RSC - Chem. Sci. latest articles

DNA-polyfluorophore Chemosensors for Environmental Remediation: Vapor-phase Identification of Petroleum Products in Contaminated Soil

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50985K, Edge Article

Wei Jiang, Shenliang Wang, Lik Hang Yuen, Hyukin Kwon, Toshikazu Ono, Eric T Kool
Contamination of soil and groundwater by petroleum-based products is an extremely widespread and important environmental problem. Here we have tested a simple optical approach for detecting and identifying such industrial...
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Synthetic small-molecule walkers at work

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC51160J, Minireview

Dahui Qu, He Tian
The naturally occurring molecular motors have been a source of inspiration for the development of a variety of artificial molecular machines and motors. Synthetic molecular walkers, in which a molecular...
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Using Surfaces to Modulate the Morphology and Structure of Attached Cells - a Case of Cancer Cells on Chitosan Membranes

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50533B, Edge Article

Hung-Hsun Shuai, Chung-Yao Yang, Hans I-Chen Harn, Roger York, Tzu-Chun Liao, Wen-Shiang Chen, Andrew Yeh, Chao-Min Cheng
This paper describes the development of physically and/or chemically modified chitosan membranes to probe cellular behaviors and molecular-level structural responses of NIH-3T3 fibroblasts (normal cells) and Ha-ras-transformed cells (abnormal cells)...
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Asymmetric Synthesis of Propargylic Alcohols via Aldol Reaction of Aldehydes with Ynals Promoted by Prolinol Ether/Transition Metal/Bronsted Acid Cooperative Catalysis

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC51027A, Edge Article

Enrique Gomez, Jesus M. Garcia, Sandra Jimenez, Irati Lapuerta, Antonia Mielgo, Jose Manuel Odriozola, Itziar Otazo, Jesus Razkin, Inaki Urruzuno, Silvia Vera, Mikel Oiarbide, Claudio Palomo
A novel catalytic and highly stereoselective entry to propargylic alcohols and products derived thereof is reported based on an unprecedented cross-aldol coupling between unmodified aldehydes and ynals. The method requires...
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Synthesis and electronic structure of a two dimensional [small pi]-conjugated polythiophene

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50800E, Edge Article

Luis Cardenas, Rico Gutzler, Josh Lipton-Duffin, Chaoying Fu, Jaclyn L Brusso, Laurentiu E Dinca, Martin Vondracek, Yannick Fagot-Revurat, Daniel Malterre, Federico Rosei, Dmitrii Perepichka
We report the synthesis and first electronic characterization of an atomically thin two dimensional [small pi]-conjugated polymer. Polymerization via Ullmann coupling of a tetrabrominated tetrathienoanthracene on Ag(111) in ultra-high vacuum (UHV)...
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Bottom-up synthesis and structures of [small pi]-lengthened tubular macrocycles

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50645B, Edge Article

Taisuke Matsuno, Sho Kamata, Shunpei Hitosugi, Hiroyuki Isobe
Belt-persistent tubular cycloarylenes possessing extended sp²-networks of finite single-wall carbon nanotube (SWNT) have been synthesised from an abundantly available pigment possessing dibenzo[def,mno]chrysene (anthanthrene) framework. The introduction of bulky substituents allowed...
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Silver-Mediated Fluorination, Trifluoromethylation, and Trifluoromethylthiolation of Arynes

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50992C, Edge Article

Daesung Lee, Kung-Pern Wang, Sang Young Yun, Phani Mamidipalli
General approaches for fluorination, trifluoromethylation, and trifluoromethylthiolation were developed based on the electrophilic nature of arynes. In these reactions, the addition of fluorine-containing nucleophiles onto aryne intermediates was efficiently promoted...
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Palladium-Catalyzed Intermolecular Fluoroesterification of Styrenes: Exploration and Mechanistic Insight

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50690H, Edge Article

Guosheng Liu, Haihui Peng, Hao-Yang Wang, Yin-Long Guo, Zheliang Yuan
A novel palladium-catalyzed intermolecular oxidative fluoroesterification of vinylarenes has been developed with NFSI, one of the mildest electrophilic fluorinating reagents. The reaction presented an efficient synthetic pathway to afford a...
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Catalytic hydrotrifluoromethylation of styrenes and unactivated aliphatic alkenes via an organic photoredox system

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC51209F, Edge Article

Dale J. Wilger, Nathan J. Gesmundo, David Nicewicz
Herein is presented a direct method for the metal-free hydrotrifluoromethylation of alkenes. The method relies on the single electron oxidation of a commercially available sodium trifluoromethanesulfinate salt (CF3SO2Na, Langlois reagent)...
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Carbene-Stabilized Main Group Radicals and Radical Ions

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC51174J, Minireview

Caleb D Martin, Michele Soleilhavoup, Guy Bertrand
Shortly after their discovery at the end of the 80s, stable singlet carbenes have been recognized as excellent ligands for transition metal based catalysts, and as organo-catalysts in their own...
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End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50859E, Edge Article

David R. Snead, Timothy F. Jamison
Heating neat starting materials above product melting point directly synthesizes desired salt form as a free-flowing molten ammonium salt and obviates solvent. In-line purification and crystallization minimizes production time and user intervention.
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Nitrogen-doped carbon nanotubes derived from Zn-Fe-ZIF nanospheres and their application as efficient oxygen reduction electrocatalysts with in situ generated iron species

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC51052B, Edge Article

Panpan Su, Hui Xiao, Jiao Zhao, Yi Yao, Zhigang Shao, Can Li, Qihua Yang
Nitrogen-doped carbon nanotubes synthesized via the pyrolysis of Zn-Fe-ZIF are efficient electrocatalysts for the oxygen reduction reaction with graphitic N and in situ generated iron species.
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A highly selective and sensitive near-infrared fluorescence probe for arylamine N-acetyltransferase 2 in vitro and in vivo

