the oral bioavailability of aspirin.
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Mechanochemical approach to gallate bioMOFs: efficient synthesis and Cr(VI) removal from aqueous and soil systems

RSC Mechanochem., 2026, 3,378-392
DOI: 10.1039/D5MR00123D, Paper

Open Access

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Alisson Luiz Rocha Balbino, Giovanna Pereira Correia, Gustavo Henrique Correia dos Santos, Priscilla Jussiane Zambiazi, João Paulo da Silva Souza, Bryan Alberto Laura Larico, Denise de Lima Dias Delarica, Kathleen Fernandes, Mara Regina Moitinho, Luciana Pires Rodrigues Betioli, José Marques, Dagoberto de Oliveira da Silva, Paulo Filho Marques de Oliveira, Liane Marcia Rossi
Vibratory ball milling enables the fast, solvent-free synthesis of gallate-based bioMOFs with preserved structure and Cr(VI) adsorption performance.
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Lithium-mediated mechanochemical annulative dimerization of diarylacetylenes for synthesis of 1,4-dihydrodinaphthopentalenes

RSC Mechanochem., 2026, 3,330-337
DOI: 10.1039/D5MR00145E, Communication

Open Access

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Koya M. Hori, Yoshifumi Toyama, Takato Mori, Takumu Nakamura, Yohei Ono, Hideto Ito
The synthesis of dinaphtodihydropentalenes has been achieved by the mechanochemical grinding of lithium wire and diarylalkynes using a ball mill under air. The photophysical/chiroptical properties of the dinaphtodihydropentalene are also discussed.
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Water greatly impacts on the nanomechanical degradation of functionalized surfaces

RSC Mechanochem., 2026, 3,345-356
DOI: 10.1039/D5MR00030K, Paper

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Martin E. Zoloff Michoff, Przemysław Dopieralski, Dominik Marx
Water plays a pivotal role in the mechanochemical degradation of S-anchored PEGylated gold interfaces.
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Amorphous-to-crystalline transformation: a mechanochemical pathway to imine-linked covalent organic frameworks

RSC Mechanochem., 2026, 3,371-377
DOI: 10.1039/D5MR00161G, Paper

Open Access

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Normanda Brown, Yogendra Nailwal, Tyra Blair, Ziad Alsudairy, Qingsong Zhang, Krystal Kennedy, Yi Liu, Xinle Li
This study demonstrates a mechanochemical amorphous-to-crystalline transformation strategy that enables the rapid, ambient synthesis of nine imine-linked COFs with diverse topologies (hcb, sql, kgm, and dia), functionalities, and dimensionalities.
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The role of ball mass, surface, and contact dynamics in mechanochemical reactions

RSC Mechanochem., 2026, 3,357-362
DOI: 10.1039/D5MR00146C, Paper

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Marisol F. Rappen, Justus Mäder, Tino Schwemin, Sven Grätz, Lars Borchardt
This work studies how mass, surface area and contact dynamics affect mechanochemistry using hollow balls and cylindrical tools. Two model reactions are examined: the Finkelstein reaction and the direct mechanocatalysed Suzuki coupling.
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Transition-metal-free/boric acid catalysed mechanochemical synthesis of symmetrical and unsymmetrical azobenzenes: a sustainable approach

RSC Mechanochem., 2026, 3,363-370
DOI: 10.1039/D5MR00133A, Paper

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Tandra Kundu, Saptadwipa Bhattacharjee, Gyan Chandra Pariyar, Bijeta Mitra, Pranab Ghosh
A mechanochemical protocol employing boric acid, an economical and environmentally benign inorganic acid catalyst, enables the synthesis of symmetrical and unsymmetrical azobenzenes from diverse amines.
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Upgrading coal tar products into hypercrosslinked polymers by mechanosynthesis

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00101C, Paper

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A. M. Borrero-López, J. Castro-Gutiérrez, E. Derveaux, W. Marchal, A. Celzard, V. Fierro
Hazardous coal tar products are transformed through solvent free mechanosynthesis into valuable hyper crosslinked polymers, offering promising sustainable solutions for wastewater treatment.
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Synthesis of organic HCl salts via mechanochemical salification and their characterization with 35/37Cl solid-state NMR spectroscopy

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00156K, Paper

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Zachary T. Dowdell, Peyton G. Osborn, Victoria K. Rash, Trisha S. Patel, Alexander M. Perez, Xinsong Lin, Sean T. Holmes, Robert. W. Schurko
Mechanochemical salification enables rapid, stoichiometric control over pharmaceutical salt formation, providing access to hydrates, anhydrous salts, and unusual stoichiometries, using minimal solvent and scalable workflows.
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Electromagnetic milling-promoted steel rod-enabled Sonogashira coupling reactions of aryl halides and terminal alkynes

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D6MR00022C, Paper

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Xinyao Liu, Yanyan Chen, Qiuhong Ma, Meng Yu, Wenjie Guo, Baoju Wang, Qiang Liu, Rujun Yu, Qing Liu, Hui Liu
Electromagnetic milling enables nickel-catalyzed Sonogashira coupling of aryl halides with terminal alkynes under solvent-free, externally unheated conditions, eliminating copper co-catalysts and inert atmospheres.
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Mechanochemical synthesis of Cr3C2: investigating the role of pressure and temperature

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00152H, Paper

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Meet Koshiya, Özgül Agbaba
Chromium carbide (Cr₃C₂) is valued for its outstanding chemical stability, oxidation resistance, hardness, and thermal durability, making it essential for protective coatings, cutting tools, and wear-resistant components.
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Solvent-free continuous flow reduction of aldehydes and ketones via mechanochemistry in a jacketed screw reactor

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00127G, Communication

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Mukesh Purohit, Jagannath Padhi, Amol Kulkarni
We present a simple and efficient solvent-free method for the continuous flow reduction of aldehydes and ketones using sodium borohydride as a reducing agent at room temperature.
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Reimagining sulfohydroxamic acid formation through mechanochemical solid-state activation

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00141B, Paper

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Muhammad Irfan, Pietro Caboni, Andrea Porcheddu, Francesco Basoccu
MgO-mediated milling of sulfonyl chlorides with hydroxylamine hydrochloride enables controlled in situ NH₂OH generation with broad functional-group tolerance and operational simplicity under solvent-free conditions, as a solution-based alternative.
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Why are zeolites harder to make than MOFs? A study of the sodalite system

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D6MR00009F, Paper

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Haochen Wu, Daniel N. Rainer, Simon J. Coles, Samuel J. Page, Stuart L. James
Whilst the mechanochemical synthesis of MOFs is now mature, scaled and commercialised, making zeolites this way is undeveloped. We explore why this is and describe some new solvent-free syntheses of sodalite-type zeolites with high crystallinity.
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Transformation of mechanochemistry from a comminution tool to powerful chemical science: a bibliometric data-driven perspective

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00121H, Perspective

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Matej Baláž
Mechanochemistry has transformed from its beginnings as a comminution and mechanical activation tool to a well-established chemical synthetic tool. This time-resolved bibliographic perspective proves this change.
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Ball milling enables phase-pure synthesis of a temperature sensitive ternary chloride, MgZrCl6

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00114E, Communication

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Christopher L. Rom, Austin M. Shotwell, Sinclair R. Combs, Autumn Peters, Lauren Borgia, Hannah M. Martin, Michael P. Moghadasnia, James R. Neilson, Annalise E. Maughan
Ball milling is a powerful synthetic tool for discovering new inorganic materials.
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