RSC - Org. Chem. Front. latest articles

Recent Advances in Light-Mediated Dearomative Fun ctionalization of Naphthalene and Its Derivatives

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00701E, Review Article

Quan Wang, Bin Feng, Jiahong Li
Photocatalysis, with its mild conditions, excited state mechanisms, and precise site selectivity, has emerged as a key technology for the dearomatization of fused polycyclic arenes. Naphthalene exhibits intrinsic differences in...
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Aromatization-driven intramolecular 1,5-hydride transfer reductive amination

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00632A, Research Article

Wenquan Wang, Yu He, Jinhui Yang
An aromatization-driven intramolecular 1,5-hydride transfer reductive amination for the synthesis of N-benzyl-2-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline derivatives has been established.
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Benzophenone-mediated deconstructive cross-coupling of secondary alcohols with data-driven mechanistic insights

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00813E, Research Article

Kodai Takayama, Naoki Noto, Susumu Saito, Takamitsu Hosoya, Yuto Sumida
We report a Ni-catalyzed deconstructive cross-coupling of secondary alcohols under photochemical conditions using a benzophenone-derived organic photocatalyst. The reaction provides access to alkyl radicals from electron-rich benzylic alcohols and enables...
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Copper-Catalyzed Remote η-Aminoalkylation of 4-Yne-Naphthalene Esters with Amines

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00672H, Research Article

Huanshi Wang, Guangyuan Shi, Jiaqi Pu, Shi-Wu Li
A copper-catalyzed asymmetric remote η-aminoalkylation of 4-yne-naphthalene esters with various amines is reported. This transformation represents the first example of amination of propargylic substrates spaced by a naphthalene ring. A...
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Difluorocarbene-enabled N-deuteroformylation of amines and sulfonamides: access to formamide-1-d and N-CH2D motifs

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00639F, Research Article

Sandeep Kumawat, Kallakuri Leela Manikya Naga Siva Jyothi, Venkata Narayana Kalevaru, Kotha Middela Rahul Reddy, Thota Munikrishna Teja, V. Pratap Reddy Gajulapalli, Sebastian Wohlrab, Kishore Natte
A straightforward protocol for the deuteroformylation of complex amines and sulfonamides using BrCF₂CO₂K and D₂O is described, providing versatile N-C(=O)D intermediates for the synthesis of N-CH₂D compounds.
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Metal-Free Photocatalytic Alkylation Using Alkylboronic Pinacol Esters

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00418K, Research Article

Dingyi Wang, Cong Wu, Lujing Niu
This study describes an environmentally friendly, visible-light-driven catalytic strategy that generates carbon radicals from alkyl boronates under metal-free conditions, thereby circumventing the cost and toxicity issues associated with traditional methods....
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Electrophile-Triggered Dearomatization of Indolylethylhydroxamic Acids for the Synthesis of Spiro[indole-3,2'-pyrrolidine] derivatives

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00626D, Research Article

Yeyao Yeyao Li, zhao fengyuan, Tianli Gao, Gao Yuting, Bo Han, Ruili Guo, Haojie Ma, Ji-Jiang Wang, Yuqi Zhang, Zhiqiang Ren
A dearomatization of indolylethylhydroxamic acids for the synthesis of spiro[indole-3,2'-pyrrolidine] derivatives have been developed for the first time. This method features mild reaction conditions, excellent yields, and high diastereoselectivity. Furthermore,...
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Metal-free regio- and chemoselective sulfonocyclization of tertiary enamides to access non-benzene-fused medium-sized rings via SO2 insertion

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00679E, Research Article

Ran Ding, Hao-Song Yu, Yi-Fei Zhu, Yin-Dong Wu, Lei Liu, Yu Guo, Zi-Rong Li, Hui Gao
Azocines, as privileged motifs, are essential to materials science and medicinal chemistry because of their unique 3D spatial properties.
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Tridentate PyMPAA ligands enable efficient Pd-catalyzed non-directed arene deuteration

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00600K, Research Article

Jiawei Han, Mengtao Zhu, Yu Meng, Tao Cen, Jian-Fei Bai, Jia Chen, Zhi-Jiang Jiang, Zhanghua Gao
We report a novel PyMPAA ligand for Pd-catalyzed non-directed hydrogen–deuterium exchange reactions, with successful application to various PAHs and drug molecules.
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Palladium direct arylation and annulation for the catalyzed regiocontrolled synthesis of quinolone derivatives

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00563B, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Bo Lan, Thierry Roisnel, Henri Doucet
Palladium-catalyzed one-pot quinolone synthesis with initial C–C bond formation via double C–H functionalization, followed by intramolecular C–N coupling.
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Advances in the synthesis of chiral benzo-fused N-heterocycles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00466K, Review Article

Muhammad Khuzaifa, Irsa Kainat, Qingle Zeng
This review provides a critical overview of modern asymmetric strategies for constructing chiral benzo-fused N-heterocycles, encompassing central-to-axial chirality control and sustainable catalysis, with an outlook on future challenges.
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Metal-free photocatalyzed difunctionalization of pyridines via oxazinopyridine intermediates

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00465B, Research Article

Yi Han Zhang, Minjie Jiang, Lufang Liao, Meng Chen, Fangrui Wu, Hong Qin, Zheng Fang
Researchers have developed an innovative synthetic strategy that enables difunctionalization of pyridines via oxazinopyridine intermediates, and further established a continuous-flow synthesis process for this reaction using microflow technology.
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Base-Mediated Double Defluorination and Bisthiolation of α-Trifluoromethyl Alkenes toward Monofluoroalkenes

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00557H, Research Article

Xin Guo, Hang Zhang, Long Xiao, Jiarui Liang, Guoliang Pu, Peng Guo, Jilin Wen, Jia Jia, Chun-Yang He
Monofluoroalkenes are valuable mimics of enol and amide bonds, making them pivotal in drug discovery. Here, we report a transition-metal-free defluorinative bisthioetherification of α-trifluoromethyl alkenes using thiols as the sulfur...
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Tandem catalytic Wittig reaction prepared isocoumarins: New family with tunable multi-stimuli-responsive fluorescence and bioactivity via halogen engineering

