RSC - J. Mater. Chem. B latest articles

Rational design of structurally rich DNA aptamer screening libraries guided by empirical sequence trends and stable loop motifs

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02085A, Paper

Steven Ochoa, Valeria Tohver Milam
Graphical depiction of sequence parameters such as nucleotide content bias or self-folded structural motifs that enhance aptamer performance measured as “aptamer fitness”.
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Synthesis of β-aminoacrylated betulin derivatives by a spontaneous amino–yne reaction for antifungal applications

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02414E, Paper

Jiahui Lin, Jing Xiang, Kaojin Wang, Zhiyuan Ma, Weiwei Zuo
Betulin, a lupane-based pentacyclic triterpenoid, is renowned for its sustainability and potent antifungal properties.
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A pH-responsive multifunctional sericin–pyrrole hydrogel with inherent antibacterial and antioxidant activities

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02564H, Paper

Weiyang Wang, Akou May Tehoungue, Zilong Gao, Yi Wang, Manyi Sun, Yixue Lu, Guozheng Zhang, Yeshun Zhang
Hydrogels derived from natural materials with intrinsic bioactivities and pH responsiveness have attracted considerable interest in biomedical applications due to their versatile functionality.
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Collagen-based hydrogel patch promotes renal wound repair

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02370J, Communication

Chen Cheng, Zihao Fu, Chi Zhang, Fangfang Wang, Zonghuan Wang, Ying Chen, Yingjie Zhou, Jin Mei
A pre-formed hydrogel patch, integrating collagen as a multifunctional cross-linker, uniquely combines robust wet tissue adhesion with low swelling to achieve rapid hemostasis and promote orderly regeneration in partial nephrectomy.
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Injectable hydrogel-based localized delivery of IDO-galectin-3 mitigates neuroinflammation and promotes neuronal sparing after spinal cord contusion in rats

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02228B, Paper

Gopal Agarwal, Allison Campbell, Arun Wanchoo, Daniel Plant, Izabela Zmirska, Jacob Fuhr, Prodip Bose, Gregory A. Hudalla, Benjamin G. Keselowsky, Christine E. Schmidt
An immunomodulatory hydrogel, IDO-Gal3 incorporated into decellularized rat peripheral nerve (iPN), was injected into the thoracic contused rat spinal cord to evaluate its effects on astrocyte and microglial reactivity, as well as neuronal sparing.
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Ionizable mesoporous silica nanoparticle-mediated siAURKB delivery for colorectal cancer therapy

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02754C, Paper

Yuhao Yao, Yuheng Leng, Xilong Li, Pengcheng Chen, Jinglin Zou, Lei Shi, Dapeng Zhang, Yongsheng Li
An ionizable mesoporous silica nanoparticle (MSN) for siRNA delivery was developed by modifying diethylamino groups onto the surface. After loading with Aurora-B siRNA, the formulated nanomedicine realized effective colorectal cancer therapy.
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Live bacteria microneedles for biomedical applications

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D6TB00056H, Review Article

Junfeng Feng, Yu Wang, Letong Huang, Kun Guo, Guangyan Du
This review summarizes recent advances in MN-mediated live bacterial delivery systems, focusing on their applications in biomedical field, representative bacteria, key challenges and future development prospects.
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Effective inhibition of lung metastatic melanoma by pH-responsive lipopeptide/PLGA hybrid nanoparticles silencing PD-L1 with augmented suppression of the AKT/β-catenin pathway

J. Mater. Chem. B, 2026, 14,2963-2976
DOI: 10.1039/D5TB02487K, Paper

Ziyu Yang, Siqi Wang, Zilin Song, Rong Guo, Dawei Ding, Yan Gao, Mingxi Qiao
This study proposed a novel strategy to effectively inhibit lung metastatic melanoma by suppressing the AKT/β-catenin pathway by virtue of pH-responsive C₁₈-pArg₈-pHis₁₀-based lipopeptide hybrid nanoparticles.
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An AI-assisted hyperbranched RCA-based colorimetric biosensing platform for ultrasensitive detection of BPA

J. Mater. Chem. B, 2026, 14,2951-2962
DOI: 10.1039/D5TB02437D, Paper

Ningning Yuan, Muqaddas Raza, Yuanjun Gao, Ruyi Zhang, Zhenglan Huang, Guowei Zuo
Schematic illustration of the aptamer recognition–triggered HRCA strategy for ultrasensitive colorimetric detection of BPA (A), coupled with AI‑assisted quantification (B).
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Carbon dot nanoparticles as multifunctional fluorescent probes: from tunable synthesis to biomedical applications

J. Mater. Chem. B, 2026, 14,2795-2814
DOI: 10.1039/D5TB02569A, Review Article

Ahmed Mohammed Ali Abdulkhaleq, Zhonghua Jiang, Hai Chen, Ridong Huang, LingLing Ma, He Yang, Wuyu Mao
Carbon dots are fluorescence nanoparticles used in bioimaging of various biological molecules in diverse key disease areas.
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Pickering high internal phase emulsion templated poly(ε-caprolactone) scaffolds functionalized using type 1 collagen for enhanced bioactivity

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02727F, Paper

Meenal Agrawal, Doyel Ghosal, Bhanu Nandan, Sachin Kumar, Rajiv K. Srivastava
The inertness of poly(ɛ-caprolactone) scaffolds was overcome using hydroxyethyl cellulose as a macroinitiator to introduce functional sites for type I collagen immobilization, enhancing their bioactivity and suitability for biomedical applications.
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Co-delivery of loaded 4-butylresorcinol and licochalcone A in a supramolecular system for synergistic permeation and whitening effects

J. Mater. Chem. B, 2026, 14,2940-2950
DOI: 10.1039/D5TB01755F, Paper

Beibei Lu, Tao Zhang, Yue Liu, Xuefang Shi, Yimeng Wang, Bo Ruan, Jiaheng Zhang
Supramolecular BR-LicoA-VE has good skin permeability and stability, which can significantly reduce the melanin content in the skin. It has potential application value in whitening and skincare.
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Electrospun polymeric scaffolds enable 3D tissue-like functionality and efficient photoinduced contraction

J. Mater. Chem. B, 2026, 14,2832-2842
DOI: 10.1039/D5TB02640G, Communication

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Giulia Simoncini, Fabio Marangi, Ilaria Venturino, Vito Vurro, Andrea Bartolucci, Lorenzo Vannozzi, Ludovico Aloisio, Martina Rossi, Paola Moretti, Chiara Bertarelli, Giuseppe Maria Paternò, Guglielmo Lanzani
Free-standing, aligned electrospun PVA nanofiber membranes create a quasi-3D scaffold for C2C12 alignment. With Ziapin2 infiltration, visible light paces macroscopic contractions up to ∼460 µN (∼3.3 kPa) without genetics in vitro.
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Celebrating 25 years of the Sakiyama-Elbert lab: a look back on the evolution of neural biomaterials and future directions for the field

