RSC - Chem. Sci. latest articles

Radical-to-radical push–pull effect enhances single-molecule conductance in asymmetric diradicals

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00562D, Edge Article

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Dacheng Dai, Qian Zhan, Tianfang Shi, Xiaodong Liu, Lichuan Chen, Sergio Moles Quintero, Dongsheng Wang, Juan Casado, Yonghao Zheng
Asymmetry produces a unique modulation of diradical character through the appearance of a push–pull electron spin effect.
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Reversible iodine capture by nonporous adaptive hybrid[3]arene crystals

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00236F, Edge Article

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Ruike Zhang, Wenqian Liu, Jiong Zhou
Iodine capture is of great importance for environmental protection and chemical safety, motivating the development of efficient materials for iodine adsorption. Herein, we report an adsorption strategy that uses nonporous...
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Chiral communication in polymer systems: Generation and regulation of asymmetric structures

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01021K, Perspective

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Zixiang He, Gong Zhang, Wei Zhang
Chiral communication represents a fundamental characteristic of living systems and serves as a critical bridge linking molecular chirality with the macroscopic properties of chiral materials. In chiral polymer systems, chiral...
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Linear and branched supramolecular polymers formed from isomeric monomers as revealed by solution viscoelasticity

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC09763K, Edge Article

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Yufuka Furukawa, Ren Sato, Natsumi FUKAYA, Takashi Kajitani, Takuya Katashima, Kazunori Sugiyasu
Supramolecular polymers (SPs) assembled through non-covalent interactions provide a promising platform for designing soft materials with dynamic and tunable properties. However, the viscoelastic properties of their solutions remain poorly understood,...
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Chirality Induced Long-Range Spin-Selective Transport in Helical 3D Metal-Organic Frameworks

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01358A, Edge Article

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Amit Kumar Mondal, Pravesh Singh Bisht, Rabia Garg, Tapan Kumar Das, Nidhi Bhatt, Subash Chandra Sahoo
The exploration of novel chiral molecules as efficient spin-filtering materials via chirality induced spin selectivity (CISS) effect remains an active and evolving area of research within the field of chiral...
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Linker desymmetrisation directs low-polar cages in an anion-pillared MOF for acetylene and ethylene purification from ternary mixtures

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00819D, Edge Article

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Jun-Jie Wu, Peng-Dan Zhang, Xue-Qian Wu, Shuai-Hao Huang, Wen-Wen Dong, Ya-Pan Wu, Dong-Sheng Li
A unique SiF₆²⁻-pillared MOF, featuring low-polar cage surfaces and multiple binding sites, has been successfully constructed via linker desymmetrisation, which exhibited impressive C₂H₂ and C₂H₄ purification performances from ternary mixtures.
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Engineering porous organic polymers for enhanced CO2 capture: from synthesis to implementation

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00384B, Review Article

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Mohammed G. Kotp, Shiao-Wei Kuo
The escalating concentration of atmospheric carbon dioxide (CO₂) necessitates the development of efficient and scalable carbon capture technologies.
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Deciphering the stimuli-responsive behavior of TPPE-incorporated flexible metal–organic frameworks

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09651K, Edge Article

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You Fan, Zhikai Zhu, Shuo Zhou, Federico Gorelli, Yuchen Ye, Huixin Hu, Shenghan Zhang, Hongliang Dong, Changzhong Liao, Ziyou Zhang, Zhiqiang Chen
Pressure-induced conformational rearrangement in a TPPE-based flexible MOF can be locked by the framework, enabling the high-pressure emissive phase to be captured at ambient conditions.
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ProCharTSPTM label-free optical detection of protein acetylation using UV-vis charge transfer spectra

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09293K, Edge Article

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Himanshi Maniram Devi, Apoorva Badaya, Arijit Maity, Simangka Bor Saikia, Ravindra Venkatramani, Rajaram Swaminathan
We report the first spectroscopic detection of protein acetylation in solution using UV-vis Protein Charge Transfer Spectra (ProCharTS).
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Conversion of trifluoromethyls into esters along with polyether upcycling via cation-transfer-catalyzed C–O/C–F metathesis

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC10208A, Edge Article

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Zhuojun Li, Xiangqian Shi, Dongke Zhang, Qian Wu
Herein report a silylium ion-catalyzed C–F/C–O metathesis applicable to polyethers and polyfluoroalkanes. A cation transfer mechanism is proposed, with silyloxonium and Meerwein-type salts as key intermediates.
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Controlling triplet-pair formation in acene-bridged trimers through locally excited–charge-transfer state mixing

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00278A, Edge Article

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Ebin Sebastian, Daniel G. Congrave, Jeroen Royakkers, Stephanie Montanaro, Huaxi Huang, Ashish Sharma, Julia Osmólska, He Zhu, Chanakarn Phansa, Jurjen Winkel, Oliver Millington, Murad J. Y. Tayebjee, Luis M. Campos, Hugo Bronstein, Akshay Rao
Bridge–chromophore resonance governs intramolecular singlet fission: weak LE–CT mixing enables correlated triplet pair (¹TT) formation, while strong LE–CT mixing redirects S₁ into an exciplex, suppressing singlet fission.
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Aluminylation: a generalizable route towards low-valent aluminum under moderate conditions with controlled product nuclearity through precursor design

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02187E, Edge Article

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Paris C. Reuel, Yogesh Shandilya, M. Talha Wattoo, Alison B. Altman
Aluminylation enables redox-neutral access to low-valent aluminum complexes with nuclearity and heterolepticity tunable by substrate identity and Al(I) speciation.
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A Dual-Responsive Cationic Acridinium Nanohoop: Redox Activity and Acid/Base-Controlled Reversible Guest Capture and Release

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01132B, Edge Article

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Jiao Ming, Jin Zhang, Yan Hu, Kai Lan, Dongmei Zhang, Ping Li, Jiarong Miao, Jiyong Jiang, Xiaobo Zhang, Hanchi Zhong, Peiyuan Yu, Chuyang Cheng
In this work, we report a fully conjugated, radially cationic nitrogen-doped cycloparaphenylene derivative, Ad[10]CPP+, constructed using the acridinium moiety as a functional building block. This compound exhibits remarkable reversibility in...
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Picolinate-based acyclic ligand for rare earth element extraction and separation

