RSC - Sens. Diagn. latest articles

Development of colorimetric and fluorescent sensor based on a combination of ICT (intramolecular charge transfer) and FRET (Förster resonance energy transfer) for the detection of water

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00055J, Paper

Open Access

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Kosuke Okutani, Keiichi Imato, Yousuke Ooyama
An ICT (intramolecular charge transfer)/FRET (Förster resonance energy transfer)-type colorimetric and fluorescent sensor for the detection of water, pyridine-boron trifluoride complex KOY-1-BF₃, has been newly designed and developed.
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Single-nucleotide polymorphism detection based on an active-matrix digital microfluidics pyrosequencing lab-on-a-chip platform

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00032K, Paper

Open Access

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Huiting Hu, Tong Wang, Bingbing Zhang, Kai Jin, Zihan Wang, Qi Huang, Hanbin Ma, Jinhua Li, Zhiyao Chen, Siyi Hu
In this work, we developed an AM-DMF-based pyrosequencing platform for rapid and automated SNP detection, representing its first application in pharmacogenomic analysis. This approach simplifies the workflow, reduces costs, and enhances automation.
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Fluorescent Zn (II) Coordination Complexes as Advanced Bioimaging Probes for Sensitive Detection of Small Biomolecules

Sens. Diagn., 2026, Accepted Manuscript
DOI: 10.1039/D6SD00010J, Critical Review

Open Access

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Jamespandi Annaraj, Thavasilingam Nagendraraj, Suresh Sagadevan
Advancements in diagnostic imaging have significantly improved early disease detection. Techniques such as computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasound are widely used in...
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Development of a fluorescent lateral flow test for the detection of the metabolic biomarker leptin in human serum

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00062B, Paper

Open Access

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Margarita Ortiz-Martinez, Katerina Kourentzi, Richard C. Willson, Marco Rito-Palomares, Mirna González-González
A rapid fluorescence-based lateral flow immunoassay for sensitive leptin detection. The platform achieves a 0.25 ng mL⁻¹ LOD in 50% calf serum and was successfully validated using 30 human serum samples, showing high correlation with standard ELISA.
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Highly sensitive electrochemical sensor for uric acid using additively manufactured miniaturized microelectrodes for point-of-care applications

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00005C, Paper

Open Access

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Sanjeet Kumar, Satish Kumar Dubey, Sanket Goel
A miniaturized, 3D-printed electrochemical biosensor functionalized with MWCNTs and uricase enables rapid, ultrasensitive uric acid detection in serum, providing a scalable and low-cost platform for portable point-of-care diagnostics.
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Bacteria-on-Chip: A Multiplexed Point-of-Care Electrochemical Platform for Rapid Detection of Escherichia coli and Antimicrobial Susceptibility Testing

Sens. Diagn., 2026, Accepted Manuscript
DOI: 10.1039/D6SD00063K, Paper

Open Access

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Sonal Fande, Areon Banerjee, Sanket Goel
Urinary tract infections (UTIs), primarily caused by Escherichia coli (E. coli), are among the most prevalent bacterial infections, affecting millions of individuals each year. Along with this, the rising prevalence...
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Structure-Guided Aggregation-Regulated and Coordination-Assisted Zn–Porphyrins for Decoding Aminoglycoside Recognition in Real-Life Samples

Sens. Diagn., 2026, Accepted Manuscript
DOI: 10.1039/D6SD00054A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nisha Chettri, Harshal V Barkale, Satadru Jha, Nilanjan Dey
Herein, we report an aggregation-regulated Zn–porphyrin–based optical sensing platform for the selective detection of the aminoglycoside antibiotic neomycin in aqueous media and real-life samples. Three structurally related Zn–porphyrin derivatives with...
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Highly sensitive pH-modulated paper-based platform for point-of-care osteopontin quantification in osteoporosis screening

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00030D, Paper

Open Access

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Amandeep Kaur, Vikas, Sanjeev Soni, Suman Singh
Paper-based colorimetric biosensors detect osteoporosis biomarker osteopontin (OPN) using AuNP@Ab conjugates and phenol red. Immunocomplex formation induces a visible color change, quantified with ImageJ.
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Design and mechanistic study of a high-sensitivity small-molecule fluorescent probe for the detection of microcystin-LR

Sens. Diagn., 2026, 5,687-696
DOI: 10.1039/D6SD00036C, Paper

Open Access

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Jinfeng Chen, Zhicen Qiu, Linyu Fan, Yisang Lu, Silong Li, Yuxin Yang, Wanhe Wang, Cheuk-Lam Ho, Xiao Yao, Zhuwu Jiang
Cyanobacterial bloom-derived microcystin-LR (MC-LR) poses serious threats to aquatic ecosystems and human health, while conventional analytical methods often require expensive instrumentation and labor-intensive procedures.
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Discussion of study limitations strengthens research through transparency

Sens. Diagn., 2026, 5,622-623
DOI: 10.1039/D6SD90010K, Editorial

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xueji Zhang, Anna Rulka
Sensors & Diagnostics is committed to publishing rigorous research. We therefore require authors of all research articles to describe the study limitations in the Discussion section, supporting responsible interpretation and greater research impact.
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First annual Sensors & Diagnostics Emerging Investigators collection

