RSC - RSC Adv.-Chemical Biology and Medicinal latest articles

Design, synthesis and biological evaluation of tacrine-sulphonamide hybrids as a potent acetylcholinesterase inhibitor

RSC Adv., 2026, 16,18061-18072
DOI: 10.1039/D6RA00900J, Paper

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Mangari Madhusudhan Reddy, Eeda Koti Reddy, Abhithaj J, Radul R. Dev, V. S. Nagarajesh Kadambari, Shaik Anwar
Compound 6j, a methyl‑substituted tacrine‑sulfonamide piperazine derivative, showed potent AChE inhibition with strong CAS/PAS binding (glide score −9.18, binding energy −97.92). In vitro IC₅₀ was 7.40 nM, making it a promising lead for Alzheimer’s therapy.
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Bio-degradable electrospun nanofibers encompassing dioxidovanadium benzimidazole compounds as potential drug delivery systems for diabetes mellitus

RSC Adv., 2026, 16,27994-28003
DOI: 10.1039/D6RA01655C, Paper

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Sanam Maikoo, Mongezi Majebe, Andile Khathi, Allen Mambanda, Bongeka Mshengu, Lindokuhle Patience Mabuza, Phikelelani Ngubane, Irvin Noel Booysen
Respective vanadium compounds with bidentate benzimidazole chelators were incorporated into biodegradable electrospun nanofibers (ENFs). The resultant nanocomposites illustrated time-dependent drug release profiles and glucose-lowering activities.
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Berberis turcomanica berries: an integrated evaluation of antioxidant, enzyme inhibitory, and antimicrobial activities, phytochemical profile and in silico analysis

RSC Adv., 2026, 16,30814-30832
DOI: 10.1039/D6RA02922A, Paper

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Serdar Korpayev, Emre Can Buluz, Jasmina Glamočlija, Neda Popović, Uroš Gašić, Dejan Stojković, Hemra Hamrayev, Mirap Agamuradov, Savaş Kaya, Enver Saka, Gökhan Zengin
These findings constitute the first comprehensive pharmacological and chemical study of B. turcmanica berries and highlight their promise as a versatile natural agent for both pharmaceutical and nutraceutical applications.
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Synthesis, characterisation and antibacterial activity of flavone-based Sn(IV) and Sb(III) complexes

RSC Adv., 2026, 16,30649-30661
DOI: 10.1039/D6RA04588J, Paper

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Jakia Parbin Sultana, Sunali Saikia, Partha Pratim Saharia, Namisha Das, Debasish Borbora, Tridib K. Goswami
Sn(IV) and Sb(III) flavonoid complexes display significant in vitro antibacterial activity, especially against the Gram-positive S. aureus (MTCC 96) probably via rupture of cell membrane as evident from scanning electron microscopic images.
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Role of polymeric nanocomposite for tissue engineering applications

RSC Adv., 2026, 16,30889-30915
DOI: 10.1039/D6RA01646D, Review Article

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Shivakumar Naik, Uma Palanikumar, Amgoth Ramesh, Udayakumar D, B. C. Revanasiddappa, Harishkumar Madhyastha, Akhil Nair, Wilona Loren Lobo, Pavithra Pradeep Prabhu
Polymeric nanocomposites have become revolutionary biomaterials for tissue engineering due to their unparalleled tunability by combining the design flexibility of polymeric matrices and functional properties of nano-fillers.
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Chitosan-confined selenium–silver nanohybrids enable redox-modulated mitochondrial apoptosis and survival improvement in experimental hepatocellular carcinoma

RSC Adv., 2026, 16,30833-30858
DOI: 10.1039/D6RA01968D, Paper

Open Access

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Youssef M. Hassan, Doaa A. Elawady, Ahmed Wanas, Hala El-Tantawi, Dalia M. El-Husseini
Polymer-confined multi-metal nanostructures offer a strategy to modulate tumor redox balance with improved selectivity.
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Therapeutic exosomes in cancer: efficacy and safety perspectives

RSC Adv., 2026, 16,30633-30648
DOI: 10.1039/D6RA00373G, Review Article

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Rajib Dhar, Ling Shing Wong, Vetriselvan Subramaniyan
Therapeutic exosomes are cutting-edge, cell-free, promising tools for cancer treatment due to their biocompatibility, targeting ability, and cargo delivery potential. This review discusses current evidence on their efficacy, safety, challenges, and clinical prospects.
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α-Alkylated α-amino acids reduce the aggregation of unfolded peptides

RSC Adv., 2026, 16,30200-30204
DOI: 10.1039/D6RA03257E, Paper

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Haoliang Zheng, Robert W. Newberry
α-Ethylated α-amino acids reduce peptide aggregation by blocking β-sheet formation, whereas α-methylated α-amino acids reduce aggregation by increasing peptide helicity.
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Pharmacophore-targeted fluorescence sensing of ibrutinib via Michael addition-induced electron transfer on thiol-functionalized carbon dots

RSC Adv., 2026, 16,30676-30686
DOI: 10.1039/D6RA02905A, Paper

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Mohamed N. Goda, Laila S. Alqarni, Faisal K. Algethami, Hossieny Ibrahim, Mohamed M. El-Wekil, Ramadan Ali, Suliman A. Almahmoud, Al-Montaser Bellah H. Ali
Thiol-functionalized carbon dots enable selective fluorescence sensing of ibrutinib through Michael addition-induced electron transfer, offering a simple platform for serum analysis in chronic lymphocytic leukemia.
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Structure–biological activity relationships in a zinc(II) pyrazole halide complex [ZnCl2(η1-4BrPz)2] via noncovalent interactions, molecular docking, and antimicrobial studies

RSC Adv., 2026, 16,30614-30632
DOI: 10.1039/D6RA01123C, Paper

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Houyem Khlifi, Naoufel Ben Hamadi, Noureddine Mhadhbi, Antonio Sánchez-Coronilla, Khaled Hamden, Ahlem Guesmi, Lotfi Khezami, Hajir Wahbi, Houcine Naïli
The zinc(II) pyrazole complex [ZnCl₂(η¹-4BrPz)₂] was synthesized and characterized. DFT, ELF, NCI, and Hirshfeld analyses show that halogen contacts, π-stacking, and H-bonding stabilize the crystal. Antibacterial assays reveal promising activity.
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Triazine-based corrosion inhibitors: synthesis, significance, and emerging perspectives

RSC Adv., 2026, 16,30281-30309
DOI: 10.1039/D5RA09707J, Review Article

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Ihab Shawish, Hessa H. Al-Rasheed, Assem Barakat, Hassan H. Hammud, Ayman El-Faham
Triazine based compounds are promising corrosion inhibitors due to their nitrogen rich structure, which promotes strong adsorption on metal surface.
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Novel benzothiazole-indole acetamides as potential anticancer agents: synthesis, biological evaluation, and in silico studies

RSC Adv., 2026, 16,30111-30123
DOI: 10.1039/D5RA08263C, Paper

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Nazanin Motamedi Shakib, Manica Negahdaripour, Mohammad Hosein Sayahi, Navid Dastyafteh, Zahra Dehghani, Mina Emami, Sajedeh Safapoor, Younes Ghasemi, Seyedeh Niloufar Ghafouri, Abbas Ghahramani, Mohammad Reza Mohajeri-Tehrani, Bagher Larijani, Mohammad Mahdavi, Sara Ranjbar
Benzothiazole-indole hybrids were synthesized and evaluated for antiproliferative effects. The most potent derivative was subjected to cell cycle and apoptosis investigations. Compound 9d is suggested as a promising anticancer agent.
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An injectable hyaluronic acid hydrogel integrating Fe(III)-coordination and polymyxin B grafts for accelerated healing of infected diabetic wounds

