RSC - Org. Chem. Front. latest articles

Electronic Modification of Hexa-2,4-diyne-1,6-diols: Predictive Access to Strained Cyclobutenes and 3(2H)-Furanones

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00056H, Research Article

Seyed Mohammad-Bagher-Hosseini Ghazvini, Diego Cordova, Ingrid Dell, Elena Dallerba, Carol Hua, Paul Low, Massimiliano Massi, Marcus Korb
The acid-mediated activation of hexa-2,4-diyne-1,6-diols (1) is the standard protocol for the formation of valuable strained 1,2-dihalocyclobutenes/1,2-dihalobutafulvenes (3). However, the reaction is sluggish, associated with poor yields caused by formation...
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β- and Z-selective metal-free cyanation of ynamides: a direct approach to piperidines fused to arenes

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00022C, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Dorian Schutz, Wenwen Yang, Laurence Miesch
Stereodefined β-cyanoenamides were synthesized from ynamides using TMSCN/TBAF. Strategic nitrile activation with TMSOTf promoted intramolecular cyclization, delivering densely functionalized piperidines in a streamlined sequence.
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Divergent transformations of N-phenyl-N-tosylfluoroacetamides to amides and imides (N-tosylamides)

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00069J, Research Article

Nan Wang, Xia Chen, Chun-Yan Liu, Zhi-Ying Feng, Ming Bao, Xiao-Yu Zhou
Two efficient and convenient approaches were developed for selective C–N coupling by utilizing divergent fragments of N-phenyl-N-tosylfluoroacetamides.
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Unveiling the mechanisms of gold/copper bimetallic catalysis in the synthesis of complex heterocyclic compounds

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D5QO01639H, Research Article

Fengjuan Ma, Qing Sun, Jingxin Hu, Xin Cheng, Huiwen Zheng, Lei Zhou, Xin Lu, Yidong Luo, Ren-Jie Song
Bimetallic catalysis offers enhanced reactivity, selectivity, and cooperative effects compared to traditional monometallic catalysis. However, the detailed understanding of coordination and metal interactions in such bimetallic systems is still elusive....
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A Divergent Electrochemical Platform for Diazene Radical Generation and C–N Coupling Reactions

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00078A, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Roopam Pandey, Suchismita Rath, Yashika Tyagi, Shivani Jadoni, Tejas Prabakar, Shreemad Patel, Debajit Maiti, Subhabrata Sen
The development of sustainable methods for controlled C-N bond formation remains a central challenge in modern synthesis. Here we report an operationally simple, catalyst-free and acid/base-free electrochemical platform that enables...
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Tunable Ring-Opening of 2H-Azirines via Visible-Light-Driven Novel Selective C-C/C-N or C=N Bond Cleavage

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00168H, Research Article

Bao-Gui Cai, Li-Hua Zhang, Yang Xie, Qiong Zhang, Jun Xuan
The visible-light-induced ring-opening of 2H-azirines has primarily focused on the selective cleavage of individual bonds, such as C–C, C–N, or C=N. However, simultaneous cleavage of multiple bonds, such as both...
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Site-selective iron-catalyzed C-H alkylation of pyrazinones, azauracils and quinoxalinones

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00044D, Research Article

Vaibhav Ramachandra Pansare, Sreelakshmi N, Nagaraju Barsu
The direct C–H alkylation of nitrogen-containing heterocycles is a valuable and widely pursued transformation due to the importance of these scaffolds in pharmaceuticals and bioactive natural products. In this study,...
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Copper-catalyzed B–H bond insertion reaction of triboranes (L·B3H7) with diazo compounds

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00098C, Research Article

Lei Cao, Jiarui Chang, Xi-Meng Chen, Yan-Na Ma, Xuenian Chen
Compared with an enormous amount of reactions of the B-H bond of the Lewis base BH3 adducts, the reactions of the B-H bond of the multinuclear boranes have been less...
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Aryl imidazoisoindoles for intrinsic 10π pericyclic photochromism with nonlinear acid responsiveness

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00016A, Research Article

Taichi Muto, Chigusa Goto, Shohei Katao, Tsuyoshi Kawai
New aryl imidazoisoindoles were synthesized and identified as 10π photochromic systems. Catalytic amounts of acid significantly accelerate the ring-opening reaction, exhibiting nonlinear acid responsiveness.
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Enantioselective synthesis of allylic boronates bearing a stereodefined (E)-alkenyl chloride by Cu-catalyzed borylation of allylic gem-dichlorides

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00061D, Research Article

Open Access

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Andrea Chaves-Pouso, Andrés M. Álvarez-Constantino, Patricia Gómez-Roibás, Martín Fañanás-Mastral
A copper-catalyzed enantioselective and E-selective borylation of allylic gem-dichlorides that affords chiral synthetically versatile γ-chloro substituted allylic boronates is reported.
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A modular approach toward 5,6,7,8-functionalized acepleiadylene derivatives

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01765C, Research Article

Shengchen Wei, Yingjie Peng, Dan Shi, Xiangzhao Zhu, Songhua Chen, Lili Xie, Yuanming Li
π-Extension of acepleiadylene were accomplished at the 5, 6, 7, and 8 positions. Their structural, photophysical, and electronic properties were comprehensively investigated through experiments and theoretical calculations.
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Rh(III)-catalyzed regioselective C6-arylation of 2-pyridones with diazonaphthalen-2(1H)-ones along with directing group migration

Org. Chem. Front., 2026, 13,1595-1601
DOI: 10.1039/D5QO01563D, Research Article

Yuanshuang Xu, Shuya Zhang, Yujing Xiao, Xinying Zhang, Xuesen Fan
Herein, we describe a Rh(III)-catalyzed cascade reaction between 2-pyridones and diazonaphthalen-2(1H)-ones, providing an efficient and convenient synthetic route to 6-(2-(pyridin-2-yloxy)naphthalen-1-yl)pyridin-2(1H)-ones.
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Modular assembly of conformationally dynamic dinaphthocycloocta-1,5-dienes

Org. Chem. Front., 2026, 13,1643-1649
DOI: 10.1039/D5QO01621E, Research Article

Open Access

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Michel Große, Christopher M. Leonhardt, Hermann A. Wegner
A Lewis acid-catalyzed inverse electron-demand Diels–Alder sequence enables the stepwise annulation of naphthalene units onto a cyclooctadiene scaffold, affording conformationally dynamic fused polycycles.
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Outer-sphere reductive elimination as the enantio-determining step in IrIII/NiII metallaphotoredox-catalyzed α-(hetero)aryl amination: a DFT study