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC51079D, Edge Article

Xin Wang, Lei Cui, Nannan Zhou, Weiping Zhu, Rui Wang, Xuhong Qian, Yufang Xu
Detection and imaging of metabolic enzyme: a near-infrared fluorescent probe exhibited significant response to NAT2 cytosol and liver homogenate and displayed excellent NAT2 imaging in living mice.
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Towards predictable transmembrane transport: QSAR analysis of anion binding and transport

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC51023A, Edge Article

Nathalie Busschaert, Samuel J. Bradberry, Marco Wenzel, Cally J. E. Haynes, Jennifer R. Hiscock, Isabelle L. Kirby, Louise E. Karagiannidis, Stephen J. Moore, Neil J. Wells, Julie Herniman, G. John Langley, Peter N. Horton, Mark E. Light, Igor Marques, Paulo J. Costa, Vitor Felix, Jeremy G. Frey, Philip A. Gale
QSAR analysis of anion transport is used to show which molecular parameters govern efficient transport.
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Simple DNA-based logic gates responding to biomolecules and metal ions

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50924A, Perspective

Ma Dik-Lung, Hong-Zhang He, Shiu-Hin Daniel Chan, Chung-Hang Leung
The combination of chemical and molecular technologies to emulate silicon-based processing has arisen as a fascinating area of research in the scientific community. This has stimulated the development of molecular-scale...
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Photoinduced Direct 4-Pyridination of C(sp3)-H Bonds

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC51080H, Edge Article

Tamaki Hoshikawa, Masayuki Inoue
Direct substitution of hydrogen in C(sp3)-H bonds by 4-pyridine was achieved by employing benzophenone and 4-cyanopyridine in aqueous acetonitrile under photo-irradiating conditions. This simple and mild 4-pyridination proceeds in a...
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Controlled modulation of the helical sense and the elongation of poly(phenylacetylene)s by polar and donor effects

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50835H, Edge Article

Seila Leiras, Felix Freire, Jose M. Seco, Emilio Quinoa, Ricardo Riguera
Helical sense and elongation of a poly(phenylacetylene) is selectively controlled by the donor and the polar character of the solvent.
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Exohedrally stabilized C70 isomer with adjacent pentagons characterized by crystallography

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50141H, Edge Article

Yuan-Zhi Tan, Jia Li, Ming-Yue Du, Shui-Chao Lin, Su-Yuan Xie, xin Lu, Rong-Bin Huang, Lansun Zheng
All the C₇₀ isomers other than the well-known D_5h-symmetric C₇₀ (#8149) are highly elusive due to their defiance to the Isolated Pentagon Rule (IPR), and, in turn, have long been...
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Two polymeric 36-nuclear pure lanthanide nano-size clusters

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50887K, Edge Article

Mingyan Wu, Feilong Jiang, Xiang-Jian Kong, Daqiang Yuan, Maochun Hong
Two rarely-seen 2D coordination polymers based on huge 36-nuclearity pure lanthanide clusters, {[Gd₃₆(NA)₃₆(OH)₄₉(O)₆(NO₃)₆(N₃)₃(H₂O)₂₀]Cl₂[middle dot]28H₂O}_n(1) and {[Dy₃₆(NA)₃₆(OH)₄₉(O)₆(NO₃)₆(N₃)₃(H₂O)₂₀]Cl₂[middle dot]28H₂O}_n(2) (HNA = nicotinic acid ), were synthesized and structurally charaterized. The spheric Ln₃₆...
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Biological activity of synthetic ionophores: ion transporters as prospective drugs?

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50882J, Perspective

Ignacio Alfonso, Roberto Quesada
The control of ion transport and homeostasis is a critical function of living organisms. In this minireview, an overview of different synthetic systems capable of facilitating the transmembrane transport of...
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Intramolecular versus Intermolecular Electronic Interactions between [5,6]-open and [6,6]-closed C60 Adducts with exTTF

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC00004D, Edge Article

Yuta Takano, Christina Schubert, Naomi Mizorogi, Lai Feng, Azusa Iwano, Mikimasa Katayama, M. Angeles Herranz, Dirk Guldi, Nazario Martin, Shigeru Nagase, Takeshi Akasaka
Intramolecular and intermolecular electronic interactions are important concepts for fabricating fullerene-based nanostructures such as bulk heterojunction (BHJ) solar cells and supramolecular assemblies. To ascertain differences of the molecular interactions depending...
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Realizing the Promise of Chemical Glycobiology

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50877C, Minireview

Lai-Xi Wang, Benjamin G Davis
Chemical glycobiology is emerging as one of the most uniquely powerful sub-disciplines of chemical biology. The previous scarcity of chemical strategies and the unparalleled structural diversity have created a uniquely...
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Electron Transfer/Ion Transfer Mode of Scanning Electrochemical Microscopy (SECM): a New Tool for Imaging and Kinetic Studies

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50825K, Edge Article

Yixian Wang, Kaan Kececi, Jeyavel Velmurugan, Michael V. Mirkin
A new mode of the scanning electrochemical microscope (SECM) operation was developed that combines reagent delivery from the nanopipette with electron transfer at the conductive substrate and ion transfer across...
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Phosphate derivative-induced supramolecular assembly and NIR-emissive behaviour of alkynylplatinum(II) terpyridine complexes for real-time monitoring of enzymatic activities

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50383F, Edge Article

Margaret Ching-Lam Yeung, Vivian Wing-Wah Yam
The phosphate derivative-induced supramolecular assembly properties of NIR-emissive alkynylplatinum(II) terpyridine complexes provide a convenient protocol for real-time monitoring of enzymatic activities.
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Photocontrolled template-directed synthesis of complementary double helices assisted by amidinium-carboxylate salt bridge formation

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50833A, Edge Article

Eiji Yashima, Junki Tanabe, Daisuke Taura, Hidekazu Yamada, Yoshio Furusho
The template-directed imine-bond forming reactions between chiral amidines or achiral carboxylic acids monomers bearing a formyl or an amino group at one end were remarkably accelerated 34- or 10-fold in...
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Synthetically defined glycoprotein vaccines: current status and future directions

