RSC - Org. Biomol. Chem. latest articles

Triphosgene-Free Solid-Phase Synthesis of Urea-Containing PSMA-Targeting Peptides for Radiotheranostics: A Comparative Study

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00802J, Paper

Gemma E Douglas, Madhusudan Vyas, Iman Kavianinia
Prostate-specific membrane antigen (PSMA) is a validated target for prostate cancer imaging and radiotherapy, with most high-affinity ligands incorporating the lysine–urea–glutamate (KuE) pharmacophore. Despite emerging triphosgene-free approaches, current synthetic strategies...
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Total Synthesis of (+)-Cassiol

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00545D, Paper

Badrodin Ayyub Shaikh, Shoba R Tejesvani
Total synthesis of cassiol was accomplished from geraniol in nine steps. Yamamoto epoxide rearrangement was used to establish the chiral quaternary center, while ring closing metathesis was used to construct...
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Facile Access to Thioethers Using Sodium Thiosulfate as the Sulfur Surrogate under Base-Mediated Conditions

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00749J, Paper

Chu-Yun Wu, Cheng-Syun Yang, Tzu-Ying Sung, Ta-Cheng Chen, Po-Chiao Lin, Chien-Fu Liang
In this study, we developed an efficient synthetic method for thioether formation from sodium thiosulfate and organic bromides under transition metal- and oxidand-free conditions. Sodium thiosulfate served as the sulfur...
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Mechanochemical Tuning of Pd(BIAN–NHC) Allyl/Cinnamyl Complexes for Enhanced Cross-Coupling

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00533K, Paper

Warda Parveen, Farhat Shakeel, Shehzad Muhammad Raffi, Xiangqun Chi, Bo Wang
The development of efficient and sustainable catalytic systems for cross-coupling reactions remains a central goal in synthetic chemistry. Building upon established palladium–NHC catalyst platforms we report a novel class of...
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Photochemical Reductive Coupling of α-Keto esters for Synthesizing 2,3-Diarylated Tartaric Acid Esters

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00535G, Communication

Yong Qin He, Yuzhen Ye, Qiwei Yao, Guogang Tu, Tiansheng Zhao, Hao Qiu, Jia Song, Wan-Fa Tian, Chunbo Zhang
A metal- and photocatalyst-free method for reductive homocoupling of α-ketoesters using ascorbic acid as a mild hydrogen source is reported. This approach avoids strong stoichiometric reductants or complex photocatalysts, The...
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Hypervalent Iodine-Mediated Cyclization of N-Vinyl Amides for the Synthesis of 4-Functionalized Dihydrooxazolines

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00685J, Paper

Jiwoo Lee, Suhui Kim, Chang S Hong, Bomcha Park, Yeong-Joon kim, Sungwook Choi, Ki Bum Hong
A hypervalent iodine-mediated heterofunctionalization of N-vinyl amides has been developed using PhI(OAc)₂/KI under mild conditions. This method provides efficient access to 4-aminated and 4-acetoxylated dihydrooxazolines with broad functional-group tolerance, accommodating...
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Propargyl uridine-based synthesis of glycosylated RNA analogues

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00597G, Paper

Jia-Yan Wei, Bo-Xu Gai, Chuan-Shuo Wu, Li Liu, Liang Cheng
We establish a modular click-chemistry platform enabling site-selective synthesis of structurally defined glycosylated RNA mimics at nucleoside and oligonucleotide levels.
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Metal-free N-arylation of sulfoximines using diaryliodonium salts at room temperature

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00638H, Communication

Rajesh K. Marag, Deeksha, Ritesh Singh
A transition-metal-free method for the N-arylation of NH-sulfoximines at room temperature has been developed, offering broad functional-group tolerance and high efficiency.
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Imine-directed Ru(II)-catalyzed ortho-C(sp2)–H amidation of 3-arylquinoxalin-2(1H)-ones via nitrene transfer from acyl/heteroacyl azides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00532B, Paper

Shivani Sapra, Sunil K. Singh, Brajendra K. Singh
Imine-directed Ru(II)-catalyzed regioselective ortho-C(sp²)–H amidation of 3-arylquinoxalin-2(1H)-ones with acyl and heteroacyl azides furnished 36 novel amides with broad substrate scope, late-stage functionalization, and gram-scale applicability.
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Photo-driven synthesis of N-sulfonylformamidines: a catalyst- and sensitiser-free approach

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00595K, Paper

Moitreyee Bhattacharjee, Prodeep Phukan
A sustainable photochemical nitrene-mediated strategy for the sulfonylimination of formamides via white LED-enabled activation of N,N-dibromoarylsulfonamides, yielding a library of N-sulfonylformamidines under mild and operationally simple conditions.
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Synthesis, characterization, and impact of carbon spacer on geometry and antibacterial activity of a new series of 1,n-bis(5-cycloalkylsulfenyl-1,3,4-thiadiazole-2-sulfenyl) alkanes (n = 4 and 6)

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00750C, Paper

Syarifah Iliya Nor Za'ima, Mamduhah Mohamad, Hayedeh Gorjian, Mohd Rafie Johan, Nader Ghaffari Khaligh
Regarding the importance of 1,3,4-thiadiazoles due to their versatile biological activity and for the investigation of the carbon spacer impact on their toxicity and antibacterial activity, a new series of...
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Visible-light-driven metal-free iminyl radical cyanation for the synthesis of 3-cyanoindoles

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00711B, Paper

Nikita Gupta, Imtiaz Ahmed, Plaban Jyoti Sarma, Shilpa Neog, Gauri sankar Phukan, Vijay Kumar Das
Visible-light powered catalysis offers an efficient and environmentally friendly approach to organic synthesis. In this study, we report a photocatalytic iminyl radical cyanation (IRC) of oximes of indoles and related...
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Correction: Assessment of solvent exposure of native cysteines in human Hsp90 using thiol-reactive functional tags

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB90064J, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ya-Xin Xie, Xi-Wei Wang, Xing Zhang, Jia-Long Zhao, Dan Cheng, Yin Yang, Daniela Goldfarb, Xun-Cheng Su
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Oxidative trifunctionalization of indoles with 2-aminobenzyl alcohols: access to iodo-indoloquinoline scaffolds