Org. Chem. Front., 2026, 13,1551-1559
DOI: 10.1039/D5QO01726B, Research Article

Ya-Bin Jiang, Wei Guan, Yu-Jie Liang
Outer-sphere reductive elimination as the enantio-determining step in Ir^III/Ni^II metallaphotoredox-catalyzed α-(hetero)aryl amination has been theoretically disclosed.
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Benzophenone-catalyzed alkenylative pyridylation of vinylarenes with alkenylboronic esters

Org. Chem. Front., 2026, 13,1675-1680
DOI: 10.1039/D5QO01578B, Research Article

Yuhui Ying, Zixiang Li, Bin Liu
We present a metal-free and gentle three-component reaction for the synthesis of alkenes using benzophenone as a photocatalyst in combination with alkenylboronic esters.
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Substrate-controlled mechanistic switch between protodemetalation and oxidative addition in Rh-catalyzed carbometalation: a DFT study

Org. Chem. Front., 2026, 13,1657-1666
DOI: 10.1039/D5QO01672J, Research Article

Chunhui Shan, Hong Chen, Xiang Zhang, Xiaoling Luo
This DFT study reveals substrate-dependent mechanisms in Rh(I)-catalyzed carbometalation: dihydropyridines undergo insertion/protodemetalation, while dihydroquinolines favor oxidative addition, dictating enantioselectivity at different steps.
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Metal- and additive-free ipso-benzylation of arylsilanes to access diarylmethanes

Org. Chem. Front., 2026, 13,1667-1674
DOI: 10.1039/D5QO01554E, Research Article

Wanting Fu, Jialong Zhong, Shuang Lv, Xinyu Song, Yilin Xing, Zikun Wang
A metal- and additive-free ipso-benzylation of arylsilanes was developed to efficiently synthesize symmetrical and unsymmetrical diarylmethanes.
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DMSO/Tf2O-promoted regio- and Z-stereoselective sulfonyl functionalization of terminal alkynes

Org. Chem. Front., 2026, 13,1566-1572
DOI: 10.1039/D5QO01607J, Research Article

Yuxin Guo, Hanru Tang, Zhiyan Liu, Zhiping Wang, Long-Yong Xie, Jian Wen
We report a DMSO/Tf₂O-promoted regio- and Z-stereoselective sulfonyl functionalization of terminal alkynes that delivers diverse functionalized vinyl sulfones in a highly selective manner under tunable basic conditions.
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Harnessing alkaline-earth metal reactivity: mechanistic insights into alkene and alkyne functionalization via organomagnesium(II) and organobarium(II) catalysis

Org. Chem. Front., 2026, 13,1602-1616
DOI: 10.1039/D5QO01464F, Research Article

Yumiao Ma
A comprehensive in silico exploration establishes fundamental understanding for alkaline-earth catalysis, proving these earth-abundant metals can function as transition-metal mimics with complementary reactivities in migratory insertion reactions.
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Recent advances in earth-abundant transition-metal-catalysed asymmetric oxidative sp3–sp3 cross-couplings

Org. Chem. Front., 2026, 13,1703-1723
DOI: 10.1039/D5QO01749A, Review Article

Jiao He, Perla Bharath Kumar, Yu-Long Li, Qiong Yu, Wei Shu
This review summarizes advances in earth-abundant transition-metal-catalyzed asymmetric oxidative sp³–sp³ cross-couplings, focusing on reaction development, mechanistic insights, synthetic applications, key challenges, and future perspectives.
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Construction of the tricyclic core of rhamnofolane-type diterpenoids

Org. Chem. Front., 2026, 13,1617-1624
DOI: 10.1039/D5QO01699A, Research Article

Zhuang Wang, Zhaoyu Zhang, Xinyu Xie, Song Qin, Shaomin Fu, Bo Liu
Synthesis of the tricyclic core of rhamnofolane-type diterpenoids is reported.
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Divergent oxidative annulation of primary aliphatic amines to access semi-saturated fused pyrimidines or quinazolines

Org. Chem. Front., 2026, 13,1636-1642
DOI: 10.1039/D5QO01676B, Research Article

Kang Liu, Jiaoling Li, Fanqian Li, Xinyi Tang, Xue Peng, Yao-Fu Zeng, Xinping Liu, Guo-Jun Deng, Zhen Wang, Jinjin Chen
A novel multicomponent reaction enables the divergent synthesis of semi-saturated fused pyrimidines and quinazolines from cycloalkylamines, aldehydes and NH₄I via oxidative annulation involving C(sp³)–H functionalization of primary aliphatic amines.
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Enantiodivergent intermolecular hydroamination of acyclic 1,3-dienes using aniline nucleophiles

Org. Chem. Front., 2026, 13,1536-1544
DOI: 10.1039/D5QO01645B, Research Article

Tianlei Ren, Huan Cong
Pd-catalyzed enantioselective intermolecular hydroamination of acyclic 1,3-dienes can proceed with aniline nucleophiles, featuring enantiodivergence via modulation of non-chiral acid additives.
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Synthesis of quinazolinone scaffolds from the cascade reaction of o-aminobenzamides/o-aminobenzonitriles and calcium carbide mediated by K2S

Org. Chem. Front., 2026, 13,1578-1585
DOI: 10.1039/D5QO01490E, Research Article

Shuyi Li, Yunzhe Du, Ligang Yan, Siliu Cheng, Shuang Cao, Ruijun Xie, Limin Han, Ning Zhu
K₂S-mediated one-pot synthesis of quinazolinones or dihydroquinazolinones from o-aminobenzamides (or o-aminobenzonitriles) and calcium carbide offers a cost-effective and sustainable alternative.
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Palladium-catalyzed four-component cascade cyclization and carbonylation of bicyclobutyl (BCB) amides

Org. Chem. Front., 2026, 13,1625-1629
DOI: 10.1039/D5QO01673H, Research Article

Jianwei Wang, Chunxue Pu, Jianfeng Xu, Yan Cao, Wei Chen, Jun Ying
A novel palladium-catalyzed four-component cascade cyclization and carbonylation of bicyclobutyl (BCB) amides has been developed for the rapid construction of functionalized spiroquinolinone scaffolds.
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Scandium-catalyzed asymmetric addition of allenylsilanes to β,γ-unsaturated α-ketoesters: enantioselective synthesis of tertiary homopropargylic allylic alcohols

