RSC - Nat. Prod. Rep. latest articles

Construction of C(sp3)–C(sp3) attached ring motifs in natural product synthesis

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00024J, Review Article

Søren L. B. Møller, Thomas B. Poulsen
A survey of synthetic approaches to saturated C(sp³)–C(sp³) attached ring systems in natural products, with emphasis on direct fragment couplings that enable efficient assembly of complex polycyclic frameworks.
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Fungal polyketide biosynthesis as a platform for designer natural products

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00092K, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pingxin Lin, Zhenhao Fu, Ye Li, Yeo Joon Yoon, Sang Yup Lee
Programming rules of fungal iterative polyketide synthases enable combinatorial biosynthesis and cell-factory engineering to expand polyketide chemical diversity.
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The isolation, biosynthesis, biological profiles and synthesis of the pterocarpans, pterocarpenes and coumestans: isoflavone derivatives with pharmacological utility

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D6NP00007J, Review Article

Liangguang (Jack) Yi, Lorenzo V. White, Martin G. Banwell
The title compounds are three structurally related classes of isoflavone that often act as phytoalexins in the producing plants. This review highlights their biological profiles that make them ongoing targets for synthesis and drug development.
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Synthetic biology for heterologous expression and engineering of fungal polyketide synthases

Nat. Prod. Rep., 2026, 43,401-414
DOI: 10.1039/D5NP00020C, Highlight

Sidharth Jayachandran, Adrian Enrique Gadar-Lopez, Ling Chen, Kasper Krunderup Jakobsen, Coco Xie, Therese Horch, Jay D. Keasling, Pablo Cruz-Morales
Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products.
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Trimeric natural products: structural diversity, biosynthesis, bioactivities and chemical synthesis

Nat. Prod. Rep., 2026, 43,462-496
DOI: 10.1039/D5NP00065C, Review Article

Hidayat Hussain, Satyajit D. Sarker, Lutfun Nahar, Ishtiaq Ahmed
This review highlights structural diversity, biosynthesis, biomimetic synthesis, and biological functions of trimeric natural products. These biosynthetic pathways could lead to the discovery of more bioactive trimers through (bio)synthesis.
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Discovery, engineering, and applications of amino acid and peptide prenyltransferases

Nat. Prod. Rep., 2026, 43,415-426
DOI: 10.1039/D5NP00075K, Highlight

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Florian Hubrich
This review highlights advances in the field of amino acid and peptide prenyltransferases, underscoring their value for chemoenzymatic peptide late-stage functionalization and drug development and showcasing their scope, promiscuity and engineering.
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Biosynthesis of invertebrate-derived natural products: an uncharted territory

Nat. Prod. Rep., 2026, 43,547-575
DOI: 10.1039/D5NP00056D, Review Article

Feng Li, Chengyu Zhou, Yinhao Wang, Mengmeng Yu, Jianhua Ju
Invertebrates are a major source of natural products. Their significant biosynthetic potential, revealed by recent studies, is summarized in this review as a reference for future research.
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Microbial skeletal editing: hints for arene reconstruction from actinobacteria

Nat. Prod. Rep., 2026, 43,518-546
DOI: 10.1039/D5NP00078E, Review Article

Viktoria A. Ikonnikova, Vera A. Alferova, Anastasiya Yu. Frolova, Mikhail S. Baranov, Andrey A. Mikhaylov
This review surveys skeletal editing in actinobacteria, linking enzyme-driven diversification to modern synthetic analogues and outlining biomimetic strategies that translate natural logic into practical chemical tools.
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From diet to defence: ingestion, sequestration, biotransformation, and therapeutic potential of natural products in nudibranch predator–prey interactions

Nat. Prod. Rep., 2026, 43,497-517
DOI: 10.1039/D5NP00058K, Review Article

Lauren Gris, Michèle R. Prinsep
This review focuses on the chemoecological interactions reported between nudibranchs and their marine invertebrate prey, highlighting the ingestion, sequestration and biotransformation of diet-derived natural products and their bioactivities.
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Halogenases and dehalogenases: mechanisms, engineering, and applications

Nat. Prod. Rep., 2026, 43,427-461
DOI: 10.1039/D5NP00055F, Review Article

Jing Luo, Na Li, Jia Wang, Yaojie Gao, Hongzhi Tang, Linquan Bai, Sang Yup Lee, Yaojun Tong
Halogenases and dehalogenases are ubiquitous biocatalysts that mediate halogen incorporation and removal. Synthetic biology is reshaping their catalytic landscapes to unlock new functions and applications.
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Charting the path for L-tyrosine derivatives: from engineering strategies to microbial cell factories

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00091B, Review Article

Li Zhou, Xulei Shi, Hui Jiang, Yuanyuan Xia, Haiquan Yang, Wei Shen, Yu Cao, Xianzhong Chen
Review highlights cutting-edge advances in producing L-tyrosine derivatives via tyrosol, p-coumaric acid, and L-DOPA nodes in E. coli and yeast.
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Glucose 6-phosphate: the diversity of C-methylation in sugar moieties within natural product biosynthesis

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00071H, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ziruo Zou, Michael Müller
Diverse methylation of sugar units by SAM-dependent C-methyltransferases in natural product biosynthesis.
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Highlights of cyanobacterial metabolites reported between 2021–2024

Nat. Prod. Rep., 2026, Advance Article
DOI: 10.1039/D5NP00076A, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Simon Sieber, Elisabeth M.-L. Janssen
This review provides an overview of newly identified cyanobacterial metabolites from 2021 to 2024. The discovery of specific natural products is discussed.
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