RSC - Org. Biomol. Chem. latest articles

Synthetic strategies toward non-fused unsaturated 1,3-oxazines: an update

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00925E, Review Article

Gleb D. Titov, Alena S. Pankova, M S Novikov, Nikolai V. Rostovskii
1,3-Oxazines are important six-membered heterocycles demonstrating diverse biological activities and photochromic properties. Most of the known 1,3-oxazines are benzo-fused; however, in recent decades, numerous reports on the synthesis of monocyclic...
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Precision chemical synthesis of PEGylated IGF2 for potent and selective lysosomal degradation of transmembrane proteins

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00814C, Communication

Boyuan Fan, Xiaoxiong Wei, Weijie Li, Siyi Cui, Jibin Cui, Yicheng Weng, Xiaojun Wang, Wei Cong, Man Pan, Qingyun Zheng, Qian Qu, Yuanyuan Yu
We report a site-specific PEGylation strategy to stabilize insulin-like growth factor 2 (IGF2) as a functional ligand for insulin-like growth factor 2 receptor (IGF2R)-based lysosome-targeting chimera (LYTAC) systems. This chemical...
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Regio- and enantioselective oxidation by CYP108N12: substrate scope and specificity

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00617E, Paper

Julia B. Buczynski, Peter D. Giang, Luke R. Churchman, Stephen G. Bell, James J. De Voss
CYP108N12, supported by cymredoxin, regio- and enantioselectively oxidises para-substituted benzenes.
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Electrophilic alkene sulfenylation with sulfinate esters

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00670A, Paper

Fei Xu, Xuexin Han, Jinyun Li, Hongguang Du, Ning Chen
Sulfinate esters act as sulfur(II) electrophile precursors under HI activation, enabling substrate-dependent electrophilic addition or substitution of alkenes via episulfonium ions.
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A straightforward access to specific bisindole systems related to caulersin

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00692B, Communication

Fei Hu, Yong-tian Yang, Fei Yu, Mei Xu, Sheng Liu
Two sets of starting materials were tested to trigger domino processes involving C3 insertion of indole fragments and C–C migration, thereby enabling the synthesis of a specific bisindole framework related to caulersin.
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Single-step synthesis of 3,5-diazido-1,2,4-triazole: environmentally benign high-performance primary explosives

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00777E, Paper

Sagar Nehe, Srinivas Dharavath
Herein, we report a single-step synthesis of 3,5-diazido-1,2,4-triazole (DATr) from an inexpensive precursor, overcoming the limitations of lengthy synthetic procedures.
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Copper-catalyzed selective 1,2-disulfidation of 1,3-dienes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00721J, Communication

Shuilin Liu, Pu Chen, Ning Liu, Huawen Huang
A copper-catalyzed regioselective 1,2-bis-sulfuration of 1,3-dienes using sulfonyl chlorides and thiols is developed under mild conditions. This efficient method enables single-step installation of diverse sulfur functionalities onto diene skeletons.
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Pyridines with Adamantane Fragments and Their 1,2,4-Triazine Analogues as Anti-Quorum-Sensing Agents, Synthesis and Molecular Docking

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00492J, Paper

Yaroslav K. Shtaitz, Evgeny D Ladin, Kseniya D Krasnoperova, Ivan A Balin, Anton N. Tsmokalyuk, Vasiliy S. Gaviko, Kirill V. Grzhegorzhevski, Dmitry S Kopchuk, Grigory V. Zyryanov
Due to the increasing a resistance of bacterial strains to conventional antibiotics, there is an urgent need to develop alternative antibacterial agents for the treatment of diseases caused by drug-resistant...
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Oxidative Electrochemical Addition of Cyclic 1,3-Dicarbonyls to Alkenes

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00755D, Communication

Ophélie Montiège, Elisa Zuo, Jean-François Brière, Hélène Beucher
An electrochemical radical reaction between cyclic 1,3-dicarbonyls and alkenes is reported herein to give di- and tricyclic dihydrofuran derivatives. This methodolgy proceeds via a direct oxidative addition/cyclization sequence without the...
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The direct access to alkenes from HF2C- or Cl3C-substituted arenes and an organo sodium reagent

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00838K, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Paula Knupe-Wolfgang, Gerhard Hilt
The unprecedented reaction of an organo sodium reagent, generated in a sodium-packed bed reactor, with (difluoromethyl)- or (trichloromethyl)benzene derivatives provided alkenes in acceptable to good yields.
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Metal-free O–H insertion enables access to heterocycle-rich α-carbonyloxy esters

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00779A, Paper

Mohit, Ritika Sharma, Diwan S. Rawat
A metal- and oxidant-free approach for selective O–H insertion of aryldiazoacetates with heterocyclic carboxylic acids leads to the formation of alpha-carbonyloxy esters in up to 93% yield with wide functional group tolerance.
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Exploring synthetic routes to 6-functionalized 4-azaspiro[2.3]hexanes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D5OB01434D, Paper

Wei Huang, Kangqiao Wen, Scott T. Laughlin
Azaspirohexanes are promising scaffolds for the synthesis of piperidine bioisosteres in medicinal chemistry.
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Synthesis of 7-(diethylamino)-chromene-fused quinolines and 7-(diethylamino)-4-amino-3-formyl-coumarin derivatives, structural elucidation, and photophysical properties

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00880A, Paper

Nazmul Hosen, Leah M. Case, Sadira L. Dukette, Nishrenika Pokhrel, Karl J. Wallace
A simple approach to prepare fluorescence dyes with unusual photophysical properties in an array of solvents.
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Stereodivergent access to 5–6–5, 5–6–6, and 5–6–7 fused tricyclic indolizidine cores via ring-size-dependent fragmentation of overbred intermediates

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00837B, Paper

Sushil Kumar Ranjan, Kishor Chandra Bharadwaj, Ganesh Pandey
A rigid overbred precursor enables stereodivergent access to 5–6–5, 5–6–6, and 5–6–7 fused tricyclic nitrogen frameworks via a ring-size-dependent stereochemical switch and strain-release fragmentation.
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Brønsted acid-catalyzed synthesis of benzo[f]indole and naphtho[2,3-b]furan derivatives via an intramolecular cascade isomerization/cyclization/aromatization

