RSC - Sens. Diagn. latest articles

A non-invasive blister fluid-based rapid test for point-of-care detection of varicella and herpes zoster: preliminary validation in a clinical setting

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00231A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Fang-Ying Wang, Yi-You Huang, Chao-Min Cheng
A lateral flow assay for varicella-zoster virus enables rapid detection from blister fluid with visual, spectral, and smartphone-based analysis, providing a simple and accessible approach for point-of-care diagnosis.
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Engineering anthraimidazoledione charge-transfer fluorophores for phospholipid detection through self-assembly-induced emission

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00232J, Paper

Open Access

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Sourav Mondal, Nilanjan Dey
The anthraimidazoledione-based fluorescent probes for the selective detection of cardiolipin (CL) at pH 7.0 in PBS buffer (phosphate buffered saline).
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Recent advances in multiplexed electrochemiluminescence immunoassays

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00236B, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yu Liu, Chunyan Liu, Zhihui Dai, Weiliang Guo
Electrochemiluminescence (ECL) immunoassays enable powerful multiplex biomarker detection due to low background noise, high sensitivity, and ease of miniaturization, holding significant promise for precision medicine and in vitro diagnostics.
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Aptamer and DNAzyme for Pathogen Detection: Diagnostic Strategies and Clinical Applications

Sens. Diagn., 2025, Accepted Manuscript
DOI: 10.1039/D6SD00023A, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yunting Fan, Ruiqin Jiang, Hongyan Liu, Wei Tian, Meng Liu, Zijie Zhang
Pathogens that cause infectious diseases continue to pose threats to human health. The development of efficient and accurate diagnostic methods is essential for the prevention and control of pathogen infections....
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Non-Enzymatic Sweat-Based Glucose Sensors: Progress, Difficulties, and Prospects

Sens. Diagn., 2025, Accepted Manuscript
DOI: 10.1039/D6SD00042H, Tutorial Review

Open Access

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Kirubha Perumal, Sreeja B S, S Fouziya Sulthana
Effective diabetes therapy requires continuous glucose monitoring (CGM), yet existing blood-based measurement techniques are invasive and pose discomfort during prolonged use. Sweat's non-invasive collection, real-time secretion and compatibility with skin-conforming...
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Correction: Noninvasive and point-of-care screening of snoring by breath monitoring using ion-in-conjugation polymer-based humidity sensors

Sens. Diagn., 2026, 5,427-427
DOI: 10.1039/D5SD90050F, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ze-Kun Chen, Wei-Wei Bai, Ying-Qian Huo, Jing-Hui He
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Correction: Diffuse reflectance-based spectroscopic technique for real-time estimation of localized blood oxygenation parameters from human fingertips: a preliminary study

Sens. Diagn., 2026, 5,426-426
DOI: 10.1039/D5SD90049B, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ajay Kumar, Kalaivani Chellappan, Aulia Nasution, Dnyandeo Pawar, Manoj Kumar Patel, Rajesh Kanawade
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Correction: Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent vancomycin-based probe

Sens. Diagn., 2026, 5,425-425
DOI: 10.1039/D5SD90048D, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Richa Sharma, Harinee Rajagopalan, Maxime Klausen, Mani Vimalin Jeyalatha, Muhammed Üçüncü, Seshasailam Venkateswaran, Appakkudal R. Anand, Mark Bradley
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Development of an integrated label-free electrochemical sensor with sample collection for the detection of Acinetobacter baumannii

Sens. Diagn., 2026, 5,404-412
DOI: 10.1039/D5SD00130G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sallam Al-Madhagi, Souna Elwary, Luay Fawzi Abuqatouseh, Mohammed Zourob
Acinetobacter, a genus of bacteria capable of infecting humans, is found in the healthcare environment.
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Recent progress in current and emerging techniques for the detection of PFAS – the forever chemicals

Sens. Diagn., 2026, 5,305-325
DOI: 10.1039/D5SD00166H, Critical Review

Open Access

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Vibhas Chugh, Paul Gaskin, Waye Zhang
Per- and polyfluoroalkyl substances (PFAS) are now regulated at ultra-trace levels in drinking water, with guideline values in the low ng L⁻¹ (ppt) range in many jurisdictions, demanding highly sensitive, robust, and cost-effective monitoring tools.
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Acid-activation enhanced graphite additive manufactured polypropylene sensor for the detection of parathion in forensic and environmental samples

Sens. Diagn., 2026, 5,381-392
DOI: 10.1039/D5SD00125K, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Karen K. L. Augusto, Larissa M. A. Melo, Elena Bernalte, Robert D. Crapnell, Rodrigo A. A. Muñoz, Orlando Fatibello-Filho, Wallans T. P. dos Santos, Craig E. Banks
Through activation of graphite prior to filament production, sensors with greatly enhance performance can be produced.
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From laboratory to community: a perspective on colourimetric membrane sensor technologies for heavy metal monitoring in freshwater

Sens. Diagn., 2026, 5,326-336
DOI: 10.1039/D5SD00172B, Perspective

Open Access

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Alessio Polvani, Amedeo Boldrini, Riccardo Gaetano Cirrone, Xinyu Liu, Luisa Galgani, Fiona Regan, Abu Bakar Kamara, Mohamed Sahr E Juanah, Steven A. Loiselle
This perspective examines how colourimetric membrane sensors are moving from lab prototypes to community-based freshwater monitoring, highlighting advances, sustainability, and pathways to practical environmental use.
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ICT-driven Ag+ detection using xylene-spacer integrated naphthalene probes as fluorescent chemosensors: selectivity, practical monitoring, and anticounterfeiting