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00682E, Paper

Yaping Zhu, Xinyan Yu, Qinghua Chen, Yong Wang, Liang Zhang, He Zhao, Changjian Zhou, Yong Dai
A facile and environment-friendly synthetic strategy toward iodo-indoloquinolines with high site-selectivity and atomefficiency is reported, featuring an oxidative functionalization of 2-aminobenzyl alcohols with indoles in the presence of molecular iodine...
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Copper-catalyzed trifluoromethylation of vinyl azides with BrCF2CO2K: synthesis of α-trifluoromethyl ketones without external fluoride sources

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00710D, Communication

Qinhong Wen, Tianhao Zhang, Xinyu Jia, Yu Wang, Yue Zhao, Taichen Liu, Kai Wei, Zhenghui Kang, Jiuling Li
Herein, we disclose a copper(I)-catalysed trifluoromethylation of vinyl azides with BrCF₂CO₂K and water, affording α-trifluoromethyl ketones without an external fluoride source. BrCF2CO₂K serves as both a difluorocarbene precursor and an...
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From one to two CO₂ molecules: controllable divergent synthesis of formate esters and carbonates

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00632A, Paper

Qiankai You, Yubing Zhou, Yanwei Ren, Huanfeng Jiang, Chaorong Qi
The selective transformation of carbon dioxide (CO2) into multiple high-value products from a unified set of starting materials represents a compelling yet underexplored frontier in sustainable synthesis. Herein, we report...
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Rapidly photocleavable triazene-functionalized nucleotides for DNA sequencing

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00577B, Paper

Pingyang Wang, Yumei Shen
A method for the preparation of triazene-functionalized nucleotides and their fast photocleavable application in DNA sequencing are described.
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Substituent effects on photoresponsive nitric oxide release by N-nitrosoaniline derivatives

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00679E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Haruka Tsuchiya, Osuke Yoshikawa, Mei Harada, Mikako Ogawa, Yuhei Ohta, Hidehiko Nakagawa, Naoya Ieda
The structure–activity relationship of photocontrollable NO releasers was investigated. It was suggested that the differences in photoreactivity originate from differences in the propensity for transition to the charge transfer (CT) excited state.
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Terpenoid-derived β-ketoesters: acid-induced rearrangements in the homocamphor series

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00619A, Paper

Tkachenko Ilya Mikhailovich, Nezamutdinova Kamila Renatovna, Olga A. Lodochnikova, Klimochkin Yuri Nikolaevich
This work describes acid-catalyzed cascade transformations of homocamphor-derived β-ketoesters into [2.2.2]-skeleton fused and embedded lactones.
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Halogen-mediated C2/C3 functionalization of indoles: a concise overview

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00635C, Review Article

Mariyaraj Arockiaraj, Rojalini Nayak, Venkatachalam Rajeshkumar
This review highlights halogen-mediated C2/C3 functionalization of indoles using molecular halogens and N-halosuccinimides for diverse bond-forming transformations, offering an efficient platform for sustainable indole functionalization.
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Copper-Catalyzed Synthesis of Monosubstituted Carbodiimides from Aromatic Amines

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00538A, Communication

Yash Dhaduk, Maulik Pethani, Arti Ramani, Hassan Abdul Basheer K V, Hussain Bhukya, Togati Naveen
Carbodiimides, which contain the N=C=N group, are important intermediates in organic synthesis, especially for building nitrogen-containing heterocycles. Traditional methods often need harsh conditions, toxic cyanide sources, or costly catalysts, which...
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Photocatalytic radical addition/bicyclization of 1,7-enynes with N-sulfonylaminopyridinium salts/sulfamoyl chlorides: access to sulfonamide-containing benzo[a]fluoren-5-ones

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00641H, Paper

Zhichao Chen, Zhiyong Jiang, Fengjiao Lv, Xiaolan Xie
A visible light-induced bicyclization of 1,7-enynes with N-sulfonylaminopyridinium salts/sulfamoyl chlorides has been developed. This protocol features mild and metal-free reaction conditions with a broad substrate scope and excellent functional group...
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Synthesis of Masked α, β-Unsaturated Trifluoromethyl Ketones via Iodine(III)-Mediated Double Decarboxylative Trifluoroacetylation

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00763E, Communication

Nan Xia, Ming-Chao Li, Jie Zhou, Jun Xu, Hua-Jian Xu
An iodine(III)-mediated double decarboxylative trifluoroacetylation of masked α, β-unsaturated carboxylic acids with cyclic CF₃-pyruvate acetals is reported. This metal-free protocol employs PhI(OCOMe)₂ as a dual-function decarboxylative reagent to forge the...
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Cationic imidazolium macrocycles enable array-based, site-selective optical detection of peptide phosphorylation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00562D, Paper

Arman C. Garcia, Ria Lian, Parisa Fasihianifard, Lin He, Ryan R. Julian, Veronica Carta, Chia-en A. Chang, Richard J. Hooley
Polycationic imidazolium macrocycles show strong affinity for anionic and hydrophobic peptides, and can be paired with dyes in an arrayed format to enable site- and state-selective optical detection of serine phosphorylation.
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Ketoreductase domain mutagenesis reprogrammes chain-length control in alternapyrone biosynthesis

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00604C, Communication

Inthira Tapeng, Jaiyfungkhong Phakeovilay, Pakorn Wattana-Amorn
Ketoreductase domain mutation in MtAltA produced compounds 1 and 2 instead of alternapyrone, indicating its role in chain-length programming.
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Dual-gated photochromism for both directions of azobenzene isomerization via metal complexation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00702C, Paper

Koji Yamakawa, Masaki Yamamura, Tatsuya Nabeshima
A macrocyclic ligand bearing two azobenzene and terpyridine units forms metal complexes. The trans complex suppresses photoisomerization, whereas the cis complex is completely inert, demonstrating dual-gated photochromism of both azobenzene isomers.
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Bovine serum albumin: an effective and eco-friendly biocatalyst for one-pot, three-component synthesis of valuable imidazole N-oxides in H2O–EtOH medium

Org. Biomol. Chem., 2026, 24,4325-4333
DOI: 10.1039/D5OB01970B, Paper

Koustav Singha, Imran Habib, Pintu Pratihar, Dilip Kumar Maiti, Mossaraf Hossain
A one-pot, three-component reaction procedure for the synthesis of valuable bioactive imidazole N-oxide derivatives, using the biocatalyst BSA with the application of an incubator shaker in a water–ethanol (4:6) solvent mixture, has been developed.
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One-pot click chemistry using hydrazine as an azide surrogate: easy access to 1,2,3-triazole functionalities