Sens. Diagn., 2026, 5,624-624
DOI: 10.1039/D6SD90005D, Editorial

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

This collection showcases research carried out by internationally recognised, up-and-coming scientists in the early stage of their independent careers who are making outstanding contributions to their respective fields.
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Quantification of avian influenza A virus (H5N1) via enzymatic reactions and glucometer test strips

Sens. Diagn., 2026, 5,739-748
DOI: 10.1039/D6SD00003G, Paper

Open Access

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Md Reazul Islam, Faisal Hossain, Michael A. Joyce, Mohamed Elaish, D. Lorne Tyrrell, Tom C. Hobman, Michael J. Serpe
Enzymatic detection of H5N1 using glucose test strips.
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A non-invasive blister fluid-based rapid test for point-of-care detection of varicella and herpes zoster: preliminary validation in a clinical setting

Sens. Diagn., 2026, 5,730-738
DOI: 10.1039/D5SD00231A, Paper

Open Access

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Fang-Ying Wang, Yi-You Huang, Chao-Min Cheng
A lateral flow assay for varicella-zoster virus enables rapid detection from blister fluid with visual, spectral, and smartphone-based analysis, providing a simple and accessible approach for point-of-care diagnosis.
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Engineering anthraimidazoledione charge-transfer fluorophores for phospholipid detection through self-assembly-induced emission

Sens. Diagn., 2026, 5,697-704
DOI: 10.1039/D5SD00232J, Paper

Open Access

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Sourav Mondal, Nilanjan Dey
The anthraimidazoledione-based fluorescent probes for the selective detection of cardiolipin (CL) at pH 7.0 in PBS buffer (phosphate buffered saline).
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Transition metal dichalcogenides as platforms for biosensing, phototherapy, and drug delivery

Sens. Diagn., 2026, 5,649-673
DOI: 10.1039/D5SD00238A, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yilin Tang, Ziheng Huang, Keyue Tian, Feng Luo
TMDCs can be prepared by mechanical exfoliation, CVD, or solution exfoliation, and can be functionalized with antibodies, peptides, or small molecules. Key barriers are biocompatibility, scalable production, and targeting.
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Recent advances in multiplexed electrochemiluminescence immunoassays

Sens. Diagn., 2026, 5,674-686
DOI: 10.1039/D5SD00236B, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yu Liu, Chunyan Liu, Zhihui Dai, Weiliang Guo
Electrochemiluminescence (ECL) immunoassays enable powerful multiplex biomarker detection due to low background noise, high sensitivity, and ease of miniaturization, holding significant promise for precision medicine and in vitro diagnostics.
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Biophysical characterization of spCas9 binding and cleavage using real-time electronic biosensors

Sens. Diagn., 2026, 5,718-729
DOI: 10.1039/D5SD00227C, Paper

Open Access

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Deependra Kumar Ban, Kshama Parate, Deepta Bharadwaj, Austin Wong, Lorelai Schoch, Kenneth Visk, Kiana Aran
A label-free non-faradaic electrochemical impedance spectroscopy chip monitors spCas9-DNA binding in real time, detects mismatches, and reveals magnesium-dependent effects on specificity and residence time, enabling scalable gRNA prescreening.
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Engineered bacteria-enabled biosensing: integration with artificial intelligence for enhanced diagnostic precision

Sens. Diagn., 2026, 5,625-648
DOI: 10.1039/D5SD00200A, Critical Review

Open Access

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Qiuke Jing, Hongmei Liu, Decheng Wu
This review explores the synergy of synthetic biology and AI in developing intelligent bacterial biosensors. It covers core design principles, AI-driven optimization, and diverse detection applications across various fields.
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Unlocking the potential of proton-mediated detection of ascorbic acid with a Ni–Co bimetallic MOF based extended gate FET

Sens. Diagn., 2026, 5,705-717
DOI: 10.1039/D5SD00217F, Paper

Open Access

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Guru Prasad Kuppuswamy, Akshaya Vinukumar, Kishore Pushparaj, Sujitha Murugaiyan, Larisa Lvova, Surya Velappa Jayaraman, Corrado Di Natale, Yuvaraj Sivalingam
The possibility to quantify ascorbic acid (AA) using a Ni–Co MOF-coated carbon paper electrode within an extended gate FET setup (EGFET), operated at zero gate potential (open-circuit potential, OCP), has been investigated.
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Translational opportunities in aptamer and nanobody lateral flow assays within the WHO REASSURED framework

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00028B, Critical Review

Open Access

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Evan T. Monk, Erin M. McConnell, David R. McMullin, Maria C. DeRosa
Aptamer- and nanobody-based lateral flow assays achieve analytical performance comparable to antibodies, yet remain unapproved as IVDs. Translational progress is constrained by antibody-centric regulatory frameworks rather than assay performance.
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Rapid and portable molecular test for Mycobacterium sp. based on double-tagging amplification and electrochemical readout

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00037A, Paper

Open Access

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Melania Mesas Gómez, Daniel Ropero Gil, Bárbara Molina-Moya, Arnau Pallarès-Rusiñol, Jofre Ferrer-Dalmau, Esther Julián, José Domínguez, María Isabel Pividori
A portable TB molecular workflow couples double-tagging PCR with magnetic electrochemical genosensing in a disposable cartridge, enabling sensitive detection with battery-operated instrumentation.
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