RSC - Sens. Diagn. latest articles

Design and mechanistic study of a high-sensitivity small-molecule fluorescent probe for the detection of microcystin-LR

Sens. Diagn., 2026, 5,687-696
DOI: 10.1039/D6SD00036C, Paper

Open Access

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Jinfeng Chen, Zhicen Qiu, Linyu Fan, Yisang Lu, Silong Li, Yuxin Yang, Wanhe Wang, Cheuk-Lam Ho, Xiao Yao, Zhuwu Jiang
Cyanobacterial bloom-derived microcystin-LR (MC-LR) poses serious threats to aquatic ecosystems and human health, while conventional analytical methods often require expensive instrumentation and labor-intensive procedures.
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Discussion of study limitations strengthens research through transparency

Sens. Diagn., 2026, 5,622-623
DOI: 10.1039/D6SD90010K, Editorial

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Xueji Zhang, Anna Rulka
Sensors & Diagnostics is committed to publishing rigorous research. We therefore require authors of all research articles to describe the study limitations in the Discussion section, supporting responsible interpretation and greater research impact.
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First annual Sensors & Diagnostics Emerging Investigators collection

Sens. Diagn., 2026, 5,624-624
DOI: 10.1039/D6SD90005D, Editorial

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

This collection showcases research carried out by internationally recognised, up-and-coming scientists in the early stage of their independent careers who are making outstanding contributions to their respective fields.
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Quantification of avian influenza A virus (H5N1) via enzymatic reactions and glucometer test strips

Sens. Diagn., 2026, 5,739-748
DOI: 10.1039/D6SD00003G, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Md Reazul Islam, Faisal Hossain, Michael A. Joyce, Mohamed Elaish, D. Lorne Tyrrell, Tom C. Hobman, Michael J. Serpe
Enzymatic detection of H5N1 using glucose test strips.
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A non-invasive blister fluid-based rapid test for point-of-care detection of varicella and herpes zoster: preliminary validation in a clinical setting

Sens. Diagn., 2026, 5,730-738
DOI: 10.1039/D5SD00231A, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Fang-Ying Wang, Yi-You Huang, Chao-Min Cheng
A lateral flow assay for varicella-zoster virus enables rapid detection from blister fluid with visual, spectral, and smartphone-based analysis, providing a simple and accessible approach for point-of-care diagnosis.
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Engineering anthraimidazoledione charge-transfer fluorophores for phospholipid detection through self-assembly-induced emission

Sens. Diagn., 2026, 5,697-704
DOI: 10.1039/D5SD00232J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sourav Mondal, Nilanjan Dey
The anthraimidazoledione-based fluorescent probes for the selective detection of cardiolipin (CL) at pH 7.0 in PBS buffer (phosphate buffered saline).
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Transition metal dichalcogenides as platforms for biosensing, phototherapy, and drug delivery

Sens. Diagn., 2026, 5,649-673
DOI: 10.1039/D5SD00238A, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yilin Tang, Ziheng Huang, Keyue Tian, Feng Luo
TMDCs can be prepared by mechanical exfoliation, CVD, or solution exfoliation, and can be functionalized with antibodies, peptides, or small molecules. Key barriers are biocompatibility, scalable production, and targeting.
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Recent advances in multiplexed electrochemiluminescence immunoassays

Sens. Diagn., 2026, 5,674-686
DOI: 10.1039/D5SD00236B, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yu Liu, Chunyan Liu, Zhihui Dai, Weiliang Guo
Electrochemiluminescence (ECL) immunoassays enable powerful multiplex biomarker detection due to low background noise, high sensitivity, and ease of miniaturization, holding significant promise for precision medicine and in vitro diagnostics.
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Biophysical characterization of spCas9 binding and cleavage using real-time electronic biosensors

Sens. Diagn., 2026, 5,718-729
DOI: 10.1039/D5SD00227C, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Deependra Kumar Ban, Kshama Parate, Deepta Bharadwaj, Austin Wong, Lorelai Schoch, Kenneth Visk, Kiana Aran
A label-free non-faradaic electrochemical impedance spectroscopy chip monitors spCas9-DNA binding in real time, detects mismatches, and reveals magnesium-dependent effects on specificity and residence time, enabling scalable gRNA prescreening.
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Engineered bacteria-enabled biosensing: integration with artificial intelligence for enhanced diagnostic precision

Sens. Diagn., 2026, 5,625-648
DOI: 10.1039/D5SD00200A, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Qiuke Jing, Hongmei Liu, Decheng Wu
This review explores the synergy of synthetic biology and AI in developing intelligent bacterial biosensors. It covers core design principles, AI-driven optimization, and diverse detection applications across various fields.
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Unlocking the potential of proton-mediated detection of ascorbic acid with a Ni–Co bimetallic MOF based extended gate FET

Sens. Diagn., 2026, 5,705-717
DOI: 10.1039/D5SD00217F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Guru Prasad Kuppuswamy, Akshaya Vinukumar, Kishore Pushparaj, Sujitha Murugaiyan, Larisa Lvova, Surya Velappa Jayaraman, Corrado Di Natale, Yuvaraj Sivalingam
The possibility to quantify ascorbic acid (AA) using a Ni–Co MOF-coated carbon paper electrode within an extended gate FET setup (EGFET), operated at zero gate potential (open-circuit potential, OCP), has been investigated.
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Highly Sensitive Electrochemical Sensor for Uric Acid Using Additively Manufactured Miniaturized Microelectrodes for Point of Care Application

