RSC - Sens. Diagn. latest articles

A carbohydrate-based graphene field-effect transistor sensing system for rapid blood type detection

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00228A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yunqing Li, Pengyu Li, Yiping Yao, Weiwen Zhao
This study developed a novel dual-channel carbohydrate-based graphene field-effect transistor (C-GFET) sensing system to achieve rapid ABO blood typing.
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Structure-guided aggregation-regulated and coordination-assisted Zn–porphyrins for decoding aminoglycoside recognition in real-life samples

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00054A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nisha Chettri, Harshal V. Barkale, Satadru Jha, Nilanjan Dey
Aggregation-engineered Zn–porphyrins enable selective neomycin sensing via coordination-assisted supramolecular reorganization, producing a ratiometric fluorescence response with 0.75 μM detection limit and portable paper-strip applicability.
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A molecular switch framework for reagentless electrochemical detection of proteins

Sens. Diagn., 2026, 5,837-847
DOI: 10.1039/D6SD00048G, Paper

Open Access

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Erfan Shirzadi, Yue Xu, Mara Jenkins, Jianwen Wang, Sunandan Tandon, Gyorgy Jaics, Zoya Leonenko, Mahla Poudineh
This study presents the design and application of a molecular switch-based electrochemical biosensor to determine protein concentration in real-time.
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Establishment of a peptide-based electrochemical immunosensor for detecting antibodies against the GP5 protein from the porcine reproductive and respiratory syndrome virus

Sens. Diagn., 2026, 5,858-867
DOI: 10.1039/D6SD00034G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Luis Enrique Franco-Correa, Luis A. Ortiz-Frade, Alejandro Bravo Patiño, Francisco Perez-Duran, Fernando Calderón-Rico, Alicia Gabriela Zamora-Avilés, Martha Leticia Jiménez-González, Gabriel Espinosa, Daniel Durand-Herrera, Ricarda Cortés-Vieyra, Rosa Elvira Nuñez-Anita
A peptide-based electrochemical immunosensor detects anti-PRRSV in pig serum. EIS monitors electron transfer resistance changes on a gold electrode functionalized with a synthetic viral peptide after antigen–antibody binding.
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A multilayer fluorogenic material for the ultrasensitive detection of TATP in air, suitable for implementation on a mechanized semi-autonomous robotic platform

Sens. Diagn., 2026, 5,828-836
DOI: 10.1039/D5SD00218D, Paper

Open Access

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Irene Abajo-Cuadrado, Andrea Revilla-Cuesta, Ricardo Fernández-Ordóñez, J. Rafael Santana-Tejada, Yeray Moreno-Macías, Cristian Almeida-Estévez, Carla Hernando-Muñoz, José García-Calvo, Manuel Avella, Tomás Torroba
We describe a multilayer fluorogenic material, composed of a fluorescent probe supported on silica, PDMS and glass slides, implemented on a mechanized device for semi-autonomous measurements of airborne triacetone triperoxide in operational spaces.
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A novel label-free EC aptasensor for early detection of H9N2 influenza using FFT-square wave voltammetry and validated by molecular docking

Sens. Diagn., 2026, 5,868-883
DOI: 10.1039/D6SD00020G, Paper

Open Access

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Negar Heidari, Nogol D. Moghaddam, Sharmin Kharrazi, Jahan B. Ghasemi, Melika F. Aghdam, Mahdi Amrollahi Bioyki, Ebrahim Ghafar-Zadeh, Parviz Norouzi
H9N2 avian influenza threatens global poultry production and human health through cross-species transmission and its role as a genetic reservoir for emerging influenza strains, underscoring the need for rapid and reliable early detection.
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Fabrication methods and applications of printed wearable sensors for real-time sweat analysis: a comprehensive review

Sens. Diagn., 2026, 5,783-812
DOI: 10.1039/D5SD00221D, Critical Review

Open Access

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Pegah Bavafa, Yahya Sorkhe, Lia A. Stanciu, Aytekin Uzunoglu
Sweat analysis has emerged as a new approach for non-invasive and continuous health monitoring. Graphical abstract image modified using ChatGPT for visual refinement only.
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Contributors to the Sensors & Diagnostics Emerging Investigators Collection 2025

Sens. Diagn., 2026, 5,757-760
DOI: 10.1039/D6SD90006B, Profile

Open Access

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This article profiles the early career researchers whose work features in the Sensors & Diagnostics Emerging Investigators Collection 2025.
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Measurement-aligned finite element modeling for predictive design of dual-port SAW resonators