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00975A, Edge Article

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Yangyang Gao, Sean Medin, Alexa M. Schmitz, Justin J. Wilson
An acyclic chelator was investigated for its ability to selectively dissolve and directly separate mixed rare earth element oxalates and electronic waste.
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Molecular jackhammers induce intracellular calcium release and skeletal muscle contraction by vibronic-driven action

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09717G, Edge Article

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Yuchen Rui, Bowen Li, Vardan Vardanyan, Soonyoung Kim, Dallin Arnold, Jacob L. Beckham, Ciceron Ayala-Orozco, Ana L. Santos, Gautam Chaudhry, Lixin Zhou, Shichen Xu, Tengda Si, Zicheng Wang, Angel A. Martí, Anatoly Kolomeisky, Jacob T. Robinson, James M. Tour
We showed that near-infrared light-activated small-molecule mechanical stimulation can precisely trigger intracellular calcium release, inducing muscle cell contraction and in vivo responses in Hydra, enabling versatile remote mechanoregulation.
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Ultralong Organic Room-Temperature Phosphorescence of Tetraphenylene via Lactose Functionalization and Chromophore Isolation

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01359G, Edge Article

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Xin Niu, Mingxing Chen, Yuan Zhang, Guang-Jian Liu, Su-Hang Qian, Hui Zhang, Jia-Qing Jiang, Hongwei Tan, Guo-Wen Xing
Achieving efficient and ultralong room-temperature phosphorescence (RTP) in purely organic systems is challenging. This work addresses this issue by unlocking unprecedented RTP performance in nonplanar tetraphenylene (TeP), a chromophore traditionally...
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Fast Hydrated-Ion Transport and Desolvation in Pyridinyl COF Membranes via Competitive Coordination

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01290F, Edge Article

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Xuan Li, Jiaxin Liu, Yilin Zhang, Zhixiang Dai, Zihan Tan, Hongli Yang, Chao Xu, Maria Strømme, Shengyang Zhou, Zhong-Ming Li
Hydrated-ion transport and desolvation dominate energy transfer and ionic selectivity in membrane separation, electrochemical energy storage, and catalytic systems, whereas achieving fast ion conduction with low hydration remains highly challenging.In...
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A photocleavable peptidic Ru(II) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00953K, Edge Article

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Mihyun Park, Juliana Gonçalves, Sandra Deiser, Sebastian Fenzl, Felix Alexander Böhm, Katja Steiger, Susanne Kossatz, Nicole Strittmatter, Angela Casini
Mass spectrometry imaging (MSI) is a versatile technique for spatially resolved multi-omics analysis in clinical research. However, its proteomic applications remain constrained by issues such as poor ionisation efficiency and...
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Inducing configurational stability in inherently flexible expanded heterohelicenes and unlocking stimuli-responsive chiroptical switching

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02610A, Edge Article

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Manisha Pal, Pirudhan Karak, Debranjan Hati, Mrityunjay Giri, Subi J. George, Joyanta Choudhury
“π-Expanded” (hetero)helicenes attracted special attention by virtue of their increased helical diameter, enlarged cavity, structural flexibility, and dynamics. However, their structural flexibility results in low enantiomerization barriers (ΔGe‡ <20 kcal·mol−1),...
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Regulating KBBF-like structures via a charge-assisted hydrogen-bonded framework to enable easily grown ultraviolet nonlinear optical crystals

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09306F, Edge Article

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Mingshu Zhang, Shuya Zhao, Zhen-Cheng Wu, Yue Yin, Zheyu Zhang, Jiafeng Chen, Sheng-Ping Guo, Yan Zhou
We regulate KBBF-type structures via a 3D charge-assisted H-bonded framework, yielding a new UV-NLO crystal SAN with strong SHG response and large birefringence, and easy growth of centimetre-scale crystals from room-temperature solution.
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Lithium-Selective Supramolecular Assembly and Capture by Tripeptide Gelators

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01183G, Edge Article

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Dipankar Ghosh, Ralf Schweins, Andrew J Smith, Dave Adams
We report a simple design strategy to introduce lithium-responsiveness into N-capped peptide low-molecular-weight gelators by incorporating the FFD tripeptide motif (FF extended with Asp). Asp adds an oxygen-rich carboxylate residue...
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Regulation of Local Chemistry in O3-type Layered Oxide Cathodes for Practical Sodium-Ion Batteries

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01783E, Edge Article

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Tongtong Huo, Qian Yang, Genliang Yu, Mingyue Li, Xuejie Bai, Ting Lv, Xiaobo Zhang, Jie Xu, kai Liu, Xunzhu Zhou, Xin Tan, Lin Li, Kaixiang Lei, Shijian Zheng
O3-type layered oxide cathodes have emerged as promising candidates for advanced sodium-ion batteries (SIBs) due to their high theoretical specific capacity. However, undesirable phase transitions, irreversible O2 release, and transition...
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Retraction: Ligand assisted Co(II) catalyzed direct C–H alkylation of aryl ketones with diverse alkyl halides

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC90080A, Retraction

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Aniket Nigade, Saurabh Vinod Parmar, Vidya Avasare
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Synergistic Cu nanoparticles and Cu single atoms leveraging hydrogen spillover for selective CO electroreduction to acetate

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC02439D, Edge Article

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Qinglong Wang, Tianfu Liu, Xinhui Guo, Pengfei Wei, Dunfeng Gao, Guoxiong Wang, Xinhe Bao
The hydrogen spillover from Cu single atoms breaks the kinetic trade-off between CO adsorption and hydrogen supply on Cu nanoparticles, resulting in selective CO electroreduction to acetate with an impressive faradaic efficiency of 60.6%.
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Flexible dimethylsilylene bridges in silicon quantum dot-anthracene adducts promote triplet energy transfer

