RSC - Toxicol. Res. latest articles

In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes

Toxicol. Res., 2012, Accepted Manuscript
DOI: 10.1039/C2TX00010E, Paper

Andrew Kellett
1,10-Phenanthroline (phen, 5), 1,10-phenanthroline-5,6-dione (phendione, 6), [Cu(phendione)₃](ClO₄)2.4H₂O (12) and [Ag(phendione)₂]ClO₄ (13) are highly active, in vitro, against a range of normal and cancerous mammalian cells, fungal and insect cell lines,...
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A comparative cytotoxicity study of TiO2 Nanoparticles under Light and Dark Conditions at Low Exposure Concentrations

Toxicol. Res., 2012, Accepted Manuscript
DOI: 10.1039/C2TX00012A, Paper

Swayamprava Dalai, Sunandan Pakrashi, Suresh Kumar R.S., N Chandrasekaran, Amitava Mukherjee
The aim of the present study was to explore the difference in toxicity mechanism of TiO2 nanoparticles (NPs) at low concentrations ([less-than-or-equal] 1 [small micro]g/mL), in a freshwater bacterial isolate, Bacillus...
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Validation and quality control of replacement alternatives - current status and future challenges

Toxicol. Res., 2012, Accepted Manuscript
DOI: 10.1039/C2TX20011B, Review Article

Marcel Leist, Nina Hasiwa, Mardas Daneshian, Thomas Hartung
Alternatives to animal testing have been developed mainly in the fields of toxicology and vaccine testing. Typical examples are the evaluation of phototoxicity, eye irritation or skin corrosion/irritation of cosmetics...
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A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond

Toxicol. Res., 2012, Advance Article
DOI: 10.1039/C2TX20006F, Paper

Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao, Yen Wei
The cell uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide and nanodiamond were investigated and compared for the first time.
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Induction of plasma acetylcholinesterase activity and apoptosis in mice treated with the organophosphorus toxicant, tri-o-cresyl phosphate

Toxicol. Res., 2012, Advance Article
DOI: 10.1039/C2TX20009K, Paper

Wei Jiang, Ellen G. Duysen, Oksana Lockridge
Organophosphates induce acetylcholinesterase activity and apoptosis, suggesting that excess acetylcholinesterase in mouse plasma is a biomarker of apoptosis in tissues.
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Mitochondrial glutathione in toxicology and disease of the kidneys

Toxicol. Res., 2012, Accepted Manuscript
DOI: 10.1039/C2TX20021J, Review Article

Lawrence Harold Lash
The tripeptide glutathione (GSH), comprised of the amino acids L-cysteine, glycine, and L-glutamate, is found in all cells of aerobic organisms and plays numerous, critical roles as an antioxidant and...
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Mechanisms and Modifiers of Methylmercury-Induced Neurotoxicity

Toxicol. Res., 2012, Accepted Manuscript
DOI: 10.1039/C2TX20010D, Review Article

Stephanie Fretham, Samuel W Caito, Ebany J Martinez-Finley, Michael Aschner
The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided...
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Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure

Toxicol. Res., 2012, Accepted Manuscript
DOI: 10.1039/C2TX20008B, Paper

Sheng-Tao Yang, Tiancheng Wang, Erya Dong, Xin-xin Cheng, Kun Xiang, Jia-Hui Liu, Yuanfang Liu, Haifang Wang
Alumina nanoparticles (NPs) are among the most important nanomaterials and widely used in diverse areas. In this study, we evaluated the bioavailability and toxicity of alumina NPs in mice after...
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