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00408C, Research Article

Mei Sun, Jie Zhou, Qiaoqiao Jia, Xiaogang Zhang, Wenya Song, Kai Chen, Cuie Shi, Jiaxin Hong, Chongyang Zeng, Mingwu Ding
To address the limitations of current stimuli-responsive fluorophores in precision medicine and elucidate the role of halogen atoms, a novel family of isocoumarins (ICP-X) featuring both multi-stimuli-responsiveness and bioactivity were...
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Nickel-catalyzed annulation of strained cyclic allene and benzodicarboxylic anhydride

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00720A, Research Article

Guo Yifeng, Zijun Zhou, Lei Cui, Peng Xu, Xinyao Li, Jian Li
Strained cyclic allenes represent a class of in situ-generated transient intermediates with considerable ring strain and high chemical reactivity. These species are advantageous building blocks for the synthesis of complex...
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Cobalt-Catalyzed Aerobic Intramolecular Hydroarylation of Allylic Alcohols via Hydrogen Atom Transfer and 1,2-Aryl Migration in HFIP

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00689B, Research Article

Xiao-Qing Xie, Chen-Jin Rao, Zi-Qiong Li, Chaozhihui Cheng, Lin Lu, Xian-Rong Song, Mu-Jia Luo, Qiang Xiao
Aryl migration represents a powerful strategy for the selective reconstruction of carbon-skeleton with high atom- and step-economy. Herein, an efficient cobalt-catalyzed 1,2-aryl migration for the intramolecular hydroarylation of allylic alcohols...
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Long Visible-Light-Driven Bilin-Based Rotary Molecular Systems: from batch to microfluidics techniques

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00273K, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lidia Hortigüela, Juan Antonio Garcia-Romero, Jose Justicia, Antonio J. Mota, Fátima Fernández-Álvarez, Ana M. Garcia, Araceli G. Campaña, Victor Blanco, Maria Victoria Gomez, Sara P. Morcillo
Expanding the library of visible-light-driven rotary molecular systems (RMSs) requires chromophores with defined photochemical reactivity and thermal robustness. Herein, we report the design, synthesis, characterization and computational study of a...
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A General Photocatalytic Strategy for Allylic C(sp3)–H Functionalization with Nucleophiles using Cyclohexyl Radical as a Hydrogen Atom Abstractor

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D5QO00991J, Research Article

Qinhui Qinhui Chen, Yigao Tao, Rong Hu
The selective transformation of hydrocarbons has become an exceedingly difficult challenge, especially in a stereo-selective manner. Despite remarkable progress, the simultaneous achievement of strong bond activation and versatile functionalization with...
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C-H functionalization reactions of heterocycles with alkyl halides via halogen atom transfer

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00654J, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sudip Senapati, Anindya Das, Lilia Weizel, Daniel Merk, Ewgenij Proschak, Sandip Murarka, Rene M Koenigs
Direct C-H alkylation of heterocycles is a fundamentally important strategy for the late-stage diversification of natural products and bioactive molecules, as it enables atom-and step-economic access to sp³-rich, three-dimensional scaffolds...
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Enantioselective Cyanation-Brook Rearrangement-Protonation of Acylsilanes and Stereospecific Inversion in Brook Rearrangements Generating α-Nitrile Carbanion Equivalents

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00669H, Research Article

Michiko Sasaki, Kei Takeda
The stereochemical course of Brook rearrangements that generate formal α-nitrile carbanion equivalents remains difficult to define because the resulting anionic species are intrinsically configurationally labile. Here we report two complementary...
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Photoelectrochemical hydroxymethylation and cyclization of N-aryl-2-CF3-acrylamides with TMSCH2OH

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00697C, Research Article

Lei Wang, Zhong-Wei Hou, Fei-Fei Xu, Quan Zhou
An organocatalyzed photoelectrochemical approach for the radical-mediated hydroxymethylation and cyclization of N-aryl-2-CF3-acrylamides with (trimethylsilyl)methanol (TMSCH2OH) has been developed. This reaction employs 2chloroanthraquinone (2-Cl-AQ) as the organocatalyst and TMSCH2OH as the...
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Unravelling the Assembly Pathways of Hydrogen-Bonded Amide-based [2]Rotaxanes: a Computational and Experimental Study

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00724D, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Daniel Hernandez-Hidalgo, Jose Manuel Garcia-Romera, Marta Marin-Luna, Alberto Martinez-Cuezva, Jose Berna
The assembly mechanism of hydrogen-bonded tetraamide-based [2]rotaxanes is studied through a combined computational and experimental approach. Two possible pathways, involving U-shaped and C-shaped intermediates, were investigated, revealing that U-shaped intermediates...
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Synthesis of α-quaternary amino acid derivative via 1,2-rearrangement of ammonium ylide

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00155F, Research Article

Ao Huang, Rui Li, Zhenxiu Huang, Lei Wang, Xin Wang, Kaixin Du, Shi Tang
Although α-quaternary amino acids often exhibit notable bioactivity, their synthesis has received comparatively less attention, primarily due to the considerable steric hindrance posed by the quaternary center.
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Synthesis of Rigid-Flexible Chiral Borinic Acids and Application in Desymmetrization of Diols

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00673F, Research Article

Shan-SHan Xun, Gao-Wei Wang, Muwang Chen, Yong-Gui Zhou, Sheng-Mei Lu
Despite recent progress achieved in the development and application of chiral organoboron acid catalysts, the efficient chiral catalysts remain scarce due to the inferior stereocontrol arising from planar geometry of...
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N-Heterocyclic Carbene Catalyzed Enantioselective [5+1] Annulation to Access Indole-fused Spirocycles: A Remote δ-Carbon activation

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00374E, Research Article

Zhihang Li, Xiaoyong Duan, Dongyan Li, Keqing Liang, Qianqian Yang, Chang Guo, Zitong Yao, Chunfang Zhang, Jing Qi
Herein, we report the NHC-catalyzed enantioselective [5+1] annulation between indole-derived α,β,γ,δ-unsaturated aldehydes and 3-aminomaleimides. This methodology provides an efficient approach for constructing enantiomerically enriched indole-based spirocycles in good to excellent...
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Tryptophan-Selective Multicomponent Annulation for Direct Construction of Peptide-Embedded 2H-Chromenes

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00633G, Research Article

Cheng Ren, Lumeng Sun, Yicheng Lv, Xingxing Yang, Lin Yang, Chengxi Li
Direct construction of heterocycles within peptide frameworks offers a concise strategy for expanding peptide chemical space, yet the development of chromene-forming annulation reactions compatible with peptides remains limited. Here we...
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Dearomative 1,6-Difunctionalization of Styrenes via Photoredox Palladium Catalysis