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00926C, Edge Article

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Sina G. Lewis, Kefu Wang, Nhien Q. Nguyen, Aracely Gonzalez, Honghao Wang, Timothy C. Siu, Lorenzo Mangolini, Sean T. Roberts, Timothy A. Su, Joel David Eaves, Ming Lee Tang
Triplet energy transfer (TET) between photoexcited Si QD donors and anthracene acceptors is enhanced by the flexibility of longer dimethylsilylene bridges that allow through-space interactions.
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Design of permeability-optimized target-binding macrocycles via direct preference optimization

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01722C, Edge Article

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Heqi Sun, Hong Tan, Yanyi Chu, Jiayi Li, Ruixuan Wang, Dong-Qing Wei
CycDiff-DPO uses preference-aligned diffusion to design target-specific macrocyclic peptides with enhanced membrane permeability, balancing binding competence and cell permeability in one framework.
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Pd-N-C shelled Pd nanoparticle catalysts for high-performance hydrogen peroxide electrosynthesis

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09543C, Edge Article

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Jiao Dong, Zixiang Su, Yanyan Jia, Runjia Xing, Sixuan She, Daqin Guan, Sheng Dai, Jinling Wang, Manqing Chai, Zhenshan Hou, Zhi-Qiang Wang, Hehe Wei, P. Hu, Xue-Qing Gong
A PdSAN_2-2C structure with balanced pyridinic/pyrrolic nitrogen enhances OOH adsorption for H₂O₂ production in the oxygen reduction reaction. The derived Pd@PdSAN_2-2C core–shell catalyst achieves 97% H₂O₂ selectivity and high yield at 200 mA cm⁻².
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ZrO2-induced d–d spatial coordination effects of Ru single-atom catalysts to boost the oxygen evolution reaction

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01575A, Edge Article

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Dandan Yu, Bin Liu, Dongming Li, Junkai Yu, Xijie Lan, Shuhong Liu, Zhuxin Li, Pengyun Gao, Yong Zhang, Hong Zhao
ZrO₂-induced d–dspatial coordination tailors the electronic structure of Ru single atoms, achieving ultralow overpotential (208 mV) and 500-hour stability for acidic oxygen evolution.
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Core–wing modulated squaraines with enhanced two-photon absorption and efficient photothermal eradication of bacteria

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00573J, Edge Article

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Xin-Ao Liu, Xingtong Zhou, Tong Zhang, Congdi Shang, Liping Ding, Taihong Liu, Yu Fang
Core–wing modification effect on the photophysical properties and excited-state dynamics of squaraines are investigated. Effective fluorescence bioimaging of onion cells and photothermal antibacterial activity against E. coli are evaluated.
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Machine learning potential for modelling dynamic hydrogen bond networks in MOF MIL-120

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09058J, Edge Article

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Xin Jin, Yutao Li, Kelian Gaedecke, Xiaoqi Zhang, Berend Smit
Metal–organic frameworks (MOFs) are porous materials with the potential for gas adsorption. This work presents a generalizable framework for simulating adsorption in flexible MOFs using machine learning potentials.
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Dimerisation of aryl-substituted bicyclobutanes (BCBs): revealing a new mode of 1,3-dipolar background reactivity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01258B, Edge Article

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Malini George, Daniil A. Knyazev, Kamil Swiatek, Heinrich F. von Köller, Daniel B. Werz
We present a detailed investigation of dimerisation reactions involving bicyclo[1.1.0]butanes (BCBs), catalysed or mediated by Lewis or Brønsted acids.
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Geometric orthogonality as a recipe for efficient intramolecular charge generation in core substituted NDI derivatives

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00456C, Edge Article

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Hugh C. Britton, Alberto M. Santa Daría, Chao Lyu, Andras B. Augusztin, Lewis M. Cowen, Dejan-Krešimir Bučar, Alethea B. Tabor, Bob C. Schroeder, Sandra Gómez, Jose M. Marin-Beloqui
Herein, we analyse the excited state dynamics of NDI derivatives with increasing orthogonality due to steric hindrance. Spectroscopy and theoretical calculations show an increase in the charge generation and lifetimes with larger orthogonality.
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Influence of molecular shape and hydrogen bonding on glycolipid self-assembly into thermotropic gyroid phases

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00024J, Edge Article

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Soumi Das, Caini Zheng, Timothy P. Lodge, J. Ilja Siepmann, Michelle A. Calabrese, Theresa M. Reineke
Thermotropic double gyroid formation and stability in glycolipids critically depends on molecular shape and hydrogen bonding.
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Non-Ideal Stoichiometry and Thermochemistry of Aqueous Iridium Oxide Nanoparticles in Proton-Coupled Electron Transfer and Oxygen-Atom Transfer

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00492J, Edge Article

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Justin L. Lee, Saeed Saeed, James M Mayer
Reported here are reactions of aqueous colloidal IrOx nanoparticles (NPs) with proton-coupled electron transfer (PCET) and oxygen-atom transfer (OAT) organic reagents, determining the reaction stoichiometries and thermochemistry. IrOx have attracted...
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Synthesis of bacteriochlorophyll a

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC10233B, Edge Article

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Duy T. M. Chung, Khiem Chau Nguyen, Yizhou Liu, Jonathan S. Lindsey
A modular synthesis of the photosynthetic macrocycle BChl a proceeds from simple starting materials. The stereochemistry of the vicinal substituents in the pyrroline rings was set via early-stage precursors.
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Individually addressable multichannel nanoelectrodes reveal spatially resolved functional heterogeneity of vesicles in single cells

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01178K, Edge Article

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Chuchu Xu, Ruolin Liu, Yuhao Zheng, Yue Chen, Irina Svir, Alexander Oleinick, Zhongqun Tian, Christian Amatore, Keke Hu
A multichannel nanoelectrode platform enables parallel, independent nanoscale measurements, revealing subcellular heterogeneity in vesicle density, content, and release behavior within single cells.
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Instability of PCN-224(Fe) during the Oxygen Reduction Reaction; Metal-Organic Framework Electrocatalysts may have an Achilles heel