Sens. Diagn., 2026, Accepted Manuscript
DOI: 10.1039/D6SD00005C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sanjeet Singh, Satish Kumar Dubey, Sanket Goel
Point of care (PoC) biofluid diagnostics is hindered by the fundamental limitations of traditional electrochemical platforms, namely their complex fabrication, prohibitive cost, and reliance on benchtop instruments. To address these...
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Translational opportunities in aptamer and nanobody lateral flow assays within the WHO REASSURED framework

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00028B, Critical Review

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Evan T. Monk, Erin M. McConnell, David R. McMullin, Maria C. DeRosa
Aptamer- and nanobody-based lateral flow assays achieve analytical performance comparable to antibodies, yet remain unapproved as IVDs. Translational progress is constrained by antibody-centric regulatory frameworks rather than assay performance.
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Rapid and portable molecular test for Mycobacterium sp. based on double-tagging amplification and electrochemical readout

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00037A, Paper

Open Access

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Melania Mesas Gómez, Daniel Ropero Gil, Bárbara Molina-Moya, Arnau Pallarès-Rusiñol, Jofre Ferrer-Dalmau, Esther Julián, José Domínguez, María Isabel Pividori
A portable TB molecular workflow couples double-tagging PCR with magnetic electrochemical genosensing in a disposable cartridge, enabling sensitive detection with battery-operated instrumentation.
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A molecular switch framework for reagentless electrochemical detection of proteins

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00048G, Paper

Open Access

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Erfan Shirzadi, Yue Xu, Mara Jenkins, Jianwen Wang, Sunandan Tandon, Gyorgy Jaics, Zoya Leonenko, Mahla Poudineh
This study presents the design and application of a molecular switch-based electrochemical biosensor to determine protein concentration in real-time.
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A novel label-free EC aptasensor for early detection of H9N2 influenza using FFT-square wave voltammetry and validated by molecular docking

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00020G, Paper

Open Access

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Negar Heidari, Nogol D. Moghaddam, Sharmin Kharrazi, Jahan B. Ghasemi, Melika F. Aghdam, Mahdi Amrollahi Bioyki, Ebrahim Ghafar-Zadeh, Parviz Norouzi
H9N2 avian influenza threatens global poultry production and human health through cross-species transmission and its role as a genetic reservoir for emerging influenza strains, underscoring the need for rapid and reliable early detection.
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Establishment of a peptide-based electrochemical immunosensor for detecting antibodies against the GP5 protein from the porcine reproductive and respiratory syndrome virus

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D6SD00034G, Paper

Open Access

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Luis Enrique Franco-Correa, Luis A. Ortiz-Frade, Alejandro Bravo Patiño, Francisco Perez-Duran, Fernando Calderón-Rico, Alicia Gabriela Zamora-Avilés, Martha Leticia Jiménez-González, Gabriel Espinosa, Daniel Durand-Herrera, Ricarda Cortés-Vieyra, Rosa Elvira Nuñez-Anita
A peptide-based electrochemical immunosensor detects anti-PRRSV in pig serum. EIS monitors electron transfer resistance changes on a gold electrode functionalized with a synthetic viral peptide after antigen–antibody binding.
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A multilayer fluorogenic material for the ultrasensitive detection of TATP in air, suitable for implementation on a mechanized semi-autonomous robotic platform

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00218D, Paper

Open Access

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Irene Abajo-Cuadrado, Andrea Revilla-Cuesta, Ricardo Fernández-Ordóñez, J. Rafael Santana-Tejada, Yeray Moreno-Macías, Cristian Almeida-Estévez, Carla Hernando-Muñoz, José García-Calvo, Manuel Avella, Tomás Torroba
We describe a multilayer fluorogenic material, composed of a fluorescent probe supported on silica, PDMS and glass slides, implemented on a mechanized device for semi-autonomous measurements of airborne triacetone triperoxide in operational spaces.
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Single-Nucleotide Polymorphisms Detection Base on Active-Matrix Digital Microfluidics Pyrosequencing Lab-on-a-chip Platform

Sens. Diagn., 2025, Accepted Manuscript
DOI: 10.1039/D6SD00032K, Paper

Open Access

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Huiting Hu, Tong Wang, Bingbing Zhang, Kai Jin, Zihan Wang, Qi Huang, Hanbin Ma, Jinhua Li, Zhiyao Chen, Siyi Hu
Single-nucleotide polymorphisms (SNPs), as the most prevalent form of single-base variations within the genome, play a critical role in modulating protein function, regulating gene expression, and determing individual disease susceptibility,...
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Fabrication methods and applications of printed wearable sensors for real-time sweat analysis: a comprehensive review

Sens. Diagn., 2026, Advance Article
DOI: 10.1039/D5SD00221D, Critical Review

Open Access

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Pegah Bavafa, Yahya Sorkhe, Lia A. Stanciu, Aytekin Uzunoglu
Sweat analysis has emerged as a new approach for non-invasive and continuous health monitoring.
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