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50862E, Perspective

Roberto Adamo, Alberto Nilo, Bastien Castagner, Omar Boutureira, Francesco Berti, Goncalo J. L. Bernardes
We highlight current glycovaccines in the clinic and derive principles for the construction of the next generation of synthetically defined glycoconjugate vaccines.
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A Chiral Porous Metallosalan-Organic Framework Containing Titanium-Oxo Clusters for Enantioselective Catalytic Sulfoxidation

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50487E, Edge Article

Yong Cui, Weimin Xuan, Chengcheng Ye, Mengni Zhang, Zhijie Chen
A chiral porous zeolite-like metal-organic framework is constructed by using a mixed ligands of dipyridyl-functionalized chiral Ti(salan) and biphenyl-4,4'-dicarboxylate. The framework containing salan-bound Ti4O6 clusters consists of both hydrophobic and...
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Programmable Multilayers of Nanometer-Sized Macrocycles on Solid Support and Stimuli-Controlled On-Surface Pseudorotaxane Formation

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50558H, Edge Article

Johannes Poppenberg, Sebastian Richter, Christoph H.-H. Traulsen, Erik Darlatt, Baytekin Bilge, Thomas Heinrich, Peter Deutinger, Katharina Huth, Wolfgang Unger, Christoph A Schalley
Mechanically interlocked molecules (MIMs) such as rotaxanes and catenanes are capable of mechanical motion on the nanoscale and are therefore promising prototypes for molecular machines in recent nanotechnology. However, most...
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Ammonia Decomposition by Ruthenium Nanoparticles Loaded on Inorganic Electride C12A7:e-

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50794G, Edge Article

Fumitaka Hayashi, Yoshitake Toda, Yoshimi Kanie, Masaaki Kitano, Yasunori Inoue, Toshiharu Yokoyama, Michikazu Hara, Hideo Hosono
The use of ammonia as a hydrogen carrier has received much attention due to its high hydrogen content and liquid state under mild conditions, which could lead to fuel cell...
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Combining Myeloperoxidase (MPO) with Fluorogenic ZnSalen to Detect Lysosomal Hydrogen Peroxide in Live Cells

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50807B, Edge Article

Jun-Long Zhang, Jing Jing
Accumulating evidence suggests that lysosomal H2O2 is closely associated with autophagy and apoptosis in normal and pathological processes. Imaging H2O2 in lysossomes is a powerful tool to elucidate its diverse...
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Iridium-catalyzed regiospecific and stereospecific allylic amination for the syntheses of [small alpha],[small beta]-unsaturated [gamma]-amino esters and the bifurcation of the reaction pathway leading to the formation of oxazolidin-2-ones

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50901J, Edge Article

Jun Hee Lee, Sang-gi Lee
A bifurcation of reaction pathways in Ir-catalyzed regio- and stereospecific amination reactions has been developed.
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Grafting a homogeneous transition metal catalyst onto a silicon AFM probe: a promising strategy for chemically constructive nanolithography

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50979F, Edge Article

Dmitry A. Valyaev, Sylvain Clair, Lionel Patrone, Mathieu Abel, Louis Porte, Olivier Chuzel, Jean-Luc Parrain
Selective lithography using an atomic force microscope (AFM) probe with an immobilized homogeneous catalyst gives access to nanoscale transformations of the surface.
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A theoretical and experimental examination of systematic ligand-induced disorder in Au dendrimer-encapsulated nanoparticles

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50614B, Edge Article

David F. Yancey, Samuel T. Chill, Liang Zhang, Anatoly I. Frenkel, Graeme Henkelman, Richard M. Crooks
A combined experimental/theoretical approach was used to study the structure of thiol coated dendrimer encapsulated nanoparticles. DFT-MD simulations were validated against experimental structures using EXAFS analysis.
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Cation-directed enantioselective synthesis of quaternary-substituted indolenines

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50592H, Edge Article

Meiling Li, Philip A. Woods, Martin D. Smith
An asymmetric method for the synthesis of quaternary-substituted indolenines via a 5-endo-dig cyclization of an [small alpha]-cyanocarbanion onto an isonitrile has been developed.
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Chemical fidelity of an RNA polymerase ribozyme

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50574J, Edge Article

James Attwater, Shunsuke Tagami, Michiko Kimoto, Kyle Butler, Eric T. Kool, Jesper Wengel, Piet Herdewijn, Ichiro Hirao, Philipp Holliger
We challenge a polymerase ribozyme with an array of nucleotide variants to assess its tolerance of substrate heterogeneity. We uncover specificity determinants, and describe the implications for primordial RNA replication.
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Direct observation of a cationic ruthenium complex for ethylene insertion polymerization

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50676B, Edge Article

Miguel A. Camacho-Fernandez, Max Yen, Joseph W. Ziller, Zhibin Guan
We report the first direct observation of a cationic ruthenium complex catalyzing ethylene insertion polymerization.
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An enantioselective tandem reduction/nitro-Mannich reaction of nitroalkenes using a simple thiourea organocatalyst

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50613D, Edge Article

James C. Anderson, Paul J. Koovits
A superior and more user friendly nitro-Mannich reaction was developed by combining two catalytic transformations into one tandem process.
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The Role of Solvent Cohesion in Nonpolar Solvation

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50740H, Edge Article

Sijbren Otto
Understanding hydrophobic interactions requires a molecular-level picture of how water molecules adjust to the introduction of a nonpolar solute. New insights into the latter process are derived from the observation...
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New fluorescent probes for sulfane sulfurs and the application in bioimaging

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50754H, Edge Article

Wei Chen, Chunrong Liu, Bo Peng, Yu Zhao, Armando Pacheco, Ming Xian
This work reports the design, synthesis, and evaluation of the first fluorescent probes for the detection of sulfane sulfur species.
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A light-assisted, polymeric water oxidation catalyst that selectively oxidizes seawater with a low onset potential

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50812A, Edge Article

Jun Chen, Pawel Wagner, Lei Tong, Danijel Boskovic, Weimin Zhang, David Officer, Gordon G. Wallace, Gerhard F. Swiegers
PEDOT doped with a sulphonated Mn porphyrin catalyzes selective oxidation of water in seawater from ca. 0.40 V (vs. NHE).
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Dynamic and bio-orthogonal protein assembly along a supramolecular polymer