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00462H, Paper

Raj Kamal Sahoo, Sourav Ghosh, Kush Mandal, Asadujjaman Nur, Umasish Jana
Herein, we demonstrated a PTSA-catalyzed facile and efficient synthesis of tricyclic benzo[f]indole and naphtho[2,3-b]furan derivatives via a cascade isomerization/cyclisation/aromatisation reaction in good yields.
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Copper-mediated oxidative deconstruction of polyethylene terephthalate via photoinduced ligand-to-metal charge transfer

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00625F, Paper

Guangyao Li, Mingsen Han, Zezheng Leng, Yazhi Deng, Jin Liu, Yu Guo, Bin Yang, Jiazhu Li, Feng Liu, Chang-Cheng Wang
Polyethylene terephthalate (PET) is widely used in daily life due to its excellent properties.
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Replication of chiral α-hydroxy acids via induction and amplification through an enantioenriched cyanohydrin conglomerate

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00652C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tsuneomi Kawasaki, Naoya Takamatsu, Shohei Aiba, Yong Du Kim, Kohei Niikura, So Okumura, Takumi Inoue, Yosuke Tsunomori, Yudai Tanaka, Masaki Kato, Kenji Nemoto, Yuji Tokunaga
Absolute asymmetric synthesis of cyanohydrins has been achieved without an external chiral source. α-Hydroxy acids direct the chiral amplification of their own precursors, establishing a self-replication relevant to the origin of homochirality.
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Synthesis and evaluation of 4-(α-arylvinyl)pyridines as activated linker groups for application in antibody–drug conjugates

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00614K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jack Andrew, James M. Sharpe, Matthew Wallace, Jenny Thirlway, Patrick L. Kerigan Higgs, G. Richard Stephenson, Thomas E. Storr, Christopher J. Richards
The rate of thia-Michael addition of glutathione to 2,6-disubstituted-4-vinylpyridines increased by approximately an order of magnitude by introduction of an α-(4-nitrophenyl) substituent.
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Transition-metal-free three-component synthesis of α-tertiary trifluoromethyl phosphonates from CF3 diazo compounds

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00666C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Shuangming Zhang, Xianda Wu, Yu-Mei Lin, Shaofeng Wu, Guo Tang, Lei Gong, Ablimit Abdukader
α-Trifluoromethylated phosphonates are highly valued in medicinal chemistry and functional materials, yet their efficient synthesis remains challenging. Herein, we report a practical, transition-metal-free strategy for the rapid assembly of this...
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Synthesis of polymethylene-linked bis(cyclobutane-fused chromanones) mediated by gold-photocatalysis

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00903D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Junying Wang, Steven P Nolan, Vladislav Voloshkin, Luigi Cavallo, Sayan Dutta, yuan zhao, Tommaso Ruggiero, Kristof Van Hecke, Bholanath Maity
We report an efficient gold-mediated energy transfer photocatalytic method for the synthesis of polymethylene-linked bis(cyclobutane-fused chromanones) from coumarins and dienes, which undergo intermolecular [2+2] photocycloaddition. The transformation proceeds under mild...
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Azo Compounds as Key Intermediates in the Synthesis of Cinnolines. Recent Advances

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00771F, Review Article

Open Access

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Xabier Jimenez-Aberasturi, Xabier del Corte, Jesús M. de los Santos, Javier Vicario
Over the past decades, azo compounds have emerged as versatile and efficient building blocks for the construction of cinnoline frameworks due to their ready availability, structural diversity, and unique reactivity...
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Palladium-Catalyzed Chelation-Assisted C-H Functionalization of Quinoline Aldehydes to Esters with Mechanistic Insights

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00752J, Communication

Subhash Chandra Ghosh, Anil K Yadav, Dinesh Gopichand Thakur, Mahesh A. Sonawane
We have developed a palladium-catalyzed method for the direct coupling of quinoline-8-carboxaldehyde with aliphatic 1 o , 2 o alcohols and phenols to produce quinoline-8-carboxylate. A catalytically active palladacyclic dimer...
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DMSO as a multifunctional reactant in recent organic synthesis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00576D, Review Article

Anil Rangnath Pawar, Arnab Mandal, Abu Taleb Khan
This review highlights recent advances (2022–2025) in using DMSO beyond a solvent, focusing on metal/metal-free, acid/base-free, photocatalytic, and electrochemical reactions. It emphasizes DMSO as a green C, O, & S synthon in sustainable synthesis.
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Injectable gelatin–PEG hydrogels obtained via cytochrome C-mediated polymerization

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00479B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Andrea Fumaneri, Edoardo Sisti, Alessandro Ajò, H. Samet Varol, Viola Bertolotti, Luigi Menduti, Luisa De Cola
Three injectable gelatin–PEG hydrogels (gelation: 1–2 min) were synthesized via radical polymerization mediated by cytochrome C. The hydrogels showed biocompatibility, biodegradability and sustained release of a drug-mimicking compound.
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Modulation of the optical properties of thiazolinochlorin compounds by the regioselective introduction of aryl(ethynyl) substituents

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00776G, Paper

Takeo Nakano, Shu Miyawaki, Atom Hamasaki, Takashi Takeda
Thiazolinochlorin compounds bearing aryl(ethynyl) substituents at C7 and C8 positions were synthesized via regioselective bromination reactions, and their optical properties were investigated.
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Cu-catalyzed oxidative coupling of alkylarenes with tertiary C(sp3)–H bonds via C–H activation

Org. Biomol. Chem., 2026, 24,5048-5056
DOI: 10.1039/D6OB00723F, Paper

Open Access

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Gang Hong, Pradip D. Nahide, Wahiduddin G. Patel, Marisa C. Kozlowski
Efficient Cu-catalyzed CDC of alkylarenes with tertiary C(sp³)–H Bonds via C–H activation.
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The sulfo-click reaction: expanding the toolbox for bioconjugation and medicinal chemistry

Org. Biomol. Chem., 2026, 24,4971-4991
DOI: 10.1039/D6OB00609D, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Romain Amador, Michael Smietana, Guillaume Clavé
This review surveys the development of sulfo-click chemistry, showcasing its utility as a modular platform for N-acylsulfonamide synthesis, bioconjugation, and drug design.
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HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes

Org. Biomol. Chem., 2026, 24,5022-5027
DOI: 10.1039/D6OB00743K, Communication

Yixi Zhang, Xiaochen Ji, Huawen Huang
Herein, we report a transition-metal-free HBr-catalyzed aerobic CDC reaction of quinoxalin-2(1H)-ones with various heterocycles at room temperature, enabling the efficient construction of biheteroarene scaffolds.
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Imine bond protection by supramolecular encapsulation