Org. Biomol. Chem., 2026, 24,4298-4304
DOI: 10.1039/D6OB00521G, Paper

Muzamil Samad, Mohd Irfan, Riyaz Ahmed, Zaheen Akhter, Vijay Kumar, Parvinder Pal Singh
A green, one-pot CuAAC using phenylhydrazine HCl as azide surrogate in PEG-400/H₂O enables safe, chromatography-free synthesis of 1,2,3-triazoles in high yields with broad scope and late-stage functionalization.
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Base-promoted synthesis of α,β-unsaturated amides via C–N bond formation using α,β-unsaturated acids and isothiocyanates

Org. Biomol. Chem., 2026, 24,4320-4324
DOI: 10.1039/D6OB00514D, Paper

Aditya Rai, Krishna Nand Singh
An efficient metal-free strategy is reported for the synthesis of α,β-unsaturated amides from α,β-unsaturated carboxylic acids with isothiocyanates.
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Scalable mechanochemical synthesis of a cyclic dehydroalanine peptide

Org. Biomol. Chem., 2026, 24,4242-4247
DOI: 10.1039/D6OB00662K, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jamie C. Thuan, Katelyn M. Barron, Jun Ohata
This work identified liquid-assisted mechanochemistry as a more reliable way to synthesize the dehydroalanine-based diketopiperazine derivative.
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Pd(II)-catalyzed oxidative cyclization of amino alcohols with 1,3-cyclohexadiene: a route to fused morpholine derivatives

Org. Biomol. Chem., 2026, 24,4237-4241
DOI: 10.1039/D6OB00613B, Communication

Mao Ye, Xiaoya Zhuo, Xiangwen Tan, Wanqing Wu, Huanfeng Jiang
A Pd(II)-catalyzed aerobic oxidative cyclization of amino alcohols with 1,3-cyclohexadiene has been developed. This protocol enables efficient synthesis of diverse morpholines from cyclic or acyclic dienes under mild conditions.
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Synthesis of azido-modified enamides via CC isomerisation of functionalised Ugi adducts

Org. Biomol. Chem., 2026, 24,4264-4272
DOI: 10.1039/D6OB00513F, Paper

Vladyslav Vereshchak, Sofia Fadieieva, Yevhen Kasianenko, Viacheslav Saraiev, Olena Shvets, Vladimir Musatov, Svitlana Shishkina, Valentyn Chebanov, Alexander Tsygankov
Combining the Ugi-4CR of α,β-unsaturated aldehydes with late-stage azidation as an efficient and selective access to diverse functionalized dehydropeptidomimetics.
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An adenine-based molecular rotor as a fluorescent nucleobase with high brightness

Org. Biomol. Chem., 2026, 24,4334-4341
DOI: 10.1039/D6OB00486E, Paper

Anna A. Pushkarevskaya, Polina N. Kamzeeva, Evgeny S. Belyaev, Vladimir A. Brylev, Alexander A. Lomzov, Andrey V. Aralov
An approach to increasing fluorescence brightness of nucleobases has been developed, and its applicability was demonstrated by a bright adenine-based molecular rotor oxo-Ade^BZT with uniform hybridizing properties.
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Metal-free, iodine/DMSO-promoted oxidative C(sp2)–H difunctionalization: synthesis of aminochalcogenylated indoles

Org. Biomol. Chem., 2026, 24,4342-4350
DOI: 10.1039/D6OB00362A, Paper

Satyajit Pal, Subhankar Sarkar, Tanmay Pramanik, Anindita Mukherjee, Sougata Santra, Grigory V. Zyryanov, Adinath Majee
A metal-free iodine/DMSO protocol enables oxidative difunctionalization of indoles via C(sp²)–H coupling between amines and diphenyl dichalcogenides under mild conditions, affording C(sp²)–N and C(sp²)–S/Se bonds in good yields.
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Total synthesis of γ-tocopherol via asymmetric 1,4-conjugate addition of alkyl Grignard reagents to 2-methyl chromone

Org. Biomol. Chem., 2026, 24,4248-4252
DOI: 10.1039/D6OB00616G, Communication

Ya-Ling Li, Yue Liu, Dong-Mei Yao, Jing-Dong Zhang, You-Cai Xiao, Fen-Er Chen
Cu^I/(S,R)-rev-Josiphos-catalyzed asymmetric 1,4-addition of alkyl Grignard reagents to 2-methyl chromones enabled access to chiral tetrasubstituted chromanones with broad scope, excellent regioselectivity, and up to 97% ee.
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Palladium catalyzed cross-couplings of trans-vinylboranes with alkyl bromides: a reversed-polarity alternative to B-alkyl Suzuki reactions

Org. Biomol. Chem., 2026, 24,4273-4280
DOI: 10.1039/D6OB00314A, Paper

Petros Danielsen Siapkaras, Kristian Sørnes, Jens Mortansson Jelstrup Nolsøe, Filip Ekholm, Eirik Johansson Solum, Marius Aursnes
A variety of trans-alkenyl-9-BBN derivatives have been prepared in situ and then coupled with alkyl bromides by utilizing palladium catalysis with the electron-rich and sterically encumbered tricyclohexylphosphine ligand.
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Metal-coordination-driven self-assembly of 8-hydroxyquinoline–peptide into hybrid nanomaterials for in vitro multimodal synergistic anticancer activity

Org. Biomol. Chem., 2026, 24,4287-4297
DOI: 10.1039/D6OB00498A, Paper

Shengyao Wang, Xin Tian, Xinming Li
Self-assembling hybrid nanomaterials with synergistic chemodynamic, photothermal, and chemotherapy properties were prepared from copper-coordinated conjugates of 8-hydroxyquinoline and a peptide segment.
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Visible light-driven strategies for the synthesis of pyrazole scaffolds: needs, mechanistic insights and sustainable horizons

Org. Biomol. Chem., 2026, 24,4138-4178
DOI: 10.1039/D5OB01676B, Review Article

Nisha, Aman Kumar, Vinod Kumar
Pyrazoles have numerous applications in pharmaceuticals, agrochemicals, and functional materials. This article highlights the developments of visible-light-driven, greener, and sustainable synthetic protocols for pyrazoles.
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NF3 for difluoroamination of tertiary lithium reagents

Org. Biomol. Chem., 2026, 24,4232-4236
DOI: 10.1039/D6OB00301J, Communication

Hong Xu, Jin-Hong Lin, Ji-Chang Xiao
We report a difluoroamination reaction using nitrogen trifluoride (NF₃) as the –NF₂ source, initiated via single-electron reduction by organolithium reagents.
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An imine condensation/1,5-electrocyclization cascade enabled permanent aldehyde–amine coupling through a triazole linkage