J. Mater. Chem. B, 2026, 14,2815-2831
DOI: 10.1039/D5TB02341F, Perspective

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Matthew D. Wood, Nisha Iyer, Stephanie M. Willerth
The field of neural biomaterials has evolved considerably over the past 25 years as new techniques and technologies have been developed for treating the diseases and disorders of both the spinal cord and peripheral nervous system.
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Bioengineered Escherichia coli Nissle 1917 with hematoporphyrin monomethyl ether for targeted sonodynamic therapy and immune activation in ovarian cancer

J. Mater. Chem. B, 2026, 14,2977-2987
DOI: 10.1039/D5TB02928G, Paper

Yue Pei, Huan Yi, Lingsi Chen, Xiangqin Zheng, Bo Liu
This bioengineered probiotic platform HW@EcN presents a clinically translatable approach for improving SDT efficacy and immune activation, paving the way for innovative cancer therapies.
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Nanoplatform-mediated metabolic reprogramming to overcome resistance mechanisms in antitumor therapies

J. Mater. Chem. B, 2026, 14,2675-2696
DOI: 10.1039/D6TB00098C, Review Article

Xin-Xin Lu, Jiao-Jiao Yang, Fan Gao
This review highlights the recent advances in functional nanoplatforms designed to regulate metabolism at tumor sites and effectively sensitize tumors to various treatments.
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Advances in Fenton reaction-mediated ferroptosis for enhanced cancer therapy: mechanisms, amplification strategies, and synergistic approaches

J. Mater. Chem. B, 2026, 14,2774-2794
DOI: 10.1039/D5TB02738A, Review Article

Qinqin Huang, Chenyu Ma, Ping Wei, Qiyue Wang, Hao Ren, Xueming Li
Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has emerged as a promising strategy for cancer therapy.
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A multistage drug delivery system via 3D-printed personalized TPU scaffold and microfluidic microspheres for nurse-led outpatient treatment of endometrial cancer

J. Mater. Chem. B, 2026, 14,2930-2939
DOI: 10.1039/D5TB02599K, Paper

Yuxiang Qin, Jianhong Liu, Kaixin Wang, Xingyu Gui, Canyu Gao, Jingting Huang, Li Wang, Yan Wang, Ying Zheng, Changchun Zhou
Schematic diagram of the multi-level drug delivery system using 3D-printed personalized TPU scaffolds and microfluidic microspheres.
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Microfluidic fabrication of dexamethasone-loaded silk fibroin microspheres for targeted pulmonary drug delivery

J. Mater. Chem. B, 2026, 14,2857-2865
DOI: 10.1039/D5TB02398J, Paper

Tianyuan Zhang, Bingyu Cai, Fengyuan Zhang, Min Wang
Green microfluidic self-assembly produces inhalable silk fibroin microspheres with high drug loading and sustained release for targeted pulmonary anti-inflammatory therapy.
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Imidazolium-tethered red-emissive iridium AIEgen for sensitive detection of NAD(P)H in aqueous and cellular media

J. Mater. Chem. B, 2026, 14,2866-2876
DOI: 10.1039/D5TB02044A, Paper

Aryan Gautam, Ajay Gupta, Deepika Chauhan, Amit Kunwar, Pijus K. Sasmal
A cationic iridium AIEgen probe, incorporating an imidazolium group, was designed for highly sensitive and selective detection of NAD(P)H in both aqueous environments and the mitochondria of living cells.
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Application of the novel polysaccharide “colanic acid (CA)” in submucosal injection and wound repair for endoscopic submucosal dissection

J. Mater. Chem. B, 2026, 14,2877-2893
DOI: 10.1039/D5TB02438B, Paper

Mengyi Deng, Dan Luo, Zhengkui Zhou, Panxianzhi Ni, Ming Ming Luo, Xiaoshuang Yan, Jiahua Pu, Xiaobin Sun, Chao Zhong, Jing Shan
Endoscopic submucosal dissection (ESD) is a key minimally invasive treatment for early gastrointestinal tumors. The novel polysaccharide colanic acid (CA) aids ESD: it facilitates intraoperative submucosal injection and promotes post-operative wound repair.
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High-performance flexible dual strain-temperature sensor based on a sandwich-architecture hydrogel

J. Mater. Chem. B, 2026, 14,2918-2929
DOI: 10.1039/D5TB02541A, Paper

Du Ding, Fang Ren, Yameng Li, Xiaoning Liu, Jing Yao, Zhengzheng Guo, Zhenfeng Sun, Yanling Jin, Penggang Ren
Developing high-performance hydrogel sensors offering simultaneous skin compatibility, mechanical/thermal sensitivities and outstanding durability is essential for skin-mimicking applications. Images created with Blender (http://www.blender.org); the top two rightmost images were revised with Gemini Pro.
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Designing of porous scaffolds for tissue engineering and regenerative medicine

J. Mater. Chem. B, 2026, 14,2733-2773
DOI: 10.1039/D5TB02507A, Review Article

Rajashree Sahoo, A. Swaroop Sanket, Ananya Pattnaik, Swarnaprabha Pany, Sanghamitra Pradhan, Sanghamitra Pati, Håvard Jostein Haugen, Dario Puppi, Sangram Keshari Samal
Representing porous scaffold-based tissue engineering techniques and their applications in various parts of the human body.
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SERS active silk silver films as a platform for osteogenic biomarker detection

J. Mater. Chem. B, 2026, 14,2843-2856
DOI: 10.1039/D5TB02229K, Paper

Namrata Tiwari, Manleen Kaur, Ritu Das, Nitish Kumar, Neetu Singh
Schematic for biomarker detection secreted from cells grown on an ECM-mimicking silk silver film platform via SERS. Cell-secreted biomarkers diffuse onto the film and are detected via SERS signals generated in the presence of Ag nanoclusters.
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Folate receptor-α targeted delivery of berberine via folate-functionalized bovine serum albumin nanocarriers to enhance intracellular internalization and suppress 3D spheroid formation as a pioneering therapeutic modality for glioblastoma

J. Mater. Chem. B, 2026, 14,2894-2917
DOI: 10.1039/D5TB01715G, Paper

Sayantan Ghosh, Puja Das, Bismita Nayak
Folic acid-conjugated berberine-loaded BSA nanoparticles inhibit glioblastoma cell migration and trigger apoptosis via ROS generation and mitochondrial membrane potential loss, achieving targeted delivery through folate receptor mediated endocytosis.
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Extracellular vesicles for heart repair: origins, functions, bioengineering strategies, and therapeutic potential