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00706F, Research Article

Xin-Han Wang, Xin-He Han, Chun-Lin Zhang, Song Ye
An efficient dearomative 1,6-difunctionalization of styrenes was developed via photoredox palladium catalysis, giving the corresponding alkylidenecyclohexadienes in moderate to good yields. Axially chiral alkylidenecyclohexadienes was obtained with promising enantioselectivity when...
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Enantioselective Diastereodivergent Reactions between Aldehydes and Bicyclo[1.1.0]butanes

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00662K, Research Article

Chengzhuo Wang, Shi Cheng, Zhidong Zhang, Liu Li, Ning Chen, Zhanhui Yang, Jiaxi Xu
Developing diastereodivergent and enantioselective catalytic reactions to access structurally and stereogenically diverse molecules from identical starting materials remains a central challenge in organic synthesis. Optically active three-dimensional saturated oxabicyclo[2.1.1]hexanes (oxaBCHs)...
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Switchable divergent reactions of α-aryl vinylsulfoniums with benzothiophene- and benzofuran-based aza-dienes

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00664G, Research Article

Jiao Yuan, Dong-Qun Huang, Lei Yang, Jian-Qiang Zhao, Yong You, Wei-Cheng Yuan, Zhen-Hua Wang
A switchable divergent reaction between α-aryl vinylsulfoniums and aza-dienes has been developed, enabling the one-pot synthesis of sulfur-containing 6–5–6- and 6–5–5-fused tricyclic compounds, as well as benzothiophene and benzofuran derivatives.
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Reductive coupling of aryl (pseudo)halides towards symmetrical biaryls via a dual Ni/photoredox catalysis

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00661B, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sadiq Strey, Kristin Olbricht, Daniel Sommer, Dino Berthold
We demonstrate that dual Ni/photoredox catalysis enables a general reductive approach to symmetrical biaryls using simple amines as mild reducing agents.
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A visible-light-induced, N-heterocyclic carbene-catalyzed four-component reaction of aroyl fluorides, diazo esters, cyclic ethers, and H2O

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00454G, Research Article

Jiayuan Shui, Yulong Niu, Hao Chen, Chuanying Li, Ze-Feng Xu, Lei Wang
Herein, we introduce a synergistic visible light and N-heterocyclic carbene (NHC) promoted four-component reaction of aroyl fluorides, diazo esters, cyclic ethers and H2O, providing an effective strategy for the construction...
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Visible-light-induced highly efficient catalysis of nitro reduction by Pd and FeCl₃

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00601A, Research Article

Tianshu Qin, Lirong Yao, Hao Wu, Yihong Wang, Yue Chen, Dong Liu, aiqin liu, Zhushuang Bai
Substituted aromatic amines or heteroaromatic amines constitute a significant class of chemical intermediates. This paper reports a synergistic catalytic system comprising Pd/C and FeCl₃, which reduces nitro groups to amino...
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Iron-Catalyzed Photoinduced Monohalogenation of α-Diazo Esters Using Halide Salt as Halogen Source

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00435K, Research Article

Pengjie Yao, Jingwen Yang, Yi Ma, Long Sun, Hongyan Zhao, Kangkui Li, Jingchao Chen, Baomin Fan
Halogenated compounds are valuable intermediates in organic synthesis, yet selective monohalogenation, especially chlorination, remains challenging under mild conditions. Herein, we report an iron-catalyzed, visible-light-induced ligand-to-metal charge transfer monochlorination and monobromination...
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Continuous-flow functionalization of furfural: synthetic strategies for furan-containing value-added chemicals

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00542J, Review Article

Serik Zhumagazy, Nursaya Zhumabay, Nurxat Nuraje
This review summarizes continuous-flow methods for efficient furfural diversification. It highlights advanced post-modification strategies to access furan-containing high-value chemicals with better safety, selectivity, and scalability.
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One-pot access to quinoline–chalcone hybrids via the iron-catalyzed aerobic oxidative sp3 C–H activation of unactivated alkylquinolines

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00583G, Research Article

Sangmyung Han, Seok Beom Lee, Jinwoo Lee, Hyungwoo Choi, Joonseok Jang, Suckchang Hong
One-pot strategy for the direct synthesis of quinoline–chalcone hybrids from unactivated 4-alkylquinolines is developed via sequential iron-catalyzed aerobic oxidative sp³ C–H activation and aldol condensation.
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Accessing diverse N-centered peri fused cycles (NCPCs): Rh(III) catalyzed generation of triazaacenaphthylenes through C-5(H) activation of imidazo[1,2-a]pyridine

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00416D, Research Article

Mehak Sood, Kousar Jahan, Satheesh Nijalingappa, Subash C. Sahoo, Prasad V. Bharatam
N-centered peri fused cycles (NCPCs) : Synthesis of Triazaacenaphthylene via C-5(H) activation of imidazo[1,2-a]pyridine.
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Biocompatible indole C2 functionalization via transient N-acyliminium borate intermediates

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00458J, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Huitao Liu, Yaojie Li, Peng Chen, Lei Wang, Lijuan Liang, Teck-Peng Loh, Zhenhua Jia
A metal-free, biocompatible method for indole C2 functionalization is reported, proceeding via ion-pair catalysis that involves the in situ generation of transient N-acyliminium–borate intermediates.
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Photocatalytic asymmetric cross-couplings via a radical Brook rearrangement

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00624H, Research Article

Danhua Qian, Songwei Wen
Nickel/photoredox-catalyzed asymmetric Hiyama-type cross-couplings via radical Brook rearrangement.
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Sulfinate-assisted, photoredox-catalyzed insertion of alkenes into the C–N bond of acyl azoles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00433D, Research Article

Jing-Mei Yuan, Kai Zhang, Jia-Hui Li, Lin Qin, Cheng-Li Wei, Qin-Ning Ye, Jing Yang, Jun Huang
A selective insertion of alkenes into the C–N bond of acyl azoles by sulfinate assisted photoredox catalysis is established.
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Stereoselective construction of cyclic quaternary stereocenters by Prins cyclization with ketones