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01428C, Edge Article

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Dana Rademaker, Roy Maas, Stefania Tanase, Hongrui Kang, Jan Philipp Hofmann, Dennis Hetterscheid
Incorporation of catalytic sites within metal-organic frameworks has been considered advantageous as the amount of catalytic sites per cm 2 electrode surface and be greatly expanded, while simultaneously the stability...
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Visible-Light-Induced Chlorine Photoelimination from Acridinium-Phosphine Gold(III) Complexes

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01586G, Edge Article

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Shantabh Bedajna, Kristopher G Reynolds, Mohammadjavad Karimi, Elishua Litle, Daniel G. Nocera, François P. Gabbaï
With the objective of developing transition metal complexes that undergo visible-light-induced halogen photoelemination, we have successfully synthesized trivalent gold trichloride complexes featuring an acridinium unit. Photoexcitation of the acridinium π+...
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Asymmetric electronic modulation in bridged Cu-O-Ni dual-atom catalysts promoting CO2 electroreduction

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01508E, Edge Article

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Xue Bai, Li-Yuan Xiao, Xiaoqin Xu, Anaer Husile, Fu-Quan Bai, Lina Li, Jingqi Guan
Atomically precise heteronuclear dual-site configuration provides an effective strategy to overcome the intrinsic activity and selectivity limitations of single-atom systems in electrochemical CO2 reduction (CO2RR). Here, we introduce an oxygen-bridged...
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Black-box data: a new paradigm for biomedicine in the AI era

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01189F, Perspective

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Luca Naef, Michael Bronstein
“Black-box” data sources prioritize machine learning consumption by moving away from tradeoffs optimized for human-centric consumption, yielding orders of magnitude higher throughput. Our paper outlines seven design strategies to achieve this.
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High energy density quasi-solid-state lithium batteries using in situ polymerized gel electrolytes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01543C, Review Article

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Zehui Fan, Yingxin Liu, Lanhua Ma, Hang Liu, Qinghao Chen, Yi Wang, Ewa Zygadło-Monikowska, Yunhua Xu
This review provides an overview of recent progress in high energy density quasi-solid-state lithium batteries using in situ polymerized gel electrolytes. It also discusses the future perspectives and potential avenues for development in this field.
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Salicylhydroxamic acid as an electro-responsive and switchable adhesive molecule

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC07881D, Edge Article

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Kan Wang, Vedika Khare, Abhilash Arjan Das, Fatemeh Razaviamri, Bruce P. Lee
Salicylhydroxamic acid exhibits electro-responsiveness and switchable interfacial bonding to metallic surfaces under wet conditions without the need for protecting groups.
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Bridging Lewis Acidic Antimony Centers with Electron-Withdrawing Carborane Cages

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00316H, Edge Article

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Victoria P Rubio, Mckinley H Durham, Matthew Scurria, Tyler A Kerr, Osvaldo Gutierrez, Alex Spokoyny
While fluorinated carbon-based electron withdrawing substituent groups are commonly used by practitioners when strengthening the Lewis acidity of group 15 organometallic compounds, we exploit an alternative approach by leveraging the...
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Design Rules for Ternary CO 2 Hydrogenation Catalysts via Literature-Sourced Network Construction and Analysis

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00563B, Edge Article

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Yoshiki Hasukawa, Fernando Garcia Escober, Shun Nishimura, Keisuke Takahashi, Lauren Takahashi
The development of CO 2 hydrogenation catalysts has largely depended on researchers's trial and error efforts. However, exploring unreported ternary catalysts requires substantial time and cost, highlighting the need for...
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A novel lactam-based AIE building block for high-performance deep-blue electroluminescent materials

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00940A, Edge Article

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Luyao Liu, Jingli Lou, Jiaxing Wan, Yin Li, Hao Xiong, Yu Huang, Dezhi Yang, Han Zhang, Ben Zhong Tang, Zhiming Wang
A novel building block PADP was efficiently designed and synthesized based on a multirotor lactam framework, and its derivative PADP-TPA exhibits state-of-the-art electroluminescent performance among deep-blue AIE fluorescent materials for OLEDs.
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The Acylative Kinetic Resolution of 1,2-Azaborine Naphthols

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC02046A, Edge Article

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Martha I Prindl, Aidan P. McKay, David Bradford Cordes, Andrew D. Smith
The enantioselective synthesis of atropisomeric molecules containing stereogenic axes is becoming increasingly important due to their growing incorporation within medicinally relevant compounds. Organocatalytic routes to selectively prepare highly enantioenriched stereogenic...
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PANDA: AND Logic-Gated RNA Sensing Enabled by Photo-Activated RCA-Argonaute Cascade

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00827E, Edge Article

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Xinxin Ke, Heming Fan, Jingwen Qu, Junlan Wang, Yilong Wang, Tengfei Xu, Chuanxia Chen, Chunyi Hu, Tao Hu
Achieving stable, multiplexed, and affordable nucleic acid detection in a true one-pot format remains a long-standing challenge for molecular diagnostics. Here, we report PANDA, a photo-activated rolling circle amplification (RCA)-Argonaute...
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Pyroglutamate pendant block copolymers: evolution of inverse and conventional morphologies from RAFT-mediated PISA

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01206J, Edge Article

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Pampa Chowdhury, Kamal Bauri, Priyadarsi De
By emulating the complex hierarchical assemblies found in bio-derived materials, nanostructural synthetic designs expand material properties and enlarge their capability for versatile applications. Correspondingly, polymerization-induced selfassembly (PISA) emerges as a...
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Stretchable cyclodextrin slide-ring copolymer self-generating hydrogels for high-performance flexible electronics

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00045B, Edge Article

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Xu Pan, Bo Wang, Xiao-Yong Yu, Jin-Long Yue, Xu Zhang, Chen Zhang, Ying-Ming Zhang, Yong Chen, Yu Liu
A slide-ring hydrogel was synthesized from AM, AA, PEDOT:PSS, and a low-coverage cyclodextrin polyrotaxane crosslinker, whose tensile strain was greatly enhanced. The hydrogel enabled dual-modal flexible wearable sensors for joint movement.
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Origins of the Selectivity of Late Transition Metals of Group 9 and Group 10 for Oxidative Addition of C–H vs C–Cl Bonds