Org. Chem. Front., 2026, 13,1531-1535
DOI: 10.1039/D5QO01584G, Research Article

Linxuan Wang, Xiangqing Jia, Chen-Ho Tung, Zhenghu Xu
A scandium catalyzed regio- and enantioselective 1,2-homopropargylic addition of β,γ-unsaturated α-ketoesters was demonstrated, affording enantioenriched tertiary homopropargylic allylic alcohols in good yields with excellent enantioselectivities.
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Photocatalytic 3D skeletal editing of carboxylic acids via [4 + 1] cyclization for streamlined synthesis of unsaturated γ-lactams

Org. Chem. Front., 2026, 13,1681-1687
DOI: 10.1039/D5QO01548K, Research Article

Jiahui Yu, Xiaohong Li, Liangbin Huang
Herein, we report a photocatalytic strategy for the three-dimensional skeletal editing of carboxylic acids via sequential deoxygenation. It converts structurally diverse carboxylic acids into biologically unsaturated γ-lactams.
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Palladium(II)-catalyzed substrate-controlled diastereoselective formal (3 + 3) allylic annulation of 2- or 3-substituted 4-hydroxy-but-2-en-1-yl acetates

Org. Chem. Front., 2026, 13,1545-1550
DOI: 10.1039/D5QO01637A, Research Article

Tuanli Yao, Nan Yang, Jun-E. She, Xiangyang Qin
We report a palladium(II)-catalyzed (3 + 3) allylic annulation between 2-(1-alkynyl)-2-alken-1-ones and 2- or 3-substituted (Z)-4-hydroxy-but-2-en-1-yl acetates.
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Pd(II)-catalyzed atroposelective C–H olefination to access [n]naphthalenophanes

Org. Chem. Front., 2026, 13,1523-1530
DOI: 10.1039/D5QO01614B, Research Article

Xiaoyu Wang, Jia Li, Quan Tang, Changgui Zhao
A Pd-catalyzed late-stage C–H olefination of [n]naphthalenophanes has been developed.
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Piezocatalyzed cascade cyclization of 1,7-enynes with α-keto acids under ball milling

Org. Chem. Front., 2026, 13,1586-1594
DOI: 10.1039/D5QO01278C, Research Article

Yashuang Liu, Heng Li, Yan Liu, Bingxin Yuan
Mechanochemical, piezoelectric-catalyzed decarboxylative cascade cyclization of 1,7-enynes with α-keto acids.
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Syntheses of 1,2,3-functionalized naphthols and phenols by decarboxylative cycloaddition/aromatization reactions of α-oxygenated lactones with allenoates or electron-deficient alkynes

Org. Chem. Front., 2026, 13,1573-1577
DOI: 10.1039/D5QO01582K, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mohammad Sadeq Mousavi, Antonio Massa, Mario Waser
Cycloadditions between hydroxypyrones or isochroman-3,4-diones and allenoates or butynoates allow for the direct synthesis of various 1,2,3-substituted phenols and naphthols.
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Rh(III)-catalysed [4 + 2] annulation of N-arylpyrazolones with iodonium ylides: access to fused cinnolines

Org. Chem. Front., 2026, 13,1630-1635
DOI: 10.1039/D5QO01414J, Research Article

Xiaoting Chen, Chaoyu Wang, Xiujuan Zheng, Yadong Feng, Junjie Ma, Xiuling Cui
An efficient synthesis of fused cinnolines via Rh(III)-catalysed [4 + 2] annulation of N-aryl pyrazolones with iodonium ylides was developed. The titled compounds exhibit strong fluorescence, enabling their potential application as probes.
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Transition metal-catalyzed selective hydroalkynylation of internal alkynes with terminal alkynes

Org. Chem. Front., 2026, 13,1688-1702
DOI: 10.1039/D5QO01640A, Review Article

Jun-Fei Wang, Ping Tian, Yun-Xuan Tan
This review highlights recent advances in transition-metal-catalyzed hydroalkynylation of internal alkynes, outlining emerging strategies and future prospects.
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Palladium-catalysed aminocarbonylation of aryl thianthrenium salts to aryl carboxamides using Mo(CO)6 as a CO source

Org. Chem. Front., 2026, 13,1650-1656
DOI: 10.1039/D5QO01508A, Research Article

Zhuo Chen, Hui-Qiang Li, Shun-Bin Xu, Ling-Rui Zhou, Tong-Ling Qin, Wen-Xia Hu, Tao Li, Ruo-Yi Hou, Zi-Yu Lin, E Tang
A safe, mild, and palladium-catalysed aminocarbonylation reaction between aryl thianthrenium salts and various amines, using Mo(CO)₆ as a solid CO surrogate, has been developed.
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Tandem indium(III)-catalyzed cyclization and intermolecular hydrofunctionalization of 1,6-enynes

Org. Chem. Front., 2026, 13,1560-1565
DOI: 10.1039/D5QO01388G, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Raquel Pérez-Guevara, Diego Folgueira-Iravedra, Lorena Alonso-Marañón, M. Montserrat Martínez, José Pérez Sestelo
The stereoselective synthesis of carbo- and heterocyclic frameworks is accomplished by tandem indium-catalyzed cyclization and intramolecular hydrofunctionalization of 1,6-enynes.
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Electrochemically driven reductive coupling of nitroarenes with alkyl bromides

Org. Chem. Front., 2026, 13,1517-1522
DOI: 10.1039/D5QO01269D, Research Article

Xiaoli Su, Wei Wei, Zhaojun Ding, Jiazan Li, Jinlian Li, Jiayu Mo
A metal-catalyst-free electrochemical method for the synthesis of tertiary amines from nitroarenes and alkyl bromides was developed.
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EtAlCl2 -Promoted Defluorinative Thiolation of α-Trifluoromethyl Alkenes

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00011H, Research Article

Xin Guo, Guoliang Pu, Long Xiao, Jiarui Liang, Hang Zhang, Yu Chen, Yang Huang, Qiuli Yao, Chun-Yang He
Here, we report a EtAlCl2-promoted thiolation of trifluoromethyl alkenes, which leads to the complete substitution of all three fluorine atoms and affords trisubstituted products. Although the transformation proceeds through a...
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Photocatalyzed regioselective arylation of trialkylamines

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D5QO01719J, Research Article