Org. Biomol. Chem., 2026, 24,4312-4319
DOI: 10.1039/D6OB00410E, Paper

Yi Li, Cheng-Cheng Wei, Xiao-Jing Tian, Peng Jin, Guo-Juan Song, Licheng Xie, Gong Chen, Mei-Hua Shen, Hua-Dong Xu
Reversible imine condensation is captured by a 1,5-electrocyclization opening and closing cascade to form a robust triazole linkage efficiently and cleanly.
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Visible-light-promoted sulfonimidation of alkenes and alkynes

Org. Biomol. Chem., 2026, 24,4305-4311
DOI: 10.1039/D6OB00451B, Paper

AoYun Lu, Yuqi Chen, Bowen Wei, Xiangning Liu, Qin Xia, Jianbing Deng, Yong Wang, Xiaobing Wan
A visible-light-promoted electron donor–acceptor (EDA) complex enables the sulfonimidation of alkenes and alkynes, featuring a broad substrate scope including challenging electron-deficient substrates.
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Guanine O6 and thymine O4 phosphitylation in oligonucleotide synthesis

Org. Biomol. Chem., 2026, 24,4281-4286
DOI: 10.1039/D6OB00610H, Paper

Manoj Perera, Adikari Eriyagama, Shiyue Fang
LCMS analysis provides direct evidence of side-reaction intermediates responsible for internucleotide bond cleavage and troublesome sequence errors.
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Diazoacetonitrile in modern organic synthesis: recent advances, reactivity, and future directions

Org. Biomol. Chem., 2026, 24,4179-4195
DOI: 10.1039/D6OB00419A, Review Article

Anuj Kumar, Parameswari Akshinthala, Mobashshir Hasan Khan, A. Harinath, Narendra Kumar, Mohd Kamil Hussain, Shakir Ahamad
Diazoacetonitrile is a versatile reagent in organic synthesis. Advances in safe in situ generation enable controlled cycloadditions, X–H insertions, and metal–carbene reactions, giving access to diverse nitrile-containing heterocycles.
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Synthesis of bisindole scaffolds by palladium-catalyzed allylic alkylation of N-aminoindole with ortho-iodoaryl allenes

Org. Biomol. Chem., 2026, 24,4227-4231
DOI: 10.1039/D6OB00447D, Communication

Chenyue Ding, Yuan Yin, Enyu Hu, Huiwen Dong, Yanru He, Shuaijie Wu, Ying Han, Lei Wang
A highly efficient Pd-catalyzed domino allylic alkylation of ortho-iodoaryl allenes with N-aminoindoles has been developed, providing N–N scaffold-containing bisindoles in moderate to good yields.
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A five-year perspective on DMAP as a cutting-edge reagent in heterocyclic ring formation

Org. Biomol. Chem., 2026, 24,4196-4226
DOI: 10.1039/D6OB00261G, Review Article

Murali Mohan Achari Kamsali, Laxman Mahadev Alakonda, Mohammed Mujahid Alam, Ravi Varala
The application of DMAP in heterocyclic ring formations that result in the synthesis of several heterocyclic scaffolds has been thoroughly and critically assessed in this review, covering developments in this field from 2021 to the present.
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SEAr-based reductive arylation of indoles with ketones: skeletal metamorphosis of ketones into aryl architectures

Org. Biomol. Chem., 2026, 24,4253-4263
DOI: 10.1039/D6OB00161K, Paper

Taiki Sakata, Teruhisa Tsuchimoto
We developed the S_EAr-based reductive arylation of indoles with ketones, which uniquely metamorphosed into aromatic skeletons during the reaction.
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Recent advances in synthesis of tricyclic pyrrole/pyrrolidine-containing scaffolds

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D5OB01922B, Review Article

Juanjuan Wang, Yuyao Zhao, Bingxian Liu
This review systematically summarizes the synthetic methodologies developed over the past five years for the construction of tricyclic pyrrole/pyrrolidine-containing frameworks, with a focus on transition-metal catalysis and organocatalysis.
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Simple catalyst system involving boric acid and additives for the direct formation of amides from carboxylic acids and amines

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00437G, Communication

Luc Boisvert, Maddy Whitney, Jasmine N. Mikesell, Kate Jernigan, Sarah Weiss, Miranda E. Roland, Emily K. Chu, Ben Smith, Paige Flentge
A new inexpensive catalyst system that uses boric acid and additives increases the efficiency and sustainability of direct amidation reactions.
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Guanidine-Based Azines from N-Heterocyclic Carbene (NHC)-Derived Selenoureas and Diazo Compounds: Synthesis, Structural Diversification, and Biological Evaluation

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00548A, Paper

Open Access

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Dimitrios K. Giannopoulos, Ilias Papantzimas, Spyridon A. Ferikoglou, Efstathios Tonis, Nikolaos V Tzouras, Athanasios Pseftogas, Fady Nahra, Steven P Nolan, Aristides G. Eliopoulos, Georgios C Vougioukalakis
Guanidine-based azines combine two functional groups in their structure, both of which are widely encountered in medicinal chemistry. Such molecules are accessible, among others, via the versatile reaction of N-heterocyclic...
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One-pot synthesis of N-arylated benzotriazoles and benzotriazinones via in situ diazotization and aryne trapping

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00648E, Paper

Balaji M. Ghodake, Asish K. Bhattacharya
We developed an efficient one-pot synthesis of N-arylated benzotriazoles and benzotriazinones via in situ diazotization of o-phenylenediamine or 2-aminobenzamide with ^tBuONO, followed by aryne trapping from 2-(trimethylsilyl)aryl triflates using CsF.
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Homo- and heterotypic pentameric cyclophanes exhibiting fascinating host–guest binding properties

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00588H, Paper

Open Access

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Osamu Hayashida, Hayato Saruwatari, Syota Minami, Takaaki Miyazaki
Tetraaza[2.2.1.2.2.1]paracyclophane (L) and tetraaza[6.1.6.1]paracyclophane (S), which have larger and smaller cavities, respectively, were utilized to develop cationic cyclophane (CP) pentamers as water-soluble hosts.
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Strategic advances in the synthesis of β-sultams: exploiting a privileged scaffold for sulfur-containing heterocycles