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00617E, Research Article

Laura F. Peña, Lucía G. Parte, Carlos Díez-Poza, Asunción Barbero
A general Prins-type cyclization with ketone substrates that enables the efficient and stereoselective construction of tetrahydropyrans bearing quaternary carbon centers is described.
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Enantioselective synthesis of fluorine-containing spiro[indanone-isochromanone] derivatives with contiguous quaternary carbon centers via organocatalytic asymmetric [4 + 2] condensations

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00395H, Research Article

Qian Li, Fang-Lin Chen, Cheng-Bin Deng, Yonghui He, Ganpeng Li, Xiao-Jing Zhao
Herein, we report the synthesis of fluorine-containing spiro[indanone-isochromanone] derivatives with contiguous quaternary carbon centers via catalytic asymmetric [2 + 4] cyclizations using axially chiral styrene-based organocatalysts.
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Halogen-regulated intramolecular through-space conjugated emission and room temperature phosphorescence of halogenated cyclooctatetrathiophene

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00593D, Research Article

Zhixia Zhang, Sheng Zhang, Wan Xu, Li Xu, Shuai Qiu, Hua Wang
A series of novel saddle-shaped halogenated cyclooctatetrathiophenes (COTh-mXs, m = 1, 2, 3, 4; X = F, Cl, Br, I) was successfully synthesized. These COTh-mXs exhibited notable ITSC and RTP.
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Iron-catalyzed arene C–H cyanation suitable for complex molecules

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00594B, Research Article

Ran Liu, Ru Wang, Ning Xu, Qian Chen, Bowen Cao, Wentao Ji, Wei-Jin Gu, Kangkang Sun, Wei Han
Amino acid-ligated iron catalysis enables non-directed oxidative C–H cyanation of (hetero)arenes and late-stage functionalization of complex bioactive molecules.
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Construction of Fluorinated Tertiary Allylamines via Three-component Photocatalytic Defluorinative Aminoalkylation of gem-Difluoroalkenes

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00767H, Research Article

Ji Luo, Kexu Zhu, Xiaodong Fang, Yong Jian, Daohai Zhang, Zhongli Wu, Hongqing Li, Binbin Huang, Junlei Wang
The incorporation of fluorinated tertiary allylamine motifs into bioactive compounds holds significant importance owing to their notable physiological properties. Herein, we report a concise defluorinative aminoalkylation protocol facilitated by a...
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Solvent-controlled regioselective iodocyclization of propargylic amides

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00517A, Research Article

Huilin Zhan, Run Yu, Shuxuan Liu, Zhengyu Han, Hai Huang
In this study, a solvent-controlled electrophilic iodocyclization reaction of propargylic amides has been developed, enabling the highly regioselective synthesis of oxazolidine-2,4-dione and 1,3-oxazine-2,4-dione compounds.
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Thioxanthone-modified flavin for photo-decarboxylation of aromatic acids to enable C-2 arylation of nitrogen heterocycles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00493H, Research Article

Yuying Gu, Hao Wang, Yao Zhao, Yu Zhang, Houhai Fan, Xiliang Xu, Weiwei Zhang, Xianbo Du, Wenyi Chu
This decarboxylation arylation scheme overcomes the stability problem of flavin under high-energy light and obtains a series of 2-aryl nitrogen-containing heterocyclic compounds with moderate to good yields.
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Cycloaddition/ring-opening cascade reaction of alkylidene azlactones for the synthesis of α,α-disubstituted α-amino acid esters

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00556J, Research Article

Jyoti Sikarwar, Jyoti Chauhan, Rama Krishna Peddinti
Solvent-controlled, metal-free diastereoselective cascade reaction between alkylidene azlactones and N-phenacylbenzothiazolium salts enabling efficient access to pyrrolo[2,1-b]benzothiazole-based α,α-disubstituted α-amino acid esters is reported.
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Theoretical insights into the mechanism and ligand-controlled chemoselectivity of multicomponent carbonylation toward γ-butenolide and ynone

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00634E, Research Article

Guanghui Song, Wen Zeng, Yanting Lan, Xuande Su, Juan Li
DFT calculations were employed to explore the detailed reaction mechanism, the role of CuI and the origins of the regio-, and chemoselectivities in ligand-controlled multicomponent carbonylation reactions.
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Supramolecular modulation of π-extended pyridinium photosensitizers for enhanced dual reactive oxygen species photocatalysis

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00592F, Research Article

Yu-Song Bi, Man Jiang, Wen-Qiang Liu, Ling-Bao Xing
Supramolecular assembly of a phenyl-substituted pyridinium photosensitizer with cucurbit[n]uril enhances dual ROS generation (¹O₂ and O2˙⁻), enabling efficient metal-free cross-dehydrogenative coupling in water for sustainable synthesis.
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Remote asymmetric amination of naphthalene-blocked alkynes with various amines

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00609D, Research Article

Su Xie, Shi-Wu Li
In this study, we rationally designed and successfully established a versatile copper-catalyzed divergent reaction system by employing alkynyl naphthalates as key substrates.
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Highly selective (deuterated) defluorinative hydrogenation of trifluoroacetamides

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00467A, Research Article

Ruiqi Guo, Yue Chen, Yong Li, Feng Gao, Aiqin Liu, Jingxiang Pang, Zhushuang Bai
The (deuterium-labeled) difluoromethyl (–CF₂H) and monofluoromethyl (–CFH₂) groups play important roles in numerous pharmaceuticals and pesticides due to their unique properties.
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Transition-metal-free synthesis of bipyridines from pyridyl pyrimidylsulfones

Org. Chem. Front., 2026, 13,3774-3779
DOI: 10.1039/D6QO00332J, Research Article

Hayoung Kim, Young-hwa Jin, Seonghun Kim, Jeong-Hun Sohn
Transition-metal-free cross-coupling of pyridyl pyrimidylsulfones with azaaryl Grignard reagents enables direct access to 2,2′-, 2,3′-, and 2,4′-bipyridines, and related bis-azaaryl products under mild conditions.
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Stereospecific SuFEx reactivity of highly enantioenriched sulfondiimidoyl fluorides

Org. Chem. Front., 2026, 13,3735-3743
DOI: 10.1039/D6QO00230G, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Glebs Jersovs, Aldis J. Pivars, Julija Bariseva, Vadims Kovada, Pavel A. Donets, Edgars Suna
Stereospecific SuFEx reactivity of highly enantioenriched sulfondiimidoyl fluorides enables direct access to sulfone diimines, sulfondiimidamides and sulfondiimidates with complete chirality transfer.
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A furan prism cage: synthesis, guest recognition, and applications in constructing charge-transfer co-crystals