J. Mater. Chem. B, 2026, 14,2697-2732
DOI: 10.1039/D5TB02080H, Review Article

Liufang Wu, Si Shen, Changning Qian, Nuanyang Wu, Xiaozhong Qiu, Honghao Hou
This review covers EVs' sources, traits, engineering strategies, and clinical applications in cardiac regeneration. It details bioengineering and repair mechanisms, showing significant therapeutic potential and future prospects.
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Discovering Naturally Occurring Antifreeze Peptides from Microbiome by Integrating Protein Language Models and Molecular Dynamics Simulation

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02758F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ibrahim A Imam, Trevor Morey, Yuexu Jiang, Duolin Wang, Dong Xu, Qing Shao
Antifreeze peptides (AFPs) inhibit ice crystal growth and recrystallization, and are promising components of cryoprotective formulations for cell, tissue, and food preservation, as well as anti-icing surface coatings. However, the...
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Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D6TB00267F, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

James H. Westbay, Daniel P. Bigley, Sushma Sappa, Anfisa Ayalon, Hamzah Aweidah, Lauren D. Dignam, Joseph N. Martel, William A. Beltran, José-Alain Sahel, Leah C. Byrne, Morgan V. DiLeo
There is a need to develop safer, more efficient, and targeted strategies for the delivery of retinal gene therapies.
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Antibacterial peptide microspheres and recombinant human type XVII collagen (rhCXVII) modified protein hydrogels for synergistically combating dental caries

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D6TB00100A, Paper

Ting Zheng, Qiaoyue Ren, Hang Chen, Yujia Xie, Xinlei Zhao, Ding Xiong, Yang Yao, Zhenming Wang, Yu Shi
Dental caries is a classic biofilm-induced disease characterized by an imbalance between the demineralization and remineralization of the hard tissues of teeth. Effective anticaries materials and techniques should possess both...
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Polysaccharide-based hydrogels for alveolar socket healing: biological functions and material design strategies

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D6TB00167J, Review Article

Yuxuan Guo, Hongtao Hu, Bo Yang, Liao Wang, Chongyun Bao
This paper details key events in the healing of extraction sockets, systematically reviews polysaccharide hydrogel systems applied to extraction sockets, and links their composition, structure, and formulation to the healing process.
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A magnetic multi-enzyme nanoplatform for high-purity collagen preparation through efficient contaminant protein elimination

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02376A, Paper

Zibing Zeng, Wenhao Guo, Nannan Wei, Xiangdong Cai, Jianxi Xiao
An efficient, reusable, and readily separable magnetic multi-enzyme nanoplatform (MagMEN) was engineered for the highly effective preparation of high-purity collagen through systematic contaminant protein removal.
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Green synthesis of a bacitracin@Ag-CeO 2 nanocomposite@hydrogel for dual antibiofilm and anti-inflammatory therapy against MRSA wound infections

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02286J, Paper

Raman Krishnamoorthi, Chien-Yu Hsiao, Yi-Ping Chou, Pambayan U Mahalingam, Jia-You Fang, Abdullah Alshetaili
Skin wound healing is a complex and tightly regulated process. Bacterial biofilm infection in wounds further complicates and delays skin recovery. Here, green synthesis was used to develop a novel...
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Porous Organosilica Nanoparticles Enable UV Blocking and Two-Photon Fluorescence Imaging

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02771C, Paper

Aleksandra Pavlović, Irena Miler, Marta Bukumira, Marko Milojević, Branislav Jović, Mihailo D Rabasovic, Nikola Ž Knežević
Porous organosilica nanoparticles (PONs) are promising hybrid materials for a wide range of advanced applications, particularly in biomedical imaging, therapeutic delivery systems, and UV protection, due to their tunable organic-inorganic...
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Microenvironment-Responsive Hydrogel with Photothermal, Antioxidant, and Neuroregenerative Functions for Diabetic Chronic Infectious Wound Healing

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02313K, Paper

Zan Chen, Ye Wu, Heng Gong, Yunfeng Tang, Dong Wang, Zhen Wang, Ye Wang, Guanglin Wang, Wei Lin, Renliang Zhao, Cheng Zheng, Xiangtian Deng
Diabetic chronic infectious wounds (DCIW) remain a clinical challenge due to impaired vascularization, persistent infection, and excessive oxidative stress. Here, we report a multifunctional microenvironment-responsive hydrogel constructed via dynamic boronate...
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Design of a Cholic Acid-based Triarmed Star Polymer Network for Targeted and Sustained Drug Delivery for Melanoma Treatment

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D6TB00166A, Paper

Souvik Chowdhury, Swapan Maity, Alok Kumar, Rohan Sahu, Jairam Meena, Ashish Agarwal, Hitesh Chandpa, Pralay Maiti
The growing challenge of therapy resistance in cancer remains a major obstacle in clinical oncology, limiting the long term success of conventional chemotherapeutics such as doxorubicin (Dox). Although Dox exhibits...
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MXene-Loaded Hydrogels for Tissue Regeneration: A Review of Recent Advances and Future Perspectives

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02696B, Review Article

Satheesh Selvaraj, S. Rajasekaran, Ankush Chauhan, Majid S. Jabir, Suresh Ghotekar
MXene-loaded hydrogels represent a potential category of multifunctional biomaterials that combine the remarkable physicochemical features of MXenes with the adjustable structure and biocompatibility of hydrogels for tissue regeneration purposes. Due...
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Enzyme-Responsive Targeted Nanomedicines: A Novel Strategy for Cancer Therapy

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D6TB00076B, Review Article

Mingtang Zeng, Zhongzhen Yang, Liuxuan Yang, Xueyan Wang, Yao Wang, Tao Chen, Xi Yin, Fengbo Wu
Enzyme-responsive targeted nanomedicines have emerged as a promising approach for precision cancer therapy, capitalizing on the unique biochemical features of the tumor microenvironment (TME) to achieve localized and controlled drug...
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Toward continuous and non-invasive monitoring: a scoping review of in vitro blood glucose devices from electrochemistry to optics and micro-system integration

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02338F, Review Article

Wanmeng Wang, Chongyu Liu, Peiwen Lin, Suo Li, Yongchao Yao, Zhuqing Wang, Wenchuang (Walter) Hu
This review traces blood-glucose monitoring from invasive to non-invasive systems, summarizing sensor evolution, core MIBGM architectures, non-invasive modalities, key devices, and challenges in reliable, patient-friendly monitoring.
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Strategies to improve intracellular delivery of arginine-rich cell-penetrating peptides