Jiamin Wu, Xin Wang, Kuai Wang, Ling-Guo Meng
Easily available trialkylamines are increasingly utilized as coupling partners with diverse hydrocarbons to construct various complicated amine frameworks. However, controlling the regioselectivity of these reactions remains a significant challenge. We...
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Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D5QO01481F, Research Article

Long-Jin Zhong, Xuan Shang, Pengfei Huang, Quan Zhou, Changhui Liu, Yu Liu
We report a study on the use of ligated boryl radicals for the synthesis of nitrogen-containing polycyclic compounds under photocatalytic conditions through a halogen-atom transfer (XAT) strategy. This approach leverages...
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Cu(I)-catalyzed, N-Fluorobenzamides Enabling 1,2-Carbofluorination of Unactivated Alkenes via Free Radical Relay

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D5QO01763G, Research Article

Hong Ji, Haifeng Qiao, Boyi Wang, Tianyu Lu, Weixing Chang, Lingyan Liu, Jing Li
The construction of carbon-fluorine bond has always remained challenging. This work described a two-component 1,2carbofluorination bifunctionalization of unactivated alkenes through a free radical relay process. The N-fluorobenzamide was firstly used...
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Enantioselective synthesis of atropisomeric biaryls and heterobiaryls via transition metal-catalyzed cyclization

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01492A, Review Article

Shibo Lin, Ya Zou, Yiwen Chu, Junfeng Deng, Lifeng Zhao
Atropisomeric architectures with a chiral axis are prevalent in biologically active molecules and natural products, and they are widely put to use in privileged catalysts and chiral ligands.
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B-spiroBODIPYs as a fluorophore responsive to hydrogen bond donors

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00102E, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Aiko Kondo, Hideaki Takano, Hiroshi Shinokubo
We demonstrate an Au-catalysed synthesis of B-spiroBODIPYs with a 1,3-dioxinone moiety. The B-spiroBODIPY exhibits solvent-dependent fluorescence arising from hydrogen-bonding interactions, which offers a platform for stimulus-responsive probes.
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Palladium/copper bimetallic system-catalyzed cascade cyclization of N-allyl ynamides and o-haloanilines: access to multifunctional benzimidazoles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00038J, Research Article

Yi-Yun Zhang, Xu-Heng Yang, Ai-Ming Wen, Fang Wang, Jian Huang, Jianfang Wang, Cheng-an Tao
A one-pot synthesis of 1,2-disubstituted multifunctional benzimidazole derivatives starting from N-allyl ynamides and o-haloanilines has been introduced. The reaction could also be performed on a multi-gram scale with the same efficiency.
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α-Functionalization of ethers with acridanes and amines via metal-free direct C(sp3)–H radical–radical cross-dehydrogenative coupling

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00065G, Research Article

Sudip Karmakar, Sumit Das, Koushik Naskar, Imtiaj Mondal, Moumita Chowdhury, Ronaldo Nongmaithem, Indubhusan Deb
A metal-free radical–radical cross-dehydrogenative coupling of the relatively inert C(sp³)–H bond of ethers with the C(sp³)–H bond of acridanes and amines has been developed, enabling the synthesis of C9-etherified acridanes and α-etherified amines.
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Organocatalytic asymmetric synthesis of fluorinated pyranopyrazoles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00005C, Research Article

Jianfeng Mu, Aining Dong, Menghan Yang, Hongyu Zhang, Guoshun Zhang, Xiaochen Wang, Bei Wei, Shurong Ban
Asymmetric fluorinated pyranopyrazoles were successfully constructed with good yields and high enantioselectivityvia the reaction of unsaturated pyrazolones with α-trifluoromethyl β-fluorinated gem-diols.
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Engineering Tetraphenylethene-Based Z and E Stereoisomers: Structural Analysis and Sensing Application

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00075D, Research Article

Han-Jiang Yang, Yatuan Ma, Xinpei Zhong, Xin Yang, You Xu, Xiaoxue Zhang, Zhixin Xiang, Xiujuan Huang, Wenji Wang, Jinyi Wang, Maosen Yuan
The exploration of Z/E stereoisomers represents an interesting and significant endeavor in molecular engineering. We developed three pairs of tetraphenylethylene (TPE) derivatives modified by heteroatom-containing trivalent arylboron and/or tris(2-methylpyridyl)amine (TPA)...
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Oxidation Reactions in the Current Total Synthesis of Natural Products

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D6QO00050A, Review Article

Jian-Feng Zheng, Anqi Chen, Yan-Jiao Gao, Pei-Qiang Huang
Oxidation and oxidative reactions are a type of fundamental transformation in organic chemistry, which are indispensable for organic synthesis, especially for the total synthesis of natural products. Although there are...
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Polysubstituted bicyclo-[2.1.1]-hexanes as benzene isosteres for medicinal chemistry

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01662B, Review Article

Eugenio Roà, Quentin Lefebvre
This comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.
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Group 14 heavier 1,4-dimetallabenzenes: influence of aromaticity, open-shell character and strain on small molecule activation

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00006A, Research Article

Daniel González-Pinardo, Israel Fernández
The influence of the aromaticity, diradical character and strain on the reactivity of group 14 heavier 1,4-dimetallabenzenes (E = Si, Ge, Sn, Pb) has been investigated using quantum-chemical calculations.
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Pyrazolium-ylide [3 + 2] cycloaddition/oxidative aromatization for the construction of 1H-pyrrolo[1,2-b]pyrazoles

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00070C, Research Article

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Motohiro Yasui, Tatsuya Tsumori, Masato Morita, Shigeyuki Yamada, Tsutomu Konno
Cycloaddition of pyrazolium ylides with alkynes, followed by in situ oxidation, enabled access to 1H-pyrrolo[1,2-b]pyrazole derivatives, 5/5-fused 10π N-heteroarenes. The reaction pathways were elucidated by DFT calculations.
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Pd(PPh3)4-catalyzed regioselective C–H para-allylation of N,N-dialkylanilines using vinyl benzoxazinanones

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00093B, Research Article

Lu Pei, Xiao-Lin Liu, Ding-Jun Zhang, Hui-Hong Tian, Ling-Dan Zhu, Bang-Guo Wei
A Pd(PPh₃)₄-catalyzed regioselective C–H para-allylation process was developed for the reaction of N,N-dialkylanilines with vinyl benzoxazinanones. A series of N,N-dialkylaniline derivatives were excellently synthesized.
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Cross-electrophile stannylation of alkyl triflates and halides with chlorostannanes enabled by Cr(II)-phenanthroline catalysis