Org. Biomol. Chem., 2026, 24,4992-5000
DOI: 10.1039/D6OB00736H, Review Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Kejia Shi, Bradley D. Smith
In aqueous media, an imine bond is hydrolyzed very rapidly, however, it can be protected and stabilized when encapsulated by a suitable host molecule.
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Synthesis of 3′-deoxy-4′-thionucleosides

Org. Biomol. Chem., 2026, 24,5176-5188
DOI: 10.1039/D6OB00725B, Paper

Yoshihiro Natori, Aya Itoh, Momoko Adachi, Hideaki Wakamatsu, Yukako Saito, Asako Kaise, Yuichi Yoshimura
Synthesis of 3′-deoxy-4′-thionucleosides was accomplished utilizing a key tandem S_N2 reaction.
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NMM-promoted decarboxylative C(sp3)–C(sp3) coupling of coumarin-3-carboxylic acids and indolin-3-ones

Org. Biomol. Chem., 2026, 24,5013-5017
DOI: 10.1039/D6OB00593D, Communication

Zhan-Yong Wang, Can Zhang, Xiao-Tian Wang, Xiao-Jin Sun, Yi-Lin Wang, Ting Yang, Chenyang Ma, Ran Xia, Hongxin Liu
A mild, metal-free cascade via Michael addition/decarboxylation affords biologically relevant indolin-3-one-substituted chroman-2-ones with excellent diastereoselectivity, broad scope, and operational simplicity at room temperature.
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Dehydrogenative cycloisomerization–arylation reaction of N-propargyl carboxamides by iodine(III) catalysis using activated sulfoxide

Org. Biomol. Chem., 2026, 24,5171-5175
DOI: 10.1039/D6OB00564K, Paper

Miwa Shoji, Yuki Umakoshi, Yuto Iwanami, Akira Tsubouchi, Akira Yoshimura, Akio Saito
Hypervalent iodine(III) catalysis using an oxidation system that is less expensive than conventional methods enables cycloisomerization–arylation reactions with a wide range of aromatic compounds.
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Anti-adipogenic cyathane diterpenoids from Onychium japonicum

Org. Biomol. Chem., 2026, 24,5037-5047
DOI: 10.1039/D6OB00575F, Paper

Zhen-Yu Yang, Wen-Na Fan, Xiu-Qing Song, Yao-Yue Fan
Onychium japonicum, a Zhuang ethnic medicine, has demonstrated promising anti-obesity potential in preliminary pharmacological studies.
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Synthesis of uniflorol B, a chromanone metabolite of Calea uniflora, and investigation of novel analogues as anti-leishmanial agents

Org. Biomol. Chem., 2026, 24,5018-5021
DOI: 10.1039/D6OB00708B, Communication

Open Access

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Luana Budny Niero, Daniela Pagliara Lage, Eduardo Antonio Ferraz Coelho, Ricardo Andrez Machado-de-Avila, James W. Barlow, Patricia de Aguiar Amaral, Nicolas Gouault
In this work, we report the first synthesis of the anti-leishmanial natural product uniflorol B. Uniflorol B is a chromanone metabolite first isolated from the Brazilian medicinal plant Calea uniflora Less. and possesses anti-leishmanial activity.
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Efficient and metal-free synthesis of functionalized unsymmetrical pyrrolyl–pyridine boron difluoride fluorophores

Org. Biomol. Chem., 2026, 24,5158-5163
DOI: 10.1039/D6OB00705H, Paper

Sirimongkon Aryamueang, Panyawut Ranuman, Nutchapong Suwanwong, Watchara Srimontree, Rung-Yi Lai, Anyanee Kamkaew
A rapid, metal-free strategy enables the synthesis of unsymmetrical BOPP fluorophores with tunable emission and large Stokes shifts, offering a versatile platform for next-generation fluorescent materials.
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Triphosgene-free solid-phase synthesis of urea-containing PSMA-targeting peptides for radiotheranostics: a comparative study

Org. Biomol. Chem., 2026, 24,5087-5096
DOI: 10.1039/D6OB00802J, Paper

Gemma E. Douglas, Madhusudan Vyas, Iman Kavianinia
Prostate-specific membrane antigen (PSMA) is a validated target for prostate cancer imaging and radiotherapy, with most high-affinity ligands incorporating the lysine–urea–glutamate (KuE) pharmacophore.
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Mechanochemical tuning of Pd(BIAN-NHC) allyl/cinnamyl complexes for enhanced cross-coupling

Org. Biomol. Chem., 2026, 24,5078-5086
DOI: 10.1039/D6OB00533K, Paper

Warda Parveen, Farhat Shakeel, Shehzad Muhammad Raffi, Xiangqun Chi, Bo Wang
Air-stable Pd(BIAN-NHC)-cinnamyl/allyl catalysts enable efficient, Suzuki and Buchwald–Hartwig couplings via mechanochemistry with low catalyst loading and highest yield.
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Facile access to thioethers using sodium thiosulfate as the sulfur surrogate under base-mediated conditions

Org. Biomol. Chem., 2026, 24,5113-5118
DOI: 10.1039/D6OB00749J, Paper

Chu-Yun Wu, Cheng-Syun Yang, Tzu-Ying Sung, Ta-Cheng Chen, Po-Chiao Lin, Chien-Fu Liang
Bunte salts were used as sulfur transfer reagents to produce both symmetric and unsymmetric thioethers.
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Synthesis, characterization, and impact of a carbon spacer on the geometry and antibacterial activity of a new series of 1,n-bis(5-cycloalkylsulfenyl-1,3,4-thiadiazole-2-sulfenyl) alkanes (n = 4 and 6)

Org. Biomol. Chem., 2026, 24,5097-5112
DOI: 10.1039/D6OB00750C, Paper

Syarifah Iliya Nor Za'im, Mamduhah Mohamad, Hayedeh Gorjian, Mohd Rafie Johan, Nader Ghaffari Khaligh
Study of the geometry and antibacterial activity of a new series of 1,n-bis(5-cycloalkylsulfenyl-1,3,4-thiadiazole-2-sulfenyl) alkanes.
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Visible-light-driven metal-free iminyl radical cyanation for the synthesis of 3-cyanoindoles