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02935J, Review Article

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Rachel Anjous, P. Kavyashree, Abhishek Saha
This review discusses the ongoing strategies that are implemented to improve the cellular entry of Arg-rich cell-penetrating peptides and their applications in drug delivery research. Potential challenges and future directions are also highlighted.
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An anthracene-based molecular rotor as a theranostic agent for viscosity sensing and imaging-guided photodynamic therapy

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02822A, Paper

Ailada Jantasin, Supranee Watpathomsub, Thitima Pewklang, Tunyawat Khrootkaew, Sirimongkon Aryamueang, Bongkot Ouengwanarat, Kantapat Chansaenpak, Mongkol Sukwattanasinitt, Anyanee Kamkaew
Anthracene-extended cyanine molecular rotors enable viscosity-sensitive fluorescence imaging and heavy-atom-free NIR photodynamic therapy. π-Extension promotes intersystem crossing and singlet oxygen generation for bright imaging-guided treatment.
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Control of site-specific deprotonation through mechanochemical interconversion of two ionic cocrystal forms of resveratrol

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02000J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Bowyn D Ziebarth, Liulei Ma, Gary C. George III, Kristin M Hutchins
In drug development, multicomponent pharmaceutical materials have become useful tools for improving the properties and efficacy of a drug. In addition to the active drug, inclusion of a second component...
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A tumor-targeting gambogic acid-loaded nanovaccine reprograms the tumor microenvironment for enhanced cancer immunotherapy

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02673C, Paper

Ning Wang, Xingzhi Han, Xueying Bai, Zixin Liang, Xinyi Xu, Liuqi Sang, Li Li, Jing Hu, Qun Zhang, Xiaoping Qian
Nanovaccines for co-delivering antigens and adjuvants have demonstrated certain efficacy in cancer immunotherapy.
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Bactericidal activity of the layered cupric hydroxyfluoride Cu(OH)F against pathogenic Escherichia coli strain

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02621K, Paper

Batiste Clavier, Miriama Šimunková, Fabien BOUCHER, V. Brezova, Christine Roques, Gwenaël Corbel
Micrometre-sized particles of layered cupric hydroxy-fluoride Cu(OH)F were prepared through hydrothermal route from CuO powder and diluted aqueous hydrofluoric acid. Thermogravimetric (TG) and Mass Spectrometric (MS) evolved gas analyses showed...
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Advances in patterned interface design and bonding performance of 3D-printed dental zirconia ceramics: a review

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02775F, Review Article

Wenshu Zhao, Yichen Li, Chong Wei, Shibao Li, Xiang Sun, Chun Li
This review systematically explores 3D-printed surface patterning of zirconia ceramics to overcome interfacial bonding limits, highlighting process-structure-performance relationships and future challenges.
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Incorporation of NU-1000 into Cellulose Acetate Membranes with Preserved Indoxyl Sulfate Adsorption

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D6TB00006A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Rita F. Pires, Beatriz S. Nunes, Flávia S. C. Rodrigues, Anup Paul, Ana Charas, Anirban Karmakar, Mónica Faria
Zirconium-based metal–organic framework (MOF) NU-1000 was successfully synthesized and exhibited the expected structural and chemical properties, confirming its suitability as an adsorbent for protein-bound uremic toxins (PBUTs). In batch experiments,...
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Stimuli-Responsive Phenothiazine–Tetraphenylethylene Hybrid Luminogens: Mechano- and Piezochromic Properties with Anticancer Applications

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02340H, Paper

Rajneesh Misra, Ramakant Gavale, Faizal Khan, Siddharth Singh, Srija Mukherjee, Hem Chandra Jha, Guanjun Xiao, Bo Zou, Jiayi Yang
Mechanochromic and piezochromic luminogens represents a class of stimuli responsive materials, in which the emission colour or intensity changes reversibly in response to external mechanical stimuli such as grinding, pressing...
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Facile Electroless Displacement Plating of Mesoporous Gold Films as Robust and Reproducible SERS Substrates for Biosensing

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02458G, Paper

Daiki Masaoka, Kaito Kono, Mostafa Kamal Masud, Carlos Salomon, Md. Shahriar A. Hossain, Asep Sugih Nugraha, Joel Henzie, Yusuke Asakura, Emtiaz Ahmed, Mandy H. M. Leung, Yusuke Yamauchi
Mesoporous gold and silver films on copper (Mp-Au/Cu and Mp-Ag/Cu) are fabricated via a micelle-templated electroless displacement deposition. This one-step, substrate-flexible method generates uniform, highly porous metallic films with excellent...
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MicroRNA Nanocapsules for Modulating Macrophage Polarization to Promote Bone Repair

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02318A, Paper

Xueping Li, Ming Zhang, Qi Zhan, Sai Gao, Yahan Zhang, Xiaolei Sun, Lixia Long, Xin Hou, Chaoyong Liu, Jin Zhao, Xubo Yuan
Macrophages, highly versatile immune cells, play essential roles in various pathological conditions. The ability to modulate macrophage phenotypes presents a promising therapeutic strategy. Rapidly transitioning macrophages from the pro-inflammatory M1...
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Toward reproducible SERS biosensing: analysing instability origins and mitigation approaches from sample preparation to detection

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02751A, Review Article

Aochi Liu, Chenyang Gao, Jing Xue, Yujiao Xie, Xinyu Miao, Tianxiang Chen, Aiguo Wu, Jie Lin
Key SERS biosensing instability sources, including analyte aggregation and crystallization, substrate structural and hot-spot non-uniformity, and detection artifacts like noise and defocus distortion, are outlined.
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Controlled release of bone morphogenetic protein-2 improves motor function after traumatic brain injury in a rat model

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02643A, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Jakob M. Townsend, Jasmine Z. Deng, Scott Barbay, Brian T. Andrews, David J. Guggenmos, Randolph J. Nudo, Michael S. Detamore
Illustration of the traumatic brain injury rat model and implantation of the thiolated devitalized tendon (TDVT) hydrogel delivering PLGA microspheres releasing bone morphogenetic protein (BMP)-2.
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Nickel tungstate nanoparticles synthesized via a surfactant-assisted method: an efficient platform for neurotransmitter detection

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02003D, Paper

Werayut Srituravanich, Balasubramanian Akila, Tse-Wei Chen, Shen-Ming Chen, Umesh Narasimha Murthy, Elayappan Tamilalagan, Bih-Show Lou, Sakthivel Kogularasu, Guo-Ping Chang-Chien
Accurate detection of dopamine (DPM) is critical due to its essential role in neurological function and its occurrence across diverse biological and food matrices.
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Biodegradable polyurethane nerve conduits functionalized with NDP-MSH-loaded self-assembling peptide hydrogels for peripheral nerve regeneration

