RSC - Sens. Diagn. latest articles

Engineered bacteria-enabled biosensing: integration with artificial intelligence for enhanced diagnostic precision

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00200A, Critical Review

Open Access

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Qiuke Jing, Hongmei Liu, Decheng Wu
This review explores the synergy of synthetic biology and AI in developing intelligent bacterial biosensors. It covers core design principles, AI-driven optimization, and diverse detection applications across various fields.
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Low-cost printed circuit board (PCB) electrochemical biosensors for rapid and label-free detection of Streptococcus pneumoniae

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00210A, Paper

Open Access

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Vincent Vezza, Veerappan Mani, Niamh Docherty, Adrian Butterworth, David Alcorn, Paul A. Hoskisson, Damion Corrigan
Severe sepsis presents a critical healthcare challenge where rapid pathogen identification is vital for timely intervention.
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A DSE–ESIPT-active organic luminogen for “turn-on” enantioselective recognition of chiral amino alcohols and selective hydrazine sensing

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00214A, Paper

Open Access

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Aakash Venkatesan, Baru Venkata Naga Sahithi, Francis Joy, Rupali Patel, Aatika Nizam, Vasantha Veerappa Lakshmaiah
The development of DSE organic luminogens has increased the ease of enantioselective recognition of biological analytes, demonstrating the multifaceted potential of dual-state emitters.
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Unlocking the potential of proton-mediated detection of Ascorbic acid with Ni-Co Bimetallic MOF based Extended Gate FET

Sens. Diagn., 2025, Accepted Manuscript
DOI: 10.1039/D5SD00217F, Paper

Open Access

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GURU PRASAD KUPPUSWAMY, Akshaya Vinukumar, Kishore Pushparaj, Sujitha Murugaiyan, Larisa Lvova, Surya Velappa Jayaraman, Corrado Di Natale, Yuvaraj Sivalingam
The possibility to quantify ascorbic acid (AA) using a Ni-Co MOF-coated carbon paper electrode within an extended gate FET setup (EGFET), operated at zero gate potential (open-circuit potential, OCP) has...
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1,8-Naphthalimide-derived reactivity-based fluorescent probes for detection and imaging of H2S

Sens. Diagn., 2026, 5,184-207
DOI: 10.1039/D5SD00201J, Tutorial Review

Open Access

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Mannanthara Kunhumon Noushija, Alenthwar Vamshi Krishna, Sankarasekaran Shanmugaraju
This review summarizes recent advances in 1,8-naphthalimide-based reactivity probes for H₂S detection and imaging.
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Reproducible single-molecule optofluidic-SERS analysis on nanostar-activated diatom biosilica capsules

Sens. Diagn., 2026, 5,248-259
DOI: 10.1039/D5SD00161G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Subhavna Juneja, Sudipta Biswas, Kang Rong, Alan X. Wang
Single-molecule (SM) analysis with surface-enhanced Raman scattering (SERS) based on plasmonic nanostars on diatom photonic crystal biosilica.
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Adenosine detection technologies: recent advances and applications in the central nervous system

Sens. Diagn., 2026, 5,165-183
DOI: 10.1039/D5SD00170F, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yuqin Liao, Jiayuan Jing, Wenkai Jin, Xiangdong Tian, Tianhuan Peng, Lei Zhang, Quan Yuan
Overview of adenosine detection techniques and their applications in the central nervous system.
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A nucleic acid-based electrochemical detection method for post hoc sample analysis

Sens. Diagn., 2026, 5,208-212
DOI: 10.1039/D5SD00164A, Communication

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Logan T. Echeveria, Sadi Shahriar, Allison M. Yorita, Erkin Seker
This work introduces a new electrochemical sensing approach, where the liquid sample containing nucleic acid targets can be blotted onto an electrode that is pre-functionalized with probe DNA for offline analysis.
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Artificial intelligence-powered signal analysis of loop-mediated isothermal amplification (LAMP) for the screening of Kaposi sarcoma at the point of care

Sens. Diagn., 2026, 5,242-247
DOI: 10.1039/D5SD00068H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Darke Hull, Juan Boza, Jason Manning, Xinying Chu, Ethel Cesarman, Aggrey Semeere, Jeffrey Martin, David Erickson
Loop-mediated isothermal amplification (LAMP) based diagnostics lack a consistent thermal cycle, making quantification challenging. Artificial Intelligence can enhance Kaposi Sarcoma screening based on fitting parameters of LAMP signals.
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Enhancing wearable piezoelectric sensors via micro-textured P(VDF–TrFE)/BaTiO3 nanofiber mats for physiological monitoring

