RSC - RSC Pharm. latest articles

PLGA and Eudragit-based long-acting microspheres for Parkinson's disease management

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00029K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Deepa D. Nakmode, Haripriya Koppisetti, Weranga Rajapaksha, Yunmei Song, Sanjay Garg
A long-acting PLGA/Eudragit microsphere formulation was developed to replace frequent oral dosing for Parkinson's disease. It successfully delivered hydrophilic pramipexole, achieving sustained release for up to 18 days with excellent syringeability.
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Marburg self-amplifying mRNA-lipid nanoparticle vaccine: differential effects when co-formulated with Toll-like Receptor agonists

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00134C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mhd Anas Tomeh, Gillian Hoover, Sarah Horst, Erik de Leeuw, Murty Chengalvala, Robin Shattock, Allan Watkinson
Schematic representation of Marburg saRNA-LNP vaccine formulations and the type of targeted receptors.
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Hapten-conjugated polymeric nanocarriers produced by Flash NanoPrecipitation induce small molecule-specific antibodies in vivo

RSC Pharm., 2026, Accepted Manuscript
DOI: 10.1039/D6PM00082G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mojhdeh Baghbanbashi, Ryan Burnett, David Gooden, Frank Vago, Herman F Staats, Brandi T Johnson-Weaver, Kurt Ristroph
Vaccines that induce antibodies specific against small molecules are desirable for a range of applications, including as a tool against the opioid epidemic. Many small molecules are not immunogenic due...
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Nanographene Oxide Enables Activity-Preserving Immobilization and Enhanced Stability of Galactose Oxidase

RSC Pharm., 2026, Accepted Manuscript
DOI: 10.1039/D6PM00162A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Junyoung Jung, Abhishek Sahu, Giyoong Tae
Enzyme-mediated generation of reactive oxygen species (ROS) has attracted considerable interest for cancer-related applications. However, the biomedical use of oxidase enzymes is often limited by their intrinsic instability and rapid...
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Lipid Phase Organization Controls Drug Partitioning and Release Across Lipid Nanocarriers

RSC Pharm., 2026, Accepted Manuscript
DOI: 10.1039/D6PM00126B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jader Pires, Lucas R De Souza, Bianca B Fontanezi, Sebastião Mendanha, Eliana Lima
Understanding how lipid organization governs drug incorporation and release across nanocarrier platforms remains a central challenge in the rational design of lipid-based delivery systems. Here, lipid nanoparticles (LNP), liposomes (LIP),...
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Dynamic vapor sorption for quality assessment of pharmaceutical coatings: a case study in enteric protection

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00129G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jesús Alberto Afonso Urich, Michael Piller, Anna Sophie Neubauer, Anna Fedorko, Raymar Andreina Lara García
Combining DVS, OCT, and acid-stage dissolution testing enables a multidimensional evaluation of enteric coatings, linking moisture permeability and coating structure to acid resistance supporting Quality by Design (QbD) principles.
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Development of betaine–aloe vera–gelatin hydrogel formulation for the treatment of burn wounds

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00049E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Rohan Dattatray Londhe, Shikha Tripathi, Obulapathi Ummadisetty, Anurag Kumar Singh, Deepak Chouhan, Avanish Singh Parmar, Vinod Tiwari
Burn wounds present a significant clinical challenge, often leading to prolonged healing, infection, and substantial scarring.
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A modelling-based comparison of IVRT and synthetic-membrane permeation for early formulation screening

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00035E, Paper

Open Access

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Yongrui Xiao, Chunlin Chen, Yu Zhang, Dimitrios Tsaoulidis, Tao Chen
IVRT release rates (6 h, nylon membrane) correlate strongly with IVPT flux (30 h, Strat-M) across fifteen ibuprofen poloxamer-407 formulations (Pearson r = 0.95, R² = 0.92), supporting IVRT for early formulation screening.
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Dual-adjuvant mucosal vaccine leveraging mast cell and TLR9 agonists for protection against poxvirus infection

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D5PM00380F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Connor T. Murphy, Grace L. Williamson, Luis Ontiveros-Padilla, Aaron T. Hendricksen, Brandi T. Johnson-Weaver, Hae Woong Choi, David M. Gooden, Santhosh Kalpathy, Alexandra M. Lopez, Erik S. Pena, Jacob M. Bachelder, Rani S. Sellers, Soman N. Abraham, Herman F. Staats, Kristy M. Ainslie
A novel, mast cell activating small molecule was combined with the FDA-approved adjuvant, CpG, to produce an effective dual-adjuvanted mucosal vaccine formulation for orthopoxviruses.
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The interplay between cationic peptide sequence, siRNA and electrolyte: formulating lipopolyplexes in NaCl solution affords nanocomplexes with exceptional levels of gene silencing

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00042H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lili Cui, Laila Kudsiova, Frederick Campbell, David J. Barlow, Ann E. Terry, Yining Ma, Najet Mahmoudi, Helen C. Hailes, Alethea B. Tabor, M. Jayne Lawrence
Formulating siRNA lipopolyplexes in NaCl solution gives large, multilamellar complexes with high levels of gene silencing in the presence of serum.
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Nanoparticle vaccine formulations for dengue virus

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00015K, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Connor T. Murphy, Kristy M. Ainslie
Dengue virus (DENV) is one of the most prevalent mosquito-borne pathogens, with almost half of the global population at risk of infection.
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Design and development of niacinamide lipid and polymeric nanoparticles and in vitro permeation studies using human epidermis

RSC Pharm., 2026, Advance Article
DOI: 10.1039/D6PM00089D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dimitra Bompou, Emanuela Di Biase, Alexandra Sarika, Efstathia Triantafyllopoulou, Natassa Pippa, Dimitrios M. Rekkas, Paraskevas P. Dallas
Design and development of niacinamide nanoparticles using Design of Experiments.
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