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00058D, Research Article

Jiwei Yi, Shuaiyong Zhao, Hongxiang Li, Xiaoyu Zhang, Zhaowen Dong, Xiaoming Zeng
Cross-electrophile stannylation of alkyl electrophiles with chlorostannanes was enabled by phenanthroline-ligated Cr(II) catalysis, offering a mild, step-economical route to α-functionalized alkyltin reagents in one step.
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Interactions beyond H-bond: Unveiling the role of unorthodox non-covalent interactions in charged thiourea and its catalytic efficiency

Org. Chem. Front., 2026, Accepted Manuscript
DOI: 10.1039/D5QO01735A, Research Article

Prabhahar Murugan, Parul Rathour, Dipankar Das, Brijesh Patel, Srinu Tothadi, Biswajit Ganguly, Saravanan Subramanian
The development of catalyst with a rapid turnover rate under ambient reaction condition is highly desired. Inspired by the biocatalytic systems, the field of charge-driven catalysis provide useful guidelines for...
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An air-stable chiral P,N-ligand/PdCl2 partner enables a highly enantioselective oxidative homocoupling of naphthylboronic acids/boronates only in an oxygen atmosphere

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01752A, Research Article

Guo Cheng, Jing-Liang Yu, Qian-Mao Zhang, Zhen-Yu Yang, Fang Tian, Li-Xin Wang
A highly enantioselective oxidative homocoupling of naphthylboronic acids/boronates was achieved for the first time in the presence of an easily available chiral P,N-ligand/PdCl₂ complex only in an oxygen atmosphere at high temperature conditions.
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One-pot dearomatizative telescoped addition of C-nucleophiles to fluorinated 1,2,4-oxadiazoles followed by regioselective N-functionalization

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01707F, Research Article

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Davide Castiglione, Sara Amata, Federica Lauria, Andrea Maranzana, Salvatore Baldino, Alexander Prado-Roller, Laura Castoldi, Antonio Palumbo Piccionello, Vittorio Pace, Eisuke I. Comas Iwasita
The constitutive low aromaticity of easily accessible 5-trifluoromethyl-1,2,4-oxadiazoles is explored to enable editing modification to the corresponding unprecedented gem-disubstituted 1,2,4-oxadiazolines.
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Advances in the construction of boryl cyclobutanes

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00008H, Review Article

Kanak Kanti Das, Sutapa Dey
Recent advances in the synthesis of boryl-substituted cyclobutanes are summarized, highlighting strain-release, boronate complex reactivity, 1,2-migration, and catalytic strategies for stereocontrolled access to sp³-rich building blocks.
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Phosphorothiosulfonates: new radical phosphorothiolation reagents for photocatalytic cyclization of alkenes/alkynes

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00063K, Research Article

Xiang Liu, Mingyang Chen, Peng Liao, Yitai Fu, Qian Wang, Yan-Long Ma, Hua Cao
We report the first synthesis of phosphorothiosulfonates as competent radical –S–P(O)(OR)₂ precursors. Under mild photoredox conditions, these reagents enable metal-, oxidant-free phosphorothiolation/cyclization of diverse alkenes and alkynes.
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Synergistic experimental and theoretical investigation of carbazole–cyanopyridine-based hole-transporting materials

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00076B, Research Article

Rachel Chetri, Vygintas Jankauskas, Gediminas Kreiza, Kasparas Rakstys, Vytautas Getautis, Rahim Ghadari, Arijit Saha, Ahipa Tantri Nagaraja
This work highlights the design, synthesis, and characterization of three new hole-transporting materials (DJ01-alkyl, PR01-alkyl, and PM01-alkyl) based on donor–acceptor–donor (D–A–D) and acceptor–acceptor–donor (A–A–D) concepts.
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Guest-dependent folding and tunable charge transfer of an NDI-pentamer

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00055J, Research Article

Open Access

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Dhanyashree Das, Dhrubajyoti Talukdar, Bappaditya Gole
Here we report a covalently linked, conformationally flexible naphthalene diimide (NDI) pentamer that exhibits unprecedented solvent- and guest-dependent folding and tunable charge-transfer (CT) interactions with polyaromatic guests.
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Tricarbazole-based donor–acceptor architectures with diverse acceptors: synthesis, properties and applications

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01633A, Research Article

Huabi Xie, Yu Zuo, Chengye Yuan, Peng Xu, Ningwen Sun, Hongxing Jia, Jinjin Ding, Qiang Huang, Jinling Zhang
Using tricarbazole as an electron donor and aromatic rings with distinct electron cloud density as acceptors, a series of donor–acceptor architectures were constructed, achieving highly sensitive detection of epinephrine.
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Tunable CTPhos and chloride enabled direct asymmetric reductive amination for the synthesis of chiral hydroxylamines

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00012F, Research Article

Qishan Liu, Wenji Wang, Biying Liu, Haizhou Huang, Mingxin Chang
The highly modulated and adjustable CTPhos ligands and the chloride anion show excellent enantioselectivity in the first example of direct asymmetric reductive amination of ketones and both N–H and N-alkyl hydroxylamines.
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Visible light-induced regioselective/dehydrogenative C–H silylation of (thio)chromones via a tricatalytic process

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00081A, Research Article

Shou-Cai Wang, Zi-Ren Chen, Fei Xue, Yong-Hong Zhang, Bin Wang, Shao-Feng Wu, Yu Xia, Weiwei Jin, Fanghua Ji, Chenjiang Liu
A mild, regioselective C–H silylation of (thio)chromones via synergistic HAT/photoredox/Ni catalysis under air, with H₂ as sole byproduct and excellent functional-group tolerance.
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Theoretical investigation on the mechanism of Ni0(acetylide carbanion)-ate complex-catalyzed C(sp2)–F bond activation and the origin of the counterion effect on reactivity

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01757B, Research Article

Xiao-Xia You, Ling-Qi Meng, Xu Liu, Li-Li Wang, Xin-Cheng Xu, Rong-Lin Zhong, Zhong-Min Su
DFT calculations reveal that C(sp²)–F bond activation proceeds via an inner-sphere Ni⁰-mediated S_NAr pathway enabled by a Ni⁰(acetylide carbanion)-ate complex, where acetylide coordination enhances nucleophilicity at the Ni⁰ center.
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Cobalt-catalyzed C–H annulation of aliphatic amides with maleimides: chemodivergent (4 + 1) and (3 + 2) pathways