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00651E, Review Article

Qidong Yan, Jiayi Jiang, Shuping Huang, Quan Zhou, Nianhua Luo, Jiapian Huang
This review covers advances in β-sultam synthesis via intramolecular cyclization. Ring-closure strategies enable access to strained β-sultams and functionalization, highlighting their importance in medicinal chemistry and heterocyclic design.
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A β-hairpin mimic built on a fluorinated isoxazoline-β2,2-amino acid as a modulator of Tau protein aggregation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00187D, Paper

Open Access

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Murat Saraç, Julia Kaffy, Kaliroi Peqini, Caterina Vanoni, Alina Wetjen, Lisha Singh, Roland Brandt, Valérie Campanacci, Benoît Gigant, François Giraud, Benoît Crousse, Sandrine Ongeri, Maria Luisa Gelmi, Thierry Milcent
Fluorination of Hsp90-derived peptidomimetics modulates Tau dynamics and highlights the key role of β-hairpin architecture.
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Unexpected pyrazine ring annulation in the Cu-catalyzed reaction of aryl bromides with 1,2-diamines. Synthesis of novel pyrazino[2,3-f]perimidine fluorophores

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00354K, Paper

Andrey L. Dyatlov, Ekaterina A. Filatova, Aleksandr A. Shcherbatykh, Oleg P. Demidov, Anna V. Gulevskaya
The Cu(I)-catalyzed N-arylation reaction of indole (or carbazole) with 6-bromo-1,3-dimethyl-1H-perimidin-2(3H)-one utilizing diamine ligands was accompanied by pyrazine ring annulation.
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Hβ zeolite-mediated sustainable solvent free synthesis of indole-2-carboxylic esters

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00574H, Paper

Krishna Sai Gajula, Sai Teja Avusali, Pragati Rathore, Imran Mohammad, Khairunnisa Begam Mahammad, Sreepriya Vedantam, Narender Nama
A novel and greener approach for the synthesis of indole-2-carboxylic esters using Hβ zeolite as a heterogeneous catalyst under solvent-free conditions has been developed.
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Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00581K, Paper

Open Access

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Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Sik Lee, Naoko Yoshizawa-Sugata, Hisao Masai, Yoko Yamakoshi
G4-binding tetra-imidazolium porphyrins with longer linkers showed photocytotoxicity with high ¹O₂ generation in the presence of G4.
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Enantioselective synthesis of chiral 1,2-oxazinane spiro-oxindoles via carbene-catalyzed [3 + 3] annulation of isatin-derived nitrones with enals

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00603E, Communication

Yu Miao, Yang Xiao, Xulin Han, Yao Chen, Feilong Cao, Hongzhi Zhuang, Chunsheng Lin, Yanli Jin, Jianfeng Xu, Xingkuan Chen
The first NHC-catalyzed enantioselective [3 + 3] annulation for the construction of chiral spiro-oxindole 1,2-oxazinanes has been developed.
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2-Cyanobenzothiazole: a journey from darkness to stardom

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00510A, Review Article

Nathan Broudic, Thierry Besson, Corinne Fruit
Recent advances in bioimaging have made 2-cyanobenzothiazole (2-CBT) a key bioorthogonal reagent. This review summarizes historical and recent progress in the synthesis of 2-CBT derivatives.
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Photoenzymatic new-to-nature transformations via electron donor-acceptor complexes

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00560H, Review Article

Lei Zhang, Fan Zhou, Jing Wang, Jialuo Zou
Recent advances have demonstrated that certain enzymes utilizing photoactive cofactors can be redirected upon light excitation to catalyze reactions entirely unrelated to their evolved functions. Given that charge-transfer interactions between...
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Nicotinic Acid-Catalyzed Synthesis of Novel Benzothiazoles and Benzimidazoles from Carbohydrate-Derived Furfurals: Structural, Computational, and Antimicrobial Studies

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00468G, Paper

Prajwal Naik C, Saikat Dutta, Chethan B. S., Chethan Prathap Kesthur Nataraju, Lokanath Neratur Krishnappagowda, B. C. Revanasiddappa, Nitha Naveen Dsouza
Benzothiazole and benzimidazole derivatives represent important heterocyclic scaffolds with well-established pharmacological relevance. In the present study, a sustainable synthetic approach was developed for the preparation of novel benzothiazole and benzimidazole...
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One-Pot Multicomponent Synthesis of Indole-Linked Fully Substituted Fused-Pyrroles

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00395H, Paper

Swadhin Swaraj Acharya, Rudranarayan Sutar, Girija Prasad Mishra, Bibhuti Bhusan Parida
Indole and pyrroles are appreciated owing to their natural and pharmaceutical abundance and impressive biological profile. Herein, we report green, and sustainable non-templated synthesis indole-linked fully substituted fused pyrroles by...
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Tandem cyclization and defluorinative cyanation of CF3-enynes: mild access to cyano-azulenes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00655H, Communication

Binbin Chen, Wuding Sun, Guoxing Wang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou
A transition-metal-free synthesis directly converts CF₃-enynes to valuable cyano-azulenes via tandem cyclization and defluorinative cyanation. This mild protocol boasts broad functional group tolerance and gram-scale scalability.
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Transition metal-free chemoselective synthesis of C3-styryl functionalized di-/tri-substituted pyrrole derivatives and estimation of their antimicrobial properties

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00594B, Paper

Jyoti, Anshu Singh, Nishant, Sonu, Chandi C. Malakar, Somesh Baranwal, Virender Singh
Base-mediated chemoselective synthesis of C3-styryl-functionalized mono-ester and di-ester substituted novel pyrrole derivatives under ambient conditions has been achieved.
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Racemising 3-aryl-3-hydroxy-2-oxindoles in a Pickering emulsion under acid catalysis and its application to dynamic kinetic resolution

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00544F, Communication

Open Access

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Jihoon Moon, Shuji Akai, Kyohei Kanomata
3-Aryl-3-hydroxy-2-oxindoles were racemised under acid-catalysis in a water-in-oil Pickering emulsion comprising toluene and aqueous H₂SO₄.
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Rongalite-mediated hydride-free chemoselective reduction of C=C bond of isatin-derived Michael acceptors

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00572A, Paper

Suryakant Shivaji Chaudhari, Chandrakant Bhagwan Nichinde, Baliram Raosaheb Patil, Anil Kisan Kinage
A chemoselective and sustainable reduction of C=C bond in isatin-derived Michael acceptors has been achieved using rongalite as an inexpensive hydride-free reductant. The transformation proceeds efficiently in ethanol at room...
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PCl3 or PCl3/SnCl4-promoted fluoroalkylthiolation of arenes with fluoroalkanesulfinyl chlorides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00095A, Paper