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50891A, Edge Article

Katja Petkau-Milroy, Dana A. Uhlenheuer, A. J. H. Spiering, Jef A. J. M. Vekemans, Luc Brunsveld
Adaptable, multivalent protein assemblies were generated using supramolecular polymers based on monovalent discotics. The self-assembling protein-conjugated discotics show dynamic intermixing, allowing facile assembly formation and tuning of distance between proteins.
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Halogen photoelimination from dirhodium phosphazane complexes via chloride-bridged intermediates

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50462J, Edge Article

David C. Powers, Matthew B. Chambers, Thomas S. Teets, Noemie Elgrishi, Bryce L. Anderson, Daniel G. Nocera
Transient absorption studies have revealed chloride-bridged intermediates in photoelimination from dirhodium complexes during photochemical HX splitting.
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A two-step approach to the synthesis of N@C60 fullerene dimers for molecular qubits

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50395J, Edge Article

Simon Plant, Martyn Jevric, John Morton, Arzhang Ardavan, Andrei N Khlobystov, Andrew Briggs, Kyriakos Porfyrakis
We report the two-step synthesis of a highly soluble fullerene dimer, both for short reaction times and at the microscale. We apply this reaction scheme to starting materials that contain...
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Electronic effects of triarylphosphines in metal-free hydrogen activation: a kinetic and computational study

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50347J, Edge Article

Lutz Greb, Sebastian Tussing, Birgitta Schirmer, Pascual Ona-Burgos, Karl Kaupmees, Mart Lokov, Ivo Leito, Stefan Grimme, Jan Paradies
Less electron-releasing phosphines lead to reversible FLP-mediated low-temperature H₂-activation and different kinetic behaviour in olefin hydrogenation.
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A dinuclear silver hydride and an umpolung reaction of CO2

Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC50896J, Edge Article

Brandon K. Tate, Chelsea M Wyss, John Bacsa, Kelly Kluge, Leslie Gelbaum, Joseph Sadighi
A triangular [Ag₂H]+ core is stabilised by the N-heterocyclic carbene (NHC) ligand 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene (SIDipp). The X-ray crystal structure of this complex reveals a short silver-silver distance, and ¹⁰⁹Ag NMR spectroscopy...
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Rhodium(III)-catalyzed intramolecular annulations involving amide-directed C-H activations: synthetic scope and mechanistic studies

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC51078F, Edge Article

Noelia Quinones, Andres Seoane, Rebeca Garcia-Fandino, Jose Luis Mascarenas, Moises Gulias
Alkyne tethered benzamides undergo rhodium(III)-catalyzed intramolecular annulations to give tricyclic isoquinoline derivatives in good yields.
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Carbocyclization of unsaturated thioesters under palladium catalysis

Chem. Sci., 2013, 4,2686-2689
DOI: 10.1039/C3SC50486G, Edge Article

Arun P. Thottumkara, Toshiki Kurokawa, J. Du Bois
An intramolecular thioester-olefin cross-coupling reaction for the preparation of cyclic ketone derivatives is described.
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Iridium(III)-bis(oxazolinyl)phenyl catalysts for enantioselective C-H functionalization

Chem. Sci., 2013, 4,2590-2596
DOI: 10.1039/C3SC50886B, Edge Article

Clayton P. Owens, Adrian Varela-Alvarez, Vyacheslav Boyarskikh, Djamaladdin G. Musaev, Huw M. L. Davies, Simon B. Blakey
A family of iridium(III)-bis(oxazolinyl)phenyl complexes has been developed to catalyze enantioselective C-H functionalization reactions. DFT studies provide evidence for an axially bound carbene and provide a unique model for stereoinduction in atom transfer reactions employing bis(oxazolinyl)phenyl ligands.
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Access to congested quaternary centers by Pd-catalyzed intermolecular [gamma]-arylation of unactivated [small alpha],[small beta]-unsaturated aldehydes

Chem. Sci., 2013, 4,2619-2624
DOI: 10.1039/C3SC50806D, Edge Article

Ivan Franzoni, Laure Guenee, Clement Mazet
A palladium-catalyzed intermolecular [gamma]-arylation of [gamma]-branched [small alpha],[small beta]-unsaturated aldehydes has been developed.
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Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)-H bonds and aryl C(sp2)-H bonds using TBHP

Chem. Sci., 2013, 4,2690-2694
DOI: 10.1039/C3SC50810B, Edge Article

Ming-Bo Zhou, Ren-Jie Song, Xuan-Hui Ouyang, Yu Liu, Wen-Ting Wei, Guo-Bo Deng, Jin-Heng Li
A novel metal-free oxidative tandem coupling of alkenes with carbonyl C(sp²)-H bonds and aryl C(sp²)-H bonds is presented.
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The transition from liquid to solid-like behaviour in ultrahigh viscosity aerosol particles

Chem. Sci., 2013, 4,2597-2604
DOI: 10.1039/C3SC50682G, Edge Article

R. M. Power, S. H. Simpson, J. P. Reid, A. J. Hudson
The timescale for relaxation of supersaturated aerosol particles following optically induced coalescence allows measurement of viscosity over 12 decades.
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Synthesis of cyclobutane lignans via an organic single electron oxidant-electron relay system

Chem. Sci., 2013, 4,2625-2629
DOI: 10.1039/C3SC50643F, Edge Article

Michelle Riener, David A. Nicewicz
A direct method to synthesize bioactive lignan cyclobutanes and analogs via a photoinduced electron transfer method is presented.
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A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Chem. Sci., 2013, 4,2605-2612
DOI: 10.1039/C3SC50554E, Edge Article

Jinzhuan Wang, Xiaoyong Wang, Yajie Song, Jing Wang, Changli Zhang, Cunjie Chang, Jun Yan, Lin Qiu, Mingmin Wu, Zijian Guo
A cisplatin-tethered superparamagnetic nanocomposite with antitumor and magnetic resonance imaging properties preferentially accumulates in tumor tissues in the presence of an external magnetic field.
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Rhodium-catalyzed hydroformylation of alkynes employing a self-assembling ligand system