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00080K, Research Article

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Celia Sánchez-González, Juan C. Carretero, Inés Alonso, Nuria Rodríguez, Javier Adrio
Chemodivergent C–H annulation of aliphatic amides with maleimides has been achieved under cobalt-catalysis, enabling access to distinct (4 + 1) and (3 + 2) outcomes.
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Palladium-catalyzed allylation of stable glycal boronates to access multi-substituted C1-glycals: en route to the construction of a spirocyclic core of benthol A

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00107F, Research Article

Hong-Rao Ma, Tao Li, Xiao-Qin Zhou, Xiu-Mei Li, Lin Peng, Liang-Liang Wang
A series of C1-allyl glycals were synthesized by a palladium catalyzed allylation reaction under mild conditions.
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Diastereoselective synthesis of dioxaadamantane skeletons from coumarin-fused bridged ketones via a triple Grignard addition and hydroalkoxylation sequence

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01594D, Research Article

Haoran Yang, Jiawei Liu, Changmeng Yang, Dunru Zhu, Ruwei Shen
A sequential protocol involving triple allylic Grignard addition to coumarin-fused bridged ketones, followed by C–O bond-forming cyclization, is developed to access chromane-annulated dioxaadamantane skeletons with excellent diastereoselectivity.
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Asymmetric C3-allenylation of carbazoles with α-indolyl propargylic alcohols

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01692D, Research Article

Xiao-Yi Deng, Yun-Zhe Li, Zhong Xie, Wen-Run Zhu, Yi Liu, Gui Lu, Jiang Weng
A chiral phosphoric acid-catalyzed asymmetric mono- and double-allenylation of carbazoles with α-indolyl propargylic alcohols was realized.
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Pd(II)-catalyzed aerobic dual C–N bond formation: oxygen-dependent divergence between dihydroquinazolinone and aza-Michael pathways, an experimental and computational study

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01381J, Research Article

Narges Mohammadi, Farnaz Jafarpour, Leyla Mohammadkhani, Alireza Ariafard
A selective, eco-friendly aerobic Pd(II)-catalyzed three-component reaction in water converts isatoic anhydrides, anilines, and acrylamides to dihydroquinazolin-4(1H)-ones. Without O₂, the pathway switches to an aza-Michael adduct.
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N-Pechmann aza-BODIPYs: enhanced near-infrared photothermal conversion by the cross-conjugated structure

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00024J, Research Article

Yuma Tanaka, Yuya Taninokuchi, Taichi Sawamura, Saori Okamura, Shigeki Mori, Masatoshi Ishida, Koji Miki, Kouichi Ohe, Takanori Iwasaki, Soji Shimizu
A novel near-infrared (NIR) photothermal material, NPAB-55, was developed using an N-Pechmann dye. NPAB-55 nanoparticles exhibited high photothermal conversion, photoacoustic response, and photothermal cytotoxicity upon NIR illumination.
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Rhenium-catalyzed stereoselective hydrocarboxylation of alkynes and olefins: late-stage NSAID drug's diversification

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01612F, Research Article

Suman Bhowmick, Mayank Singh, Khushboo Tiwari, Dharmendra Kumar Tiwari
A rhenium-catalyzed, highly efficient, regio- and stereoselective hydrocarboxylation of internal alkynes and olefins has been developed. Notably, several NSAID drug molecules underwent hydrocarboxylation without the need for pre-functionalization.
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Electronic properties of diastereomeric Möbius shaped cyclotris[5]helicenes

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01741F, Research Article

Open Access

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Albert Artigas, Nicolas Vanthuyne, Jean-Valère Naubron, Denis Hagebaum-Reignier, Yannick Carissan, Maxime Rémond, Ludovic Favereau, Harald Bock, Fabien Durola, Yoann Coquerel
The conformational, (chir)optical and aromatic properties of singly and triply twisted Möbius-shaped cyclotris[5]helicenes are scrutinized.
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Electrochemical deuteration of allylic esters with divergent site-selectivity

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01759A, Research Article

Xu Zhang, Ke Liu, Mohan Wang, Chao Wu, Xiaoli Wang, Man-Bo Li, Sheng Zhang
Deuterium-labelling technology has emerged as a promising new direction for drug discovery.
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Organocatalytic enantioselective C–H allenylation of carbazoles with propargylic alcohols via remote 1,8-conjugate addition

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00064A, Research Article

Xiaoyi Deng, Hanzhuo Huang, Jun Huang, Gong Chen, Yi Liu, Jiang Weng, Wenrun Zhu
An efficient method for the remote asymmetric C–H allenylation of carbazoles with propargylic alcohols via 1,8-conjugate addition has been developed.
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Pd(II)-catalyzed intramolecular diarylation of alkynes via dual C–H activation: modular access to azafulvalene-based bis(polycyclic) aromatic enes

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01688F, Research Article

Open Access

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Tienan Jin, Sho Aida, Takuma Sato, Masahiro Terada
Structurally diverse azafulvalene-based bis(polycyclic) aromatic enes with precisely positioned nitrogen atoms were synthesized from N-aryl and 2-aryl biarylalkynyl indoles via Pd-catalyzed dual aromatic C–H activation.
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CHA-initiated [3 + 2 + 1] spiroannulation of enaminone with diazo oxindole leading to a concise and divergent synthesis of oxindole spirohydropyridines

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01702E, Research Article

Pengkuo Shi, Chun Yang, Nana Shen, Haiyun Xu, Xinying Zhang, Xuesen Fan
Presented herein is a concise and selective construction of diverse spirohydropyridine skeletons along with the simultaneous introduction of an oxindole moiety based on the CHA-initiated cascade reaction of an enaminone with a diazo oxindole.
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A direct method for phosphorus atom insertion via phosphorous acid for synthesizing P-doped curved polycyclic π-systems

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01428J, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Tomohiro Higashino, Yoshifumi Nishida, Keiichi Ishida, Shunsuke Kozaka, Yuka Yasuda, Hironori Kaji, Hiroshi Imahori
A metal-free and direct method for the insertion of phosphorus atoms into π-frameworks using H₃PO₃ has been developed, providing a simple and straightforward approach to synthesize P-doped curved polycyclic π-systems.
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Amine-cation-driven heteroannulation of halomaleimides with C–N cleavage: metal-free access to heterobicyclic frameworks