Sens. Diagn., 2026, 5,223-231
DOI: 10.1039/D5SD00175G, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yan Xu, Shiman Yang, Cheng Liu, Haoyu Wu, Kaiping Huang, Wenhui Xu, Jiahe Wang, Yichun Ding
Our work presents a micro-textured piezoelectric nanofiber mat, fabricated using a simple paper-templated process, which achieves high sensitivity (∼197 mV kPa⁻¹) and durability for monitoring a wide range of human physiological signals and motions.
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Species-specific discrimination of bacterial biofilms using a ratiometric fluorescence sensor array and machine learning

Sens. Diagn., 2026, 5,232-241
DOI: 10.1039/D5SD00152H, Paper

Open Access

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Ritika Gupta, Aayushi Laliwala, Elena Muldiiarova, Kenneth W. Bayles, Denis Svechkarev, Marat R. Sadykov, Aaron M. Mohs
A paper-based sensor array comprised of four ratiometric fluorescent dyes to analyze bacterial biofilms. Using pattern recognition, it can identify biofilm-forming species and distinguish between planktonic cultures and biofilms with high accuracy.
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Emerging trends in aerogel technology for sensing and biosensing applications

Sens. Diagn., 2026, 5,136-164
DOI: 10.1039/D5SD00100E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Aneesh Koyappayil, Gopi Karuppaiah, Sachin Ganpat Chavan, Anna Go, Hyung Chul Kim, Min-Ho Lee
Aerogels for sensing and biosensing applications.
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Nanomaterial-enhanced electrochemical biosensors for rifampicin monitoring in serum: towards precision tuberculosis therapy

Sens. Diagn., 2026, 5,213-222
DOI: 10.1039/D5SD00165J, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Rohith Shetty, Sudhaunsh Deshpande, Anu Mary Joy, Ajith Mohan Arjun, Qianming Xu, Alison Holmes, Sanjiv Sharma
A HPG electrode with a rifampicin-imprinted polymer selectively binds rifampicin from serum, producing a characteristic decrease in electrochemical signal compared with the baseline.
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Microfluidic platforms for CRISPR-based biosensing advancing molecular diagnostics from benchtop to point-of-care

Sens. Diagn., 2026, 5,116-135
DOI: 10.1039/D5SD00176E, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Yanping Wang, Huimin Jiang, Yanyin Zhang, Qingran Yang, Yujun Song, Yanfeng Gao
This review highlights recent advances in microfluidics-integrated CRISPR–Cas systems for rapid, sensitive, and portable detection of diverse biomarkers, emphasizing their potential to enable sample-to-answer point-of-care diagnostics.
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Nanoplasmonic core–shell nanoraspberry chip for ultrasensitive surface-enhanced Raman scattering detection of SARS-CoV-2: a modular nanobiosensor for respiratory virus diagnostics

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00185D, Paper

Open Access

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Nnamdi Nwahara, Saba Niaz, Muthumuni Managa, Christian I. Nkanga, Oluwasesan Adegoke, Ojodomo J. Achadu
The development of robust and ultrasensitive point-of-care diagnostics for viral pathogens, remains a critical challenge, as traditional biosensing platforms often suffer from signal instability and poor performance in complex biological matrices.
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Correction: Noninvasive and point-of-care screening of snoring by breath monitoring using ion-in-conjugation polymer-based humidity sensors

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD90050F, Correction

Open Access

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Ze-Kun Chen, Wei-Wei Bai, Ying-Qian Huo, Jing-Hui He
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Correction: Diffuse reflectance-based spectroscopic technique for real-time estimation of localized blood oxygenation parameters from human fingertips: a preliminary study

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD90049B, Correction

Open Access

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Ajay Kumar, Kalaivani Chellappan, Aulia Nasution, Dnyandeo Pawar, Manoj Kumar Patel, Rajesh Kanawade
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Correction: Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent vancomycin-based probe

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD90048D, Correction

Open Access

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Richa Sharma, Harinee Rajagopalan, Maxime Klausen, Mani Vimalin Jeyalatha, Muhammed Üçüncü, Seshasailam Venkateswaran, Appakkudal R. Anand, Mark Bradley
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Recognition of illicit date rape drugs: a luminescence sensing perspective

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00186B, Tutorial Review

Open Access

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Sunita Kyndait, Trisha Das, Dikshit Bokotial, Aniket Chowdhury
The consumption of recreational and addictive substances has rapidly increased owing to the legalisation of cannabinoids and the emergence of new potent synthetic psychoactive substances such as stimulants, depressants, and opioids.
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