Chem. Sci., 2013, 4,2418-2422
DOI: 10.1039/C3SC50725D, Edge Article

Vladislav Agabekov, Wolfgang Seiche, Bernhard Breit
Hydroformylation of alkynes is an atom-economic and redox-neutral method to prepare enals. Applying a new electron poor self-assembling ligand system provides the first general rhodium-catalyst for the chemo- and stereoselective hydroformylation of dialkyl- as well as diaryl-substituted alkynes to furnish enals in excellent chemo- and stereoselectivity.
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cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity

Chem. Sci., 2013, 4,2613-2618
DOI: 10.1039/C3SC50666E, Edge Article

Xingkuan Chen, Xinqiang Fang, Yonggui Robin Chi
cis-Enals show different stereoselectivity and distinct reactivity under NHC organocatalysis, when compared to the corresponding trans-enals.
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Remarkable coordination behavior of alkyl isocyanides toward unsaturated vicinal frustrated P/B Lewis pairs

Chem. Sci., 2013, 4,2657-2664
DOI: 10.1039/C3SC00082F, Edge Article

Olga Ekkert, Greco Gonzalez Miera, Thomas Wiegand, Hellmut Eckert, Birgitta Schirmer, Jeffrey L. Petersen, Constantin G. Daniliuc, Roland Frohlich, Stefan Grimme, Gerald Kehr, Gerhard Erker
The conjugated frustrated Lewis pairs 3 formed by 1,1-carboboration undergo a synergistic 1,1-addition reaction to n-butyl isocyanide.
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Well-defined silica-supported molybdenum nitride species: silica grafting triggers alkyne metathesis activity

Chem. Sci., 2013, 4,2680-2685
DOI: 10.1039/C3SC50325A, Edge Article

Marie Genelot, Nicolas P. Cheval, Marta Vitorino, Elise Berrier, Jean-Marc Weibel, Patrick Pale, Andre Mortreux, Regis M. Gauvin
The grafting of a molybdenum nitride complex onto highly dehydroxylated silica proceeds to the formation of well-defined silica-supported species that display high activity in alkyne metathesis, contrary to the inert molecular precursor.
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Engineering of thiocyanate-free Ru(II) sensitizers for high efficiency dye-sensitized solar cells

Chem. Sci., 2013, 4,2423-2433
DOI: 10.1039/C3SC50399B, Edge Article

Sheng-Wei Wang, Kuan-Lin Wu, Elham Ghadiri, Maria Grazia Lobello, Shu-Te Ho, Yun Chi, Jacques-E. Moser, Filippo De Angelis, Michael Gratzel, Mohammad K. Nazeeruddin
We synthesized a series of Ru(II) metal complexes with a single 4,4[prime or minute]-dicarboxylic acid-2,2[prime or minute]-bipyridine and two functionalized pyridyl azolate ancillary ligands consisting of pyrazolate or triazolate groups, which yield an overall conversion efficiency of 10.2%.
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One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method

Chem. Sci., 2013, 4,2573-2580
DOI: 10.1039/C3SC50560J, Edge Article

Kazuya Matsuo, Yoshiyuki Kioi, Ryosuke Yasui, Yousuke Takaoka, Takayuki Miki, Sho-hei Fujishima, Itaru Hamachi
We examine in detail the reaction characteristics of ligand-directed acyl imidazole chemistry using carbonic anhydrase I as a model enzyme.
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Squaraine rotaxane shuttle as a ratiometric deep-red optical chloride sensor

Chem. Sci., 2013, 4,2557-2563
DOI: 10.1039/C3SC50535A, Edge Article

Carleton G. Collins, Evan M. Peck, Patrick J. Kramer, Bradley D. Smith
A new squaraine rotaxane molecular shuttle acts as a deep-red, fluorescent and colorimetric sensor for Cl^- anion with reversible, ratiometric response that can be detected easily by the naked eye.
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Synthesis of nitrodienes, nitrostyrenes, and nitrobiaryls through palladium-catalyzed couplings of [small beta]-nitrovinyl and o-nitroaryl thioethers

Chem. Sci., 2013, 4,2670-2674
DOI: 10.1039/C3SC50773D, Edge Article

Gardner S. Creech, Ohyun Kwon
A base-free, mild protocol for the palladium-catalyzed, copper-activated desulfitative couplings of vinyl and aryl [small beta]-nitrothioethers generates nitrodienes, nitrostyrenes, and nitrobiaryls.
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A new and more powerfully activating diamine for practical and scalable enantioselective aldehyde crotylsilylation reactions

Chem. Sci., 2013, 4,2413-2417
DOI: 10.1039/C3SC50714A, Edge Article

Linda M. Suen, Michael L. Steigerwald, James L. Leighton
We describe a new diamine for enantioselective aldehyde crotylsilylation reactions that makes possible a convenient one-pot procedure, and calculations that suggest the activity derives from the modulation of stereoelectronic effects by conformational constraints.
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Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C-H bond activation

Chem. Sci., 2013, 4,2675-2679
DOI: 10.1039/C3SC50577D, Edge Article

Chao Pi, Ying Li, Xiuling Cui, Hao Zhang, Yanbing Han, Yangjie Wu
An asymmetric dehydrogenative Heck reaction controlled by redox process of ferrocene has been developed, affording planar-chiral ferrocenes with excellent enantioselectivity.
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Enantioselective intermolecular bromoesterification of allylic sulfonamides

Chem. Sci., 2013, 4,2652-2656
DOI: 10.1039/C3SC50446H, Edge Article

Wei Zhang, Na Liu, Casi M. Schienebeck, Xin Zhou, Izarin I. Izhar, Ilia A. Guzei, Weiping Tang
Highly enantioselective intermolecular bromoesterification of alkenes was achieved for the first time.
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Glucose conjugation for the specific targeting and treatment of cancer

Chem. Sci., 2013, 4,2319-2333
DOI: 10.1039/C3SC22205E, Minireview

Emilia C. Calvaresi, Paul J. Hergenrother
This minireview discusses current progress in, and important considerations for, the emerging field of glycoconjugated anticancer therapeutics.
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O-H bond fission in 4-substituted phenols: S1 state predissociation viewed in a Hammett-like framework