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02626A, Paper

Junhong Li, Jinghan Wang, Xirui Long, Jingjing Lin, Mi Su, Chang Ding, Rongxu Lin, Feng Luo, Jiehua Li, Yanhui Liu, Yanchao Wang, Hong Tan
A biodegradable BWPU nerve conduit with a pH-responsive self-assembling peptide depot releases NDP-MSH to reduce ROS/apoptosis and promote M2 macrophages, enabling sciatic nerve repair comparable to autografts.
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Proteomics in Tissue Regeneration: Insights into Protein Alterations and Post-Translational Modifications during Healing

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02812D, Review Article

Sarad Pawar Naik Bukke, Chandrashekar Thalluri, Jharna Medhi, Mallikarjun Vasam, Neha Gupta, Piyali Dey, Milon S Dennison, Muhamad Mustafa Mundu
Tissue regeneration is a complex, multi-phase process orchestrated by dynamic changes in protein expression and post-translational modifications (PTMs). Proteomics has emerged as a transformative tool for decoding these molecular events,...
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Biofilm-Penetrating Nanozyme Robot for Drug-Free Inactivation of Drug-Resistant Bacteria

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02853A, Paper

Mansi Gaware, Saptami Goswami, Swati Sahai, Govind Chate, Tonmoy Banerjee, Swati Biswas, Ravindra D Wavhale, Shashwat Subrata Banerjee
The emergence of antibiotic-resistant bacterial infections mainly due to the proliferation of bacterial biofilms, pose a critical clinical challenge. The low efficacy of currently used antibacterial agents, caused due to...
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Supramolecular adenosine-based skin delivery system for hair regulation and restoration

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02625C, Paper

Yixuan Tang, Weihao Gao, Hongwei Fu, Tianqi Liu, Zhenyuan Wang, Lujie Yu, Xiangli Liu, Mi Wang, Jichuan Zhang, Jiaheng Zhang
We report TA–Ado, an adenosine-tartaric acid cocrystal. It enhances the transdermal delivery of adenosine and exhibits synergistic bioactivities. Clinical data confirm its safety and efficacy for scalp care.
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Polarity-Switchable Photoelectrochemical Biosensors: Applied Materials, Advances, and Mechanisms

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D6TB00223D, Review Article

Kheibar Dashtian, Forough Zahedpour, Amin Foroozandeh, Majid Abdouss, Shaaker Hajati
Photoelectrochemical (PEC) biosensors are gaining significant attention due to their high sensitivity, low background interference, and compatibility with various nanomaterials and biorecognition elements. Traditional PEC approaches, such as signal-off and...
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Scalable One-Step Synthesis of Gelatin-Dithiolane for Neural Tissue Engineering

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02915E, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Muhammad Waqas Ishaq, Asma Talib Qureshi, Saad Asim, Akanksha Subbarao, Muhammad Rizwan
Protein-based hydrogels crosslinked using dithiolanes provide a promising viscoelastic matrix for soft tissue engineering and regenerative medicine including neural niche due to their inherent biocompatibility, bioactivity, and adaptable extracellular matrix...
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Antimicrobial Cotton Fabrics Modified with a Cationic Perylene Diimide Derivative for Durable and Superior Sterilization

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02871J, Paper

Jia Yin, Yuanyuan Zhu, Meiqi Li, Yuxin Ren, Yuze Wang, Wenhua Jia, Jiaying Miao, Ling Li, Yanli Tang
High biocidal efficacy, excellent durability and great biocompatibility are essential for the practical utility of antimicrobial fabrics in complex environments such as hospitals and wild-field. Herein, a novel perylene diimide...
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NIR-activated dual-mode oxygen-generating and -delivering nanoplatform for enhanced photodynamic therapy of cervical cancer

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02652K, Paper

Jiaxing Li, Chenyang Chu, Lijun Zhu, Zhong Du, Yaqi Cui, Jiabao Xiong, Chi Zhang, Yuxiang Gao, Biao Dong, Nuernisha Alifu
NIR-activated IFHFC nanoparticles enable NIR-I/NIR-II imaging and dual oxygenation (CAT-catalyzed O₂ generation and PFH O₂ release), relieving hypoxia and boosting ROS for enhanced PDT.
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Combined experimental and DFT studies of amino acid adsorption on biomimetic apatite: application to serine

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02180D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Youness Hajji, Christophe Drouet, Stéphanie Sarda, Corinne Lacaze-Dufaure
Biomimetic apatite nanocrystals, as synthetic analogs of bone apatite, offer a more realistic bone mineral model than regular stoichiometric hydroxyapatite (HAP) for studying biomolecule–bone mineral interactions.
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Poly(γ-glutamic acid)-thickened PLLA microspheres with enhanced biocompatibility and efficacy in aged mice

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02761F, Paper

Dan-Qi Ren, Hui-Zhen Peng, Yue Zhang, Yue Yue, Yu Chen, Yun-Li Zhao, Ming-Long Yuan, Xiao-Dong Luo
This study presents γ-PGA thickened PLLA microspheres for skin rejuvenation. The formulation ensures stable deposition and enhances biocompatibility, stimulating sustainable collagen regeneration and long-term safety in aged skin.
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A Molecular Engineering Platform for Enhanced Stokes Shift NIR-II Fluorophores Enabling High-Fidelity 1400 nm In Vivo Imaging

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02789F, Paper

Tong XiangLi, Ya ni Shang, Yongjie Chen, Qinghua Wu, Shenwei Chen, Hongbing Ji, Jin Li
Fluorescence imaging in the second near-infrared window (NIR-II, 900-1700 nm) offers superior spatial resolution and penetration depth for in vivo visualization due to reduced tissue scattering and autofluorescence. However, the...
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Hierarchical MOF-on-MOF Structured Dual-Functional Nanozyme for Enhanced Catalysis and Dual-Channel Detection of α-Glucosidase

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02691A, Paper

Qingjie Fu, Haosen Fan, Shuo Tian, Mengke Wang, Shun Wang, Kelong Fan
Metal-organic framework (MOF)-on-MOF hybrids have garnered significant interest due to their ability to integrate multiple catalytic functions within a single nanostructure. The synergistic interactions between MOF components often yield emergent...
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Supramolecular Peptide Hydrogel-Mediated Synergistic Antibiotic-Photothermal Therapy for Potent Antibacterial Applications