Org. Biomol. Chem., 2026, 24,5119-5129
DOI: 10.1039/D6OB00711B, Paper

Nikita Gupta, Imtiaz Ahmed, Plaban Jyoti Sarma, Shilpa Neog, Gaurisankar Phukan, Vijay Kumar Das
A visible-light-driven method is presented for converting oximes into cyanoindoles through a mild green radical process. It offers a practical, sustainable approach to construct 3-cynao heterocycles, supported by detailed mechanistic and DFT studies.
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Copper-catalyzed trifluoromethylation of vinyl azides with BrCF2CO2K: synthesis of α-trifluoromethyl ketones without external fluoride sources

Org. Biomol. Chem., 2026, 24,5007-5012
DOI: 10.1039/D6OB00710D, Communication

Qinhong Wen, Tianhao Zhang, Xinyu Jia, Yu Wang, Yue Zhao, Taichen Liu, Kai Wei, Zhenghui Kang, Jiuling Li
Cu(I)-catalysed trifluoromethylation of vinyl azides with BrCF₂CO₂K/H₂O produces α-trifluoromethyl ketones without external fluoride. Copper–difluorocarbene pathway enables broad scope, advancing metal difluorocarbene synthetic chemistry.
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From one to two CO2 molecules: controllable divergent synthesis of formate esters and carbonates

Org. Biomol. Chem., 2026, 24,5150-5157
DOI: 10.1039/D6OB00632A, Paper

Qiankai You, Yubing Zhou, Yanwei Ren, Huanfeng Jiang, Chaorong Qi
By precisely modulating reaction conditions, we achieve a controllable reductive functionalization of CO₂, enabling the divergent synthesis of either formate esters or unsymmetrical organic carbonates from CO₂, phenylsilane, and organic halides.
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Copper-catalyzed synthesis of monosubstituted carbodiimides from aromatic amines

Org. Biomol. Chem., 2026, 24,5001-5006
DOI: 10.1039/D6OB00538A, Communication

Yash Dhaduk, Maulik Pethani, Arti Ramani, Hassan Abdul Basheer K V, Hussain Bhukya, Togati Naveen
An efficient copper-catalysed strategy for mild and selective synthesis of carbodiimides from aromatic amines.
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Nicotinic acid-catalyzed synthesis of novel benzothiazoles and benzimidazoles from carbohydrate-derived furfurals: structural, computational, and antimicrobial studies

Org. Biomol. Chem., 2026, 24,5130-5140
DOI: 10.1039/D6OB00468G, Paper

Prajwal Naik C, Saikat Dutta, Chethan B. S., Chethan Prathap K. N., Lokanath N. K., B. C. Revanasiddappa, Nitha Naveen Dsouza
The work reports the high-yielding synthesis of novel benzothiazoles and benzimidazoles from carbohydrate-derived furfurals using nicotinic acid as an innocuous organocatalyst. The products showed promising antibacterial and antifungal activities.
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One-pot multicomponent synthesis of indole-linked fully substituted fused pyrroles

Org. Biomol. Chem., 2026, 24,5064-5077
DOI: 10.1039/D6OB00395H, Paper

Swadhin Swaraj Acharya, Rudranarayan Sutar, Girija Prasad Mishra, Bibhuti Bhusan Parida
Indoles and pyrroles are valued owing to their natural and pharmaceutical abundance and impressive biological profile. In this work a facile route for the synthesis of indole-linked fused pyrroles has been demonstrated.
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Rongalite-mediated hydride-free chemoselective reduction of the CC bond of isatin-derived Michael acceptors

Org. Biomol. Chem., 2026, 24,5164-5170
DOI: 10.1039/D6OB00572A, Paper

Suryakant S. Chaudhari, Chandrakant B. Nichinde, Baliram R. Patil, Anil K. Kinage
Rongalite promotes a metal-, hydride-, and visible-light-free chemoselective reduction of isatin-derived Michael acceptors to 3-substituted 2-oxindoles under ambient conditions, with excellent scalability and favorable green chemistry metrics.
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C-terminally engineered nucleopeptide-based soft materials exhibiting antibacterial and antifungal efficacy against multi-drug-resistant strains

Org. Biomol. Chem., 2026, 24,5189-5199
DOI: 10.1039/D6OB00700G, Paper

Swapnendu Deb, Shreya Ghosh, Sudipta Sarkar, Supratim Bose, Sandipan Chatterjee, Arindam Banerjee
Three self-assembled C-terminally modulated thymine containing nucleopeptides show potential antibacterial and antifungal activities with non-significant cytotoxicity to human cells.
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Palladium-catalyzed migratory allylic sulfonylation of allylic alcohols using sulfonyl hydrazides

Org. Biomol. Chem., 2026, 24,5057-5063
DOI: 10.1039/D6OB00512H, Paper

Xianzhi Yang, Dan Zhao, Yu Liu, Can Zhu
Palladium-catalyzed migratory allylic sulfonylation of allylic alcohols with sulfonyl hydrazides has been established with good chemo- and regioselectivity.
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The enzyme-free regioselective phosphorylation of ribonucleosides is promoted by metal ions

Org. Biomol. Chem., 2026, 24,5141-5149
DOI: 10.1039/D6OB00404K, Paper

Manick Mistri, Biswarup Jash
We show that transition-metal ions promote the regioselective formation of 2′,3′-cyclic ribonucleotides from nucleosides and phosphate via wet-dry cycle. Our findings offer a potential link to the emergence of RNA chain under early Earth conditions.
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Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins

Org. Biomol. Chem., 2026, 24,5028-5036
DOI: 10.1039/D6OB00581K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Sik Lee, Naoko Yoshizawa-Sugata, Hisao Masai, Yoko Yamakoshi
G4-binding tetra-imidazolium porphyrins with longer linkers showed photocytotoxicity with high ¹O₂ generation in the presence of G4.
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Catalytic Synthesis of Saturated Azacycles using Transborylation

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00722H, Communication

Open Access

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Nojus Cironis, Nathan Mcrae, Jack Stubbs, Sarah L. McOnie, Mohammad Babar, Michael Ingelson, Stephen P. Thomas
A simple, catalytic synthesis of pyrrolidines through the intermolecular cyclisation-homologation of azido-butenes was enabled by a hydroboration, 1,2-metallate rearrangement and B-N/B-H transborylation reactoin sequence. Substitution at the C1; C2; C3-positions...
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Rh(III)-catalyzed site-selective hydroarylation of maleimides with 5-aryl-1,2,4-oxadiazole frameworks