Chem. Sci., 2013, 4,2434-2446
DOI: 10.1039/C3SC50296A, Edge Article

Tolga N. V. Karsili, Andreas M. Wenge, Stephanie J. Harris, Daniel Murdock, Jeremy N. Harvey, Richard N. Dixon, Michael N. R. Ashfold
The probability of O-H bond fission following excitation to the S₁ state of phenol is sensitively and predictably dependent on 4-substitution.
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Rh(III)-catalyzed ortho-oxidative alkylation of unactivated arenes with allylic alcohols

Chem. Sci., 2013, 4,2665-2669
DOI: 10.1039/C3SC50630D, Edge Article

Liangbin Huang, Qian Wang, Ji Qi, Xia Wu, Kefan Huang, Huanfeng Jiang
Rh(III)-catalyzed C-H alkylation to afford [small beta]-aryl ketones, and carboamination of the allylic alcohols with acetanilides to obtain 1,2-disubstituted indolines.
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A near-infrared ratiometric fluorescent probe for rapid and highly sensitive imaging of endogenous hydrogen sulfide in living cells

Chem. Sci., 2013, 4,2551-2556
DOI: 10.1039/C3SC50369K, Edge Article

Xu Wang, Juan Sun, Weihong Zhang, Xiaoxu Ma, Jianzheng Lv, Bo Tang
A near-infrared and highly sensitive fluorescent probe that can target mitochondria has been used to ratiometrically visualize endogenous H₂S in living cells.
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Structure elucidation and control of cyclic peptide-derived nanotube assemblies in solution

Chem. Sci., 2013, 4,2581-2589
DOI: 10.1039/C3SC00064H, Edge Article

Robert Chapman, Ming Liang Koh, Gregory G. Warr, Katrina A. Jolliffe, Sebastien Perrier
We describe the solution assembly of polymer-cyclic peptide conjugates into nanotubes, by direct in situ measurements.
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Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimer's disease treatment

Chem. Sci., 2013, 4,2536-2542
DOI: 10.1039/C3SC50697E, Edge Article

Meng Li, Peng Shi, Can Xu, Jinsong Ren, Xiaogang Qu
A novel double delivery platform has been presented by combining the anti-aggregation property of metal chelators and anti-oxidant property of CeO₂NPs in one system for Alzheimer's disease treatment.
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Highly porous and stable metal-organic frameworks for uranium extraction

Chem. Sci., 2013, 4,2396-2402
DOI: 10.1039/C3SC50230A, Edge Article

Michael Carboni, Carter W. Abney, Shubin Liu, Wenbin Lin
Three metal-organic frameworks (MOFs) of the UiO-68 network topology were prepared using the amino-TPDC or TPDC bridging ligands containing orthogonal phosphorylurea groups (TPDC is p,p[prime or minute]-terphenyldicarboxylic acid), and investigated for sorption of uranium from water and artificial seawater.
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Thermodynamic and kinetic specificities of ligand binding

Chem. Sci., 2013, 4,2387-2395
DOI: 10.1039/C3SC50478F, Edge Article

Zhiqiang Yan, Xiliang Zheng, Erkang Wang, Jin Wang
The equivalence of conventional and intrinsic specificities of protein-ligand binding if the N- and C-terminus of multiple protein receptors are linked together with one another.
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Light-emitting platinum(II) complexes supported by tetradentate dianionic bis(N-heterocyclic carbene) ligands: towards robust blue electrophosphors

Chem. Sci., 2013, 4,2630-2644
DOI: 10.1039/C3SC21822H, Edge Article

Kai Li, Gang Cheng, Chensheng Ma, Xiangguo Guan, Wai-Ming Kwok, Yong Chen, Wei Lu, Chi-Ming Che
This work reports extensive synthetic, structural, photophysical and DFT calculation studies on Pt(II) complexes with tetradentate bis(NHC) ligands, together with a highly efficient Pt(II) blue-emitting OLED.
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Characterization of silver ion dissolution from silver nanoparticles using fluorous-phase ion-selective electrodes and assessment of resultant toxicity to Shewanella oneidensis

Chem. Sci., 2013, 4,2564-2572
DOI: 10.1039/C3SC50320H, Edge Article

Melissa A. Maurer-Jones, Maral P. S. Mousavi, Li D. Chen, Philippe Buhlmann, Christy L. Haynes
Silver nanoparticle (Ag NP) dissolution, or ionization from Ag(0) to Ag⁺, is an important determinant of the nanoparticles' toxicity as silver ions are considered to be a major contributor to Ag NP cytotoxicity.
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Epitaxial growth and enhanced conductivity of an IT-SOFC cathode based on a complex perovskite superstructure with six distinct cation sites

Chem. Sci., 2013, 4,2403-2412
DOI: 10.1039/C3SC21931C, Edge Article

R. Sayers, N. L. O. Flack, J. Alaria, P. A. Chater, R. G. Palgrave, S. R. C. McMitchell, S. Romani, Q. M. Ramasse, T. J. Pennycook, M. J. Rosseinsky
Epitaxial thin films of the 10 layer cubic perovskite superstructure Ba_1.7Ca_2.4Y_0.9Fe₅O₁₃ were grown by pulsed laser deposition, retaining the six distinct cation sites found in the bulk material.
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Top-contacting molecular monolayers using single crystalline Au microplate electrodes

Chem. Sci., 2013, 4,2530-2535
DOI: 10.1039/C3SC00058C, Edge Article

Radha Boya, Deepak Jayaraj, Giridhar U. Kulkarni
A molecular sandwich device was fabricated for off-the-shelf usage with chemically synthesized single crystalline electrodes.
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Highly efficient one-pot ligation and desulfurization

Chem. Sci., 2013, 4,2496-2501
DOI: 10.1039/C3SC50239B, Edge Article

Tal Moyal, Hosahalli P. Hemantha, Peter Siman, Maya Refua, Ashraf Brik
Presented here are two highly efficient methods for carrying out ligation and desulfurization reactions in one-pot and the application of these approaches in the synthesis of ubiquitin and di-ubiquitin proteins.
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C-H[small pi] interactions as modulators of carbocation structure - implications for terpene biosynthesis