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00090H, Edge Article

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Yehao Qiu, Alistair J Sterling, Kevin K Ikeda, Alexander Zech, Matthias Loipersberger, Diptarka Hait, Martin Head-Gordon, John F Hartwig
Oxidative addition of carbon–hydrogen or carbon–halogen bonds occurs in many reactions catalyzed by late transition-metal complexes. Metals of group 9 typically react with C–H bonds faster than C–X bonds, while...
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Comment on “Radical-mediated proton transfer enables hydroxyl radical formation in charge-delocalized water” by R. Zhao, Q. Zhang, N. Yang, L. Li, Z. Li and C. Cui, Chem. Sci., 2025, 16, 11954

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC05396J, Comment

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Willem H. Koppenol
Cui and coworkers claim that H₂O˙⁺ and HO˙ are formed spontaneously by lowering the pH to below 4. This is thermodynamically most unlikely. Thus, proton transfer does not involve HO˙.
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Recent Advances in Site-Specific Modifications of Peptides and Proteins

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC09331G, Review Article

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Xin-Rong Duan, Meng-Qian Zhang, Geng-Hui Feng, Yan-Mei Li
Modification at specific sites has long been a central goal in peptide and protein chemistry. Introducing functional groups at specific sites is an ideal state for protein function research and...
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Ammonia monooxygenase: a work in progress

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01048B, Review Article

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Thomas C. Arndt, Alexander L. Laughlin, Kyle M. Lancaster
Ammonia monooxygenase (AMO) is a multimeric, multidomain integral membrane protein belonging to the copper membrane monooxygenase (CuMMO) family. This globally proliferated enzyme initiates nitrification in both archaea and bacteria.
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Electrochemical Functionalization of Pyridines

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00233A, Review Article

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Satabdi Bera, Tushar Singha, Nakul Abhay Bapat, Durga Prasad Hari
Pyridines are important nitrogen-containing heteroaromatics with wide applications in pharmaceuticals, agrochemicals, ligands, and materials science. However, their selective C–H functionalization remains challenging due to low nucleophilicity, regioselectivity issues, and catalyst...
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Solvent–temperature coupled hydride transfer controls product selectivity in the HSiR3/KOtBu catalytic system

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00107F, Edge Article

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Haojiang Yao, Zhenhao Zhou, Ye Liu, Dong H. Zhang, Guohui Li
The HSiR₃/KO^tBu catalytic system affords a notable regioselective C–H silylation reaction using alkaline earth metals, yet its mechanistic origins and the temperature-dependent selectivity inversion remain unresolved.
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Correction: Regulating red-shifted phosphorescence of carbon dots via introducing magnesium chloride

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC90074G, Correction

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Yibin Long, Haoda Zhang, Yongjin Chen, Xiaoming Yang
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Regenerating spent LiFePO4 with tailored molecular groups: from bulk lattice repair to surface conductive coating for enhanced cycling stability

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01492E, Edge Article

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Yi Chen, Xizhuo Chen, Zihao Zeng, Wei Sun, Yue Yang, Peng Ge
Regeneration of spent LiFePO₄ was achieved by bulk lattice repairing and surface conductive coating, delivering 95.7% capacity retention after 500 cycles at 1.0C and 92.2% after 1000 cycles at 5.0C.
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Stepwise BN bond cleavage by isocyanides: access to the 3-azaborole structural motif

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01836J, Edge Article

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Libo Xiang, Ka Ho Kwan, Yi Jing, Junyi Wang, Alexander Matler, Xuenian Chen, Zhenyang Lin, Qing Ye
The BN bond undergoes a [2+1+1] cycloaddition with two equiv of isocyanide, followed by reductive insertion of a third isocyanide into the BN bond, affording a 3-azaborolediide with pronounced charge delocalization onto the o-carborane framework.
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Reductive-defect-suppressed titanium oxynitrides via Ca3N2-assisted topochemical nitridation

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00009F, Edge Article

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Yuki Sasahara, Kento Yoshii, Daichi Kato, Issei Yamamoto, Yusuke Tsutsui, Kei Morisato, Hikaru Takeuchi, Tatsuya Tsumori, Hiroshi Takatsu, Satoshi Horike, Shu Seki, Kazuhiko Maeda, Hiroshi Kageyama
One-step, ammonia-free topochemical nitridation using Ca₃N₂ enables 3O²⁻/2N³⁻ anion exchange from BaTiO₃ while suppressing Ti³⁺-related reductive defects, yielding bright-orange oxynitrides.
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Selective White Phosphorus Activation and Functionalization with Inorganic Grignard Reagents

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC01229A, Edge Article

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Franziska Gilch, Jan Brossette, Franz F. Westermair, Wagner Silva, Gábor Balázs, Ruth M. Gschwind, Hendrik Zipse, Robert Wolf
We describe the targeted and selective functionalization of white phosphorus (P4) using ‘inorganic Grignard reagents’. Reactions of the Fe-Mg complexes [(DippBDI)Mg(THF)xFp] (Fp = CpFe(CO)2, 1: x = 0; 1 THF:...
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Synthesizability via reward engineering: expanding generative molecular design into synthetic space

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09263A, Edge Article

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Dominik Dekleva, Alexey Voronov, Jon Paul Janet, Albin Ekborg, Jure Borišek, Martina H. Rambaher, Hannes H. Loeffler
SynthSense couples generative molecular AI with retrosynthetic reward functions to produce novel, drug-like molecules that are not only feasible to synthesize but aligned with the parallel synthesis workflows of modern medicinal chemistry.
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Charge-Dependent Modulation of S–H vs O–H Excited-State Intramolecular Proton Transfer

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC10166B, Edge Article

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Chi-Chi Wu, Hao-Cheng Tsai, Hau-Yu Liu, Ya-Chen Lin, Chih-Hsing Wang, Alexander P. Demchenko, CHAO-TSEN CHEN, Pi-Tai Chou
Substituent effects critically influence electronic coupling and proton-transfer dynamics in excited-state intramolecular proton transfer (ESIPT), yet a quantitative link between charge redistribution and ESIPT behavior remains elusive. Here, we employ...
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Alkali metal cation effects for rapid C–H activation by iron(0) complexes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01470D, Edge Article