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D6QO00010J, Research Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Luka Ciber, Helena Brodnik, Nejc Petek, Jurij Svete, Uroš Grošelj, Bogdan Štefane
Mild synthesis of 3,4-diamin-substituted maleimide heterobicycles in synthetically useful yields via a crucial quaternary enamine intermediate.
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A photoswitchable tetra-azo macrocycle enabling light-controlled host-in-host binding and release of cucurbit[5]uril

Org. Chem. Front., 2026, Advance Article
DOI: 10.1039/D5QO01751C, Research Article

Yue Wu, Kuirong Fu, Song Qin, Ming Ouyang, Zhiyao Yang, Yimin Cai, Wen Feng, Lihua Yuan, Xiaowei Li
A photoisomerizable hydrogen-bonded tetra-azo macrocycle with a figure-of-eight conformation enables light-controlled binding and release of CB[5] within its amide oxygen-decorated cavity.
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Dimethylamino-iodine(III)/PPh3-mediated synthesis of α-ketoamides from glyoxylic acids

Org. Chem. Front., 2026, 13,1309-1316
DOI: 10.1039/D5QO01675D, Research Article

Dan Xiao, Jiaxin He, Kaiyue Yang, Zhijian Wang, Cong Li, Yunfei Du
A mild and metal-free method for the preparation of α-ketoamides from glyoxylic acids, mediated by a dimethylamino-iodine(III)/PPh₃ system.
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EDA-complex photoactivation of thianthrene-based radical precursors enables divergent access to functionalized saturated heterocycles

Org. Chem. Front., 2026, 13,1116-1124
DOI: 10.1039/D5QO01397F, Research Article

Yingmin Ji, Roser Pleixats, Israel Fernández, Carolina Gimbert-Suriñach, Adelina Vallribera, Albert Granados
Electron-accepting thianthrenium and iminothianthrene species form EDA complexes with alkenoic substrates through π interactions, enabling a multibond-forming cascade that constructs diverse heterocycles.
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β-Selective Heck reactions of unprotected allylamines driven by surface charge of in situ-formed Pd nanoparticles

Org. Chem. Front., 2026, 13,1263-1274
DOI: 10.1039/D5QO01463H, Research Article

Kendra K. Shrestha, Olutayo N. Farinde, Abigail M. Gohmann, Radha Kondapalli, Oreoluwa Adeyemo, Vanaparthi Satheesh, Justin M. Maxwell, Vinod G. Landge, Allison V. Gottshall, G. Brant Hunt, Michael C. Young
Arylation of allylamines typically favors addition of the new aryl at the γ-position via an insertion mechanism. However, by using a relatively electronically neutral reduced metal nanoparticle, the selectivity of this reaction can be switched to β.
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Precision synthesis of peptide chimeras through site-specific azomethine ylide–dehydroalanine cycloaddition

Org. Chem. Front., 2026, 13,1317-1327
DOI: 10.1039/D5QO01627D, Research Article

Masaki Iwata, Yuzuki Takami, Sena Miura, Hibiki Ohno, Eunsang Kwon, Naohiko Yoshikai, Kazuya Kanemoto
An Ag-catalyzed N-terminus/dehydroalanine [3 + 2] cycloaddition enables site-specific peptide–peptide conjugation. Chiral (S)- and (R)-DTBM-SEGPHOS ligands control pyrrolidine stereochemistry independently of the peptide backbone.
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Multigram synthesis and physicochemical evaluation of (oxa)azaspiro[2.n]alkane building blocks

Org. Chem. Front., 2026, 13,1106-1115
DOI: 10.1039/D5QO01505G, Research Article

Sergiy Galavskyy, Anton V. Chernykh, Daria S. Klymenko, Oleksandr S. Liashuk, Svetlana V. Shishkina, Dmytro Lesyk, Pavlo Nosyk, Valeriya Makhankova, Petro Borysko, Dmytro M. Volochnyuk, Serhiy V. Ryabukhin, Oleksandr O. Grygorenko
Multigram synthesis and physicocochemical characterization of (oxa)azaspiro[2.n]alkane derivatives – promising scaffolds for drug discovery – are reported.
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Dithiofunctionalization: a versatile approach for constructing complex disulfides from alkenes and alkynes

Org. Chem. Front., 2026, 13,1299-1308
DOI: 10.1039/D5QO01625H, Research Article

Yuzuki Takami, Eunsang Kwon, Kazuya Kanemoto
An acid-mediated dithiocyclization strategy using N-(morpholine-4-dithio)phthalimide enables the modular synthesis of heterocycle-appended unsymmetrical disulfides from a broad range of alkynes and olefins.
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Direct construction of high-value pyridine scaffolds through manganese-promoted alkene dicarbofunctionalization

Org. Chem. Front., 2026, 13,1328-1336
DOI: 10.1039/D5QO01424G, Research Article

Ming-Yu Chen, Pierre-Adrien Payard, Marie-Eve L. Perrin, Julien C. Vantourout
A versatile Mn-mediated dicarbofunctionalization enables efficient access to pharmaceutically relevant γ-heterocyclic ketones, α-tetralones, tetrahydroquinolines and benz[h]isoquinolines. An electrochemical alternative reduces Mn usage.
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Visible light-induced C–H alkylation of 1,2,4-triazine-3,5(2H,4H)-diones using hypervalent iodine reagents as alkylating sources

Org. Chem. Front., 2026, 13,1253-1262
DOI: 10.1039/D5QO01585E, Research Article

Qun-Qun Tian, Wenbo Song, Hong-Yu Zhang, Yuecheng Zhang, Jiquan Zhao
A catalyst-free and metal-free C–H alkylation reaction of 1,2,4-triazin-3,5-diones using iodo-methylphthalate esters proceeds under mild conditions, enabling efficient and scalable synthesis in a microfluidic reactor.
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Direct alkylation of quinolines with organolithium-activated 1,1-diborylalkanes

Org. Chem. Front., 2026, 13,1292-1298
DOI: 10.1039/D5QO01448D, Research Article

Woohyun Jo, Changsu Ryu, Jung Woon Yang, Seung Hwan Cho
We report a regioselective alkylation of quinolines enabled by activation of 1,1-diborylalkanes with organolithiums.
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Late-stage defluorinative functionalization: synthesis of thio-amides and heterocycles from trifluoromethylarenes