Tian-Cheng Zhong, Min Jiang, Jin-Tao Liu
An efficient PCl₃ or PCl₃/SnCl₄-promoted fluoroalkylthiolation reaction of arenes with fluoroalkanesulfinyl chlorides has been developed under mild conditions, affording a series of fluoroalkylthiolated arenes in moderate to high yields.
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Diastereoselective synthesis of 1,4,8-trisubstituted perhydroquinolines as novel κ receptor agonists

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00422A, Paper

Open Access

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Lea Flämig, W. Felix Zhu, Katharina Hoffmann, Constantin Daniliuc, Dirk Schepmann, Frank Glorius, Marcel Bermúdez, Karin Loser, Bernhard Wünsch
κ Agonists with the κ-pharmacophoric ethylenediamine system embedded in a rigid decahydroquinoline scaffold were synthesized and pharmacologically evaluated. Moderate κ affinity was compensated by reduced lipophilicity, leading to high LLE values.
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Re-investigation of the HExxH enzyme DarF reveals a dehydrogenation–epoxidation reaction

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00496B, Communication

Open Access

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Jabal Rahmat Haedar, Nils Böhringer, Gaja Swarna Kumari, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Till F. Schäberle, Chin-Soon Phan
Darobactin A is a potent antibiotic, but the biosynthesis of its derivative, dehydrodarobactin A, remains unclear. Here, we discovered HExxH enzyme DarF catalyzes a dehydrogenation-epoxidation reaction and linked to dehydrodarobactin A biosynthesis.
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C-Terminally Engineered Nucleopeptide Based Soft Materials Exhibiting Antibacterial and Antifungal Efficacy against Drug Resistant Strains

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00700G, Paper

Arindam Banerjee, Swapnendu Deb, Shreya Ghosh, Sudipta Sarkar, Supratim Bose, Sandipan Chatterjee
We report a series of self-assembled thymine-conjugated nucleopeptides with the modulation of C-terminal fatty acyl chains as potent antibacterial and antifungal properties showing non-significant cytotoxicity to human cells. These thymine-conjugated...
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Access to aliphatic ester derivatives via visible-light-induced radical alkoxycarbonylation of unactivated alkenes

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00536E, Communication

Liulin Jiao, Tongtong Zhao, Liu Feng, Hongying Fan, Xue Zhang, Li Hai, Yong Wu, Jian Chen
This protocol employs tetrahydroquinazoline derivatives as alkoxycarbonyl radical precursors for the difunctionalization of unactivated alkenes, affording aliphatic esters.
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Azine-fused [6]carbohelicenes: synthesis, crystal structure, stereoisomerism and optical properties

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00620E, Paper

Sergey S. Marchenko, Samita J. Sokha, Oleg P. Demidov, Anatoly V. Chernyshev, Anatoly V. Metelitsa, Sergei S. Brig, Ilya V. Prolomov, Michael Medvedev, Anna V. Gulevskaya
Novel azine-fused [6]helicenes were prepared in five synthetic steps starting from commercially available 2,3-dihaloazines (2,3-dibromopyridine, 2,3-dichloropyrazine and 2,3dichloroquinoxaline). The X-ray structures, UV-vis absorption and fluorescence spectra of the helicenes were...
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Identification of two multifunctional P450 enzymes for biosynthesis of sesteraltererol-type sesterterpenoids

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00650G, Communication

Yue Liu, Zhuo-Jia Gan, Zhong-Yuan Zhang, Huan Zhao, Shao-Yang Li, Gao-Qian Wang, Guo-Dong Chen, Takayoshi Awakawa, Zhi-Qin Cao, Jian-Ming Lv, Dan Hu, Hao Gao
Nine sesteraltererol-type sesterterpenoids, including seven new compounds, were identified via heterologous expression of the sesteraltererol synthase gene aasA and two novel multifunctional P450 enzyme genes aasE and aasB in A. oryzae NSAR1.
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Practical and scalable access to halogenated 1,4-thiazines through a domino Morin-rearrangement/halogenation of N,S-acetals and their arylation based on Suzuki–Miyaura coupling

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00454G, Paper

Fanny Danton, Kouceila Abdelli, Mohamed Othman, Ata Martin Lawson, Hassan Oulyadi, Sergiu Shova, Ján Moncol, Alina Ghinet, Adam Daïch
1,4-Thiazine frameworks bearing a halide X (X = I, Br or Cl) at the α-position of their sulfur atom were prepared in domino Morin-Rearrangement end/or Halogenation in one or two steps, followed by their arylation based on Suzuki-Miyaura coupling.
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Visible-light-driven eosin Y catalyzed arylation of alkenes with formate salt

Org. Biomol. Chem., 2026, 24,4121-4126
DOI: 10.1039/D6OB00414H, Paper

Yan Huang, Jiao Qin, You-Xiang Guo, Li-Rong Chen, Tao Long, Lan-Ying Xu, Qian Zhang
Herein, we reported a visible-light-driven photocatalytic system that employs eosin Y and formate salt to achieve selective arylation of alkenes with aryl iodides under mild and metal-free conditions.
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Iron-catalyzed decarboxylative cyanoalkylation of α-fluoroacrylic acids

Org. Biomol. Chem., 2026, 24,4115-4120
DOI: 10.1039/D6OB00480F, Paper

Hai-Pin Zhou, Yi-Mei Wu, Qing-Ya Zhao, Lin-Yu Zhang, Xin-Ru Hu, Juan-Juan Liu, Xiao-Yu Lu
Herein, an iron-catalyzed decarboxylative coupling of α-fluoroacrylic acids with cycloketone oxime esters is developed.
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Stereocontrolled spirocyclization of exo-glycals with arylamines for the synthesis of (1S)-spiro-tetrahydroquinoline glycosides

Org. Biomol. Chem., 2026, 24,4080-4085
DOI: 10.1039/D6OB00392C, Paper

Po-Yen Chen, Yi-Ting Chiang, Chun-Hung Lin, Min-Tsang Hsieh, Hui-Chang Lin
We report herein a ZnCl₂-promoted coupling of exo-glycals and arylamines that proceeds via a tandem dehydrative amination/hydration/spirocyclization sequence for the stereospecific synthesis of (1S)-spiro-tetrahydroquinoline glycosides.
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Photoredox-catalyzed synthesis of trifluoromethylated benzimidazo-fused heterocycles