RSC Adv., 2026, 16,30145-30157
DOI: 10.1039/D6RA03137D, Paper

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Mingchen Zhang, Wei Zhao, Yang Zhou, Ruiting Shen, Yiqiong Sun, Lei Jiang, Jiantao Zhang
HA-B@Fe hydrogel combines covalent polymyxin B grafting and Fe³⁺ coordination for self-healing and contact-killing, promoting infected diabetic wound repair in rats.
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Design, synthesis and response surface optimization of a high-performance LaFeO3/Mg–Al layered double hydroxide/chitosan ternary nanocomposite as a pH-responsive carrier for controlled celecoxib release: experimental evaluation and kinetic modeling

RSC Adv., 2026, 16,30477-30496
DOI: 10.1039/D5RA09708H, Paper

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Samira Moradi Kozaraji, Seyed Mahdi Mousavi, Moslem Setoodehkhah
In this study, an advanced ternary nanocomposite, LaFeO₃/Mg–Al LDH/chitosan, was meticulously designed and synthesized as a pH-responsive controlled drug delivery system for the anti-inflammatory drug celecoxib.
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Unveiling the antioxidant and anti-epileptic potential of Castanea sativa against pentylenetetrazole in mice: a comparative LC-MS analysis of two ethanol-based fractions

RSC Adv., 2026, 16,30355-30368
DOI: 10.1039/D6RA02693A, Paper

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Abeer Salama, Rasha M. M. Mohasib, Hagar H. Mourad, Nesrine M. Hegazi, Tarik A. Mohamed, Mohamed-Elamir F. Hegazy
Comprehensive metabolome profiling of Castanea sativa fruits, and their antioxidant and neuroprotective potential.
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Synthesis and structure–activity relationships of indole-3-butyric acid-based hydrazones: predicting their antibacterial and antioxidant potential through integrated experimental, molecular docking and DFT studies

RSC Adv., 2026, 16,30408-30433
DOI: 10.1039/D6RA01763K, Paper

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Mudasara Azam, Talha Mashhood, Shehar Bano, Muhammad Ibrahim, Sehar Nadeem, Humaira Zulfiqar, Nora Hamad Al-Shaalan, Sarah Alharthi, Mohammed A. Amin, Muhammad Usman Khan
The synthesis and DFT-guided analysis of indole-3-butyric acid hydrazones reveal DHIBH as a potent antibacterial and antioxidant, with docking, NLO, and ADMET studies supporting its multifunctional potential.
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Unlocking the antidiabetic potential of novel pyrazole-triazole hybrids through synthesis, dual α-amylase/α-glucosidase inhibition, multiscale biological evaluation, and molecular dynamics studies

RSC Adv., 2026, 16,30070-30092
DOI: 10.1039/D6RA02783K, Paper

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Mariam M. Fakhry, Mahmoud S. Elkotamy, Mohamed K. Elgohary, Mahmoud Abdelrahman Alkabbani, Mayada H. Mohamed, Abdulrahman A. Almehizia, Ahmed M. Naglah, Morkoss M. Fakhry, Mohamed Fares, Hatem A. Abdel-Aziz, Jalloul Bouajila
This study aimed to design potent antidiabetic agents based on a pyrazole-linked carbohydrazide scaffold.
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Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity

RSC Adv., 2026, 16,30052-30069
DOI: 10.1039/D6RA03557D, Paper

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Basima A. A. Saleem, Ashraf A. Qurtam, Abdelrahman R. Shalabi, Mohammed Al-zharani, Kasim Sakran Abass, Stefan Bräse, Ghallab Alotaibi, Abdullah Alkhammash
A novel series of pyrazole/thiazole chalcone hybrids (9a–o) was designed, synthesized, and evaluated as dual tubulin/COX-2 inhibitors with anticancer activity.
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Native mass spectrometry reveals DltA catalysis, DltC loading, and inhibition in the D-alanylation pathway

RSC Adv., 2026, 16,29834-29843
DOI: 10.1039/D6RA04213A, Paper

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Yi Wang, Hannah Squires, Marian Aba Addo, Jospeh P. Gerdt, Tarick J. El-Baba, R. Craig MacLean, Carol V. Robinson, Jani R. Bolla
Gram-positive bacteria protect their cell envelope by D-alanylating lipoteichoic acid (LTA). DltA activates D-alanine and loads it onto holo-DltC, which works with DltB, DltX and DltD to transfer D-alanine onto LTA.
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Electrospun collagen/hyaluronic acid dressing co-loaded with EGF and bFGF for enhanced diabetic wound healing

RSC Adv., 2026, 16,29807-29822
DOI: 10.1039/D5RA09378C, Paper

Open Access

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Liang Wu, Wei Wang, Linxinyi Chen, Duohui Li, Yijun Ke, Yanghui Xu, Bo Zhu, Fangqi Hu, Lishang Dai, Xiwu Shi
An electrospun collagen I/hyaluronic acid dressing co-loaded with EGF and bFGF promotes diabetic wound healing by stabilizing growth factors and accelerating tissue regeneration.
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Bridging the gap in Alzheimer's therapy: strategic design and SAR evolution of coumarin-based hybrids as potent MTDLs

RSC Adv., 2026, 16,29631-29660
DOI: 10.1039/D6RA03862J, Review Article

Open Access

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Omar K. El-Mokaddem, Ghada F. Elmasry, Walaa R. Mahmoud, Lina M. A. Abdel Ghany
Due to their multitargeting potential, coumarin-based hybrid molecules represent a new and valuable drug development strategy for the treatment of Alzheimer's disease (AD).
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Engineering matrix-embedded dual-drug eluting biodegradable surgical sutures for prophylaxis against surgical site infections

RSC Adv., 2026, 16,29478-29489
DOI: 10.1039/D6RA01817C, Paper

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Garba Mohammed Khalid, Neel Anil Chaudhary, Nura Hassan, Lubabah Rahman, Shahnaz Kashif, Gunjan V. Jahakar, Mouhamad Khoder
This work engineered biodegradable drug-eluting sutures via solvent-free hot-melt extrusion, enabling immediate and sustained levofloxacin and ibuprofen release to prevent surgical site infections while controlling inflammation.
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Synthesis, photophysical, computational, and cytotoxicity evaluation of carborane-appended phenylene and triazine trimers: elucidating the role of the central core

RSC Adv., 2026, 16,29733-29750
DOI: 10.1039/D6RA04231G, Paper

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Simran Pattnaik, Anwesha Pradhan, Laxmipriya Nayak, Subhadeep Acharya, Supriya Routray, Subhasri Dan, Soumya Ranjan Jena, Kshatresh Dutta Dubey, Luna Samanta, Rashmirekha Satapathy
Four ortho-carborane symmetrical trimers were synthesized and evaluated. The triazine-cored derivative Tz-9-CB selectively kills MDA-MB-231 TNBC cells (IC₅₀ = 6 µM, SI = 13 vs NIH/3T3) by inducing caspase-3-mediated apoptosis.
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Potent and selective α-glucosidase inhibition by coumarin–triazole conjugates: design, in vivo evaluation, and computational insights

RSC Adv., 2026, 16,29844-29866
DOI: 10.1039/D6RA01115B, Paper

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Mahdis Sadeghi Moghadam, Bahareh Bayati, Fariba Peytam, Maryam Norouzbahari, Hayrettin Ozan Gülcan, Somayeh Mojtabavi, Fahimeh Ghasemi, Seyed Esmaeil Sadat-Ebrahimi, Maliheh Barazandeh Tehrani, Vahid Sheibani, Loghman Firoozpour, Alireza Foroumadi
Compound 12q emerged as the most potent inhibitor (IC₅₀ = 1.0 µM) and showed high selectivity toward α-glucosidase over α-amylase. The in silico studies further confirmed the activity. In vivo studies demonstrated that 12q outperformed acarbose.
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Design, synthesis, and biological evaluation of novel imidazole–morpholinone hybrids as broad-spectrum antimicrobial agents: molecular docking, DFT, and ADMET studies