Org. Chem. Front., 2026, 13,3754-3762
DOI: 10.1039/D6QO00344C, Research Article

Yongwei Qian, Shengyang Huang, Shengwen Li, Zhenzhuo Liu, Guangcheng Wu, Yingchun Liu, Jiyong Liu, Bin Sun, Ming Li, Hao Li
Electron-rich supramolecular hosts with well-defined cavities are attractive for functional applications, but the construction of three-dimensional organic cages often relies on complex irreversible reactions.
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Re(I)-catalyzed C–C and C–S bond formation via regioselective C(sp2)–H hydroalkylation and hydrothiolation

Org. Chem. Front., 2026, 13,3780-3785
DOI: 10.1039/D6QO00268D, Research Article

Khushboo Tiwari, Suman Bhowmick, Mayank Singh, Rajani Kant, Dharmendra Kumar Tiwari
A Re(I)-catalysed dual hydroalkylation method enables Markovnikov-selective O–C(sp²)–H functionalisation of phenols and anti-Markovnikov hydroalkylation of thiophenols. Biologically important phenols also undergo efficient ortho-functionalisation.
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A co-registered molecular keypad lock for the generation of singlet oxygen

Org. Chem. Front., 2026, 13,3637-3645
DOI: 10.1039/D6QO00295A, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jialei Chen-Wu, José A. González-Delgado, Uwe Pischel
A dithienylethene-anthracene dyad enables the photocontrolled switching of ¹O₂ formation and functions as an all-photonic molecular keypad lock.
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Visible-light-induced diastereoselective synthesis of β-lactams via a Cu(I)-catalyzed cascade 1,5-H shift/cyclization

Org. Chem. Front., 2026, 13,3619-3627
DOI: 10.1039/D6QO00281A, Research Article

Ke Zhang, Sinuo Li, Hengrui Zhou, Fang Zhang, Linna Guo, Yunqiang Li, Zhiwei Jiao
A visible-light-driven copper(I)-catalyzed 1,5-HAT/cyclization enables efficient synthesis of β-lactams with good to excellent diastereoselectivity.
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Cascade reaction of 2-halo-4-alkenyloxazoles with arynes: a switchable divergent synthesis of 2-arylnaphtho[2,1-d]oxazoles, N-acylnaphthylamines, and α-halonaphthalenes

Org. Chem. Front., 2026, 13,3609-3618
DOI: 10.1039/D6QO00276E, Research Article

Yingyi Wang, Yaoyao Mei, Guilin Li, Feng Sha, Xinyan Wu
A novel cascade reaction of 2-halo-4-alkenyloxazoles with arynes affords switchable divergent synthesis of 2-arylnaphtho[2,1-d]oxazoles, N-acylnaphthylamines, and α-halonaphthalenes, with high selectivity by tuning reaction conditions.
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Rotating magnetic field-enhanced PPh3-mediated deoxygenative C–N coupling of nitroarenes with boronic acids

Org. Chem. Front., 2026, 13,3674-3682
DOI: 10.1039/D6QO00188B, Research Article

Yanan Zhang, Aojie Zhang, Yue Zhang, Qing Liu, Fachao Yan, Qiang Liu, Lizhi Zhang, Maojin Tian, Zengdian Zhao, Hui Liu
Herein, we report a solvent-free electromagnetic mechanochemical protocol for PPh₃-promoted deoxygenative C–N coupling of nitroarenes with boronic acids under a rotating magnetic field, featuring excellent halogen tolerance.
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Self-aggregation and host–guest behavior of tetraureido-substituted tetranitro-azacalix[4]arenes

Org. Chem. Front., 2026, 13,3683-3696
DOI: 10.1039/D6QO00354K, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Karolína Salvadori, Sabrina Pricl, Aura Tintaru, Alena Krupková, Václav Eigner, Pavel Matějka, Pavel Lhoták, Olivier Siri
Tetraureido tetranitro-azacalix[4]arene architectures are substitution-tunable supramolecular systems representing promising anion receptors, with potential to form self-assemblies, both modulated by the nature of the aryl substituents.
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Recent developments in carbonyl–olefin metathesis

Org. Chem. Front., 2026, 13,3846-3873
DOI: 10.1039/D5QO01435B, Review Article

Lekkala Ravindar, Lekkala Revathi, Yee Ling Lau
Due to its exceptional atom-economy and efficiency, the construction of C–C bonds via metathesis reactions between carbonyls and olefins has drawn significant attention in organic chemistry.
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Photoinduced deconstruction of cycloalkanols for site-selective sulfonylsulfination

Org. Chem. Front., 2026, 13,3728-3734
DOI: 10.1039/D6QO00206D, Research Article

Wen-Chao Gao, Yong Teng, Zi-Han Li, He-Yun Sheng, Wen-Guang Li, Yong-Qi Yu, Meng-Meng Liu, Ting Li
A photo-enabled deconstructive sulfonylsulfination of cycloalkanols affording synthetically useful ketones bearing a β-sulfonyl sultine moiety with S^IV and S^VI centers has been successfully developed.
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Spin-selective generation of triplet alkenylcarbenes: olefin cyclopropanation through visible light photosensitization of alkenyldiazo compounds

Org. Chem. Front., 2026, 13,3786-3793
DOI: 10.1039/D6QO00337K, Research Article

Sen Li, Shilin He, Yangzheng Lin, Jinbao Han, Jiating Li, Shaohui Lin, Lei Shi, Zhen Guo
Visible-light-induced energy transfer from 4DPAIPN enables spin-selective generation of triplet alkenylcarbenes from alkenyldiazo compounds, providing a metal-free cyclopropanation route to alkenylcyclopropanes with broad functional group tolerance.
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Palladium-catalyzed aminative cross-coupling of aryl thianthrenium salts with arylboronic acids and DPPH

Org. Chem. Front., 2026, 13,3709-3716
DOI: 10.1039/D6QO00422A, Research Article

Jia-Ying Zhu, Kai-Qun Wu, Han Yu, Xue-Qiang Chu, Bing-Zhi Chen, Yucai Tang, Hao Xu, Zhi-Liang Shen
Palladium-catalyzed aminative cross-coupling of arylboronic acids and DPPH with readily available and versatile aryl thianthrenium salts proceeded smoothly via C–S bond cleavage to produce a wide range of diarylamines in moderate to good yields.
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Synthesis of 8-membered tetrahydroazocines via manganese-mediated regioselective sulfonylation/cyclization of N-substituted enamides with sodium sulfinites