Org. Biomol. Chem., 2026, 24,4097-4103
DOI: 10.1039/D6OB00435K, Paper

Zi-Rui Kuang, Shu-Yao Feng, Qian Yan, Chen-Xi Zhang, Jiang-Sheng Li, Zhi-Wei Li
Photoredox trifluoromethylation/cyclization of N-allylbenzimidazoles gives six-membered rings and, with homoallyl, unprecedented seven-membered rings using Togni's II or Langlois reagent.
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Cobalt-catalyzed reductive carboxylation of pyridines with CO2via pyridylphosphonium salts

Org. Biomol. Chem., 2026, 24,4034-4038
DOI: 10.1039/D6OB00565A, Communication

Yucheng Zhao, Hanxuan Wu, Shibiao Tang, Bin Li, Baiquan Wang
Cobalt-catalyzed formal carboxylation of the C4–H bond of pyridines with CO₂ has been developed using a one-pot, two-step method via pyridylphosphonium salts and applied to the late-stage C–H bond carboxylation modifications of drug molecules.
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Synthesis of substituted N-heterocycles via a cascade of Michael addition, double cyclization and air oxidation

Org. Biomol. Chem., 2026, 24,4044-4049
DOI: 10.1039/D6OB00591H, Communication

Hunmoina Phukon, Bikoshita Porashar, Ankita Pradhan, Anil K. Saikia
An efficient synthesis of α-carbolinones and α-carbolines from 2-(2-aminophenyl)acetonitriles and alkyl/arylidene malonates and 2-benzylidene-3-oxopentanoates mediated by Cs₂CO₃ in excellent yields has been developed.
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Palladium-catalyzed direct amination of N-(quinolin-8-yl)-1H-indole-3-carboxamides

Org. Biomol. Chem., 2026, 24,4039-4043
DOI: 10.1039/D6OB00431H, Communication

Xiaolong Wang, Yan Cao, Linqi Wang, Jianwei Wang, Jun Ying
A palladium-catalyzed C–H bond cleavage and amination of indoles with di-tert-butyldiaziridinone has been developed for the rapid construction of 2-amino indole skeletons.
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Light mediated asymmetric approaches towards alkene difunctionalization

Org. Biomol. Chem., 2026, 24,3999-4009
DOI: 10.1039/D6OB00441E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Carolina Gimbert-Suriñach, Roser Pleixats, Albert Granados, Adelina Vallribera
This review summarizes recent advances in asymmetric difunctionalization protocols of alkenes. Particular emphasis is placed on modern strategies based on photoredox/metal dual catalysis, bifunctional catalysts, and chiral radical precursors.
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Synthesis of cyanodifluoromethylselenylated isocoumarins enabled by a p-CF3BnSe(O)CF2CN/Tf2O reagent system

Org. Biomol. Chem., 2026, 24,4029-4033
DOI: 10.1039/D6OB00469E, Communication

Jialiang Wu, Meiling Tian, Jiaxin He, Lingzhi Xu, Xiangyu Zhan, Hui Zhao, Yunfei Du
p-CF₃BnSe(O)CF₂CN/Tf₂O enables efficient synthesis of 4-(cyanodifluoromethylseleno)isocoumarins from 2-alkynylbenzoates via formation of electrophilic selenonium species, followed by cyanodifluoromethylselenolation and lactonization.
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Chemo-, regio- and stereoselective synthesis of (E)-γ,γ-diarylvinylphosphonates from α-hydroxyallylphosphonates in TFA

Org. Biomol. Chem., 2026, 24,4104-4114
DOI: 10.1039/D6OB00158K, Paper

Babak Kaboudin, Abolfazl Yadghybi, Hikaru Yanai, Haruhiko Fukaya, Tianjian Zhang, Yanlong Gu
We developed a novel method for selective synthesis of (E)-γ,γ-diarylvinylphosphonates through chemo-, regioselective dehydrative arylation reaction in TFA. The detailed DFT calculations brought about a good understanding of the reaction pathway.
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A copper-catalyzed reductive cross-coupling reaction of aryl chlorides and aryl bromides

Org. Biomol. Chem., 2026, 24,4022-4028
DOI: 10.1039/D6OB00403B, Communication

Jingyu Wang, Xiongfei Ou, Wenxin Fang, Tao Wang, Jingxun Yu
In this study, we report a copper-catalysed reductive electrophilic cross-coupling reaction that enables the direct formation of C–C bonds between aryl chlorides and aryl bromides under reductive conditions.
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Brønsted acid catalyzed multicomponent synthesis of N-arylindole and N-arylbenzo[e]indole

Org. Biomol. Chem., 2026, 24,4086-4090
DOI: 10.1039/D6OB00598E, Paper

Muhammad Kamran Farooqi, Shou-jin Xiao, Zhen Liu, Minghao Li
Brønsted acid-catalyzed multicomponent reactions involving anilines, 4-hydroxycyclohexanone or 2-tetralone, and 2,2-dimethoxyacetaldehyde were developed, which afforded both C2- and C3-unsubstituted indole derivatives in moderate to good yields.
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Studies directed toward the synthesis of 4-deoxy-10-oxodihydrobotrydial, a naturally occurring botryane

Org. Biomol. Chem., 2026, 24,4091-4096
DOI: 10.1039/D6OB00334F, Paper

Kalpesh Ananda Khude, Tushar Kanti Chakraborty
A concise strategy is developed to construct the structurally challenging [6,5,6]-fused tricyclic framework of sesquiterpenoid fungal metabolites, botryanes, using a Ti(III)-mediated radical cyclization protocol.
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Mild PIFA-mediated synthesis of benzo[4,5]thiazolo[3,2-a]indoles via oxidative cyclization

Org. Biomol. Chem., 2026, 24,4062-4068
DOI: 10.1039/D6OB00393A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Xinya Liu, Christine Tran, Olivier Provot, Pascal Retailleau, Abdallah Hamze
A room-temperature PIFA-mediated oxidative cyclization enables rapid synthesis of benzo[4,5]thiazolo[3,2-a]indoles. The method is broad in scope (28 examples) and enables late-stage diversification and access to bioactive scaffolds.
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Crab-shaped tridentate HoQ-Sulidines as bifunctional anionic ligands: empowering asymmetric addition reactions of indoles with β,γ-unsaturated α-ketoesters

Org. Biomol. Chem., 2026, 24,4010-4015
DOI: 10.1039/D6OB00442C, Communication

Zi-Hong Hu, Xiong-Wei Liu, Wen-Xiu Geng, Ning Wang, Zhen Yao, Rui-Rui Li, Wen-Hui Zhang, Xiong-Li Liu
The new tridentate ligands could serve as anionic ligands upon deprotonative activation, forming a highly enantioselective catalyst.
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Synthesis of 2-aminobenzothiazole substituted indoles via DBU catalyzed addition of indoles and benzothiazolimines