RSC Adv., 2026, 16,29867-29883
DOI: 10.1039/D6RA03352K, Paper

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Amrish J. Dave, Sweta S. Joshi, Jay B. Maheta, Yogesh O. Bhola, Jatin Upadhyay
Five-step convergent synthesis of imidazole–morpholinone hybrids (10a–e) via Suzuki–Miyaura coupling. Lead compound 10c demonstrates potent broad-spectrum antimicrobial activity through DNA gyrase inhibition with drug-like pharmacokinetic properties.
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A mechanically compliant MnO2–MXene–GelMA cardiac patch for modulating the post-infarction microelectrical environment and alleviating oxidative stress

RSC Adv., 2026, 16,29350-29360
DOI: 10.1039/D6RA02208A, Paper

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Meng Han, Hang Jin, Jinhui Zhang, Changrui Zhang, Weihu Yang, Daoheng Sun, Wenhua Huang
A 3D-printable MnO₂–MXene–GelMA cardiac patch with mechanical compliance, electrical coupling, and ROS scavenging for post-infarction microelectrical modulating and oxidative stress alleviation.
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Chemical epigenetic modification uncovers new isocoumarins from the endophyte Dothideomycetes sp. BMC-101

RSC Adv., 2026, 16,29240-29248
DOI: 10.1039/D6RA02544G, Paper

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Yajuan Cong, Haotian Wang, Hong Wang, Jing Jiang, Lanying Li, Runyu Wu, Yixuan Zhang, Qiang Huo, Meilin Zhu
Four isocoumarins, including two enantiomer pairs [(±)-dothideomarins A (1a/1b) and B (2a/2b)] and two analogs C and D (3 and 4), were isolated from endophytic fungus Dothideomycetes sp. BMC-101 via OSMAC & MS/MS molecular networking.
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Magnorolins A–L: sesquiterpenoids with diverse skeletons from the fruits of Magnolia grandiflora and their cytotoxic and anti-inflammatory activities

RSC Adv., 2026, 16,29012-29024
DOI: 10.1039/D6RA02737G, Paper

Open Access

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Qiu-Ye Zhao, Shi-Huan Yin, Xin-Ying Wang, Lu Sai, Lin-Fen Ding, Xing-De Wu
Twelve new sesquiterpenoids with diverse carbon skeleton, magnorolins A–L (1–3, 5–12, and 15), and four known analogues (4, 13, 14, and 16) were isolated from the fruits of Magnolia grandiflora.
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From biomass to bioactivity: Butea monosperma bark-derived carbon quantum dots for benzopyran synthesis and their in silico studies

RSC Adv., 2026, 16,28987-29011
DOI: 10.1039/D6RA02823C, Paper

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Sunita Teli, Shivani Soni, Nisarg Rana, Anu Manhas, Shikha Agarwal
A green synthetic protocol for the synthesis of benzopyrans has been developed using biomass-derived CQDs obtained from Butea monosperma bark. A diverse library of 17 benzopyrans was synthesized in high yields within 10–35 min at RT.
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A novel strategy for the photothermal treatment and electroencephalogram monitoring of in situ glioma

RSC Adv., 2026, 16,28955-28965
DOI: 10.1039/D6RA00499G, Paper

Open Access

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Haoyang Zhang, Ke Shi, Wenxuan Zhang, Xue Chen, Xi Wang, Yan Zhao, Hengyuan Pang, Xi Chen, Jianjiao Wang
An integrated PTT-EEG system based on micro-pyramid PPy films, combining an NIR-mediated photothermal therapy and intraoperative electroencephalogram monitoring, was developed for efficient, precise, and safe glioma treatment.
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Retraction: Molecular docking and in vivo/in vitro studies of a novel thiadiazole Schiff base as a hepatoprotective drug against angiogenesis induced by breast cancer

RSC Adv., 2026, 16,29153-29153
DOI: 10.1039/D6RA90056A, Retraction

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Norah F. Alqahtani, Mohammad Y. Alfaifi, Ali Shati A, Serag Eldin I. Elbehairi, Abdulrahman M. Saleh, Ebtesam S. Kotb, Waleed M. Serag, Reda F. M. Elshaarawy, Heba W. Alhamdi, Yasser A. Hassan
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Total synthesis of natural products facilitated by prins reaction: a review

RSC Adv., 2026, 16,28777-28826
DOI: 10.1039/D5RA09257D, Review Article

Open Access

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Samna Sohail, Samreen Gul Khan, Ameer Fawad Zahoor, Rabia Ashraf, Kulsoom Ghulam Ali, Bushra Parveen, Asim Mansha, Arif Mermer, Aijaz Rasool Chaudhry, Ahmad Irfan
The Prins reaction is a valuable synthetic strategy that enables C–C bond formation, leading to the construction of key core structures in natural products such as tetrahydropyrans, dihydropyrans, and spirocyclic ethers.
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Synthesis and characterization of bevacizumab-functionalized nanoliposomes loaded with regorafenib and fluorescent carbon dots for triple-negative breast cancer theranostics

RSC Adv., 2026, 16,28516-28525
DOI: 10.1039/D6RA03364D, Paper

Open Access

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Armita Aryanmanesh, Abolghasem Abbasi Kajani
A novel theranostic nanoplatform based on bevacizumab functionalized nanoliposomes incorporated with carbon dots for the targeted and controlled delivery of regorafenib and fluorescence imaging of triple negative breast cancer cells.
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Data-driven design and screening of novel Klebsiella pneumoniae carbapenemase-2 β-lactamase inhibitors using a generative CLM

RSC Adv., 2026, 16,28845-28856
DOI: 10.1039/D6RA02379G, Paper

Open Access

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Syeda Sumayya Tariq, Muhammad Salman Haleem, Reaz Uddin
Using generative chemical language modeling (CLM) for the design and discovery of novel KPC-2 Inhibitors targeting Klebsiella pneumonia.
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A Natural product-based composite nanozyme synergistically induces ferroptosis for lung cancer therapy

RSC Adv., 2026, 16,28583-28591
DOI: 10.1039/D6RA00383D, Paper

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Yishun Jin, Chen Huang, Zhenbo Geng, Huang Li, Huiqing Ge, Pengfei Wang, Chaojun Dai, Jun Li, Xiaohua Yan, Chen Li, Yan Zheng
The treatment of lung cancer remains a significant clinical challenge.
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Deep learning mechanism and its application in biomacromolecules

RSC Adv., 2026, 16,27008-27020
DOI: 10.1039/D6RA00550K, Review Article

Open Access

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Hairui Li, Guocheng Zhang, Bin Yan, Zaihang Ye, Xudong Zhen, Yang Liu
The incorporation of AI-driven predictive and generative technologies into the design cycle presents a major leap in advanced peptide-based biomacromolecule and biomaterial engineering, transforming both biology and materials science.
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Oxovanadium(IV/V) lawsone-based complexes: synthesis, characterization, DFT studies, and multifunctional biological activities

RSC Adv., 2026, 16,28376-28394
DOI: 10.1039/D6RA02275H, Paper

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Islam M. Elnabky, Mohamed M. Aboelnga, Heba A. Sahyon, Ahmed M. El-Hendawy, Shadia A. Elsayed
Three oxovanadium(IV/V) complexes with lawsone (HLw) were synthesized, including [VO(Lw)₂(H₂O)]·H₂O (1), [VO(Lw)₂Cl]·H₂O (2), and [VO₂(Lw)(bpy)] (3), and investigated for their structural features and biological potential.
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From molecular design to antiepileptic evaluation: sulfonamide–pyrazole derivatives as promising neuroactive agents

