RSC - RSC Mechanochem. latest articles

Ball-Milling Synthesis of α-Bromoacrylates from Solvent-free In-Situ Prepared Ethyl Diethylbromophosphonate

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D6MR00029K, Paper

Open Access

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Marie Caldiero, Jean-Philippe Bouillon, Thomas Castanheiro
A mechanosynthesis of α-bromoacrylates was described from commercially available triethyl phosphonoacetate by using a ball-milling-assisted bromination/HWE one-pot process. Initially, the bromination and the HWE protocols were independently optimized under mechanochemical...
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Electromagnetic Milling-Promoted Steel Rods-enabled Sonogashira Coupling Reactions of Aryl halides and Terminal alkynes

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D6MR00022C, Paper

Open Access

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Xinyao Liu, Yanyan Chen, Qiuhong Ma, Meng Yu, Wenjie Guo, Bao-Ju Wang, Qiang Liu, Rujun Yu, Qing Liu, Hui Liu
Nickel-catalyzed Sonogashira reactions between aryl halides and terminal alkynes have become a powerful method for constructing C(sp²)–C(sp) bonds. Conventional approaches typically required copper co-catalysts, solvents, inert atmospheres, and external heating....
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Ball milling enables phase-pure synthesis of a temperature sensitive ternary chloride, MgZrCl6

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D5MR00114E, Communication

Open Access

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Christopher L Rom, Austin Shotwell, Sinclair Combs, Autumn Peters, Lauren Borgia, Hannah Martin, Michael P. Moghadasnia, James Neilson, Annalise E Maughan
Ball milling is a powerful synthetic tool for discovering new inorganic materials. Inspired by the high ionic conductivity in Li₂ZrCl₆ synthesized via mechanochemistry, we synthesized MgZrCl₆ with a similar method....
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Mechanochemical multicomponent Ugi-azide/post-transformation strategies. Toward more sustainable one-pot diversity-oriented synthesis of complex nitrogen heterocycles

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D6MR00015K, Paper

Open Access

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Alejandro Corona-Díaz, Diana García-García, Sandra C. Ramírez-López, Rocío Gámez-Montaño
Mechanochemical one-pot diversity-oriented synthesis of tetrazoles, bis-, and polyheterocycles via UA-4CR and UA-4CR/post-transformation strategies.
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Mechanoredox radical annulation for the solvent-free synthesis of 2-substituted benzothiophenes

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D6MR00013D, Communication

Open Access

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Ji Ho Song, Eunsil Kim, Do Hyun Kang, Ji Young Hyun, Hwan Jung Lim, Seong Jun Park
A mechanoredox-enabled radical annulation under ball-milling conditions affords 2-substituted benzothiophenes 3 from 2-(methylthio)benzenediazonium salts 1 and alkynes 2.
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Solvent-Free Continuous Flow Reduction of Aldehydes and Ketones via Mechanochemistry in a Jacketed Screw Reactor

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D5MR00127G, Communication

Open Access

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Mukesh Purohit, Jagannath Padhi, Amol Kulkarni
We present a simple and efficient solvent-free method for the continuous flow reduction of aldehydes and ketones using sodium borohydride as a reducing agent at room temperature. By employing a...
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Mechanosynthesis of cocrystals and coamorphous binary drug–drug systems with apremilast core: structural and biological studies

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D6MR00014B, Paper

Open Access

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Marek J. Potrzebowski, Katarzyna Trzeciak, Rafał Dolot, Marta K. Dudek, Ewelina Wielgus, Slawomir Kazmierski, Piotr Paluch, Jiri Brus, Jiri Czernek, Katarzyna Wiktorska, A Lange, I Wadas, K Głowacka
In this paper, we discuss an issue important for understanding the mechanism of forming pharmaceutical binary systems and their safety in specific therapies. The main aim of this article is...
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Transformation of mechanochemistry from a comminution tool to powerful chemical science: A bibliometric data-driven perspective

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D5MR00121H, Perspective

Open Access

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Matej Baláž
Mechanochemistry is advancing rapidly, mainly because it enables necessary chemical transformations that are impossible with solution-based methods. However, it transformed from its beginnings as a comminution and mechanical activation tool...
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Reimagining Sulfohydroxamic Acid Formation through Mechanochemical Solid-State Activation

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D5MR00141B, Paper

Open Access

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Muhammad Irfan, Pietro Caboni, Andrea Porcheddu, Francesco Basoccu
Sulfohydroxamic acids (–SO₂–NHOH), including classical Piloty’s acid derivatives, are key NO/HNO donors and valuable building blocks, but their synthesis still relies on hazardous hydroxylamine solutions and solvent-intensive protocols. Here we...
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Mechanochemical Synthesis of Cr₃C₂: Investigating the Role of Pressure and Temperature

RSC Mechanochem., 2026, Accepted Manuscript
DOI: 10.1039/D5MR00152H, Paper

Open Access

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Özgül Agbaba, Meet Koshiya
Chromium carbide (Cr₃C₂) is valued for its outstanding chemical stability, oxidation resistance, hardness, and thermal durability, making it essential for protective coatings, cutting tools, and wear-resistant components. Conventional Cr₃C₂ synthesis...
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Sono-mechanical activation-assisted proton-catalyzed self-polymerization of AMPS in water: hydrogel formation and its application as a functional additive in ordinary Portland cement

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00122F, Paper

Open Access

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Kuldeep Rajpurohit, Sabrina A. Shaikh, Ashok K. Pandey, Hemlata K. Bagla
A green, initiator-free method for polymerizing 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS) was developed using low-frequency ultrasound (20 ± 3 kHz) in aqueous solution.
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Aerobic mechanochemical RAFT copolymerization of thioctic acid with solid monomers

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00163C, Paper

Open Access

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Xiaoyang Shao, Haoyang Feng, Wenjing Liu, Xiaoyu Wang, Chen Wang, Jinhong Han, Zhenhua Wang
Aerobic mechanochemical RAFT copolymerization of thioctic acid with solid monomers was successfully developed to access degradable polymers.
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Sign of mechanochemical curvature governing O2 activation mechanisms and reactivity on rippled supports

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00147A, Paper

Open Access

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Sayan Banerjee
2D materials exhibit ripples that generate local curvature, creating a mechanochemical landscape that alters electronic structure. We examine rippled N-doped graphene and quantify how curvature modulates O₂ reactivity at single-atom sites.
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Optimisation of the mechanochemical synthesis time of thermoelectric material Mg3Sb2–Mg3Bi2

RSC Mechanochem., 2026, Advance Article
DOI: 10.1039/D5MR00149H, Paper

Open Access

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Alena Mikhailova, Aleksandr Markin, Kseniia Shcherbakova, Yurii Kuznetsov, Vlad Dybov, Natalia Tabachkova
The present paper sets out the optimisation of the mechanochemical synthesis process of the thermoelectric material Mg_3.2Sb_1.5Bi_0.45Te_0.05. Optimisation is based on the analysis of phase composition, powder morphology and thermoelectric properties.
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