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Nereida Hidalgo, Kendal W. Southwell, Ryan S. Donnelly, Brandon Q. Mercado, Sebastian M. Krajewski, Xiaoping Wang, Patrick L. Holland
Ion pairing with alkali metal cations offers a novel way to enhance the rate of C–H activation.
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Photocrosslinking chemistry for direct photopatterning of colloidal nanocrystals: toward pixelated light emitting diodes and beyond

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC10169G, Review Article

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Wenyue Qing, Hao Zhang
This review summarizes photocrosslinking-enabled direct photopatterning of QDs, elucidating molecular design, mechanisms, and applications in high-performance QLEDs, extensions to other nanomaterials, and 3D printing.
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Quantum coherence enhancement through control of metal–ligand covalency: modulating spin–orbit coupling in isostructural molecular qubits

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09844K, Edge Article

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Subrata Ghosh, Paul H. Oyala, Maksym Fizer, Vsevolod D. Dergachev, Sergey A. Varganov, Natia L. Frank
Higher metal-ligand covalency in 1-Cu reduces effective spin-orbit coupling, extending the spin-relaxation and coherence times – a key strategy for tuning quantum coherence in molecular spin qubits.
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Spin effect regulation as a design principle for M–N–C catalysts for oxygen electrocatalysis

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00439C, Edge Article

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Haiyan Li, Zhanzhao Fu, Yuan Yuan, Di Zhang, Yubo Chen, Hao Li, Ang Cao
Recent advances indicate that regulating the spin state of metal centers can markedly modulate catalytic performance, motivating interest in exploiting spin effects for the design of highly efficient oxygen electrocatalysts.
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Atomic-level engineering of single-atom catalysts for selective C–C coupling in CO2 hydrogenation to ethanol

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01691J, Review Article

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Wenyu Zheng, Yiming Liu, Xiaohai Zhang, Shengjie Bai, Aobing Li, Kelun Jiang, Feng Wang, Ya Liu, Yubin Chen, Shaohua Shen
This review explores single-atom catalysts for CO₂-to-ethanol conversion, focusing on atomic-level design principles that enhance C–C coupling selectivity and activity to enable sustainable carbon utilization and renewable fuel production.
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Ultrasmooth and thin pheomelanin-like film as a metal-free electrocatalytic enhancer

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00776G, Edge Article

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Chan Yeon Kim, Jae Ryeol Jeong, Seong Ah Jo, Jun Seok Park, Joowon Choi, Myung Jun Kim, Minho Kim, Kyungtae Kang, Min Hyung Lee
Ultrasmooth and thin pheomelanin-like films are developed as metal-free electrocatalytic enhancers. These conformal organic coatings significantly improve OER performance on RuO₂ by optimizing interfacial charge-transfer kinetics.
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Change of the aromatic nature through face-to-face stacking

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC10179D, Edge Article

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Qian Wang, Rinat T. Nasibullin, Dage Sundholm
Antiaromatic porphyrinoid rings form stacked aromatic dimers with a delocalized double bond between each pair of the porphyrinoid rings.
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Recent advances in MOF-based single-atom photocatalysts for CO2 to solar fuel conversion under sunlight irradiation

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00691D, Review Article

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Adnan Majeed, Minh-Khoa Duong, Van-Duc Nguyen, Trong-On Do
Rationally designed MOF-based single-atom catalysts enable efficient and selective solar-to-fuel CO₂ conversion.
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Asymmetric hydrogenation of 3H-azepines via catalytic kinetic resolution: access to anti-disubstituted azepanes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01819J, Edge Article

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Linda Bui, Dilara Berna Yildiz, Diego García Matesanz, Esteban Matador, Raquel Sanchez, Iuliana Atodiresei, Giovanni Lonardi, Daniele Leonori
Azepanes are increasingly valued scaffolds in drug discovery, yet general asymmetric methods for their synthesis remain elusive. Herein, asymmetric hydrogenation of 3H-azepines affords anti-configured azepanes with excellent diastereo- and enantioselectivity.
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Dock & design: engineering specificity for an alternative pimaradiene outcome with the ent-kaurene synthase from Bradyrhizobium japonicum

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09199C, Edge Article

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Mark Schmidt-Dannert, Yue Zhang, Jin Liang, Qiang Wang, Samuel Tufts, Meirong Jia, Dean J. Tantillo, Justin B. Siegel, Reuben J. Peters
The complexity of the carbocation cascade reactions catalyzed by terpene synthases has hindered enzymatic engineering. Prospective application of the computationally inexpensive TerDockin approach enables rational design of product outcome.
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Photochemical skeletal editing: one-step transformation of diaryl dithiophenes into regiodefined helicenes

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01717G, Edge Article

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Xiaoli Shi, Ling Mei, Chenxi Dong, Chunmei Zhao, Chen Chen, Yimin Xu, Wan Xu, Chunli Li, Guangxia Wang, Zhiying Ma, Hua Wang
A novel photochemical skeletal editing strategy enables the efficient, regioselective one-step synthesis of diverse π-extended multiple [n]helicenes from diaryl dithiophenes under mild conditions with broad substrate scope.
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Recent advances in low-temperature ceramic fuel cells: material design and applications

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00598E, Review Article

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Ying Zhang, Rui Guo, Yu Shen, Tianmin He
Schematic diagram of ceramic fuel cells, functions of key materials and design methods.
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A high-affinity dopamine aptamer: implications of library diversity and negative selection

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09660J, Edge Article

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Yi Yu, Yuanli Li, Juewen Liu
Capture-SELEX and deep sequencing identified a sub-micromolar-affinity dopamine aptamer differing by one key nucleotide from the previously reported sequence, suggesting too stringent negative selections may eliminate higher-affinity aptamers.
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Unraveling the hidden conditions in NiOOH for electrocatalytic oxidation of methanol to formaldehyde with unity Faraday efficiency and selectivity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00905K, Edge Article