RSC Adv., 2026, 16,28667-28684
DOI: 10.1039/D6RA01165A, Paper

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Mohamed K. Elgohary, Mahmoud Abdelrahman Alkabbani, Aya Mohamed Ahmed Ibrahim, Ahmed Elsonbaty, Abdelhameed Abubakr, Mayada H. Mohamed, Abdulrahman A. Almehizia, Ahmed M. Naglah, Mohamed Fares, Hatem A. Abdel-Aziz
Neuroinflammation, oxidative stress, and glutamate-mediated excitotoxicity are central pathological mechanisms underlying epileptogenesis and seizure propagation.
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Electrospun Zn-cobimetinib-levofloxacin-PVA/PVP nanofibers for skin-targeted anticancer and antimicrobial applications

RSC Adv., 2026, 16,28254-28264
DOI: 10.1039/D6RA03437C, Paper

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Zainb A. Talib, Ahmed kareem obaid Aldulaimi, Farag M. A. Altalbawy, Jameel M. A. Sulaiman, Rafid Jihad Albadr, Waam Mohammed taher, Nasr Saadoun Abd, Hiba Mushtaq, Hadil Faris Alotaibi, Adama Faye
Electrospun Zn-coordinated PVA/PVP nanofibers simultaneously suppress skin cancer cells and microbial pathogens (bacterial and fungi), providing a multifunctional platform for therapeutic wound dressings.
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UPLC-MS/MS analysis and bioactivity comparison of wild and cultivated Taihangia rupestris leaves: antioxidant and α-glucosidase inhibitory activities with active compound screening

RSC Adv., 2026, 16,28230-28242
DOI: 10.1039/D6RA00256K, Paper

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Jin-tuo Yin, De-mao Wang, Xue-chun Wu, Juan Lu, Zheng-ming Qian, De-qiang Li, Rui Feng
Taihangia rupestris Yu & Li (T. rupestris) was a nationally protected plant and its active compounds exhibit antidiabetic potential, but systematic phytochemical and pharmacological investigations remain limited.
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Spontaneous self-assembly of mangiferin in an aqueous medium into vesicles for anticancer drug encapsulation and antibacterial applications

RSC Adv., 2026, 16,28103-28112
DOI: 10.1039/D6RA01279E, Paper

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Sukhendu Kar, Soumen Patra, Wachirasak Thaisaeng, Chatphorn Theppitak, Nopporn Thasana, Braja Gopal Bag
Mangiferin spontaneously self-assembles into stable vesicles in aqueous solutions. These nanocarriers encapsulate anticancer drugs (doxorubicin/curcumin) and display significantly enhanced antibacterial activities when loaded with curcumin.
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A rhein-integrated hydrogel dressing with antibacterial, antioxidant and pH-responsive colorimetric properties

RSC Adv., 2026, 16,28092-28102
DOI: 10.1039/D6RA03047E, Paper

Open Access

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Miaoshen Kou, Deng Wang, Jiawei Zhang, Fangzheng Yu, Yang Yuan, Chen Wang, Jiale He, Zheng Zhao, Yichao Liu
The novel SF/HA/Rhe hydrogel exhibits antibacterial, antioxidant and pH-responsive colorimetric functions and has potential application as multifunctional wound dressing for visual monitoring.
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A QbD optimization of a pH-responsive Eudragit S100–chitosan nanoformulation for the co-delivery of pentoxifylline and simvastatin in colorectal cancer therapy

RSC Adv., 2026, 16,27847-27877
DOI: 10.1039/D6RA02003H, Paper

Open Access

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Samar M. Mahgoub, Seham M. Hamed, Ahmed A. Allam, Doaa R. I. Abdel-Gawad, Ahmed G. Soliman, Khaled Metwally, Rehab Mahmoud
Colorectal cancer (CRC) presents a significant global health challenge, where the efficacy of conventional treatments is often hampered by systemic toxicity, poor bioavailability, and drug resistance.
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Chalcone–sulfonate ester derivatives as dual urease and α-amylase inhibitors: synthesis, biological evaluation and integrated computational studies

RSC Adv., 2026, 16,27915-27936
DOI: 10.1039/D6RA02588A, Paper

Open Access

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Zobia Noreen, Amina Sadiq, Nafeesa Naeem, Usama Raza, Ishtiaq Ahmed, Samar Y. Al Nami, Aisha Hossan, Magdi E. A. Zaki, Ehsan Ullah Mughal
A series of chalcone–sulfonate ester derivatives (1–7) were synthesized and evaluated for their potential inhibitory activity against urease and α-amylase enzymes.
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Problems in the use of chemical and functional nomenclatures for steroids in human physiology, biology and pharmacology

RSC Adv., 2026, 16,27678-27691
DOI: 10.1039/D5RA08275G, Review Article

Open Access

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John W. Honour
Steroid compounds are important messengers in the human body that can be described using multiple nomenclature systems, each reflecting a different perspective on structure or function.
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Development of new quinoline-triazole based hybrids: synthesis, nano-encapsulation, DFT calculations, and evaluation of antidiabetic and antioxidant activity

RSC Adv., 2026, 16,27884-27905
DOI: 10.1039/D6RA01266C, Paper

Open Access

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Fatma M. Elhalmoushy, Mohamed N. Abd Al Moaty, Alaa S. Hegazy, Saied M. Soliman, Mazen Sherif, Doaa A. Ghareeb, Mohamed Hagar, Manar Ahmed Fouad
Newly synthesized quinoline-triazole hybrids were robustly synthesized, chitosan nano-encapsulated, thoroughly studied and effectively evaluated as antidiabetic and antioxidant agents.
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D-Leucine modified Sansalvamide A analogs: photo-induced synthesis, target prediction, and antitumor potential study

RSC Adv., 2026, 16,27786-27794
DOI: 10.1039/D6RA02497A, Paper

Open Access

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Yujun Bao, Fujing Guan, Fengmei Shi, Su Wang, Liguo Wei, Pengfei Li, Zhanjiang Pei, Lishuang Zhao, Chuncheng Hao
Five Sansalvamide A analogs with isoindolinone were synthesized via photoinduced SET cyclization. The multi-D-leucine-modified Compound 5 binds BCL2 with high affinity and has the potential to induce tumor apoptosis by reducing MMP.
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Discovery of triazole-tethered glycinate and propanoate derivatives bearing a thiolactone moiety as quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis, biological evaluation, and biofilm inhibition

RSC Adv., 2026, 16,27977-27993
DOI: 10.1039/D6RA00717A, Paper

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Kosana Sai Chaitanya, Tsz Tin Yu, Hrushikesh Chaudhari, Nidhi Orenkonday, Pranali Vijaykumar Kuthe, Naresh Kumar, Ruchi Jain Dey, Sankaranarayanan Murugesan, Kondapalli Venkata Gowri Chandra Sekhar
Quorum sensing regulates biofilm, virulence and resistance in bacteria. Thiolactone-based 1,2,3-triazole hybrids were synthesized as LasR-targeting inhibitors against Pseudomonas aeruginosa. Compounds 10o and 11b showed strong biofilm inhibition.
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Gingerol-loaded hollow manganese dioxide nanoparticles attenuate intervertebral disc oxidative stress

RSC Adv., 2026, 16,25447-25458
DOI: 10.1039/D6RA00597G, Paper

Open Access

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Xu Liu, Bolin Lu, Yunqi Zhou, Chengdong Zhang, Feng Shi, Gang Feng, Xuwei Luo, Dongqin Xiao
Schematic illustration of H@G synthesis and its protective mechanism in nucleus pulposus cells: it scavenges ROS, improves mitochondrial function, restores redox homeostasis, and repairs ECM.
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Advancements in the manufacturing routes for the synthesis of marketed PARP inhibitors