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00177G, Paper

Sangepu Karthik, Mettu Dharani, B. Sridhar, Pannala Padmaja, B. V. Subba Reddy
The site-selective C–H functionalization of 5-aryl-1,2,4-oxadiazoles with maleimides is described for the first time using rhodium(III) complex to afford 1,2,4-oxadiazole-succinimide frameworks.
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Recent advances in chemoselective protein desulfurization: from VA-044 to emerging boron, photochemical, iron-catalyzed, and ultrasound methods

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00780E, Review Article

Xiaoyang Ding, Chuntong Li, Xinyan Wang, Lu-Jun Liang
Recently emerged boron-based, photochemical, iron-catalyzed, and ultrasound-induced desulfurization methods offer superior reaction speed and broader functional group compatibility, greatly expanding the scope of chemical protein synthesis.
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Ferric chloride mediated synthesis, photophysical and in vitro anti-Alzheimer's properties of 1H-pyrrolo[2,3-b]pyridin-3-ylmethylphenyl-2-(9H-fluoren-9-ylidene)-1-phenylethan-1-imines

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00406G, Paper

Aravamudhan Subhashini, Pramod Gudigenahally Nagaraju, Ponnusamy Shanmugam
Synthesis and evaluation of the photophysical, anti-Alzheimer's and antioxidant properties of the title compounds obtained from the reaction of Fluorene propargylic alcohols and 2-(7-azaindole-3-methelene) aniline, facilitated by FeCl₃, are reported.
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Covalently linked diphenylethyne bridged meso-aryl 22-oxabenzonorrole–porphyrin/metalloporphyrin dyads

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00631K, Paper

Jyoti Ranjan Kabi, Mangalampalli Ravikanth
The diphenyl ethyne-bridged 22-oxabenzonorrole–Zn(II) porphyrin dyad was synthesized via Pd(0)-catalyzed coupling. TFA demetallation followed by Cu(II) metalation afforded the corresponding Cu(II) dyad.
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An improved guanidine protecting group for the efficient synthesis of GuNA[t-Bu]-modified antisense oligonucleotides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00731G, Paper

Ajaya Ram Shrestha, Junsuke Hayashi, Ryohei Kajino, Ryusuke Hatanaka, Naohiro Horie, Takao Yamaguchi, Satoshi Obika, Tadashi Umemoto
(2,7-Di-tert-butyl-9-fluorenyl)methyloxycarbonyl (DBmoc) is established as a robust guanine protecting group that facilitates efficient and scalable production of GuNA[t-Bu]-modified oligonucleotides.
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A supramolecular assembly of a disulfide linked adamantane-curcumin conjugate with amphiphilic cyclodextrin with redox responsive potential

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00537C, Paper

Open Access

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Roberto Zagami, Chiara Gangemi, Giuseppe Nocito, Alberto Aricò, Maura Monforte, Paola M Bonaccorsi, Antonino Mazzaglia
The synthesis of a novel unsymmetrical disulfide linked adamantane-curcumin conjugate and its supramolecular assembly with amphiphilic cyclodextrin in aqueos dispersion is here reported. Within the nanoassemblies, curcumin derivative was dissolved...
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Recent advances in the total synthesis of coumarin-based natural products

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00463F, Review Article

Mohd Kamil Hussain, Mohd Aqib, Humaira Parveen, Sayeed Mukhtar, Mona O. Albalawi, Kahkashan Begum, Shakir Ahamad, Mohammad Saquib
Critical advances in the total synthesis of coumarin-based natural products are highlighted, emphasizing catalytic and biomimetic strategies, step economy, overall efficiency, and key synthetic challenges in complex coumarin framework construction.
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Metal-dependent pathway selection in Co(III)- and Rh(III)-catalyzed C–H activation–alkyne coupling: a DFT study

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00325G, Paper

Yuanjun Song, Ran Fang, Simeng Qi, Liyuan Meng, Lizi Yang
DFT calculations reveal that Co(III)- and Rh(III)-catalyzed C–H activation–alkyne coupling forms 1,2-dihydrophosphete oxides via sequential alkyne insertion, anti-elimination, cyclization, and protonolysis, with Rh lowering key barriers.
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Creating molecular complexity in the chemoenzymatic synthesis of chlorothricin analogues using tandem Diels–Alderases

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00728G, Communication

Open Access

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Andrew J. Devine, Monserrat Manzo-Ruiz, Catherine R. Back, Katja Zorn, Martin A. Hayes, Paul R. Race, Christine L. Willis
Chemoenzymatic assembly of the pentacyclic core of the antibiotic chlorothricin uses synthetic substrates and the enzymes ChlE3 and ChlL to create 2 rings and 4 new stereocentres. ChlL alone catalyses formation of novel spirocyclic products.
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Transition-metal-free C–H arylation of unactivated arenes with aryl halides enabled by potassium tert-butoxide/gatifloxacin hydrochloride catalyst

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00624H, Paper

Zhirui Hao, Dake Song
Using gatifloxacin hydrochloride as ligands enables potassium tert-butoxide-mediated radical C–H arylation, thereby providing a transition-metal-free and practical approach for the synthesis of diverse (hetero)biaryl skeletons.
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Tunable electrosynthesis of functionalized phenoxazines from alcohols and P4S10

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00744A, Communication

Chenpei Yang, Yanan Li, Jinsong Hu, Yutong Shi, Yan Zhang, Jianan Sun, Peng Qian
An eco-friendly electrochemical three-component synthesis of phosphorodithiolated phenoxazines from phenoxazine, alcohols and P₄S₁₀ is reported under ambient conditions.
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Diversity of dye aggregates: self-assembly of naphthalene-linked chlorophyll dyads dependent on substitution position

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00754F, Paper

Shogo Matsubara, Yusuke Hirose, Tatsuma Ishii, Hitoshi Tamiaki
This work describes the construction of supramolecular chlorophyll aggregates with diverse morphologies via self-assembly of naphthalene-linked chlorophyll dyads, mimicking the structural diversity of photosynthetic light-harvesting antennas.
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Aza-Prins type cyclisation of vinyl bis-sulfide-tethered amines for the collective syntheses of piperidine, indolizidine and isoindolone natural products