Org. Chem. Front., 2026, 13,1275-1280
DOI: 10.1039/D5QO01574J, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Marcus Söderström, Esther Olaniran Håkansson, Luke R. Odell
The first general method for CF₃-to-thioamide and CF₃-to-heterocycle transformations is presented.
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TBADT/nickel co-catalyzed arylation of hydrosilanes with aryl halides

Org. Chem. Front., 2026, 13,1125-1130
DOI: 10.1039/D5QO01479D, Research Article

Kaixin Fu, Zilong Yan, Yong Lu, Zhaolin Fu, Weiping Zheng, Shuanhu Gao, Shengchao Yang, Dong Xing
Here we report a nickel/photo co-catalyzed direct radical Si–H arylation of hydrosilanes with aryl halides.
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Brønsted acid-catalyzed synthesis of trifluoromethylated azulenes via cyclization of 1-phenyl-2-CF3-1,3-enynes

Org. Chem. Front., 2026, 13,1151-1158
DOI: 10.1039/D5QO01617G, Research Article

Wuding Sun, Jimin Yang, Kai Di, Luyang Sun, Shuhui Xu, Dong Li, Jinfeng Zhao, Jingping Qu, Yi Luo, Yuhan Zhou
Brønsted acid-catalyzed annulation provides a mild, metal-free route to valuable trifluoromethylated azulenes rapidly.
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Photoredox catalyzed visible light-induced reduction of nitroarenes into anilines

Org. Chem. Front., 2026, 13,1245-1252
DOI: 10.1039/D5QO01565K, Research Article

Weiqiang Sun, Hao Guo, Aishun Ding
A photochemical methodology was developed for the reduction of nitroarenes, utilizing γ-terpinene as the reductant and 9-HTX⁻ as the photocatalyst.
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Ligand-controlled copper-catalyzed carboamination reactions of styrenes and 1,3-enynes to access diverse imides

Org. Chem. Front., 2026, 13,1211-1217
DOI: 10.1039/D5QO01504A, Research Article

Qi-Xuan Jiang, Kai Xiao, Wei Huang, Feng-Hua Zhang
The multi-component reaction among alkenes, nitriles and carboxylic acids via the radical Ritter-type process is one of the most convenient and efficient methods for obtaining imides.
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Photoinduced iridium-cobaloxime mediated alkene C(sp2)–CF2H cross-coupling: difluoromethylation of ketene dithioacetals

Org. Chem. Front., 2026, 13,1232-1238
DOI: 10.1039/D5QO01628B, Research Article

Baoping Ren, Long Sun, Junsheng Zhi, Qun Liu, Yifei Li, Ling Pan
Photoinduced difluoromethylation of ketene dithioacetals under mild conditions has been developed, realizing the challenging alkene C(sp²)–CF₂H cross-coupling reaction and mechanistically proving the crucial role of cobaloxime under mild conditions.
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Isoquinoline-catalyzed visible-light-mediated 1,2-/1,4-thiosulfonylation difunctionalization reaction of thiosulfates with alkenes

Org. Chem. Front., 2026, 13,1138-1143
DOI: 10.1039/D5QO01570G, Research Article

Molai Zhao, Yang Fu, Min Peng, Yawen Wang, Hezhong Jiang, Chuan-Hua Qu, Jiahong Li, Rui Tan
We have developed a novel method for the 1,2-/1,4-thiosulfonylation bifunctional reaction of thiosulfates with non-aromatic olefins.
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A versatile and practical one-pot strategy for a greener, waste-minimized synthesis of aryloxy- and alkyloxy-substituted metallophthalocyanines via tandem SNAr-cyclotetramerization

Org. Chem. Front., 2026, 13,1199-1210
DOI: 10.1039/D5QO01267H, Research Article

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Federica Palmeri, Venanzio Raglione, Laura Mancini, Gloria Zanotti
A sustainable one-pot S_NAr-cyclotetramerization reaction affords metallophthalocyanines with broad functional group tolerance, higher efficiency, and ≥90% lower E-factors than the literature values.
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Theoretical insight: dual roles of electron-pair donors and acceptors in activating and mediating iodine atom transfer

Org. Chem. Front., 2026, 13,1281-1291
DOI: 10.1039/D5QO01593F, Research Article

Taiming Bai, Ming Lei, Hui Li
A DFT study of Lb–BH₂⁺-mediated C–I activation, Lb–BH₂˙-facilitated XAT and alkyl radical generation, and [Cu(II)]-mediated C–N bond formation through combined one-electron oxidation and two-electron reduction.
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Dehydrogenative aromatization of cyclohexanone derivatives for the synthesis of site-selective substituted phenols and anilines

Org. Chem. Front., 2026, 13,1481-1504
DOI: 10.1039/D5QO01442E, Review Article

Dahong Jiang, Quanfeng Liang, Haiqing Li, Fang Fan
Recent research progress concerning the oxidative and acceptorless dehydrogenative aromatization of cyclohexanone derivatives for synthesizing substituted phenols and anilines.
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Visible light-driven construction of isoxazoline/isoxazole scaffolds via [2 + 2 + 1] cyclization of alkenes with tert-butyl nitrite

Org. Chem. Front., 2026, 13,1144-1150
DOI: 10.1039/D5QO01546D, Research Article

Yanfu Jiang, Jiantao Zhang, Xian Jiang, Renhua Su, Liuzhuang Xing, Xin Yang, Weibing Liu
We reported a visible light-driven [2 + 2 + 1] cyclization of alkenes with tert-butyl nitrite for the efficient construction of isoxazoline/isoxazole scaffolds.
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Preparation and catalytic properties of benziodolium salts

Org. Chem. Front., 2026, 13,1239-1244
DOI: 10.1039/D5QO01379H, Research Article

Haruhi Hirai, Akira Tsubouchi, Kazunori Miyamoto, Akira Yoshimura, Akio Saito
The newly developed catalyst was found to exhibit reactivity not observed in conventional iodine(III)-type XB donors due to its unsymmetrical structure.
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Multi-site thiolation enables rapid and precise synthesis of 2-pyridone thioethers

Org. Chem. Front., 2026, 13,1189-1198
DOI: 10.1039/D5QO01352F, Research Article

Xingchi Li, Taoyuan Liang, Guan Huang, Shuangliang Zhao, Zhuan Zhang
I₂- and Ru₃(CO)₁₂/I₂-catalyzed protocols enable tunable, regioselective multisite thiolation of 2-pyridones with disulfides, allowing access to C3-, C5-, C3,C5-, and C3,C6-thiolated products.
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