RSC Adv., 2026, 16,27593-27609
DOI: 10.1039/D6RA03016E, Review Article

Open Access

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Dhurgam Rani, Magdalena Plebanski, Tanmay Chatterjee
This article reviews the available literature on manufacturing routes to access the marketed PARP inhibitors, such as olaparib, rucaparib, niraparib, talazoparib, fuzuloparib, pamiparib and senaparib, since 2017.
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A layered double hydroxide nanocarrier enables YM155 delivery-induced PANoptosis and immunogenic activation in hepatocellular carcinoma

RSC Adv., 2026, 16,27560-27578
DOI: 10.1039/D6RA01379A, Paper

Open Access

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Jie Gong, Xianxing Wang, Jiali Yang, Li Tang, Lei Cai, Huaizhi Wang
LDH-YM155 enhances YM155 delivery to suppress Survivin, induce PANoptosis and ICD-associated immune activation, and inhibit hepatocellular carcinoma growth.
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Facile synthesis of (4-phenylthiophen-2-yl)methyl 1-naphthoates via Suzuki–Miyaura cross-coupling: anti-seizure evaluation through molecular docking, EEG analysis, and ADMET profiling

RSC Adv., 2026, 16,27547-27559
DOI: 10.1039/D6RA02094A, Paper

Open Access

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Nayab Mohsin, Nasir Rasool, Aqsa Kanwal, Khaled Ahmed Saghir, Imran Imran, Farhan Siddique, Sumaira Nadeem, Muhammad Imran
A series of novel thiophene naphthoates is synthesized via Suzuki coupling and evaluated for antiepileptic potential, supported by docking studies, EEG analysis, and ADMET studies.
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Magnetite hybrid hydrogel of xanthan gum and poly(N-hydroxyethyl acrylamide): a cytocompatible vehicle for sustained oral dual delivery of 5-fluorouracil and curcumin

RSC Adv., 2026, 16,27579-27592
DOI: 10.1039/D6RA01832G, Paper

Open Access

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Ngeleja S. Hamis, Amos Luanda, John J. Makangara
Developed magnetite hybrid hydrogel enables pH-responsive oral co-delivery of 5-fluorouracil and curcumin, with sustained release, enhanced drug loading and selective cytotoxicity against cancer cells.
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The protein corona at the nano-bio interface: the need for standardized methodology and opportunities for neurodegenerative disease intervention

RSC Adv., 2026, 16,27424-27452
DOI: 10.1039/D6RA01255H, Review Article

Open Access

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Getasew Shitaye, Martina Dragone, Zewdie Mekonnen, Awet Ghebretinsae Tewelde, Maria Della Valle, Gaetano Caputo, Mohammadhossein Mosalaeizadehyazd, Gianluca D'Abrosca, Luigi Russo, Roberto Fattorusso, Carla Isernia, Gaetano Malgieri
This review analyzes the protein corona at the nano-bio interface and proposes a standardized methodological framework. We explore how nanoparticles can accelerate or inhibit neurodegenerative pathology, turning the PC into a functional tool.
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Multicomponent synthesis of 2H-chromene-fused-thiazolo-triazole derivatives via cascade Michael addition/cyclization reaction: anticancer, antibacterial and computational evaluations

RSC Adv., 2026, 16,27374-27396
DOI: 10.1039/D6RA03687B, Paper

Open Access

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Barsha Samanta, Tapaswini Pati, Ananya Dash, Bhabani Shankar Panda, Eeshara Naik, Seetaram Mohapatra, Chita Ranjan Sahoo, Pradeep Kumar Naik
An efficient synthesis of 2H-chromene-fused thiazolo-triazoles via a multicomponent cascade C–N/C–S bond-forming strategy is reported. Biological evaluation and computational studies identify potent dual anticancer and antibacterial candidates.
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NanoBRET-based detection of ligand–receptor interactions at the neuropeptide FF receptor 1

RSC Adv., 2026, 16,27138-27145
DOI: 10.1039/D6RA01350C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Hannah Lentschat, Annette G. Beck-Sickinger
Characterization of ligand binding at the neuropeptide FF receptor 1 (NPFFR1) through a nanoBRET-based assay.
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The cocrystals of isorhamnetin and isoliquiritigenin with 4,4′-bipyridine: system characterization, stability, dissolution and anticancer activity

RSC Adv., 2026, 16,27212-27222
DOI: 10.1039/D6RA01981A, Paper

Open Access

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Yu Liu, Jian Lei, Ting Li, Aiyu Zhong, Zihan Zhu, Junxiao Lu, Zhipeng Wang, Panpan Zhao, Zhigang Wu
Two novel cocrystals including isorhamnetin-4,4′-bipyridine and isoliquiritigenin-4,4′-bipyridine were firstly successfully prepared and they possessed improved anticancer efficacy.
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Curcumin derivatives with 1,5-diaryl-3-oxo-1,4-pentadiene: novel dual-function lead compounds showing anticancer and MDR reversal effects

RSC Adv., 2026, 16,27194-27201
DOI: 10.1039/D6RA02187E, Paper

Open Access

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Qinglong Wang, Xiaofan Zhang, Jiacheng Yuan, Yan Ren, Huanhuan Yan, Jufeng Sun
Six 1,5-diaryl-3-oxo-1,4-pentadiene libraries (Curcumin derivatives) were synthesized, and their anticancer, MDR reversal activity and cellular uptake were determined.
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An approach for the systematic profiling of drug-induced remodeling of RNA–RBP (RNA-binding protein) interactions

RSC Adv., 2026, 16,27057-27068
DOI: 10.1039/D6RA00871B, Paper

Open Access

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Yajie Jiao, Jinguo Zhao, Bin Fu, Peiying Dong, Xiaohong Qian, Tong Liu, Weijie Qin
An integrated approach combining biotinylated furocoumarin probe-mediated RPC enrichment with quantitative proteomics is presented for the profile drug-induced remodeling of RNA–RBP interactions.
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Combinatorial and rational synthesis of complex, base-modified aptamer libraries on microarrays

RSC Adv., 2026, 16,26976-26987
DOI: 10.1039/D6RA01942K, Paper

Open Access

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Erika Schaudy, Jory Lietard
Complementing photolithographic microarray synthesis with nucleobase-modified DNA nucleotides yields large oligonucleotide libraries and allows for full control in combining type and position of modifications along any sequence.
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Design, synthesis, and biological evaluation of multifunctional dispiro chromeno-indenoquinoxaline hybrids as dual anticancer and antibacterial agents with metal-ion sensing ability

RSC Adv., 2026, 16,26805-26831
DOI: 10.1039/D6RA01808D, Paper

Open Access

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Kamalika Prusty, S. S. S. S. Sudha Ambadipudi, Suhasini Mohapatra, Tankadhara Behera, Bhabani Shankar Panda, Gopinatha Panigrahi, Sabita Nayak, Seetaram Mohapatra, Akankhya Mohanty, Jyotiprabha Rout, Chita Ranjan Sahoo, V. Lakhsma Nayak
Aqueous 1,3-dipolar cycloaddition of indenoquinoxaline nitrones with 2H-chromenes affords dispiro chromeno-indenoquinoxaline hybrids with anticancer, antibacterial, and selective Fe²⁺/Pd²⁺ fluorescence sensing properties.
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Synthesis and in silico insights of some tetrahydrobenzothienopyrimidine candidates as multi-target antimicrobial, antiproliferative, and antiviral agents