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00883F, Communication

Santosh J. Gharpure, Rakhi Yadav, Krishna S. Gupta, Girish P. Kadam
We report a Brønsted acid-mediated inter- and intramolecular aza-Prins cyclisation of vinyl bis-sulfide substituted amines, providing an efficient and highly stereoselective approach to synthesize piperidine, indolizidine, and isoindolone frameworks.
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2-Substituted oxazolyl and thiazolyl amino acids are suitable P1 surrogates for new SARS-CoV-2 main protease inhibitors

Org. Biomol. Chem., 2026, 24,4943-4951
DOI: 10.1039/D6OB00697C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Zijie Liu, Tayla J. Van Oers, Conrad Fischer, Anna Nguyen, Johnson Chew, John C. Vederas
Synthesis of enantiopure heteroazole amino acid building blocks from commercially available materials for incorporation into SARS-CoV-2 M^pro inhibitors as alternatives to the cyclic glutamine P1.
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Steric bulk & solubility provide synthetic access & insight into non-symmetric perylenediimide syntheses

Org. Biomol. Chem., 2026, 24,4914-4918
DOI: 10.1039/D6OB00321D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Brittany R. Pollok, Aubrey R. Caplin, Meghan T. Blakeslee, Sean T. Roberts, Michael J. Rose
Non-symmetric PDIs achieved via sequential imidization: Tailoring first and second imidization conditions through amine selection and solubility enables synthesis of versatile, high-utility molecular derivatives for further synthetic application.
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Photochemical reductive coupling of α-keto esters for synthesizing 2,3-diarylated tartaric acid esters

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00535G, Communication

Yongqin He, Yuzhen Ye, Qiwei Yao, Guogang Tu, Tiansheng Zhao, Hao Qiu, Jia Song, Wanfa Tian, Chunbo Zhang
A metal- and photocatalyst-free method was reported, employing ascorbic acid as a mild reductant for the synthesis of derivatives containing consecutive quaternary carbon centers via the reductive coupling of α-ketoesters.
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Hypervalent iodine-mediated cyclization of N-vinyl amides for the synthesis of 4-functionalized dihydrooxazolines

Org. Biomol. Chem., 2026, 24,4927-4931
DOI: 10.1039/D6OB00685J, Paper

Jiwoo Lee, Suhui Kim, Chang Sung Hong, Bomcha Park, Yeong-Joon Kim, Sungwook Choi, Ki Bum Hong
A hypervalent iodine-mediated heterofunctionalization of N-vinyl amides has been developed using PhI(OAc)₂/KI under mild conditions.
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Oxidative trifunctionalization of indoles with 2-aminobenzyl alcohols: access to iodo-indoloquinoline scaffolds

Org. Biomol. Chem., 2026, 24,4937-4942
DOI: 10.1039/D6OB00682E, Paper

Yaping Zhu, Xinyan Yu, Qinghua Chen, Yong Wang, Liang Zhang, He Zhao, Changjian Zhou, Yong Dai
A facile metal-free synthetic strategy towards indoloquinoline scaffolds via green oxidative functionalization of 2-aminobenzyl alcohols.
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Photocatalytic radical addition/bicyclization of 1,7-enynes with N-sulfonylaminopyridinium salts/sulfamoyl chlorides: access to sulfonamide-containing benzo[a]fluoren-5-ones

Org. Biomol. Chem., 2026, 24,4952-4958
DOI: 10.1039/D6OB00641H, Paper

Zhichao Chen, Zhiyong Jiang, Fengjiao Lv, Xiaolan Xie
A visible light-induced bicyclization of 1,7-enynes with N-sulfonylaminopyridinium salts/sulfamoyl chlorides has been developed. This protocol features mild conditions with a broad substrate scope.
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Synthesis of masked α,β-unsaturated trifluoromethyl ketones via iodine(III)-mediated double decarboxylative trifluoroacetylation

Org. Biomol. Chem., 2026, 24,4830-4834
DOI: 10.1039/D6OB00763E, Communication

Nan Xia, Ming-Chao Li, Jie Zhou, Jun Xu, Hua-Jian Xu
An iodine(III)-mediated double decarboxylative trifluoroacetylation of α,β-unsaturated carboxylic acids with cyclic CF₃-pyruvate acetals under simple thermal conditions is reported.
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Propargyl uridine-based synthesis of glycosylated RNA analogues

Org. Biomol. Chem., 2026, 24,4885-4889
DOI: 10.1039/D6OB00597G, Paper

Jia-Yan Wei, Bo-Xu Gai, Chuan-Shuo Wu, Li Liu, Liang Cheng
We establish a modular click-chemistry platform enabling site-selective synthesis of structurally defined glycosylated RNA mimics at nucleoside and oligonucleotide levels.
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Recent advances in synthesis of tricyclic pyrrole/pyrrolidine-containing scaffolds

Org. Biomol. Chem., 2026, 24,4767-4781
DOI: 10.1039/D5OB01922B, Review Article

Juanjuan Wang, Yuyao Zhao, Bingxian Liu
This review systematically summarizes the synthetic methodologies developed over the past five years for the construction of tricyclic pyrrole/pyrrolidine-containing frameworks, with a focus on transition-metal catalysis and organocatalysis.
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Guanidine-based azines from N-heterocyclic carbene (NHC)-derived selenoureas and diazo compounds: synthesis, structural diversification, and biological evaluation

Org. Biomol. Chem., 2026, 24,4919-4926
DOI: 10.1039/D6OB00548A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dimitrios K. Giannopoulos, Ilias Papantzimas, Spyridon A. Ferikoglou, Efstathios Tonis, Nikolaos V. Tzouras, Athanasios Pseftogas, Fady Nahra, Steven P. Nolan, Aristides G. Eliopoulos, Georgios C. Vougioukalakis
We report a synthetic strategy to guanidine-based azines from NHC-derived selenoureas and functionalized diazo compounds, with broad scope and chromatography-free workup via recyclable PS-PPh₃, showing promising anti-cancer potential.
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Photoenzymatic new-to-nature transformations via electron donor–acceptor complexes

Org. Biomol. Chem., 2026, 24,4752-4766
DOI: 10.1039/D6OB00560H, Review Article

Lei Zhang, Fan Zhou, Jing Wang, Jialuo Zou
This review summarizes recent progress in the development of EDA complex-mediated abiological transformations in photoenzymatic reactions, highlighting their capacity to enable the asymmetric construction of diverse molecular skeletons.
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Metal-free N-arylation of sulfoximines using diaryliodonium salts at room temperature