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02333E, Paper

Chengfan Wu, Wenjie Liao, Hongquan Wang, Yujia Zhang, Yiqing Chen, Yue Li, Qiu Meng, Yunfeng Yan, Qing Zhu
Bacterial infection usually exacerbates inflammation and is one of the important factors impeding wound healing. At present, dressings for treating wound infections often include antibiotics, silver ions, fibers, etc., but...
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Multifunctional stealth chitosan nanogels with improved relaxivity and photoacoustic contrast for dual MRI–MSOT imaging

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02722E, Paper

Camille Gosée, Juliette Moreau, Cyril Cadiou, Christelle Kowandy, Maité Callewaert, Céline Henoumont, Lionel Larbanoix, Alexandre Berquand, Sorina N. Voicu, Christophe Portefaix, Sophie Laurent, Françoise Chuburu
Stealth nanogels based on chitosan grafted with ZW800-1 and PEG2000, incorporating Gd chelates, enable bimodal MRI/photoacoustic imaging with enhanced contrast properties in both modalities.
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Advances in spherical nanoparticle-labeled lateral flow immunoassays in the field of clinical detection

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02490K, Review Article

Yongwei Zhang, Hongyan He, Jingwei Wang, Zuomin Wu, Jingyuan Dong, Jin Wang
Schematic illustration of spherical nanolabel-assisted LFIA for clinical sample detection.
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Self-assembled hydrogels promote wound healing

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02548F, Review Article

Da Lin, Yanqiang Huang, Yuna Qian, Jianliang Shen, Hongyu Wei
This review integrates structural classification with therapeutic functions of self-assembled hydrogels, offering a perspective that advances beyond existing surveys and underscores their potential as innovative strategies for effective wound repair.
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Phenylboronic acid functionalized resveratrol-based nanomedicines with enhanced targeting for synergistic chemo-photothermal breast cancer therapy

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02941D, Paper

Qirui Bi, Danni Liu, Yunfei Tan, Pengyu Hu, QiuLan Tong, Lei Ma, Jianming Jiang, Xudong Li, Zeng Yi
The combination of photothermal therapy (PTT) and chemotherapy (CT) offers a promising approach for enhanced cancer treatment.
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Retraction: Surface modification engineering of two-dimensional titanium carbide for efficient synergistic multitherapy of breast cancer

J. Mater. Chem. B, 2026, 14,2663-2663
DOI: 10.1039/D6TB90024K, Retraction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lei Bai, Wenhui Yi, Taiyang Sun, Yilong Tian, Ping Zhang, Jinhai Si, Xun Hou, Jin Hou
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Stable ultrabright nanoprobes for two-photon excitation microscopy based on octupolar merocyanine-loaded nanovesicles

J. Mater. Chem. B, 2026, 14,2594-2611
DOI: 10.1039/D5TB02465J, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Sara Garrido-Rodríguez, Yevgen M. Poronik, Andrea Delledonne, Silvia Pescina, Guillem Vargas-Nadal, Judit Morla-Folch, Ottavia Racchi, Francesco Di Maiolo, Nora Ventosa, Cristina Sissa, Daniel T. Gryko, Mariana Köber
Through molecular design and systematic screening, nanoprobes with strong two-photon brightness and stability were developed and validated in ex vivo porcine tissue imaging.
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Retraction: Triple-responsive inorganic–organic hybrid microcapsules as a biocompatible smart platform for the delivery of small molecules

J. Mater. Chem. B, 2026, 14,2662-2662
DOI: 10.1039/D6TB90023B, Retraction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Alexander S. Timin, Albert R. Muslimov, Kirill V. Lepik, Natalia N. Saprykina, Vladislav S. Sergeev, Boris V. Afanasyev, Alexander D. Vilesov, Gleb B. Sukhorukov
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Supramolecular engineering of an azelaic acid–nicotinamide cocrystal for dual anti-inflammatory and brightening efficacy

J. Mater. Chem. B, 2026, 14,2568-2577
DOI: 10.1039/D5TB02498F, Paper

Zhenyuan Wang, Biao Wang, Jiawen Chen, Mi Wang, Jiaheng Zhang
We developed a novel cocrystal, [AzA][Nic], which significantly enhances the solubility and bioactivity of azelaic acid. Both in vitro and in vivo experiments confirm its superior anti-inflammatory and skin-brightening effects.
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A photothermally enhanced oxygen-releasing and antibacterial hydrogel accelerating diabetic wound healing via energy metabolism regulation

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D6TB00018E, Paper

Maojiao Li, Huiyu Zheng, Yan Chen, Bo Huang, Guiting Liu
ORN@Se-HAMA hydrogel enables NIR-triggered oxygen release via PDA layer on CaO₂/CAT core. Combined Se NPs and photothermal effect achieve dual antibacterial action and metabolic reprogramming for accelerated diabetic wound healing.
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Numerical estimation of drug loading contents in amphiphilic nanogels

J. Mater. Chem. B, 2026, 14,2578-2593
DOI: 10.1039/D5TB02138C, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ante Markovina, Clara López-Iglesias, Ruiguang Cui, Daniel Klinger
A quantitative framework links theoretical Flory–Huggins interaction parameters to experimental drug loading contents in amphiphilic nanogels. Resulting strong monotonic correlations support the rational design of nanogel carriers for specific drugs.
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Co-delivery of synaptogenic and angiogenic nanoparticles in MAP scaffolds enhances post-stroke synapse formation

J. Mater. Chem. B, 2026, 14,2461-2477
DOI: 10.1039/D5TB02179K, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Nhi V. Phan, Jeremy L. Thomas, Aiden Pasinsky, Zoe Meadows, Ting Ting Li, Augustus Adams, Yike Zhu, Anna Edgcomb, Yi Shi, Sihan Lyu, Timothy W. Dunn, Tatiana Segura
TSP-1 nanoparticles and VEGF nanoparticles loaded into granular hydrogel MAP scaffolds demonstrate increased synapse formation after ischemic stroke.
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The chemical design of antimicrobial ionic liquids guided by machine learning: a review on balancing efficacy and toxicity

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02581H, Review Article

Zheng Liu, Qiuyu Chen, Congfei Yao, Yimin Wang, Siqi Zhu, Jinyu Guan, Yuqing Miao
An integrated framework combines mechanistic insights, structure–activity–toxicity relationships, and machine-learning optimization to design and screen antimicrobial ionic liquids with balanced efficacy and reduced toxicity.
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Photocleavable luminescent conjugates of 2-(2-aryl-5-(piperidin-1-yl)-2H-1,2,3-triazol-4-yl)thiazoles and aminoacids, diagnostics and drugs