RSC Adv., 2026, 16,26909-26927
DOI: 10.1039/D6RA01842D, Paper

Open Access

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Amna S. Elgubbi, Selwan Hamed, Budur Nuwayji Alanazi, Hoda A. Ahmed, Sayed K. Ramadan
Fused tri- and tetracyclic tetrahydrobenzo[b]thiophenes were prepared. Tetracyclic derivatives showed potent antibacterial, antifungal, and antiviral activity; cyanomethyl was most active vs. HAdV-7 and SARS-CoV-2, followed by thiazolidinone.
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Antibacterial electrospun nanofibrous mats fabricated from polycaprolactone, gelatin and Synedrella nodiflora extract for biomedical applications

RSC Adv., 2026, 16,26320-26333
DOI: 10.1039/D6RA01137C, Paper

Open Access

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Amanullah, Mainul Islam, Md. Mustafizur Rahman, Md. Farhad Hossain
Electrospun PCL/gelatin nanofibers incorporating Synedrella nodiflora extract showed enhanced antibacterial activity, controlled release, and improved moisture management, making them promising candidates for wound healing applications.
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Encapsulation of the novel mPGES-1 inhibitor TG554 in acetalated dextran nanoparticles

RSC Adv., 2026, 16,26869-26879
DOI: 10.1039/D6RA01745B, Paper

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Franziska Adermann, Jana Ismail, Thorben Köhler, Lea C. Klepsch, Bärbel Beringer-Siemers, Carolin Kellner, Steffi Stumpf, David Pretzel, Lisa Jäpel, Ivo Nischang, Zehra Tuğçe Gür Maz, Philipp Dahlke, Hannes Engelbrecht, Paul M. Jordan, Antje Vollrath, Stephanie Schubert, Erden Banoglu, Oliver Werz, Ulrich S. Schubert
Optimized formulation of AcDex nanoparticles for the successful delivery of the novel anti-inflammatory drug TG554 to M1 macrophages.
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In silico design and binding mechanism of UBR1 E3 ligase recruiters

RSC Adv., 2026, 16,26659-26668
DOI: 10.1039/D5RA04908C, Paper

Open Access

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Miguel A. Maria-Solano, Raudah Lazim, Sun Choi
Virtual screening workflow for designing UBR1 E3 ligase recruiters.
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New phenylcyclopropane-carbohydrazide furan derivatives with potent anticancer activity and EGFR inhibitory potential

RSC Adv., 2026, 16,26273-26291
DOI: 10.1039/D5RA09654E, Paper

Open Access

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Suresh Patagani, Kolli Balakrishna, Mahadevappa Naganathappa, Dhilli Rao Gorja, Naresh Kumar Katari, Vani Madhuri Velavalapalli, Rambabu Gundla
Fifteen new phenylcyclopropane-carbohydrazide-containing furan derivatives are synthesised and thoroughly characterized using FT-IR, ¹H-NMR, ¹³C-NMR, and HRMS spectroscopy techniques in the search for new anticancer drugs.
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New fused tetracyclic ring systems: synthesis of 1-thia-4a,11,12-triazatetracenes via a multicomponent strategy, 2D-HMBC structural confirmation, and antimicrobial activity

RSC Adv., 2026, 16,25999-26011
DOI: 10.1039/D6RA03008D, Paper

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Reham E. Abdelwahab, Mostafa E. Salem, Mohammed Rashed Alsulami, Mona M. Soliman, Ismail A. Abdelhamid, Amr Mohamed Abdelmoniem, Faisal K. Algethami, Ahmed H. M. Elwahy
A novel multicomponent synthesis of tetracyclic 1-thia-4a,11,12-triazatetracenes exhibit promising antimicrobial activity, with compound 9a emerging as a potent broad-spectrum lead supported by molecular docking studies.
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Microinjection molded PLA/ZnO-TiO2 composites with in situ fibrillation: achieving mechanical matching cortical bone and enhanced osteoinduction

RSC Adv., 2026, 16,25503-25514
DOI: 10.1039/D5RA07812A, Paper

Open Access

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Yong Xiang, Wenhao Song, Hui Yang, He Cai, Yijun Li, Tao Hu
ZnO nanoparticles were anchored to fibrous TiO₂ substrates via hydrothermal deposition to minimize agglomeration. The incorporated ZnO markedly enhanced the bioactivity of the PLA-based devices, ultimately boosting their osteogenic capability.
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Development of an AQbD-guided sustainable RP-HPLC method for simultaneous quantification of saracatinib and rapamycin in lipid–polymer hybrid nanocarriers

RSC Adv., 2026, 16,26526-26545
DOI: 10.1039/D6RA01901C, Paper

Open Access

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Mohit Angolkar, Sharanya Paramshetti, Darshan Patil, Asha Spandana K. M., Riyaz Ali M. Osmani, H. V. Gangadharappa, Adel Al Fatease, Ali H. Alamri, Umme Hani
AQbD-guided sustainable RP-HPLC enables simultaneous quantification of saracatinib and rapamycin in lipid–polymer hybrid nanocarriers.
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Genipin-crosslinked CeO2-incorporating Janus patch for oral ulcer treatment

RSC Adv., 2026, 16,26546-26560
DOI: 10.1039/D6RA00275G, Paper

Open Access

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Han Sol Kim, Sujin Park, Shazid Md. Sharker, Sang-woo Lee, Ji Hyun Ryu
The genipin-crosslinked CeO₂-incorporated Janus patch provides a robust and localized therapeutic strategy for oral ulcers, offering a clinically relevant platform.
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Copper-hollow mesoporous polydopamine-polyacrylic acid nanoplatform enabling photoacoustic imaging-guided photothermal/chemodynamic therapy for osteosarcoma

RSC Adv., 2026, 16,26561-26571
DOI: 10.1039/D6RA01369D, Paper

Open Access

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Haoyu Sun, Zeping Liu, Bowen Chen, Yunkai Bao, Fenghua Li, Rui Gu, Zhenxin Wang
HMPDA-Cu@PAA nanozymes enable photoacoustic imaging (PAI)-guided CDT–PTT therapy via GSH-responsive Cu²⁺/Cu⁺ redox cycling in osteosarcoma.
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GO/APTES-mediated bifunctional CuFe2O4@GO-NH2-facilitated synthesis of pyrazolo-triazepine scaffolds as a potent post-prandial antidiabetic agent against dual α-amylase and α-glucosidase enzymes

RSC Adv., 2026, 16,26249-26272
DOI: 10.1039/D6RA00293E, Paper

Open Access

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Romica Jain, Ashok Kumar, Pratibha Sharma
CuFe₂O₄@GO-NH₂ driven synthesis and multidimensional analysis of pyrazolo-fused triazepine for antidiabetic potential.
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MRI tumor imaging by click chemistry using Gd(III)-DOTA-DBCO and Ac4ManNAz

RSC Adv., 2026, 16,26448-26451
DOI: 10.1039/D6RA02364A, Paper

Open Access

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Nobuhiko Ichiki, Hisao Saneyoshi, Hiroyuki Satoh, Atsushi Nanashima, Yan Xu
MRI tumor imaging by click chemistry.
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Synthesis, molecular modelling, and evaluation of new mono- and bis-isoxazolines as antibacterial agents: in vitro and in silico analysis

RSC Adv., 2026, 16,26399-26420
DOI: 10.1039/D5RA09902A, Paper

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Ali Altharawi, Bharath Kumar Chagaleti, Mubarak A. Alamri, Yassine Riadi, Taibah Aldakhil, Ait Itto Moulay Youssef, Ali Oubella, Reda A. Haggam
Novel mono- and bis-isoxazoline compounds were synthesized and showed strong antibacterial activity. Network pharmacology highlights key pathways involved, and supported by docking and molecular dynamics, confirming stable target binding.
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Comparative evaluation of donepezil-loaded polymeric and liposomal nanoparticles for Alzheimer's disease: biocompatibility, drug release kinetics, and cellular uptake study