Chem. Sci., 2013, 4,2512-2518
DOI: 10.1039/C3SC50571E, Edge Article

Young J. Hong, Dean J. Tantillo
C-H bonds involved in strong hyperconjugation are shown to be strong C-H[small pi] donors and their participation in C-H[small pi] interactions with specific geometries is shown to promote large modifications to the structures of carbocations relevant to terpene biosynthesis.
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Understanding the competitive dehydroalkoxylation and dehydrogenation of ethers with Ti-C multiple bonds

Chem. Sci., 2013, 4,2543-2550
DOI: 10.1039/C3SC22195D, Edge Article

Marco G. Crestani, Andras Olasz, Balazs Pinter, Brad C. Bailey, Skye Fortier, Xinfeng Gao, Chun-Hsing Chen, Mu-Hyun Baik, Daniel J. Mindiola
The transient titanium neopentylidyne, (PNP)Ti[triple bond, length as m-dash]C^tBu (A) (PNP = N[2-PⁱPr₂-4-methylphenyl]₂^-), exhibits competing dehydrogenation and dehydroalkoxylation reaction pathways in the presence of acyclic ethers.
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On the evaporation, bonding, and adsorbate capture of an ionic liquid on Au(111)

Chem. Sci., 2013, 4,2519-2529
DOI: 10.1039/C3SC00072A, Edge Article

Stephen G. Hessey, Robert G. Jones
We capture and then desorb a small adsorbate (acetone) from within a thin layer of ionic liquid on a Au(111) surface.
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Unraveling the peculiar modus operandi of a new class of solvatochromic fluorescent molecular rotors by spectroscopic and quantum mechanical methods

Chem. Sci., 2013, 4,2502-2511
DOI: 10.1039/C3SC50290B, Edge Article

Matthias Koenig, Giovanni Bottari, Giuseppe Brancato, Vincenzo Barone, Dirk M. Guldi, Tomas Torres
A prototype for a new class of fluorescent molecular rotors, namely 4-(diphenylamino)phthalonitrile (DPAP), was synthesized and its sensitivity towards solvent polarity and viscosity probed using photophysical and computational methods.
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First demonstration of two-step FRET in a synthetic supramolecular assembly

Chem. Sci., 2013, 4,2380-2386
DOI: 10.1039/C3SC50282A, Edge Article

Moorthy Suresh, Amal Kumar Mandal, E. Suresh, Amitava Das
Sequential two step FRET (1 [rightward arrow] 2 [rightward arrow] 3) in a triad along with direct FRET (1 [rightward arrow] 3) processes in a self-assembled [2]pseudorotaxane complex is demonstrated.
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Induced self-assembly and disassembly of water-soluble alkynylplatinum(II) terpyridyl complexes with "switchable" near-infrared (NIR) emission modulated by metal-metal interactions over physiological pH: demonstration of pH-responsive NIR luminescent probes in cell-imaging studies

Chem. Sci., 2013, 4,2453-2462
DOI: 10.1039/C3SC50196E, Edge Article

Clive Yik-Sham Chung, Steve Po-Yam Li, Man-Wai Louie, Kenneth Kam-Wing Lo, Vivian Wing-Wah Yam
Induced self-assembly of platinum(II) complexes shows "switchable" NIR emission over physiological pH both in solutions and in cells.
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Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

Chem. Sci., 2013, 4,2645-2651
DOI: 10.1039/C3SC50604E, Edge Article

Gen Zhang, Yunxia Ma, Shoulei Wang, Weidong Kong, Rui Wang
A novel chiral organic contact ion-pair catalytic system has been developed for the transition-metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones for sp³ C-H functionalization.
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C-H activation route to dibenzo[a,e]pentalenes: annulation of arylacetylenes promoted by PdCl2-AgOTf-o-chloranil

Chem. Sci., 2013, 4,2369-2373
DOI: 10.1039/C3SC50585E, Edge Article

Takehisa Maekawa, Yasutomo Segawa, Kenichiro Itami
A novel catalytic C-H activation route to privileged dibenzo[a,e]pentalene structures has been established.
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Copper(I)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

Chem. Sci., 2013, 4,2478-2482
DOI: 10.1039/C3SC50582K, Edge Article

Deng-Fu Lu, Cheng-Liang Zhu, Hao Xu
We describe a copper(I)-catalyzed diastereoselective diene hydroxytrifluoromethylation accelerated by bulky phosphine ligands, which delivers a variety of trifluoromethylated allylic alcohols.
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A radical-based approach for the construction of the tetracyclic structure of resiniferatoxin

Chem. Sci., 2013, 4,2364-2368
DOI: 10.1039/C3SC50329A, Edge Article

Koichi Murai, Shun-ichiroh Katoh, Daisuke Urabe, Masayuki Inoue
A novel radical-based strategy enabled the five-step construction of the unique tetracyclic skeleton of resiniferatoxin from the simple three components.
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Stiffness versus architecture of single helical polyisocyanopeptides

Chem. Sci., 2013, 4,2357-2363
DOI: 10.1039/C3SC50552A, Edge Article

Arend M. van Buul, Erik Schwartz, Patrick Brocorens, Matthieu Koepf, David Beljonne, Jan C. Maan, Peter C. M. Christianen, Paul H. J. Kouwer, Roeland J. M. Nolte, Hans Engelkamp, Kerstin Blank, Alan E. Rowan
Single molecule force spectroscopy reveals an unprecedented large heterogeneity in the stiffness of polyisocyanodipeptides.
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Reduced and quenched polarizabilities of interior atoms in molecules

Chem. Sci., 2013, 4,2349-2356
DOI: 10.1039/C3SC50242B, Edge Article

Aleksandr V. Marenich, Christopher J. Cramer, Donald G. Truhlar
Polarizability is a key molecular property controlling induction and dispersion forces in molecules, and atomic polarizabilities in molecules are widely used elements both in qualitative schemes for understanding molecular interactions and in quantitative methods for modeling them.
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Emission wavelength variation with changes in excitation in a Re(I)-bisthiazole ligand complex that breaks the Kasha-Vavilov rule