J. Mater. Chem. B, 2026, 14,2530-2542
DOI: 10.1039/D5TB02183A, Paper

Timur O. Fomin, Vitalii A. Krasilnikov, Vadim A. Shevyrin, Artem S. Minin, Enrico Benassi, Nataliya P. Belskaya
We developed highly fluorescent photocages based on a 2-aryl-1,2,3-thiazol-4-yl-1,2,3-thiazole core. Extensive experimental and theoretical studies demonstrated their excellent properties compared to published light-based masking systems.
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An in situ-forming injectable silk hydrogel with a cocktail of chemotherapeutic drugs simultaneously targeting cancer cells and cancer stem cells

J. Mater. Chem. B, 2026, 14,2612-2629
DOI: 10.1039/D5TB02316E, Paper

Jeyashree Kumarasekar, Abhiram Kumar, Jayakumar Rajendran, Kumar Pranav Narayan, Jyotsnendu Giri
Schematic illustration of an in situ injectable silk hydrogel enabling sustained co-delivery of doxorubicin and salinomycin for simultaneous targeting of breast cancer cells and cancer stem cells, leading to enhanced anticancer efficacy.
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A theranostic endoperoxide agent with targeted singlet oxygen release and concomitant fluorescence signals

J. Mater. Chem. B, 2026, 14,2438-2449
DOI: 10.1039/D5TB02315G, Communication

Shoucai Yan, Yu Si, Xiao Qian, Rensong Sun, Wanwan Wang, Ziang Liu, Yang Wang, Lei Wang, Engin U. Akkaya
A bimodular endoperoxide derivative enables spatiotemporally controlled activation of dual functions within the tumor microenvironment—therapeutic singlet oxygen generation and H₂O₂-responsive diagnostic signaling.
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Hydrogels for in vivo biomedical applications: recent advances and future perspectives

J. Mater. Chem. B, 2026, 14,2386-2406
DOI: 10.1039/D5TB02265G, Review Article

Chenyu Shen, Ying Wang, Xinzhou Xiao, Riyun Yang, Hangyu Chen, Peng Yuan, Yonghui Zhang, Guangming Lyu, Jaemyung Shin, Gang Chen, Zhangkang Li
This review presents an overview of hydrogel-based in vivo biomedical applications and discusses key material properties, performance requirements, and future directions for regenerative medicine and precision therapy.
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Single-chip multitarget detection by EGOFET-based aptasensors

J. Mater. Chem. B, 2026, 14,2543-2555
DOI: 10.1039/D5TB02347E, Paper

Elena Yu. Poimanova, Elena A. Kretova, Anna K. Keshek, Askold A. Trul, Elena G. Zavyalova, Elena V. Agina
EGOFET-based aptasensor with a single recognition element for multitarget detection on a single chip.
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AIE-active anthraquinone-derived sonosensitizers with enhanced reactive oxygen species generation for ultrasonic biofilm eradication

J. Mater. Chem. B, 2026, 14,2556-2567
DOI: 10.1039/D5TB02280K, Paper

Dongmei Deng, Junjie Chen, Haijian Meng, Yichao Wen, Yonggang Min
AIE-active anthraquinone-based sonosensitizers eradicate bacterial biofilms via aggregation-enhanced ROS generation under ultrasound.
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Poly(D,L-lactide)-grafted Cu-doped bioactive glass microspheres as core–shell building blocks for biomaterials: from grafting to early-stage in vitro behaviour

J. Mater. Chem. B, 2026, 14,2644-2661
DOI: 10.1039/D5TB02273H, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Gabriele Vecchio, Valentine Poissonnet, Audrey Béthry, Marie-Pierre Castanié-Cornet, Agnès Dupret-Bories, Christèle Combes, Fabien Brouillet, Sylvain Le Grill, David Bertrand, Vincent Darcos, Jérémy Soulié
PDLLA grafting-dependent Cu-release and in vitro behaviour.
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A biomimetic phage-inspired supramolecular system based on glucose-conjugated pillar[5]arene with ciprofloxacin hydrochloride

J. Mater. Chem. B, 2026, 14,2450-2460
DOI: 10.1039/D5TB02829A, Paper

Yulia I. Aleksandrova, Dmitriy N. Shurpik, Arina V. Pergat, Alan A. Akhmedov, Olga A. Mostovaya, Mikhail S. Bukharov, Yulia O. Bukarinova, Evgenia V. Subakaeva, Evgeniya A. Sokolova, Ivan I. Stoikov
Glucose-modified pillar[5]arene self-assembled into a biocompatible phage-inspired carrier with ciprofloxacin to double the inhibitory effect on a K. pneumoniae strain with increased resistance.
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Laser-induced graphene on the surface of carbon-coated 3D-printed microneedle arrays for minimally invasive electrochemical detection of olanzapine

J. Mater. Chem. B, 2026, 14,2630-2643
DOI: 10.1039/D5TB02162F, Paper

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sachin Kadian, Siba Sundar Sahoo, Fahad Munshe, Shubhangi Shukla, Roger J. Narayan
We have developed a straightforward and scalable fabrication strategy to create laser-induced graphene on the tips of a carbon-coated 3D-printed microneedle array-based wearable electrochemical sensor to detect OZP in interstitial fluid.
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Amplifying the “in situ vaccination” of BET inhibition via autophagy blockade: mechanisms and local delivery in OSCC

J. Mater. Chem. B, 2026, 14,2518-2529
DOI: 10.1039/D5TB02525G, Paper

Lingling Wei, Haoyu Jin, Zhongke Ji, Haoyang Tian, Jiayang Han, Yanyan Liu, Wanjia Li, Di Liu, Hui Song
Blocking autophagy with chloroquine, delivered via a self-assembled nanoparticle-loaded microneedle system, amplifies the JQ1-induced ICD and antitumor immunity in OSCC.
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Advances in therapeutic strategies for atherosclerosis: from pharmacologics to stents and stent coatings

J. Mater. Chem. B, 2026, 14,2407-2437
DOI: 10.1039/D5TB02293B, Review Article

Anitha T. A., Anupama Vallazhath, Vijayakumar Maniyal, Deepthy Menon
A spectrum of anti-atherosclerotic approaches aimed at restoring vasculature, from pharmacological agents to recent advances in stent coatings.
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High selectivity and significant cytotoxicity of rare earth naphthalene dicarboxylate complexes on non-small cell lung cancer cells

J. Mater. Chem. B, 2026, 14,2506-2517
DOI: 10.1039/D5TB01473E, Paper

Hao Wang, Jiaxin Wang, Rui Wang, Liang Zhou
The mechanism and antitumor effect of Er(TTA)₃NI-Phen induced apoptosis in H1299 cells.
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A macrocyclic gadolinium contrast agent bearing an assembly-dissociable feature with albumin for enhanced magnetic resonance imaging and in vivo profiles