Org. Biomol. Chem., 2026, 24,4069-4073
DOI: 10.1039/D6OB00152A, Paper

Xiang-jia Song, Ya-xiong Wang, Xin-sheng Geng, Jing-jing Zhang, Yu Yang, Min-min Zhang, Hong-feng Yu, Ning-ning Zhao
A DBU-catalyzed Mannich reaction between indoles and benzothiazolimines has been developed, providing an efficient and practical approach to access a series of 2-aminobenzothiazole substituted indoles with potential pharmaceutical relevance.
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Asymmetric oxidative rearrangement of tetrahydro-β-carbolines catalyzed by anionic stereogenic-at-cobalt(III) complexes

Org. Biomol. Chem., 2026, 24,4074-4079
DOI: 10.1039/D6OB00260A, Paper

Bin-Bin Song, Zhen-Jiang Yu, Zi-Mu Liu, Qiongqiong Zhu, Hua-Jie Jiang, Chuan-Zhi Yao, Jie Yu
An asymmetric oxidative rearrangement of tetrahydro-β-carbolines catalyzed by anionic stereogenic-at-cobalt(III) complexes has been developed.
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Visible-light-induced photochemical synthesis of spirooxindoles comprising carbocyclic scaffolds

Org. Biomol. Chem., 2026, 24,3988-3998
DOI: 10.1039/D6OB00460A, Review Article

Tanzina Firdoushi Borbhyuan, R. T. Starthring, Sachidulal Biswas, Biplob Borah, L. Raju Chowhan
This article provides a brief overview of the recent progress achieved in the photochemical synthesis of various spirooxindole motifs featuring carbocyclic scaffolds.
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Photo-induced thio/selenocyanation-annulation-rearrangement of indole-tethered 1,6-enynes

Org. Biomol. Chem., 2026, 24,4016-4021
DOI: 10.1039/D6OB00481D, Communication

Xueli Wang, Lijun Li, Qinqin Yan, Zhenyi Wang, Zexuan Liu, Jingyi Chen, Zhong-Quan Liu, Zejiang Li
The photo-induced thiocyanation/selenocyanation-cyclization-rearrangement of indole-tethered 1,6-enynes to access diverse thiocyanated/selenocyanated bicarbonyl pyrrolo[1,2-a]indoles is demonstrated.
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Connecting the mechanistic steps of cyclic dipeptide formation by a proton-transfer network: pH, temperature, pressure, and nuclear quantum effects

Org. Biomol. Chem., 2026, 24,4050-4061
DOI: 10.1039/D5OB01815C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pimjai Pimbaotham, John K. Villanueva, Siriporn Jungsuttiwong, Masanori Tachikawa, Robert K. Szilagyi
The complete potential energy surface of cyclic dipeptide formation is developed including pH and nuclear quantum effects from density functional theory calculations as a continuation of our peptide condensation investigations.
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Palladium-Catalyzed Migratory Allylic Sulfonylation of Allylic Alcohols Using Sulfonyl Hydrazides

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00512H, Paper

Xianzhi Yang, Dan Zhao, Yu Liu, Can Zhu
The unique electronic properties of the sulfonyl group endow allylic sulfones with particularly value as synthetic intermediates in organic chemistry. Their relevance could also be reflected by the fact that...
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Synthesis of mesoionic carbene-triazole based Pd(II) complex: promoting C-H activation toward N-aryl carbazoles

Org. Biomol. Chem., 2026, Accepted Manuscript
DOI: 10.1039/D6OB00378H, Paper

Puneet Singh Gahlaut, Bhawana Shekhawat, Prem Lama, Barun Jana
Here, we report a triazolylidene based mesoionic carbene (MIC) Pd(II) complex as an efficient catalyst for the synthesis of N-aryl carbazoles via intermolecular C-H amination reaction. The developed system shows...
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One-step synthesis of Zolpidem and its analogues via visible light induced coupling of imidazo[1,2-α]pyridines with 2-bromoacetamides

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00267F, Paper

Shiyu Zhang, Min Li, Yuanjiu Xiao, Yangjianyun Zhang, Peng Deng, Tao Wu, Chun Xia, Wei Deng, Ze Tan
A highly simple and efficient method for synthesizing the drug Zolpidem and its analogues via the coupling of 2-phenylimidazo[1,2-α]pyridines with 2-bromoacetamides under blue LED irradiation has been developed.
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DFT investigation of the 2-aminothiazole-catalyzed five-component reaction of CO2/amines/aldehydes: multi-species synergistic activation and chemoselective control in N-methylation

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00185H, Paper

Xue Zhang, Qin Yu, Ying Zhou, Hua Zhi, Weiwei Gu, Li Li, Jiyang Zhao
The 2-aminothiazole catalyst acts as a synergistic hub coordinating reactive species, modulating reactivity and building a chemoselective methylation network.
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Synthesis of spirooxindoles by the catalytic tandem reaction of 2-arylidene-1,3-indanediones with 2-(2-oxoindolin-3-yl)malononitriles

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00433D, Paper

Peng-Xin Guo, Da-Ming Du
A facile synthesis of spirooxindoles bearing a 3-oxoisobenzofuran-1(3H)-ylidene motif was developed via a tandem Michael addition/cyclization reaction between 2-arylidene-1,3-indanediones and 2-(2-oxoindolin-3-yl)malononitriles catalyzed by K₂CO₃.
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Chiral recognition of organoselenium compounds: an update

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00355A, Review Article

Amanda Goldbeck Gerbaudo, Stella Quadros Fernandes, Danilsa Elisa Sorte Quicaxiamo, Márcio Santos Silva
This review summarizes analytical strategies for chiral recognition of organoselenium compounds, highlighting chromatography, circular dichroism, NMR spectroscopy, fluorescence sensing, and X-ray crystallography.
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Electrocyclization of arylvinyl β-hydroxyacetonitrile to substituted cyanomethyl indene derivatives

Org. Biomol. Chem., 2026, Advance Article
DOI: 10.1039/D6OB00526H, Paper

Amit Kumar, Jagadeesh Babu Nanubolu, Gangarajula Sudhakar
An easy method for accessing indene carboxylic acid and its derivatives has been developed from arylvinyl β-hydroxyacetonitriles in the presence of Lewis acids.
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