RSC Adv., 2026, 16,26222-26237
DOI: 10.1039/D6RA00929H, Paper

Open Access

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Toros Torossian, Kawthar K. Abla, Jana Dakour, Sara Assi, Mia Karam, Rami Mhanna
Donepezil-loaded PCL/PVA nanoparticles and DPPC liposomes exhibited nanoscale dimensions and a safe profile. Polymeric nanoparticles exhibited greater cellular uptake, highlighting the influence of nanocarrier composition on cell-nanoparticle interactions.
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Design, synthesis, antimicrobial and antioxidant evaluation, cytotoxicity assessment, and molecular dynamics-based computational studies of novel PABA analogues as dual DHPS/DHFR inhibitors

RSC Adv., 2026, 16,26099-26126
DOI: 10.1039/D6RA01925K, Paper

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Bhargav Devliya, Ahmed K. Al-Kubeisi, Drashti Patel, Milan Dabhi, Bimalkumar Patel, Milan Thakar, Jaykumar Nagapara, Shreya Chauhan, Kiransinh Rajput, Dweipayan Goswami, Nandan Dixit, Saumya K. Patel, Gaurang Sindhav, Botros Y. Beshay, Hitesh D. Patel
Novel PABA-based hybrids were developed as dual DHPS/DHFR inhibitors, showing promising antimicrobial activity against resistant strains supported by experimental and computational studies.
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Inducible secretion of LIGHT by engineered probiotics enables localized cytokine therapy and robust antitumor immunity

RSC Adv., 2026, 16,19511-19523
DOI: 10.1039/D5RA09644H, Paper

Open Access

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Xinyu Li, Shuaijie Ding, Biao Yang, Yi Wang, Wei Xie
Lactic acid-responsive engineered probiotics selectively colonize TNBC tumors. By secreting LIGHT, they remodel the immunosuppressive microenvironment and inhibit tumor growth, which is a promising targeted treatment approach.
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Development of coumarin-sulfonate scaffolds for cholinesterase inhibition: experimental and computational studies toward Alzheimer's disease therapy

RSC Adv., 2026, 16,25819-25832
DOI: 10.1039/D6RA02535H, Paper

Open Access

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Ehsan Ullah Mughal, Nafeesa Naeem, Aneela Shaheen Cheema, Gehan Ahmed Othman, Amina Sadiq, Songül Bayrak, Namık Kılınç, Mohammed B. Hawsawi, Sobhi M. Gomha, Züleyha Almaz
Coumarin-based sulfonate esters (1–9) were synthesized from 4-methyl-7-hydroxycoumarin and characterized by IR/NMR. All compounds showed strong AChE and BChE inhibition with low-nanomolar IC₅₀ values.
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Targeted delivery of gemcitabine to lung cancer cells via a hyaluronic acid-based nanoplatform

RSC Adv., 2026, 16,25944-25963
DOI: 10.1039/D6RA02076C, Paper

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Fengbo Yu, Jingdan Cao, Xingjun Fan, Junxia Gao, Guifang Liu, Chonghuan Lin, Ying Zhu, Qiang Wang
A CD44-targeted nanoplatform (GEM@HA-(HAP/PSI)) with a high drug-loading HAP core and HA–PSI shell enables active targeting, pH-responsive release, CD44-mediated endocytosis, superior in vitro antitumor activity and in vivo tumor suppression.
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Adjunctive therapeutic strategy for in-stent thrombosis: in vitro pharmacodynamic evaluation of COX-1 inhibitor 3d combined with catheter-directed thrombolysis

RSC Adv., 2026, 16,25912-25926
DOI: 10.1039/D6RA01870J, Paper

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Bo Ma, Zenghui Liang, Liping Fu, Yanbiao Ma, Qinghe Sun, Xuchen Lv
Twelve benzohydrazide Schiff base derivatives (3a–3l) with systematic variations in the aromatic aldehyde moiety were designed and synthesized to evaluate their anti-inflammatory, antiplatelet, and in vitro antithrombotic activities.
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Design, synthesis, bioevaluation, and in silico insights of pyrazole-pyrrolinone and pyridazinone hybrids as potential antimicrobial agents

RSC Adv., 2026, 16,25529-25547
DOI: 10.1039/D6RA02508K, Paper

Open Access

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Sayed K. Ramadan, Selwan Hamed, Hoda A. Ahmed, Tarfah Al-Warhi, Nuha S. Alharbi, Eman A. E. El-Helw
This study focused on design and synthesis of novel pyrazole-pyrrolinone and pyridazinone derivatives and evaluation of their antimicrobial, antibiofilm, and mechanistic properties to identify promising lead compounds.
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Designable NIR-II light triggered biocompatible Au NRs for highly efficient photothermal therapy of cervical cancer

RSC Adv., 2026, 16,25705-25716
DOI: 10.1039/D5RA10095J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jiabao Xiong, Hairegu Tuxun, Jiayi Ding, Biao Dong, Nuernisha Alifu
Seed-mediated NIR-II-optimized Au NRs@PEG enabled efficient 1064 nm laser-triggered photothermal therapy with high efficiency, tumor accumulation, low toxicity, and potent tumor inhibition.
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Click chemistry of phenyl 1,2,3-triazole–2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies

RSC Adv., 2026, 16,25330-25347
DOI: 10.1039/D6RA01413E, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Tamer El Malah, Ahmed A. El-Rashedy
Novel phenyl triazole-pyridylpiperazine derivatives were synthesized & tested against cancer cells. Compounds 15 & 18 showed potent anticancer activity comparable to doxorubicin, with favorable ADME profiles & stable EGFR binding.
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One-pot synthesis of fluorescent cap1 mRNAs using labelled trinucleotide m7G-cap analogs for real-time in vitro and in vivo mRNA tracking

RSC Adv., 2026, 16,25548-25556
DOI: 10.1039/D6RA00979D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Chou Yang, Chen Guo, Yiqian Zhou, Suyong Li, Mengjie Li, Yalin Xie, Yanhui Liu, Xinyu Lu, Lijun Zhang, Guoheng Mo, Wei Zhu, Jinlin Hou, Jiancun Zhang
Fluorophore-tagged cap1 analogs provide a practical platform for the one-pot synthesis of trackable mRNAs for cellular imaging and whole-animal distribution studies.
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The utility of pyrimidine derivatives in the construction of azolo[d]pyrimidine: part II-multi-nitrogen azole systems with potential biological applications

RSC Adv., 2026, 16,25459-25484
DOI: 10.1039/D6RA02611G, Review Article

Open Access

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Ahmed H. Shamroukh, Aymn E. Rashad
In this review (part II), we continue our compilation of studies highlighting the use of the pyrimidine ring as a key core precursor for the construction of azolo[d]pyrimidine scaffolds containing more than one nitrogen atom in the azole moiety.
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Itraconazole as a repurposed anti-cancer agent: focusing on synthesis, mechanisms of action and therapeutic insights

RSC Adv., 2026, 16,25651-25674
DOI: 10.1039/D5RA09799A, Review Article

Open Access

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Mahrokh Marzi, Abdolmajid Ghasemian, Ali Ghanbariasad, Ensieh Nournia, Elham Zarenezhad
Cancer drug development faces significant challenges due to long timelines, stringent regulatory requirements, and high failure rates.
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Recent advances of cyanine dyes in tumor theranostics: molecular modification, delivery strategies, and synergistic mechanisms