Chem. Sci., 2013, 4,2490-2495
DOI: 10.1039/C3SC22070B, Edge Article

Kelly E. Henry, Rebeca G. Balasingham, Anthony R. Vortherms, James A. Platts, John F. Valliant, Michael P. Coogan, Jon Zubieta, Robert P. Doyle
Photoinduced isomerism of the thiazolate ligand leads to the breaking of the Kasha-Vavilov rule. Variable emission upon changes in excitation wavelength in a fac-Re(I)(CO)₃ complex.
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Electrical conductance study on 1,3-butadiyne-linked dinuclear ruthenium(II) complexes within single molecule break junctions

Chem. Sci., 2013, 4,2471-2477
DOI: 10.1039/C3SC50312G, Edge Article

Hui-Min Wen, Yang Yang, Xiao-Shun Zhou, Jun-Yang Liu, Dao-Bin Zhang, Zhao-Bin Chen, Jin-Yun Wang, Zhong-Ning Chen, Zhong-Qun Tian
Single molecule conductance studies on diruthenium(II) organometallic wires reveal a higher conductance and a weaker length dependence compared with oligo(phenylene-ethynylene) having comparable length.
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A robust protocol for Pd(II)-catalyzed C-3 arylation of (1H) indazoles and pyrazoles: total synthesis of nigellidine hydrobromide

Chem. Sci., 2013, 4,2374-2379
DOI: 10.1039/C3SC50184A, Edge Article

Mengchun Ye, Andrew J. F. Edmunds, James A. Morris, David Sale, Yejia Zhang, Jin-Quan Yu
A robust C-3 arylation of indazole is developed and applied to the first total synthesis of nigellidine hydrobromide.
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Direct hydroxylation of primary carbons in small alkanes by wild-type cytochrome P450BM3 containing perfluorocarboxylic acids as decoy molecules

Chem. Sci., 2013, 4,2344-2348
DOI: 10.1039/C3SC50378J, Edge Article

Norifumi Kawakami, Osami Shoji, Yoshihito Watanabe
Primary carbons of propane and ethane are hydroxylated under high-pressure conditions of the alkanes (0.5 MPa) by wild-type P450BM3.
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Aminocatalytic remote functionalization strategies

Chem. Sci., 2013, 4,2287-2300
DOI: 10.1039/C3SC50405K, Perspective

Hao Jiang, Lukasz Albrecht, Karl Anker Jorgensen
The recent development in organocatalytic remote functionalization strategies will be outlined.
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Spin crossover or intra-molecular electron transfer in a cyanido-bridged Fe/Co dinuclear dumbbell: a matter of state

Chem. Sci., 2013, 4,2463-2470
DOI: 10.1039/C3SC22069A, Edge Article

Ie-Rang Jeon, Sergiu Calancea, Anangamohan Panja, Dalice M. Pinero Cruz, Evangelia S. Koumousi, Pierre Dechambenoit, Claude Coulon, Alain Wattiaux, Patrick Rosa, Corine Mathoniere, Rodolphe Clerac
A dinuclear cyanido-bridged Fe/Co molecular complex exhibits an unprecedented temperature induced spin crossover in the solid state and an intramolecular electron transfer assisted by controlled protonation in solution.
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Electrochemical water splitting by gold: evidence for an oxide decomposition mechanism

Chem. Sci., 2013, 4,2334-2343
DOI: 10.1039/C3SC50301A, Edge Article

Oscar Diaz-Morales, Federico Calle-Vallejo, Casper de Munck, Marc T. M. Koper
The electrocatalytic oxygen evolution reaction on gold electrodes follows a pathway in which oxygen evolves through an oxide decomposition or oxide disproportionation mechanism.
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Chlorination as a useful method to modulate conjugated polymers: balanced and ambient-stable ambipolar high-performance field-effect transistors and inverters based on chlorinated isoindigo polymers

Chem. Sci., 2013, 4,2447-2452
DOI: 10.1039/C3SC50245G, Edge Article

Ting Lei, Jin-Hu Dou, Zhi-Jun Ma, Chen-Jiang Liu, Jie-Yu Wang, Jian Pei
Balanced and ambient-stable carrier transport is achieved for the first time in polymer field-effect transistors.
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Stabilizing unstable species through single-site isolation: a catalytically active TaV trialkyl in a porous organic polymer

Chem. Sci., 2013, 4,2483-2489
DOI: 10.1039/C3SC22268C, Edge Article

Kristine K. Tanabe, Nathan A. Siladke, Erin M. Broderick, Takeshi Kobayashi, Jennifer F. Goldston, Mitchell H. Weston, Omar K. Farha, Joseph T. Hupp, Marek Pruski, Elizabeth A. Mader, Marc J. A. Johnson, SonBinh T. Nguyen
A catechol-functionalized porous organic polymer (POP) has been successfully metallated with a Ta^V trialkyl and remains thermally and structurally robust.
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The role of organometallic copper(III) complexes in homogeneous catalysis

Chem. Sci., 2013, 4,2301-2318
DOI: 10.1039/C3SC21818J, Perspective

Alicia Casitas, Xavi Ribas
The implication of organometallic copper(III) species as key intermediates for important copper-catalyzed reactions is highlighted. These reactions include nucleophilic organocuprate chemistry for C-C bond formation, C-heteroatom cross-coupling reactions (Ullmann condensation reactions and halide-exchange processes) and direct C-H bond functionalizations catalyzed by copper.
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Photochemical properties of Spinach and its use in selective imaging

Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC50729G, Edge Article

Pengcheng Wang, Jerome Querard, Sylvie Maurin, Sarang S. Nath, Thomas Le Saux, Arnaud Gautier, Ludovic Jullien
The Spinach fluorescent turn-on probe for RNA imaging exhibits photochemical behavior involving non-covalent binding and photoisomerization of both fluorogen stereoisomers.
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