Org. Chem. Front., 2026, 13,3697-3702
DOI: 10.1039/D6QO00401F, Research Article

Ran Ding, Chuan-Hao Zhang, Jia-Qi Yuan, Pei-Li Li, Xiao-Qing Yu, Zi-Rong Li, Hui Gao
Intermolecular radical cascade cyclization of tethered alkynes involving the cracking of aryl or vinyl C(sp²)–H has become an important pathway for the synthesis of benzene-fused or CC bond-containing heterocyclic building blocks.
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Site-selective α-C(sp3)–H bond functionalization of amines/amides via 1,2-hydrogen atom transfer

Org. Chem. Front., 2026, 13,3802-3824
DOI: 10.1039/D6QO00382F, Review Article

Dong Zou, Jiaqi Yao
Nitrogen-centered radical-mediated 1,2-hydrogen atom transfer (1,2-HAT) serves as a robust strategy for the site-selective α-C(sp³)–H functionalization of amines and amides.
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Thioacid-catalyzed selective photochemical oxidation reactions under mild conditions

Org. Chem. Front., 2026, 13,3744-3753
DOI: 10.1039/D6QO00271D, Research Article

Wenjing Li, Chunye Liu, Juan Tang, Siyu Shen, Lingling Liang, Lingzhi Zhao, Shun Li
Commercially available and versatile thioacids have been employed as catalysts for three representative selective photo-oxidation reactions, efficiently converting benzylic sp³ C–H bonds to ketones, alcohols and amines to aldehydes.
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Cu(II)-catalyzed [3 + 2] cycloaddition of enaminones and N-tosylaziridines leading to2,3-dihydropyrroles

Org. Chem. Front., 2026, 13,3668-3673
DOI: 10.1039/D6QO00319B, Research Article

Xu Zhang, Shiru Zhao, Guo Lv, Mengxin Chen, Wenguang Li, Xuefeng Xu
A copper-catalyzed [3 + 2] cycloaddition reaction between N-tosylaziridines and enaminones has been developed for the synthesis of functionalized 2,3-dihydropyrroles under ambient conditions.
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π-Extended dipyrrolopyrazines as multifunctional materials

Org. Chem. Front., 2026, 13,3717-3727
DOI: 10.1039/D6QO00350H, Research Article

Justin Kahle, Niklas J. Hermann, Martin C. Dietl, Patrick D. Römgens, Kim J. Warth, Christopher Hüßler, Alexandra V. Mackenroth, Fabian Baier, Ute Zschieschang, Petra Krämer, Frank Rominger, Matthias Rudolph, Hagen Klauk, Jana Zaumseil, A. Stephen K. Hashmi
π-Extended dipyrrolopyrazines were synthesized via gold catalysis. Besides strong luminescence, these compounds exhibit interesting thin-film-properties.
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Palladium-catalyzed domino sequence of ortho-X-allenyl tethered aryl isocyanides: access to fused benzazole frameworks

Org. Chem. Front., 2026, 13,3653-3659
DOI: 10.1039/D6QO00197A, Research Article

Leyla Saeifard, Kamran Amiri, Hormoz Khosravi, Felix Bauer, Frank Rominger, Bernhard Breit, Thomas J. J. Müller, Saeed Balalaie
A palladium-catalyzed domino sequence of a newly designed class of ortho-X-allenyl tethered aryl isocyanides has been developed. This one-pot process provides access to a wide array of 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles.
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Sacrifice of diorganyl diselenide enables cyclization of aryl propargyl ethers in the synthesis of 3-organoselenyl chromenones

Org. Chem. Front., 2026, 13,3660-3667
DOI: 10.1039/D6QO00274A, Research Article

Pedro Pauletto, Yago Cezar Bastianello, Davi F. Back, Cristina Wayne Nogueira, Gilson Zeni
We report the synthesis of 3-organoselenyl chromenones via a cascade cyclization of organoselenyl arylpropargyl ethers promoted by diorganyl diselenides and hydrogen peroxide.
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A photoswitchable macrocyclic ion-pair receptor

Org. Chem. Front., 2026, 13,3628-3636
DOI: 10.1039/D6QO00250A, Research Article

Kuirong Fu, Hui Liu, Xinyan Mai, Zhiyao Yang, Muyun Tao, Song Qin, Yimin Cai, Xiaowei Li, Wen Feng, Lihua Yuan
An azobenzene-based macrocyclic ion-pair receptor enables selective solid–liquid extraction of LiCl from mixed alkali chlorides. Reversible E–Z photoisomerization allows light-controlled capture and release of LiCl and receptor recycling.
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Post-Ugi synthesis of furo[2,3-c]isoquinolines with expanded π-conjugation displaying emission upon induced aggregation

Org. Chem. Front., 2026, 13,3763-3773
DOI: 10.1039/D6QO00311G, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tullio Crovetto, Lukas Biesen, Andrea Messina, Lisa Moni, Chiara Lambruschini, Bernhard Mayer, Thomas J. J. Müller, Renata Riva
Furo[2,3-c]isoquinolines are obtained by coupling the Ugi reaction with a complex Pd-mediated secondary transformation, followed by a β-elimination. Depending on the structure, they display aggregation induced or enhanced induced aggregation.
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Design of 365 nm light-triggered fluorogenic crosslinking via a genetically encoded 3-CF3-p-phenylenediamine-lysine featuring red-shifted photo-defluorination

Org. Chem. Front., 2026, 13,3646-3652
DOI: 10.1039/D6QO00284F, Research Article

Fan Zhang, Ziming Xiong, Siyu Kuang, Sitong Li, Xiaohu Zhao, Zhipeng Yu
3-CF₃-PDAK, a 2^nd-gen GCE-encoded photo-crosslinking ncAA, outperforms m-TFMAK via 365 nm light, showing a longer AcF half-life and fluorogenicity. When encoded in E. coli/mammalian cells, it enables visualization of PPIs via a photo-DAFEx reaction.
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Neocucurins A and B, two novel rearranged diterpenes from marine-derived fungus Neocucurbitaria unguis-hominis