J. Mater. Chem. B, 2026, 14,2495-2505
DOI: 10.1039/D5TB02169C, Paper

Yimin Gong, Yichen Yao, Zhuoying Ruan, Nan Mei, Dan Luo, Xiaofeng Liu, Yongtai Yang, Yu Jia, Yannan Yang, Bo Yin, Yaming Zhou, Yun Ling
A novel macrocyclic GBCA, namely Gd-IN-DO3A, was designed, which exhibits an assembly-dissociable feature with HSA at Sudlow site II via moderate non-covalent interactions. The HSA-adducts ensure enhanced T₁-weighted MRI and favorable in vivo profiles.
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A stepwise funnel selection approach identifying natural polymer-derived hydrogels for long-term islet delivery, restoring normoglycemia in type-1 diabetes

J. Mater. Chem. B, 2026, 14,2478-2494
DOI: 10.1039/D5TB02371H, Paper

Snehasish Mandal, Devyani Yenurkar, Sumit Manna, Rajdeep Bhattacharjee, Malay Nayak, Lipi Pradhan, Sudip Mukherjee
Pectin hydrogel capsules were developed for implanting islets to reverse hyperglycemia.
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Construction of Soluble Sufentanil Microneedles and Their Analgesic Effects in a Mouse Model of Cancer Pain

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02821C, Paper

Ayang Zhao, Yueyue Gao, Ao Zhang, Yuting Rong, Guibo Fan, Rui Xin, Sixun Chen, Liangcan He, Sihua Qi
Zhao contributed equally to this work. Yueyue Gao designed and optimized the microneedle fabrication method, characterized the microneedles' morphology and mechanical properties, performed data analysis and charting, established an animal...
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Immobilization of iridium nanoparticles on ITO substrate for selective transformation of glycerol to 1, 3-dihydroxyacetone and process tracking

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D6TB00058D, Paper

Lin Zhou, Zhanghong Guo, Haining Cui, Jin-Xin Ma, Chan Wang, Qijun Song
Glycerol (Gly) is a major by-product of biodiesel production, its conversion to high-value-added chemicals under mild conditions holds significant economic benefits. This study demonstrated that the efficient and selective conversion...
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The BSA mediating the proton coupled electron transfer to unlock the photo-generation of hydroxyl in cancer cells

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02650D, Paper

Guiyan Xu, Yingyong Ni, Xiao-Jiao Zhu, Xuan Zhao, Ting Wang, Shengyu Shi, Jianhua Yu, Qiong Zhang, Xingxing Chen, Hongping Zhou
The unique attributes of proteins-including their confined nanoscale cavities, abundant redox-active amino acid residues, and excellent biocompatibility-offer significant advantages for constructing protein-based enzymatic systems. However, their potential remains underexplored in...
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Smart natural polymer-based hydrogels for chronic wound management: advances in real-time monitoring and stimuli-responsive therapy

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02894A, Review Article

Yu-Qi Liu, Jun-Hang Luo, Zi-Jie Xu, Rui-Han Wang, Ming Yan, Zhe-Feng Kang, Zhi-Guo Wang, Bi-Bo Ren, Jia-Zhuang Xu, Zhong-Ming Li
Smart natural polymer-based hydrogels integrate real-time wound monitoring with stimuli-responsive therapy, enabling adaptive regulation of the wound microenvironment for intelligent and personalized chronic wound care.
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Intramolecular π-π Stacking-Regulated ROS Amplification in Water-Soluble GalNAc-Functionalized Tetraphenylethylene Photosensitizers for Hepatocellular Carcinoma

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02740C, Paper

Yin-Ju Li, Han-Che Hung, Yu-Sheng Tsai, CHAO-TSEN CHEN
Herein, a modular geminal-tetraphenylethylene (gem-TPE) photosensitizer platform is reported, integrating asialoglycoprotein receptor (ASGPR)-targeting GalNAc units with aryl-rich organelle-directing motifs to regulate intramolecular packing and photophysical behavior. A series of derivatives...
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Unveiling Aggregation-Induced Emission in Benzimidazole-Acrylonitriles for Fluorescent Live-Cell Imaging in HeLa Cells

J. Mater. Chem. B, 2026, Accepted Manuscript
DOI: 10.1039/D5TB02419F, Paper

Munugala Chandrakanth, Ayswarya Mukharjee, Rathinasamy K, Chinna Ayya Swamy Pothulapadu, Janardhan Banothu
Cellular imaging is a pivotal strategy for unraveling complex biological processes, disease mechanisms, and drug responses, wherein benzimidazole-acrylonitriles emerge as promising yet underexplored fluorogenic scaffolds for advanced imaging and therapeutic...
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Acellular cartilage matrix scaffolds for cartilage regeneration: current progress and future directions

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D6TB00068A, Review Article

Lijunpeng Jia, Junyi Cheng, Xing Wen, Ziwei Zhang, Hui Bao, Juanjie Fei, Zhipu Ding, Jingchi Li, Zhonghan Li
ACM scaffolds from decellularized cartilage offer low immunogenicity, high repair efficiency, and compatibility.
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Molybdenum nanoclusters as potent antioxidants for the treatment of osteoarthritis

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D5TB02482J, Paper

Hui Yang, Wei Liu, Renwei Wang, Bingbing Zhang, Wenge Wang, Jianlin Wu, Peng Jiang, Yandong Zhao, Xu Liang, Xiaotong Feng, Huawei Zhang
Schematic representation of MNs fabrication and their therapeutic function in the OA microenvironment.
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Treatment of diabetic wounds using dissolvable microneedle patches co-delivering levofloxacin and lidocaine

J. Mater. Chem. B, 2026, Advance Article
DOI: 10.1039/D6TB00040A, Paper

Arifur Rahman Nibir, Jamila Akther, Ferdous-Ul-Haque Joy, Tahmina Foyez, Md. Borhan Uddin, Shazid Md. Sharker
A dissolvable microneedle patch (MNP) system has been developed for localized co-delivery of levofloxacin and lidocaine. The dual-drug-loaded MNPs provide a minimally invasive, painless, and potentially therapeutic platform for diabetes wound care.
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Correction: Surface nanocrystallization enhances the biomedical performance of additively manufactured stainless steel

J. Mater. Chem. B, 2026, 14,2373-2373
DOI: 10.1039/D6TB90019D, Correction

Open Access

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sumit Ghosh, Sushma Indrakumar, Santanu Ghosh, Vasanth Gopal, Sagar Nilawar, Geetha Manivasagam, Jayanth S. Kesave, Satyam Suwas, Kaushik Chatterjee
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