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Zixuan Ma, Yuling Yuan, Ze Lv, Yimeng Ma
This study reveals that the electrocatalytic oxidation of methanol to formaldehyde using NiOOH requires a low applied potential and high concentration of methanol, associated with the control of the 2nd C–H bond activation in the methanol molecule.
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Functional-oriented design of gradient composite fluoride interphase for enhanced silicon anode performance

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC01590E, Edge Article

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Yu Jing, Zhixing Wang, Huajun Guo, Xinhai Li, Hui Duan, Wenjie Peng, Guochun Yan, Guangchao Li, Jiexi Wang
Gradient interphase composed of crystalline Li₂SiF₆ and amorphous Li₃AlF₆ is successfully constructed on porous silicon via in situ fluorination strategy with high ionic conductivity, superior mechanical strength and effective electrolyte isolation.
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Molecular engineering of metalloporphyrins and phthalocyanines for homogeneous and heterogeneous CO2 electroreduction

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC07983G, Review Article

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Aakash Santra, Arnab Ghatak, Zhiyuan Chen, Jing Shen, Joost Helsen, Yuvraj Birdja, Ally Aukauloo, Chanjuan Zhang
This review summarizes advances in CO₂ electrocatalysis, from homogeneous to heterogeneous systems, with emphasis on hybrid molecular–metallic co-catalysts that drive improved activity, selectivity, and overall catalytic performance.
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Inch-sized Achiral Perovskite Ferroelectric Single Crystals for Multiaxial Passive Circularly Polarized Light Response

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC08521G, Edge Article

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Yueying Wang, Zeng-Kui Zhu, Yuhang Jiang, Jianbo Wu, Wenhui Wu, Haodong Ge, Yong Wang, Yao Li, Huawei Yang, Panpan Yu, Ying Zeng, Song Yang, Junhua Luo
In recent years, hybrid perovskite ferroelectrics with significant spontaneous polarization features have shown prominent advantages in passive circularly polarized light (CPL) detection. Nonetheless, the successful realization of multiaxial ferroelectric semiconductors...
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Orthogonal cation and anion template-directed synthesis of a heteroditopic [3]catenane for ion-pair recognition

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC05942A, Edge Article

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Hui Min Tay, Andrew Docker, Antonio J. Martínez-Martínez, Paul D. Beer
The first orthogonal template strategy for the synthesis of higher order interlocked structures is described. Orthogonal cation and anion templates were employed in a stepwise fashion to construct a hetero[3]catenane...
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Tuneable electronic coupling in linked bis(cubane) cobalt-oxo clusters

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09713D, Edge Article

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Vincent J. P. Maddi, T. Don Tilley
Dimeric complexes of cobalt-oxo cubane clusters relevant to water-oxidation are synthesized and demonstrated to possess inter-cluster electronic coupling via electrochemistry.
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A protein-based model of carbon monoxide dehydrogenase exhibits tunable covalency across cluster oxidation and ligand-bound states

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00023A, Edge Article

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Luke C. Lewis, Prajakta Badve, Itzel P Vaca, Pujan Ajmera, Yuri Lee, Anastassia Alexandrova, Katlyn Meier, Hannah S. Shafaat
The nickel-containing carbon monoxide dehydrogenase (CODH) uses a unique heterometallic [NiFe₄S₄] cluster active site, called the C-cluster, to catalyze the reversible reduction of carbon dioxide (CO₂) to carbon monoxide (CO)...
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Activation Volumes Associated with Excited-State Electron Transfer Across Amidinium‑Carboxylate Bridge

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00291A, Edge Article

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Daniel Langford, Rene Weiss, Marcel Krug, Maxence Urbani, Achim Zahl, Carolin Müller, Tim Clark, Tomás Torres, Dirk M. Guldi
Pressure was used to modulate interactions in an electron donor-acceptor system, composed of a zinc porphyrin (ZnP) and a fullerene (C₆₀), held together by an amidinium-carboxylate salt-bridge (ZnP‑H‧‧‧C₆₀). Two different...
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Confined nanopores and hydrogen bonds of polyoxometalates for continuous electricity generation from fluctuating humidity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D6SC00287K, Edge Article

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Tuo Ji, WeiLin Chen, Fan Liao, ZhenHui Kang
A continuous humidity power generation strategy based on polyoxometalates (POMs) with confined nanopores and hydrogen bonds for effectively collecting water molecules and maintaining water adsorption gradient in fluctuating environmental humidity.
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How Solvent Activity and Solute Solvation Control Electrode Potentials: Quantitative Insights from Li⁺ Insertion into TiO₂

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D6SC00393A, Edge Article

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Ludivine K/Bidi, Tom Rocca, Lucie Chen, Andrea Gutierrez Schindler, B. Limoges, Véronique Balland
Tuning electrolyte salt concentration has emerged as a powerful strategy to enhance the performance of rechargeable batteries by mitigating parasitic side reactions. Here, we introduce a unified and quantitative validation...
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Organic Supramolecular Assemblage Confined Photoluminescence

Chem. Sci., 2026, Accepted Manuscript
DOI: 10.1039/D5SC10066F, Review Article

Open Access

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Hengzhi Zhang, Yu Liu
Organic supramolecular hosts can selectively bond to small organic molecules with chromophores, inhibiting molecular motion and isolating quenching factors through spatial confinement, thereby enhancing fluorescence and phosphorescence emission and expanding...
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Large-scale protein conformational transitions revealed by weighted ensemble simulations and EPR

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC08971A, Edge Article

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Shramana Palit, Darian T. Yang, Xiaowei Bogetti, Anthony T. Bogetti, Olivia Wood, Sunil Saxena, Lillian T. Chong
Conformational exchange pathways of LAO binding protein revealed through an integrated EPR spectroscopy and weighted ensemble simulation approach.
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Resonator-based add-drop filters enabled by flexible polymorphic crystals with TADF-RTP motifs