RSC Adv., 2026, 16,25174-25196
DOI: 10.1039/D6RA02819E, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Dan Zhao, Yaping Xiao, Mengyang Li, Liang Luo
This review summarizes recent advances of cyanine dyes in tumor phototheranostics, focusing on molecular modification and nanostructure construction, delivery strategies, and synergistic mechanisms in integrated platforms for enhancing functionality.
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Benzimidazole derivatives as dual EGFR and BRAFV600E inhibitors with pro-apoptotic antiproliferative potential

RSC Adv., 2026, 16,25216-25228
DOI: 10.1039/D6RA02117D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lamya H. Al-Wahaibi, Mohamed Samir, Stefan Bräse, Bahaa G. M. Youssif, Martha M. Morcoss
Compound 8d exhibited potent dual inhibitory activity against EGFR and BRAF^V600E. It induces apoptosis, with high gastrointestinal absorption.
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Harnessing copper–strontium synergy in an injectable composite for multi-pathway bone regeneration

RSC Adv., 2026, 16,25292-25308
DOI: 10.1039/D6RA01689H, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Zhengqing Zhu, Azin Khodaei, Helen E. King, Harrie Weinans, Saber Amin Yavari
Fabrication of an injectable PVA/alginate dual-network hydrogel loaded with Cu/Sr-doped hydroxyapatite (HA). (A) Synthesis of Cu/Sr-HA. (B) Mechanism of crosslinking. (C) The composite promotes angiogenesis and bone regeneration.
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A QbD-optimized magnetic MOF-chitosan nanocarrier for targeted curcumin delivery and synergistic antimicrobial activity

RSC Adv., 2026, 16,25144-25173
DOI: 10.1039/D6RA02404A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Donia Hemida, Nabila Shehata, Nada Elgiddawy, Haifa E. Alfassam, Samar M. Mahgoub, Rehab Mahmoud
Cur/Fe₃O₄@ZIF-8@CS nanocomposite was designed using Quality by Design route for targeted antimicrobial/anticancer therapy. The composite exhibits high encapsulation efficiency, pH-responsive sustained drug release, & magnetic targeting capability.
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Discovery of Caralluma-derived pregnane glycosides as potent and selective cholinesterase inhibitors: integrated in silico and in vitro evaluation

RSC Adv., 2026, 16,24903-24915
DOI: 10.1039/D6RA01548D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ahmed A. Al-Karmalawy, Mohamed Ibrahim Attia, Radwan Alnajjar, Riham A. El-Shiekh, Arwa Omar Al Khatib, Tarek A. Yousef, Essam Abdel-Sattar
Discovery of Caralluma-derived pregnane glycosides as potent and selective cholinesterase inhibitor.
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Anti-obesity effects of secondary metabolites from Chrysosplenium flagelliferum: in vitro and in silico studies

RSC Adv., 2026, 16,25011-25023
DOI: 10.1039/D6RA00782A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Eun Jin Heo, Bowon Jung, Sunbeom Kwon, Min Yeong Choi, Yoon Seo Jang, Ki Hyun Kim, Gwang Hun Park, Ji Ah Kim, Seulah Lee
Cucurbitacin D (2) and cirsimaritin (6) inhibit lipid accumulation in 3T3-L1 cells by downregulating PPAR-γ. While both target the same receptor, they employ distinct mechanisms: 2 via flexible binding and 6 through stable, compact docking.
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The critical role of hydrogels as an advanced polymeric scaffold in biomedicine: recent progress and challenges

RSC Adv., 2026, 16,25236-25250
DOI: 10.1039/D6RA01314G, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Amir Hatami Kaleshtari, Melika Hasani, Samira Farjaminejad, Rosana Farjaminejad, Amin Foroozandeh, Majid Abdouss, Mohammad Hasanzadeh
Hydrogels have emerged as pivotal materials in biomedical engineering due to their unique properties, including high water content, biocompatibility, and tunable mechanical characteristics.
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Design, synthesis, and antiproliferative activity of novel thiazole-based derivatives as tubulin polymerization inhibitors targeting the colchicine binding site

RSC Adv., 2026, 16,25103-25115
DOI: 10.1039/D6RA01355D, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lamya H. Al-Wahaibi, Ali M. Elshamsy, Taha F. S. Ali, Bahaa G. M. Youssif, Stefan Bräse, Mohamed Abdel-Aziz, Nawal A. El-Koussi
Compound 9k exhibited high potency as an antitubulin agent, with an IC₅₀ value of 1.56 µM, demonstrating double the efficacy of the reference compound CA-4.
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pH-responsive sodium alginate/CMCS/CMCNa composite hydrogel beads for sustained delivery of 5-fluorouracil-β-cyclodextrin inclusion complexes

RSC Adv., 2026, 16,25131-25143
DOI: 10.1039/D6RA00194G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yaling Wu, Peipei Xu, Jing Lin, WanJing Li, Qing Lin, Hanhao Lu, Jingbo Chen, Zhenhua Liu, Yudong Lu
A pH-responsive hydrogel bead system with a dual-locking mechanism (pH-triggered matrix disintegration and host–guest complex dissociation) achieves high loading (81.23%) and ultra-low release (<4%) for precise colon-targeted 5-FU delivery.
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Biological activities of metal oxide nanoparticles modified with hexadeca-substituted cobalt(II) phthalocyanine bearing fluorinated substituents

RSC Adv., 2026, 16,25052-25066
DOI: 10.1039/D6RA01414C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nazlı Farajzadeh Öztürk
For the first time, the extensive DNA-cleavage, antioxidant, antimicrobial, and antidiabetic properties of the newly synthesized hexadeca-substituted metal phthalocyanine/metal oxide nanostructures are reported in this study.
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Photo-immunotherapeutic PDA-Ce6-R837 nanoparticles enhance the induction of immunogenic responses in melanoma cells

RSC Adv., 2026, 16,25067-25080
DOI: 10.1039/D6RA01921H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jianv Wang, Chenxi Liu, Xiaoyan Zhang, Yao Xie, Xueyu Zhang, Tingting Wang, Lin Wang
PDA-Ce6-R837 NP–mediated photo-immunotherapy under dual-wavelength (808/660 nm) irradiation triggers therapeutic release, inducing ICD and DAMPs signaling to promote DC maturation.
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Biodegradable cross-linked flavone networks featuring either ester or carbamate linkages for controlled delivery of anti-cancer agents

RSC Adv., 2026, 16,24986-24996
DOI: 10.1039/D6RA02770A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Mohammed S. H. Alwaezi, Francesca Greco, Helen M. I. Osborn, Wayne Hayes
Cross-linked flavone networks have been generated that degrade under tumour-relevant conditions to demonstrate sustained release of the active flavonoid payloads.
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The antitumor promise of furo[2,3-d]pyrimidine: a 2016–2025 review

RSC Adv., 2026, 16,24808-24821
DOI: 10.1039/D6RA01695B, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mai A. Mansour, Haya A. Elshafei, Alaa S. Sayed, Aya A. Ashour, Nadia E. Hussein, Marwan M. Abdel Karim, Fares M. Kamel, Nada T. Elsayed, Mahmoud R. Ahmed, Mohamed T. Seleem, Rania M. Gomaa
The furopyrimidine scaffold is an emerging core incorporated into numerous anticancer agents.
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Integrated triplex LFIA platform for decentralized molecular subtyping of breast cancer

RSC Adv., 2026, 16,23884-23894
DOI: 10.1039/D6RA02096H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Wenting Gao, Iftak Hussain, Theopisti A. Nikolaou, Samantha Symons, Ganga Dripaul, Monalisa Almeida, Yunting Guo, Sally Adebamowo, Clement Adebamowo, David Erickson
Triplex LFIA integrated with a portable device enables simultaneous quantification of PR, ER, and HER2 for rapid breast cancer subtyping in decentralized settings.
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