Org. Chem. Front., 2026, 13,3703-3708
DOI: 10.1039/D6QO00264A, Research Article

Hongxin Liu, Jinhua Hu, Yuchan Chen, Shanshan Wei, Haibo Tan, Weimin Zhang
Neocucurin A is a diterpene with a unique 5/6/6/9 tetracyclic system, while neocucurin B features the characteristic bicyclo[8.3.1]tetradeca core skeleton, which is rearranged from the phomactin diterpene.
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A metal- and solvent-free bromination of electron-deficient allyl and benzyl C–H bonds

Org. Chem. Front., 2026, 13,3596-3601
DOI: 10.1039/D6QO00245E, Research Article

Quanjin Rong, Qianhe Wang, Fan Wang, Zhong-Quan Liu, Xiaojing Liu
Bromination reactions of C(sp³)–H bonds at allylic and benzylic positions have been widely applied in the synthesis of pharmaceuticals and functional materials.
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Visible-light-induced acylation of active olefins by a C–C bond cleavage/Smiles rearrangement radical relay strategy via EDA complexes

Org. Chem. Front., 2026, 13,3602-3608
DOI: 10.1039/D6QO00222F, Research Article

Long-Jin Zhong, Shun-Dan Li, Xiao-Han Ma, Peng-Fei Huang, Quan Zhou, Ke-Wen Tang, Chang-Hui Liu, Yu Liu
The first visible-light-induced EDA-complex-promoted acylation of 1,8-enynes through a C–C bond cleavage/Smiles rearrangement radical relay strategy is presented.
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α-Borylcarbene precursors: design, generation, and synthetic opportunities

Org. Chem. Front., 2026, 13,3825-3845
DOI: 10.1039/D6QO00368K, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Ryuya Miyazaki, Kei Muto, Junichiro Yamaguchi
α-Boryl carbene precursors have evolved from classical diazo compounds to modern platforms including alkynes and haloalkanes. This review highlights diverse carbene-generation and design which control reactivity and expand synthetic opportunities.
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A 4-nitro-3-arylpyrrole platform for the divergent synthesis of marine natural products: Ningalins and Lamellarins

Org. Chem. Front., 2026, 13,3589-3595
DOI: 10.1039/D6QO00105J, Research Article

Yihuan Yang, Guishun Bai, Jiajia Han, Mengyuan Wu, Yi Hua, Jianwei Chen, Jean Rodriguez, Damien Bonne, Hong Wang, Xiaoze Bao
3-Arylpyrrole platform was constructed in high efficiency via a Barton–Zard reaction for the gram-scale synthesis of Ningalin B and Lamellarin L.
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Capturing CO: palladium-catalyzed, BrCF2COOK-mediated one-pot carbonylative coupling for the synthesis of oxindoles

Org. Chem. Front., 2026, 13,3794-3801
DOI: 10.1039/D6QO00177G, Research Article

Shivam A. Meena, Deepika Thakur, Manvi Sharma, Akhilesh K. Verma
We herein report a Pd-catalyzed difluorocarbene transfer reaction that enables the efficient synthesis of carbonylative oxindole derivatives in good to excellent yields. In this transformation, commercially available BrCF₂COOK functions as practical difluorocarbene precursor and a safe, user-friendly carbonyl source.
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Enabling C–C bond-forming strategies for tailored derivatisation of heptazine frameworks

Org. Chem. Front., 2026, 13,3580-3588
DOI: 10.1039/D6QO00267F, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Aurélien Huet, Benjamin Louis, Rana Deeba, Ahmed Ait Khouya, Yves Chenavier, Renaud Demadrille, Jacques Pécaut, Lionel Dubois, Julie Andrez
Herein we report previously inaccessible functionalisation by C–C coupling reactions enabling the derivatisation of a broader range of heptazines in many different research fields.
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One-pot synthesis of pyrimido[1,2-a]benzimidazoles using calcium carbide as an acetylene source

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00446F, Research Article

Cuimei Liu, Rui An, Peiming Gu, Meng-Xue Wei
A highly pot-, atom-, and step-economical strategy for the synthesis of pyrimido[1,2-a]benzimidazoles exhibiting strong yellow photoluminescence.
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Chemo- and stereoselective Rh(III)-catalyzed coupling of indoles with CF3-imidoyl sulfoxonium ylides via thioamide-directed C–H activation

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00532B, Research Article

Hongliang Wu, Ruirui Zhai, Liming Zhou, Siyu Chang, Guiwei Yao, Chen Li, Fengjuan Chen, Dulin Kong, Xun Chen
A thioamide-directed, Rh(III)-catalyzed divergent coupling of indoles with CF₃-imidoyl sulfoxonium ylides is developed.
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Physical organic origin of ligand-controlled β/γ-regiodivergence in NiH-catalyzed hydroalkylation

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00581K, Research Article

Simeng Qi, Ran Fang, Lizi Yang
Ligand-controlled NiH hydroalkylation: β/γ regiodivergence arises from competition between chain walking and radical rebound. DFT shows ligand-dependent spin-state access and β-H elimination govern selectivity, enabling descriptor-guided design.
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Redox-neutral electrochemical diazo coupling: controlled synthesis of olefins and azines via modulating reaction conditions

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00499G, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Abinash Mohapatra, Vikas Tyagi
We report a metal-free, linear paired redox-neutral electrochemical diazo coupling that enables the controllable synthesis of olefins and azines by modulating reaction conditions.
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Deaminative trifluoromethylation of alkyl amines enabled by photoexcited copper complexes

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00659K, Research Article

Xian Gong, Hu Du, Yingying Li, Weihang Miao, Shengqing Zhu, Lingling Chu
A photoexcited copper complex-enabled strategy is reported for deaminative trifluoromethylation of alkyl amines via crude isonitriles under mild conditions.
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Radical cyclization via selective C–X bond transformation

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00445H, Review Article

Hong-Lin Wu, Jie-Xi Guo, Cuiyan Wu, Ya-Ge Zheng, Jun-Qi Liu, Shi-Qing Zhang, Jia-Wei Wu, Wei Yang, Wen-Ting Wei
This review systematically summarizes recent advances in four radical activation pathways for carbon-halogen bonds: Direct C–X bond homolysis, PET, SET, and XAT, covering their reaction mechanisms, catalytic systems, and substrate scopes.
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Manganese(I)–CNP complex-catalyzed multicomponent synthesis of 2-pyrazolines by acceptorless alcohol dehydrogenation