Org. Biomol. Chem., 2026, 24,4825-4829
DOI: 10.1039/D6OB00638H, Communication

Rajesh K. Marag, Deeksha, Ritesh Singh
A transition-metal-free method for the N-arylation of NH-sulfoximines at room temperature has been developed, offering broad functional-group tolerance and high efficiency.
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Imine-directed Ru(II)-catalyzed ortho-C(sp2)–H amidation of 3-arylquinoxalin-2(1H)-ones via nitrene transfer from acyl/heteroacyl azides

Org. Biomol. Chem., 2026, 24,4901-4913
DOI: 10.1039/D6OB00532B, Paper

Shivani Sapra, Sunil K. Singh, Brajendra K. Singh
Imine-directed Ru(II)-catalyzed regioselective ortho-C(sp²)–H amidation of 3-arylquinoxalin-2(1H)-ones with acyl and heteroacyl azides furnished 36 novel amides with broad substrate scope, late-stage functionalization, and gram-scale applicability.
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Rapidly photocleavable triazene-functionalized nucleotides for DNA sequencing

Org. Biomol. Chem., 2026, 24,4835-4841
DOI: 10.1039/D6OB00577B, Paper

Pingyang Wang, Yumei Shen
A method for the preparation of triazene-functionalized nucleotides and their fast photocleavable application in DNA sequencing are described.
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Substituent effects on photoresponsive nitric oxide release by N-nitrosoaniline derivatives

Org. Biomol. Chem., 2026, 24,4865-4874
DOI: 10.1039/D6OB00679E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Haruka Tsuchiya, Osuke Yoshikawa, Mei Harada, Mikako Ogawa, Yuhei Ohta, Hidehiko Nakagawa, Naoya Ieda
The structure–activity relationship of photocontrollable NO releasers was investigated. It was suggested that the differences in photoreactivity originate from differences in the propensity for transition to the charge transfer (CT) excited state.
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Photo-driven synthesis of N-sulfonylformamidines: a catalyst- and sensitiser-free approach

Org. Biomol. Chem., 2026, 24,4890-4900
DOI: 10.1039/D6OB00595K, Paper

Moitreyee Bhattacharjee, Prodeep Phukan
A sustainable photochemical nitrene-mediated strategy for the sulfonylimination of formamides via white LED-enabled activation of N,N-dibromoarylsulfonamides, yielding a library of N-sulfonylformamidines under mild and operationally simple conditions.
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Azine-fused [6]carbohelicenes: synthesis, crystal structure, stereoisomerism and optical properties

Org. Biomol. Chem., 2026, 24,4842-4851
DOI: 10.1039/D6OB00620E, Paper

Sergey S. Marchenko, Samita J. Sokha, Oleg P. Demidov, Anatoly V. Chernyshev, Anatoly V. Metelitsa, Sergei S. Brig, Ilya V. Prolomov, Michael G. Medvedev, Anna V. Gulevskaya
Novel azine-fused [6]helicenes were prepared. The X-ray structures, UV-vis absorption and fluorescence spectra of the helicenes were investigated and compared to those of the parent [6]carbohelicene.
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Tandem cyclization and defluorinative cyanation of CF3-enynes: mild access to cyano-azulenes

Org. Biomol. Chem., 2026, 24,4820-4824
DOI: 10.1039/D6OB00655H, Communication

Binbin Chen, Wuding Sun, Guoxing Wang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou
A transition-metal-free synthesis directly converts CF₃-enynes to valuable cyano-azulenes via tandem cyclization and defluorinative cyanation. This mild protocol boasts broad functional group tolerance and gram-scale scalability.
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Terpenoid-derived β-ketoesters: acid-induced rearrangements in the homocamphor series

Org. Biomol. Chem., 2026, 24,4875-4884
DOI: 10.1039/D6OB00619A, Paper

Tkachenko Ilya Mikhailovich, Nezamutdinova Kamila Renatovna, Olga A. Lodochnikova, Klimochkin Yuri Nikolaevich
This work describes acid-catalyzed cascade transformations of homocamphor-derived β-ketoesters into [2.2.2]-skeleton fused and embedded lactones.
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Halogen-mediated C2/C3 functionalization of indoles: a concise overview

Org. Biomol. Chem., 2026, 24,4782-4815
DOI: 10.1039/D6OB00635C, Review Article

Mariyaraj Arockiaraj, Rojalini Nayak, Venkatachalam Rajeshkumar
This review highlights halogen-mediated C2/C3 functionalization of indoles using molecular halogens and N-halosuccinimides for diverse bond-forming transformations, offering an efficient platform for sustainable indole functionalization.
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Synthesis of mesoionic carbene-triazole-based Pd(II) complex: promoting C–H activation toward N-aryl carbazoles

Org. Biomol. Chem., 2026, 24,4932-4936
DOI: 10.1039/D6OB00378H, Paper

Puneet Singh Gahlaut, Bhawana Shekhawat, Prem Lama, Barun Jana
This work presents the synthesis of a novel Pd–MIC complex that enables diverse N-aryl carbazoles. Furthermore, nitration and chalcogenation have been introduced as extensions toward potential post-functionalization pathways.
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Racemising 3-aryl-3-hydroxy-2-oxindoles in a Pickering emulsion under acid catalysis and its application to dynamic kinetic resolution

Org. Biomol. Chem., 2026, 24,4816-4819
DOI: 10.1039/D6OB00544F, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jihoon Moon, Shuji Akai, Kyohei Kanomata
3-Aryl-3-hydroxy-2-oxindoles were racemised under acid-catalysis in a water-in-oil Pickering emulsion comprising toluene and aqueous H₂SO₄.
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Co(II) mediated cascade cyclization of unactivated olefins to afford N-alkylacetamided tetrahydropyridazines and dihydropyrazoles

Org. Biomol. Chem., 2026, 24,4852-4864
DOI: 10.1039/D6OB00436A, Paper

Subham Sau, Arunabha Thakur
Co(II) salt catalysed cascade cyclization of unactivated alkenes to afford N-heterocycles without employing external coupling agents under N₂-free conditions.
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N–N Ring Opening of Diazabicyclo[3.1.0]hexanes with Aryl Isocyanates and Isothiocyanates