Sens. Diagn., 2026, 5,413-424
DOI: 10.1039/D5SD00202H, Paper

Open Access

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Narmatha Ganesan, Kavanya Srinivasan, Elizabeth Antony, Jan G. Malecki, Abisha Nancy Sukumar, Abiram Angamuthu, J. Prabhu, Raju Nandhakumar
Fluorescent probes ONA and MNA show strong, selective Ag⁺ emission via coordination modulation, with low detection limits and anti-interference. They enable Ag⁺ detection in soil, water, and anticounterfeiting for environmental and security sensing.
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MXene-supported Cu–Ag nanohybrids for electrochemical nitrate and nitrite detection in alkaline media

Sens. Diagn., 2026, 5,393-403
DOI: 10.1039/D5SD00187K, Paper

Open Access

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Vishwanath Ankalgi, Mohammed Arkham Belgami, Bhakti Kulkarni, Sang Mun Jeong, Chandra Sekhar Rout
Herein, we report the development of a Cu–Ag nanoparticle-decorated Ti₃C₂T_x MXene-based electrochemical sensor for the sensitive and selective detection of nitrate and nitrite.
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Electrochemical sensor for the detection of sunset yellow in food using a polyaniline/carbon nanopowder nanocomposite modified electrode

Sens. Diagn., 2026, 5,369-380
DOI: 10.1039/D5SD00134J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Judith Letsoalo, Gloria E. Uwaya, Omolola E. Fayemi
Food items frequently face the risk of adulteration, which can lead to serious health consequences.
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Quantitative single-particle profiling of extracellular vesicles via fluorescent nanoparticle tracking analysis

Sens. Diagn., 2026, 5,348-357
DOI: 10.1039/D5SD00119F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yiting Liu, Anthony James El-Helou, Bill Söderström, Juanfang Ruan, Ying Zhu
An optimised protocol for quantitative profiling of EVs at the single-particle level by fluorescent nanoparticle tracking analysis, which enables precise quantification of EV concentration, size distribution, and surface immunophenotype.
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π-Spacer modulation unlocking tunable photophysics and organelle-specificity in 2,6 disubstituted BODIPY-cyanostilbene fluorophores

Sens. Diagn., 2026, 5,337-347
DOI: 10.1039/D5SD00155B, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Charutha Kalarikkal, Sarbani Bhattacharjee, Koyeli Mapa, Chinna Ayya Swamy P
This work presents the rational design, synthesis, and comprehensive photophysical and biological evaluation of 2,6-π-extended BODIPY fluorophores featuring phenyl and thiophene linkers.
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Fluorogenic squaraine dimers for the flow cytometry detection of bacterial urinary tract infections

Sens. Diagn., 2026, 5,358-368
DOI: 10.1039/D5SD00160A, Paper

Open Access

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Lucille Weiss, Martijn Visser, Patrick Wagner, Anthony Augé, Océane Florès, Nicola Pordone, Martin Fayolle, Paul O. Verhoeven, Dmytro Dziuba, Dominique Bonnet, Julie Karpenko
A bacteria-specific fluorogenic probe integrating a squaraine dye dimer and an antimicrobial peptide enables fast and selective bacterial detection in patient urine by flow cytometry.
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Vibration technology-based droplet microfluidic devices for biomedical applications

Sens. Diagn., 2026, 5,270-304
DOI: 10.1039/D5SD00163C, Critical Review

Open Access

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Peng Yin, Yanna Lin, Maojie Jiang, Xiangyu Jiang, Xuan Fang, Mengjie Huang, Baihui Zhang, Fuqiang Ma
This review provides a concise summary of the fundamental principles, technological advancements, and representative biomedical applications of vibration-induced droplet manipulation.
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Biophysical characterization of spCas9 binding and cleavage using real-time electronic biosensors

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00227C, Paper

Open Access

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Deependra Kumar Ban, Kshama Parate, Deepta Bharadwaj, Austin Wong, Lorelai Schoch, Kenneth Visk, Kiana Aran
A label-free non-faradaic electrochemical impedance spectroscopy chip monitors spCas9-DNA binding in real time, detects mismatches, and reveals magnesium-dependent effects on specificity and residence time, enabling scalable gRNA prescreening.
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Transition metal dichalcogenides as platforms for biosensing, phototherapy, and drug delivery

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00238A, Critical Review

Open Access

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Yilin Tang, Ziheng Huang, Keyue Tian, Feng Luo
TMDCs can be prepared by mechanical exfoliation, CVD, or solution exfoliation, and can be functionalized with antibodies, peptides, or small molecules. Key barriers are biocompatibility, scalable production, and targeting.
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Correction: Rapid detection of Candida albicans in urine by an Electrochemical Impedance Spectroscopy (EIS)-based biosensor

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD90051D, Correction

Open Access

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Tina D'Aponte, Maria De Luca, Nikola Sakač, Martina Schibeci, Angela Arciello, Emanuela Roscetto, Maria Rosaria Catania, Vincenzo Iannotti, Raffaele Velotta, Bartolomeo Della Ventura
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