Sens. Diagn., 2026, 5,848-857
DOI: 10.1039/D6SD00016A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Hongyang Guo, Xiaojing Zhang, Xinxin Li, Ping Wang, Hao Jia, Liujing Zhuang
A measurement-aligned finite element method (MA-FEM) workflow that bridges standardized simulation and experimental SAW resonator performance, providing predictive high-Q maps as foundation for robust biomimetic arrays.
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Aptamer- and DNAzyme-based biosensors for pathogen detection: diagnostic strategies and clinical applications

Sens. Diagn., 2026, 5,761-782
DOI: 10.1039/D6SD00023A, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yunting Fan, Ruiqin Jiang, Hongyan Liu, Wei Tian, Meng Liu, Zijie Zhang
This review summarizes advances in aptamer- and DNAzyme-based biosensors for pathogen detection, provides guidance on selecting diagnostic approaches for diverse pathogens, and highlights progress toward clinical translation.
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Non-enzymatic sweat-based glucose sensors: progress, difficulties, and prospects

Sens. Diagn., 2026, 5,813-827
DOI: 10.1039/D6SD00042H, Tutorial Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

P. Kirubha, B. S. Sreeja, S. Fouziya Sulthana
Non-enzymatic sweat glucose sensors enable non-invasive, real-time monitoring using flexible wearables. Advances in nanomaterials and microfluidics improve performance, but challenges like interference, and calibration limit clinical translation.
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Cobalt molybdenum oxide nanorod decorated carbon yarn for non-enzymatic electrochemical detection of epinephrine

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00040A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Pranav Mecheri, Swathi Vaidyanatha Iyer, Lekshmi Bindu Raveendran, Mini Mol Menamparambath
Morphologically tuned cobalt molybdenum oxide nanorods as an efficient electrocatalyst for electrochemical detection of epinephrine.
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Bacteria-on-chip: a multiplexed point-of-care electrochemical platform for rapid detection of Escherichia coli and antimicrobial susceptibility testing

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00063K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sonal Fande, Areon Banerjee, Sanket Goel
A portable multiplexed electrochemical platform enables 30 min E. coli detection and simultaneous AST within 5 h, significantly reducing diagnostic time while providing selective, reproducible point-of-care antimicrobial resistance profiling.
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Development of colorimetric and fluorescent sensor based on a combination of ICT (intramolecular charge transfer) and FRET (Förster resonance energy transfer) for the detection of water

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00055J, Paper

Open Access

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Kosuke Okutani, Keiichi Imato, Yousuke Ooyama
An ICT (intramolecular charge transfer)/FRET (Förster resonance energy transfer)-type colorimetric and fluorescent sensor for the detection of water, pyridine-boron trifluoride complex KOY-1-BF₃, has been newly designed and developed.
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Single-nucleotide polymorphism detection based on an active-matrix digital microfluidics pyrosequencing lab-on-a-chip platform

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00032K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Huiting Hu, Tong Wang, Bingbing Zhang, Kai Jin, Zihan Wang, Qi Huang, Hanbin Ma, Jinhua Li, Zhiyao Chen, Siyi Hu
In this work, we developed an AM-DMF-based pyrosequencing platform for rapid and automated SNP detection, representing its first application in pharmacogenomic analysis. This approach simplifies the workflow, reduces costs, and enhances automation.
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Fluorescent Zn (II) Coordination Complexes as Advanced Bioimaging Probes for Sensitive Detection of Small Biomolecules

Sens. Diagn., 2026, Accepted Manuscript
DOI: 10.1039/D6SD00010J, Critical Review

Open Access

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Jamespandi Annaraj, Thavasilingam Nagendraraj, Suresh Sagadevan
Advancements in diagnostic imaging have significantly improved early disease detection. Techniques such as computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasound are widely used in...
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Development of a fluorescent lateral flow test for the detection of the metabolic biomarker leptin in human serum

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00062B, Paper

Open Access

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Margarita Ortiz-Martinez, Katerina Kourentzi, Richard C. Willson, Marco Rito-Palomares, Mirna González-González
A rapid fluorescence-based lateral flow immunoassay for sensitive leptin detection. The platform achieves a 0.25 ng mL⁻¹ LOD in 50% calf serum and was successfully validated using 30 human serum samples, showing high correlation with standard ELISA.
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Highly sensitive electrochemical sensor for uric acid using additively manufactured miniaturized microelectrodes for point-of-care applications

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00005C, Paper

Open Access

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Sanjeet Kumar, Satish Kumar Dubey, Sanket Goel
A miniaturized, 3D-printed electrochemical biosensor functionalized with MWCNTs and uricase enables rapid, ultrasensitive uric acid detection in serum, providing a scalable and low-cost platform for portable point-of-care diagnostics.
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