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00116E, Communication

Stanislav A. Linnik, Alexander Molchanov, Denis V. Solov'ev, Alexander S. Konev, Dar'ya V. Spiridonova, Mariia M. Efremova
Diazabicyclo[3.1.0]hexanes were shown to react selectively with three equivalents of aryl isocyanate to form 2,4-dioxo-N,1,3-triarylhexahydro-1H-pyrimido[1,2-a][1,3,5]triazine-9(2H)-carboxamides. Reaction with aryl isothiocyanates under similar conditions gives N1,N3-diaryldihydropyrimidine-1,3(2H,4H)-bis(carbothioamides). The addition of boron trifluoride etherate...
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Asymmetric α-amination of aldehydes at low catalytic loading: application to the synthesis of solriamfetol and nateglinide

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00769D, Paper

Ronak Mehta, Rohtash Kumar, Avinash Avinash, Chandrakumar Appayee
We have developed a highly efficient asymmetric α-amination of aldehydes using 0.1 mol% nonsilyl bicyclic organocatalyst, delivering broad substrate scope, up to 96% yield and 94% ee, with applications in solriamfetol and nateglinide synthesis.
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Design, synthesis, and evaluation of trisubstituted bicyclo[2.2.2]oct-2-enes as non-classical isosteres of trisubstituted benzenes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00798H, Paper

Chih-Wei Hsu, Wei-Qi Liu, Fang-Jie Shih, Yong-Jin Jheng, Chih-Hui Chou, Yu-Meng Wang, Sung-Fang Chen, John Chu, Woo-Jin Yoo
Substituted bicyclo[2.2.2]oct-2-enes serve as accessible non-classical benzene isosteres, supported by structural and biological studies.
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Palladium-catalyzed synthesis of S-aryl thiocarbamates via desulfurative C–S cross-coupling reaction of dithiocarbamates

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00331A, Paper

Rahul Mondal, Manas Mondal, Amit Saha
A new protocol has been demonstrated here for synthesizing S-aryl thiocarbamates via the desulfurative C–S cross coupling of dithiocarbamate esters with arylsilanes in the presence of a Pd(II) catalyst and a Cu(II) oxidant.
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Synthesis of aza-β-lactams via B(C6F5)3-catalyzed Wolff rearrangement/[2 + 2] cascade cyclization of α-diazoketones with diazenes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00455E, Paper

Weihong Song, YuXiao Ye, Jingdong Wu, Junjie Li, Xiaomei Jiang, Rongbin Zhao, Weiguo Yu, ZiWei Xiang
B(C₆F₅)₃-catalyzed cascade reaction of α-diazoketones and diazenes via Wolff rearrangement/[2 + 2] cyclization yields diverse aza-β-lactams (up to 98% yield) with excellent scalability.
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Self-delivering THPC-modified cytochrome c induces cancer cell apoptosis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00487C, Communication

Zipei Tan, Tao Jiang, Zirun Wang, Ning Zhang, Mingming Ma
THPC modification converts cytochrome c into a self-delivering anticancer protein.
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Experimental and computational insights into the unexpected Type I dyotropic rearrangement within N-clovanylamides synthesised via microwave-assisted SnII-catalysis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00656F, Paper

Antonio Ruano-González, Ana A. Pinto, Dhionne C. Gomes, Rosa Duran-Patrón, Rosario Hernández-Galán, Andrés G. Algarra, Antonio J. Macías-Sánchez, Isidro G. Collado
A Sn(II)-catalysed Ritter synthesis of clovanylamides revealed an interesting Type I dyotropic rearrangement, involving a migrating bromine atom, to explain the unexpected convergence of skeletal isomers.
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Distinct reactivity of aromatic and aliphatic thiols for the efficient synthesis of chromeno[2,3-d]pyrimidine and chromeno[4,3-b]chromene derivatives: mechanistic investigations and reaction scope

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00585C, Communication

Suman Sourabh, Yogesh Bhaskar Singh Tanwer, Raj Rani, Sabyasachi Bhunia, Sanchari Pal, Debjit Das
This study presents three-/two-component cyclization protocol for synthesizing valuable chromeno[2,3-d]pyrimidine and chromeno[4,3-b]chromene derivatives, where aromatic thiols act as nucleophiles and aliphatic thiols serve as reducing agents.
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Bioinspired direct diversification of Pinus densiflora resin via an oxa-Diels–Alder reaction and its anti-neuroinflammatory effects in BV2 microglial cells

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00452K, Paper

Van-Hieu Mai, Seri Choi, Yunhui Che, Gi-Hyeon Seong, Jae Sang Park, Jin-Pyo An, Yun-Sil Lee, Won-Keun Oh
A diversification-driven oxa-Diels–Alder strategy generated structurally unique meroterpenoids from pine resin, yielding compounds with enhanced anti-inflammatory activity in LPS-activated BV2 microglial cells.
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Study of aza-and diaza-cyclotribenzylidenes conformations

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00727A, Paper

Arsène Château, Clement Vigier, Karine Jarsale, Remi Legay, Jean-François Lohier, Jana Sopkova de Oliveira Santos, Thomas Cailly, Frédéric Fabis, Emmanuelle Dubost
The synthesis of both aza- and diaza-cyclotribenzylidene (CTB-1NH and CTB-2NH respectively), cyclotribenzylidenes functionalized with one or two nitrogen atoms replacing methylene bridges is reported, as well as the alkylation and...
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Catalytic regioselective alkylation of oxindoles using diaryl secondary alcohols under homogeneous conditions

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00687F, Paper

Chibisree Elanchezhian, Nandana Mohan, Mrinal Kanti Das, Saikat Chaudhuri
Metal-free alkylation of 2-oxindoles under mild conditions is achieved using DABCO(TfOH)₂ and HFIP. The method enables selective N- and C5-functionalization, providing diverse products in excellent yields with broad substrate scope.
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Metalloradical and photoredox manifolds in manganese photocatalysis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00695G, Review Article

Maulik Pethani, Yash Dhaduk, Shivam Vispute, Anilkumar Kommoju, Shreeya Dave, Arpan Patel, Kishor Padala, Togati Naveen
Visible-light-driven manganese catalysis has emerged as a powerful and sustainable alternative to noble-metal-based photoredox systems.
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Visible-light-driven photocatalyst-free synthesis of N-aryl amino acids

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00643D, Paper

Feng Chen, Zhiqin Zhang, Jianwei Wang, Jiaxi Xu, Hongguang Du, Ning Chen
A photocatalyst-free visible-light three-component coupling enables efficient synthesis of N-aryl amino acids from glyoxylates, anilines, and 4-alkyl DHPs with broad scope and excellent functional-group tolerance.
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