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC08545D, Edge Article

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Pradip Pattanayak, Ankur Khapre, Shamim Ahmad, Avulu Vinod Kumar, Bishes Ray, Satendra Kumar, Chilla Malla Reddy, Rajadurai Chandrasekar, Pradipta Purkayastha
We demonstrate the use of yellow and green fluorescence (Y-FL and G-FL) obtained from polymorphic crystals as signals in an add-drop filter (P-ADF).
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Retraction: Supramolecular engineering cascade regulates NIR-II J-aggregates to improve photodynamic therapy

Chem. Sci., 2026, 17,6785-6785
DOI: 10.1039/D6SC90067D, Retraction

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Huizhe Wang, Huijia Liu, Wenqing Li, Shuai Li, Jiaqi Zhang, Jingzhe Zang, Li Liu, Peng Wang
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Symmetry-breaking charge separation in perylene diimide trimers: effects of aggregation and solvent polarity

Chem. Sci., 2026, Advance Article
DOI: 10.1039/D5SC09357K, Edge Article

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Lie Tian, Guangliu Ran, Shixuan Zheng, Wenkai Zhang
Symmetry-breaking charge separation (SB-CS) of a perylene diimide trimer occurs even in nonpolar solvent. In toluene, intermolecular aggregation enhances π–π interactions and promotes SB-CS, giving efficiency between that in chloroform and acetone.
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Correction: Suppressing nonradiative decay via molecular configuration control in Cu(I)–halide clusters enables the fabrication of highly efficient green and green-sensitized blue OLEDs

Chem. Sci., 2026, 17,6782-6782
DOI: 10.1039/D6SC90060G, Correction

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Xiao Li, Sai Guo, Xin Liu, Yu-Fu Sun, Dong-Hai Zhang, Hui Yang, Jia-Min Lu, Xu-Lin Chen
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Microenvironment regulation in nanomaterial synthesis

Chem. Sci., 2026, 17,6261-6282
DOI: 10.1039/D5SC08395H, Perspective

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Shuyi Pang, Yuanduo Li, Wenxia Xu, Hangkai Shi, Hongdong Li, Jingqi Chi, Jianping Lai, Lei Wang
This study shows that by precisely regulating local physicochemical conditions, spatial confinement, and external field assistance, the synthesis of nanomaterials is transformed from macroscopic mixing to microscopic precise control.
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Engineering manganese-based cathodes for low-cost and high-energy rechargeable batteries

Chem. Sci., 2026, 17,6345-6370
DOI: 10.1039/D5SC09895E, Review Article

Open Access

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Hongyu Zhang, Tingzhou Yang, Quan Zhou, Xiaoen Wang, Zhongwei Chen
Strategies and advanced characterization techniques to improve the commercial viability of manganese-based cathode materials in lithium/sodium-ion batteries.
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Peptide cages: bioinspired supramolecular architectures for next-generation applications

Chem. Sci., 2026, 17,6301-6323
DOI: 10.1039/D5SC08607H, Review Article

Open Access

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Simone Adorinni, Houyang Xu, Jonathan R. Nitschke, Silvia Marchesan
This review analyses peptide-based supramolecular cages, their design and applications.
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Architecting NIR-II metal supramolecular dyes—illuminating the path to precision medicine

Chem. Sci., 2026, 17,6283-6300
DOI: 10.1039/D6SC00523C, Perspective

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Fang Zhao, Qiao Song, Panxing Qiu, Xiaoxing Xiong, Youjia Tang, Yao Sun
This perspective outlines the design strategies of NIR-II metal supramolecular dyes. Applications in anticancer, antibacterial, and cardiovascular therapy, as well as bioimaging, are highlighted, along with challenges and future outlooks.
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Correction: Structural and spectroscopic basis of excitation energy transfer in microbial rhodopsins binding xanthophylls

Chem. Sci., 2026, 17,6783-6784
DOI: 10.1039/D6SC90054B, Correction

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Giacomo Salvadori, Piermarco Saraceno, Alisia Santomieri, Chris John, Laura Pedraza-González
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Microfluidic-mass spectrometry analysis of blood–brain barrier transport using engineered microparticle interfaces

Chem. Sci., 2026, 17,6371-6378
DOI: 10.1039/D5SC10112C, Edge Article

Open Access

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Shiyu Chen, Yingrui Zhang, Zengnan Wu, Tianze Xie, Tong Xu, Yi Zhang, Xianli Meng, Jin-Ming Lin
A barrier-mimetic analytical interface integrating multicellular blood–brain barrier particles with online metabolite detection enables dynamic interrogation of permeability-metabolism coupling for drug screening.
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Recent advances in small-molecule fluorescent probes for simultaneous dual detection of HClO/ClO− and analytes/microenvironment

Chem. Sci., 2026, 17,6324-6344
DOI: 10.1039/D5SC08843G, Review Article

Open Access

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Yongqing Zhou, Mei Yan, Hosoowi Lee, Juyoung Yoon
This review offers a comprehensive summary of dual-responsive small-molecule fluorescent probes for simultaneous monitoring of HClO/ClO⁻ and analytes/microenvironment in living systems.
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Vibrational snapshots of ultrafast C–H bond photoactivation inside a water-soluble nanocage

Chem. Sci., 2026, 17,6390-6401
DOI: 10.1039/D5SC05247E, Edge Article

Open Access

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Sunandita Paul, Shashi, Ankita Das, Dooshaye Moonshiram, Jyotishman Dasgupta
Photoactivation of C–H bonds inside enzyme-like nanocavities can enable organic transformations in water. Here we reveal structural dynamics of photoinduced PCET leading to C–H activation in a water-soluble nanocage.
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Active control of forward/backward charge transfer in Z-scheme water splitting: manipulating electrostatic affinity/repulsion between photocatalyst surface and electron mediator

Chem. Sci., 2026, 17,6379-6389
DOI: 10.1039/D5SC10049F, Edge Article

Open Access

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Ren Itagaki, Akinobu Nakada, Hajime Suzuki, Osamu Tomita, Ryu Abe
A designed cationic/neutral charge-switchable Co complex as an electron mediator enabled much improved Z-scheme overall water splitting via manipulation of electrostatic interaction.
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