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00513F, Research Article

Xiaohui Zhu, Jiangui Zhao, Hua Chen, Xueli Zheng, Haiyan Fu, Weichao Xue, Ruixiang Li
This study disclosed an efficient multicomponent cascade reaction for the synthesis of structurally diverse 2-pyrazolines through inexpensive first-row manganese(I) complex-mediated acceptorless alcohol dehydrogenation.
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One stone, two birds: diverse glycopeptide synthesis via radical Ullmann coupling from serine

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00586A, Research Article

Shuang Wang, Qiuju Zhong, Xinru Liang, Gaoqiang Li, Mingyu Yang
Herein, we reports a two-in-one strategy to streamline glycopeptide synthesis by sequentially modifying identical peptide precursors.
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Pd-catalyzed stereoselective enol ether coupling toward C2-branched carbohydrates: experimental and computational insights into glycal-controlled diastereoselectivity

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00511J, Research Article

Ram P. Pandey, Bindu Tiwari, Mursaleem Ansari, Nazar Hussain
A ligand-free Pd-catalyzed coupling of cyclic enol ethers, enabling C2-branched sugars with excellent diastereoselectivity. Computations identify the axial C4 substituent as the key stereocontrolling element via interaction-controlled insertion.
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Three-component synthesis of β-phostams

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00590J, Research Article

Wenlong Tong, Chengzhuo Wang, Mengyao Zhang, Jiaxi Xu
Various β-phosphinolactams (β-phostams) are directly synthesized from readily available diarylmethylphosphonochloridates, cinnamaldehydes, and lithium hexamethyldisilylamide via the [2 + 2] annulation of imines and phosphenes.
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Transition metal-catalyzed monodentate directing group-assisted C–H functionalization: an overview of advances (2015–2024)

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00602G, Review Article

Lei Wang, Fei Yao, Pu-Fan Qian, Xin-Shang Hui, Bing-Jie Wang, Jun-Yi Li, Ming-Ya Teng, Tian-Yu Jiang, Ke-Xin Kong, Chen-Yue Wang, Zi-Jia Chen, Yao-Le Jiang, Yan-Xuan Wu, Ao-Lian Jiang, Boyang Jiang, Yi-Jie Gao, Liu De-Yang, Jia-Heng Hu, Qi-Jun Yao, Tao Zhou, Bing-Feng Shi
Transition-metal-catalyzed directed C–H activation provides an efficient and atom-economical platform for forging carbon–carbon and carbon–heteroatom bonds. Among the diverse strategies, methodologies employing monodentate directing groups (MDGs) have emerged as particularly...
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Twofold 4-to-6 ring expansion of azetines to bis-halogenated pyridines

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00502K, Research Article

Rahma Ghazali, Elias Schick, Stefan Immel, Dorian Didier
A sequence of two consecutive skeletal editing steps through carbon insertions has been developed and allows the regioselective ring expansion of functionalized 2H-azetines to 3,5-bis-halogenated pyridines.
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Manganese-catalyzed chemodivergent transfer hydrogenation of unsaturated esters switched by solvent

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00533K, Research Article

Yin Guo, Lixian Wang, Xinyu Ge, Zaoliang Meng, Fang Wang, Yanqun Wang, Wei Sun, Qiangsheng Sun
Chemodivergent transfer hydrogenation of unsaturated esters is achieved using a manganese complex with ammonia borane. CC reduction furnishes saturated esters in dioxane, whereas full reduction delivers primary alcohols in MTBE.
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Unlocking XAT/HAT selectivity: a machine learning-guided discovery of governing physicochemical principles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00596A, Research Article

Siqi Liu, Wenqiang Xu, Tian-Yu Sun, Longjie Huang, Yun-Dong Wu, Xinhao Zhang
Machine learning couples with DFT calculations to unlock the governing principles of HAT/XAT selectivity, establishing a robust predictive platform for physical organic chemistry.
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High-throughput hydrogen isotope exchange via transfer deuteration

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00301J, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Anika Schick, Christoph Bauer, Tove Slagbrand, Michael Guerzoni, Maria Johansson, Sahil Gahlawat, Magnus Johansson, Per-Ola Norrby, Charles S. Elmore, Markus Artelsmair
We developed a rapid screening protocol based on transfer deuteration using formic acid-d₂ as the deuterium source. These conditions allow rapid screening of up to 96 hydrogen-isotope-exchange reactions in a controlled and safe manner.
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Enantioselective copper-catalyzed synthesis of axially chiral deuterated biaryl ethers and phenols from cyclic iodonium salts

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00531D, Research Article

Wei-Yuan Ma, Maorui Zhu, Zenghui Ye, Xi Zhang, Jian-Xing Xu, Fengzhi Zhang
We report a facile and mild method for the synthesis of axially chiral deuterated diaryl methyl ethers, ethyl ethers and phenols from cyclic iodonium salts.
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Thianthrenation-enabled metal-free heterodifunctionalization of unactivated alkenes with thiols and readily available N/O nucleophiles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00627B, Research Article

Lude Wang, Mengfan Wang, Jing Xiao, Xiumin Ge, Shunyu Tu, Chunya Li, Dong-Hui Lan, Shuang-Feng Yin
The metal-free 1,2-sulfenylamination, 1,2-acyloxysulfenylation, and 1,2-hydroxysulfenylation of alkenes were achieved via thianthrenation using thiophenols, amines, carboxylic acids, and water as nucleophiles.
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Visible-light-induced and diastereoselective synthesis of fluorinated tetrahydrofuran derivatives

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00585C, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xiangyu Tan, Carolina Gimbert-Suriñach, Elies Molins, Roser Pleixats, Israel Fernández, Adelina Vallribera, Albert Granados
Herein, we describe the stereocontrolled photoinduced construction of three contiguous stereocenters using trifluoromethylthianthrenium triflate and different nucleophiles.
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Photoredox-catalyzed oxygen-centered radical-mediated α-alkoxycarbonyloxylation of ketones

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00472E, Research Article

Yali Yan, Jianlin Hu, Houxiong Zhang, Zhengshan Yang, Jinyu Yang, Han Xu, Yanju Long, Xuan Zhang, Wenbin Shang
Herein, we report a visible-light photoredox-catalyzed α-alkoxycarbonyloxylation of ketones using pyridinium-derived alkoxycarbonyloxyl radicals (ACORs).
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